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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
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Accession:CHEBI:50925 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
Synonyms:related_synonym: A-kinase inhibitor;   A-kinase inhibitors;   AP50 kinase inhibitor;   AP50 kinase inhibitors;   ATP-protein transphosphorylase inhibitor;   ATP-protein transphosphorylase inhibitors;   ATP:protein phosphotransferase (non-specific) inhibitor;   ATP:protein phosphotransferase (non-specific) inhibitors;   BR serine/threonine-protein kinase 2 inhibitor;   BR serine/threonine-protein kinase 2 inhibitors;   CK-2 inhibitor;   CK-2 inhibitors;   CKI inhibitor;   CKI inhibitors;   CKII inhibitor;   CKII inhibitors;   EC 2.7.11.1 inhibitor;   EC 2.7.11.1 inhibitors;   HIPK2 inhibitor;   HIPK2 inhibitors;   Hpr kinase inhibitor;   Hpr kinase inhibitors;   M phase-specific cdc2 kinase inhibitor;   M phase-specific cdc2 kinase inhibitors;   MKNK2 inhibitor;   MKNK2 inhibitors;   PAK-1 inhibitor;   PAK-1 inhibitors;   PAK1 inhibitor;   PAK1 inhibitors;   PKA inhibitor;   PKA inhibitors;   Prp4 protein kinase inhibitor;   Prp4 protein kinase inhibitors;   Raf kinase inhibitor;   Raf kinase inhibitors;   Raf-1 inhibitor;   Raf-1 inhibitors;   STK32 inhibitor;   STK32 inhibitors;   T-antigen kinase inhibitor;   T-antigen kinase inhibitors;   WEE1Hu inhibitor;   WEE1Hu inhibitors;   Wee 1-like kinase inhibitor;   Wee 1-like kinase inhibitors;   Wee-kinase inhibitor;   Wee-kinase inhibitors;   betaIIPKC inhibitor;   betaIIPKC inhibitors;   cAMP-dependent protein kinase A inhibitor;   cAMP-dependent protein kinase A inhibitors;   cAMP-dependent protein kinase inhibitor;   cAMP-dependent protein kinase inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   calcium-dependent protein kinase C inhibitor;   calcium-dependent protein kinase C inhibitors;   calcium/phospholipid-dependent protein kinase inhibitor;   calcium/phospholipid-dependent protein kinase inhibitors;   casein kinase (phosphorylating) inhibitor;   casein kinase (phosphorylating) inhibitors;   casein kinase 2 inhibitor;   casein kinase 2 inhibitors;   casein kinase I inhibitor;   casein kinase I inhibitors;   casein kinase II inhibitor;   casein kinase II inhibitors;   casein kinase inhibitor;   casein kinase inhibitors;   cyclic AMP-dependent protein kinase A inhibitor;   cyclic AMP-dependent protein kinase A inhibitors;   cyclic AMP-dependent protein kinase inhibitor;   cyclic AMP-dependent protein kinase inhibitors;   cyclic monophosphate-dependent protein kinase inhibitor;   cyclic monophosphate-dependent protein kinase inhibitors;   cyclic nucleotide-dependent protein kinase inhibitor;   cyclic nucleotide-dependent protein kinase inhibitors;   cyclin-dependent kinase inhibitor;   cyclin-dependent kinase inhibitors;   dsk1 inhibitor;   dsk1 inhibitors;   epsilon PKC inhibitor;   epsilon PKC inhibitors;   glycogen synthase a kinase inhibitor;   glycogen synthase a kinase inhibitors;   glycogen synthase kinase inhibitor;   glycogen synthase kinase inhibitors;   hydroxyalkyl-protein kinase inhibitor;   hydroxyalkyl-protein kinase inhibitors;   mitogen-activated S6 kinase inhibitor;   mitogen-activated S6 kinase inhibitors;   non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors;   non-specific serine/threonine protein kinase inhibitor;   non-specific serine/threonine protein kinase inhibitors;   p21 activated kinase-1 inhibitor;   p21 activated kinase-1 inhibitors;   p82 kinase inhibitor;   p82 kinase inhibitors;   phosphorylase b kinase kinase inhibitor;   phosphorylase b kinase kinase inhibitors;   protein glutamyl kinase inhibitor;   protein glutamyl kinase inhibitors;   protein kinase (phosphorylating) inhibitor;   protein kinase (phosphorylating) inhibitors;   protein kinase A inhibitor;   protein kinase A inhibitors;   protein kinase CK2 inhibitor;   protein kinase CK2 inhibitors;   protein kinase p58 inhibitor;   protein kinase p58 inhibitors;   protein phosphokinase inhibitor;   protein phosphokinase inhibitors;   protein serine kinase inhibitor;   protein serine kinase inhibitors;   protein-aspartyl kinase inhibitor;   protein-aspartyl kinase inhibitors;   protein-cysteine kinase inhibitor;   protein-cysteine kinase inhibitors;   ribosomal S6 protein kinase inhibitor;   ribosomal S6 protein kinase inhibitors;   ribosomal protein S6 kinase II inhibitor;   ribosomal protein S6 kinase II inhibitors;   serine kinase inhibitor;   serine kinase inhibitors;   serine-specific protein kinase inhibitor;   serine-specific protein kinase inhibitors;   serine/threonine protein kinase inhibitor;   serine/threonine protein kinase inhibitors;   threonine-specific protein kinase inhibitor;   threonine-specific protein kinase inhibitors;   twitchin kinase inhibitor;   twitchin kinase inhibitors;   type-2 casein kinase inhibitor;   type-2 casein kinase inhibitors
 alt_id: CHEBI:75764

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6-bromoindirubin-3'-oxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO
EXP		 6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of ABCB1 protein
6-bromoindirubin-3'-oxime results in increased expression of ABCB1 mRNA
6-bromoindirubin-3'-oxime results in increased expression of ABCB1A mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCB1A protein		 CTD PMID:18624906 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO 6-bromoindirubin-3'-oxime results in increased expression of ABCC2 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCC2 protein CTD PMID:18624906 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO 6-bromoindirubin-3'-oxime results in increased expression of ABCC4 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCC4 protein CTD PMID:18624906 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO 6-bromoindirubin-3'-oxime results in increased expression of ABCG2 mRNA; 6-bromoindirubin-3'-oxime results in increased expression of ABCG2 protein CTD PMID:18624906 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO 6-bromoindirubin-3'-oxime binds to and results in increased activity of AHR protein CTD PMID:26259606 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [sorafenib co-treated with 6-bromoindirubin-3'-oxime] affects the localization of AIFM1 protein CTD PMID:17991738 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of CASP8 protein modified form] CTD PMID:28414160 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO
EXP		 6-bromoindirubin-3'-oxime results in increased expression of CCND1 mRNA CTD PMID:18624906 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdx1 caudal type homeo box 1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in increased expression of CDX1 mRNA CTD PMID:27693483 NCBI chr18:56,337,485...56,355,477
Ensembl chr18:56,338,336...56,355,490 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases phosphorylation		 ISO [6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein; broussochalcone A inhibits the reaction [6-bromoindirubin-3'-oxime results in increased expression of CTNNB1 protein]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in decreased phosphorylation of CTNNB1 protein] CTD PMID:18624906 PMID:19727391 PMID:26259606 PMID:31163223 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions		 ISO 6-bromoindirubin-3'-oxime results in increased expression of CYP1A2 mRNA
6-bromoindirubin-3'-oxime results in increased expression of and results in increased activity of CYP1A2 protein		 CTD PMID:26259606 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of CYP26A1 mRNA CTD PMID:27693483 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to DDX3X protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of DDX3X protein modified form] CTD PMID:28414160 NCBI chr  X:10,400,363...10,414,010
Ensembl chr  X:10,400,366...10,413,995 		JBrowse link
G Dhfr dihydrofolate reductase multiple interactions ISO [6-bromoindirubin-3'-oxime co-treated with DHFR mRNA] affects the expression of CTNNB1 protein CTD PMID:19727391 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO 6-bromoindirubin-3'-oxime promotes the reaction [sorafenib affects the localization of DIABLO protein] CTD PMID:17991738 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3A protein modified form] CTD PMID:28414160 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity
multiple interactions
increases phosphorylation		 ISO 6-bromoindirubin-3'-oxime results in decreased activity of GSK3B protein
6-bromoindirubin-3'-oxime promotes the reaction [Paraquat inhibits the reaction [TNFRSF10B protein binds to GSK3B protein]]; 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in decreased expression of GSK3B protein modified form]; Methotrexate promotes the reaction [6-bromoindirubin-3'-oxime results in increased phosphorylation of GSK3B protein]		 CTD PMID:17991738 PMID:19727391 PMID:28414160 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] affects the expression of HOXA1 mRNA CTD PMID:27693483 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [6-bromoindirubin-3'-oxime co-treated with Methotrexate] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:19727391 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 increases expression ISO 6-bromoindirubin-3'-oxime results in increased expression of LGR5 mRNA CTD PMID:26259606 NCBI chr 7:58,447,097...58,587,787
Ensembl chr 7:58,448,277...58,587,787 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO 6-bromoindirubin-3'-oxime results in decreased expression of MCL1 protein CTD PMID:17991738 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 6-bromoindirubin-3'-oxime promotes the reaction [Paraquat results in increased expression of PARP1 protein modified form] CTD PMID:28414160 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions ISO 6-bromoindirubin-3'-oxime inhibits the reaction [sorafenib results in decreased expression of PMAIP1 protein] CTD PMID:17991738 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of POU5F1 mRNA CTD PMID:27693483 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [6-bromoindirubin-3'-oxime co-treated with Methotrexate] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:19727391 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Wnt3 Wnt family member 3 multiple interactions ISO [Valproic Acid co-treated with 6-bromoindirubin-3'-oxime] results in decreased expression of WNT3 mRNA CTD PMID:27693483 NCBI chr10:91,830,709...91,874,907
Ensembl chr10:91,830,654...91,874,793 		JBrowse link
8-(3-chlorostyryl)caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor multiple interactions
increases response to substance		 EXP
ISO		 8-(3-chlorostyryl)caffeine binds to and results in decreased activity of ADORA2A protein; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A mRNA]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein]]; 8-(3-chlorostyryl)caffeine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of ADORA2A protein]
ADORA2A protein results in increased susceptibility to 8-(3-chlorostyryl)caffeine		 CTD PMID:11172060 PMID:15641640 PMID:18608257 PMID:19966059 PMID:21195062 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
multiple interactions		 ISO DRD2 protein affects the susceptibility to 8-(3-chlorostyryl)caffeine
DRD2 protein affects the susceptibility to [8-(3-chlorostyryl)caffeine co-treated with Reserpine]		 CTD PMID:11172060 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of FOS mRNA]; 8-(3-chlorostyryl)caffeine promotes the reaction [Quinpirole inhibits the reaction [Reserpine results in increased expression of FOS protein]] CTD PMID:8577368 PMID:10199625 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [[9-(2-hydroxy-3-nonyl)adenine co-treated with 4-nitrobenzylthioinosine] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]] CTD PMID:19966059 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nts neurotensin multiple interactions EXP 8-(3-chlorostyryl)caffeine inhibits the reaction [Haloperidol results in increased expression of NTS mRNA] CTD PMID:10199625 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130 		JBrowse link
alsterpaullone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases activity ISO alsterpaullone analog results in increased activity of AR protein CTD PMID:21111724 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP alsterpaullone inhibits the reaction [Colchicine results in increased activity of CASP3 protein] CTD PMID:20300959 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO alsterpaullone results in decreased activity of CDK2 protein CTD PMID:12534346 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO alsterpaullone results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO alsterpaullone results in decreased activity of LCK protein CTD PMID:12534346 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983 		JBrowse link
G Tp53 tumor protein p53 affects localization
multiple interactions		 ISO alsterpaullone affects the localization of TP53 protein
alsterpaullone results in decreased degradation of and results in increased expression of TP53 protein		 CTD PMID:16055726 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
caffeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCB4 mRNA CTD PMID:28843594 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC2 mRNA CTD PMID:28843594 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ABCC3 mRNA CTD PMID:28843594 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Acan aggrecan decreases expression EXP Caffeine results in decreased expression of ACAN mRNA CTD PMID:29966748 PMID:32663519 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 decreases expression ISO Caffeine results in decreased expression of ACAT2 mRNA CTD PMID:11793227 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653 		JBrowse link
G Ace angiotensin I converting enzyme increases expression
decreases methylation		 EXP Caffeine results in increased expression of ACE mRNA; Caffeine results in increased expression of ACE protein
Caffeine results in decreased methylation of ACE promoter		 CTD PMID:30423288 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity		 EXP caffeic acid inhibits the reaction [Caffeine results in decreased activity of ACHE protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of ACHE protein] CTD PMID:28465162 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression ISO Caffeine results in increased expression of ACIN1 mRNA CTD PMID:11793227 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417 		JBrowse link
G Acly ATP citrate lyase increases expression EXP Caffeine results in increased expression of ACLY mRNA CTD PMID:30776459 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 increases expression ISO Caffeine results in increased expression of ACSL3 mRNA CTD PMID:11793227 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression ISO Caffeine results in decreased expression of ACSL4 protein CTD PMID:31195006 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944 		JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression EXP Caffeine results in increased expression of ACTA2 mRNA CTD PMID:29055810 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Actb actin, beta decreases expression ISO Caffeine results in decreased expression of ACTB protein CTD PMID:31195006 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841 		JBrowse link
G Actbl2 actin, beta-like 2 increases expression ISO Caffeine results in increased expression of ACTBL2 protein CTD PMID:31195006 NCBI chr 2:42,829,413...42,832,160
Ensembl chr 2:42,829,413...42,832,160 		JBrowse link
G Actl6b actin-like 6B increases expression ISO Caffeine results in increased expression of ACTL6B protein CTD PMID:31195006 NCBI chr12:22,194,595...22,211,107
Ensembl chr12:22,194,618...22,211,080 		JBrowse link
G Actr1a actin related protein 1A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ACTR1A mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ACTR1A mRNA] CTD PMID:20230807 NCBI chr 1:266,123,864...266,142,621
Ensembl chr 1:266,123,870...266,142,538 		JBrowse link
G Ada adenosine deaminase increases expression EXP Caffeine results in increased expression of ADA protein CTD PMID:6149265 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 increases expression EXP Caffeine results in increased expression of ADAMTS5 mRNA CTD PMID:31874197 NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 decreases expression EXP Caffeine results in decreased expression of ADARB1 mRNA CTD PMID:20864626 NCBI chr20:11,972,352...12,101,022
Ensembl chr20:11,972,381...12,101,047 		JBrowse link
G Adcy5 adenylate cyclase 5 decreases expression EXP Caffeine results in decreased expression of ADCY5 mRNA CTD PMID:26367767 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320 		JBrowse link
G Adcy7 adenylate cyclase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADCY7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ADCY7 mRNA] CTD PMID:20230807 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081 		JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ADGRL1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ADGRL1 mRNA] CTD PMID:20230807 NCBI chr19:25,029,037...25,069,146
Ensembl chr19:25,029,037...25,069,142 		JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP Caffeine results in increased expression of ADIPOR2 mRNA CTD PMID:22583948 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894 		JBrowse link
G Adora1 adenosine A1 receptor multiple interactions
decreases expression
decreases activity
increases expression		 ISO
EXP		 [8-cyclopentyl-1,3-dimethylxanthine binds to and results in decreased activity of ADORA1 protein] inhibits the reaction [[Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine]; [Caffeine co-treated with [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]] results in decreased susceptibility to Methamphetamine; [Caffeine co-treated with Mianserin] results in decreased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of ADORA1 mRNA; [Fluoxetine co-treated with Caffeine deficiency] results in increased expression of ADORA1 mRNA
Caffeine deficiency results in decreased expression of ADORA1 mRNA
Caffeine results in decreased activity of ADORA1 protein
Caffeine results in decreased expression of ADORA1 mRNA
Caffeine inhibits the reaction [N(6)-cyclopentyladenosine binds to and results in increased activity of ADORA1 protein]; Caffeine promotes the reaction [Phenylisopropyladenosine binds to and results in increased activity of ADORA1 protein]
Caffeine results in increased expression of ADORA1 protein		 CTD PMID:3003150 PMID:7996441 PMID:10401785 PMID:12153486 PMID:15708489 PMID:22164264 PMID:23611293 PMID:29107002 PMID:29882086 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
decreases expression
multiple interactions
decreases activity
increases response to substance
affects binding		 ISO
EXP		 ADORA2A protein affects the susceptibility to Caffeine
Caffeine results in decreased expression of ADORA2A mRNA
Caffeine results in decreased expression of ADORA2A mRNA; Caffeine results in decreased expression of ADORA2A protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A mRNA]; 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of ADORA2A protein]
ADORA2A polymorphism affects the susceptibility to Caffeine
Caffeine results in decreased activity of ADORA2A protein
ADORA2A polymorphism results in increased susceptibility to Caffeine; ADORA2A SNP results in increased susceptibility to Caffeine
Caffeine analog binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to and results in decreased activity of ADORA2A protein; Caffeine binds to and results in decreased activity of ADORA2A protein
Caffeine analog binds to ADORA2A protein
ADORA2A protein results in increased susceptibility to Caffeine		 CTD PMID:10214707 PMID:11172060 PMID:12077927 PMID:12825092 PMID:15452191 PMID:16221767 PMID:16470403 PMID:16771831 PMID:18305461 PMID:20520601 PMID:21950736 PMID:23611293 PMID:26367767 PMID:30555576 PMID:30825513 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Adora2b adenosine A2B receptor multiple interactions
decreases expression		 ISO
EXP		 ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]
Caffeine results in decreased expression of ADORA2B mRNA		 CTD PMID:22701600 PMID:26367767 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365 		JBrowse link
G Agt angiotensinogen increases expression EXP Caffeine results in increased expression of AGT protein CTD PMID:30423288 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
decreases expression		 EXP Caffeine results in increased expression of AGTR1A
Caffeine results in decreased expression of AGTR1A mRNA		 CTD PMID:25986755 PMID:30423288 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP Caffeine results in decreased expression of AGTR2 mRNA; Caffeine results in decreased expression of AGTR2 protein CTD PMID:25986755 PMID:30423288 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Ahcy adenosylhomocysteinase decreases expression ISO Caffeine results in decreased expression of AHCY protein CTD PMID:31195006 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082 		JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression ISO Caffeine results in decreased expression of AKAP9 protein CTD PMID:31195006 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582 		JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of AKR1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AKR1A1 mRNA] CTD PMID:20230807 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
affects expression
decreases expression
decreases phosphorylation
increases phosphorylation
decreases response to substance		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]
Caffeine affects the expression of AKT1 mRNA
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
Caffeine results in decreased expression of AKT1 mRNA; Caffeine results in decreased expression of AKT1 protein modified form
Caffeine results in decreased phosphorylation of AKT1 protein
AKT1 results in decreased susceptibility to Caffeine		 CTD PMID:15126379 PMID:18201823 PMID:21081844 PMID:21561856 PMID:22974838 PMID:29966748 PMID:30528684 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression ISO Caffeine results in decreased expression of ALDH18A1 mRNA CTD PMID:11793227 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ALDH1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ALDH1A1 mRNA] CTD PMID:20230807 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression EXP Caffeine results in increased expression of ALDH9A1 mRNA CTD PMID:20864626 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of ALDOA mRNA CTD PMID:28843594 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588 		JBrowse link
G Alms1 ALMS1, centrosome and basal body associated protein decreases expression EXP Caffeine results in decreased expression of ALMS1 mRNA CTD PMID:25868845 NCBI chr 4:117,371,544...117,472,310
Ensembl chr 4:117,371,659...117,472,198 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated decreases expression EXP Caffeine results in decreased expression of ALPL mRNA CTD PMID:30423288 PMID:31874197 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537 		JBrowse link
G Ang angiogenin decreases expression ISO Caffeine results in decreased expression of ANG mRNA CTD PMID:11793227 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression EXP Caffeine results in decreased expression of ANKRD37 mRNA CTD PMID:20864626 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888 		JBrowse link
G Anxa11 annexin A11 decreases expression ISO Caffeine results in decreased expression of ANXA11 protein CTD PMID:31195006 NCBI chr16:3,867,193...3,912,043
Ensembl chr16:3,867,208...3,912,148 		JBrowse link
G Anxa4 annexin A4 decreases expression ISO Caffeine results in decreased expression of ANXA4 protein CTD PMID:31195006 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of APEX1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of APEX1 mRNA] CTD PMID:20230807 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
decreases expression		 ISO
EXP		 [Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein
Caffeine results in decreased expression of APOA1 mRNA		 CTD PMID:16324916 PMID:25868845 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions
decreases expression		 ISO
EXP		 [Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein
Caffeine results in decreased expression of APOA2 mRNA		 CTD PMID:16324916 PMID:25868845 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802 		JBrowse link
G Apob apolipoprotein B multiple interactions
decreases expression		 ISO
EXP		 [Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein
[Caffeine co-treated with Dietary Fats] results in increased expression of APOB mRNA
Caffeine results in decreased expression of APOB mRNA		 CTD PMID:16324916 PMID:25868845 PMID:29800656 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Apoc1 apolipoprotein C1 multiple interactions
decreases expression		 ISO
EXP		 [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein
Caffeine results in decreased expression of APOC1 mRNA		 CTD PMID:16324916 PMID:25868845 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921 		JBrowse link
G Apoc2 apolipoprotein C2 multiple interactions
decreases expression		 ISO
EXP		 [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein
Caffeine results in decreased expression of APOC2 mRNA		 CTD PMID:16324916 PMID:25868845 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136 		JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498 		JBrowse link
G Apom apolipoprotein M decreases expression EXP Caffeine results in decreased expression of APOM mRNA CTD PMID:25868845 NCBI chr20:5,120,473...5,123,073
Ensembl chr20:5,120,474...5,123,073 		JBrowse link
G Arcn1 archain 1 decreases expression ISO Caffeine results in decreased expression of ARCN1 protein CTD PMID:31195006 NCBI chr 8:49,051,257...49,075,861
Ensembl chr 8:49,051,246...49,075,892 		JBrowse link
G Arf1 ADP-ribosylation factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ARF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ARF1 mRNA] CTD PMID:20230807 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029 		JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 increases expression ISO Caffeine results in increased expression of ARL6IP1 mRNA CTD PMID:11793227 NCBI chr 1:187,770,160...187,779,675
Ensembl chr 1:187,770,160...187,779,675 		JBrowse link
G Arrb2 arrestin, beta 2 increases expression EXP Caffeine results in increased expression of ARRB2 mRNA CTD PMID:20864626 NCBI chr10:57,040,252...57,048,045
Ensembl chr10:57,040,267...57,048,134 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Caffeine results in decreased expression of ASNS mRNA CTD PMID:18444173 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atg7 autophagy related 7 increases response to substance ISO ATG7 protein results in increased susceptibility to Caffeine; ATG7 results in increased susceptibility to Caffeine CTD PMID:21081844 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
decreases activity		 ISO [[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased activity of ATM protein]; Caffeine inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in decreased activity of ATM protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [kaempferol results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
ATM protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]		 CTD PMID:10531013 PMID:11507241 PMID:15975956 PMID:18347191 PMID:19028473 PMID:19038232 PMID:20734998 PMID:20888899 PMID:22927544 PMID:23274516 PMID:31168028 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects response to substance ISO ATP2A2 protein affects the susceptibility to Caffeine CTD PMID:19328205 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Atp5mf ATP synthase membrane subunit f decreases expression ISO Caffeine results in decreased expression of ATP5MF mRNA CTD PMID:11793227 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369 		JBrowse link
G Atp6v0c ATPase H+ transporting V0 subunit C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V0C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V0C mRNA] CTD PMID:20230807 NCBI chr10:13,537,031...13,543,407
Ensembl chr10:13,537,033...13,542,077 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATP6V1B2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ATP6V1B2 mRNA] CTD PMID:20230807 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155 		JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 decreases expression EXP Caffeine results in decreased expression of ATPAF1 mRNA CTD PMID:20864626 NCBI chr 5:134,641,618...134,667,079
Ensembl chr 5:134,641,608...134,667,084 		JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
affects activity		 ISO [[Caffeine results in decreased activity of ATR protein] co-treated with [Caffeine results in decreased activity of ATM protein]] results in decreased susceptibility to Acrylamide; Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [ATM protein co-treated with ATR protein]]
Caffeine affects the activity of ATR protein		 CTD PMID:11507241 PMID:15975956 PMID:18158334 PMID:20734998 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Atrn attractin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ATRN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ATRN mRNA] CTD PMID:20230807 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of AVPR1A mRNA CTD PMID:28843594 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression ISO Caffeine results in increased expression of BASP1 protein CTD PMID:31195006 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Caffeine results in increased expression of BAX protein
[Caffeine co-treated with bisphenol A] results in increased expression of BAX mRNA		 CTD PMID:12811820 PMID:12907610 PMID:31756439 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions ISO Caffeine inhibits the reaction [kaempferol results in increased expression of BBC3 protein] CTD PMID:19028473 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of BCL2L1 mRNA CTD PMID:31756439 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Caffeine inhibits the reaction [aluminum chloride results in decreased expression of BDNF mRNA] CTD PMID:26339337 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein]		 CTD PMID:30555576 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Caffeine results in decreased expression of BGLAP mRNA CTD PMID:30423288 PMID:31874197 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of BHMT mRNA CTD PMID:28843594 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of BID protein] CTD PMID:16777994 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BNIP3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BNIP3 mRNA] CTD PMID:20230807 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase multiple interactions ISO [Nocodazole co-treated with Caffeine] results in increased expression of BUB1 protein modified form CTD PMID:21670593 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910 		JBrowse link
G C1r complement C1r multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of C1R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1R mRNA] CTD PMID:20230807 NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829 		JBrowse link
G C1s complement C1s multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of C1S mRNA] CTD PMID:20230807 NCBI chr 4:157,143,592...157,155,592
Ensembl chr 4:157,143,592...157,155,609 		JBrowse link
G C2cd5 C2 calcium-dependent domain containing 5 increases expression EXP Caffeine results in increased expression of C2CD5 mRNA CTD PMID:20864626 NCBI chr 4:177,245,868...177,331,910
Ensembl chr 4:177,245,868...177,331,915 		JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression EXP Caffeine results in increased expression of CAD protein CTD PMID:6149265 NCBI chr 6:26,657,507...26,680,459
Ensembl chr 6:26,657,780...26,680,284 		JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CALM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CALM1 mRNA] CTD PMID:20230807 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292 		JBrowse link
G Calu calumenin decreases expression ISO Caffeine results in decreased expression of CALU mRNA CTD PMID:11793227 NCBI chr 4:56,625,611...56,653,112
Ensembl chr 4:56,625,561...56,653,111 		JBrowse link
G Cand1 cullin-associated and neddylation-dissociated 1 decreases expression ISO Caffeine results in decreased expression of CAND1 protein CTD PMID:31195006 NCBI chr 7:62,124,362...62,162,451
Ensembl chr 7:62,124,362...62,162,453 		JBrowse link
G Capn1 calpain 1 multiple interactions ISO [Caffeine co-treated with Alprazolam] promotes the reaction [Calcium results in increased activity of CAPN1 protein] CTD PMID:19490937 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Capn2 calpain 2 decreases expression ISO Caffeine results in decreased expression of CAPN2 protein CTD PMID:31195006 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP2 protein] CTD PMID:16777994 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
increases expression
increases cleavage
increases activity
affects cleavage		 ISO
EXP		 [Caffeine co-treated with Alprazolam] results in increased cleavage of CASP3 protein; Caffeine inhibits the reaction [Oxidopamine results in increased activity of CASP3 protein]; Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP3 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP3 protein
Caffeine results in decreased expression of CASP3 protein modified form
Caffeine results in increased expression of CASP3 mRNA
Caffeine results in increased cleavage of CASP3 protein
Caffeine results in increased activity of CASP3 protein
[Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein
Caffeine affects the cleavage of CASP3 protein		 CTD PMID:12378022 PMID:12395097 PMID:12907610 PMID:15537744 PMID:16522534 PMID:16777994 PMID:18201823 PMID:18283038 PMID:19242509 PMID:19490937 PMID:19815060 PMID:21081844 PMID:21229324 PMID:31874197 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Caffeine inhibits the reaction [silybin results in increased cleavage of and results in increased activity of CASP9 protein]; Caffeine results in increased cleavage of and results in increased expression of CASP9 protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP9 mRNA]		 CTD PMID:16522534 PMID:16777994 PMID:20230807 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions
decreases expression
increases expression		 ISO
EXP		 Caffeine inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein]
Caffeine results in decreased expression of CAT mRNA
Caffeine results in increased expression of CAT protein
[Caffeine co-treated with Cadmium Chloride] results in decreased activity of CAT protein; [Caffeine co-treated with Cadmium Chloride] results in increased expression of CAT protein		 CTD PMID:22154906 PMID:23099337 PMID:25868845 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 increases expression ISO Caffeine results in increased expression of CAV1 protein CTD PMID:31195006 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Cav3 caveolin 3 decreases expression EXP Caffeine results in decreased expression of CAV3 mRNA CTD PMID:25868845 NCBI chr 4:144,382,945...144,398,919
Ensembl chr 4:144,382,945...144,398,917 		JBrowse link
G Cbx5 chromobox 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CBX5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CBX5 mRNA] CTD PMID:20230807 NCBI chr 7:144,819,673...144,865,014
Ensembl chr 7:144,819,420...144,837,583 		JBrowse link
G Ccdc124 coiled-coil domain containing 124 increases expression ISO Caffeine results in increased expression of CCDC124 protein CTD PMID:31195006 NCBI chr16:20,317,446...20,323,265
Ensembl chr16:20,317,446...20,323,265 		JBrowse link
G Ccdc174 coiled-coil domain containing 174 decreases expression EXP Caffeine results in decreased expression of CCDC174 mRNA CTD PMID:20864626 NCBI chr 4:123,760,708...123,787,529
Ensembl chr 4:123,760,743...123,787,528 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
decreases expression		 ISO Caffeine results in increased expression of CCL3 mRNA
Caffeine results in decreased expression of CCL3 mRNA		 CTD PMID:28089782 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression		 ISO Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein]
Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein]
Caffeine results in increased expression of CCNB1 protein		 CTD PMID:9098629 PMID:19038232 PMID:20025956 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein] CTD PMID:15126379 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnf cyclin F multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CCNF mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNF mRNA] CTD PMID:20230807 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935 		JBrowse link
G Ccng1 cyclin G1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CCNG1 mRNA CTD PMID:28843594 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325 		JBrowse link
G Ccnl2 cyclin L2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNL2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNL2 mRNA] CTD PMID:20230807 NCBI chr 5:173,256,301...173,268,279
Ensembl chr 5:173,256,637...173,276,169 		JBrowse link
G Cct8 chaperonin containing TCP1 subunit 8 decreases expression ISO Caffeine results in decreased expression of CCT8 protein CTD PMID:31195006 NCBI chr11:27,130,172...27,141,881
Ensembl chr11:27,130,172...27,141,881 		JBrowse link
G Cd36 CD36 molecule multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CD36 mRNA CTD PMID:28843594 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749 		JBrowse link
G Cd59 CD59 molecule increases expression ISO Caffeine results in increased expression of CD59 protein CTD PMID:31195006 NCBI chr 3:94,010,481...94,028,660
Ensembl chr 3:94,010,475...94,028,621 		JBrowse link
G Cd9 CD9 molecule decreases expression ISO Caffeine results in decreased expression of CD9 protein CTD PMID:31195006 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166 		JBrowse link
G Cdc14b cell division cycle 14B multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CDC14B mRNA CTD PMID:28843594 NCBI chr17:1,709,703...1,797,732
Ensembl chr17:1,703,943...1,797,750 		JBrowse link
G Cdc25b cell division cycle 25B increases expression EXP Caffeine results in increased expression of CDC25B mRNA CTD PMID:20864626 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression
multiple interactions		 ISO Caffeine results in decreased expression of CDC25C protein
Caffeine inhibits the reaction [CDC25C protein binds to YWHAQ protein]; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDC25C protein]		 CTD PMID:11835680 PMID:15975956 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdh1 cadherin 1 increases expression EXP Caffeine results in increased expression of CDH1 mRNA CTD PMID:20864626 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh11 cadherin 11 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CDH11 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CDH11 mRNA] CTD PMID:20230807 NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of CDK1 protein]; Caffeine results in decreased phosphorylation of and results in increased activity of CDK1 protein
Caffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]		 CTD PMID:9098629 PMID:11835680 PMID:15975956 PMID:19038232 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO Caffeine results in decreased activity of CDK2 protein CTD PMID:11835680 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression		 ISO Caffeine results in decreased activity of [CCND1 protein binds to CDK4 protein]
Caffeine results in decreased expression of CDK4 mRNA		 CTD PMID:11793227 PMID:15126379 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Cytarabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Decitabine results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [dorsomorphin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [entinostat results in increased expression of CDKN1A protein]; Caffeine inhibits the reaction [Oxaliplatin results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]		 CTD PMID:17977830 PMID:18223691 PMID:18347191 PMID:19735649 PMID:21840268 PMID:22927544 PMID:23274516 PMID:30555576 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A affects methylation ISO Caffeine affects the methylation of CDKN2A gene CTD PMID:30924039 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression
affects expression
increases expression		 EXP Caffeine results in decreased expression of CEBPA mRNA
Caffeine affects the expression of CEBPA mRNA
Caffeine results in increased expression of CEBPA mRNA		 CTD PMID:23727198 PMID:30423288 PMID:30528684 PMID:30776459 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression EXP Caffeine results in decreased expression of CEBPB mRNA CTD PMID:30528684 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CEMIP2 mRNA CTD PMID:28843594 NCBI chr 1:239,397,322...239,474,931
Ensembl chr 1:239,398,043...239,474,931 		JBrowse link
G Cetn3 centrin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CETN3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CETN3 mRNA] CTD PMID:20230807 NCBI chr 2:12,101,473...12,115,009
Ensembl chr 2:12,102,487...12,115,009
Ensembl chr 2:12,102,487...12,115,009 		JBrowse link
G Cfd complement factor D multiple interactions ISO [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
decreases expression
decreases phosphorylation		 ISO Caffeine inhibits the reaction [[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]; Caffeine inhibits the reaction [resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; xanthatin inhibits the reaction [Caffeine results in increased phosphorylation of CHEK1 protein]
Caffeine inhibits the reaction [Camptothecin results in increased expression of CHEK1 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased phosphorylation of CHEK1 protein]
Caffeine results in decreased expression of CHEK1 protein modified form
Caffeine results in decreased phosphorylation of CHEK1 protein		 CTD PMID:15975956 PMID:18158334 PMID:19261750 PMID:21505179 PMID:21561856 PMID:22403396 PMID:29074359 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
decreases activity		 ISO Caffeine inhibits the reaction [[Resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [dorsomorphin results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CHEK2 protein]; Caffeine inhibits the reaction [Resveratrol results in increased activity of [CHEK1 protein co-treated with CHEK2 protein]]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of CHEK2 protein]; Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
Caffeine results in decreased activity of CHEK2 protein		 CTD PMID:10531013 PMID:15975956 PMID:16777994 PMID:18158334 PMID:19038232 PMID:23274516 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CKMT1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CKMT1 mRNA] CTD PMID:20230807 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461 		JBrowse link
G Clic1 chloride intracellular channel 1 increases expression ISO Caffeine results in increased expression of CLIC1 protein CTD PMID:31195006 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166 		JBrowse link
G Clstn1 calsyntenin 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CLSTN1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CLSTN1 mRNA] CTD PMID:20230807 NCBI chr 5:166,533,262...166,601,686
Ensembl chr 5:166,533,181...166,601,684 		JBrowse link
G Cnn2 calponin 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CNN2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CNN2 mRNA] CTD PMID:20230807 NCBI chr 7:12,782,459...12,787,977
Ensembl chr 7:12,782,491...12,787,750 		JBrowse link
G Cobl cordon-bleu WH2 repeat protein affects expression EXP Caffeine affects the expression of COBL mRNA CTD PMID:20864626 NCBI chr14:92,341,949...92,497,169
Ensembl chr14:92,342,957...92,577,936 		JBrowse link
G Coch cochlin decreases expression EXP Caffeine results in decreased expression of COCH mRNA CTD PMID:20864626 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 ISO
EXP		 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COL1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of COL1A1 mRNA]
Caffeine results in decreased expression of COL1A1 mRNA		 CTD PMID:20230807 PMID:24275088 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Caffeine results in decreased expression of COL2A1 mRNA; Caffeine results in decreased expression of COL2A1 protein CTD PMID:29966748 PMID:32663519 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of COMT mRNA CTD PMID:29882086 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Coq8a coenzyme Q8A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COQ8A mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COQ8A mRNA] CTD PMID:20230807 NCBI chr13:98,451,629...98,480,438
Ensembl chr13:98,451,637...98,480,419 		JBrowse link
G Cort cortistatin decreases expression EXP Caffeine results in decreased expression of CORT protein CTD PMID:25868845 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Cox7a2l cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7A2L mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7A2L mRNA] CTD PMID:20230807 NCBI chr 6:6,695,807...6,709,790
Ensembl chr 6:6,695,827...6,709,783 		JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of COX7C mRNA] CTD PMID:20230807 NCBI chr 2:14,699,878...14,701,903
Ensembl chr 2:14,699,882...14,701,903 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Caffeine results in decreased expression of CPT1A mRNA CTD PMID:30776459 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO
EXP		 Caffeine results in decreased expression of CREB1 mRNA CTD PMID:26367767 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 decreases expression ISO Caffeine results in decreased expression of CRTC2 protein CTD PMID:31195006 NCBI chr 2:189,615,928...189,625,646
Ensembl chr 2:189,615,948...189,626,051 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 decreases expression EXP Caffeine results in decreased expression of CSNK2A2 mRNA CTD PMID:20864626 NCBI chr19:9,972,537...10,012,043
Ensembl chr19:9,972,537...10,012,043 		JBrowse link
G Cst3 cystatin C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CST3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of CST3 mRNA] CTD PMID:20230807 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions EXP [Isoproterenol co-treated with Caffeine] results in decreased expression of CTH mRNA CTD PMID:29447158 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis
multiple interactions		 EXP Caffeine results in increased mutagenesis of CTNNB1 gene
Caffeine inhibits the reaction [Doxorubicin results in decreased expression of CTNNB1 protein]		 CTD PMID:18283038 PMID:30377735 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Caffeine co-treated with Alprazolam] results in increased secretion of CTSB protein
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSB mRNA]		 CTD PMID:19490937 PMID:20230807 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Ctsd cathepsin D increases expression ISO Caffeine results in increased expression of CTSD protein CTD PMID:31195006 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Ctsl cathepsin L multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CTSL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CTSL mRNA] CTD PMID:20230807 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Cwc25 CWC25 spliceosome-associated protein homolog decreases expression ISO Caffeine results in decreased expression of CWC25 protein CTD PMID:31195006 NCBI chr10:85,684,898...85,709,568
Ensembl chr10:85,684,898...85,709,568 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of CXCL12 mRNA CTD PMID:28843594 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891 		JBrowse link
G Cyc1 cytochrome c-1 decreases expression ISO Caffeine results in decreased expression of CYC1 mRNA CTD PMID:11793227 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Caffeine inhibits the reaction [kaempferol affects the localization of CYCS protein] CTD PMID:19028473 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Caffeine results in decreased expression of CYP11A1 mRNA CTD PMID:24717552 PMID:25868845 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP Caffeine results in decreased expression of CYP11B1 mRNA CTD PMID:25868845 PMID:29343424 PMID:30528684 NCBI chr 7:116,248,759...116,255,205
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Caffeine results in decreased expression of CYP11B2 mRNA CTD PMID:25868845 PMID:29343424 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression EXP Caffeine results in increased expression of CYP17A1 mRNA CTD PMID:25868845 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP Caffeine results in increased expression of CYP19A1 mRNA; Caffeine results in increased expression of CYP19A1 protein CTD PMID:28111094 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Caffeine results in decreased activity of CYP1A1 protein CTD PMID:18420780 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
increases metabolic processing
decreases activity
affects metabolic processing
increases activity
decreases methylation		 ISO
EXP		 CYP1A2 protein binds to Caffeine
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of CYP1A2 mRNA
[CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,3,7-trimethyluric acid; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theobromine; [CYP1A2 protein binds to and results in increased metabolism of Caffeine] which results in increased chemical synthesis of Theophylline; [CYP1A2 protein results in increased metabolism of Caffeine] which results in increased chemical synthesis of 1,7-dimethylxanthine; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine]; CYP1A2 protein binds to and affects the metabolism of Caffeine; CYP1A2 protein binds to and results in increased metabolism of Caffeine; GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; Resveratrol promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]
Caffeine results in decreased activity of CYP1A2 protein
CYP1A2 protein affects the metabolism of Caffeine; CYP1A2 protein affects the metabolism of Caffeine metabolite
[Fluvoxamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Caffeine; Caffeine promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; CYP1A2 protein binds to and affects the metabolism of Caffeine
Caffeine results in increased activity of CYP1A2 protein		 CTD PMID:1302044 PMID:9334905 PMID:11145498 PMID:11376689 PMID:11465391 PMID:11907490 PMID:12433797 PMID:12706856 PMID:14586384 PMID:14586387 PMID:15022032 PMID:15199075 PMID:15286053 PMID:15327588 PMID:15619608 PMID:15659567 PMID:15822860 PMID:15856409 PMID:15980104 PMID:16934051 PMID:18420780 PMID:19215233 PMID:20716633 PMID:24211539 PMID:26599973 PMID:28843594 PMID:31132250 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Caffeine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 increases expression
decreases expression		 EXP Caffeine results in increased expression of CYP21A1 mRNA
Caffeine results in decreased expression of CYP21A1 mRNA		 CTD PMID:25868845 PMID:30528684 NCBI chr20:4,486,213...4,489,358
Ensembl chr20:4,486,219...4,489,550 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Caffeine CTD PMID:15199075 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing ISO CYP2E1 protein affects the metabolism of Caffeine CTD PMID:1302044 PMID:14586387 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Caffeine results in decreased activity of CYP3A4 protein CTD PMID:24211539 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression ISO Caffeine results in increased expression of CYP4B1 mRNA CTD PMID:18444173 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression EXP Caffeine results in decreased expression of CYP7B1 mRNA CTD PMID:20864626 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257 		JBrowse link
G Dad1 defender against cell death 1 decreases expression ISO Caffeine results in decreased expression of DAD1 mRNA CTD PMID:11793227 NCBI chr15:32,868,136...32,887,933
Ensembl chr15:32,868,087...32,888,095 		JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 decreases expression EXP Caffeine results in decreased expression of DCAF11 mRNA CTD PMID:20864626 NCBI chr15:34,233,840...34,244,512
Ensembl chr15:34,234,193...34,244,504 		JBrowse link
G Dct dopachrome tautomerase increases expression ISO Caffeine results in increased expression of DCT mRNA CTD PMID:18444173 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DCXR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of DCXR mRNA] CTD PMID:20230807 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715 		JBrowse link
G Ddhd1 DDHD domain containing 1 increases expression EXP Caffeine results in increased expression of DDHD1 mRNA CTD PMID:20864626 NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191 		JBrowse link
G Ddx31 DEAD-box helicase 31 decreases expression EXP Caffeine results in decreased expression of DDX31 mRNA CTD PMID:20864626 NCBI chr 3:7,422,871...7,488,299
Ensembl chr 3:7,422,820...7,488,617 		JBrowse link
G Ddx39a DExD-box helicase 39A decreases expression ISO Caffeine results in decreased expression of DDX39A protein CTD PMID:31195006 NCBI chr19:24,846,530...24,854,886
Ensembl chr19:24,846,938...24,854,953 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression EXP Caffeine results in decreased expression of DHCR24 mRNA CTD PMID:20864626 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP Caffeine results in decreased expression of DHCR7 mRNA CTD PMID:25868845 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904 		JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases expression EXP Caffeine results in increased expression of DHODH protein CTD PMID:6149265 NCBI chr19:42,066,103...42,087,906
Ensembl chr19:42,066,351...42,082,012 		JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DNAJA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJA1 mRNA] CTD PMID:20230807 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of DNAJB9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DNAJB9 mRNA] CTD PMID:20230807 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151 		JBrowse link
G Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 increases expression ISO Caffeine results in increased expression of DNAJC12 protein CTD PMID:31195006 NCBI chr20:26,893,139...26,913,041
Ensembl chr20:26,893,016...26,913,016 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression EXP Caffeine results in increased expression of DNMT1 mRNA CTD PMID:24717552 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression EXP Caffeine results in increased expression of DNMT3A mRNA CTD PMID:24717552 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta increases expression EXP Caffeine results in increased expression of DNMT3B mRNA CTD PMID:25868845 PMID:30423288 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of DPP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of DPP4 mRNA] CTD PMID:20230807 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672 		JBrowse link
G Drd2 dopamine receptor D2 affects response to substance
increases response to substance
multiple interactions		 ISO
EXP		 DRD2 polymorphism affects the susceptibility to Caffeine
DRD2 protein results in increased susceptibility to Caffeine
Caffeine inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine promotes the reaction [Spiperone binds to DRD2 protein]]		 CTD PMID:11172060 PMID:16889759 PMID:18305461 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 decreases expression EXP Caffeine results in decreased expression of DTX4 mRNA CTD PMID:20864626 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866 		JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression EXP Caffeine results in increased expression of DUSP8 mRNA CTD PMID:9813294 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460 		JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of E2F1 mRNA] CTD PMID:22403396 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression EXP Caffeine results in increased expression of EBP mRNA CTD PMID:25868845 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781 		JBrowse link
G Ebpl EBP like decreases expression EXP Caffeine results in decreased expression of EBPL mRNA CTD PMID:20864626 NCBI chr15:41,668,119...41,691,518
Ensembl chr15:41,668,119...41,691,518 		JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression EXP Caffeine results in decreased expression of ECI1 mRNA CTD PMID:20864626 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913 		JBrowse link
G Ecm1 extracellular matrix protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ECM1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ECM1 mRNA] CTD PMID:20230807 NCBI chr 2:197,855,468...197,860,973
Ensembl chr 2:197,855,460...197,860,699 		JBrowse link
G Edn1 endothelin 1 increases activity EXP Caffeine results in increased activity of EDN1 protein CTD PMID:1860718 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions
increases expression		 ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF1A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF1A1 mRNA]
Caffeine results in increased expression of EEF1A1 protein		 CTD PMID:20230807 PMID:31195006 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818 		JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta decreases expression ISO Caffeine results in decreased expression of EEF1D protein CTD PMID:31195006 NCBI chr 7:116,928,264...116,942,981
Ensembl chr 7:116,928,265...116,936,674 		JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma increases expression ISO Caffeine results in increased expression of EEF1G protein CTD PMID:31195006 NCBI chr 1:225,163,391...225,173,997
Ensembl chr 1:225,163,391...225,173,995 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EEF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EEF2 mRNA] CTD PMID:20230807 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771 		JBrowse link
G Efna1 ephrin A1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EFNA1 mRNA] CTD PMID:20230807 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222 		JBrowse link
G Efnb3 ephrin B3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EFNB3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EFNB3 mRNA] CTD PMID:20230807 NCBI chr10:56,161,431...56,168,819
Ensembl chr10:56,161,432...56,167,426 		JBrowse link
G Egr1 early growth response 1 increases expression
decreases expression
multiple interactions		 ISO
EXP		 Caffeine results in increased expression of EGR1 mRNA
Caffeine results in decreased expression of EGR1 mRNA
[Cocaine co-treated with Caffeine] results in increased expression of EGR1 mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of EGR1 mRNA]
[Caffeine co-treated with Dextroamphetamine] affects the expression of EGR1 mRNA		 CTD PMID:10971643 PMID:16771831 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Ehbp1 EH domain binding protein 1 increases expression ISO Caffeine results in increased expression of EHBP1 protein CTD PMID:31195006 NCBI chr14:106,871,426...107,160,224
Ensembl chr14:106,871,430...107,160,334 		JBrowse link
G Ehd1 EH-domain containing 1 decreases expression ISO Caffeine results in decreased expression of EHD1 protein CTD PMID:31195006 NCBI chr 1:221,644,867...221,667,242
Ensembl chr 1:221,644,867...221,667,239 		JBrowse link
G Ehd2 EH-domain containing 2 decreases expression ISO Caffeine results in decreased expression of EHD2 protein CTD PMID:31195006 NCBI chr 1:77,847,599...77,865,870
Ensembl chr 1:77,847,600...77,865,870 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression ISO Caffeine results in increased expression of EIF1 mRNA CTD PMID:11793227 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765 		JBrowse link
G Eif3b eukaryotic translation initiation factor 3, subunit B decreases expression ISO Caffeine results in decreased expression of EIF3B protein CTD PMID:31195006 NCBI chr12:16,285,730...16,310,190
Ensembl chr12:16,285,733...16,310,190 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of EIF4E mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EIF4E mRNA] CTD PMID:20230807 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
increases expression		 ISO
EXP		 Caffeine results in decreased expression of EIF4EBP1 protein modified form
Caffeine results in increased expression of EIF4EBP1 protein		 CTD PMID:21081844 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EIF5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of EIF5 mRNA] CTD PMID:20230807 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406 		JBrowse link
G Ell elongation factor for RNA polymerase II decreases expression EXP Caffeine results in decreased expression of ELL mRNA CTD PMID:20864626 NCBI chr16:20,594,129...20,641,441
Ensembl chr16:20,594,072...20,641,908 		JBrowse link
G Emc6 ER membrane protein complex subunit 6 decreases expression EXP Caffeine results in decreased expression of EMC6 mRNA CTD PMID:20864626 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315 		JBrowse link
G Endod1 endonuclease domain containing 1 decreases expression EXP Caffeine results in decreased expression of ENDOD1 mRNA CTD PMID:20864626 NCBI chr 8:12,898,430...12,928,156 JBrowse link
G Eno1 enolase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ENO1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ENO1 mRNA] CTD PMID:20230807 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609 		JBrowse link
G Eppk1 epiplakin 1 decreases expression ISO Caffeine results in decreased expression of EPPK1 protein CTD PMID:31195006 NCBI chr 7:117,163,383...117,173,741 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERN1 mRNA] CTD PMID:20230807 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of ERP44 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of ERP44 mRNA] CTD PMID:20230807 NCBI chr 5:63,937,866...64,030,827
Ensembl chr 5:63,937,784...64,030,901 		JBrowse link
G Esyt2 extended synaptotagmin 2 decreases expression EXP Caffeine results in decreased expression of ESYT2 mRNA CTD PMID:20864626 NCBI chr 6:144,156,021...144,248,374
Ensembl chr 6:144,156,175...144,245,545 		JBrowse link
G Etv3 ETS variant transcription factor 3 increases expression ISO Caffeine results in increased expression of ETV3 protein CTD PMID:31195006 NCBI chr 2:186,872,483...186,887,294
Ensembl chr 2:186,872,520...186,886,592 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Caffeine results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142 		JBrowse link
G Ezr ezrin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of EZR mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of EZR mRNA] CTD PMID:20230807 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO
EXP		 Caffeine results in decreased expression of FABP4 mRNA CTD PMID:23727198 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Farsa phenylalanyl-tRNA synthetase subunit alpha increases expression ISO Caffeine results in increased expression of FARSA protein CTD PMID:31195006 NCBI chr19:25,969,255...25,978,777
Ensembl chr19:25,969,255...25,978,776 		JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP Caffeine results in decreased expression of FAS mRNA CTD PMID:29343424 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fasn fatty acid synthase multiple interactions
increases expression		 ISO
EXP		 [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of FASN mRNA
Caffeine results in increased expression of FASN mRNA; Caffeine results in increased expression of FASN protein		 CTD PMID:28843594 PMID:30776459 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fastkd3 FAST kinase domains 3 decreases expression EXP Caffeine results in decreased expression of FASTKD3 mRNA CTD PMID:20864626 NCBI chr 1:37,734,400...37,742,932
Ensembl chr 1:37,734,403...37,742,932 		JBrowse link
G Fau FAU, ubiquitin like and ribosomal protein S30 fusion increases expression ISO Caffeine results in increased expression of FAU protein CTD PMID:31195006 NCBI chr 1:221,420,312...221,421,827
Ensembl chr 1:221,420,271...221,421,842
Ensembl chr 6:221,420,271...221,421,842 		JBrowse link
G Fbln2 fibulin 2 increases expression EXP Caffeine results in increased expression of FBLN2 mRNA CTD PMID:20864626 NCBI chr 4:122,835,237...122,895,127
Ensembl chr 4:122,835,436...122,895,121 		JBrowse link
G Fbrs fibrosin increases expression EXP Caffeine results in increased expression of FBRS mRNA CTD PMID:20864626 NCBI chr 1:198,925,265...198,938,939
Ensembl chr 1:198,932,870...198,937,750 		JBrowse link
G Fbxl12 F-box and leucine-rich repeat protein 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of FBXL12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FBXL12 mRNA] CTD PMID:20230807 NCBI chr 8:21,656,636...21,662,755
Ensembl chr 8:21,656,639...21,661,259 		JBrowse link
G Fbxl19 F-box and leucine-rich repeat protein 19 decreases expression ISO Caffeine results in decreased expression of FBXL19 protein CTD PMID:31195006 NCBI chr 1:199,196,126...199,217,147
Ensembl chr 1:199,196,059...199,216,391 		JBrowse link
G Fcsk fucose kinase increases expression EXP Caffeine results in increased expression of FCSK mRNA CTD PMID:20864626 NCBI chr19:43,338,146...43,357,826
Ensembl chr19:43,338,166...43,357,822 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 decreases expression
increases expression		 EXP Caffeine results in decreased expression of FDFT1 mRNA
Caffeine results in increased expression of FDFT1 mRNA		 CTD PMID:20864626 PMID:25868845 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302 		JBrowse link
G Fdx1 ferredoxin 1 decreases expression EXP Caffeine results in decreased expression of FDX1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr 8:56,373,729...56,393,199
Ensembl chr 8:56,373,723...56,393,233 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Caffeine results in increased expression of FHL1 mRNA CTD PMID:20864626 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524 		JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression EXP Caffeine results in increased expression of FILIP1L mRNA CTD PMID:20864626 NCBI chr11:45,039,488...45,275,141
Ensembl chr11:45,039,461...45,124,423 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO Caffeine results in increased expression of FOS mRNA
[Cocaine co-treated with Caffeine] results in increased expression of FOS mRNA; Cocaine promotes the reaction [Caffeine results in increased expression of FOS mRNA]		 CTD PMID:10971643 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of FYN mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of FYN mRNA] CTD PMID:20230807 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317 		JBrowse link
G Gale UDP-galactose-4-epimerase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GALE mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GALE mRNA] CTD PMID:20230807 NCBI chr 5:154,310,453...154,314,959
Ensembl chr 5:154,310,453...154,314,955 		JBrowse link
G Ganab glucosidase II alpha subunit decreases expression ISO Caffeine results in decreased expression of GANAB protein CTD PMID:31195006 NCBI chr 1:225,096,558...225,116,384
Ensembl chr 1:225,096,598...225,116,378 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GAPDH mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GAPDH mRNA] CTD PMID:20230807 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962 		JBrowse link
G Gast gastrin increases secretion EXP Caffeine results in increased secretion of GAST protein CTD PMID:19208342 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GCLC mRNA CTD PMID:28843594 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gdf10 growth differentiation factor 10 decreases expression EXP Caffeine results in decreased expression of GDF10 mRNA CTD PMID:20864626 NCBI chr16:10,250,508...10,262,383
Ensembl chr16:10,250,404...10,263,150 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO
EXP		 Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFAP protein]
Caffeine inhibits the reaction [aluminum chloride results in increased expression of GFAP protein]		 CTD PMID:19882200 PMID:26339337 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Gh1 growth hormone 1 multiple interactions ISO GH1 protein promotes the reaction [CYP1A2 protein results in increased metabolism of Caffeine] CTD PMID:11907490 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180 		JBrowse link
G Ghitm growth hormone inducible transmembrane protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GHITM mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GHITM mRNA] CTD PMID:20230807 NCBI chr16:14,370,269...14,382,647
Ensembl chr16:14,371,531...14,382,641 		JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Caffeine results in decreased expression of GJA1 mRNA CTD PMID:28087314 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Glrx glutaredoxin decreases expression ISO Caffeine results in decreased expression of GLRX mRNA CTD PMID:11793227 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944 		JBrowse link
G Glt8d1 glycosyltransferase 8 domain containing 1 decreases expression ISO Caffeine results in decreased expression of GLT8D1 mRNA CTD PMID:11793227 NCBI chr16:7,082,450...7,097,405
Ensembl chr16:7,082,450...7,097,401 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO Caffeine results in decreased expression of GLUD1 mRNA CTD PMID:11793227 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557 		JBrowse link
G Gmfb glia maturation factor, beta multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GMFB mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GMFB mRNA] CTD PMID:20230807 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression
increases expression		 EXP Caffeine results in decreased expression of GNAI1 protein
Caffeine results in increased expression of GNAI1 mRNA		 CTD PMID:15708489 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Caffeine results in decreased expression of GNAI2 protein CTD PMID:15708489 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Gnal G protein subunit alpha L increases response to substance ISO GNAL protein results in increased susceptibility to Caffeine CTD PMID:11404425 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630 		JBrowse link
G Gnaq G protein subunit alpha q decreases expression EXP Caffeine results in decreased expression of GNAQ protein CTD PMID:15998294 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786 		JBrowse link
G Gnas GNAS complex locus decreases expression EXP Caffeine results in decreased expression of GNAS protein CTD PMID:15708489 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Golt1b golgi transport 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GOLT1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GOLT1B mRNA] CTD PMID:20230807 NCBI chr 4:176,606,669...176,617,884
Ensembl chr 4:176,606,649...176,619,710 		JBrowse link
G Gosr1 golgi SNAP receptor complex member 1 decreases expression EXP Caffeine results in decreased expression of GOSR1 mRNA CTD PMID:20864626 NCBI chr10:63,405,526...63,442,257
Ensembl chr10:63,405,586...63,442,250 		JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 decreases expression ISO Caffeine results in decreased expression of GOT2 protein CTD PMID:31195006 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340 		JBrowse link
G Gpc3 glypican 3 affects expression EXP Caffeine affects the expression of GPC3 mRNA CTD PMID:20864626 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883 		JBrowse link
G Gpi glucose-6-phosphate isomerase decreases expression ISO Caffeine results in decreased expression of GPI protein CTD PMID:31195006 NCBI chr 1:90,063,411...90,091,287
Ensembl chr 1:90,063,411...90,091,287 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity		 EXP Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]; fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Caffeine results in increased activity of GPT protein		 CTD PMID:11394713 PMID:30776459 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Caffeine promotes the reaction [bisphenol A results in decreased expression of GPX1 mRNA] CTD PMID:31756439 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GPX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GPX3 mRNA] CTD PMID:20230807 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of GPX4 mRNA CTD PMID:31756439 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GRID2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GRID2 mRNA] CTD PMID:20230807 NCBI chr 4:94,068,112...95,476,864
Ensembl chr 4:94,696,965...95,442,778 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 decreases expression EXP Caffeine results in decreased expression of GRM1 protein CTD PMID:15998294 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859 		JBrowse link
G Grpr gastrin releasing peptide receptor decreases expression EXP Caffeine results in decreased expression of GRPR mRNA CTD PMID:20864626 NCBI chr  X:32,746,259...32,786,266
Ensembl chr  X:32,745,873...32,786,359 		JBrowse link
G Grwd1 glutamate-rich WD repeat containing 1 decreases expression EXP Caffeine results in decreased expression of GRWD1 mRNA CTD PMID:20864626 NCBI chr 1:101,813,356...101,819,058
Ensembl chr 1:101,813,684...101,819,478 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression EXP Caffeine results in increased expression of GSK3A mRNA CTD PMID:25868845 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
decreases phosphorylation
multiple interactions		 ISO Caffeine results in increased phosphorylation of GSK3B protein
Caffeine results in decreased phosphorylation of GSK3B protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein]		 CTD PMID:15126379 PMID:21229324 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of GSR mRNA CTD PMID:28843594 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 decreases expression ISO Caffeine results in decreased expression of GSTO1 mRNA CTD PMID:11793227 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387 		JBrowse link
G H1f0 H1.0 linker histone decreases expression ISO Caffeine results in decreased expression of H1F0 protein CTD PMID:31195006 NCBI chr 7:120,260,776...120,262,636 JBrowse link
G H1f4 H1.4 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-4 protein CTD PMID:31195006 NCBI chr17:43,734,461...43,735,120
Ensembl chr17:43,734,461...43,735,120 		JBrowse link
G H1f5 H1.5 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-5 protein CTD PMID:31195006 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981 		JBrowse link
G H1f6 H1.6 linker histone, cluster member increases expression ISO Caffeine results in increased expression of H1-6 protein CTD PMID:31195006 NCBI chr17:43,675,190...43,675,934
Ensembl chr17:43,675,190...43,675,934 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO
EXP		 Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AX protein]; Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein]; Caffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]
[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein		 CTD PMID:15537744 PMID:15975956 PMID:16777994 PMID:20888899 PMID:24069304 PMID:26231820 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hacd1 3-hydroxyacyl-CoA dehydratase 1 decreases expression EXP Caffeine results in decreased expression of HACD1 mRNA CTD PMID:20864626 NCBI chr17:81,173,238...81,196,012
Ensembl chr17:81,173,713...81,187,739 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HBA-A1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HBA-A1 mRNA] CTD PMID:20230807 NCBI chr10:15,602,794...15,603,649
Ensembl chr10:15,602,794...15,603,649 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP Caffeine results in increased expression of HDAC1 mRNA CTD PMID:24717552 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723 		JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP Caffeine results in increased expression of HDAC2 mRNA CTD PMID:24717552 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198 		JBrowse link
G Hdac7 histone deacetylase 7 increases expression EXP Caffeine results in increased expression of HDAC7 mRNA; Caffeine results in increased expression of HDAC7 protein CTD PMID:31306741 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455 		JBrowse link
G Hdlbp high density lipoprotein binding protein decreases expression EXP Caffeine results in decreased expression of HDLBP mRNA CTD PMID:25868845 NCBI chr 9:100,554,574...100,624,707
Ensembl chr 9:100,554,563...100,624,638 		JBrowse link
G Heca hdc homolog, cell cycle regulator increases expression EXP Caffeine results in increased expression of HECA mRNA CTD PMID:20864626 NCBI chr 1:13,036,909...13,050,644
Ensembl chr 1:13,036,909...13,050,644 		JBrowse link
G Hells helicase, lymphoid specific multiple interactions
increases expression		 ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HELLS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HELLS mRNA]
Caffeine results in increased expression of HELLS protein		 CTD PMID:20025956 PMID:20230807 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183 		JBrowse link
G Hhipl2 HHIP like 2 decreases expression ISO Caffeine results in decreased expression of HHIPL2 protein CTD PMID:31195006 NCBI chr13:101,814,574...101,835,144
Ensembl chr13:101,814,574...101,834,584 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of HIF1A mRNA CTD PMID:31756439 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HINT1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HINT1 mRNA] CTD PMID:20230807 NCBI chr10:40,208,236...40,211,981
Ensembl chr10:40,208,223...40,211,975 		JBrowse link
G Hist1h4b histone cluster 1 H4 family member B increases expression ISO Caffeine results in increased expression of H4C9 protein CTD PMID:31195006 NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583 		JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO Caffeine results in decreased expression of HMGA1 protein CTD PMID:31195006 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980 		JBrowse link
G Hmga2 high mobility group AT-hook 2 decreases expression ISO Caffeine results in decreased expression of HMGA2 protein CTD PMID:31195006 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408 		JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO Caffeine results in decreased expression of HMGB1 protein CTD PMID:31195006 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression		 EXP
ISO		 [Dietary Fats co-treated with Caffeine] results in decreased expression of HMGCR mRNA; Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of HMGCR mRNA]
Caffeine results in increased expression of HMGCR mRNA; Caffeine results in increased expression of HMGCR protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCR mRNA]		 CTD PMID:29800656 PMID:29958987 PMID:30825513 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Caffeine results in decreased expression of HMGCS1 mRNA
Caffeine results in increased expression of HMGCS1 mRNA
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of HMGCS1 mRNA]		 CTD PMID:20864626 PMID:25868845 PMID:30825513 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 decreases expression ISO Caffeine results in decreased expression of HNRNPA1 protein CTD PMID:31195006 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HNRNPC mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HNRNPC mRNA] CTD PMID:20230807 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Caffeine results in decreased expression of HNRNPDL protein CTD PMID:31195006 NCBI chr14:11,199,114...11,204,670
Ensembl chr14:11,198,896...11,202,669 		JBrowse link
G Hnrnpf heterogeneous nuclear ribonucleoprotein F decreases expression ISO Caffeine results in decreased expression of HNRNPF protein CTD PMID:31195006 NCBI chr 4:149,957,143...149,978,896
Ensembl chr 4:149,957,206...149,978,895 		JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 decreases expression ISO Caffeine results in decreased expression of HNRNPH1 protein CTD PMID:31195006 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K decreases expression
increases expression		 EXP
ISO		 Caffeine results in decreased expression of HNRNPK mRNA
Caffeine results in increased expression of HNRNPK protein		 CTD PMID:25868845 PMID:31195006 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Caffeine results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP Caffeine results in increased expression of HPRT1 protein CTD PMID:6149265 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of HRAS mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HRAS mRNA] CTD PMID:20230807 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Caffeine results in increased expression of HSD11B1 mRNA CTD PMID:22583948 PMID:30423288 PMID:30528684 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression
multiple interactions		 EXP
ISO		 Caffeine results in decreased expression of HSD11B2 mRNA
ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]; Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein; Colforsin inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein]; Colforsin inhibits the reaction [Caffeine results in decreased expression of HSD11B2 mRNA]		 CTD PMID:22583948 PMID:22701600 PMID:30423288 PMID:30528684 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP Caffeine results in decreased expression of HSD17B7 mRNA CTD PMID:20864626 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
decreases expression		 EXP Caffeine results in increased expression of HSD3B1 mRNA
Caffeine results in decreased expression of HSD3B1 mRNA		 CTD PMID:25868845 PMID:30528684
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HSP90AA1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSP90AA1 mRNA] CTD PMID:20230807 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Caffeine results in decreased expression of HSP90B1 mRNA CTD PMID:25868845 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression ISO Caffeine results in increased expression of HSPA4 protein CTD PMID:31195006 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO Caffeine results in decreased expression of HSPA9 protein CTD PMID:31195006 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression
decreases expression		 EXP
ISO		 Caffeine results in increased expression of HSPB1 mRNA
Caffeine results in decreased expression of HSPB1 protein		 CTD PMID:20864626 PMID:31195006 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 increases expression EXP Caffeine results in increased expression of HSPB6 mRNA CTD PMID:20864626 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions ISO Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of HSPE1 mRNA] CTD PMID:20230807 NCBI chr 9:61,691,246...61,724,948
Ensembl chr 9:61,692,154...61,694,599 		JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression EXP Caffeine results in decreased expression of IBSP mRNA CTD PMID:31874197 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Caffeine results in decreased expression of ICAM1 mRNA CTD PMID:28089782 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression EXP Caffeine results in increased expression of ID3 mRNA CTD PMID:20864626 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression EXP Caffeine results in decreased expression of IDI1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases secretion
multiple interactions
affects expression
decreases activity
decreases expression		 ISO
EXP		 Caffeine results in decreased secretion of IGF1 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of IGF1 mRNA
Caffeine affects the expression of IGF1 protein
Caffeine results in decreased activity of IGF1 protein
Caffeine results in decreased expression of IGF1 mRNA; Caffeine results in decreased expression of IGF1 protein		 CTD PMID:1995187 PMID:22583948 PMID:24239806 PMID:29343424 PMID:29966748 PMID:30528684 PMID:31756439 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression
affects expression		 EXP Caffeine results in decreased expression of IGF1R mRNA; Caffeine results in decreased expression of IGF1R protein
Caffeine affects the expression of IGF1R mRNA		 CTD PMID:22583948 PMID:29343424 PMID:29966748 PMID:30528684 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Caffeine results in increased expression of IGFBP1 mRNA CTD PMID:11793227 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta increases expression EXP Caffeine results in increased expression of IKBKB mRNA CTD PMID:20864626 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il10 interleukin 10 increases expression ISO Caffeine results in increased expression of IL10 mRNA CTD PMID:28089782 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression EXP Caffeine results in increased expression of IL10RB mRNA CTD PMID:20864626 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457 		JBrowse link
G Il12a interleukin 12A decreases expression ISO Caffeine results in decreased expression of IL12A mRNA CTD PMID:28089782 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:26852703 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression		 ISO
EXP		 Caffeine results in decreased expression of IL1B mRNA
Caffeine results in increased expression of IL1B mRNA		 CTD PMID:28089782 PMID:29055810 PMID:30776459 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Caffeine results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170 		JBrowse link
G Il3 interleukin 3 multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL3 mRNA] CTD PMID:26852703 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973 		JBrowse link
G Il4r interleukin 4 receptor increases expression
multiple interactions		 EXP
ISO		 Caffeine results in increased expression of IL4RA mRNA
[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IL4RA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL4RA mRNA]		 CTD PMID:20230807 PMID:20864626 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220 		JBrowse link
G Il5 interleukin 5 increases expression ISO Caffeine results in increased expression of IL5 mRNA CTD PMID:28089782 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Caffeine results in decreased expression of IL6 mRNA
Caffeine results in increased expression of IL6 mRNA
Caffeine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]		 CTD PMID:23727198 PMID:26852703 PMID:29055810 PMID:30776459 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 increases expression ISO Caffeine results in increased expression of ILF3 protein CTD PMID:31195006 NCBI chr 8:22,402,877...22,440,984
Ensembl chr 8:22,402,890...22,440,885 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of IMPDH2 protein CTD PMID:31195006 NCBI chr 8:117,346,983...117,351,619
Ensembl chr 8:117,347,029...117,351,610 		JBrowse link
G Ino80c INO80 complex subunit C decreases expression EXP Caffeine results in decreased expression of INO80C mRNA CTD PMID:20864626 NCBI chr18:15,995,005...16,009,639
Ensembl chr18:15,995,000...16,009,710 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP Caffeine results in decreased expression of INSIG1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515 		JBrowse link
G Insr insulin receptor decreases expression EXP Caffeine results in decreased expression of INSR mRNA CTD PMID:22583948 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRAK1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IRAK1 mRNA] CTD PMID:20230807 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977 		JBrowse link
G Irx3 iroquois homeobox 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of IRX3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of IRX3 mRNA] CTD PMID:20230807 NCBI chr19:15,838,714...15,842,135
Ensembl chr19:15,838,714...15,840,990 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Caffeine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ITGAM protein] CTD PMID:19882200 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Itm2b integral membrane protein 2B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of ITM2B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of ITM2B mRNA] CTD PMID:20230807 NCBI chr15:55,254,703...55,277,713
Ensembl chr15:55,254,706...55,277,713 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO Caffeine results in decreased expression of ITPR1 mRNA CTD PMID:18444173 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases phosphorylation
increases expression		 ISO Caffeine results in decreased phosphorylation of JUN protein
Caffeine results in increased expression of JUN protein		 CTD PMID:17145898 PMID:20025956 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kctd14 potassium channel tetramerization domain containing 14 decreases expression EXP Caffeine results in decreased expression of KCTD14 mRNA CTD PMID:20864626 NCBI chr 1:162,418,389...162,424,322
Ensembl chr 1:162,419,262...162,424,825 		JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression ISO Caffeine results in increased expression of KHSRP protein CTD PMID:31195006 NCBI chr 9:10,013,795...10,023,670
Ensembl chr 9:10,013,854...10,022,924 		JBrowse link
G Kidins220 kinase D-interacting substrate 220 increases expression EXP Caffeine results in increased expression of KIDINS220 mRNA CTD PMID:20864626 NCBI chr 6:44,225,142...44,322,938
Ensembl chr 6:44,225,233...44,322,938 		JBrowse link
G Kif3b kinesin family member 3B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KIF3B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of KIF3B mRNA] CTD PMID:20230807 NCBI chr 3:148,772,937...148,813,342
Ensembl chr 3:148,773,259...148,813,293 		JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression		 ISO
EXP		 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of KLF4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KLF4 mRNA]
Caffeine results in decreased expression of KLF4 mRNA; Caffeine results in decreased expression of KLF4 protein		 CTD PMID:20230807 PMID:31306741 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669 		JBrowse link
G Krt1 keratin 1 decreases expression ISO Caffeine results in decreased expression of KRT1 protein CTD PMID:31195006 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544 		JBrowse link
G Krt18 keratin 18 decreases expression ISO Caffeine results in decreased expression of KRT18 protein CTD PMID:31195006 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131 		JBrowse link
G Krt36 keratin 36 decreases expression ISO Caffeine results in decreased expression of KRT36 protein CTD PMID:31195006 NCBI chr10:88,016,602...88,019,967
Ensembl chr10:88,016,602...88,019,967 		JBrowse link
G Krt84 keratin 84 decreases expression ISO Caffeine results in decreased expression of KRT84 protein CTD PMID:31195006 NCBI chr 7:143,180,212...143,187,684
Ensembl chr 7:143,179,835...143,187,648 		JBrowse link
G Lamb1 laminin subunit beta 1 increases expression ISO Caffeine results in increased expression of LAMB1 protein CTD PMID:31195006 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Caffeine results in decreased expression of LDHA mRNA CTD PMID:11793227 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions EXP [Caffeine co-treated with Dietary Fats] results in decreased expression of LDLR mRNA; Caffeine promotes the reaction [Dietary Fats results in decreased expression of LDLR mRNA] CTD PMID:29800656 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903 		JBrowse link
G Lep leptin decreases expression
multiple interactions		 ISO
EXP		 Caffeine results in decreased expression of LEP mRNA
Caffeine results in decreased expression of LEP mRNA; Caffeine results in decreased expression of LEP protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of LEP mRNA]		 CTD PMID:23727198 PMID:26367767 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lepr leptin receptor increases expression
decreases expression		 EXP Caffeine results in increased expression of LEPR mRNA
Caffeine results in decreased expression of LEPR mRNA		 CTD PMID:22583948 PMID:26367767 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Caffeine results in decreased expression of LMNB1 protein CTD PMID:31195006 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264 		JBrowse link
G LOC100361854 ribosomal protein S26-like increases expression ISO Caffeine results in increased expression of RPS26 protein CTD PMID:31195006 NCBI chr  X:115,495,660...115,496,062
Ensembl chr  X:115,495,698...115,496,045 		JBrowse link
G Lpar4 lysophosphatidic acid receptor 4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of LPAR4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of LPAR4 mRNA] CTD PMID:20230807 NCBI chr  X:78,042,859...78,056,347
Ensembl chr  X:78,042,859...78,056,347 		JBrowse link
G Lpl lipoprotein lipase decreases expression
multiple interactions		 EXP
ISO		 Caffeine results in decreased expression of LPL mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of LPL mRNA		 CTD PMID:23727198 PMID:28843594 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Lss lanosterol synthase multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of LSS mRNA CTD PMID:28843594 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497 		JBrowse link
G Lysmd2 LysM domain containing 2 decreases expression EXP Caffeine results in decreased expression of LYSMD2 mRNA CTD PMID:20864626 NCBI chr 8:82,560,363...82,576,662
Ensembl chr 8:82,560,761...82,577,019 		JBrowse link
G Mael maelstrom spermatogenic transposon silencer decreases expression ISO Caffeine results in decreased expression of MAEL protein CTD PMID:31195006 NCBI chr13:84,412,569...84,452,140
Ensembl chr13:84,383,670...84,452,181 		JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAOA mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAOA mRNA] CTD PMID:20230807 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases cleavage
multiple interactions		 ISO Caffeine results in increased cleavage of MAP1LC3B protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; Sirolimus promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]		 CTD PMID:30555576 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MAP2K7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP2K7 mRNA] CTD PMID:20230807 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MAP3K12 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MAP3K12 mRNA] CTD PMID:20230807 NCBI chr 7:144,102,275...144,120,306
Ensembl chr 7:144,102,680...144,109,116 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
decreases phosphorylation		 ISO Caffeine results in increased expression of MAPK1 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Caffeine results in decreased phosphorylation of MAPK1 protein		 CTD PMID:17145898 PMID:21081844 PMID:22974838 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk15 mitogen-activated protein kinase 15 increases expression EXP Caffeine results in increased expression of MAPK15 mRNA CTD PMID:20864626 NCBI chr 7:117,041,287...117,061,799
Ensembl chr 7:117,055,395...117,061,047 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
decreases phosphorylation		 ISO Caffeine results in increased expression of MAPK3 protein modified form
Caffeine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Caffeine results in decreased phosphorylation of MAPK3 protein		 CTD PMID:17145898 PMID:21081844 PMID:22974838 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Marchf11 membrane associated ring-CH-type finger 11 decreases expression EXP Caffeine results in decreased expression of MARCHF11 mRNA CTD PMID:20864626 NCBI chr 2:78,825,053...78,926,402
Ensembl chr 2:78,825,074...78,926,395 		JBrowse link
G Mc2r melanocortin 2 receptor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MC2R mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MC2R mRNA] CTD PMID:20230807 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Caffeine results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201 		JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO Caffeine results in decreased expression of MDH2 protein CTD PMID:31195006 NCBI chr12:23,941,451...23,954,406
Ensembl chr12:23,941,448...23,954,431 		JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression
multiple interactions		 EXP Caffeine results in increased expression of MEF2A mRNA; Caffeine results in increased expression of MEF2A protein
Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]		 CTD PMID:25093688 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263 		JBrowse link
G Mef2c myocyte enhancer factor 2C multiple interactions
increases expression		 EXP Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2C protein]
Caffeine results in increased expression of MEF2C mRNA; Caffeine results in increased expression of MEF2C protein		 CTD PMID:25093688 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases expression ISO Caffeine results in decreased expression of MGST1 mRNA CTD PMID:11793227 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
G Micb MHC class I polypeptide-related sequence B multiple interactions ISO Caffeine inhibits the reaction [[Decitabine results in decreased methylation of MICB promoter] which results in increased expression of MICB protein] CTD PMID:18395517 NCBI chr 1:79,754,587...79,772,092
Ensembl chr 1:79,754,587...79,772,092 		JBrowse link
G Mill1 MHC I like leukocyte 1 multiple interactions ISO Caffeine inhibits the reaction [Resveratrol results in increased expression of MICA protein] CTD PMID:23445485 NCBI chr 1:79,631,266...79,657,943
Ensembl chr 1:79,631,668...79,657,941 		JBrowse link
G Mir101a microRNA 101a multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR101A mRNA CTD PMID:28843594 NCBI chr 5:120,168,437...120,168,511
Ensembl chr 5:120,168,433...120,168,515 		JBrowse link
G Mir122 microRNA 122 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] affects the expression of MIR122 mRNA CTD PMID:28843594 NCBI chr18:60,755,285...60,755,369 JBrowse link
G Mir192 microRNA 192 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of MIR192 mRNA CTD PMID:28843594 NCBI chr 1:221,634,971...221,635,080
Ensembl chr 1:221,634,971...221,635,080 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression		 EXP Caffeine inhibits the reaction [aluminum chloride results in decreased expression of MKI67 protein]
Caffeine results in decreased expression of MKI67 protein		 CTD PMID:26339337 PMID:30528684 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of MLXIPL mRNA CTD PMID:28843594 NCBI chr12:24,590,645...24,619,639 JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP Caffeine results in increased expression of MMP13 mRNA CTD PMID:31874197 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA] CTD PMID:20230807 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049 		JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 decreases expression EXP Caffeine results in decreased expression of MOGAT1 mRNA CTD PMID:20864626 NCBI chr 9:84,405,481...84,418,657
Ensembl chr 9:84,405,477...84,418,591 		JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression ISO Caffeine results in increased expression of MOS protein CTD PMID:31195006 NCBI chr 5:16,746,085...16,747,392
Ensembl chr 5:16,746,197...16,747,222 		JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression EXP Caffeine results in decreased expression of MRM3 mRNA CTD PMID:20864626 NCBI chr10:64,398,308...64,406,193
Ensembl chr10:64,398,339...64,405,017 		JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 decreases expression EXP Caffeine results in decreased expression of MRPL19 mRNA CTD PMID:20864626 NCBI chr 4:112,703,041...112,707,270
Ensembl chr 4:112,703,041...112,707,270 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL20 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of MRPL20 mRNA] CTD PMID:20230807 NCBI chr 5:173,248,245...173,252,775
Ensembl chr 5:173,248,245...173,252,775 		JBrowse link
G mrpl9 mitochondrial ribosomal protein L9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MRPL9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MRPL9 mRNA] CTD PMID:20230807 NCBI chr 2:195,684,750...195,689,470
Ensembl chr 2:195,684,210...195,689,052 		JBrowse link
G Mrps5 mitochondrial ribosomal protein S5 increases expression ISO Caffeine results in increased expression of MRPS5 protein CTD PMID:31195006 NCBI chr 3:120,165,953...120,182,536
Ensembl chr 3:120,165,913...120,182,536 		JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Caffeine results in decreased expression of MSH2 mRNA CTD PMID:12706856 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression EXP Caffeine results in decreased expression of MSMO1 mRNA CTD PMID:20864626 PMID:25868845 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MT2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MT2 mRNA] CTD PMID:20230807 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Mtch1 mitochondrial carrier 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTCH1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTCH1 mRNA] CTD PMID:20230807 NCBI chr20:6,937,341...6,961,165
Ensembl chr20:6,937,347...6,961,162 		JBrowse link
G Mtf2 metal response element binding transcription factor 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of MTF2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MTF2 mRNA] CTD PMID:20230807 NCBI chr14:2,656,776...2,701,027
Ensembl chr14:2,658,267...2,700,977 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like decreases expression EXP Caffeine results in decreased expression of MTHFD2L mRNA CTD PMID:20864626 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases activity ISO Caffeine results in decreased activity of MTOR protein CTD PMID:21081844 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase decreases expression EXP Caffeine results in decreased expression of MTRR mRNA CTD PMID:20864626 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015 		JBrowse link
G Mutyh mutY DNA glycosylase increases expression EXP Caffeine results in increased expression of MUTYH mRNA CTD PMID:20864626 NCBI chr 5:135,663,328...135,675,348
Ensembl chr 5:135,663,371...135,675,344 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression EXP Caffeine results in decreased expression of MVD mRNA CTD PMID:25868845 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951 		JBrowse link
G Mvk mevalonate kinase increases expression EXP Caffeine results in increased expression of MVK mRNA CTD PMID:25868845 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Caffeine promotes the reaction [[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dietary Fats] results in increased expression of MYC mRNA] CTD PMID:18283038 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myh7 myosin heavy chain 7 increases expression
multiple interactions		 EXP Caffeine results in increased expression of MYH7 mRNA
Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Curcumin promotes the reaction [KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]; Cyclosporine inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; Dantrolene inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]; KN 93 promotes the reaction [Curcumin inhibits the reaction [Caffeine results in increased expression of MYH7 mRNA]]		 CTD PMID:25093688 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Myl6b myosin light chain 6B decreases expression ISO Caffeine results in decreased expression of MYL6B protein CTD PMID:31195006 NCBI chr  X:43,831,778...43,833,044 JBrowse link
G Myof myoferlin increases expression ISO Caffeine results in increased expression of MYOF protein CTD PMID:31195006 NCBI chr 1:256,585,410...256,734,727
Ensembl chr 1:256,585,410...256,734,730 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects metabolic processing		 ISO NAT2 protein results in increased acetylation of Caffeine
NAT2 gene polymorphism affects the metabolism of Caffeine; NAT2 protein affects the metabolism of Caffeine		 CTD PMID:14586384 PMID:14586387 PMID:14747882 PMID:15199075 PMID:15327588 PMID:15558239 PMID:15980104 PMID:24221535 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570 		JBrowse link
G Ncl nucleolin increases expression ISO Caffeine results in increased expression of NCL protein CTD PMID:31195006 NCBI chr 9:93,369,119...93,377,643
Ensembl chr 9:93,368,932...93,377,643 		JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NDUFB5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFB5 mRNA] CTD PMID:20230807 NCBI chr 2:119,139,717...119,153,753
Ensembl chr 2:119,139,717...119,153,753 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NDUFS4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NDUFS4 mRNA] CTD PMID:20230807 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Caffeine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Caffeine results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:22974838 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of NFKBIA protein] CTD PMID:26852703 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nisch nischarin multiple interactions EXP Caffeine inhibits the reaction [[moxonidine binds to and results in increased activity of NISCH protein] which results in decreased susceptibility to Ethanol] CTD PMID:22613216 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22974838 PMID:26852703 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP [Isoproterenol co-treated with Caffeine] results in decreased expression of NOS3 mRNA CTD PMID:29447158 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin decreases expression EXP Caffeine results in decreased expression of NPHS1 mRNA; Caffeine results in decreased expression of NPHS1 protein CTD PMID:25986755 PMID:31306741 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin decreases expression EXP Caffeine results in decreased expression of NPHS2 mRNA CTD PMID:25986755 PMID:31306741 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522 		JBrowse link
G Npl N-acetylneuraminate pyruvate lyase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of NPL mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NPL mRNA] CTD PMID:20230807 NCBI chr13:70,938,073...70,981,179
Ensembl chr13:70,938,082...70,980,913 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP Caffeine analog inhibits the reaction [2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]]; Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPA mRNA] CTD PMID:15452191 PMID:25093688 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nppb natriuretic peptide B increases expression
multiple interactions		 EXP Caffeine results in increased expression of NPPB mRNA
Dantrolene inhibits the reaction [Caffeine results in increased expression of NPPB mRNA]		 CTD PMID:25093688 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of NQO1 mRNA CTD PMID:28843594 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression EXP Caffeine results in increased expression of NR3C1 mRNA; Caffeine results in increased expression of NR3C1 protein CTD PMID:22583948 PMID:30423288 PMID:30528684 PMID:30776459 PMID:31306741 PMID:32663519 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Caffeine results in increased expression of NR3C2 mRNA CTD PMID:22959462 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 increases methylation
decreases expression		 EXP Caffeine results in increased methylation of NR5A1 promoter
Caffeine results in decreased expression of NR5A1 mRNA; Caffeine results in decreased expression of NR5A1 protein		 CTD PMID:24717552 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Nrf1 nuclear respiratory factor 1 decreases expression EXP Caffeine results in decreased expression of NRF1 mRNA CTD PMID:20864626 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NSF mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NSF mRNA] CTD PMID:20230807 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082 		JBrowse link
G Nt5e 5' nucleotidase, ecto decreases activity
multiple interactions		 EXP Caffeine results in decreased activity of NT5E protein
caffeic acid inhibits the reaction [Caffeine results in decreased activity of NT5E protein]; Caffeine promotes the reaction [caffeic acid results in decreased activity of NT5E protein]		 CTD PMID:28465162 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of NUPR1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NUPR1 mRNA] CTD PMID:20230807 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524 		JBrowse link
G Oat ornithine aminotransferase increases expression ISO Caffeine results in increased expression of OAT mRNA CTD PMID:11793227 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Caffeine results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO Caffeine results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820 		JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 increases expression EXP Caffeine results in increased expression of OXSR1 mRNA CTD PMID:20864626 NCBI chr 8:127,920,349...128,009,951
Ensembl chr 8:127,920,349...128,009,951 		JBrowse link
G P3h3 prolyl 3-hydroxylase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of P3H3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of P3H3 mRNA] CTD PMID:20230807 NCBI chr 4:157,359,331...157,375,186
Ensembl chr 4:157,359,332...157,372,861 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 decreases expression EXP Caffeine results in decreased expression of PAK1 mRNA CTD PMID:29343424 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 multiple interactions
increases activity		 ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PAK2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PAK2 mRNA]
Caffeine results in increased activity of PAK2 protein		 CTD PMID:19325779 PMID:20230807 NCBI chr11:72,829,407...72,865,815
Ensembl chr11:72,829,238...72,865,902
Ensembl chr11:72,829,238...72,865,902 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects cleavage
decreases response to substance
multiple interactions
increases cleavage		 ISO
EXP		 Caffeine affects the cleavage of PARP1 protein
PARP1 protein results in decreased susceptibility to Caffeine
Caffeine inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]
[Caffeine co-treated with Alprazolam] results in increased activity of PARP1 protein; [PARP1 protein results in decreased susceptibility to Caffeine] promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased expression of CDKN1A mRNA]; Caffeine promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; Caffeine results in increased cleavage of and results in increased expression of PARP1 protein
Caffeine results in increased cleavage of PARP1 protein		 CTD PMID:16522534 PMID:19242509 PMID:19490937 PMID:21229324 PMID:21840268 PMID:22226932 PMID:30377735 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pax3 paired box 3 decreases expression ISO Caffeine results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172 		JBrowse link
G Pcare photoreceptor cilium actin regulator decreases expression ISO Caffeine results in decreased expression of PCARE protein CTD PMID:31195006 NCBI chr 6:23,337,507...23,346,232
Ensembl chr 6:23,337,571...23,346,173 		JBrowse link
G Pcna proliferating cell nuclear antigen affects expression EXP Caffeine affects the expression of PCNA mRNA; Caffeine affects the expression of PCNA protein CTD PMID:29343424 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression EXP Caffeine results in decreased expression of PCSK9 mRNA CTD PMID:25868845 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726 		JBrowse link
G Pde11a phosphodiesterase 11A decreases expression EXP Caffeine results in decreased expression of PDE11A mRNA CTD PMID:20864626 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845 		JBrowse link
G Pde5a phosphodiesterase 5A decreases expression EXP Caffeine results in decreased expression of PDE5A mRNA CTD PMID:20864626 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576 		JBrowse link
G Pdhx pyruvate dehydrogenase complex, component X decreases expression EXP Caffeine results in decreased expression of PDHX mRNA CTD PMID:20864626 NCBI chr 3:92,910,300...92,933,725
Ensembl chr 3:92,909,725...92,969,050 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PDIA6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDIA6 mRNA] CTD PMID:20230807 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652 		JBrowse link
G Pfdn1 prefoldin subunit 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PFDN1 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PFDN1 mRNA] CTD PMID:20230807 NCBI chr18:29,233,987...29,290,447
Ensembl chr18:29,233,987...29,290,447 		JBrowse link
G Pfkm phosphofructokinase, muscle affects expression ISO Caffeine affects the expression of PFKM protein CTD PMID:25486098 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132 		JBrowse link
G Pgk2 phosphoglycerate kinase 2 decreases expression ISO Caffeine results in decreased expression of PGK2 protein CTD PMID:31195006 NCBI chr 9:24,095,774...24,097,340
Ensembl chr 9:24,095,751...24,097,337 		JBrowse link
G Pgr progesterone receptor increases expression EXP Caffeine results in increased expression of PGR mRNA CTD PMID:20864626 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Phb prohibitin multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA] CTD PMID:20230807 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878 		JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Caffeine results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982 		JBrowse link
G Phtf1 putative homeodomain transcription factor 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PHTF1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHTF1 mRNA] CTD PMID:20230807 NCBI chr 2:206,452,115...206,518,387
Ensembl chr 2:206,454,208...206,493,030 		JBrowse link
G Pidd1 p53-induced death domain protein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIDD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIDD1 mRNA] CTD PMID:20230807 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
Ensembl chr 1:214,419,240...214,423,881 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA] CTD PMID:20230807 NCBI chr13:79,886,832...79,889,305
Ensembl chr13:79,886,832...79,889,304 		JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIP5K1C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIP5K1C mRNA] CTD PMID:20230807 NCBI chr 7:11,267,207...11,294,291
Ensembl chr 7:11,267,218...11,294,249 		JBrowse link
G Pitx2 paired-like homeodomain 2 decreases expression EXP Caffeine results in decreased expression of PITX2 mRNA CTD PMID:20864626 NCBI chr 2:233,602,732...233,621,059
Ensembl chr 2:233,602,732...233,621,129 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting multiple interactions
affects response to substance		 ISO PKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]
PKD1 protein affects the susceptibility to Caffeine		 CTD PMID:18679710 NCBI chr10:13,914,057...13,962,008
Ensembl chr10:13,915,214...13,962,008 		JBrowse link
G Pla2g12a phospholipase A2, group XIIA multiple interactions ISO [Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of PLA2G12A mRNA CTD PMID:28843594 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972 		JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions
decreases expression		 EXP Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased activity of PLCB1 protein]
Caffeine results in decreased expression of PLCB1 protein		 CTD PMID:15998294 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545 		JBrowse link
G Plec plectin decreases expression ISO Caffeine results in decreased expression of PLEC protein CTD PMID:31195006 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961 		JBrowse link
G Plg plasminogen decreases expression EXP Caffeine results in decreased expression of PLG mRNA CTD PMID:25868845 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776 		JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Caffeine results in increased expression of PLP1 mRNA CTD PMID:18444173 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348 		JBrowse link
G Pls1 plastin 1 increases expression ISO Caffeine results in increased expression of PLS1 protein CTD PMID:31195006 NCBI chr 8:103,557,361...103,659,625
Ensembl chr 8:103,557,364...103,608,913 		JBrowse link
G Pls3 plastin 3 decreases expression ISO Caffeine results in decreased expression of PLS3 protein CTD PMID:31195006 NCBI chr  X:119,030,311...119,124,268
Ensembl chr  X:119,030,419...119,124,250 		JBrowse link
G Pnp purine nucleoside phosphorylase increases expression EXP Caffeine results in increased expression of PNP protein CTD PMID:6149265 NCBI chr15:27,875,883...27,883,566
Ensembl chr15:27,875,911...27,883,350 		JBrowse link
G Pnpla8 patatin-like phospholipase domain containing 8 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PNPLA8 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PNPLA8 mRNA] CTD PMID:20230807 NCBI chr 6:64,224,870...64,288,465
Ensembl chr 6:64,224,861...64,286,785 		JBrowse link
G Pomc proopiomelanocortin increases secretion EXP Caffeine results in increased secretion of POMC protein alternative form CTD PMID:22959462 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression EXP Caffeine results in decreased expression of PPARA mRNA CTD PMID:30776459 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO
EXP		 Caffeine results in decreased expression of PPARG mRNA CTD PMID:23727198 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Caffeine results in increased expression of PPARGC1A mRNA CTD PMID:17516843 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression ISO Caffeine results in increased expression of PPFIBP1 protein CTD PMID:31195006 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157 		JBrowse link
G Ppial4g peptidylprolyl isomerase A like 4G decreases expression ISO Caffeine results in decreased expression of PPIAL4G protein CTD PMID:31195006 NCBI chr15:81,576,690...81,577,379
Ensembl chr15:81,576,888...81,577,379 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPM1B mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PPM1B mRNA] CTD PMID:20230807 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression ISO Caffeine results in decreased expression of PPP2R2B mRNA CTD PMID:18444173 NCBI chr18:36,985,709...37,421,383
Ensembl chr18:36,985,714...37,245,809 		JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PPP2R3C mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PPP2R3C mRNA] CTD PMID:20230807 NCBI chr 6:76,056,585...76,079,755
Ensembl chr 6:76,056,499...76,079,664 		JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO Caffeine results in increased expression of PRDX2 protein CTD PMID:31195006 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094 		JBrowse link
G Prelid1 PRELI domain containing 1 decreases expression ISO Caffeine results in decreased expression of PRELID1 mRNA CTD PMID:11793227 NCBI chr17:9,834,245...9,837,285
Ensembl chr17:9,834,242...9,837,303 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Caffeine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases expression EXP Caffeine results in increased expression of PRKAA2 mRNA CTD PMID:22583948 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases expression ISO
EXP		 Caffeine results in decreased expression of PRKACA protein CTD PMID:30825513 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha decreases expression EXP Caffeine results in decreased expression of PRKAR1A mRNA CTD PMID:29343424 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336 		JBrowse link
G Prkcsh protein kinase C substrate 80K-H increases expression ISO Caffeine results in increased expression of PRKCSH protein CTD PMID:31195006 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit multiple interactions ISO Caffeine promotes the reaction [Aphidicolin promotes the reaction [PRKDC protein results in increased phosphorylation of and results in increased activity of CHEK2 protein]]
PRKDC protein affects the susceptibility to [Caffeine co-treated with Benzo(a)pyrene]		 CTD PMID:18158334 PMID:20888899 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Prmt3 protein arginine methyltransferase 3 decreases expression EXP Caffeine results in decreased expression of PRMT3 mRNA CTD PMID:20864626 NCBI chr 1:105,113,595...105,200,253
Ensembl chr 1:105,113,595...105,200,470 		JBrowse link
G Prnp prion protein decreases expression ISO Caffeine results in decreased expression of PRNP mRNA CTD PMID:18444173 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316 		JBrowse link
G Prorsd1 prolyl-tRNA synthetase associated domain containing 1 decreases expression EXP Caffeine results in decreased expression of PRORSD1 mRNA CTD PMID:20864626 NCBI chr14:113,938,061...113,940,330
Ensembl chr14:113,938,061...113,940,330 		JBrowse link
G Prph peripherin decreases expression ISO Caffeine results in decreased expression of PRPH protein CTD PMID:31195006 NCBI chr 7:140,742,406...140,746,197
Ensembl chr 7:140,742,418...140,746,197 		JBrowse link
G Psma2 proteasome 20S subunit alpha 2 decreases expression ISO Caffeine results in decreased expression of PSMA2 protein CTD PMID:31195006 NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression ISO Caffeine results in increased expression of PSMA5 protein CTD PMID:31195006 NCBI chr 2:211,050,344...211,073,706
Ensembl chr 2:211,050,360...211,073,714 		JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 decreases expression ISO Caffeine results in decreased expression of PSMC3 protein CTD PMID:31195006 NCBI chr 3:79,876,938...79,882,319
Ensembl chr 3:79,876,938...79,882,319 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 increases expression ISO Caffeine results in increased expression of PSMC4 protein CTD PMID:31195006 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PSMC5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PSMC5 mRNA] CTD PMID:20230807 NCBI chr10:94,445,877...94,451,811
Ensembl chr10:94,445,877...94,451,811 		JBrowse link
G Psme3 proteasome activator subunit 3 decreases expression ISO Caffeine results in decreased expression of PSME3 mRNA CTD PMID:11793227 NCBI chr10:89,236,256...89,244,041
Ensembl chr10:89,236,256...89,244,041 		JBrowse link
G Ptgfrn prostaglandin F2 receptor inhibitor increases expression EXP Caffeine results in increased expression of PTGFRN mRNA CTD PMID:20864626 NCBI chr 2:203,423,143...203,494,391
Ensembl chr 2:203,423,143...203,494,391 		JBrowse link
G Ptgr1 prostaglandin reductase 1 decreases expression EXP Caffeine results in decreased expression of PTGR1 mRNA CTD PMID:25868845 NCBI chr 5:76,110,746...76,129,361
Ensembl chr 5:76,110,738...76,129,441 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 ISO Caffeine results in decreased expression of PTGS2 protein
Caffeine inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]		 CTD PMID:21561856 PMID:22974838 PMID:26852703 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Pwp2 PWP2, small subunit processome component decreases expression EXP Caffeine results in decreased expression of PWP2 mRNA CTD PMID:20864626 NCBI chr20:11,228,892...11,243,204
Ensembl chr20:11,228,844...11,243,205 		JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 increases expression EXP Caffeine results in increased expression of QARS1 mRNA CTD PMID:20864626 NCBI chr 8:117,297,670...117,305,708
Ensembl chr 8:117,297,670...117,305,702 		JBrowse link
G Qrsl1 glutaminyl-tRNA amidotransferase subunit QRSL1 decreases expression EXP Caffeine results in decreased expression of QRSL1 mRNA CTD PMID:20864626 NCBI chr20:48,855,839...48,881,112
Ensembl chr20:48,855,914...48,881,119 		JBrowse link
G Rab3ip RAB3A interacting protein increases expression EXP Caffeine results in increased expression of RAB3IP mRNA CTD PMID:20864626 NCBI chr 7:59,927,486...59,971,518
Ensembl chr 7:59,928,426...59,957,232 		JBrowse link
G Rab5c RAB5C, member RAS oncogene family decreases expression ISO Caffeine results in decreased expression of RAB5C protein CTD PMID:31195006 NCBI chr10:88,621,924...88,645,364
Ensembl chr10:88,621,925...88,645,364 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAB7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RAB7 mRNA] CTD PMID:20230807 NCBI chr 4:119,910,461...119,963,065
Ensembl chr 4:119,910,478...119,959,173 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 decreases expression EXP Caffeine results in decreased expression of RABGEF1 mRNA CTD PMID:20864626 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959 		JBrowse link
G Rabl3 RAB, member of RAS oncogene family-like 3 decreases expression EXP Caffeine results in decreased expression of RABL3 mRNA CTD PMID:20864626 NCBI chr11:66,049,635...66,078,669
Ensembl chr11:66,049,635...66,078,669 		JBrowse link
G Rac2 Rac family small GTPase 2 increases expression ISO Caffeine results in increased expression of RAC2 protein CTD PMID:31195006 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098 		JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD1 mRNA] CTD PMID:20230807 NCBI chr 2:60,461,513...60,469,646
Ensembl chr 2:60,461,551...60,469,685 		JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RAD50 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RAD50 mRNA] CTD PMID:20230807 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142 		JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Caffeine results in increased expression of RAD51AP1 protein CTD PMID:20025956 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869 		JBrowse link
G Ralgapb Ral GTPase activating protein non-catalytic subunit beta decreases expression ISO Caffeine results in decreased expression of RALGAPB protein CTD PMID:31195006 NCBI chr 3:154,910,291...154,983,021
Ensembl chr 3:154,905,141...154,983,021 		JBrowse link
G Ran RAN, member RAS oncogene family increases expression ISO Caffeine results in increased expression of RAN protein CTD PMID:31195006 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810 		JBrowse link
G Rasa3 RAS p21 protein activator 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RASA3 mRNA; Caffeine promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RASA3 mRNA] CTD PMID:20230807 NCBI chr16:81,320,090...81,434,239
Ensembl chr16:81,318,633...81,434,363 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Caffeine results in decreased phosphorylation of RB1 protein CTD PMID:15126379 PMID:21229324 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342 		JBrowse link
G Rbbp4 RB binding protein 4, chromatin remodeling factor multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP4 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RBBP4 mRNA] CTD PMID:20230807 NCBI chr 5:147,499,880...147,535,240
Ensembl chr 5:147,499,882...147,535,240 		JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RBBP5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RBBP5 mRNA] CTD PMID:20230807 NCBI chr13:49,250,301...49,277,152
Ensembl chr13:49,250,301...49,277,152 		JBrowse link
G Rbm12 RNA binding motif protein 12 decreases expression EXP Caffeine results in decreased expression of RBM12 mRNA CTD PMID:20864626 NCBI chr 3:151,616,038...151,658,427
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417
Ensembl chr 3:151,641,095...151,658,417 		JBrowse link
G Rbmx RNA binding motif protein, X-linked decreases expression ISO Caffeine results in decreased expression of RBMX protein CTD PMID:31195006 NCBI chr  X:159,881,835...159,891,405
Ensembl chr  X:159,884,885...159,891,326 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Caffeine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein]; Caffeine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:22974838 PMID:26852703 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ren renin increases expression
increases secretion
increases activity		 EXP
ISO		 Caffeine results in increased expression of REN protein
Caffeine results in increased secretion of REN protein
Caffeine results in increased activity of REN protein		 CTD PMID:1860718 PMID:3020089 PMID:3044993 PMID:8244516 PMID:10803761 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RGS2 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA] CTD PMID:20230807 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094 		JBrowse link
G Rhebl1 RHEB like 1 increases expression EXP Caffeine results in increased expression of RHEBL1 mRNA CTD PMID:20864626 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639 		JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 decreases expression EXP Caffeine results in decreased expression of RIMS2 mRNA CTD PMID:20864626 NCBI chr 7:78,091,998...78,594,164
Ensembl chr 7:78,092,037...78,594,138 		JBrowse link
G Rnf166 ring finger protein 166 increases expression EXP Caffeine results in increased expression of RNF166 mRNA CTD PMID:20864626 NCBI chr19:55,290,563...55,300,403
Ensembl chr19:55,290,563...55,300,403 		JBrowse link
G Rnh1 ribonuclease/angiogenin inhibitor 1 decreases expression ISO Caffeine results in decreased expression of RNH1 protein CTD PMID:31195006 NCBI chr 1:214,151,341...214,163,807
Ensembl chr 1:214,151,338...214,163,808 		JBrowse link
G Rpia ribose 5-phosphate isomerase A decreases expression EXP Caffeine results in decreased expression of RPIA mRNA CTD PMID:20864626 NCBI chr 4:98,568,028...98,593,664
Ensembl chr 4:98,568,028...98,593,664 		JBrowse link
G Rpl10a ribosomal protein L10A decreases expression ISO Caffeine results in decreased expression of RPL10A protein CTD PMID:31195006 NCBI chr20:7,908,309...7,910,867
Ensembl chr20:7,908,304...7,910,867 		JBrowse link
G Rpl13 ribosomal protein L13 decreases expression ISO Caffeine results in decreased expression of RPL13 protein CTD PMID:31195006 NCBI chr19:55,917,489...55,920,040
Ensembl chr19:55,917,736...55,919,996 		JBrowse link
G Rpl17 ribosomal protein L17 increases expression ISO Caffeine results in increased expression of RPL17 protein CTD PMID:31195006 NCBI chr18:70,969,733...70,972,839
Ensembl chr18:70,970,596...70,975,494 		JBrowse link
G Rpl26 ribosomal protein L26 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RPL26 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RPL26 mRNA] CTD PMID:20230807 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012 		JBrowse link
G Rpl27a ribosomal protein L27a increases expression ISO Caffeine results in increased expression of RPL27A protein CTD PMID:31195006 NCBI chr 1:174,132,798...174,135,816
Ensembl chr 1:174,132,798...174,135,816 		JBrowse link
G Rpl29 ribosomal protein L29 increases expression ISO Caffeine results in increased expression of RPL29 protein CTD PMID:31195006 NCBI chr 8:115,131,228...115,133,401
Ensembl chr 8:115,131,367...115,133,401 		JBrowse link
G Rpl36 ribosomal protein L36 increases expression ISO Caffeine results in increased expression of RPL36 protein CTD PMID:31195006 NCBI chr 9:10,441,228...10,441,981
Ensembl chr 9:10,441,259...10,441,834 		JBrowse link
G Rpl36a ribosomal protein L36a decreases expression ISO Caffeine results in decreased expression of RPL36A protein CTD PMID:31195006 NCBI chr  X:105,402,867...105,405,580
Ensembl chr  X:105,402,867...105,405,580 		JBrowse link
G Rpl4 ribosomal protein L4 increases expression ISO Caffeine results in increased expression of RPL4 protein CTD PMID:31195006 NCBI chr 8:69,121,682...69,126,805
Ensembl chr 8:69,121,682...69,126,805 		JBrowse link
G Rpl5 ribosomal protein L5 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RPL5 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RPL5 mRNA] CTD PMID:20230807 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397 		JBrowse link
G Rpl7a ribosomal protein L7a increases expression ISO Caffeine results in increased expression of RPL7A protein CTD PMID:31195006 NCBI chr 3:5,458,985...5,461,627
Ensembl chr 3:5,459,160...5,461,583
Ensembl chr 3:5,459,160...5,461,583 		JBrowse link
G Rpn1 ribophorin I increases expression ISO Caffeine results in increased expression of RPN1 protein CTD PMID:31195006 NCBI chr 4:119,997,232...120,018,687
Ensembl chr 4:119,997,268...120,018,679 		JBrowse link
G Rpn2 ribophorin II increases expression ISO Caffeine results in increased expression of RPN2 protein CTD PMID:31195006 NCBI chr 3:153,398,373...153,445,633
Ensembl chr 3:153,398,130...153,445,632 		JBrowse link
G Rps11 ribosomal protein S11 increases expression ISO Caffeine results in increased expression of RPS11 protein CTD PMID:31195006 NCBI chr 1:101,116,641...101,118,749
Ensembl chr 1:101,116,635...101,118,825 		JBrowse link
G Rps14 ribosomal protein S14 increases expression ISO Caffeine results in increased expression of RPS14 protein CTD PMID:31195006 NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316 		JBrowse link
G Rps18 ribosomal protein S18 increases expression ISO Caffeine results in increased expression of RPS18 protein CTD PMID:31195006 NCBI chr20:5,441,875...5,445,553
Ensembl chr20:5,441,876...5,445,553 		JBrowse link
G Rps19 ribosomal protein S19 decreases expression ISO Caffeine results in decreased expression of RPS19 protein CTD PMID:31195006 NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627 		JBrowse link
G Rps20 ribosomal protein S20 decreases expression ISO Caffeine results in decreased expression of RPS20 protein CTD PMID:31195006 NCBI chr 5:16,706,052...16,707,214
Ensembl chr 5:16,706,082...16,706,909 		JBrowse link
G Rps28 ribosomal protein S28 decreases expression ISO Caffeine results in decreased expression of RPS28 protein CTD PMID:31195006 NCBI chr 7:18,682,071...18,683,440
Ensembl chr 7:18,682,071...18,683,440 		JBrowse link
G Rps3a ribosomal protein S3a increases expression ISO Caffeine results in increased expression of RPS3A protein CTD PMID:31195006 NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897 		JBrowse link
G Rps6 ribosomal protein S6 decreases expression ISO
EXP		 Caffeine results in decreased expression of RPS6 protein modified form CTD PMID:21081844 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression ISO Caffeine results in decreased expression of RPS6KA3 mRNA CTD PMID:11793227 NCBI chr  X:37,469,736...37,576,055
Ensembl chr  X:37,469,937...37,575,624 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO
EXP		 Caffeine results in decreased expression of RPS6KB1 protein modified form CTD PMID:21081844 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 mRNA]; Caffeine inhibits the reaction [Camptothecin results in increased expression of RRM2 protein] CTD PMID:22403396 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515 		JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO Caffeine results in increased expression of RRS1 mRNA CTD PMID:11793227 NCBI chr 5:9,430,710...9,432,343
Ensembl chr 5:9,430,728...9,432,343 		JBrowse link
G Rspo3 R-spondin 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RSPO3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of RSPO3 mRNA] CTD PMID:20230807 NCBI chr 1:30,681,648...30,768,038
Ensembl chr 1:30,681,681...30,766,860 		JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression EXP Caffeine results in decreased expression of RUNX2 mRNA CTD PMID:30423288 PMID:31874197 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092 		JBrowse link
G Rwdd2b RWD domain containing 2B decreases expression EXP Caffeine results in decreased expression of RWDD2B mRNA CTD PMID:20864626 NCBI chr11:27,085,708...27,094,364
Ensembl chr11:27,085,711...27,094,364 		JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
increases response to substance
multiple interactions		 ISO Caffeine results in increased activity of RYR1 protein
RYR1 gene mutant form results in increased susceptibility to Caffeine; RYR1 protein mutant form results in increased susceptibility to Caffeine
[Caffeine results in increased activity of RYR1 protein] which affects the localization of Calcium; RYR1 protein polymorphism affects the reaction [Caffeine results in increased secretion of Calcium]
TRPC3 protein affects the reaction [Caffeine results in increased activity of RYR1 protein]		 CTD PMID:14641996 PMID:15210166 PMID:16372898 PMID:16484216 PMID:18719443 PMID:19191329 PMID:21485675 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Dantrolene inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]]; HOMER1 protein alternative form inhibits the reaction [Caffeine promotes the reaction [RYR2 protein results in increased secretion of Calcium]] CTD PMID:12887973 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606 		JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Caffeine results in increased expression of S100A10 protein CTD PMID:31195006 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236 		JBrowse link
G S100a6 S100 calcium binding protein A6 decreases expression ISO Caffeine results in decreased expression of S100A6 protein CTD PMID:31195006 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511 		JBrowse link
G Sap18 Sin3A associated protein 18 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SAP18 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SAP18 mRNA] CTD PMID:20230807 NCBI chr15:38,069,320...38,073,625
Ensembl chr15:38,069,320...38,073,622 		JBrowse link
G Sc5d sterol-C5-desaturase decreases expression EXP Caffeine results in decreased expression of SC5D mRNA CTD PMID:25868845 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
increases methylation		 EXP Caffeine results in decreased expression of SCARB1 mRNA; Caffeine results in decreased expression of SCARB1 protein
Caffeine inhibits the reaction [Dietary Fats results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 mRNA]; Caffeine inhibits the reaction [Lipopolysaccharides results in increased expression of SCARB1 protein]
Caffeine results in increased methylation of SCARB1 promoter		 CTD PMID:25868845 PMID:29800656 PMID:29958987 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
multiple interactions		 EXP
ISO		 Caffeine results in decreased expression of SCD1 mRNA
[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in decreased expression of SCD1 mRNA		 CTD PMID:20864626 PMID:28843594 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Scfd1 sec1 family domain containing 1 decreases expression ISO Caffeine results in decreased expression of SCFD1 mRNA CTD PMID:11793227 NCBI chr 6:72,124,408...72,202,703
Ensembl chr 6:72,124,417...72,202,713 		JBrowse link
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component decreases expression ISO Caffeine results in decreased expression of SEC13 mRNA CTD PMID:11793227 NCBI chr 4:145,686,186...145,699,577
Ensembl chr 4:145,686,193...145,699,577 		JBrowse link
G Sec23a Sec23 homolog A, COPII coat complex component decreases expression ISO Caffeine results in decreased expression of SEC23A mRNA CTD PMID:11793227 NCBI chr 6:80,059,742...80,107,340
Ensembl chr 6:80,060,916...80,107,236 		JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SENP6 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SENP6 mRNA] CTD PMID:20230807 NCBI chr 8:87,486,050...87,568,088
Ensembl chr 8:87,486,427...87,563,652 		JBrowse link
G Septin7 septin 7 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SEPTIN7 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SEPTIN7 mRNA] CTD PMID:20230807 NCBI chr 8:26,412,910...26,476,615
Ensembl chr 8:26,413,233...26,476,611 		JBrowse link
G Serbp1 Serpine1 mRNA binding protein 1 decreases expression ISO Caffeine results in decreased expression of SERBP1 protein CTD PMID:31195006 NCBI chr 4:98,027,563...98,044,717
Ensembl chr 4:98,027,554...98,044,566 		JBrowse link
G Serpina1 serpin family A member 1 increases expression ISO Caffeine results in increased expression of SERPINA1 mRNA CTD PMID:18444173 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265 		JBrowse link
G Serpina6 serpin family A member 6 decreases expression ISO Caffeine results in decreased expression of SERPINA6 mRNA CTD PMID:11793227 NCBI chr 6:127,523,948...127,534,178
Ensembl chr 6:127,523,906...127,534,247 		JBrowse link
G Sfpq splicing factor proline and glutamine rich multiple interactions
increases expression		 ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SFPQ mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SFPQ mRNA]
Caffeine results in increased expression of SFPQ protein		 CTD PMID:20230807 PMID:31195006 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498 		JBrowse link
G Sfrp1 secreted frizzled-related protein 1 multiple interactions EXP Caffeine inhibits the reaction [Doxorubicin results in increased secretion of SFRP1 protein] CTD PMID:30377735 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 increases expression EXP Caffeine results in increased expression of APS mRNA CTD PMID:20864626 NCBI chr12:23,471,477...23,501,043
Ensembl chr12:23,473,270...23,501,036 		JBrowse link
G Sharpin SHANK-associated RH domain interactor increases expression EXP Caffeine results in increased expression of SHARPIN mRNA CTD PMID:20864626 NCBI chr 7:117,413,151...117,417,455
Ensembl chr 7:117,413,152...117,417,363 		JBrowse link
G Sigmar1 sigma non-opioid intracellular receptor 1 decreases expression EXP Caffeine results in decreased expression of SIGMAR1 mRNA CTD PMID:20864626 NCBI chr 5:58,121,824...58,124,687
Ensembl chr 5:58,121,786...58,124,681 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 EXP
ISO		 Caffeine results in decreased expression of SIRT1 mRNA; Caffeine results in decreased expression of SIRT1 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Colforsin inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Caffeine results in decreased expression of SIRT1 mRNA]		 CTD PMID:30776459 PMID:30825513 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]]; Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 protein]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; SIRT3 protein promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; SIRT3 protein promotes the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; SIRT3 protein promotes the reaction [Caffeine results in increased expression of BECN1 protein] CTD PMID:30555576 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions
increases expression		 ISO Caffeine affects the reaction [SLC16A1 protein results in increased uptake of Butyrates]
Caffeine results in increased expression of SLC16A1 mRNA		 CTD PMID:19023563 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554 		JBrowse link
G Slc17a5 solute carrier family 17 member 5 increases expression EXP Caffeine results in increased expression of SLC17A5 mRNA CTD PMID:20864626 NCBI chr 8:85,891,245...85,926,466
Ensembl chr 8:85,891,257...85,926,450 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 decreases activity
multiple interactions		 EXP Caffeine results in decreased activity of SLC1A1 protein
Caffeine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of SLC1A1 protein]		 CTD PMID:23262392 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056 		JBrowse link
G Slc25a37 solute carrier family 25 member 37 decreases expression EXP Caffeine results in decreased expression of SLC25A37 mRNA CTD PMID:20864626 NCBI chr15:51,125,764...51,168,384
Ensembl chr15:51,128,268...51,168,384 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Caffeine results in increased expression of SLC2A1 protein CTD PMID:25486098 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Slc2a10 solute carrier family 2 member 10 decreases expression ISO Caffeine results in decreased expression of SLC2A10 protein CTD PMID:31195006 NCBI chr 3:162,182,156...162,194,610
Ensembl chr 3:162,181,974...162,194,804 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Caffeine results in increased expression of SLC2A3 protein CTD PMID:25486098 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Slc30a7 solute carrier family 30 member 7 decreases expression EXP Caffeine results in decreased expression of SLC30A7 mRNA CTD PMID:20864626 NCBI chr 2:218,888,431...218,951,030
Ensembl chr 2:218,888,431...218,951,030 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Caffeine affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Caffeine affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799 		JBrowse link
G Slc6a15 solute carrier family 6 member 15 multiple interactions ISO [Caffeine co-treated with Mianserin] results in decreased expression of SLC6A15 mRNA; [Caffeine co-treated with S 20098] results in decreased expression of SLC6A15 mRNA; [Citalopram co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA; [Fluoxetine co-treated with Caffeine] results in decreased expression of SLC6A15 mRNA CTD PMID:29107002 PMID:29882086 NCBI chr 7:45,328,207...45,381,920
Ensembl chr 7:45,328,105...45,382,229 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases response to substance
affects response to substance		 ISO SLC6A3 gene mutant form results in increased susceptibility to Caffeine
SLC6A3 gene polymorphism affects the susceptibility to Caffeine		 CTD PMID:11222668 PMID:24403155 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Slc8b1 solute carrier family 8 member B1 increases expression EXP Caffeine results in increased expression of SLC8B1 mRNA CTD PMID:20864626 NCBI chr12:41,566,980...41,590,294
Ensembl chr12:41,566,981...41,590,244 		JBrowse link
G Smad1 SMAD family member 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMAD1 mRNA] CTD PMID:20230807 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684 		JBrowse link
G Smad2 SMAD family member 2 decreases expression EXP Caffeine results in decreased expression of SMAD2 mRNA; Caffeine results in decreased expression of SMAD2 protein CTD PMID:32663519 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression		 ISO
EXP		 [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMAD3 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SMAD3 mRNA]
Caffeine results in decreased expression of SMAD3 mRNA		 CTD PMID:20230807 PMID:32663519 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Smox spermine oxidase increases expression ISO Caffeine results in increased expression of SMOX mRNA CTD PMID:11793227 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of SMPD3 mRNA; Caffeine affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SMPD3 mRNA] CTD PMID:20230807 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528 		JBrowse link
G Snx3 sorting nexin 3 increases expression EXP Caffeine results in increased expression of SNX3 mRNA CTD PMID:20864626 NCBI chr20:47,225,382...47,263,390
Ensembl chr20:47,225,619...47,263,390 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [Caffeine co-treated with bisphenol A] results in decreased expression of SOD1 mRNA CTD PMID:31756439 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 EXP
ISO		 Caffeine results in increased expression of SOD2 protein
[Caffeine co-treated with bisphenol A] results in decreased expression of SOD2 mRNA		 CTD PMID:23099337 PMID:31756439 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Caffeine results in decreased expression of SORL1 mRNA CTD PMID:25868845 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Caffeine results in increased expression of SOWAHA protein CTD PMID:31195006 NCBI chr10:38,836,158...38,838,932
Ensembl chr10:38,836,614...38,838,272 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Caffeine results in decreased expression of SOX9 mRNA; Caffeine results in decreased expression of SOX9 protein CTD PMID:31874197 PMID:32663519 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression EXP Caffeine results in decreased expression of SPP1 mRNA CTD PMID:30423288 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901 		JBrowse link
G Sqle squalene epoxidase decreases expression
increases expression		 EXP
ISO		 Caffeine results in decreased expression of SQLE mRNA
Caffeine results in increased expression of SQLE mRNA		 CTD PMID:11793227 PMID:20864626 PMID:25868845 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Caffeine results in increased expression of SQSTM1 mRNA
Caffeine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]
Caffeine results in decreased expression of SQSTM1 protein		 CTD PMID:20864626 PMID:21081844 PMID:22927544 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP Caffeine results in increased expression of SREBF1 mRNA; Caffeine results in increased expression of SREBF1 protein CTD PMID:30776459 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 increases expression
multiple interactions		 EXP
ISO		 Caffeine results in increased expression of SREBF2 mRNA; Caffeine results in increased expression of SREBF2 protein
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Colforsin inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]; Resveratrol inhibits the reaction [Caffeine results in increased expression of SREBF2 mRNA]		 CTD PMID:30825513 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Srp9 signal recognition particle 9 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SRP9 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SRP9 mRNA] CTD PMID:20230807 NCBI chr13:100,551,307...100,559,447
Ensembl chr13:100,551,307...100,559,447 		JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 decreases expression ISO Caffeine results in decreased expression of SRSF1 mRNA CTD PMID:11793227 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197 		JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 increases expression ISO Caffeine results in increased expression of SRSF2 protein CTD PMID:31195006 NCBI chr10:105,792,779...105,795,986
Ensembl chr10:105,792,779...105,795,958 		JBrowse link
G Ssc4d scavenger receptor cysteine rich family member with 4 domains increases expression ISO Caffeine results in increased expression of SSC4D protein CTD PMID:31195006 NCBI chr12:23,752,823...23,769,466
Ensembl chr12:23,752,844...23,762,877 		JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO Caffeine results in increased expression of ST13 protein CTD PMID:31195006 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731 		JBrowse link
G Star steroidogenic acute regulatory protein decreases methylation
increases expression
decreases expression		 ISO
EXP		 Caffeine results in decreased methylation of STAR promoter
Caffeine results in increased expression of STAR mRNA
Caffeine results in decreased expression of STAR mRNA
Caffeine results in increased expression of STAR mRNA; Caffeine results in increased expression of STAR protein		 CTD PMID:22100783 PMID:24717552 PMID:25868845 PMID:30528684 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 decreases expression EXP Caffeine results in decreased expression of STARD4 mRNA CTD PMID:20864626 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555 		JBrowse link
G Stim1 stromal interaction molecule 1 increases expression EXP Caffeine results in increased expression of STIM1 mRNA CTD PMID:20864626 NCBI chr 1:167,373,894...167,533,412
Ensembl chr 1:167,373,678...167,533,420 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 multiple interactions ISO [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of STIP1 mRNA; Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of STIP1 mRNA] CTD PMID:20230807 NCBI chr 1:222,274,133...222,293,139
Ensembl chr 1:222,274,133...222,293,148 		JBrowse link
G Stmn1 stathmin 1 increases expression ISO Caffeine results in increased expression of STMN1 protein CTD PMID:20025956 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein decreases expression ISO Caffeine results in decreased expression of STRBP mRNA CTD PMID:11793227