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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flucloxacillin
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Accession:CHEBI:5098 term browser browse the term
Definition:A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain.
Synonyms:exact_synonym: 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido]-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin;   Floxacillin;   Floxapen;   Formula=C19H17ClFN3O5S;   InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1;   InChIKey=UIOFUWFRIANQPC-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(F)cccc1Cl)C(O)=O;   flucloxacilina;   flucloxacilline;   flucloxacillinum
 xref: Beilstein:4771988;   CAS:5250-39-5;   DrugBank:DB00301;   Drug_Central:1183;   KEGG:C11748;   KEGG:D04196
 xref_mesh: MESH:D005436
 xref: PMID:12569987;   PMID:15773973;   PMID:23032409;   PMID:23542420;   PMID:25998949;   PMID:29017833;   PMID:5481218;   Reaxys:4771988;   Wikipedia:Flucloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:52037



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flucloxacillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions
ISO Floxacillin results in decreased activity of ABCB11 protein
Floxacillin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G Akr1b10 aldo-keto reductase family 1, member B10 increases expression ISO Floxacillin results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885
JBrowse link
G Alb albumin affects binding ISO Floxacillin binds to ALB protein CTD PMID:36782357 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Floxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein] CTD PMID:30876886 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Floxacillin results in increased expression of CCL2 mRNA CTD PMID:24652713 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Cd69 CD69 antigen multiple interactions EXP [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of CD69 protein CTD PMID:30993380 NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399
JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Floxacillin binds to CES1 protein CTD PMID:36782357 NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466
JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 affects binding ISO Floxacillin binds to CPS1 protein CTD PMID:36782357 NCBI chr 1:67,151,294...67,270,426
Ensembl chr 1:67,162,185...67,270,418
JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO [Floxacillin co-treated with Gentamicins co-treated with Rifampin] results in increased expression of CRP protein CTD PMID:16943303 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Floxacillin results in increased expression of CXCL2 mRNA CTD PMID:24652713 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression EXP Floxacillin results in increased expression of CXCL1 mRNA CTD PMID:24652713 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459
JBrowse link
G Fasl Fas ligand multiple interactions EXP [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of FASL protein; FASL protein affects the reaction [[Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein] CTD PMID:30993380 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064
JBrowse link
G Glud1 glutamate dehydrogenase 1 affects binding ISO Floxacillin binds to GLUD1 protein CTD PMID:36782357 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases expression
EXP [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein; [Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein; FASL protein affects the reaction [[Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein]; IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein] CTD PMID:24652713 PMID:30993380 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 affects response to substance ISO HLA-B gene polymorphism affects the susceptibility to Floxacillin CTD PMID:19483685 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 affects binding ISO Floxacillin binds to HBA2 protein CTD PMID:36782357 NCBI chr11:32,246,492...32,247,310
Ensembl chr11:32,246,489...32,247,298
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain affects binding ISO Floxacillin binds to HBB protein CTD PMID:36782357
G Hmgb1 high mobility group box 1 increases secretion
increases expression
ISO
EXP
Floxacillin results in increased secretion of HMGB1 protein
Floxacillin results in increased expression of HMGB1 protein
CTD PMID:24652713 PMID:28444390 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Il17a interleukin 17A multiple interactions EXP [IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein; IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein] CTD PMID:24652713 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720
JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO Floxacillin results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
multiple interactions
ISO
EXP
Floxacillin results in increased secretion of IL1B protein
Floxacillin results in increased expression of IL1B mRNA
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il5 interleukin 5 increases expression EXP Floxacillin results in increased expression of IL5 mRNA CTD PMID:24652713 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
multiple interactions
ISO
EXP
Floxacillin results in increased secretion of IL6 protein
Floxacillin results in increased expression of IL6 mRNA
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Klrb1c killer cell lectin-like receptor subfamily B member 1C multiple interactions EXP [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of KLRB1C protein CTD PMID:30993380 NCBI chr 6:128,755,448...128,765,514
Ensembl chr 6:128,755,448...128,766,178
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein CTD PMID:24652713 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Rorc RAR-related orphan receptor gamma increases expression EXP Floxacillin results in increased expression of RORC mRNA CTD PMID:24652713 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583
JBrowse link
G S100a8 S100 calcium binding protein A8 (calgranulin A) increases expression EXP Floxacillin results in increased expression of S100A8 mRNA CTD PMID:24652713 NCBI chr 3:90,576,378...90,577,341
Ensembl chr 3:90,576,285...90,577,342
JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression EXP Floxacillin results in increased expression of S100A9 mRNA CTD PMID:24652713 NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028
JBrowse link
G Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) increases expression ISO Floxacillin results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296
JBrowse link
G Tbx21 T-box 21 decreases expression EXP Floxacillin results in decreased expression of TBX21 mRNA CTD PMID:24652713 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
multiple interactions
ISO
EXP
Floxacillin results in increased secretion of TNF protein
Floxacillin results in increased expression of TNF mRNA
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tsen2 tRNA splicing endonuclease subunit 2 affects binding ISO Floxacillin binds to TSEN2 protein CTD PMID:36782357 NCBI chr 6:115,521,652...115,555,297
Ensembl chr 6:115,521,625...115,555,589
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Floxacillin results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 affects binding ISO Floxacillin binds to UGP2 protein CTD PMID:36782357 NCBI chr11:21,271,126...21,321,267
Ensembl chr11:21,271,138...21,321,201
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide affects binding ISO Floxacillin binds to YWHAB protein CTD PMID:36782357 NCBI chr 2:163,837,082...163,860,508
Ensembl chr 2:163,836,880...163,860,508
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        aetiopathogenetic role 21283
          allergen 18778
            penicillin 313
              flucloxacillin 35
                flucloxacilloyl group + 0
                flucloxacilloyl-L-lysine + 0
                flucloxcillanyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      carboacyl group 18299
                                        univalent carboacyl group 18299
                                          carbamoyl group 18110
                                            carboxamide 18110
                                              lactam 8460
                                                beta-lactam 814
                                                  beta-lactam antibiotic 798
                                                    penams 313
                                                      penicillanic acids 313
                                                        penicillanic acid 313
                                                          6-aminopenicillanic acid 313
                                                            penicillin 313
                                                              penicillin allergen 310
                                                                flucloxacillin 35
                                                                  flucloxacilloyl group + 0
                                                                  flucloxacilloyl-L-lysine + 0
                                                                  flucloxcillanyl group 0
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