CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor |
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Accession: | CHEBI:50925
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browse the term
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Definition: | An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. |
Synonyms: | related_synonym: | A-kinase inhibitor; A-kinase inhibitors; AP50 kinase inhibitor; AP50 kinase inhibitors; ATP-protein transphosphorylase inhibitor; ATP-protein transphosphorylase inhibitors; ATP:protein phosphotransferase (non-specific) inhibitor; ATP:protein phosphotransferase (non-specific) inhibitors; BR serine/threonine-protein kinase 2 inhibitor; BR serine/threonine-protein kinase 2 inhibitors; CK-2 inhibitor; CK-2 inhibitors; CKI inhibitor; CKI inhibitors; CKII inhibitor; CKII inhibitors; EC 2.7.11.1 inhibitor; EC 2.7.11.1 inhibitors; HIPK2 inhibitor; HIPK2 inhibitors; Hpr kinase inhibitor; Hpr kinase inhibitors; M phase-specific cdc2 kinase inhibitor; M phase-specific cdc2 kinase inhibitors; MKNK2 inhibitor; MKNK2 inhibitors; PAK-1 inhibitor; PAK-1 inhibitors; PAK1 inhibitor; PAK1 inhibitors; PKA inhibitor; PKA inhibitors; Prp4 protein kinase inhibitor; Prp4 protein kinase inhibitors; Raf kinase inhibitor; Raf kinase inhibitors; Raf-1 inhibitor; Raf-1 inhibitors; STK32 inhibitor; STK32 inhibitors; T-antigen kinase inhibitor; T-antigen kinase inhibitors; WEE1Hu inhibitor; WEE1Hu inhibitors; Wee 1-like kinase inhibitor; Wee 1-like kinase inhibitors; Wee-kinase inhibitor; Wee-kinase inhibitors; betaIIPKC inhibitor; betaIIPKC inhibitors; cAMP-dependent protein kinase A inhibitor; cAMP-dependent protein kinase A inhibitors; cAMP-dependent protein kinase inhibitor; cAMP-dependent protein kinase inhibitors; cGMP-dependent protein kinase inhibitor; cGMP-dependent protein kinase inhibitors; calcium-dependent protein kinase C inhibitor; calcium-dependent protein kinase C inhibitors; calcium/phospholipid-dependent protein kinase inhibitor; calcium/phospholipid-dependent protein kinase inhibitors; casein kinase (phosphorylating) inhibitor; casein kinase (phosphorylating) inhibitors; casein kinase 2 inhibitor; casein kinase 2 inhibitors; casein kinase I inhibitor; casein kinase I inhibitors; casein kinase II inhibitor; casein kinase II inhibitors; casein kinase inhibitor; casein kinase inhibitors; cyclic AMP-dependent protein kinase A inhibitor; cyclic AMP-dependent protein kinase A inhibitors; cyclic AMP-dependent protein kinase inhibitor; cyclic AMP-dependent protein kinase inhibitors; cyclic monophosphate-dependent protein kinase inhibitor; cyclic monophosphate-dependent protein kinase inhibitors; cyclic nucleotide-dependent protein kinase inhibitor; cyclic nucleotide-dependent protein kinase inhibitors; cyclin-dependent kinase inhibitor; cyclin-dependent kinase inhibitors; dsk1 inhibitor; dsk1 inhibitors; epsilon PKC inhibitor; epsilon PKC inhibitors; glycogen synthase a kinase inhibitor; glycogen synthase a kinase inhibitors; glycogen synthase kinase inhibitor; glycogen synthase kinase inhibitors; hydroxyalkyl-protein kinase inhibitor; hydroxyalkyl-protein kinase inhibitors; mitogen-activated S6 kinase inhibitor; mitogen-activated S6 kinase inhibitors; non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors; non-specific serine/threonine protein kinase inhibitor; non-specific serine/threonine protein kinase inhibitors; p21 activated kinase-1 inhibitor; p21 activated kinase-1 inhibitors; p82 kinase inhibitor; p82 kinase inhibitors; phosphorylase b kinase kinase inhibitor; phosphorylase b kinase kinase inhibitors; protein glutamyl kinase inhibitor; protein glutamyl kinase inhibitors; protein kinase (phosphorylating) inhibitor; protein kinase (phosphorylating) inhibitors; protein kinase A inhibitor; protein kinase A inhibitors; protein kinase CK2 inhibitor; protein kinase CK2 inhibitors; protein kinase p58 inhibitor; protein kinase p58 inhibitors; protein phosphokinase inhibitor; protein phosphokinase inhibitors; protein serine kinase inhibitor; protein serine kinase inhibitors; protein-aspartyl kinase inhibitor; protein-aspartyl kinase inhibitors; protein-cysteine kinase inhibitor; protein-cysteine kinase inhibitors; ribosomal S6 protein kinase inhibitor; ribosomal S6 protein kinase inhibitors; ribosomal protein S6 kinase II inhibitor; ribosomal protein S6 kinase II inhibitors; serine kinase inhibitor; serine kinase inhibitors; serine-specific protein kinase inhibitor; serine-specific protein kinase inhibitors; serine/threonine protein kinase inhibitor; serine/threonine protein kinase inhibitors; threonine-specific protein kinase inhibitor; threonine-specific protein kinase inhibitors; twitchin kinase inhibitor; twitchin kinase inhibitors; type-2 casein kinase inhibitor; type-2 casein kinase inhibitors |
| alt_id: | CHEBI:75764 |
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Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases expression |
ISO EXP |
6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of ABCB1 protein 6-bromoindirubin-3'-oxime results in increased expression of ABCB1 mRNA 6-bromoindirubin-3'-oxime results in increased expression of ABCB1A mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCB1A protein |
CTD |
PMID:18624906 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
6-bromoindirubin-3'-oxime results in increased expression of ABCC2 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCC2 protein |
CTD |
PMID:18624906 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
6-bromoindirubin-3'-oxime results in increased expression of ABCC4 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCC4 protein |
CTD |
PMID:18624906 |
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NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
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Abcg2 |
ATP binding cassette subfamily G member 2 |
increases expression |
ISO |
6-bromoindirubin-3'-oxime results in increased expression of ABCG2 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCG2 protein |
CTD |
PMID:18624906 |
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NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime binds to and results in increased activity of AHR protein |
CTD |
PMID:26259606 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
[sorafenib co-treated with 6-bromoindirubin-3'-oxime] affects the localization of AIFM1 protein |
CTD |
PMID:17991738 |
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NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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Casp8 |
caspase 8 |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form] |
CTD |
PMID:28414160 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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Ccnd1 |
cyclin D1 |
increases expression |
ISO EXP |
6-bromoindirubin-3'-oxime results in increased expression of CCND1 mRNA |
CTD |
PMID:18624906 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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Cdx1 |
caudal type homeo box 1 |
multiple interactions |
ISO |
[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in increased expression of CDX1 mRNA |
CTD |
PMID:27693483 |
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NCBI chr18:56,337,485...56,355,477
Ensembl chr18:56,338,336...56,355,490
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Ctnnb1 |
catenin beta 1 |
multiple interactions increases expression decreases phosphorylation |
ISO |
[6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein; broussochalcone A inhibits the reaction [6-bromoindirubin-3'-oxime results in increased expression of CTNNB1 protein]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in decreased phosphorylation of CTNNB1 protein] |
CTD |
PMID:18624906 PMID:19727391 PMID:26259606 PMID:31163223 |
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NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression multiple interactions |
ISO |
6-bromoindirubin-3'-oxime results in increased expression of CYP1A2 mRNA 6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of CYP1A2 protein |
CTD |
PMID:26259606 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of CYP26A1 mRNA |
CTD |
PMID:27693483 |
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NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
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Ddx3x |
DEAD-box helicase 3, X-linked |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to DDX3X protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of DDX3X protein modified form] |
CTD |
PMID:28414160 |
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NCBI chr X:10,400,363...10,414,010
Ensembl chr X:10,400,366...10,413,995
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Dhfr |
dihydrofolate reductase |
multiple interactions |
ISO |
[6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein |
CTD |
PMID:19727391 |
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NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
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Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime promotes the reaction [sorafenib affects the localization of DIABLO protein] |
CTD |
PMID:17991738 |
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NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
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Gsk3a |
glycogen synthase kinase 3 alpha |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3A protein modified form] |
CTD |
PMID:28414160 |
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NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
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Gsk3b |
glycogen synthase kinase 3 beta |
decreases activity multiple interactions increases phosphorylation |
ISO |
6-bromoindirubin-3'-oxime results in decreased activity of GSK3B protein 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:17991738 PMID:19727391 PMID:28414160 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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Hoxa1 |
homeobox A1 |
multiple interactions |
ISO |
[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of HOXA1 mRNA |
CTD |
PMID:27693483 |
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NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
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Il6 |
interleukin 6 |
multiple interactions |
ISO |
[6-bromoindirubin-3'-oxime co-treated with Methotrexate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:19727391 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Lgr5 |
leucine rich repeat containing G protein coupled receptor 5 |
increases expression |
ISO |
6-bromoindirubin-3'-oxime results in increased expression of LGR5 mRNA |
CTD |
PMID:26259606 |
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NCBI chr 7:58,447,097...58,587,787
Ensembl chr 7:58,448,277...58,587,787
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Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
6-bromoindirubin-3'-oxime results in decreased expression of MCL1 protein |
CTD |
PMID:17991738 |
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NCBI chr 2:197,786,212...197,788,992
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Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of PARP1 protein modified form] |
CTD |
PMID:28414160 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
multiple interactions |
ISO |
6-bromoindirubin-3'-oxime inhibits the reaction [sorafenib results in decreased expression of PMAIP1 protein] |
CTD |
PMID:17991738 |
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NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
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Pou5f1 |
POU class 5 homeobox 1 |
multiple interactions |
ISO |
[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of POU5F1 mRNA |
CTD |
PMID:27693483 |
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NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
[6-bromoindirubin-3'-oxime co-treated with Methotrexate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:19727391 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Wnt3 |
Wnt family member 3 |
multiple interactions |
ISO |
[Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of WNT3 mRNA |
CTD |
PMID:27693483 |
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NCBI chr10:91,830,709...91,874,907
Ensembl chr10:91,830,654...91,874,793
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Adora2a |
adenosine A2a receptor |
multiple interactions increases response to substance |
EXP ISO |
8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein] ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine |
CTD |
PMID:11172060 PMID:15641640 PMID:18608257 PMID:19966059 PMID:21195062 |
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NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
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Drd2 |
dopamine receptor D2 |
affects response to substance multiple interactions |
ISO |
DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine] |
CTD |
PMID:11172060 |
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NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
EXP |
8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] |
CTD |
PMID:8577368 PMID:10199625 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] |
CTD |
PMID:19966059 |
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NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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Nts |
neurotensin |
multiple interactions |
EXP |
8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] |
CTD |
PMID:10199625 |
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NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
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Ar |
androgen receptor |
increases activity |
ISO |
alsterpaullone analog results in increased activity of AR protein |
CTD |
PMID:21111724 |
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NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Casp3 |
caspase 3 |
multiple interactions |
EXP |
alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein] |
CTD |
PMID:20300959 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Cdk2 |
cyclin dependent kinase 2 |
decreases activity |
ISO |
alsterpaullone results in decreased activity of CDK2 protein |
CTD |
PMID:12534346 |
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NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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Gsk3b |
glycogen synthase kinase 3 beta |
decreases activity |
ISO |
alsterpaullone results in decreased activity of GSK3B protein |
CTD |
PMID:12534346 |
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NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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Lck |
LCK proto-oncogene, Src family tyrosine kinase |
decreases activity |
ISO |
alsterpaullone results in decreased activity of LCK protein |
CTD |
PMID:12534346 |
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NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
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Tp53 |
tumor protein p53 |
affects localization multiple interactions |
ISO |
alsterpaullone affects the localization of TP53 protein alsterpaullone results in decreased degradation of and results in increased expression of TP53 protein |
CTD |
PMID:16055726 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Abcb4 |
ATP binding cassette subfamily B member 4 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA |
CTD |
PMID:28843594 |
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NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
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Abcc2 |
ATP binding cassette subfamily C member 2 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA |
CTD |
PMID:28843594 |
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NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Abcc3 |
ATP binding cassette subfamily C member 3 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA |
CTD |
PMID:28843594 |
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NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
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Acan |
aggrecan |
decreases expression |
EXP |
Caffeine results in decreased expression of ACAN mRNA |
CTD |
PMID:29966748 PMID:32663519 |
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NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441
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Acat2 |
acetyl-CoA acetyltransferase 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of ACAT2 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
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Ace |
angiotensin I converting enzyme |
increases expression decreases methylation |
EXP |
Caffeine results in increased expression of ACE mRNA; Caffeine results in increased expression of ACE protein Caffeine results in decreased methylation of ACE promoter |
CTD |
PMID:30423288 |
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NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
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Ache |
acetylcholinesterase |
multiple interactions decreases activity |
EXP |
caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein] |
CTD |
PMID:28465162 |
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NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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Acin1 |
apoptotic chromatin condensation inducer 1 |
increases expression |
ISO |
Caffeine results in increased expression of ACIN1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417
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Acly |
ATP citrate lyase |
increases expression |
EXP |
Caffeine results in increased expression of ACLY mRNA |
CTD |
PMID:30776459 |
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NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
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Acsl3 |
acyl-CoA synthetase long-chain family member 3 |
increases expression |
ISO |
Caffeine results in increased expression of ACSL3 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
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Acsl4 |
acyl-CoA synthetase long-chain family member 4 |
decreases expression |
ISO |
Caffeine results in decreased expression of ACSL4 protein |
CTD |
PMID:31195006 |
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NCBI chr X:113,596,247...113,660,024
Ensembl chr X:113,596,239...113,659,944
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Acta2 |
actin alpha 2, smooth muscle |
increases expression |
EXP |
Caffeine results in increased expression of ACTA2 mRNA |
CTD |
PMID:29055810 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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Actb |
actin, beta |
decreases expression |
ISO |
Caffeine results in decreased expression of ACTB protein |
CTD |
PMID:31195006 |
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NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
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Actbl2 |
actin, beta-like 2 |
increases expression |
ISO |
Caffeine results in increased expression of ACTBL2 protein |
CTD |
PMID:31195006 |
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NCBI chr 2:42,829,413...42,832,160
Ensembl chr 2:42,829,413...42,832,160
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Actl6b |
actin-like 6B |
increases expression |
ISO |
Caffeine results in increased expression of ACTL6B protein |
CTD |
PMID:31195006 |
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NCBI chr12:22,194,595...22,211,107
Ensembl chr12:22,194,618...22,211,080
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Actr1a |
actin related protein 1A |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:266,123,864...266,142,621
Ensembl chr 1:266,123,870...266,142,538
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G |
Ada |
adenosine deaminase |
increases expression |
EXP |
Caffeine results in increased expression of ADA protein |
CTD |
PMID:6149265 |
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NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
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G |
Adamts5 |
ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
increases expression |
EXP |
Caffeine results in increased expression of ADAMTS5 mRNA |
CTD |
PMID:31874197 |
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NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836
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G |
Adarb1 |
adenosine deaminase, RNA-specific, B1 |
decreases expression |
EXP |
Caffeine results in decreased expression of ADARB1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047
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G |
Adcy5 |
adenylate cyclase 5 |
decreases expression |
EXP |
Caffeine results in decreased expression of ADCY5 mRNA |
CTD |
PMID:26367767 |
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NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
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G |
Adcy7 |
adenylate cyclase 7 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
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G |
Adgrl1 |
adhesion G protein-coupled receptor L1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:25,029,037...25,069,146
Ensembl chr19:25,029,037...25,069,142
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G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
Caffeine results in increased expression of ADIPOR2 mRNA |
CTD |
PMID:22583948 |
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NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
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G |
Adora1 |
adenosine A1 receptor |
multiple interactions decreases expression decreases activity increases expression |
ISO EXP |
[8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA Caffeine deficiency results in decreased expression of ADORA1 mRNA Caffeine results in decreased activity of ADORA1 protein Caffeine results in decreased expression of ADORA1 mRNA Caffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein] Caffeine results in increased expression of ADORA1 protein |
CTD |
PMID:3003150 PMID:7996441 PMID:10401785 PMID:12153486 PMID:15708489 PMID:22164264 PMID:23611293 PMID:29107002 PMID:29882086 |
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NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
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G |
Adora2a |
adenosine A2a receptor |
affects response to substance decreases expression multiple interactions decreases activity increases response to substance affects binding |
ISO EXP |
ADORA2A protein affects the susceptibility to Caffeine Caffeine results in decreased expression of ADORA2A mRNA Caffeine results in decreased expression of ADORA2A mRNA; Caffeine results in decreased expression of ADORA2A protein 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein] ADORA2A polymorphism affects the susceptibility to Caffeine Caffeine results in decreased activity of ADORA2A protein ADORA2A polymorphism results in increased susceptibility to Caffeine; ADORA2A SNP results in increased susceptibility to Caffeine Caffeine analog binds to and results in decreased activity of ADORA2A protein Caffeine analog binds to and results in decreased activity of ADORA2A protein; Caffeine binds to and results in decreased activity of ADORA2A protein Caffeine analog binds to ADORA2A protein ADORA2A protein results in increased susceptibility to Caffeine |
CTD |
PMID:10214707 PMID:11172060 PMID:12077927 PMID:12825092 PMID:15452191 PMID:16221767 PMID:16470403 PMID:16771831 PMID:18305461 PMID:20520601 PMID:21950736 PMID:23611293 PMID:26367767 PMID:30555576 PMID:30825513 |
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NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
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G |
Adora2b |
adenosine A2B receptor |
multiple interactions decreases expression |
ISO EXP |
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA] Caffeine results in decreased expression of ADORA2B mRNA |
CTD |
PMID:22701600 PMID:26367767 |
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NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
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G |
Agt |
angiotensinogen |
increases expression |
EXP |
Caffeine results in increased expression of AGT protein |
CTD |
PMID:30423288 |
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NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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G |
Agtr1a |
angiotensin II receptor, type 1a |
increases expression decreases expression |
EXP |
Caffeine results in increased expression of AGTR1A Caffeine results in decreased expression of AGTR1A mRNA |
CTD |
PMID:25986755 PMID:30423288 |
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NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
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G |
Agtr2 |
angiotensin II receptor, type 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of AGTR2 mRNA; Caffeine results in decreased expression of AGTR2 protein |
CTD |
PMID:25986755 PMID:30423288 |
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NCBI chr X:119,389,480...119,393,845
Ensembl chr X:119,390,013...119,393,842
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G |
Ahcy |
adenosylhomocysteinase |
decreases expression |
ISO |
Caffeine results in decreased expression of AHCY protein |
CTD |
PMID:31195006 |
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NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
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G |
Akap9 |
A-kinase anchoring protein 9 |
decreases expression |
ISO |
Caffeine results in decreased expression of AKAP9 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
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G |
Akr1a1 |
aldo-keto reductase family 1 member A1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of AKR1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions affects expression decreases expression decreases phosphorylation increases phosphorylation decreases response to substance |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein] Caffeine affects the expression of AKT1 mRNA Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein] Caffeine results in decreased expression of AKT1 mRNA; Caffeine results in decreased expression of AKT1 protein modified form Caffeine results in decreased phosphorylation of AKT1 protein AKT1 results in decreased susceptibility to Caffeine |
CTD |
PMID:15126379 PMID:18201823 PMID:21081844 PMID:21561856 PMID:22974838 PMID:29966748 PMID:30528684 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
decreases expression |
ISO |
Caffeine results in decreased expression of ALDH18A1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425 Ensembl chr 1:259,641,676...259,674,425
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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G |
Aldh9a1 |
aldehyde dehydrogenase 9 family, member A1 |
increases expression |
EXP |
Caffeine results in increased expression of ALDH9A1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA |
CTD |
PMID:28843594 |
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NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
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G |
Alms1 |
ALMS1, centrosome and basal body associated protein |
decreases expression |
EXP |
Caffeine results in decreased expression of ALMS1 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
decreases expression |
EXP |
Caffeine results in decreased expression of ALPL mRNA |
CTD |
PMID:30423288 PMID:31874197 |
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NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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G |
Ang |
angiogenin |
decreases expression |
ISO |
Caffeine results in decreased expression of ANG mRNA |
CTD |
PMID:11793227 |
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NCBI chr15:28,022,926...28,028,636
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G |
Ankrd37 |
ankyrin repeat domain 37 |
decreases expression |
EXP |
Caffeine results in decreased expression of ANKRD37 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888
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G |
Anxa11 |
annexin A11 |
decreases expression |
ISO |
Caffeine results in decreased expression of ANXA11 protein |
CTD |
PMID:31195006 |
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NCBI chr16:3,867,193...3,912,043
Ensembl chr16:3,867,208...3,912,148
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G |
Anxa4 |
annexin A4 |
decreases expression |
ISO |
Caffeine results in decreased expression of ANXA4 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions decreases expression |
ISO EXP |
[Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein Caffeine results in decreased expression of APOA1 mRNA |
CTD |
PMID:16324916 PMID:25868845 |
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NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
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G |
Apoa2 |
apolipoprotein A2 |
multiple interactions decreases expression |
ISO EXP |
[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein Caffeine results in decreased expression of APOA2 mRNA |
CTD |
PMID:16324916 PMID:25868845 |
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NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
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G |
Apob |
apolipoprotein B |
multiple interactions decreases expression |
ISO EXP |
[Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein [Caffeine co-treated with Dietary Fats] results in increased expression of APOB mRNA Caffeine results in decreased expression of APOB mRNA |
CTD |
PMID:16324916 PMID:25868845 PMID:29800656 |
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NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
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G |
Apoc1 |
apolipoprotein C1 |
multiple interactions decreases expression |
ISO EXP |
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein Caffeine results in decreased expression of APOC1 mRNA |
CTD |
PMID:16324916 PMID:25868845 |
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NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
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G |
Apoc2 |
apolipoprotein C2 |
multiple interactions decreases expression |
ISO EXP |
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein Caffeine results in decreased expression of APOC2 mRNA |
CTD |
PMID:16324916 PMID:25868845 |
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NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
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G |
Apoc3 |
apolipoprotein C3 |
multiple interactions |
ISO |
[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein |
CTD |
PMID:16324916 |
|
NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498
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G |
Apom |
apolipoprotein M |
decreases expression |
EXP |
Caffeine results in decreased expression of APOM mRNA |
CTD |
PMID:25868845 |
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NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073
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G |
Arcn1 |
archain 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of ARCN1 protein |
CTD |
PMID:31195006 |
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NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892
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G |
Arf1 |
ADP-ribosylation factor 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
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G |
Arl6ip1 |
ADP-ribosylation factor like GTPase 6 interacting protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of ARL6IP1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675
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G |
Arrb2 |
arrestin, beta 2 |
increases expression |
EXP |
Caffeine results in increased expression of ARRB2 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
decreases expression |
ISO |
Caffeine results in decreased expression of ASNS mRNA |
CTD |
PMID:18444173 |
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NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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G |
Atg7 |
autophagy related 7 |
increases response to substance |
ISO |
ATG7 protein results in increased susceptibility to Caffeine; ATG7 results in increased susceptibility to Caffeine |
CTD |
PMID:21081844 |
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NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
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G |
Atm |
ATM serine/threonine kinase |
multiple interactions decreases activity |
ISO |
[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene] |
CTD |
PMID:10531013 PMID:11507241 PMID:15975956 PMID:18347191 PMID:19028473 PMID:19038232 PMID:20734998 PMID:20888899 PMID:22927544 PMID:23274516 PMID:31168028 |
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NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
affects response to substance |
ISO |
ATP2A2 protein affects the susceptibility to Caffeine |
CTD |
PMID:19328205 |
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NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
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G |
Atp5mf |
ATP synthase membrane subunit f |
decreases expression |
ISO |
Caffeine results in decreased expression of ATP5MF mRNA |
CTD |
PMID:11793227 |
|
NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
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G |
Atp6v0c |
ATPase H+ transporting V0 subunit C |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V0C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0C mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077
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G |
Atp6v1b2 |
ATPase H+ transporting V1 subunit B2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V1B2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V1B2 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
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G |
Atpaf1 |
ATP synthase mitochondrial F1 complex assembly factor 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of ATPAF1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 5:134,641,618...134,667,079
Ensembl chr 5:134,641,608...134,667,084
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G |
Atr |
ATR serine/threonine kinase |
multiple interactions affects activity |
ISO |
[[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] Caffeine affects the activity of ATR protein |
CTD |
PMID:11507241 PMID:15975956 PMID:18158334 PMID:20734998 |
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NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
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G |
Atrn |
attractin |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918
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G |
Avpr1a |
arginine vasopressin receptor 1A |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA |
CTD |
PMID:28843594 |
|
NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
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G |
Basp1 |
brain abundant, membrane attached signal protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of BASP1 protein |
CTD |
PMID:31195006 |
|
NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Caffeine results in increased expression of BAX protein [Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA |
CTD |
PMID:12811820 PMID:12907610 PMID:31756439 |
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NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bbc3 |
Bcl-2 binding component 3 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] |
CTD |
PMID:19028473 |
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NCBI chr 1:78,261,491...78,267,802
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
[Caffeine co-treated with bisphenol A] results in decreased expression of BCL2L1 mRNA |
CTD |
PMID:31756439 |
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NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
Caffeine inhibits the reaction [aluminum chloride results in decreased expression of BDNF mRNA] |
CTD |
PMID:26339337 |
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NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
ISO |
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein] 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein] |
CTD |
PMID:30555576 |
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NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
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G |
Bglap |
bone gamma-carboxyglutamate protein |
decreases expression |
EXP |
Caffeine results in decreased expression of BGLAP mRNA |
CTD |
PMID:30423288 PMID:31874197 |
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NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
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G |
Bhmt |
betaine-homocysteine S-methyltransferase |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA |
CTD |
PMID:28843594 |
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NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions |
ISO |
Caffeine inhibits the reaction [silybin results in increased cleavage of BID protein] |
CTD |
PMID:16777994 |
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NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
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G |
Bnip3 |
BCL2 interacting protein 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
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G |
Bub1 |
BUB1 mitotic checkpoint serine/threonine kinase |
multiple interactions |
ISO |
[Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form |
CTD |
PMID:21670593 |
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NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
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G |
C1r |
complement C1r |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829
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G |
C1s |
complement C1s |
multiple interactions |
ISO |
Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609
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G |
C2cd5 |
C2 calcium-dependent domain containing 5 |
increases expression |
EXP |
Caffeine results in increased expression of C2CD5 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 4:177,245,868...177,331,910
Ensembl chr 4:177,245,868...177,331,915
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G |
Cad |
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
increases expression |
EXP |
Caffeine results in increased expression of CAD protein |
CTD |
PMID:6149265 |
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NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284
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G |
Calm1 |
calmodulin 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CALM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
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G |
Calu |
calumenin |
decreases expression |
ISO |
Caffeine results in decreased expression of CALU mRNA |
CTD |
PMID:11793227 |
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NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111
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G |
Cand1 |
cullin-associated and neddylation-dissociated 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of CAND1 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:62,124,362...62,162,451
Ensembl chr 7:62,124,362...62,162,453
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G |
Capn1 |
calpain 1 |
multiple interactions |
ISO |
[Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] |
CTD |
PMID:19490937 |
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NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
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G |
Capn2 |
calpain 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of CAPN2 protein |
CTD |
PMID:31195006 |
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NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
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G |
Casp2 |
caspase 2 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP2 protein] |
CTD |
PMID:16777994 |
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NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
multiple interactions decreases expression increases expression increases cleavage increases activity affects cleavage |
ISO EXP |
[Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein Caffeine results in decreased expression of CASP3 protein modified form Caffeine results in increased expression of CASP3 mRNA Caffeine results in increased cleavage of CASP3 protein Caffeine results in increased activity of CASP3 protein [Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein Caffeine affects the cleavage of CASP3 protein |
CTD |
PMID:12378022 PMID:12395097 PMID:12907610 PMID:15537744 PMID:16522534 PMID:16777994 PMID:18201823 PMID:18283038 PMID:19242509 PMID:19490937 PMID:19815060 PMID:21081844 PMID:21229324 PMID:31874197 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP9 protein [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA] |
CTD |
PMID:16522534 PMID:16777994 PMID:20230807 |
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NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
multiple interactions decreases expression increases expression |
ISO EXP |
Caffeine inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein] Caffeine results in decreased expression of CAT mRNA Caffeine results in increased expression of CAT protein [Caffeine co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [Caffeine co-treated with Cadmium Chloride] results in increased expression of CAT protein |
CTD |
PMID:22154906 PMID:23099337 PMID:25868845 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cav1 |
caveolin 1 |
increases expression |
ISO |
Caffeine results in increased expression of CAV1 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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G |
Cav3 |
caveolin 3 |
decreases expression |
EXP |
Caffeine results in decreased expression of CAV3 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917
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G |
Cbx5 |
chromobox 5 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:144,819,673...144,865,014
Ensembl chr 7:144,819,420...144,837,583
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G |
Ccdc124 |
coiled-coil domain containing 124 |
increases expression |
ISO |
Caffeine results in increased expression of CCDC124 protein |
CTD |
PMID:31195006 |
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NCBI chr16:20,317,446...20,323,265
Ensembl chr16:20,317,446...20,323,265
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G |
Ccdc174 |
coiled-coil domain containing 174 |
decreases expression |
EXP |
Caffeine results in decreased expression of CCDC174 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 4:123,760,708...123,787,529
Ensembl chr 4:123,760,743...123,787,528
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression decreases expression |
ISO |
Caffeine results in increased expression of CCL3 mRNA Caffeine results in decreased expression of CCL3 mRNA |
CTD |
PMID:28089782 |
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NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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G |
Ccnb1 |
cyclin B1 |
multiple interactions increases expression |
ISO |
Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein] Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein] Caffeine results in increased expression of CCNB1 protein |
CTD |
PMID:9098629 PMID:19038232 PMID:20025956 |
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NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] |
CTD |
PMID:15126379 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Ccnf |
cyclin F |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CCNF mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNF mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
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G |
Ccng1 |
cyclin G1 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA |
CTD |
PMID:28843594 |
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NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
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G |
Ccnl2 |
cyclin L2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:173,256,301...173,268,279
Ensembl chr 5:173,256,637...173,276,169
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G |
Cct8 |
chaperonin containing TCP1 subunit 8 |
decreases expression |
ISO |
Caffeine results in decreased expression of CCT8 protein |
CTD |
PMID:31195006 |
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NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881
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G |
Cd36 |
CD36 molecule |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA |
CTD |
PMID:28843594 |
|
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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G |
Cd59 |
CD59 molecule |
increases expression |
ISO |
Caffeine results in increased expression of CD59 protein |
CTD |
PMID:31195006 |
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NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621
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G |
Cd9 |
CD9 molecule |
decreases expression |
ISO |
Caffeine results in decreased expression of CD9 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166
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G |
Cdc14b |
cell division cycle 14B |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA |
CTD |
PMID:28843594 |
|
NCBI chr17:1,709,703...1,797,732
Ensembl chr17:1,703,943...1,797,750
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G |
Cdc25b |
cell division cycle 25B |
increases expression |
EXP |
Caffeine results in increased expression of CDC25B mRNA |
CTD |
PMID:20864626 |
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NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
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G |
Cdc25c |
cell division cycle 25C |
decreases expression multiple interactions |
ISO |
Caffeine results in decreased expression of CDC25C protein Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein] |
CTD |
PMID:11835680 PMID:15975956 |
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NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
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G |
Cdh1 |
cadherin 1 |
increases expression |
EXP |
Caffeine results in increased expression of CDH1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
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G |
Cdh11 |
cadherin 11 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of CDK1 protein]; Caffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein Caffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein] |
CTD |
PMID:9098629 PMID:11835680 PMID:15975956 PMID:19038232 |
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NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases activity |
ISO |
Caffeine results in decreased activity of CDK2 protein |
CTD |
PMID:11835680 |
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NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions decreases expression |
ISO |
Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] Caffeine results in decreased expression of CDK4 mRNA |
CTD |
PMID:11793227 PMID:15126379 |
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NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions |
ISO |
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]] 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein] |
CTD |
PMID:17977830 PMID:18223691 PMID:18347191 PMID:19735649 PMID:21840268 PMID:22927544 PMID:23274516 PMID:30555576 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
affects methylation |
ISO |
Caffeine affects the methylation of CDKN2A gene |
CTD |
PMID:30924039 |
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NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression affects expression increases expression |
EXP |
Caffeine results in decreased expression of CEBPA mRNA Caffeine affects the expression of CEBPA mRNA Caffeine results in increased expression of CEBPA mRNA |
CTD |
PMID:23727198 PMID:30423288 PMID:30528684 PMID:30776459 |
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NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
decreases expression |
EXP |
Caffeine results in decreased expression of CEBPB mRNA |
CTD |
PMID:30528684 |
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NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
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G |
Cemip2 |
cell migration inducing hyaluronidase 2 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA |
CTD |
PMID:28843594 |
|
NCBI chr 1:239,397,322...239,474,931
Ensembl chr 1:239,398,043...239,474,931
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G |
Cetn3 |
centrin 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 2:12,101,473...12,115,009
Ensembl chr 2:12,102,487...12,115,009 Ensembl chr 2:12,102,487...12,115,009
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G |
Cfd |
complement factor D |
multiple interactions |
ISO |
[Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] |
CTD |
PMID:2307116 |
|
NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
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G |
Chek1 |
checkpoint kinase 1 |
multiple interactions increases phosphorylation decreases expression decreases phosphorylation |
ISO |
Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein] Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein] Caffeine results in decreased expression of CHEK1 protein modified form Caffeine results in decreased phosphorylation of CHEK1 protein |
CTD |
PMID:15975956 PMID:18158334 PMID:19261750 PMID:21505179 PMID:21561856 PMID:22403396 PMID:29074359 |
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NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions decreases activity |
ISO |
Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]; Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]] Caffeine results in decreased activity of CHEK2 protein |
CTD |
PMID:10531013 PMID:15975956 PMID:16777994 PMID:18158334 PMID:19038232 PMID:23274516 |
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NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
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G |
Ckmt1 |
creatine kinase, mitochondrial 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CKMT1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
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G |
Clic1 |
chloride intracellular channel 1 |
increases expression |
ISO |
Caffeine results in increased expression of CLIC1 protein |
CTD |
PMID:31195006 |
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NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166
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G |
Clstn1 |
calsyntenin 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:166,533,262...166,601,686
Ensembl chr 5:166,533,181...166,601,684
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G |
Cnn2 |
calponin 2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:12,782,459...12,787,977
Ensembl chr 7:12,782,491...12,787,750
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G |
Cobl |
cordon-bleu WH2 repeat protein |
affects expression |
EXP |
Caffeine affects the expression of COBL mRNA |
CTD |
PMID:20864626 |
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NCBI chr14:92,341,949...92,497,169
Ensembl chr14:92,342,957...92,577,936
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G |
Coch |
cochlin |
decreases expression |
EXP |
Caffeine results in decreased expression of COCH mRNA |
CTD |
PMID:20864626 |
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NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions decreases expression |
ISO EXP |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA] Caffeine results in decreased expression of COL1A1 mRNA |
CTD |
PMID:20230807 PMID:24275088 |
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NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Col2a1 |
collagen type II alpha 1 chain |
decreases expression |
EXP |
Caffeine results in decreased expression of COL2A1 mRNA; Caffeine results in decreased expression of COL2A1 protein |
CTD |
PMID:29966748 PMID:32663519 |
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NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
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G |
Comt |
catechol-O-methyltransferase |
multiple interactions |
ISO |
[Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA |
CTD |
PMID:29882086 |
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NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
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G |
Coq8a |
coenzyme Q8A |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COQ8A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COQ8A mRNA] |
CTD |
PMID:20230807 |
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NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419
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G |
Cort |
cortistatin |
decreases expression |
EXP |
Caffeine results in decreased expression of CORT protein |
CTD |
PMID:25868845 |
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NCBI chr 5:165,942,780...165,944,221
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G |
Cox7a2l |
cytochrome c oxidase subunit 7A2 like |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7A2L mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 6:6,695,807...6,709,790
Ensembl chr 6:6,695,827...6,709,783
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G |
Cox7c |
cytochrome c oxidase subunit 7C |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression |
EXP |
Caffeine results in decreased expression of CPT1A mRNA |
CTD |
PMID:30776459 |
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NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
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G |
Creb1 |
cAMP responsive element binding protein 1 |
decreases expression |
ISO EXP |
Caffeine results in decreased expression of CREB1 mRNA |
CTD |
PMID:26367767 |
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NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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G |
Crtc2 |
CREB regulated transcription coactivator 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of CRTC2 protein |
CTD |
PMID:31195006 |
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NCBI chr 2:189,615,928...189,625,646
Ensembl chr 2:189,615,948...189,626,051
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G |
Csnk2a2 |
casein kinase 2 alpha 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of CSNK2A2 mRNA |
CTD |
PMID:20864626 |
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NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043
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G |
Cst3 |
cystatin C |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CST3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
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G |
Cth |
cystathionine gamma-lyase |
multiple interactions |
EXP |
[Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA |
CTD |
PMID:29447158 |
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NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
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G |
Ctnnb1 |
catenin beta 1 |
increases mutagenesis multiple interactions |
EXP |
Caffeine results in increased mutagenesis of CTNNB1 gene Caffeine inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein] |
CTD |
PMID:18283038 PMID:30377735 |
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NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Ctsb |
cathepsin B |
multiple interactions |
ISO |
[Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA] |
CTD |
PMID:19490937 PMID:20230807 |
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NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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G |
Ctsd |
cathepsin D |
increases expression |
ISO |
Caffeine results in increased expression of CTSD protein |
CTD |
PMID:31195006 |
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NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
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G |
Ctsl |
cathepsin L |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] |
CTD |
PMID:20230807 |
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NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
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G |
Cwc25 |
CWC25 spliceosome-associated protein homolog |
decreases expression |
ISO |
Caffeine results in decreased expression of CWC25 protein |
CTD |
PMID:31195006 |
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NCBI chr10:85,684,898...85,709,568
Ensembl chr10:85,684,898...85,709,568
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G |
Cxcl12 |
C-X-C motif chemokine ligand 12 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA |
CTD |
PMID:28843594 |
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NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
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G |
Cyc1 |
cytochrome c-1 |
decreases expression |
ISO |
Caffeine results in decreased expression of CYC1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
ISO |
Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] |
CTD |
PMID:19028473 |
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NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of CYP11A1 mRNA |
CTD |
PMID:24717552 PMID:25868845 |
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NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
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G |
Cyp11b2 |
cytochrome P450, family 11, subfamily b, polypeptide 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of CYP11B1 mRNA |
CTD |
PMID:25868845 PMID:29343424 PMID:30528684 |
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NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167
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G |
Cyp11b3 |
cytochrome P450, family 11, subfamily b, polypeptide 3 |
decreases expression |
EXP |
Caffeine results in decreased expression of CYP11B2 mRNA |
CTD |
PMID:25868845 PMID:29343424 |
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NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
increases expression |
EXP |
Caffeine results in increased expression of CYP17A1 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
increases expression |
EXP |
Caffeine results in increased expression of CYP19A1 mRNA; Caffeine results in increased expression of CYP19A1 protein |
CTD |
PMID:28111094 |
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NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Caffeine results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
affects binding multiple interactions increases metabolic processing decreases activity affects metabolic processing increases activity decreases methylation |
ISO EXP |
CYP1A2 protein binds to Caffeine [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine] Caffeine results in decreased activity of CYP1A2 protein CYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolite [Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of Caffeine Caffeine results in increased activity of CYP1A2 protein |
CTD |
PMID:1302044 PMID:9334905 PMID:11145498 PMID:11376689 PMID:11465391 PMID:11907490 PMID:12433797 PMID:12706856 PMID:14586384 PMID:14586387 PMID:15022032 PMID:15199075 PMID:15286053 PMID:15327588 PMID:15619608 PMID:15659567 PMID:15822860 PMID:15856409 PMID:15980104 PMID:16934051 PMID:18420780 PMID:19215233 PMID:20716633 PMID:24211539 PMID:26599973 PMID:28843594 PMID:31132250 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
Caffeine results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp21a1 |
cytochrome P450, family 21, subfamily a, polypeptide 1 |
increases expression decreases expression |
EXP |
Caffeine results in increased expression of CYP21A1 mRNA Caffeine results in decreased expression of CYP21A1 mRNA |
CTD |
PMID:25868845 PMID:30528684 |
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NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
affects metabolic processing |
ISO |
CYP2D6 protein affects the metabolism of Caffeine |
CTD |
PMID:15199075 |
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NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
affects metabolic processing |
ISO |
CYP2E1 protein affects the metabolism of Caffeine |
CTD |
PMID:1302044 PMID:14586387 |
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NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
decreases activity |
ISO |
Caffeine results in decreased activity of CYP3A4 protein |
CTD |
PMID:24211539 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Cyp4b1 |
cytochrome P450, family 4, subfamily b, polypeptide 1 |
increases expression |
ISO |
Caffeine results in increased expression of CYP4B1 mRNA |
CTD |
PMID:18444173 |
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NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of CYP7B1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
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G |
Dad1 |
defender against cell death 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of DAD1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095
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G |
Dcaf11 |
DDB1 and CUL4 associated factor 11 |
decreases expression |
EXP |
Caffeine results in decreased expression of DCAF11 mRNA |
CTD |
PMID:20864626 |
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NCBI chr15:34,233,840...34,244,512
Ensembl chr15:34,234,193...34,244,504
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G |
Dct |
dopachrome tautomerase |
increases expression |
ISO |
Caffeine results in increased expression of DCT mRNA |
CTD |
PMID:18444173 |
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NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
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G |
Dcxr |
dicarbonyl and L-xylulose reductase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DCXR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DCXR mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
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G |
Ddhd1 |
DDHD domain containing 1 |
increases expression |
EXP |
Caffeine results in increased expression of DDHD1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191
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G |
Ddx31 |
DEAD-box helicase 31 |
decreases expression |
EXP |
Caffeine results in decreased expression of DDX31 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 3:7,422,871...7,488,299
Ensembl chr 3:7,422,820...7,488,617
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G |
Ddx39a |
DExD-box helicase 39A |
decreases expression |
ISO |
Caffeine results in decreased expression of DDX39A protein |
CTD |
PMID:31195006 |
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NCBI chr19:24,846,530...24,854,886
Ensembl chr19:24,846,938...24,854,953
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression |
EXP |
Caffeine results in decreased expression of DHCR24 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
decreases expression |
EXP |
Caffeine results in decreased expression of DHCR7 mRNA |
CTD |
PMID:25868845 |
|
NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
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G |
Dhodh |
dihydroorotate dehydrogenase (quinone) |
increases expression |
EXP |
Caffeine results in increased expression of DHODH protein |
CTD |
PMID:6149265 |
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NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012
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G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of DNAJB9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
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G |
Dnajc12 |
DnaJ heat shock protein family (Hsp40) member C12 |
increases expression |
ISO |
Caffeine results in increased expression of DNAJC12 protein |
CTD |
PMID:31195006 |
|
NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016
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G |
Dnmt1 |
DNA methyltransferase 1 |
increases expression |
EXP |
Caffeine results in increased expression of DNMT1 mRNA |
CTD |
PMID:24717552 |
|
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
increases expression |
EXP |
Caffeine results in increased expression of DNMT3A mRNA |
CTD |
PMID:24717552 |
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NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
increases expression |
EXP |
Caffeine results in increased expression of DNMT3B mRNA |
CTD |
PMID:25868845 PMID:30423288 |
|
NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
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G |
Dpp4 |
dipeptidylpeptidase 4 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
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G |
Drd2 |
dopamine receptor D2 |
affects response to substance increases response to substance multiple interactions |
ISO EXP |
DRD2 polymorphism affects the susceptibility to Caffeine DRD2 protein results in increased susceptibility to Caffeine Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]] |
CTD |
PMID:11172060 PMID:16889759 PMID:18305461 |
|
NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
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G |
Dtx4 |
deltex E3 ubiquitin ligase 4 |
decreases expression |
EXP |
Caffeine results in decreased expression of DTX4 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866
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G |
Dusp8 |
dual specificity phosphatase 8 |
increases expression |
EXP |
Caffeine results in increased expression of DUSP8 mRNA |
CTD |
PMID:9813294 |
|
NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA] |
CTD |
PMID:22403396 |
|
NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
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G |
Ebp |
EBP, cholestenol delta-isomerase |
increases expression |
EXP |
Caffeine results in increased expression of EBP mRNA |
CTD |
PMID:25868845 |
|
NCBI chr X:15,049,394...15,055,782
Ensembl chr X:15,049,462...15,055,781
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G |
Ebpl |
EBP like |
decreases expression |
EXP |
Caffeine results in decreased expression of EBPL mRNA |
CTD |
PMID:20864626 |
|
NCBI chr15:41,668,119...41,691,518
Ensembl chr15:41,668,119...41,691,518
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G |
Eci1 |
enoyl-CoA delta isomerase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of ECI1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
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G |
Ecm1 |
extracellular matrix protein 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ECM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699
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G |
Edn1 |
endothelin 1 |
increases activity |
EXP |
Caffeine results in increased activity of EDN1 protein |
CTD |
PMID:1860718 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Eef1a1 |
eukaryotic translation elongation factor 1 alpha 1 |
multiple interactions increases expression |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF1A1 mRNA] Caffeine results in increased expression of EEF1A1 protein |
CTD |
PMID:20230807 PMID:31195006 |
|
NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
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G |
Eef1d |
eukaryotic translation elongation factor 1 delta |
decreases expression |
ISO |
Caffeine results in decreased expression of EEF1D protein |
CTD |
PMID:31195006 |
|
NCBI chr 7:116,928,264...116,942,981
Ensembl chr 7:116,928,265...116,936,674
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G |
Eef1g |
eukaryotic translation elongation factor 1 gamma |
increases expression |
ISO |
Caffeine results in increased expression of EEF1G protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
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G |
Efna1 |
ephrin A1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
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G |
Efnb3 |
ephrin B3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNB3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:56,161,431...56,168,819
Ensembl chr10:56,161,432...56,167,426
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G |
Egr1 |
early growth response 1 |
increases expression decreases expression multiple interactions |
ISO EXP |
Caffeine results in increased expression of EGR1 mRNA Caffeine results in decreased expression of EGR1 mRNA [Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA] [Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA |
CTD |
PMID:10971643 PMID:16771831 |
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NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
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G |
Ehbp1 |
EH domain binding protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of EHBP1 protein |
CTD |
PMID:31195006 |
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NCBI chr14:106,871,426...107,160,224
Ensembl chr14:106,871,430...107,160,334
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G |
Ehd1 |
EH-domain containing 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of EHD1 protein |
CTD |
PMID:31195006 |
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NCBI chr 1:221,644,867...221,667,242
Ensembl chr 1:221,644,867...221,667,239
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G |
Ehd2 |
EH-domain containing 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of EHD2 protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:77,847,599...77,865,870
Ensembl chr 1:77,847,600...77,865,870
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
increases expression |
ISO |
Caffeine results in increased expression of EIF1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
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G |
Eif3b |
eukaryotic translation initiation factor 3, subunit B |
decreases expression |
ISO |
Caffeine results in decreased expression of EIF3B protein |
CTD |
PMID:31195006 |
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NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases expression increases expression |
ISO EXP |
Caffeine results in decreased expression of EIF4EBP1 protein modified form Caffeine results in increased expression of EIF4EBP1 protein |
CTD |
PMID:21081844 |
|
NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
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G |
Eif5 |
eukaryotic translation initiation factor 5 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EIF5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
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G |
Ell |
elongation factor for RNA polymerase II |
decreases expression |
EXP |
Caffeine results in decreased expression of ELL mRNA |
CTD |
PMID:20864626 |
|
NCBI chr16:20,594,129...20,641,441
Ensembl chr16:20,594,072...20,641,908
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G |
Emc6 |
ER membrane protein complex subunit 6 |
decreases expression |
EXP |
Caffeine results in decreased expression of EMC6 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
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G |
Endod1 |
endonuclease domain containing 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of ENDOD1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 8:12,898,430...12,928,156
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G |
Eno1 |
enolase 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
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G |
Eppk1 |
epiplakin 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of EPPK1 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:117,163,383...117,173,741
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
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G |
Erp44 |
endoplasmic reticulum protein 44 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERP44 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901
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G |
Esyt2 |
extended synaptotagmin 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of ESYT2 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 6:144,156,021...144,248,374
Ensembl chr 6:144,156,175...144,245,545
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G |
Etv3 |
ETS variant transcription factor 3 |
increases expression |
ISO |
Caffeine results in increased expression of ETV3 protein |
CTD |
PMID:31195006 |
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NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592
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G |
Eya1 |
EYA transcriptional coactivator and phosphatase 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of EYA1 mRNA |
CTD |
PMID:31711903 |
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NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
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G |
Ezr |
ezrin |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
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G |
Fabp4 |
fatty acid binding protein 4 |
decreases expression |
ISO EXP |
Caffeine results in decreased expression of FABP4 mRNA |
CTD |
PMID:23727198 |
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NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
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G |
Farsa |
phenylalanyl-tRNA synthetase subunit alpha |
increases expression |
ISO |
Caffeine results in increased expression of FARSA protein |
CTD |
PMID:31195006 |
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NCBI chr19:25,969,255...25,978,777
Ensembl chr19:25,969,255...25,978,776
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G |
Fas |
Fas cell surface death receptor |
decreases expression |
EXP |
Caffeine results in decreased expression of FAS mRNA |
CTD |
PMID:29343424 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Fasn |
fatty acid synthase |
multiple interactions increases expression |
ISO EXP |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA Caffeine results in increased expression of FASN mRNA; Caffeine results in increased expression of FASN protein |
CTD |
PMID:28843594 PMID:30776459 |
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NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fastkd3 |
FAST kinase domains 3 |
decreases expression |
EXP |
Caffeine results in decreased expression of FASTKD3 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 1:37,734,400...37,742,932
Ensembl chr 1:37,734,403...37,742,932
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G |
Fau |
FAU, ubiquitin like and ribosomal protein S30 fusion |
increases expression |
ISO |
Caffeine results in increased expression of FAU protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:221,420,312...221,421,827
Ensembl chr 1:221,420,271...221,421,842 Ensembl chr 6:221,420,271...221,421,842
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G |
Fbln2 |
fibulin 2 |
increases expression |
EXP |
Caffeine results in increased expression of FBLN2 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121
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G |
Fbrs |
fibrosin |
increases expression |
EXP |
Caffeine results in increased expression of FBRS mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 1:198,925,265...198,938,939
Ensembl chr 1:198,932,870...198,937,750
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G |
Fbxl12 |
F-box and leucine-rich repeat protein 12 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of FBXL12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 8:21,656,636...21,662,755
Ensembl chr 8:21,656,639...21,661,259
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G |
Fbxl19 |
F-box and leucine-rich repeat protein 19 |
decreases expression |
ISO |
Caffeine results in decreased expression of FBXL19 protein |
CTD |
PMID:31195006 |
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NCBI chr 1:199,196,126...199,217,147
Ensembl chr 1:199,196,059...199,216,391
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G |
Fcsk |
fucose kinase |
increases expression |
EXP |
Caffeine results in increased expression of FCSK mRNA |
CTD |
PMID:20864626 |
|
NCBI chr19:43,338,146...43,357,826
Ensembl chr19:43,338,166...43,357,822
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
decreases expression increases expression |
EXP |
Caffeine results in decreased expression of FDFT1 mRNA Caffeine results in increased expression of FDFT1 mRNA |
CTD |
PMID:20864626 PMID:25868845 |
|
NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
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G |
Fdx1 |
ferredoxin 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of FDX1 mRNA |
CTD |
PMID:20864626 PMID:25868845 |
|
NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233
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G |
Fhl1 |
four and a half LIM domains 1 |
increases expression |
EXP |
Caffeine results in increased expression of FHL1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr X:159,112,516...159,172,528
Ensembl chr X:159,112,880...159,172,524
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G |
Filip1l |
filamin A interacting protein 1-like |
increases expression |
EXP |
Caffeine results in increased expression of FILIP1L mRNA |
CTD |
PMID:20864626 |
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NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
ISO |
Caffeine results in increased expression of FOS mRNA [Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA] |
CTD |
PMID:10971643 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Fyn |
FYN proto-oncogene, Src family tyrosine kinase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
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G |
Gale |
UDP-galactose-4-epimerase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GALE mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GALE mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955
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G |
Ganab |
glucosidase II alpha subunit |
decreases expression |
ISO |
Caffeine results in decreased expression of GANAB protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:225,096,558...225,116,384
Ensembl chr 1:225,096,598...225,116,378
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G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
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G |
Gast |
gastrin |
increases secretion |
EXP |
Caffeine results in increased secretion of GAST protein |
CTD |
PMID:19208342 |
|
NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA |
CTD |
PMID:28843594 |
|
NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gdf10 |
growth differentiation factor 10 |
decreases expression |
EXP |
Caffeine results in decreased expression of GDF10 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr16:10,250,508...10,262,383
Ensembl chr16:10,250,404...10,263,150
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO EXP |
Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein] Caffeine inhibits the reaction [aluminum chloride results in increased expression of GFAP protein] |
CTD |
PMID:19882200 PMID:26339337 |
|
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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G |
Gh1 |
growth hormone 1 |
multiple interactions |
ISO |
GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] |
CTD |
PMID:11907490 |
|
NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
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G |
Ghitm |
growth hormone inducible transmembrane protein |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GHITM mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr16:14,370,269...14,382,647
Ensembl chr16:14,371,531...14,382,641
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G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of GJA1 mRNA |
CTD |
PMID:28087314 |
|
NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
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G |
Glrx |
glutaredoxin |
decreases expression |
ISO |
Caffeine results in decreased expression of GLRX mRNA |
CTD |
PMID:11793227 |
|
NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
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G |
Glt8d1 |
glycosyltransferase 8 domain containing 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of GLT8D1 mRNA |
CTD |
PMID:11793227 |
|
NCBI chr16:7,082,450...7,097,405
Ensembl chr16:7,082,450...7,097,401
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G |
Glud1 |
glutamate dehydrogenase 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of GLUD1 mRNA |
CTD |
PMID:11793227 |
|
NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
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G |
Gmfb |
glia maturation factor, beta |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
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G |
Gnai1 |
G protein subunit alpha i1 |
decreases expression increases expression |
EXP |
Caffeine results in decreased expression of GNAI1 protein Caffeine results in increased expression of GNAI1 mRNA |
CTD |
PMID:15708489 |
|
NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
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G |
Gnai2 |
G protein subunit alpha i2 |
decreases expression |
EXP |
Caffeine results in decreased expression of GNAI2 protein |
CTD |
PMID:15708489 |
|
NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
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G |
Gnal |
G protein subunit alpha L |
increases response to substance |
ISO |
GNAL protein results in increased susceptibility to Caffeine |
CTD |
PMID:11404425 |
|
NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
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G |
Gnaq |
G protein subunit alpha q |
decreases expression |
EXP |
Caffeine results in decreased expression of GNAQ protein |
CTD |
PMID:15998294 |
|
NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
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G |
Gnas |
GNAS complex locus |
decreases expression |
EXP |
Caffeine results in decreased expression of GNAS protein |
CTD |
PMID:15708489 |
|
NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483 Ensembl chr 3:172,374,957...172,428,483
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G |
Golt1b |
golgi transport 1B |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:176,606,669...176,617,884
Ensembl chr 4:176,606,649...176,619,710
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G |
Gosr1 |
golgi SNAP receptor complex member 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of GOSR1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr10:63,405,526...63,442,257
Ensembl chr10:63,405,586...63,442,250
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of GOT2 protein |
CTD |
PMID:31195006 |
|
NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
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G |
Gpc3 |
glypican 3 |
affects expression |
EXP |
Caffeine affects the expression of GPC3 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr X:139,579,268...139,947,093
Ensembl chr X:139,579,268...139,916,883
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G |
Gpi |
glucose-6-phosphate isomerase |
decreases expression |
ISO |
Caffeine results in decreased expression of GPI protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases activity |
EXP |
Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]; fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]] Caffeine results in increased activity of GPT protein |
CTD |
PMID:11394713 PMID:30776459 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
Caffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA] |
CTD |
PMID:31756439 |
|
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
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G |
Gpx3 |
glutathione peroxidase 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
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G |
Gpx4 |
glutathione peroxidase 4 |
multiple interactions |
ISO |
[Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA |
CTD |
PMID:31756439 |
|
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
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G |
Grid2 |
glutamate ionotropic receptor delta type subunit 2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:94,068,112...95,476,864
Ensembl chr 4:94,696,965...95,442,778
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G |
Grm1 |
glutamate metabotropic receptor 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of GRM1 protein |
CTD |
PMID:15998294 |
|
NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
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G |
Grpr |
gastrin releasing peptide receptor |
decreases expression |
EXP |
Caffeine results in decreased expression of GRPR mRNA |
CTD |
PMID:20864626 |
|
NCBI chr X:32,746,259...32,786,266
Ensembl chr X:32,745,873...32,786,359
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G |
Grwd1 |
glutamate-rich WD repeat containing 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of GRWD1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 1:101,813,356...101,819,058
Ensembl chr 1:101,813,684...101,819,478
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
increases expression |
EXP |
Caffeine results in increased expression of GSK3A mRNA |
CTD |
PMID:25868845 |
|
NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation decreases phosphorylation multiple interactions |
ISO |
Caffeine results in increased phosphorylation of GSK3B protein Caffeine results in decreased phosphorylation of GSK3B protein N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:15126379 PMID:21229324 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA |
CTD |
PMID:28843594 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of GSTO1 mRNA |
CTD |
PMID:11793227 |
|
NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
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G |
H1f0 |
H1.0 linker histone |
decreases expression |
ISO |
Caffeine results in decreased expression of H1F0 protein |
CTD |
PMID:31195006 |
|
NCBI chr 7:120,260,776...120,262,636
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G |
H1f4 |
H1.4 linker histone, cluster member |
increases expression |
ISO |
Caffeine results in increased expression of H1-4 protein |
CTD |
PMID:31195006 |
|
NCBI chr17:43,734,461...43,735,120
Ensembl chr17:43,734,461...43,735,120
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G |
H1f5 |
H1.5 linker histone, cluster member |
increases expression |
ISO |
Caffeine results in increased expression of H1-5 protein |
CTD |
PMID:31195006 |
|
NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
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G |
H1f6 |
H1.6 linker histone, cluster member |
increases expression |
ISO |
Caffeine results in increased expression of H1-6 protein |
CTD |
PMID:31195006 |
|
NCBI chr17:43,675,190...43,675,934
Ensembl chr17:43,675,190...43,675,934
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G |
H2ax |
H2A.X variant histone |
multiple interactions |
ISO EXP |
Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein |
CTD |
PMID:15537744 PMID:15975956 PMID:16777994 PMID:20888899 PMID:24069304 PMID:26231820 |
|
NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Hacd1 |
3-hydroxyacyl-CoA dehydratase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of HACD1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr17:81,173,238...81,196,012
Ensembl chr17:81,173,713...81,187,739
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G |
Hba-a1 |
hemoglobin alpha, adult chain 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649
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G |
Hdac1 |
histone deacetylase 1 |
increases expression |
EXP |
Caffeine results in increased expression of HDAC1 mRNA |
CTD |
PMID:24717552 |
|
NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
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G |
Hdac2 |
histone deacetylase 2 |
increases expression |
EXP |
Caffeine results in increased expression of HDAC2 mRNA |
CTD |
PMID:24717552 |
|
NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
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G |
Hdac7 |
histone deacetylase 7 |
increases expression |
EXP |
Caffeine results in increased expression of HDAC7 mRNA; Caffeine results in increased expression of HDAC7 protein |
CTD |
PMID:31306741 |
|
NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
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G |
Hdlbp |
high density lipoprotein binding protein |
decreases expression |
EXP |
Caffeine results in decreased expression of HDLBP mRNA |
CTD |
PMID:25868845 |
|
NCBI chr 9:100,554,574...100,624,707
Ensembl chr 9:100,554,563...100,624,638
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G |
Heca |
hdc homolog, cell cycle regulator |
increases expression |
EXP |
Caffeine results in increased expression of HECA mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 1:13,036,909...13,050,644
Ensembl chr 1:13,036,909...13,050,644
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G |
Hells |
helicase, lymphoid specific |
multiple interactions increases expression |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA] Caffeine results in increased expression of HELLS protein |
CTD |
PMID:20025956 PMID:20230807 |
|
NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183 Ensembl chr 1:257,766,691...257,949,183
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G |
Hhipl2 |
HHIP like 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of HHIPL2 protein |
CTD |
PMID:31195006 |
|
NCBI chr13:101,814,574...101,835,144
Ensembl chr13:101,814,574...101,834,584
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
[Caffeine co-treated with bisphenol A] results in decreased expression of HIF1A mRNA |
CTD |
PMID:31756439 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hint1 |
histidine triad nucleotide binding protein 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975
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G |
Hist1h4b |
histone cluster 1 H4 family member B |
increases expression |
ISO |
Caffeine results in increased expression of H4C9 protein |
CTD |
PMID:31195006 |
|
NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583
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G |
Hmga1 |
high mobility group AT-hook 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of HMGA1 protein |
CTD |
PMID:31195006 |
|
NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
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G |
Hmga2 |
high mobility group AT-hook 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of HMGA2 protein |
CTD |
PMID:31195006 |
|
NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
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G |
Hmgb1 |
high mobility group box 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of HMGB1 protein |
CTD |
PMID:31195006 |
|
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions increases expression |
EXP ISO |
[Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA; Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA] Caffeine results in increased expression of HMGCR mRNA; Caffeine results in increased expression of HMGCR protein 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA] |
CTD |
PMID:29800656 PMID:29958987 PMID:30825513 |
|
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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G |
Hmgcs1 |
3-hydroxy-3-methylglutaryl-CoA synthase 1 |
decreases expression increases expression multiple interactions |
EXP ISO |
Caffeine results in decreased expression of HMGCS1 mRNA Caffeine results in increased expression of HMGCS1 mRNA 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA] |
CTD |
PMID:20864626 PMID:25868845 PMID:30825513 |
|
NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
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G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
decreases expression |
ISO |
Caffeine results in decreased expression of HNRNPA1 protein |
CTD |
PMID:31195006 |
|
NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
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G |
Hnrnpc |
heterogeneous nuclear ribonucleoprotein C |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HNRNPC mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HNRNPC mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
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G |
Hnrnpdl |
heterogeneous nuclear ribonucleoprotein D-like |
decreases expression |
ISO |
Caffeine results in decreased expression of HNRNPDL protein |
CTD |
PMID:31195006 |
|
NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669
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G |
Hnrnpf |
heterogeneous nuclear ribonucleoprotein F |
decreases expression |
ISO |
Caffeine results in decreased expression of HNRNPF protein |
CTD |
PMID:31195006 |
|
NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895
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G |
Hnrnph1 |
heterogeneous nuclear ribonucleoprotein H1 |
decreases expression |
ISO |
Caffeine results in decreased expression of HNRNPH1 protein |
CTD |
PMID:31195006 |
|
NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
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G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
decreases expression increases expression |
EXP ISO |
Caffeine results in decreased expression of HNRNPK mRNA Caffeine results in increased expression of HNRNPK protein |
CTD |
PMID:25868845 PMID:31195006 |
|
NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
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G |
Homer1 |
homer scaffold protein 1 |
multiple interactions |
EXP |
HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] |
CTD |
PMID:12887973 |
|
NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
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G |
Hoxb7 |
homeo box B7 |
increases expression |
ISO |
Caffeine results in increased expression of HOXB7 mRNA |
CTD |
PMID:31711903 |
|
NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637
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G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
increases expression |
EXP |
Caffeine results in increased expression of HPRT1 protein |
CTD |
PMID:6149265 |
|
NCBI chr X:158,196,640...158,228,815
Ensembl chr X:158,197,149...158,228,749 Ensembl chr X:158,197,149...158,228,749
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
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G |
Hsd11b1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases expression |
EXP |
Caffeine results in increased expression of HSD11B1 mRNA |
CTD |
PMID:22583948 PMID:30423288 PMID:30528684 |
|
NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
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G |
Hsd11b2 |
hydroxysteroid 11-beta dehydrogenase 2 |
decreases expression multiple interactions |
EXP ISO |
Caffeine results in decreased expression of HSD11B2 mRNA ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA] |
CTD |
PMID:22583948 PMID:22701600 PMID:30423288 PMID:30528684 |
|
NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
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G |
Hsd17b7 |
hydroxysteroid (17-beta) dehydrogenase 7 |
decreases expression |
EXP |
Caffeine results in decreased expression of HSD17B7 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
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G |
Hsd3b1 |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 |
increases expression decreases expression |
EXP |
Caffeine results in increased expression of HSD3B1 mRNA Caffeine results in decreased expression of HSD3B1 mRNA |
CTD |
PMID:25868845 PMID:30528684 |
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Hsp90aa1 |
heat shock protein 90 alpha family class A member 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775 Ensembl chr 6:135,107,271...135,112,775
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Hsp90b1 |
heat shock protein 90 beta family member 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of HSP90B1 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
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Hspa4 |
heat shock protein family A (Hsp70) member 4 |
increases expression |
ISO |
Caffeine results in increased expression of HSPA4 protein |
CTD |
PMID:31195006 |
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NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
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Hspa9 |
heat shock protein family A (Hsp70) member 9 |
decreases expression |
ISO |
Caffeine results in decreased expression of HSPA9 protein |
CTD |
PMID:31195006 |
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NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
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Hspb1 |
heat shock protein family B (small) member 1 |
increases expression decreases expression |
EXP ISO |
Caffeine results in increased expression of HSPB1 mRNA Caffeine results in decreased expression of HSPB1 protein |
CTD |
PMID:20864626 PMID:31195006 |
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NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
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Hspb6 |
heat shock protein family B (small) member 6 |
increases expression |
EXP |
Caffeine results in increased expression of HSPB6 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256
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Hspe1 |
heat shock protein family E (Hsp10) member 1 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599
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Ibsp |
integrin-binding sialoprotein |
decreases expression |
EXP |
Caffeine results in decreased expression of IBSP mRNA |
CTD |
PMID:31874197 |
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NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
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Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of ICAM1 mRNA |
CTD |
PMID:28089782 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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Id3 |
inhibitor of DNA binding 3, HLH protein |
increases expression |
EXP |
Caffeine results in increased expression of ID3 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
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Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of IDI1 mRNA |
CTD |
PMID:20864626 PMID:25868845 |
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NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
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Igf1 |
insulin-like growth factor 1 |
decreases secretion multiple interactions affects expression decreases activity decreases expression |
ISO EXP |
Caffeine results in decreased secretion of IGF1 protein [Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNA Caffeine affects the expression of IGF1 protein Caffeine results in decreased activity of IGF1 protein Caffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 protein |
CTD |
PMID:1995187 PMID:22583948 PMID:24239806 PMID:29343424 PMID:29966748 PMID:30528684 PMID:31756439 |
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NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
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Igf1r |
insulin-like growth factor 1 receptor |
decreases expression affects expression |
EXP |
Caffeine results in decreased expression of IGF1R mRNA; Caffeine results in decreased expression of IGF1R protein Caffeine affects the expression of IGF1R mRNA |
CTD |
PMID:22583948 PMID:29343424 PMID:29966748 PMID:30528684 |
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NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
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Igfbp1 |
insulin-like growth factor binding protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of IGFBP1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
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Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
increases expression |
EXP |
Caffeine results in increased expression of IKBKB mRNA |
CTD |
PMID:20864626 |
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NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
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Il10 |
interleukin 10 |
increases expression |
ISO |
Caffeine results in increased expression of IL10 mRNA |
CTD |
PMID:28089782 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il10rb |
interleukin 10 receptor subunit beta |
increases expression |
EXP |
Caffeine results in increased expression of IL10RB mRNA |
CTD |
PMID:20864626 |
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NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
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Il12a |
interleukin 12A |
decreases expression |
ISO |
Caffeine results in decreased expression of IL12A mRNA |
CTD |
PMID:28089782 |
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NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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Il12b |
interleukin 12B |
multiple interactions |
ISO |
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] |
CTD |
PMID:26852703 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il1b |
interleukin 1 beta |
decreases expression increases expression |
ISO EXP |
Caffeine results in decreased expression of IL1B mRNA Caffeine results in increased expression of IL1B mRNA |
CTD |
PMID:28089782 PMID:29055810 PMID:30776459 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il1rl1 |
interleukin 1 receptor-like 1 |
increases expression |
ISO |
Caffeine results in increased expression of IL1RL1 protein |
CTD |
PMID:20025956 |
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NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
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Il3 |
interleukin 3 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA] |
CTD |
PMID:26852703 |
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NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
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Il4r |
interleukin 4 receptor |
increases expression multiple interactions |
EXP ISO |
Caffeine results in increased expression of IL4RA mRNA [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IL4RA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA] |
CTD |
PMID:20230807 PMID:20864626 |
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NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
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Il5 |
interleukin 5 |
increases expression |
ISO |
Caffeine results in increased expression of IL5 mRNA |
CTD |
PMID:28089782 |
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NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
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Il6 |
interleukin 6 |
decreases expression increases expression multiple interactions |
EXP ISO |
Caffeine results in decreased expression of IL6 mRNA Caffeine results in increased expression of IL6 mRNA Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] |
CTD |
PMID:23727198 PMID:26852703 PMID:29055810 PMID:30776459 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ilf3 |
interleukin enhancer binding factor 3 |
increases expression |
ISO |
Caffeine results in increased expression of ILF3 protein |
CTD |
PMID:31195006 |
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NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885
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Impdh2 |
inosine monophosphate dehydrogenase 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of IMPDH2 protein |
CTD |
PMID:31195006 |
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NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610
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Ino80c |
INO80 complex subunit C |
decreases expression |
EXP |
Caffeine results in decreased expression of INO80C mRNA |
CTD |
PMID:20864626 |
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NCBI chr18:15,995,005...16,009,639
Ensembl chr18:15,995,000...16,009,710
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Ins2 |
insulin 2 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:21081844 |
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NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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Insig1 |
insulin induced gene 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of INSIG1 mRNA |
CTD |
PMID:20864626 PMID:25868845 |
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NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
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Insr |
insulin receptor |
decreases expression |
EXP |
Caffeine results in decreased expression of INSR mRNA |
CTD |
PMID:22583948 |
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NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
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G |
Irak1 |
interleukin-1 receptor-associated kinase 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr X:156,716,469...156,726,367
Ensembl chr X:156,716,604...156,725,977
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Irx3 |
iroquois homeobox 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:15,838,714...15,842,135
Ensembl chr19:15,838,714...15,840,990
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Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGAM protein] |
CTD |
PMID:19882200 |
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NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
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G |
Itm2b |
integral membrane protein 2B |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713
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Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of ITPR1 mRNA |
CTD |
PMID:18444173 |
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NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases phosphorylation increases expression |
ISO |
Caffeine results in decreased phosphorylation of JUN protein Caffeine results in increased expression of JUN protein |
CTD |
PMID:17145898 PMID:20025956 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Kctd14 |
potassium channel tetramerization domain containing 14 |
decreases expression |
EXP |
Caffeine results in decreased expression of KCTD14 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 1:162,418,389...162,424,322
Ensembl chr 1:162,419,262...162,424,825
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G |
Khsrp |
KH-type splicing regulatory protein |
increases expression |
ISO |
Caffeine results in increased expression of KHSRP protein |
CTD |
PMID:31195006 |
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NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924
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Kidins220 |
kinase D-interacting substrate 220 |
increases expression |
EXP |
Caffeine results in increased expression of KIDINS220 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 6:44,225,142...44,322,938
Ensembl chr 6:44,225,233...44,322,938
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G |
Kif3b |
kinesin family member 3B |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KIF3B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293
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Klf4 |
Kruppel like factor 4 |
multiple interactions decreases expression |
ISO EXP |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA] Caffeine results in decreased expression of KLF4 mRNA; Caffeine results in decreased expression of KLF4 protein |
CTD |
PMID:20230807 PMID:31306741 |
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NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
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Krt1 |
keratin 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of KRT1 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
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Krt18 |
keratin 18 |
decreases expression |
ISO |
Caffeine results in decreased expression of KRT18 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
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Krt36 |
keratin 36 |
decreases expression |
ISO |
Caffeine results in decreased expression of KRT36 protein |
CTD |
PMID:31195006 |
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NCBI chr10:88,016,602...88,019,967
Ensembl chr10:88,016,602...88,019,967
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Krt84 |
keratin 84 |
decreases expression |
ISO |
Caffeine results in decreased expression of KRT84 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:143,180,212...143,187,684
Ensembl chr 7:143,179,835...143,187,648
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Lamb1 |
laminin subunit beta 1 |
increases expression |
ISO |
Caffeine results in increased expression of LAMB1 protein |
CTD |
PMID:31195006 |
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NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
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Ldha |
lactate dehydrogenase A |
decreases expression |
ISO |
Caffeine results in decreased expression of LDHA mRNA |
CTD |
PMID:11793227 |
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NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
EXP |
[Caffeine co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; Caffeine promotes the reaction [Dietary Fats results in decreased expression of LDLR mRNA] |
CTD |
PMID:29800656 |
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NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
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Lep |
leptin |
decreases expression multiple interactions |
ISO EXP |
Caffeine results in decreased expression of LEP mRNA Caffeine results in decreased expression of LEP mRNA; Caffeine results in decreased expression of LEP protein 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA] |
CTD |
PMID:23727198 PMID:26367767 |
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NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lepr |
leptin receptor |
increases expression decreases expression |
EXP |
Caffeine results in increased expression of LEPR mRNA Caffeine results in decreased expression of LEPR mRNA |
CTD |
PMID:22583948 PMID:26367767 |
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NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
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Lmnb1 |
lamin B1 |
decreases expression |
ISO |
Caffeine results in decreased expression of LMNB1 protein |
CTD |
PMID:31195006 |
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NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
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LOC100361854 |
ribosomal protein S26-like |
increases expression |
ISO |
Caffeine results in increased expression of RPS26 protein |
CTD |
PMID:31195006 |
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NCBI chr X:115,495,660...115,496,062
Ensembl chr X:115,495,698...115,496,045
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G |
Lpar4 |
lysophosphatidic acid receptor 4 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr X:78,042,859...78,056,347
Ensembl chr X:78,042,859...78,056,347
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Lpl |
lipoprotein lipase |
decreases expression multiple interactions |
EXP ISO |
Caffeine results in decreased expression of LPL mRNA [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA |
CTD |
PMID:23727198 PMID:28843594 |
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NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
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G |
Lss |
lanosterol synthase |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA |
CTD |
PMID:28843594 |
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NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
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G |
Lysmd2 |
LysM domain containing 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of LYSMD2 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 8:82,560,363...82,576,662
Ensembl chr 8:82,560,761...82,577,019
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Mael |
maelstrom spermatogenic transposon silencer |
decreases expression |
ISO |
Caffeine results in decreased expression of MAEL protein |
CTD |
PMID:31195006 |
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NCBI chr13:84,412,569...84,452,140
Ensembl chr13:84,383,670...84,452,181
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G |
Maoa |
monoamine oxidase A |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] |
CTD |
PMID:20230807 |
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NCBI chr X:6,554,698...6,620,722
Ensembl chr X:6,554,698...6,620,722
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
increases cleavage multiple interactions |
ISO |
Caffeine results in increased cleavage of MAP1LC3B protein 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein] 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein] |
CTD |
PMID:30555576 |
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NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
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G |
Map2k7 |
mitogen activated protein kinase kinase 7 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAP2K7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
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G |
Map3k12 |
mitogen activated protein kinase kinase kinase 12 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP3K12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP3K12 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116
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G |
Mapk1 |
mitogen activated protein kinase 1 |
increases expression multiple interactions decreases phosphorylation |
ISO |
Caffeine results in increased expression of MAPK1 protein modified form Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] Caffeine results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:17145898 PMID:21081844 PMID:22974838 |
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NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk15 |
mitogen-activated protein kinase 15 |
increases expression |
EXP |
Caffeine results in increased expression of MAPK15 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 7:117,041,287...117,061,799
Ensembl chr 7:117,055,395...117,061,047
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G |
Mapk3 |
mitogen activated protein kinase 3 |
increases expression multiple interactions decreases phosphorylation |
ISO |
Caffeine results in increased expression of MAPK3 protein modified form Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] Caffeine results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:17145898 PMID:21081844 PMID:22974838 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Marchf11 |
membrane associated ring-CH-type finger 11 |
decreases expression |
EXP |
Caffeine results in decreased expression of MARCHF11 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 2:78,825,053...78,926,402
Ensembl chr 2:78,825,074...78,926,395
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G |
Mc2r |
melanocortin 2 receptor |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MC2R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MC2R mRNA] |
CTD |
PMID:20230807 |
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NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
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G |
Mcm3 |
minichromosome maintenance complex component 3 |
increases expression |
ISO |
Caffeine results in increased expression of MCM3 protein |
CTD |
PMID:20025956 |
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NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
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G |
Mdh2 |
malate dehydrogenase 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of MDH2 protein |
CTD |
PMID:31195006 |
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NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431
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G |
Mef2a |
myocyte enhancer factor 2a |
increases expression multiple interactions |
EXP |
Caffeine results in increased expression of MEF2A mRNA; Caffeine results in increased expression of MEF2A protein Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein] |
CTD |
PMID:25093688 |
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NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
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G |
Mef2c |
myocyte enhancer factor 2C |
multiple interactions increases expression |
EXP |
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein] Caffeine results in increased expression of MEF2C mRNA; Caffeine results in increased expression of MEF2C protein |
CTD |
PMID:25093688 |
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NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
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G |
Mgst1 |
microsomal glutathione S-transferase 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of MGST1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
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G |
Micb |
MHC class I polypeptide-related sequence B |
multiple interactions |
ISO |
Caffeine inhibits the reaction [[Decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein] |
CTD |
PMID:18395517 |
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NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092
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G |
Mill1 |
MHC I like leukocyte 1 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [Resveratrol results in increased expression of MICA protein] |
CTD |
PMID:23445485 |
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NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941
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G |
Mir101a |
microRNA 101a |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA |
CTD |
PMID:28843594 |
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NCBI chr 5:120,168,437...120,168,511
Ensembl chr 5:120,168,433...120,168,515
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G |
Mir122 |
microRNA 122 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA |
CTD |
PMID:28843594 |
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NCBI chr18:60,755,285...60,755,369
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G |
Mir192 |
microRNA 192 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA |
CTD |
PMID:28843594 |
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NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions decreases expression |
EXP |
Caffeine inhibits the reaction [aluminum chloride results in decreased expression of MKI67 protein] Caffeine results in decreased expression of MKI67 protein |
CTD |
PMID:26339337 PMID:30528684 |
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NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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G |
Mlxipl |
MLX interacting protein-like |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA |
CTD |
PMID:28843594 |
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NCBI chr12:24,590,645...24,619,639
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G |
Mmp13 |
matrix metallopeptidase 13 |
increases expression |
EXP |
Caffeine results in increased expression of MMP13 mRNA |
CTD |
PMID:31874197 |
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NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
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G |
Mmp7 |
matrix metallopeptidase 7 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
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G |
Mogat1 |
monoacylglycerol O-acyltransferase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of MOGAT1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 9:84,405,481...84,418,657
Ensembl chr 9:84,405,477...84,418,591
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G |
Mos |
MOS proto-oncogene, serine/threonine kinase |
increases expression |
ISO |
Caffeine results in increased expression of MOS protein |
CTD |
PMID:31195006 |
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NCBI chr 5:16,746,085...16,747,392
Ensembl chr 5:16,746,197...16,747,222
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G |
Mrm3 |
mitochondrial rRNA methyltransferase 3 |
decreases expression |
EXP |
Caffeine results in decreased expression of MRM3 mRNA |
CTD |
PMID:20864626 |
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NCBI chr10:64,398,308...64,406,193
Ensembl chr10:64,398,339...64,405,017
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G |
Mrpl19 |
mitochondrial ribosomal protein L19 |
decreases expression |
EXP |
Caffeine results in decreased expression of MRPL19 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 4:112,703,041...112,707,270
Ensembl chr 4:112,703,041...112,707,270
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G |
Mrpl20 |
mitochondrial ribosomal protein L20 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 5:173,248,245...173,252,775
Ensembl chr 5:173,248,245...173,252,775
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G |
mrpl9 |
mitochondrial ribosomal protein L9 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:195,684,750...195,689,470
Ensembl chr 2:195,684,210...195,689,052
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G |
Mrps5 |
mitochondrial ribosomal protein S5 |
increases expression |
ISO |
Caffeine results in increased expression of MRPS5 protein |
CTD |
PMID:31195006 |
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NCBI chr 3:120,165,953...120,182,536
Ensembl chr 3:120,165,913...120,182,536
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G |
Msh2 |
mutS homolog 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of MSH2 mRNA |
CTD |
PMID:12706856 |
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NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
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G |
Msmo1 |
methylsterol monooxygenase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of MSMO1 mRNA |
CTD |
PMID:20864626 PMID:25868845 |
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NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
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G |
Mt2A |
metallothionein 2A |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
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G |
Mtch1 |
mitochondrial carrier 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTCH1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr20:6,937,341...6,961,165
Ensembl chr20:6,937,347...6,961,162
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G |
Mtf2 |
metal response element binding transcription factor 2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977
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G |
Mthfd2l |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like |
decreases expression |
EXP |
Caffeine results in decreased expression of MTHFD2L mRNA |
CTD |
PMID:20864626 |
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NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases activity |
ISO |
Caffeine results in decreased activity of MTOR protein |
CTD |
PMID:21081844 |
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NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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G |
Mtrr |
5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
decreases expression |
EXP |
Caffeine results in decreased expression of MTRR mRNA |
CTD |
PMID:20864626 |
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NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
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G |
Mutyh |
mutY DNA glycosylase |
increases expression |
EXP |
Caffeine results in increased expression of MUTYH mRNA |
CTD |
PMID:20864626 |
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NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344
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G |
Mvd |
mevalonate diphosphate decarboxylase |
decreases expression |
EXP |
Caffeine results in decreased expression of MVD mRNA |
CTD |
PMID:25868845 |
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NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
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G |
Mvk |
mevalonate kinase |
increases expression |
EXP |
Caffeine results in increased expression of MVK mRNA |
CTD |
PMID:25868845 |
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NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
EXP |
Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA] |
CTD |
PMID:18283038 |
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NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Myh7 |
myosin heavy chain 7 |
increases expression multiple interactions |
EXP |
Caffeine results in increased expression of MYH7 mRNA Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; Cyclosporine inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]] |
CTD |
PMID:25093688 |
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NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
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G |
Myl6b |
myosin light chain 6B |
decreases expression |
ISO |
Caffeine results in decreased expression of MYL6B protein |
CTD |
PMID:31195006 |
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NCBI chr X:43,831,778...43,833,044
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G |
Myof |
myoferlin |
increases expression |
ISO |
Caffeine results in increased expression of MYOF protein |
CTD |
PMID:31195006 |
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NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730
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G |
Nat2 |
N-acetyltransferase 2 |
increases acetylation affects metabolic processing |
ISO |
NAT2 protein results in increased acetylation of Caffeine NAT2 gene polymorphism affects the metabolism of Caffeine; NAT2 protein affects the metabolism of Caffeine |
CTD |
PMID:14586384 PMID:14586387 PMID:14747882 PMID:15199075 PMID:15327588 PMID:15558239 PMID:15980104 PMID:24221535 |
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NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
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G |
Ncl |
nucleolin |
increases expression |
ISO |
Caffeine results in increased expression of NCL protein |
CTD |
PMID:31195006 |
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NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643
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G |
Ndufb5 |
NADH:ubiquinone oxidoreductase subunit B5 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NDUFB5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:119,139,717...119,153,753
Ensembl chr 2:119,139,717...119,153,753
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFS4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFS4 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
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G |
Nefh |
neurofilament heavy chain |
affects expression |
EXP |
Caffeine affects the expression of NEFH mRNA |
CTD |
PMID:22954530 |
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NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
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G |
Neurog2 |
neurogenin 2 |
increases expression |
ISO |
Caffeine results in increased expression of NEUROG2 mRNA |
CTD |
PMID:31711903 |
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NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] |
CTD |
PMID:22974838 |
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NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:26852703 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nisch |
nischarin |
multiple interactions |
EXP |
Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] |
CTD |
PMID:22613216 |
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NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:22974838 PMID:26852703 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
[Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA |
CTD |
PMID:29447158 |
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NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Nphs1 |
NPHS1 adhesion molecule, nephrin |
decreases expression |
EXP |
Caffeine results in decreased expression of NPHS1 mRNA; Caffeine results in decreased expression of NPHS1 protein |
CTD |
PMID:25986755 PMID:31306741 |
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NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
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G |
Nphs2 |
NPHS2 stomatin family member, podocin |
decreases expression |
EXP |
Caffeine results in decreased expression of NPHS2 mRNA |
CTD |
PMID:25986755 PMID:31306741 |
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NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
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G |
Npl |
N-acetylneuraminate pyruvate lyase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr13:70,938,073...70,981,179
Ensembl chr13:70,938,082...70,980,913
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G |
Nppa |
natriuretic peptide A |
multiple interactions increases expression |
EXP |
Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] |
CTD |
PMID:15452191 PMID:25093688 |
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NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
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G |
Nppb |
natriuretic peptide B |
increases expression multiple interactions |
EXP |
Caffeine results in increased expression of NPPB mRNA Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA] |
CTD |
PMID:25093688 |
|
NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA |
CTD |
PMID:28843594 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
increases expression |
EXP |
Caffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 protein |
CTD |
PMID:22583948 PMID:30423288 PMID:30528684 PMID:30776459 PMID:31306741 PMID:32663519 |
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NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
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G |
Nr3c2 |
nuclear receptor subfamily 3, group C, member 2 |
increases expression |
EXP |
Caffeine results in increased expression of NR3C2 mRNA |
CTD |
PMID:22959462 |
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NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
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G |
Nr5a1 |
nuclear receptor subfamily 5, group A, member 1 |
increases methylation decreases expression |
EXP |
Caffeine results in increased methylation of NR5A1 promoter Caffeine results in decreased expression of NR5A1 mRNA; Caffeine results in decreased expression of NR5A1 protein |
CTD |
PMID:24717552 |
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NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
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G |
Nrf1 |
nuclear respiratory factor 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of NRF1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
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G |
Nsf |
N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
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G |
Nt5e |
5' nucleotidase, ecto |
decreases activity multiple interactions |
EXP |
Caffeine results in decreased activity of NT5E protein caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein] |
CTD |
PMID:28465162 |
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NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
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G |
Oat |
ornithine aminotransferase |
increases expression |
ISO |
Caffeine results in increased expression of OAT mRNA |
CTD |
PMID:11793227 |
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NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
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G |
Olig3 |
oligodendrocyte transcription factor 3 |
increases expression |
ISO |
Caffeine results in increased expression of OLIG3 mRNA |
CTD |
PMID:31711903 |
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NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
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G |
Orm1 |
orosomucoid 1 |
increases expression |
ISO |
Caffeine results in increased expression of ORM1 protein |
CTD |
PMID:20025956 |
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NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
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G |
Oxsr1 |
oxidative stress responsive kinase 1 |
increases expression |
EXP |
Caffeine results in increased expression of OXSR1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 8:127,920,349...128,009,951
Ensembl chr 8:127,920,349...128,009,951
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G |
P3h3 |
prolyl 3-hydroxylase 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of P3H3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 4:157,359,331...157,375,186
Ensembl chr 4:157,359,332...157,372,861
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G |
Pak1 |
p21 (RAC1) activated kinase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of PAK1 mRNA |
CTD |
PMID:29343424 |
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NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
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G |
Pak2 |
p21 (RAC1) activated kinase 2 |
multiple interactions increases activity |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA] Caffeine results in increased activity of PAK2 protein |
CTD |
PMID:19325779 PMID:20230807 |
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NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902 Ensembl chr11:72,829,238...72,865,902
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
affects cleavage decreases response to substance multiple interactions increases cleavage |
ISO EXP |
Caffeine affects the cleavage of PARP1 protein PARP1 protein results in decreased susceptibility to Caffeine Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein] [Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 protein Caffeine results in increased cleavage of PARP1 protein |
CTD |
PMID:16522534 PMID:19242509 PMID:19490937 PMID:21229324 PMID:21840268 PMID:22226932 PMID:30377735 |
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NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pax3 |
paired box 3 |
decreases expression |
ISO |
Caffeine results in decreased expression of PAX3 mRNA |
CTD |
PMID:31711903 |
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NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172
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G |
Pcare |
photoreceptor cilium actin regulator |
decreases expression |
ISO |
Caffeine results in decreased expression of PCARE protein |
CTD |
PMID:31195006 |
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NCBI chr 6:23,337,507...23,346,232
Ensembl chr 6:23,337,571...23,346,173
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G |
Pcna |
proliferating cell nuclear antigen |
affects expression |
EXP |
Caffeine affects the expression of PCNA mRNA; Caffeine affects the expression of PCNA protein |
CTD |
PMID:29343424 |
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NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
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G |
Pcsk9 |
proprotein convertase subtilisin/kexin type 9 |
decreases expression |
EXP |
Caffeine results in decreased expression of PCSK9 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
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G |
Pde11a |
phosphodiesterase 11A |
decreases expression |
EXP |
Caffeine results in decreased expression of PDE11A mRNA |
CTD |
PMID:20864626 |
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NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
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G |
Pde5a |
phosphodiesterase 5A |
decreases expression |
EXP |
Caffeine results in decreased expression of PDE5A mRNA |
CTD |
PMID:20864626 |
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NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
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G |
Pdhx |
pyruvate dehydrogenase complex, component X |
decreases expression |
EXP |
Caffeine results in decreased expression of PDHX mRNA |
CTD |
PMID:20864626 |
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NCBI chr 3:92,910,300...92,933,725
Ensembl chr 3:92,909,725...92,969,050
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G |
Pdia6 |
protein disulfide isomerase family A, member 6 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PDIA6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
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G |
Pfdn1 |
prefoldin subunit 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr18:29,233,987...29,290,447
Ensembl chr18:29,233,987...29,290,447
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G |
Pfkm |
phosphofructokinase, muscle |
affects expression |
ISO |
Caffeine affects the expression of PFKM protein |
CTD |
PMID:25486098 |
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NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
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G |
Pgk2 |
phosphoglycerate kinase 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of PGK2 protein |
CTD |
PMID:31195006 |
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NCBI chr 9:24,095,774...24,097,340
Ensembl chr 9:24,095,751...24,097,337
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G |
Pgr |
progesterone receptor |
increases expression |
EXP |
Caffeine results in increased expression of PGR mRNA |
CTD |
PMID:20864626 |
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NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
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G |
Phb |
prohibitin |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878
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G |
Phex |
phosphate regulating endopeptidase homolog, X-linked |
increases expression |
ISO |
Caffeine results in increased expression of PHEX protein |
CTD |
PMID:20025956 |
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NCBI chr X:40,460,047...40,717,982
Ensembl chr X:40,460,047...40,717,982
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G |
Phtf1 |
putative homeodomain transcription factor 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PHTF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 2:206,452,115...206,518,387
Ensembl chr 2:206,454,208...206,493,030
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G |
Pidd1 |
p53-induced death domain protein 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881 Ensembl chr 1:214,419,240...214,423,881
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G |
Pigc |
phosphatidylinositol glycan anchor biosynthesis, class C |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] |
CTD |
PMID:20230807 |
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NCBI chr13:79,886,832...79,889,305
Ensembl chr13:79,886,832...79,889,304
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G |
Pip5k1c |
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 7:11,267,207...11,294,291
Ensembl chr 7:11,267,218...11,294,249
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G |
Pitx2 |
paired-like homeodomain 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of PITX2 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129
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G |
Pkd1 |
polycystin 1, transient receptor potential channel interacting |
multiple interactions affects response to substance |
ISO |
PKD1 protein affects the reaction [Caffeine affects the abundance of Calcium] PKD1 protein affects the susceptibility to Caffeine |
CTD |
PMID:18679710 |
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NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008
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G |
Pla2g12a |
phospholipase A2, group XIIA |
multiple interactions |
ISO |
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA |
CTD |
PMID:28843594 |
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NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
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G |
Plcb1 |
phospholipase C beta 1 |
multiple interactions decreases expression |
EXP |
Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein] Caffeine results in decreased expression of PLCB1 protein |
CTD |
PMID:15998294 |
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NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
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G |
Plec |
plectin |
decreases expression |
ISO |
Caffeine results in decreased expression of PLEC protein |
CTD |
PMID:31195006 |
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NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961
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G |
Plg |
plasminogen |
decreases expression |
EXP |
Caffeine results in decreased expression of PLG mRNA |
CTD |
PMID:25868845 |
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NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
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G |
Plp1 |
proteolipid protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of PLP1 mRNA |
CTD |
PMID:18444173 |
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NCBI chr X:107,494,326...107,511,355
Ensembl chr X:107,496,072...107,511,348
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G |
Pls1 |
plastin 1 |
increases expression |
ISO |
Caffeine results in increased expression of PLS1 protein |
CTD |
PMID:31195006 |
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NCBI chr 8:103,557,361...103,659,625
Ensembl chr 8:103,557,364...103,608,913
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G |
Pls3 |
plastin 3 |
decreases expression |
ISO |
Caffeine results in decreased expression of PLS3 protein |
CTD |
PMID:31195006 |
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NCBI chr X:119,030,311...119,124,268
Ensembl chr X:119,030,419...119,124,250
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G |
Pnp |
purine nucleoside phosphorylase |
increases expression |
EXP |
Caffeine results in increased expression of PNP protein |
CTD |
PMID:6149265 |
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NCBI chr15:27,875,883...27,883,566
Ensembl chr15:27,875,911...27,883,350
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G |
Pnpla8 |
patatin-like phospholipase domain containing 8 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785
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G |
Pomc |
proopiomelanocortin |
increases secretion |
EXP |
Caffeine results in increased secretion of POMC protein alternative form |
CTD |
PMID:22959462 |
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NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
decreases expression |
EXP |
Caffeine results in decreased expression of PPARA mRNA |
CTD |
PMID:30776459 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression |
ISO EXP |
Caffeine results in decreased expression of PPARG mRNA |
CTD |
PMID:23727198 |
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NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
increases expression |
EXP |
Caffeine results in increased expression of PPARGC1A mRNA |
CTD |
PMID:17516843 |
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NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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G |
Ppfibp1 |
PPFIA binding protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of PPFIBP1 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
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G |
Ppial4g |
peptidylprolyl isomerase A like 4G |
decreases expression |
ISO |
Caffeine results in decreased expression of PPIAL4G protein |
CTD |
PMID:31195006 |
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NCBI chr15:81,576,690...81,577,379
Ensembl chr15:81,576,888...81,577,379
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G |
Ppm1b |
protein phosphatase, Mg2+/Mn2+ dependent, 1B |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
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G |
Ppp2r2b |
protein phosphatase 2, regulatory subunit B, beta |
decreases expression |
ISO |
Caffeine results in decreased expression of PPP2R2B mRNA |
CTD |
PMID:18444173 |
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NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809
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G |
Ppp2r3c |
protein phosphatase 2, regulatory subunit B'', gamma |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 6:76,056,585...76,079,755
Ensembl chr 6:76,056,499...76,079,664
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G |
Prdx2 |
peroxiredoxin 2 |
increases expression |
ISO |
Caffeine results in increased expression of PRDX2 protein |
CTD |
PMID:31195006 |
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NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
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G |
Prelid1 |
PRELI domain containing 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of PRELID1 mRNA |
CTD |
PMID:11793227 |
|
NCBI chr17:9,834,245...9,837,285
Ensembl chr17:9,834,242...9,837,303
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
increases phosphorylation |
ISO |
Caffeine results in increased phosphorylation of PRKAA1 protein |
CTD |
PMID:28298333 |
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NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
increases expression |
EXP |
Caffeine results in increased expression of PRKAA2 mRNA |
CTD |
PMID:22583948 |
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NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
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G |
Prkaca |
protein kinase cAMP-activated catalytic subunit alpha |
decreases expression |
ISO EXP |
Caffeine results in decreased expression of PRKACA protein |
CTD |
PMID:30825513 |
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NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
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G |
Prkar1a |
protein kinase cAMP-dependent type I regulatory subunit alpha |
decreases expression |
EXP |
Caffeine results in decreased expression of PRKAR1A mRNA |
CTD |
PMID:29343424 |
|
NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
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G |
Prkcsh |
protein kinase C substrate 80K-H |
increases expression |
ISO |
Caffeine results in increased expression of PRKCSH protein |
CTD |
PMID:31195006 |
|
NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
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G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
multiple interactions |
ISO |
Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]] PRKDC protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene] |
CTD |
PMID:18158334 PMID:20888899 |
|
NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
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G |
Prmt3 |
protein arginine methyltransferase 3 |
decreases expression |
EXP |
Caffeine results in decreased expression of PRMT3 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 1:105,113,595...105,200,253
Ensembl chr 1:105,113,595...105,200,470
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G |
Prnp |
prion protein |
decreases expression |
ISO |
Caffeine results in decreased expression of PRNP mRNA |
CTD |
PMID:18444173 |
|
NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
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G |
Prorsd1 |
prolyl-tRNA synthetase associated domain containing 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of PRORSD1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr14:113,938,061...113,940,330
Ensembl chr14:113,938,061...113,940,330
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G |
Prph |
peripherin |
decreases expression |
ISO |
Caffeine results in decreased expression of PRPH protein |
CTD |
PMID:31195006 |
|
NCBI chr 7:140,742,406...140,746,197
Ensembl chr 7:140,742,418...140,746,197
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G |
Psma2 |
proteasome 20S subunit alpha 2 |
decreases expression |
ISO |
Caffeine results in decreased expression of PSMA2 protein |
CTD |
PMID:31195006 |
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NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342
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Psma5 |
proteasome 20S subunit alpha 5 |
increases expression |
ISO |
Caffeine results in increased expression of PSMA5 protein |
CTD |
PMID:31195006 |
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NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714
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Psmc3 |
proteasome 26S subunit, ATPase 3 |
decreases expression |
ISO |
Caffeine results in decreased expression of PSMC3 protein |
CTD |
PMID:31195006 |
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NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319
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Psmc4 |
proteasome 26S subunit, ATPase 4 |
increases expression |
ISO |
Caffeine results in increased expression of PSMC4 protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581
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Psmc5 |
proteasome 26S subunit, ATPase 5 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr10:94,445,877...94,451,811
Ensembl chr10:94,445,877...94,451,811
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G |
Psme3 |
proteasome activator subunit 3 |
decreases expression |
ISO |
Caffeine results in decreased expression of PSME3 mRNA |
CTD |
PMID:11793227 |
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NCBI chr10:89,236,256...89,244,041
Ensembl chr10:89,236,256...89,244,041
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Ptgfrn |
prostaglandin F2 receptor inhibitor |
increases expression |
EXP |
Caffeine results in increased expression of PTGFRN mRNA |
CTD |
PMID:20864626 |
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NCBI chr 2:203,423,143...203,494,391
Ensembl chr 2:203,423,143...203,494,391
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G |
Ptgr1 |
prostaglandin reductase 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of PTGR1 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases expression multiple interactions |
ISO |
Caffeine results in decreased expression of PTGS2 protein Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:21561856 PMID:22974838 PMID:26852703 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Pwp2 |
PWP2, small subunit processome component |
decreases expression |
EXP |
Caffeine results in decreased expression of PWP2 mRNA |
CTD |
PMID:20864626 |
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NCBI chr20:11,228,892...11,243,204
Ensembl chr20:11,228,844...11,243,205
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G |
Qars1 |
glutaminyl-tRNA synthetase 1 |
increases expression |
EXP |
Caffeine results in increased expression of QARS1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702
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G |
Qrsl1 |
glutaminyl-tRNA amidotransferase subunit QRSL1 |
decreases expression |
EXP |
Caffeine results in decreased expression of QRSL1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr20:48,855,839...48,881,112
Ensembl chr20:48,855,914...48,881,119
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Rab3ip |
RAB3A interacting protein |
increases expression |
EXP |
Caffeine results in increased expression of RAB3IP mRNA |
CTD |
PMID:20864626 |
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NCBI chr 7:59,927,486...59,971,518
Ensembl chr 7:59,928,426...59,957,232
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Rab5c |
RAB5C, member RAS oncogene family |
decreases expression |
ISO |
Caffeine results in decreased expression of RAB5C protein |
CTD |
PMID:31195006 |
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NCBI chr10:88,621,924...88,645,364
Ensembl chr10:88,621,925...88,645,364
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Rab7a |
RAB7A, member RAS oncogene family |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173
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Rabgef1 |
RAB guanine nucleotide exchange factor 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of RABGEF1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959
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Rabl3 |
RAB, member of RAS oncogene family-like 3 |
decreases expression |
EXP |
Caffeine results in decreased expression of RABL3 mRNA |
CTD |
PMID:20864626 |
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NCBI chr11:66,049,635...66,078,669
Ensembl chr11:66,049,635...66,078,669
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Rac2 |
Rac family small GTPase 2 |
increases expression |
ISO |
Caffeine results in increased expression of RAC2 protein |
CTD |
PMID:31195006 |
|
NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
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G |
Rad1 |
RAD1 checkpoint DNA exonuclease |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 2:60,461,513...60,469,646
Ensembl chr 2:60,461,551...60,469,685
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G |
Rad50 |
RAD50 double strand break repair protein |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAD50 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
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Rad51ap1 |
RAD51 associated protein 1 |
increases expression |
ISO |
Caffeine results in increased expression of RAD51AP1 protein |
CTD |
PMID:20025956 |
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NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
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G |
Ralgapb |
Ral GTPase activating protein non-catalytic subunit beta |
decreases expression |
ISO |
Caffeine results in decreased expression of RALGAPB protein |
CTD |
PMID:31195006 |
|
NCBI chr 3:154,910,291...154,983,021
Ensembl chr 3:154,905,141...154,983,021
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Ran |
RAN, member RAS oncogene family |
increases expression |
ISO |
Caffeine results in increased expression of RAN protein |
CTD |
PMID:31195006 |
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NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
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G |
Rasa3 |
RAS p21 protein activator 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr16:81,320,090...81,434,239
Ensembl chr16:81,318,633...81,434,363
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Rb1 |
RB transcriptional corepressor 1 |
decreases phosphorylation |
ISO |
Caffeine results in decreased phosphorylation of RB1 protein |
CTD |
PMID:15126379 PMID:21229324 |
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NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
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G |
Rbbp4 |
RB binding protein 4, chromatin remodeling factor |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240
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G |
Rbbp5 |
RB binding protein 5, histone lysine methyltransferase complex subunit |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr13:49,250,301...49,277,152
Ensembl chr13:49,250,301...49,277,152
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G |
Rbm12 |
RNA binding motif protein 12 |
decreases expression |
EXP |
Caffeine results in decreased expression of RBM12 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417 Ensembl chr 3:151,641,095...151,658,417 Ensembl chr 3:151,641,095...151,658,417 Ensembl chr 3:151,641,095...151,658,417
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Rbmx |
RNA binding motif protein, X-linked |
decreases expression |
ISO |
Caffeine results in decreased expression of RBMX protein |
CTD |
PMID:31195006 |
|
NCBI chr X:159,881,835...159,891,405
Ensembl chr X:159,884,885...159,891,326
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] |
CTD |
PMID:22974838 PMID:26852703 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Ren |
renin |
increases expression increases secretion increases activity |
EXP ISO |
Caffeine results in increased expression of REN protein Caffeine results in increased secretion of REN protein Caffeine results in increased activity of REN protein |
CTD |
PMID:1860718 PMID:3020089 PMID:3044993 PMID:8244516 PMID:10803761 |
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NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
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Rgs2 |
regulator of G-protein signaling 2 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RGS2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
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Rhebl1 |
RHEB like 1 |
increases expression |
EXP |
Caffeine results in increased expression of RHEBL1 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639
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G |
Rims2 |
regulating synaptic membrane exocytosis 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of RIMS2 mRNA |
CTD |
PMID:20864626 |
|
NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138
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G |
Rnf166 |
ring finger protein 166 |
increases expression |
EXP |
Caffeine results in increased expression of RNF166 mRNA |
CTD |
PMID:20864626 |
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NCBI chr19:55,290,563...55,300,403
Ensembl chr19:55,290,563...55,300,403
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G |
Rnh1 |
ribonuclease/angiogenin inhibitor 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of RNH1 protein |
CTD |
PMID:31195006 |
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NCBI chr 1:214,151,341...214,163,807
Ensembl chr 1:214,151,338...214,163,808
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G |
Rpia |
ribose 5-phosphate isomerase A |
decreases expression |
EXP |
Caffeine results in decreased expression of RPIA mRNA |
CTD |
PMID:20864626 |
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NCBI chr 4:98,568,028...98,593,664
Ensembl chr 4:98,568,028...98,593,664
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Rpl10a |
ribosomal protein L10A |
decreases expression |
ISO |
Caffeine results in decreased expression of RPL10A protein |
CTD |
PMID:31195006 |
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NCBI chr20:7,908,309...7,910,867
Ensembl chr20:7,908,304...7,910,867
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Rpl13 |
ribosomal protein L13 |
decreases expression |
ISO |
Caffeine results in decreased expression of RPL13 protein |
CTD |
PMID:31195006 |
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NCBI chr19:55,917,489...55,920,040
Ensembl chr19:55,917,736...55,919,996
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Rpl17 |
ribosomal protein L17 |
increases expression |
ISO |
Caffeine results in increased expression of RPL17 protein |
CTD |
PMID:31195006 |
|
NCBI chr18:70,969,733...70,972,839
Ensembl chr18:70,970,596...70,975,494
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G |
Rpl26 |
ribosomal protein L26 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
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Rpl27a |
ribosomal protein L27a |
increases expression |
ISO |
Caffeine results in increased expression of RPL27A protein |
CTD |
PMID:31195006 |
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NCBI chr 1:174,132,798...174,135,816
Ensembl chr 1:174,132,798...174,135,816
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G |
Rpl29 |
ribosomal protein L29 |
increases expression |
ISO |
Caffeine results in increased expression of RPL29 protein |
CTD |
PMID:31195006 |
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NCBI chr 8:115,131,228...115,133,401
Ensembl chr 8:115,131,367...115,133,401
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G |
Rpl36 |
ribosomal protein L36 |
increases expression |
ISO |
Caffeine results in increased expression of RPL36 protein |
CTD |
PMID:31195006 |
|
NCBI chr 9:10,441,228...10,441,981
Ensembl chr 9:10,441,259...10,441,834
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Rpl36a |
ribosomal protein L36a |
decreases expression |
ISO |
Caffeine results in decreased expression of RPL36A protein |
CTD |
PMID:31195006 |
|
NCBI chr X:105,402,867...105,405,580
Ensembl chr X:105,402,867...105,405,580
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G |
Rpl4 |
ribosomal protein L4 |
increases expression |
ISO |
Caffeine results in increased expression of RPL4 protein |
CTD |
PMID:31195006 |
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NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805
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G |
Rpl5 |
ribosomal protein L5 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RPL5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] |
CTD |
PMID:20230807 |
|
NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
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Rpl7a |
ribosomal protein L7a |
increases expression |
ISO |
Caffeine results in increased expression of RPL7A protein |
CTD |
PMID:31195006 |
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NCBI chr 3:5,458,985...5,461,627
Ensembl chr 3:5,459,160...5,461,583 Ensembl chr 3:5,459,160...5,461,583
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Rpn1 |
ribophorin I |
increases expression |
ISO |
Caffeine results in increased expression of RPN1 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:119,997,232...120,018,687
Ensembl chr 4:119,997,268...120,018,679
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Rpn2 |
ribophorin II |
increases expression |
ISO |
Caffeine results in increased expression of RPN2 protein |
CTD |
PMID:31195006 |
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NCBI chr 3:153,398,373...153,445,633
Ensembl chr 3:153,398,130...153,445,632
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G |
Rps11 |
ribosomal protein S11 |
increases expression |
ISO |
Caffeine results in increased expression of RPS11 protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:101,116,641...101,118,749
Ensembl chr 1:101,116,635...101,118,825
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Rps14 |
ribosomal protein S14 |
increases expression |
ISO |
Caffeine results in increased expression of RPS14 protein |
CTD |
PMID:31195006 |
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NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316
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Rps18 |
ribosomal protein S18 |
increases expression |
ISO |
Caffeine results in increased expression of RPS18 protein |
CTD |
PMID:31195006 |
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NCBI chr20:5,441,875...5,445,553
Ensembl chr20:5,441,876...5,445,553
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Rps19 |
ribosomal protein S19 |
decreases expression |
ISO |
Caffeine results in decreased expression of RPS19 protein |
CTD |
PMID:31195006 |
|
NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627
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G |
Rps20 |
ribosomal protein S20 |
decreases expression |
ISO |
Caffeine results in decreased expression of RPS20 protein |
CTD |
PMID:31195006 |
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NCBI chr 5:16,706,052...16,707,214
Ensembl chr 5:16,706,082...16,706,909
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G |
Rps28 |
ribosomal protein S28 |
decreases expression |
ISO |
Caffeine results in decreased expression of RPS28 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440
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G |
Rps3a |
ribosomal protein S3a |
increases expression |
ISO |
Caffeine results in increased expression of RPS3A protein |
CTD |
PMID:31195006 |
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NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897
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G |
Rps6 |
ribosomal protein S6 |
decreases expression |
ISO EXP |
Caffeine results in decreased expression of RPS6 protein modified form |
CTD |
PMID:21081844 |
|
NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148 Ensembl chr 5:105,197,857...105,200,148
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Rps6ka3 |
ribosomal protein S6 kinase A3 |
decreases expression |
ISO |
Caffeine results in decreased expression of RPS6KA3 mRNA |
CTD |
PMID:11793227 |
|
NCBI chr X:37,469,736...37,576,055
Ensembl chr X:37,469,937...37,575,624
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases expression |
ISO EXP |
Caffeine results in decreased expression of RPS6KB1 protein modified form |
CTD |
PMID:21081844 |
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NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
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G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
multiple interactions |
ISO |
Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein] |
CTD |
PMID:22403396 |
|
NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
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G |
Rrs1 |
ribosome biogenesis regulator 1 homolog |
increases expression |
ISO |
Caffeine results in increased expression of RRS1 mRNA |
CTD |
PMID:11793227 |
|
NCBI chr 5:9,430,710...9,432,343
Ensembl chr 5:9,430,728...9,432,343
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G |
Rspo3 |
R-spondin 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:30,681,648...30,768,038
Ensembl chr 1:30,681,681...30,766,860
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G |
Runx2 |
RUNX family transcription factor 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of RUNX2 mRNA |
CTD |
PMID:30423288 PMID:31874197 |
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NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
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G |
Rwdd2b |
RWD domain containing 2B |
decreases expression |
EXP |
Caffeine results in decreased expression of RWDD2B mRNA |
CTD |
PMID:20864626 |
|
NCBI chr11:27,085,708...27,094,364
Ensembl chr11:27,085,711...27,094,364
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G |
Ryr1 |
ryanodine receptor 1 |
increases activity increases response to substance multiple interactions |
ISO |
Caffeine results in increased activity of RYR1 protein RYR1 gene mutant form results in increased susceptibility to Caffeine; RYR1 protein mutant form results in increased susceptibility to Caffeine [Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium; RYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium] TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein] |
CTD |
PMID:14641996 PMID:15210166 PMID:16372898 PMID:16484216 PMID:18719443 PMID:19191329 PMID:21485675 |
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NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
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Ryr2 |
ryanodine receptor 2 |
multiple interactions |
EXP |
Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]; HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] |
CTD |
PMID:12887973 |
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NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
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S100a10 |
S100 calcium binding protein A10 |
increases expression |
ISO |
Caffeine results in increased expression of S100A10 protein |
CTD |
PMID:31195006 |
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NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
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S100a6 |
S100 calcium binding protein A6 |
decreases expression |
ISO |
Caffeine results in decreased expression of S100A6 protein |
CTD |
PMID:31195006 |
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NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
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G |
Sap18 |
Sin3A associated protein 18 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SAP18 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SAP18 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr15:38,069,320...38,073,625
Ensembl chr15:38,069,320...38,073,622
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Sc5d |
sterol-C5-desaturase |
decreases expression |
EXP |
Caffeine results in decreased expression of SC5D mRNA |
CTD |
PMID:25868845 |
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NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
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G |
Scarb1 |
scavenger receptor class B, member 1 |
decreases expression multiple interactions increases methylation |
EXP |
Caffeine results in decreased expression of SCARB1 mRNA; Caffeine results in decreased expression of SCARB1 protein Caffeine inhibits the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 protein] Caffeine results in increased methylation of SCARB1 promoter |
CTD |
PMID:25868845 PMID:29800656 PMID:29958987 |
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NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
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Scd |
stearoyl-CoA desaturase |
decreases expression multiple interactions |
EXP ISO |
Caffeine results in decreased expression of SCD1 mRNA [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA |
CTD |
PMID:20864626 PMID:28843594 |
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NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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Scfd1 |
sec1 family domain containing 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of SCFD1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 6:72,124,408...72,202,703
Ensembl chr 6:72,124,417...72,202,713
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G |
Sec13 |
SEC13 homolog, nuclear pore and COPII coat complex component |
decreases expression |
ISO |
Caffeine results in decreased expression of SEC13 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 4:145,686,186...145,699,577
Ensembl chr 4:145,686,193...145,699,577
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Sec23a |
Sec23 homolog A, COPII coat complex component |
decreases expression |
ISO |
Caffeine results in decreased expression of SEC23A mRNA |
CTD |
PMID:11793227 |
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NCBI chr 6:80,059,742...80,107,340
Ensembl chr 6:80,060,916...80,107,236
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G |
Senp6 |
SUMO specific peptidase 6 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SENP6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:87,486,050...87,568,088
Ensembl chr 8:87,486,427...87,563,652
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G |
Septin7 |
septin 7 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 8:26,412,910...26,476,615
Ensembl chr 8:26,413,233...26,476,611
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G |
Serbp1 |
Serpine1 mRNA binding protein 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of SERBP1 protein |
CTD |
PMID:31195006 |
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NCBI chr 4:98,027,563...98,044,717
Ensembl chr 4:98,027,554...98,044,566
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G |
Serpina1 |
serpin family A member 1 |
increases expression |
ISO |
Caffeine results in increased expression of SERPINA1 mRNA |
CTD |
PMID:18444173 |
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NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
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G |
Serpina6 |
serpin family A member 6 |
decreases expression |
ISO |
Caffeine results in decreased expression of SERPINA6 mRNA |
CTD |
PMID:11793227 |
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NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247
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G |
Sfpq |
splicing factor proline and glutamine rich |
multiple interactions increases expression |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA] Caffeine results in increased expression of SFPQ protein |
CTD |
PMID:20230807 PMID:31195006 |
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NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
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G |
Sfrp1 |
secreted frizzled-related protein 1 |
multiple interactions |
EXP |
Caffeine inhibits the reaction [Doxorubicin results in increased secretion of SFRP1 protein] |
CTD |
PMID:30377735 |
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NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
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G |
Sh2b2 |
SH2B adaptor protein 2 |
increases expression |
EXP |
Caffeine results in increased expression of APS mRNA |
CTD |
PMID:20864626 |
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NCBI chr12:23,471,477...23,501,043
Ensembl chr12:23,473,270...23,501,036
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G |
Sharpin |
SHANK-associated RH domain interactor |
increases expression |
EXP |
Caffeine results in increased expression of SHARPIN mRNA |
CTD |
PMID:20864626 |
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NCBI chr 7:117,413,151...117,417,455
Ensembl chr 7:117,413,152...117,417,363
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G |
Sigmar1 |
sigma non-opioid intracellular receptor 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of SIGMAR1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681
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G |
Sirt1 |
sirtuin 1 |
decreases expression multiple interactions |
EXP ISO |
Caffeine results in decreased expression of SIRT1 mRNA; Caffeine results in decreased expression of SIRT1 protein 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA] |
CTD |
PMID:30776459 PMID:30825513 |
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NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
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G |
Sirt3 |
sirtuin 3 |
multiple interactions |
ISO |
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein] |
CTD |
PMID:30555576 |
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NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions increases expression |
ISO |
Caffeine affects the reaction [SLC16A1 protein results in increased uptake of Butyrates] Caffeine results in increased expression of SLC16A1 mRNA |
CTD |
PMID:19023563 |
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NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
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G |
Slc17a5 |
solute carrier family 17 member 5 |
increases expression |
EXP |
Caffeine results in increased expression of SLC17A5 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 8:85,891,245...85,926,466
Ensembl chr 8:85,891,257...85,926,450
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G |
Slc1a1 |
solute carrier family 1 member 1 |
decreases activity multiple interactions |
EXP |
Caffeine results in decreased activity of SLC1A1 protein Caffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein] |
CTD |
PMID:23262392 |
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NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056
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G |
Slc25a37 |
solute carrier family 25 member 37 |
decreases expression |
EXP |
Caffeine results in decreased expression of SLC25A37 mRNA |
CTD |
PMID:20864626 |
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NCBI chr15:51,125,764...51,168,384
Ensembl chr15:51,128,268...51,168,384
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G |
Slc2a1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
Caffeine results in increased expression of SLC2A1 protein |
CTD |
PMID:25486098 |
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NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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G |
Slc2a10 |
solute carrier family 2 member 10 |
decreases expression |
ISO |
Caffeine results in decreased expression of SLC2A10 protein |
CTD |
PMID:31195006 |
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NCBI chr 3:162,182,156...162,194,610
Ensembl chr 3:162,181,974...162,194,804
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G |
Slc2a3 |
solute carrier family 2 member 3 |
increases expression |
ISO |
Caffeine results in increased expression of SLC2A3 protein |
CTD |
PMID:25486098 |
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NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 Ensembl chr 4:155,408,233...155,631,856
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Slc30a7 |
solute carrier family 30 member 7 |
decreases expression |
EXP |
Caffeine results in decreased expression of SLC30A7 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030
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G |
Slc47a1 |
solute carrier family 47 member 1 |
multiple interactions |
ISO |
Caffeine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
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G |
Slc47a2 |
solute carrier family 47 member 2 |
multiple interactions |
ISO |
Caffeine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:22419765 |
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NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
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G |
Slc6a15 |
solute carrier family 6 member 15 |
multiple interactions |
ISO |
[Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA; [Caffeine co-treated with S 20098] results in decreased expression of SLC6A15 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA; [Fluoxetine co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA |
CTD |
PMID:29107002 PMID:29882086 |
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NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229
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G |
Slc6a3 |
solute carrier family 6 member 3 |
increases response to substance affects response to substance |
ISO |
SLC6A3 gene mutant form results in increased susceptibility to Caffeine SLC6A3 gene polymorphism affects the susceptibility to Caffeine |
CTD |
PMID:11222668 PMID:24403155 |
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NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
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G |
Slc8b1 |
solute carrier family 8 member B1 |
increases expression |
EXP |
Caffeine results in increased expression of SLC8B1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr12:41,566,980...41,590,294
Ensembl chr12:41,566,981...41,590,244
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G |
Smad1 |
SMAD family member 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
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G |
Smad2 |
SMAD family member 2 |
decreases expression |
EXP |
Caffeine results in decreased expression of SMAD2 mRNA; Caffeine results in decreased expression of SMAD2 protein |
CTD |
PMID:32663519 |
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NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
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G |
Smad3 |
SMAD family member 3 |
multiple interactions decreases expression |
ISO EXP |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA] Caffeine results in decreased expression of SMAD3 mRNA |
CTD |
PMID:20230807 PMID:32663519 |
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NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
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G |
Smox |
spermine oxidase |
increases expression |
ISO |
Caffeine results in increased expression of SMOX mRNA |
CTD |
PMID:11793227 |
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NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
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G |
Smpd3 |
sphingomyelin phosphodiesterase 3 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMPD3 mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
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G |
Snx3 |
sorting nexin 3 |
increases expression |
EXP |
Caffeine results in increased expression of SNX3 mRNA |
CTD |
PMID:20864626 |
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NCBI chr20:47,225,382...47,263,390
Ensembl chr20:47,225,619...47,263,390
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
[Caffeine co-treated with bisphenol A] results in decreased expression of SOD1 mRNA |
CTD |
PMID:31756439 |
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NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
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G |
Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
EXP ISO |
Caffeine results in increased expression of SOD2 protein [Caffeine co-treated with bisphenol A] results in decreased expression of SOD2 mRNA |
CTD |
PMID:23099337 PMID:31756439 |
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NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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G |
Sorl1 |
sortilin related receptor 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of SORL1 mRNA |
CTD |
PMID:25868845 |
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NCBI chr 8:46,228,077...46,287,171
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G |
Sowaha |
sosondowah ankyrin repeat domain family member A |
increases expression |
ISO |
Caffeine results in increased expression of SOWAHA protein |
CTD |
PMID:31195006 |
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NCBI chr10:38,836,158...38,838,932
Ensembl chr10:38,836,614...38,838,272
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G |
Sox9 |
SRY-box transcription factor 9 |
decreases expression |
EXP |
Caffeine results in decreased expression of SOX9 mRNA; Caffeine results in decreased expression of SOX9 protein |
CTD |
PMID:31874197 PMID:32663519 |
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NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
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G |
Spp1 |
secreted phosphoprotein 1 |
decreases expression |
EXP |
Caffeine results in decreased expression of SPP1 mRNA |
CTD |
PMID:30423288 |
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NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
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G |
Sqle |
squalene epoxidase |
decreases expression increases expression |
EXP ISO |
Caffeine results in decreased expression of SQLE mRNA Caffeine results in increased expression of SQLE mRNA |
CTD |
PMID:11793227 PMID:20864626 PMID:25868845 |
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NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
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G |
Sqstm1 |
sequestosome 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
Caffeine results in increased expression of SQSTM1 mRNA Caffeine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein] Caffeine results in decreased expression of SQSTM1 protein |
CTD |
PMID:20864626 PMID:21081844 PMID:22927544 |
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NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
increases expression |
EXP |
Caffeine results in increased expression of SREBF1 mRNA; Caffeine results in increased expression of SREBF1 protein |
CTD |
PMID:30776459 |
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NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Srebf2 |
sterol regulatory element binding transcription factor 2 |
increases expression multiple interactions |
EXP ISO |
Caffeine results in increased expression of SREBF2 mRNA; Caffeine results in increased expression of SREBF2 protein 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA] |
CTD |
PMID:30825513 |
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NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
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G |
Srp9 |
signal recognition particle 9 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447
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G |
Srsf1 |
serine and arginine rich splicing factor 1 |
decreases expression |
ISO |
Caffeine results in decreased expression of SRSF1 mRNA |
CTD |
PMID:11793227 |
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NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
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G |
Srsf2 |
serine and arginine rich splicing factor 2 |
increases expression |
ISO |
Caffeine results in increased expression of SRSF2 protein |
CTD |
PMID:31195006 |
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NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958
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G |
Ssc4d |
scavenger receptor cysteine rich family member with 4 domains |
increases expression |
ISO |
Caffeine results in increased expression of SSC4D protein |
CTD |
PMID:31195006 |
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NCBI chr12:23,752,823...23,769,466
Ensembl chr12:23,752,844...23,762,877
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G |
St13 |
ST13, Hsp70 interacting protein |
increases expression |
ISO |
Caffeine results in increased expression of ST13 protein |
CTD |
PMID:31195006 |
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NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
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Star |
steroidogenic acute regulatory protein |
decreases methylation increases expression decreases expression |
ISO EXP |
Caffeine results in decreased methylation of STAR promoter Caffeine results in increased expression of STAR mRNA Caffeine results in decreased expression of STAR mRNA Caffeine results in increased expression of STAR mRNA; Caffeine results in increased expression of STAR protein |
CTD |
PMID:22100783 PMID:24717552 PMID:25868845 PMID:30528684 |
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NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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G |
Stard4 |
StAR-related lipid transfer domain containing 4 |
decreases expression |
EXP |
Caffeine results in decreased expression of STARD4 mRNA |
CTD |
PMID:20864626 |
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NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
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G |
Stim1 |
stromal interaction molecule 1 |
increases expression |
EXP |
Caffeine results in increased expression of STIM1 mRNA |
CTD |
PMID:20864626 |
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NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420
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G |
Stip1 |
stress-induced phosphoprotein 1 |
multiple interactions |
ISO |
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STIP1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA] |
CTD |
PMID:20230807 |
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NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148
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G |
Stmn1 |
stathmin 1 |
increases expression |
ISO |
Caffeine results in increased expression of STMN1 protein |
CTD |
PMID:20025956 |
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NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
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G |
Strbp |
spermatid perinuclear RNA binding protein |
decreases expression |
ISO |
Caffeine results in decreased expression of STRBP mRNA |
CTD |
PMID:11793227 |
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