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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:epinastine
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Accession:CHEBI:51032 term browser browse the term
Definition:A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.
Synonyms:exact_synonym: 9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine
 related_synonym: 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine;   Formula=C16H15N3;   InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18);   InChIKey=WHWZLSFABNNENI-UHFFFAOYSA-N;   SMILES=NC1=NCC2N1c1ccccc1Cc1ccccc21;   epinastina;   epinastinum
 xref: Beilstein:3593307;   CAS:80012-43-7;   DrugBank:DB00751;   Drug_Central:1027;   KEGG:D07900
 xref_mesh: MESH:C053090
 xref: Patent:GB2071095;   Patent:US4313931;   Reaxys:3593307;   Wikipedia:Epinastine


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epinastine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects transport ISO ABCB1A affects the transport of epinastine CTD PMID:15100174 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects transport ISO ABCB1B affects the transport of epinastine CTD PMID:15100174 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions EXP [epinastine binds to and results in decreased activity of HRH1 protein] which affects the susceptibility to Histamine; epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HRH1 mRNA] CTD PMID:12832840, PMID:19075512 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Ifng interferon gamma multiple interactions ISO epinastine inhibits the reaction [IL4 results in decreased expression of IFNG] CTD PMID:16534218 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il13 interleukin 13 decreases expression ISO epinastine results in decreased expression of IL13 mRNA; epinastine results in decreased expression of IL13 protein CTD PMID:16534218 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 multiple interactions ISO
EXP
epinastine inhibits the reaction [IL4 results in decreased expression of IFNG]
epinastine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 mRNA]
CTD PMID:16534218, PMID:19075512 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases expression ISO epinastine results in decreased expression of IL5 mRNA; epinastine results in decreased expression of IL5 protein CTD PMID:16534218 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 decreases expression ISO epinastine results in decreased expression of IL6 mRNA; epinastine results in decreased expression of IL6 protein CTD PMID:16534218 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO epinastine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Ngf nerve growth factor decreases expression ISO epinastine results in decreased expression of NGF protein CTD PMID:19937255 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO epinastine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        pharmacological role 18825
          antagonist 16213
            histamine antagonist 4607
              epinastine 11
                R-epinastine 0
                S-epinastine 0
                epinastine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      benzazepine 506
                                        epinastine 11
                                          R-epinastine 0
                                          S-epinastine 0
                                          epinastine hydrochloride 0
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