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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flucloxacillin
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Accession:CHEBI:5098 term browser browse the term
Definition:A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain.
Synonyms:exact_synonym: 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido]-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin;   Floxacillin;   Floxapen;   Formula=C19H17ClFN3O5S;   InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1;   InChIKey=UIOFUWFRIANQPC-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(F)cccc1Cl)C(O)=O;   flucloxacilina;   flucloxacilline;   flucloxacillinum
 xref: Beilstein:4771988;   CAS:5250-39-5;   DrugBank:DB00301;   Drug_Central:1183;   KEGG:C11748;   KEGG:D04196
 xref_mesh: MESH:D005436
 xref: PMID:12569987;   PMID:15773973;   PMID:23032409;   PMID:23542420;   PMID:25998949;   PMID:29017833;   PMID:5481218;   Reaxys:4771988;   Wikipedia:Flucloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:52037


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flucloxacillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Floxacillin results in decreased activity of ABCB11 protein
Floxacillin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Floxacillin results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Floxacillin results in increased activity of CASP3 protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Floxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
CTD PMID:30876886 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Floxacillin results in increased expression of CCL2 mRNA CTD PMID:24652713 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of CD69 protein CTD PMID:30993380 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Floxacillin co-treated with Gentamicins co-treated with Rifampin] results in increased expression of CRP protein CTD PMID:16943303 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Floxacillin results in increased expression of CXCL2 mRNA CTD PMID:24652713 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Floxacillin results in increased expression of CXCL1 mRNA CTD PMID:24652713 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases metabolic processing ISO CYP3A4 results in increased metabolism of Floxacillin CTD PMID:11409940 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of FASL protein; FASL protein affects the reaction [[Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein] CTD PMID:30993380 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein; [Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein; FASL protein affects the reaction [[Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein]; IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein] CTD PMID:24652713 PMID:30993380 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hmgb1 high mobility group box 1 increases secretion
increases expression
ISO Floxacillin results in increased secretion of HMGB1 protein
Floxacillin results in increased expression of HMGB1 protein
CTD PMID:24652713 PMID:28444390 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein; IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein] CTD PMID:24652713 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO Floxacillin results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression
ISO Floxacillin results in increased secretion of IL1B protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
Floxacillin results in increased expression of IL1B mRNA
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il5 interleukin 5 increases expression ISO Floxacillin results in increased expression of IL5 mRNA CTD PMID:24652713 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO Floxacillin results in increased secretion of IL6 protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
Floxacillin results in increased expression of IL6 mRNA
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein CTD PMID:24652713 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO Floxacillin results in increased expression of RORC mRNA CTD PMID:24652713 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Floxacillin results in increased expression of S100A8 mRNA CTD PMID:24652713 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Floxacillin results in increased expression of S100A9 mRNA CTD PMID:24652713 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Floxacillin results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Floxacillin results in decreased expression of TBX21 mRNA CTD PMID:24652713 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression
ISO Floxacillin results in increased secretion of TNF protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
Floxacillin results in increased expression of TNF mRNA
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Floxacillin results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19783
    role 19728
      biological role 19728
        aetiopathogenetic role 18977
          allergen 17260
            penicillin 263
              flucloxacillin 25
                flucloxacilloyl group + 0
                flucloxacilloyl-L-lysine + 0
                flucloxcillanyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19783
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18606
                              organic divalent group 18597
                                organodiyl group 18597
                                  carbonyl group 18510
                                    carbonyl compound 18510
                                      carboxylic acid 18163
                                        carboacyl group 17417
                                          univalent carboacyl group 17417
                                            carbamoyl group 17213
                                              carboxamide 17213
                                                lactam 8048
                                                  beta-lactam 794
                                                    beta-lactam antibiotic 779
                                                      penams 263
                                                        penicillanic acids 263
                                                          penicillanic acid 263
                                                            6-aminopenicillanic acid 263
                                                              penicillin 263
                                                                penicillin allergen 260
                                                                  flucloxacillin 25
                                                                    flucloxacilloyl group + 0
                                                                    flucloxacilloyl-L-lysine + 0
                                                                    flucloxcillanyl group 0
paths to the root