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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:flucloxacillin
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Accession:CHEBI:5098 term browser browse the term
Definition:A penicillin compound having a 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido] side-chain.
Synonyms:exact_synonym: 6beta-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxamido]-2,2-dimethylpenam-3alpha-carboxylic acid
 related_synonym: (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;   3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin;   Floxacillin;   Floxapen;   Formula=C19H17ClFN3O5S;   InChI=1S/C19H17ClFN3O5S/c1-7-10(12(23-29-7)11-8(20)5-4-6-9(11)21)15(25)22-13-16(26)24-14(18(27)28)19(2,3)30-17(13)24/h4-6,13-14,17H,1-3H3,(H,22,25)(H,27,28)/t13-,14+,17-/m1/s1;   InChIKey=UIOFUWFRIANQPC-JKIFEVAISA-N;   SMILES=[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c1c(C)onc1-c1c(F)cccc1Cl)C(O)=O;   flucloxacilina;   flucloxacilline;   flucloxacillinum
 xref: Beilstein:4771988;   CAS:5250-39-5;   DrugBank:DB00301;   Drug_Central:1183;   KEGG:C11748;   KEGG:D04196
 xref_mesh: MESH:D005436
 xref: PMID:12569987;   PMID:15773973;   PMID:23032409;   PMID:23542420;   PMID:25998949;   PMID:29017833;   PMID:5481218;   Reaxys:4771988;   Wikipedia:Flucloxacillin
 cyclic_relationship: is_conjugate_acid_of CHEBI:52037



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flucloxacillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Floxacillin results in decreased activity of ABCB11 protein
Floxacillin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Floxacillin results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Floxacillin results in increased activity of CASP3 protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [Floxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
CTD PMID:30876886 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Floxacillin results in increased expression of CCL2 mRNA CTD PMID:24652713 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of CD69 protein CTD PMID:30993380 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Floxacillin co-treated with Gentamicins co-treated with Rifampin] results in increased expression of CRP protein CTD PMID:16943303 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Floxacillin results in increased expression of CXCL2 mRNA CTD PMID:24652713 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Floxacillin results in increased expression of CXCL1 mRNA CTD PMID:24652713 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 results in increased metabolism of Floxacillin CTD PMID:11409940 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Faslg Fas ligand multiple interactions ISO [Floxacillin co-treated with CpG ODN 1826] results in decreased expression of FASL protein; FASL protein affects the reaction [[Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein] CTD PMID:30993380 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression
ISO [Floxacillin co-treated with alpha-galactosylceramide] results in increased expression of GPT protein; [Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein; FASL protein affects the reaction [[Floxacillin co-treated with CpG ODN 1826] results in increased expression of GPT protein]; IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein] CTD PMID:24652713 PMID:30993380 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmgb1 high mobility group box 1 increases secretion
increases expression
ISO Floxacillin results in increased secretion of HMGB1 protein
Floxacillin results in increased expression of HMGB1 protein
CTD PMID:24652713 PMID:28444390 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein; IL17A protein promotes the reaction [Floxacillin results in increased expression of GPT protein] CTD PMID:24652713 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO Floxacillin results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression
ISO Floxacillin results in increased secretion of IL1B protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL1B protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
Floxacillin results in increased expression of IL1B mRNA
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il5 interleukin 5 increases expression ISO Floxacillin results in increased expression of IL5 mRNA CTD PMID:24652713 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO Floxacillin results in increased secretion of IL6 protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with IL6 protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
Floxacillin results in increased expression of IL6 mRNA
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [IL17A protein co-treated with Floxacillin] results in increased expression of MPO protein CTD PMID:24652713 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Rorc RAR-related orphan receptor C increases expression ISO Floxacillin results in increased expression of RORC mRNA CTD PMID:24652713 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 affects response to substance ISO HLA-B gene polymorphism affects the susceptibility to Floxacillin CTD PMID:19483685 NCBI chr20:4,905,309...4,914,593 JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Floxacillin results in increased expression of S100A8 mRNA CTD PMID:24652713 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Floxacillin results in increased expression of S100A9 mRNA CTD PMID:24652713 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Floxacillin results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Floxacillin results in decreased expression of TBX21 mRNA CTD PMID:24652713 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression
ISO Floxacillin results in increased secretion of TNF protein
[Floxacillin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Floxacillin co-treated with TNF protein] results in increased activity of CASP3 protein; [TNF protein co-treated with IL6 protein co-treated with IL1B protein] promotes the reaction [Floxacillin results in increased activity of CASP3 protein]
Floxacillin results in increased expression of TNF mRNA
CTD PMID:24652713 PMID:28444390 PMID:30876886 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Floxacillin results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        aetiopathogenetic role 19275
          allergen 17518
            penicillin 262
              flucloxacillin 26
                flucloxacilloyl group + 0
                flucloxacilloyl-L-lysine + 0
                flucloxcillanyl group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                lactam 8343
                                                  beta-lactam 795
                                                    beta-lactam antibiotic 780
                                                      penams 262
                                                        penicillanic acids 262
                                                          penicillanic acid 262
                                                            6-aminopenicillanic acid 262
                                                              penicillin 262
                                                                penicillin allergen 259
                                                                  flucloxacillin 26
                                                                    flucloxacilloyl group + 0
                                                                    flucloxacilloyl-L-lysine + 0
                                                                    flucloxcillanyl group 0
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