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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flumazenil
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Accession:CHEBI:5103 term browser browse the term
Definition:An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Synonyms:exact_synonym: ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
 related_synonym: Anexate;   Formula=C15H14FN3O3;   InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3;   InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N;   Lanexat;   SMILES=C1=NC(=C2N1C=3C(C(N(C2)C)=O)=CC(=CC3)F)C(OCC)=O;   flumazenilo;   flumazenilum
 xref: Beilstein:4763661;   CAS:78755-81-4;   DrugBank:DB01205;   Drug_Central:1195;   HMDB:HMDB0015336;   KEGG:C07825;   KEGG:D00697;   LINCS:LSM-4228
 xref_mesh: MESH:D005442
 xref: PMID:11881583;   PMID:23126253;   PMID:23431889;   PMID:24563235;   PMID:26324010;   PMID:26469689;   Reaxys:4763661;   Wikipedia:Flumazenil


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flumazenil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069, PMID:17403139 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions EXP Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 mRNA]; Flumazenil inhibits the reaction [Ethanol deficiency results in increased expression of GABRA4 protein] CTD PMID:17403139 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions
affects binding
ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8632757 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Flumazenil promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein]] CTD PMID:1977069 NCBI chr14:38,631,192...39,112,598
Ensembl chr14:38,643,385...39,112,600
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 affects binding
multiple interactions
ISO Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:8632757 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions
affects binding
ISO Flumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
Flumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD PMID:8632757 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Flumazenil inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tspo translocator protein multiple interactions ISO [Flumazenil binds to and results in decreased activity of TSPO protein] which results in decreased susceptibility to Nicotine CTD PMID:7862733 NCBI chr 7:124,460,358...124,470,610
Ensembl chr 7:124,460,358...124,470,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        pharmacological role 18795
          antagonist 16192
            GABA antagonist 3487
              flumazenil 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      chalcogen 19359
                        oxygen atom 19320
                          oxygen molecular entity 19320
                            hydroxides 19064
                              organic hydroxy compound 18631
                                alcohol 14979
                                  primary alcohol 13881
                                    ethanols 8106
                                      ethanol 8106
                                        ethyl ester 3173
                                          flumazenil 8
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