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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
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Accession:CHEBI:50925 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
Synonyms:related_synonym: A-kinase inhibitor;   A-kinase inhibitors;   AP50 kinase inhibitor;   AP50 kinase inhibitors;   ATP-protein transphosphorylase inhibitor;   ATP-protein transphosphorylase inhibitors;   ATP:protein phosphotransferase (non-specific) inhibitor;   ATP:protein phosphotransferase (non-specific) inhibitors;   BR serine/threonine-protein kinase 2 inhibitor;   BR serine/threonine-protein kinase 2 inhibitors;   CK-2 inhibitor;   CK-2 inhibitors;   CKI inhibitor;   CKI inhibitors;   CKII inhibitor;   CKII inhibitors;   EC 2.7.11.1 inhibitor;   EC 2.7.11.1 inhibitors;   HIPK2 inhibitor;   HIPK2 inhibitors;   Hpr kinase inhibitor;   Hpr kinase inhibitors;   M phase-specific cdc2 kinase inhibitor;   M phase-specific cdc2 kinase inhibitors;   MKNK2 inhibitor;   MKNK2 inhibitors;   PAK-1 inhibitor;   PAK-1 inhibitors;   PAK1 inhibitor;   PAK1 inhibitors;   PKA inhibitor;   PKA inhibitors;   Prp4 protein kinase inhibitor;   Prp4 protein kinase inhibitors;   Raf kinase inhibitor;   Raf kinase inhibitors;   Raf-1 inhibitor;   Raf-1 inhibitors;   STK32 inhibitor;   STK32 inhibitors;   T-antigen kinase inhibitor;   T-antigen kinase inhibitors;   WEE1Hu inhibitor;   WEE1Hu inhibitors;   Wee 1-like kinase inhibitor;   Wee 1-like kinase inhibitors;   Wee-kinase inhibitor;   Wee-kinase inhibitors;   betaIIPKC inhibitor;   betaIIPKC inhibitors;   cAMP-dependent protein kinase A inhibitor;   cAMP-dependent protein kinase A inhibitors;   cAMP-dependent protein kinase inhibitor;   cAMP-dependent protein kinase inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   calcium-dependent protein kinase C inhibitor;   calcium-dependent protein kinase C inhibitors;   calcium/phospholipid-dependent protein kinase inhibitor;   calcium/phospholipid-dependent protein kinase inhibitors;   casein kinase (phosphorylating) inhibitor;   casein kinase (phosphorylating) inhibitors;   casein kinase 2 inhibitor;   casein kinase 2 inhibitors;   casein kinase I inhibitor;   casein kinase I inhibitors;   casein kinase II inhibitor;   casein kinase II inhibitors;   casein kinase inhibitor;   casein kinase inhibitors;   cyclic AMP-dependent protein kinase A inhibitor;   cyclic AMP-dependent protein kinase A inhibitors;   cyclic AMP-dependent protein kinase inhibitor;   cyclic AMP-dependent protein kinase inhibitors;   cyclic monophosphate-dependent protein kinase inhibitor;   cyclic monophosphate-dependent protein kinase inhibitors;   cyclic nucleotide-dependent protein kinase inhibitor;   cyclic nucleotide-dependent protein kinase inhibitors;   cyclin-dependent kinase inhibitor;   cyclin-dependent kinase inhibitors;   dsk1 inhibitor;   dsk1 inhibitors;   epsilon PKC inhibitor;   epsilon PKC inhibitors;   glycogen synthase a kinase inhibitor;   glycogen synthase a kinase inhibitors;   glycogen synthase kinase inhibitor;   glycogen synthase kinase inhibitors;   hydroxyalkyl-protein kinase inhibitor;   hydroxyalkyl-protein kinase inhibitors;   mitogen-activated S6 kinase inhibitor;   mitogen-activated S6 kinase inhibitors;   non-specific serine/threonine protein kinase (EC 2.7.11.1) inhibitors;   non-specific serine/threonine protein kinase inhibitor;   non-specific serine/threonine protein kinase inhibitors;   p21 activated kinase-1 inhibitor;   p21 activated kinase-1 inhibitors;   p82 kinase inhibitor;   p82 kinase inhibitors;   phosphorylase b kinase kinase inhibitor;   phosphorylase b kinase kinase inhibitors;   protein glutamyl kinase inhibitor;   protein glutamyl kinase inhibitors;   protein kinase (phosphorylating) inhibitor;   protein kinase (phosphorylating) inhibitors;   protein kinase A inhibitor;   protein kinase A inhibitors;   protein kinase CK2 inhibitor;   protein kinase CK2 inhibitors;   protein kinase p58 inhibitor;   protein kinase p58 inhibitors;   protein phosphokinase inhibitor;   protein phosphokinase inhibitors;   protein serine kinase inhibitor;   protein serine kinase inhibitors;   protein-aspartyl kinase inhibitor;   protein-aspartyl kinase inhibitors;   protein-cysteine kinase inhibitor;   protein-cysteine kinase inhibitors;   ribosomal S6 protein kinase inhibitor;   ribosomal S6 protein kinase inhibitors;   ribosomal protein S6 kinase II inhibitor;   ribosomal protein S6 kinase II inhibitors;   serine kinase inhibitor;   serine kinase inhibitors;   serine-specific protein kinase inhibitor;   serine-specific protein kinase inhibitors;   serine/threonine protein kinase inhibitor;   serine/threonine protein kinase inhibitors;   threonine-specific protein kinase inhibitor;   threonine-specific protein kinase inhibitors;   twitchin kinase inhibitor;   twitchin kinase inhibitors;   type-2 casein kinase inhibitor;   type-2 casein kinase inhibitors
 alt_id: CHEBI:75764



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    Path 1
    Term Annotations click to browse term
      CHEBI ontology 19831
        role 19807
          biological role 19805
            inhibitor 18895
              enzyme inhibitor 18723
                EC 2.* (transferase) inhibitor 14869
                  EC 2.7.* (P-containing group transferase) inhibitor 14366
                    EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10120
                      EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor 4572
                        (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane 0
                        (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride 0
                        (\{6-[4-(methylsulfanyl)phenyl]thieno[3,2-d]pyrimidin-4-yl\}sulfanyl)acetic acid 0
                        2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                        3-BrB-PP1 0
                        6-bromoindirubin-3'-oxime 36
                        AKI00000020a 0
                        AKT1 kinase inhibitor + 0
                        AT7867 0
                        B-Raf inhibitor + 94
                        CIGB-300 0
                        CZC-25146 0
                        GSK690693 17
                        GW296115X 0
                        HG-10-102-01 0
                        IPA-3 0
                        KU-55933 0
                        KU-60019 0
                        LRRK2-IN-1 0
                        MLI-2 0
                        N-(2-[(2-aminoethyl)(methyl)amino]-5-\{[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino\}phenyl)acetamide 0
                        N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
                        N-(2-methoxyethyl)-4-\{[6-(pyridin-4-yl)quinazolin-2-yl]amino\}benzamide 0
                        N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                        N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine 0
                        OSU-03012 2
                        PF-00477736 2
                        PF-4800567 0
                        PF-670462 1
                        PF-670462 free base 0
                        SB 203580 433
                        SGC-CK2-1 0
                        XL413 0
                        Y-27632 128
                        \{[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanyl\}acetic acid 0
                        alsterpaullone 7
                        caffeine + 3732
                        camonsertib 0
                        capivasertib 8
                        deguelin 794
                        fasudil 57
                        fasudil hydrochloride + 0
                        fasudil hydrochloride hydrate 0
                        hydrazinocurcumin 0
                        indirubin-3'-monoxime 49
                        quinalizarin 0
                        sorafenib + 179
    Path 2
    Term Annotations click to browse term
      CHEBI ontology 19831
        role 19807
          biological role 19805
            inhibitor 18895
              enzyme inhibitor 18723
                EC 2.* (transferase) inhibitor 14869
                  EC 2.7.* (P-containing group transferase) inhibitor 14366
                    protein kinase inhibitor 13982
                      EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10120
                        EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor 4572
                          (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane 0
                          (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane dihydrochloride 0
                          (\{6-[4-(methylsulfanyl)phenyl]thieno[3,2-d]pyrimidin-4-yl\}sulfanyl)acetic acid 0
                          2-(6-methoxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(piperazin-1-yl)pyridin-3-yl]-1,3-thiazole-4-carboxamide 0
                          3-BrB-PP1 0
                          6-bromoindirubin-3'-oxime 36
                          AKI00000020a 0
                          AKT1 kinase inhibitor + 0
                          AT7867 0
                          B-Raf inhibitor + 94
                          CIGB-300 0
                          CZC-25146 0
                          GSK690693 17
                          GW296115X 0
                          HG-10-102-01 0
                          IPA-3 0
                          KU-55933 0
                          KU-60019 0
                          LRRK2-IN-1 0
                          MLI-2 0
                          N-(2-[(2-aminoethyl)(methyl)amino]-5-\{[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino\}phenyl)acetamide 0
                          N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide 7
                          N-(2-methoxyethyl)-4-\{[6-(pyridin-4-yl)quinazolin-2-yl]amino\}benzamide 0
                          N-[5-(1-benzyl-1H-1,2,3-triazol-4-yl)-1H-indazol-3-yl]-N(2),N(2)-dimethylglycinamide 0
                          N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine 0
                          OSU-03012 2
                          PF-00477736 2
                          PF-4800567 0
                          PF-670462 1
                          PF-670462 free base 0
                          SB 203580 433
                          SGC-CK2-1 0
                          XL413 0
                          Y-27632 128
                          \{[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanyl\}acetic acid 0
                          alsterpaullone 7
                          caffeine + 3732
                          camonsertib 0
                          capivasertib 8
                          deguelin 794
                          fasudil 57
                          fasudil hydrochloride + 0
                          fasudil hydrochloride hydrate 0
                          hydrazinocurcumin 0
                          indirubin-3'-monoxime 49
                          quinalizarin 0
                          sorafenib + 179
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