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Accession:CHEBI:5103 term browser browse the term
Definition:An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Synonyms:exact_synonym: ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
 related_synonym: Anexate;   Formula=C15H14FN3O3;   InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3;   InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N;   Lanexat;   SMILES=C1=NC(=C2N1C=3C(C(N(C2)C)=O)=CC(=CC3)F)C(OCC)=O;   flumazenilo;   flumazenilum
 xref: Beilstein:4763661 "Beilstein";   CAS:78755-81-4 "ChemIDplus";   DrugBank:DB01205;   Drug_Central:1195 "DrugCentral";   HMDB:HMDB0015336;   KEGG:C07825;   KEGG:D00697;   LINCS:LSM-4228
 xref_mesh: MESH:D005442
 xref: PMID:11881583 "Europe PMC";   PMID:23126253 "Europe PMC";   PMID:23431889 "Europe PMC";   PMID:24563235 "Europe PMC";   PMID:26324010 "Europe PMC";   PMID:26469689 "Europe PMC";   Reaxys:4763661 "Reaxys";   Wikipedia:Flumazenil

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flumazenil term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gabra1 gamma-aminobutyric acid type A receptor alpha1 subunit JBrowse link 10 27,310,718 27,371,802 RGD:6480464
G Gabra4 gamma-aminobutyric acid type A receptor alpha4 subunit JBrowse link 14 39,154,072 39,230,994 RGD:6480464
G Gabra6 gamma-aminobutyric acid type A receptor alpha 6 subunit JBrowse link 10 27,847,447 27,862,896 RGD:6480464
G Gabrb1 gamma-aminobutyric acid type A receptor beta 1 subunit JBrowse link 14 38,631,192 39,112,598 RGD:6480464
G Gabrb3 gamma-aminobutyric acid type A receptor beta 3 subunit JBrowse link 1 113,034,251 113,265,364 RGD:6480464
G Gabrg2 gamma-aminobutyric acid type A receptor gamma 2 subunit JBrowse link 10 27,090,913 27,179,786 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:6480464

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  CHEBI ontology 19614
    role 19557
      biological role 19550
        pharmacological role 18676
          antagonist 15766
            GABA antagonist 3329
              flumazenil 8
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  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      chalcogen 19201
                        oxygen atom 19155
                          oxygen molecular entity 19155
                            hydroxides 18944
                              organic hydroxy compound 18464
                                alcohol 14771
                                  primary alcohol 13738
                                    ethanols 7926
                                      ethanol 7926
                                        ethyl ester 3054
                                          flumazenil 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.