lipid kinase inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lipid kinase inhibitor	go back to main search page
Accession:	CHEBI:50916	browse the term
Definition:	An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of lipid kinases.
Synonyms:	related_synonym:	lipid kinase inhibitors

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Rat (1033 ) Mouse (1074 ) Human (1061 ) Chinchilla (0 ) Bonobo (0 ) Dog (2 ) Squirrel (0 ) Pig (13 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (1033)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

erb-b2 receptor tyrosine kinase 3

increases phosphorylation
multiple interactions

ISO

N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime results in increased phosphorylation of ERBB3 protein
[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime results in increased phosphorylation of ERBB3 protein] which results in decreased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ISO

N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime inhibits the reaction [sodium arsenite results in increased expression of HSPA1A mRNA]

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

interleukin 1 beta

increases secretion
multiple interactions

EXP

N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime results in increased secretion of IL1B protein
[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime co-treated with N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime] results in increased secretion of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
increases secretion

EXP

[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime co-treated with tetrabromobisphenol A] results in increased secretion of IL6 protein
N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime results in increased secretion of IL6 protein

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of MAP2K1 protein

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 2

multiple interactions

ISO

[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in decreased phosphorylation of MAP2K2 protein

NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243

G

tumor necrosis factor

multiple interactions

EXP

[N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime co-treated with tetrabromobisphenol A] results in increased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

1,10-phenanthroline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

decreases expression

ISO

1,10-phenanthroline results in decreased expression of ACE mRNA

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131

G

aryl hydrocarbon receptor

decreases activity
multiple interactions

EXP
ISO

1,10-phenanthroline results in decreased activity of AHR protein
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; 1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]; Zinc inhibits the reaction [1,10-phenanthroline results in decreased activity of AHR protein]

PMID:1322109 PMID:2160969 PMID:27180721

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

adenylate kinase 1

decreases expression

ISO

1,10-phenanthroline results in decreased expression of AK1 mRNA

NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041

G

A-kinase anchoring protein 9

increases expression

ISO

1,10-phenanthroline results in increased expression of AKAP9 mRNA

NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606

G

aldo-keto reductase family 1, member C1

decreases activity

ISO

1,10-phenanthroline results in decreased activity of AKR1C1 protein

PMID:8573067 PMID:12604236

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

decreases activity

ISO

1,10-phenanthroline results in decreased activity of AKR1C2 protein

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

decreases activity

ISO

1,10-phenanthroline results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

aldolase, fructose-bisphosphate A

increases expression

ISO

1,10-phenanthroline results in increased expression of ALDOA mRNA

NCBI chr 1:190,832,820...190,838,021
Ensembl chr 1:181,402,275...181,406,182

G

aldolase, fructose-bisphosphate C

increases expression

ISO

1,10-phenanthroline results in increased expression of ALDOC mRNA

NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066

G

ankyrin repeat domain 37

increases expression

ISO

1,10-phenanthroline results in increased expression of ANKRD37 mRNA

NCBI chr16:46,268,933...46,271,971
Ensembl chr16:46,268,443...46,271,963

G

alanyl aminopeptidase, membrane

decreases activity
multiple interactions

ISO

1,10-phenanthroline results in decreased activity of ANPEP protein
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]

NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789

G

aquaporin 3 (Gill blood group)

decreases expression

ISO

1,10-phenanthroline results in decreased expression of AQP3 mRNA

NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:56,239,201...56,244,720

G

aspartoacylase

decreases activity

ISO

1,10-phenanthroline results in decreased activity of ASPA protein

NCBI chr10:58,390,204...58,443,790
Ensembl chr10:57,892,104...57,945,272

G

activating transcription factor 6

multiple interactions

ISO

[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2 interacting protein 3 like

decreases expression

ISO

1,10-phenanthroline results in decreased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:41,174,594...41,197,803

G

carbonic anhydrase 9

increases expression

ISO

1,10-phenanthroline results in increased expression of CA9 mRNA

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:57,763,206...57,769,838

G

catalase

decreases expression

ISO

1,10-phenanthroline results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

CD83 molecule

increases expression

ISO

1,10-phenanthroline results in increased expression of CD83 mRNA

NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083

G

CD86 molecule

increases expression
multiple interactions

ISO

1,10-phenanthroline results in increased expression of CD86 mRNA
Acetylcysteine inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]; SB 203580 inhibits the reaction [1,10-phenanthroline results in increased expression of CD86 mRNA]

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

CF transmembrane conductance regulator

increases activity

ISO

1,10-phenanthroline results in increased activity of CFTR protein

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases stability

ISO
EXP

1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [1,10-phenanthroline co-treated with cupric chloride] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; ferric chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; zinc chloride inhibits the reaction [1,10-phenanthroline inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]
[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA
1,10-phenanthroline inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]]
1,10-phenanthroline results in increased stability of CYP1A1 mRNA

PMID:1322109 PMID:19896525 PMID:27180721

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

egl-9 family hypoxia-inducible factor 1

increases expression

ISO

1,10-phenanthroline results in increased expression of EGLN1 mRNA

NCBI chr19:69,765,276...69,804,681
Ensembl chr19:52,869,486...52,907,777

G

egl-9 family hypoxia-inducible factor 2

decreases expression

ISO

1,10-phenanthroline results in decreased expression of EGLN2 mRNA

NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751

G

early growth response 1

increases expression

ISO

1,10-phenanthroline results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

enolase 1

increases expression

ISO

1,10-phenanthroline results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

enolase 2

increases expression

ISO

1,10-phenanthroline results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980

G

ERCC excision repair 2, TFIIH core complex helicase subunit

decreases expression

ISO

1,10-phenanthroline results in decreased expression of ERCC2 mRNA

NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

ISO

1,10-phenanthroline results in increased expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

glutathione peroxidase 3

decreases expression

ISO

1,10-phenanthroline results in decreased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035

G

H2A.X variant histone

multiple interactions

ISO

[Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AX protein modified form

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hepcidin antimicrobial peptide

decreases expression

ISO

1,10-phenanthroline results in decreased expression of HAMP mRNA

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891

G

heparin-binding EGF-like growth factor

increases expression

ISO

1,10-phenanthroline results in increased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases activity

ISO

4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]
1,10-phenanthroline results in increased activity of HIF1A protein

PMID:19091749 PMID:19502547

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible factor 3 subunit alpha

decreases expression

ISO

1,10-phenanthroline results in decreased expression of HIF3A mRNA

NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758

G

hypoxia inducible lipid droplet-associated

increases expression

ISO

1,10-phenanthroline results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

hexokinase 1

increases expression

ISO

1,10-phenanthroline results in increased expression of HK1 mRNA

NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,230,486...30,332,131

G

hexokinase 2

increases expression

ISO

1,10-phenanthroline results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530

G

heme oxygenase 1

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of HMOX1 protein]; 1,10-phenanthroline inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; 1,10-phenanthroline inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]

PMID:9747510 PMID:15629867 PMID:20888885

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

multiple interactions

ISO

1,10-phenanthroline affects the reaction [Smoke results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor binding protein 5

decreases degradation

EXP

1,10-phenanthroline results in decreased degradation of IGFBP5 protein

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

interleukin 1 receptor type 1

decreases expression

ISO

1,10-phenanthroline results in decreased expression of IL1R1 mRNA

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937

G

laminin subunit gamma 2

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [Mustard Gas results in increased degradation of LAMC2 protein]

NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200

G

lactate dehydrogenase A

increases expression

ISO

1,10-phenanthroline results in increased expression of LDHA mRNA

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472

G

membrane-bound transcription factor peptidase, site 2

multiple interactions

ISO

[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of ATF6 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein

NCBI chr X:37,410,914...37,461,130
Ensembl chr X:37,410,811...37,464,430

G

MDM2 proto-oncogene

increases expression

ISO

1,10-phenanthroline results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

macrophage migration inhibitory factor

increases expression

ISO

1,10-phenanthroline results in increased expression of MIF mRNA

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

matrix metallopeptidase 8

decreases activity

ISO

1,10-phenanthroline results in decreased activity of MMP8 protein

NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520

G

matrix metallopeptidase 9

multiple interactions

ISO
EXP

1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]
1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]

PMID:20177776 PMID:20195827

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

neurolysin

decreases activity

EXP

1,10-phenanthroline decreases activity of Nln protein

RGD

NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914

G

natriuretic peptide B

increases expression

ISO

1,10-phenanthroline results in increased expression of NPPB mRNA

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168

G

negative regulator of ubiquitin-like proteins 1

increases expression

ISO

1,10-phenanthroline results in increased expression of NUB1 mRNA

NCBI chr 4:11,335,376...11,366,263
Ensembl chr 4:10,442,917...10,473,694

G

occludin

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [Patulin results in increased degradation of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150

G

prolyl 4-hydroxylase subunit alpha 2

increases expression

ISO

1,10-phenanthroline results in increased expression of P4HA2 mRNA

NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314

G

pyruvate dehydrogenase kinase 1

increases expression

ISO

1,10-phenanthroline results in increased expression of PDK1 mRNA

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 3

increases expression

ISO

1,10-phenanthroline results in increased expression of PDK3 mRNA

NCBI chr X:62,480,535...62,547,371
Ensembl chr X:58,486,554...58,553,557

G

phosphoglycerate kinase 1

increases expression

ISO

1,10-phenanthroline results in increased expression of PGK1 mRNA

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:71,271,440...71,287,418

G

plasminogen activator, urokinase

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

increases expression

ISO

1,10-phenanthroline results in increased expression of PLOD3 mRNA

NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960

G

protein phosphatase 2 scaffold subunit A beta

decreases expression

ISO

1,10-phenanthroline results in decreased expression of PPP2R1B mRNA

NCBI chr 8:60,092,540...60,125,512
Ensembl chr 8:51,186,717...51,228,485

G

phosphoserine phosphatase

decreases expression

ISO

1,10-phenanthroline results in decreased expression of PSPH mRNA

NCBI chr12:26,882,524...26,905,084
Ensembl chr12:26,883,133...26,905,074

G

selectin E

multiple interactions

ISO

1,10-phenanthroline affects the reaction [Smoke results in increased expression of SELE protein]

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741

G

serpin family E member 1

increases expression

ISO

1,10-phenanthroline results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

superoxide dismutase 1

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [9,10-phenanthrenequinone results in decreased expression of SOD1 protein]; 1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in decreased expression of SOD1 protein]

PMID:15629867 PMID:20674559

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [[Hydrogen Peroxide co-treated with Nitroprusside] results in increased expression of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

[1,10-phenanthroline results in decreased activity of MBTPS2 protein] which affects the localization of SREBF1 protein; [1,10-phenanthroline results in decreased activity of MBTPS2 protein] which results in decreased cleavage of SREBF1 protein

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

signal transducer and activator of transcription 3

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

transferrin receptor

increases expression

ISO

1,10-phenanthroline results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

translocase of inner mitochondrial membrane 17A

multiple interactions

ISO

1,10-phenanthroline inhibits the reaction [Adenosine Triphosphate results in decreased expression of TIMM17A protein]

NCBI chr13:46,731,117...46,742,604
Ensembl chr13:46,730,660...46,742,655

G

tumor protein p53

affects folding
affects activity

ISO

1,10-phenanthroline affects the folding of TRP53 protein
1,10-phenanthroline analog affects the activity of TP53 protein

PMID:8467489 PMID:35435491

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

vascular endothelial growth factor A

increases expression
multiple interactions

ISO

1,10-phenanthroline results in increased expression of VEGFA mRNA; 1,10-phenanthroline results in increased expression of VEGFA protein
HIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

bathocuproine disulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin, beta

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACTB mRNA]

NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877

G

Rho GDP dissociation inhibitor alpha

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

G

activating transcription factor 4

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATF4 mRNA]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

antioxidant 1 copper chaperone

multiple interactions

ISO

ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein]

NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950

G

ATPase copper transporting alpha

multiple interactions

ISO

[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]]

PMID:11092760 PMID:21242307

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354

G

ATPase copper transporting beta

multiple interactions

ISO

[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636

G

BCL2, apoptosis regulator

decreases expression

ISO

bathocuproine sulfonate results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of BCL2A1 mRNA]]

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998

G

caspase 3

multiple interactions

EXP

bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of CASP3 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of CASP3 protein]

PMID:10941151 PMID:11239917 PMID:18056745

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CASP8 mRNA]]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

C-C motif chemokine ligand 2

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCL3 mRNA]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

chaperonin containing TCP1 subunit 5

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CCT5 mRNA]]

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

Cd200 molecule

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

CD44 molecule

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA]

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

cadherin 17

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CDH17 mRNA]; [pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CDH17 mRNA

NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:25,262,758...25,314,884

G

clusterin

multiple interactions

ISO

[Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315

G

contactin associated protein 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CNTNAP1 mRNA

NCBI chr10:86,610,140...86,625,896
Ensembl chr10:86,111,643...86,125,611

G

catechol-O-methyltransferase

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of COMT mRNA]

NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642

G

ceruloplasmin

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in increased expression of CP protein]

NCBI chr 2:104,368,336...104,427,119
Ensembl chr 2:102,439,624...102,498,075

G

cleavage and polyadenylation specific factor 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CPSF1 mRNA

NCBI chr 7:108,319,429...108,330,018
Ensembl chr 7:108,319,434...108,329,934

G

cAMP responsive element binding protein 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of CREB1 mRNA

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element modulator

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CREM mRNA]

NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989

G

cullin 5

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA]

NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666

G

cytochrome c, somatic

multiple interactions

EXP

bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which affects the localization of CYCS protein]

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458

G

dual specificity phosphatase 4

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of DUSP4 mRNA]]

NCBI chr16:64,079,893...64,101,396
Ensembl chr16:57,377,229...57,398,138

G

early growth response 2

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of EGR2 mRNA]

NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of EGR3 mRNA

NCBI chr15:51,560,482...51,565,778
Ensembl chr15:45,150,567...45,154,627

G

fatty acid synthase

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of FASN mRNA]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor 2

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]; bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FOS protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]

PMID:15477007 PMID:17032174

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FYN binding protein 1

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of FYB1 mRNA]

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

GDNF family receptor alpha 2

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GFRA2 mRNA]

NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714

G

GNAS complex locus

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

general transcription factor IIH subunit 2

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of GTF2H2C mRNA

NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HADHA mRNA]

NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869

G

HCK proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]

NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:141,571,587...141,614,693

G

heme oxygenase 1

multiple interactions

ISO

[Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

heterogeneous nuclear ribonucleoprotein U-like 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HNRNPUL1 mRNA

NCBI chr 1:81,228,404...81,264,121
Ensembl chr 1:81,228,404...81,262,592

G

hemopexin

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

heat shock protein family A (Hsp70) member 8

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HSPA8 mRNA; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPA8 mRNA]]

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259

G

hyaluronidase 3

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of HYAL3 mRNA

NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647

G

interleukin 2

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 2 receptor subunit alpha

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein]]

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697

G

interleukin 2 receptor subunit beta

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RB mRNA]

NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:110,033,341...110,048,054

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[JUN protein binds to FOS protein] which results in increased expression of and results in increased activity of CP protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN protein]]

PMID:15477007 PMID:17032174

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

lymphocyte cytosolic protein 1

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of LCP1 mRNA]

NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680

G

low density lipoprotein receptor

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [copper histidine results in increased expression of LDLR mRNA]

NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580

G

latent transforming growth factor beta binding protein 4

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of LTBP4 mRNA]

NCBI chr 1:91,727,769...91,759,822
Ensembl chr 1:82,600,136...82,632,178

G

mitogen activated protein kinase 1

multiple interactions

ISO
EXP

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK1 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]
bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]

PMID:10658192 PMID:15477007 PMID:22842628

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

ISO
EXP

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased phosphorylation of MAPK3 protein]]
bathocuproine sulfonate inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]
bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK3 protein]

PMID:10941151 PMID:15477007 PMID:22842628

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

EXP

bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[Disulfiram binds to cupric chloride] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK8 protein]

PMID:10941151 PMID:11239917 PMID:18056745

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

metallothionein 1, pseudogene 3

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135

G

metastasis associated 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MTA1 mRNA

NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641

G

metal-regulatory transcription factor 1

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] affects the localization of MTF1 protein]; bathocuproine sulfonate inhibits the reaction [[cobaltiprotoporphyrin co-treated with HPX protein] results in increased expression of MTF1 mRNA]; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MYC mRNA]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

N(alpha)-acetyltransferase 80, NatH catalytic subunit

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of NAA80 mRNA]

NCBI chr 8:117,132,957...117,136,207
Ensembl chr 8:108,253,302...108,257,563

G

neural EGFL like 1

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NELL1 mRNA]

NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

N-myc (and STAT) interactor

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NMI mRNA]

NCBI chr 3:36,415,607...36,439,716
Ensembl chr 3:36,415,607...36,439,498

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of NR4A3 mRNA]

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733

G

ornithine decarboxylase 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

paired box 8

multiple interactions

EXP

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of PAX8 mRNA]

NCBI chr 3:27,584,000...27,641,094
Ensembl chr 3:7,185,723...7,242,363

G

proliferating cell nuclear antigen

decreases expression

ISO

bathocuproine sulfonate results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

protein phosphatase 1, regulatory subunit 10

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of PPP1R10 mRNA

NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,822,995...2,837,611

G

prion protein

multiple interactions

EXP

bathocuproine sulfonate inhibits the reaction [cupric chloride results in increased expression of PRNP protein]

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:119,177,485...119,203,937

G

REL proto-oncogene, NF-kB subunit

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of REL mRNA]

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

synthesis of cytochrome C oxidase 1

increases oxidation

ISO

bathocuproine sulfonate results in increased oxidation of SCO1 protein

NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237

G

src-like adaptor

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SLA mRNA]

NCBI chr 7:98,534,431...98,584,810
Ensembl chr 7:98,535,368...98,584,648

G

solute carrier family 31 member 1

multiple interactions

ISO

[bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA; bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]

NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228

G

solute carrier family 31 member 2

multiple interactions
affects localization

ISO

[[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein] which results in increased uptake of and results in increased susceptibility to Cisplatin; [bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein
bathocuproine sulfonate affects the localization of SLC31A2 protein
ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 mRNA]; ATOX1 protein affects the reaction [[bathocuproine sulfonate results in decreased abundance of Copper] which results in decreased expression of SLC31A2 protein]

NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542

G

small nuclear ribonucleoprotein U1 subunit 70

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SNRNP70 mRNA

NCBI chr 1:104,992,518...105,012,851
Ensembl chr 1:95,856,036...95,876,392

G

superoxide dismutase 1

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

Sp1 transcription factor

multiple interactions

ISO

bathocuproine sulfonate promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

serglycin

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of SRGN mRNA

NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406

G

SRP receptor subunit alpha

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SRPRA mRNA]

NCBI chr 8:41,818,199...41,824,292
Ensembl chr 8:33,560,348...33,566,470

G

tumor necrosis factor

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1B

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TNFRSF1B mRNA]

NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206

G

tumor protein p53

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid results in increased abundance of Copper] which results in increased oxidation of and results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

thyroid peroxidase

multiple interactions

EXP

bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased expression of TPO mRNA]

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:46,698,414...46,768,199

G

TNF receptor-associated factor 1

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]; bathocuproine sulfonate inhibits the reaction [pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TRAF1 mRNA]]

NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807

G

tyrosinase

multiple interactions

ISO

bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]; cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]]

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

transmembrane immune signaling adaptor Tyrobp

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TYROBP mRNA]

NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848

G

ubiquitin-conjugating enzyme E2L 6

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBE2L6 mRNA

NCBI chr 3:90,279,705...90,294,721
Ensembl chr 3:69,873,424...69,888,048

G

ubiquitin-like 4A

multiple interactions

ISO

[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of UBL4A mRNA

NCBI chr X:152,151,242...152,154,094
Ensembl chr X:152,151,460...152,154,069

G

vimentin

multiple interactions

ISO

[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of VIM mRNA]

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin E1

decreases expression

EXP

BKM120 decreases expression of cyclin E protein in rat pituitary tumor cell line

RGD

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

prolactin

decreases expression

EXP

BKM120 decreases expression of prolactin protein in serum of treated rats

RGD

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

copanlisib results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

Fas cell surface death receptor

affects response to substance

ISO

copanlisib affects the susceptibility to FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

tumor necrosis factor

increases response to substance

ISO

copanlisib results in increased susceptibility to TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases expression
increases phosphorylation
decreases phosphorylation
multiple interactions

ISO
EXP

dactolisib results in decreased expression of AKT1 protein modified form
dactolisib increases phosphorylation of Akt in rat tumor grafts
dactolisib results in decreased phosphorylation of AKT1 protein
dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]
dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]

CTD
RGD

PMID:19435893 PMID:21464613 PMID:22415236 PMID:22949526 PMID:23151917 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib affects the folding of and results in increased activity of BAX protein; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

Bcl2-like 1

affects expression

ISO

dactolisib affects the expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

affects expression

ISO

dactolisib affects the expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

baculoviral IAP repeat-containing 5

decreases expression

ISO

dactolisib results in decreased expression of BIRC5 protein

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

increases activity
multiple interactions
increases cleavage

ISO

dactolisib results in increased activity of CASP3 protein
Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]

PMID:21372221 PMID:23151917

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions
increases cleavage

ISO

Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein]

Ensembl chr 5:154,109,046...154,126,626

G

cyclin D1

decreases phosphorylation

ISO

dactolisib results in decreased phosphorylation of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

dactolisib results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cathepsin B

affects localization
multiple interactions

ISO

dactolisib affects the localization of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500

G

epidermal growth factor

multiple interactions

ISO

dactolisib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation
multiple interactions
increases response to substance

ISO

dactolisib results in decreased phosphorylation of EIF4EBP1 protein
Ku 0063794 inhibits the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]; mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of EIF4EBP1 protein]
EIF4EBP1 protein modified form results in increased susceptibility to dactolisib

PMID:21372221 PMID:22415236 PMID:23151917 PMID:25640480

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

heat shock transcription factor 1

decreases activity

ISO

dactolisib results in decreased activity of HSF1 protein

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

insulin 1

multiple interactions

ISO

dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]; dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536

G

leptin receptor

multiple interactions

ISO

LEPR affects the reaction [dactolisib results in decreased phosphorylation of AKT1 protein]

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908

G

microtubule-associated protein 1 light chain 3 alpha

increases metabolic processing
affects localization

ISO

dactolisib results in increased metabolism of MAP1LC3A protein
dactolisib affects the localization of MAP1LC3A protein

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

mitogen activated protein kinase 1

multiple interactions

ISO

dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

ISO

dactolisib promotes the reaction [mirdametinib results in decreased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

affects expression
multiple interactions

ISO

dactolisib affects the expression of MCL1 protein
[dactolisib co-treated with (+)-JQ1 compound] affects the expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

O-linked N-acetylglucosamine (GlcNAc) transferase

increases response to substance

ISO

OGT mutant form results in increased susceptibility to dactolisib

NCBI chr X:70,811,317...70,856,123
Ensembl chr X:66,771,349...66,816,146

G

oxidative stress responsive kinase 1

multiple interactions
decreases phosphorylation

ISO

dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of OXSR1 protein]
dactolisib results in decreased phosphorylation of OXSR1 protein

NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

dactolisib results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases response to substance
decreases response to substance

ISO

PIK3CA results in increased susceptibility to dactolisib
PIK3CA results in decreased susceptibility to dactolisib

PMID:21372221 PMID:21633166

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

phosphatase and tensin homolog

increases response to substance

ISO

PTEN gene mutant form results in increased susceptibility to dactolisib

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

RB transcriptional corepressor 1

decreases expression

ISO

dactolisib results in decreased expression of RB1 protein modified form

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

ISO

mirdametinib promotes the reaction [dactolisib results in decreased phosphorylation of RPS6 protein]

PMID:21372221 PMID:21464613 PMID:21498705 PMID:22415236 PMID:23151917 More...

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases phosphorylation

ISO

dactolisib results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

solute carrier family 12 member 3

multiple interactions
decreases phosphorylation

ISO

dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of SLC12A3 protein]
dactolisib results in decreased phosphorylation of SLC12A3 protein

NCBI chr19:10,636,594...10,690,008
Ensembl chr19:10,631,393...10,669,091

G

sequestosome 1

multiple interactions
decreases expression

ISO

bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]

PMID:23151917 PMID:23651616

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

serine threonine kinase 39

multiple interactions
decreases phosphorylation

ISO

dactolisib inhibits the reaction [INS1 protein results in increased phosphorylation of STK39 protein]
dactolisib results in decreased phosphorylation of STK39 protein

NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

eukaryotic translation elongation factor 1 alpha 1

affects binding

EXP

Gamendazole binds to Eef1a1 protein

RGD

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

G

heat shock protein 90 alpha family class B member 1

affects binding

EXP

gamendazole binds to Hsp90ab1 protein

RGD

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]
IC 87114 results in decreased phosphorylation of AKT1 protein

PMID:16179367 PMID:19176369

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

colony stimulating factor 2

multiple interactions

ISO

IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

forkhead box O3

multiple interactions
decreases phosphorylation

ISO

IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]
IC 87114 results in decreased phosphorylation of FOXO3 protein

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

glycogen synthase kinase 3 alpha

decreases phosphorylation

ISO

IC 87114 results in decreased phosphorylation of GSK3A protein

NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

decreases phosphorylation

ISO

IC 87114 results in decreased phosphorylation of GSK3B protein

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

interleukin 10

multiple interactions

ISO

IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased secretion of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

multiple interactions

ISO

IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 4

multiple interactions

ISO

IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]

PMID:16179367 PMID:33711354

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 5

multiple interactions

ISO

IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL5 protein]

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213

G

interleukin 6

multiple interactions

ISO

IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

ISO

IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]
IC 87114 results in decreased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

ISO

IC 87114 inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]
IC 87114 results in decreased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases activity
multiple interactions

ISO

IC 87114 results in decreased activity of PIK3CD protein
IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CD protein]

PMID:16179367 PMID:33711354

NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

multiple interactions

ISO

IC 87114 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of PIK3CG protein]

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

protein tyrosine phosphatase, non-receptor type 11

multiple interactions
increases response to substance

ISO

IC 87114 inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]
PTPN11 protein mutant form results in increased susceptibility to IC 87114

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925

G

ribosomal protein S6 kinase B1

decreases phosphorylation

ISO

IC 87114 results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; AKT activator SC79 inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; palbociclib promotes the reaction [idelalisib results in decreased phosphorylation of AKT1 protein]

PMID:23676220 PMID:31445927

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

ISO

[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

ISO

[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

multiple interactions

ISO

[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

multiple interactions

ISO

[palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

ISO

[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]; AKT activator SC79 inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

CASP8 and FADD-like apoptosis regulator

multiple interactions

ISO

[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034

G

C-X-C motif chemokine ligand 1

decreases expression

ISO

idelalisib decreases expression of Cxcl1 protein in liver and spleen

RGD

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

Fas cell surface death receptor

affects response to substance
multiple interactions

ISO

idelalisib affects the susceptibility to FAS protein
FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

ISO

[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein; [FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein; [FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein; [idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2 protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of BCL2L1 protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased cleavage of BID protein]; AKT activator SC79 inhibits the reaction [[FASLG protein co-treated with idelalisib] results in increased expression of and affects the localization of BAX protein]; AKT activator SC79 inhibits the reaction [[idelalisib co-treated with FASLG protein] results in decreased phosphorylation of AKT1 protein]; AKT activator SC79 inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; AKT activator SC79 inhibits the reaction [idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]]; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]; idelalisib promotes the reaction [FASLG protein results in increased cleavage of CASP8 protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

glutamic--pyruvic transaminase

multiple interactions
affects expression
increases expression

ISO

[Galactosamine co-treated with Lipopolysaccharides] promotes the reaction [idelalisib results in increased expression of ALT protein]; FAS protein affects the reaction [idelalisib results in increased expression of ALT protein]
idelalisib affects the expression of GPT protein

PMID:31445927 PMID:31501888

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

ISO

idelalisib results in increased expression of HIF1A protein
idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein]

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

interferon gamma

decreases expression

ISO

idelalisib decreases expression of Ifng protein in liver, spleen and lymph node

RGD

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

decreases expression

ISO

idelalisib decreases expression of Il10 protein in liver, lymph node and spleen

RGD

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 4

decreases expression

ISO

idelalisib decreases expression of Il4 protein in lymph node

RGD

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

decreases expression

ISO

idelalisib decreases expression of Il6 protein in liver and spleen

RGD

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

microRNA 122

affects expression

ISO

idelalisib affects the expression of MIR122 mRNA

NCBI chr18:58,758,703...58,758,787

G

matrix metallopeptidase 9

multiple interactions
decreases expression

ISO

idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
idelalisib results in decreased expression of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

idelalisib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]
idelalisib inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]; idelalisib promotes the reaction [Lipopolysaccharides results in increased expression of MTOR mRNA]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

N-acetyltransferase 10

increases expression

ISO

idelalisib results in increased expression of NAT10 mRNA

NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:90,111,645...90,149,927

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

[palbociclib results in increased susceptibility to idelalisib] which results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases expression
multiple interactions

ISO

idelalisib results in increased expression of PIK3CA mRNA
idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

increases expression
multiple interactions

ISO

idelalisib results in increased expression of PIK3CB mRNA
idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

multiple interactions
increases expression

ISO

idelalisib inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]
idelalisib results in increased expression of PIK3CD mRNA

NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

decreases expression

ISO

idelalisib results in decreased expression of PIK3CG mRNA

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase interacting protein 1

increases expression

ISO

idelalisib results in increased expression of PIK3IP1 mRNA

NCBI chr14:82,428,315...82,440,261
Ensembl chr14:78,204,053...78,216,608

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

AKT activator SC79 inhibits the reaction [idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]]; idelalisib inhibits the reaction [FASLG protein results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

transforming growth factor, beta 1

multiple interactions

ISO

idelalisib inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]; idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]; idelalisib inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases response to substance
multiple interactions

ISO

idelalisib results in increased susceptibility to TNF protein
[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein; [TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in decreased expression of CFLAR protein]; AKT activator SC79 inhibits the reaction [[TNF protein co-treated with idelalisib] results in increased activity of CASP8 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

multiple interactions

ISO

idelalisib promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]
idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; idelalisib inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

ISO

arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of AKT1 protein]; lonidamine promotes the reaction [Curcumin results in decreased phosphorylation of AKT1 protein]

PMID:20605902 PMID:21889928

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aquaporin 9

multiple interactions

EXP

lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

BCL2 associated X, apoptosis regulator

affects localization
multiple interactions

ISO

lonidamine affects the localization of BAX protein
Curcumin promotes the reaction [lonidamine affects the localization of BAX protein]; lonidamine promotes the reaction [Curcumin affects the localization of BAX protein]

PMID:20605902 PMID:21889928

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

ISO

BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

ISO

lonidamine results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

increases activity
multiple interactions

ISO

lonidamine results in increased activity of BID protein
[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of BID protein

PMID:20605902 PMID:21889928

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

caspase 1

multiple interactions

ISO

lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of CASP1 protein]; lonidamine inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased cleavage of CASP1 protein]; lonidamine inhibits the reaction [Poly dA-dT results in increased cleavage of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

ISO

[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP3 protein; [Curcumin co-treated with lonidamine] results in increased cleavage of CASP3 protein

PMID:20605902 PMID:21889928

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

ISO

[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein; BCL2 protein inhibits the reaction [[arsenic trioxide co-treated with lonidamine] results in increased cleavage of and results in increased activity of CASP8 protein]

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

ISO

[Curcumin co-treated with lonidamine] results in increased cleavage of CASP9 protein; arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [arsenic trioxide promotes the reaction [lonidamine results in increased cleavage of and results in increased activity of CASP9 protein]]; BCL2 protein inhibits the reaction [lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]]; lonidamine promotes the reaction [arsenic trioxide results in increased cleavage of and results in increased activity of CASP9 protein]; lonidamine results in increased cleavage of and results in increased activity of CASP9 protein

PMID:20605902 PMID:21889928

Ensembl chr 5:154,109,046...154,126,626

G

CF transmembrane conductance regulator

decreases activity
multiple interactions

ISO
EXP

lonidamine results in decreased activity of CFTR protein
lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]

PMID:12606488 PMID:15634668

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

gasdermin D

multiple interactions

ISO

lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased cleavage of GSDMD protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of GSDMD protein]

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

HtrA serine peptidase 2

multiple interactions

ISO

[lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein

NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:115,556,916...115,560,095

G

interleukin 18

multiple interactions

ISO

lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of IL18 protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

ISO

lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] results in increased secretion of and affects the cleavage of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Imiquimod] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Nigericin] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Uric Acid] results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] results in increased expression of IL1B protein]; lonidamine inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased secretion of IL1B protein]; lonidamine inhibits the reaction [Poly dA-dT results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

ISO

lonidamine results in decreased expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

PYD and CARD domain containing

affects binding
multiple interactions

ISO

lonidamine binds to PYCARD protein
lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to CASP1 protein]]; lonidamine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Adenosine Triphosphate] promotes the reaction [PYCARD protein binds to PYCARD protein]]; lonidamine inhibits the reaction [[myelin oligodendrocyte glycoprotein (35-55) co-treated with Freund's Adjuvant co-treated with Pertussis Toxin co-treated with betadex] inhibits the reaction [PYCARD protein binds to PYCARD protein]]

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955

G

ribosomal protein S6

multiple interactions
increases phosphorylation

ISO

arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6 protein]

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

multiple interactions
increases phosphorylation

ISO

arsenic trioxide inhibits the reaction [lonidamine results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

serine/threonine kinase 11

increases phosphorylation

ISO

lonidamine results in increased phosphorylation of STK11 protein

NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315

G

testin gene

multiple interactions
increases secretion
increases expression

EXP

adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Cycloheximide inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Cycloheximide inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]; Dactinomycin inhibits the reaction [lonidamine results in increased expression of TESTIN mRNA]; Dactinomycin inhibits the reaction [lonidamine results in increased secretion of TESTIN protein]; lonidamine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of TESTIN mRNA]; lonidamine inhibits the reaction [Bucladesine results in decreased expression of TESTIN mRNA]
lonidamine results in increased expression of TESTIN; lonidamine results in increased expression of TESTIN mRNA

NCBI chr17:3,829,012...3,864,995
Ensembl chr17:3,846,899...3,859,385

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

ISO

arsenic trioxide promotes the reaction [lonidamine results in decreased expression of XIAP protein]; Curcumin promotes the reaction [lonidamine results in decreased expression of XIAP protein]; lonidamine promotes the reaction [arsenic trioxide results in decreased expression of XIAP protein]; lonidamine promotes the reaction [Curcumin results in decreased expression of XIAP protein]

PMID:20605902 PMID:21889928

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 protein

PMID:23466342 PMID:27888070

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1B protein

NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

decreases expression

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of ABCC2 mRNA]

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 5

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC5 protein

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily G member 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein]

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065

G

actin alpha 2, smooth muscle

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of ACTA2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of ACTA2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of ACTA2 protein]

PMID:33895847 PMID:39353502

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

activin A receptor type 2B

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA]

NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458

G

adiponectin, C1Q and collagen domain containing

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

adenosine A2B receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of and results in decreased activity of GPX4 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of SLC7A11 protein]]

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

adrenoceptor alpha 1A

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]

NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]

PMID:15121739 PMID:16325820 PMID:23300732 PMID:25398788

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

increases expression
multiple interactions
decreases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AHR mRNA

PMID:22406437 PMID:27020609

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1 member B1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]

NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKR1B10 protein

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [panaxytriol results in increased activity of AKR1C2 protein]

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [panaxytriol results in increased activity of AKR1C3 protein]

PMID:18826220 PMID:21787718

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

increases expression
decreases reaction
decreases phosphorylation
multiple interactions
decreases expression
decreases activity

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AKT1 protein
LY294002 inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Glucose co-treated with Calcitriol] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [VEGFC protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of and results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with intybin] results in increased phosphorylation of AKT1 protein; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hemistepsin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [quinocetone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Estradiol] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of AKT1 protein]; [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Formaldehyde co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [IGF1 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [sodium arsenite co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Cisplatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-aminoisoquinolinone co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Capsaicin co-treated with Oxygen deficiency co-treated with Oxygen] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [diallyl trisulfide inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [wendan inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of AKT1 protein; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 protein

CTD
RGD

PMID:11306697 PMID:11788791 PMID:12438947 PMID:12511591 PMID:12556562 More...

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT1 substrate 1

decreases phosphorylation

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of ALPL protein]]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446

G

angiopoietin 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein results in decreased susceptibility to Doxorubicin]

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:73,531,486...73,784,067

G

angiopoietin 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of MKI67 protein]

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

G

apelin

increases expression
multiple interactions
increases secretion

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of APLN mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Eicosapentaenoic Acid results in increased expression of APLN mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased secretion of APLN protein

PMID:20352620 PMID:21461750

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

G

amyloid beta precursor protein

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of and affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxyphylla A inhibits the reaction [APP protein results in increased abundance of amyloid beta-protein (1-40)]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in increased activity of CASP3 protein]

PMID:16648635 PMID:19741129 PMID:22186599 PMID:28756148 PMID:35024177

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 3 (Gill blood group)

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein]

PMID:16848764 PMID:18214481

NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:56,239,201...56,244,720

G

aquaporin 9

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in decreased expression of AQP9 mRNA]

NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395

G

androgen receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methoxyacetic acid promotes the reaction [Testosterone results in increased activity of AR protein]]

PMID:16472761 PMID:18486176 PMID:19059400

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925

G

arginase 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of ARG2 protein]

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

activating transcription factor 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]; Cycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]; SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions

ISO
EXP

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]]

PMID:24898257 PMID:31433112

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 5

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209

G

autophagy related 7

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593

G

ATM serine/threonine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

aurora kinase B

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AURKB protein

NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837

G

axin 2

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased expression of AXIN2 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AXIN2 mRNA

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231

G

BCL2-associated agonist of cell death

multiple interactions
decreases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in decreased activity of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of BAD protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of BAD protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of BAD protein]

PMID:12438947 PMID:12970779 PMID:14628071 PMID:17123556 PMID:17293559 More...

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

affects localization
increases expression
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in increased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Stilbenes analog affects the localization of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased expression of BAX protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with arsenic disulfide] results in increased expression of BAX protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with TNFSF10 protein] results in increased activity of BAX protein; [Arsenic Trioxide co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of BAX protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]

PMID:15665116 PMID:15942663 PMID:18449500 PMID:20097879 PMID:20386985 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions
increases expression

ISO
EXP

[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BBC3 protein

PMID:20856197 PMID:24567336

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
increases expression
increases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of BCL2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with arsenic disulfide] results in decreased expression of BCL2 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; BCL2 protein results in decreased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BCL2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of BCL2 protein

PMID:16018989 PMID:20386985 PMID:20856197 PMID:21130731 PMID:21800153 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of BCL2A1 mRNA]

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

multiple interactions
decreases expression
increases degradation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in increased expression of BCL2L1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 protein; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of BCL2L1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BCL2L1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]

PMID:14762343 PMID:17293559 PMID:18789402 PMID:21173233 PMID:21821001 More...

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

multiple interactions
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in decreased expression of BCL2L11 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased phosphorylation of BCL2L11 protein; Resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BCL2L11 protein alternative form]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of BCL2L11 protein]]

PMID:20856197 PMID:21179458 PMID:25471227 PMID:29054700

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

BCR activator of RhoGEF and GTPase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]

NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,471,668...13,597,016

G

bradykinin receptor B1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1A protein results in increased expression of BDKRB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BDKRB1 protein]

NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747

G

brain-derived neurotrophic factor

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased chemical synthesis of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased expression of BDNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased secretion of BDNF protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]

PMID:15287886 PMID:17172126 PMID:17209049 PMID:19962417 PMID:29061316

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions
increases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BECN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in increased expression of BECN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of BECN1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BECN1 protein

PMID:25955216 PMID:30726812 PMID:33450223 PMID:35568058 PMID:36343798 More...

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]]

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495

G

BH3 interacting domain death agonist

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]

PMID:20856197 PMID:27032576

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 2

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC2 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of BIRC2 mRNA]

PMID:12970779 PMID:14762343 PMID:15065019 PMID:16256798 PMID:19596284

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC3 protein

PMID:12970779 PMID:14762343 PMID:15339911 PMID:19596284

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in increased expression of BIRC5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased expression of BIRC5 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 protein; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BIRC5 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]

PMID:15065019 PMID:16222118 PMID:17472962 PMID:17548900 PMID:18606715 More...

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

bone morphogenetic protein 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397

G

betacellulin

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein]

NCBI chr14:16,992,668...17,031,178
Ensembl chr14:16,707,982...16,747,049

G

calcitonin-related polypeptide alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in decreased susceptibility to Etoposide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in increased expression of BIRC5 protein]

NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105

G

cathelicidin antimicrobial peptide

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CAMP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

G

carbonic anhydrase 9

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:57,763,206...57,769,838

G

caspase 1

multiple interactions
increases cleavage

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased cleavage of CASP1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of CASP1 protein]]
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased cleavage of CASP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP1 protein

PMID:25929181 PMID:30726812 PMID:36898572

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 2

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases cleavage
multiple interactions
increases activity

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in decreased expression of CASP3 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased expression of and results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased activity of and results in increased localization of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of and results in increased activity of CASP3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Gemcitabine] affects the activity of CASP3 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein; [U 0126 co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP3 protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; Boc-D-FMK inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of CASP3 protein

PMID:14687664 PMID:14688022 PMID:15695173 PMID:15850772 PMID:15942663 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]]

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 6

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP6 protein]

PMID:17341418 PMID:19801490

NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502

G

caspase 7

increases activity
increases cleavage
multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP7 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP7 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased activity of CASP7 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP7 protein]

PMID:14687664 PMID:14688022 PMID:16487511 PMID:36252918

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases activity

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP8 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP8 protein]]

PMID:15850772 PMID:15942663 PMID:20856197 PMID:27032576 PMID:33030052

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased activity of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [pachastrissamine analog results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of CASP9 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP9 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased cleavage of CASP9 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]]

PMID:12438947 PMID:15850772 PMID:16412023 PMID:17341418 PMID:19801490 More...

Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in decreased expression of CAT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of CAT protein]

PMID:22040890 PMID:32602595 PMID:35901927

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 11

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]

PMID:16794257 PMID:19293636 PMID:19446813 PMID:20354174 PMID:22225513 More...

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of CCN2 mRNA]]

PMID:26054450 PMID:33270355

NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734

G

cyclin A2

decreases expression
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNA2 protein
[Oxygen deficiency co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of CCNA2 protein; [Oxygen deficiency co-treated with kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CCNA2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNA2 protein]

PMID:14971663 PMID:17148679 PMID:36940862

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CCNB1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CCNB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNB1 mRNA

PMID:32877639 PMID:34677630

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of CCND1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased expression of CCND1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in decreased expression of CCND1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]

PMID:14750165 PMID:14757120 PMID:15695173 PMID:16412023 PMID:17148679 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
decreases expression
decreases methylation
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased methylation of CCND2 promoter
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CCND2 mRNA

PMID:14745455 PMID:15601625 PMID:15778701

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND3 protein

PMID:14757120 PMID:15601625 PMID:15778701

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein

PMID:14757120 PMID:14971663 PMID:15601625

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

C-C motif chemokine receptor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100

G

CD274 molecule

decreases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CD274 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CD274 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [nano-diamino-tetrac results in decreased expression of CD274 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [nano-diamino-tetrac results in decreased expression of CD274 protein]; nano-diamino-tetrac promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CD274 protein]

NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450

G

CD36 molecule

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CD36 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]

PMID:19640849 PMID:25712622

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD38 molecule

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA]

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD44 molecule

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]]

NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620

G

cell division cycle 25C

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CDC25C protein]

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 6

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzalkonium Compounds results in decreased expression of CDC6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cetylpyridinium results in decreased expression of CDC6 protein]

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011

G

cadherin 1

increases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDH1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]

PMID:23921149 PMID:25118938 PMID:25656647 PMID:26089345 PMID:26363213 More...

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]

PMID:24997338 PMID:30609689

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDK1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CDK1 protein]

PMID:32877639 PMID:34677630

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 16

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDK16 mRNA]

NCBI chr X:4,046,330...4,057,825
Ensembl chr X:1,492,814...1,504,148

G

cyclin dependent kinase 2

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of CDK2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]

PMID:34896440 PMID:36940862

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDK4 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]

PMID:27312872 PMID:36940862

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased expression of and affects the localization of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased stability of CDKN1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Resveratrol co-treated with Clofarabine] results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased expression of CDKN1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A protein

PMID:15001399 PMID:15695173 PMID:17148679 PMID:23146690 PMID:25791921 More...

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

ISO

[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA; [resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CDKN1B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1B protein

PMID:11322924 PMID:15601625 PMID:17148679 PMID:18622747 PMID:21179458

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2A mRNA]

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149

G

cyclin dependent kinase inhibitor 2D

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2D mRNA]

NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674

G

caudal type homeo box 2

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA]

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

CCAAT/enhancer binding protein alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CEBPA mRNA]

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CEBPB mRNA]

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473

G

CASP8 and FADD-like apoptosis regulator

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CFLAR protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CFLAR protein alternative form

PMID:12970779 PMID:16434995 PMID:21173233

NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034

G

CF transmembrane conductance regulator

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]

NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions
decreases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of CHUK protein

PMID:18789402 PMID:20386985

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065

G

claudin 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN1 protein]

NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724

G

claudin 2

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:103,459,780...103,474,838

G

claudin 5

multiple interactions
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN5 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in decreased expression of CLDN5 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Sulfide results in decreased expression of CLDN5 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CLDN5 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL6 protein results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in decreased expression of CLDN5 protein]

PMID:20525806 PMID:24200059 PMID:26025059 PMID:28741371 PMID:32404561

NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992

G

collagen type I alpha 1 chain

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of COL1A2 protein]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

collagen type IV alpha 1 chain

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]]

NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412

G

cytochrome c oxidase subunit 4i1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of COX4I1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of COX4I1 protein]

NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921

G

cAMP responsive element binding protein 1

multiple interactions
decreases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of CREB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of CREB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]

PMID:18276108 PMID:19962417 PMID:25605016 PMID:29061316

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

colony stimulating factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]

NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

cardiotrophin 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]

NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:182,328,090...182,333,335

G

catenin beta 1

multiple interactions
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of and results in increased activity of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in decreased phosphorylation of and results in increased activity of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in decreased phosphorylation of and results in increased activity of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in decreased phosphorylation of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased expression of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein]; [Tamoxifen co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects the localization of CTNNB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CTNNB1 protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased stability of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in decreased phosphorylation of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein]

PMID:19814765 PMID:20542495 PMID:22046442 PMID:22859221 PMID:22884995 More...

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of CTSB protein

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of CXCL2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of CXCL2 mRNA]

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

cytochrome c, somatic

affects localization
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of CYCS protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]]

PMID:15942663 PMID:32298737 PMID:34612572

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]

PMID:20096755 PMID:20678559 PMID:28571770

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

dystroglycan 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of DAG1 mRNA]

NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:108,890,929...108,952,325

G

dopachrome tautomerase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of DCT protein]

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836

G

doublecortin

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DCX protein

NCBI chr X:112,227,455...112,370,291
Ensembl chr X:107,430,767...107,507,476

G

DNA-damage inducible transcript 3

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]

PMID:11145585 PMID:17171638 PMID:27658547 PMID:31433112

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DDIT4 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DDIT4 protein

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105

G

diacylglycerol kinase, delta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of DGKD protein alternative form]

NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345

G

discs large MAGUK scaffold protein 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of DLG4]

NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153

G

DNA methyltransferase 3 beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124

G

dipeptidylpeptidase 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]

NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:202,204,693...202,228,541

G

dynein cytoplasmic 1 heavy chain 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of DYNC1H1 mRNA]

NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:129,609,397...129,680,883

G

E2F transcription factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of E2F1 protein]

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

endothelin 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 1 alpha 2

decreases expression
multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of EEF1A2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of EEF1A2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of EEF1A2 protein

PMID:19738051 PMID:37051183

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

epidermal growth factor

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyadox results in increased expression of EGF]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]

PMID:11742803 PMID:15040022 PMID:16343977 PMID:16472761 PMID:16619521 More...

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 2A

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased phosphorylation of EIF2A protein]

NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 4B

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4B protein]

NCBI chr 7:133,206,637...133,228,436

G

eukaryotic translation initiation factor 4E

multiple interactions
decreases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4E protein

PMID:12781867 PMID:26282490

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of EIF4EBP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4EBP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EIF4EBP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]

PMID:12411397 PMID:12569580 PMID:12939469 PMID:14769825 PMID:17148679 More...

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4 gamma 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4G1 protein]

NCBI chr11:93,726,322...93,746,387
Ensembl chr11:80,221,919...80,241,941

G

eukaryotic translation initiation factor 4, gamma 2

increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of EIF4G2 protein

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

G

E1A binding protein p300

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein]

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228

G

erythropoietin

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased susceptibility to Doxorubicin]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in decreased susceptibility to Levodopa]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO results in increased phosphorylation of GSK3B protein]

PMID:17928571 PMID:17952604 PMID:21683736 PMID:21915944 PMID:23384249

NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946

G

erb-b2 receptor tyrosine kinase 2

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Cisplatin]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Doxorubicin]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Paclitaxel]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of ERBB2 mRNA]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ERBB2 mRNA]

PMID:12439862 PMID:21712253 PMID:30205135

NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]

NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525

G

endogenous retrovirus group FRD member 1, envelope

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in decreased expression of ERVFRD-1 protein]

NCBI chr12:27,787,680...27,794,732
Ensembl chr12:22,151,211...22,158,264

G

estrogen receptor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein affects the localization of ESR1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of ESR1]

PMID:15947004 PMID:19661335 PMID:26969072

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

estrogen-related receptor gamma

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG protein]

NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397

G

F11 receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in decreased expression of F11R protein]

NCBI chr13:86,406,229...86,429,819
Ensembl chr13:83,873,797...83,897,402

G

coagulation factor II, thrombin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [F2 protein results in increased localization of Calcium]

NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor III, tissue factor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in decreased expression of F3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]

PMID:15020266 PMID:15371228 PMID:16009787

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

fatty acid binding protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FABP1 mRNA]

NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of FABP4 mRNA]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

family with sequence similarity 168, member A

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]] which results in increased cleavage of PARP1 protein

NCBI chr 1:155,057,352...155,203,439
Ensembl chr 1:155,057,352...155,201,220

G

Fas cell surface death receptor

multiple interactions
affects response to substance
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the susceptibility to FAS protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FAS mRNA

PMID:16162944 PMID:20665104 PMID:27032576 PMID:31445927

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of FASN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of FASN protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN mRNA]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN protein

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

F-box protein 32

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FBXO32 mRNA

NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436

G

fibroblast growth factor 1

decreases activity
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of FGF1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]

PMID:11742803 PMID:15121739 PMID:15695173 PMID:16325820

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 2

multiple interactions
decreases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FGF2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased expression of and results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]

PMID:11742803 PMID:15631803 PMID:26800359 PMID:29129800

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 7

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SCD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]

PMID:16162944 PMID:19661335

NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929

G

filaggrin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in decreased expression of FLG protein]

NCBI chr 2:178,884,793...178,912,986

G

fibronectin 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of FN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of FN1 protein]

PMID:33270355 PMID:33895847 PMID:39353502

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FOSL1 protein

NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box A1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of FOXA1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]

PMID:25712622 PMID:26363213

NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188

G

forkhead box G1

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FOXG1 protein

NCBI chr 6:72,401,582...72,404,392
Ensembl chr 6:66,666,587...66,678,607

G

forkhead box O1

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in decreased phosphorylation of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased expression of and results in decreased phosphorylation of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and affects the localization of FOXO1 protein

PMID:12438947 PMID:20181797 PMID:25171655 PMID:26385185 PMID:29248466 More...

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

multiple interactions
increases expression
decreases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of FOXO3 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone affects the localization of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol affects the localization of FOXO3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of FOXO3 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of FOXO3 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein]

PMID:16179367 PMID:19168439 PMID:19211844 PMID:19293636 PMID:23099361 More...

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

forkhead box O4

decreases phosphorylation
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO4 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in decreased phosphorylation of FOXO4 protein]

NCBI chr X:70,425,218...70,432,120
Ensembl chr X:66,385,558...66,392,115

G

follicle stimulating hormone subunit beta

multiple interactions
decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein results in decreased activity of FSHB protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370

G

ferritin heavy chain 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of FTH1 mRNA]

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424

G

FYN proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911

G

GA binding protein transcription factor subunit alpha

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]

NCBI chr11:37,375,040...37,404,060
Ensembl chr11:23,888,815...23,917,605

G

guanylate binding protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of GBP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]]

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLC mRNA

PMID:19073151 PMID:20399244 PMID:21469739 PMID:25773745 PMID:25895139 More...

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

decreases expression
multiple interactions
decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLM mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLM mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of GCLM protein

PMID:16972261 PMID:19073151 PMID:25895139 PMID:26577515 PMID:26686574

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

glial cells missing transcription factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in decreased expression of GCM1 protein]

NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:78,925,687...78,938,924

G

growth differentiation factor 11

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of PIK3R1 protein]]

NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725

G

gap junction protein, alpha 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

gap junction protein, beta 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein]

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

galactosidase, beta 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fluorometholone inhibits the reaction [Glucose results in increased activity of GLB1 protein]]

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

GLI family zinc finger 1

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GLI1 protein

NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251

G

GLI family zinc finger 2

multiple interactions

ISO

[HSPA1A protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Formaldehyde] results in increased expression of GLI2 protein

NCBI chr13:32,499,678...32,716,418
Ensembl chr13:29,946,809...30,163,574

G

glycoprotein Ib platelet subunit alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]

NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,352,899...55,356,774

G

G protein-coupled estrogen receptor 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of GPER1 protein]

PMID:22645130 PMID:33035625

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889

G

glutamic--pyruvic transaminase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein]]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions
increases expression

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-iodohexadecanal results in decreased expression of GPX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of GPX1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Potassium Iodide] results in increased expression of GPX1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GPX1 mRNA

PMID:35901927 PMID:38013145

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of and results in decreased activity of GPX4 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Palmitic Acid results in decreased expression of and results in decreased activity of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

granulin precursor

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

gasdermin D

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of GSDMD mRNA]]

PMID:36094782 PMID:36898572

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glycogen synthase kinase 3 alpha

decreases phosphorylation
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3A protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased phosphorylation of GSK3A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3A protein

PMID:14750165 PMID:16179367 PMID:19661225 PMID:21821001

NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

increases activity
decreases phosphorylation
multiple interactions
affects response to substance
decreases response to substance

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in decreased expression of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] which results in decreased susceptibility to Bleomycin; GSK3B mutant form inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein]
GSK3B mRNA affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
GSK3B results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

PMID:14750165 PMID:15753396 PMID:15845746 PMID:15942663 PMID:16179367 More...

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione-disulfide reductase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]

PMID:26577515 PMID:26686574

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA]

NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2]

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase mu 1

increases expression

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GSTM1 mRNA

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase pi 1

increases expression
multiple interactions
decreases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GSTP1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GSTP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GSTP1 mRNA

PMID:22406437 PMID:25271104 PMID:26577515

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

glycophorin A

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]

NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822

G

H2A.X variant histone

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

H3.4 histone, cluster member

multiple interactions

ISO

[Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased acetylation of H3F4 protein

NCBI chr10:43,740,702...43,741,262

G

histidine decarboxylase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]

NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341

G

hypoxia inducible factor 1 subunit alpha

decreases activity
multiple interactions
increases expression
decreases reaction
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of HIF1A protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Deferoxamine results in increased activity of TP53 protein] which results in increased ubiquitination of and results in increased degradation of and results in decreased expression of HIF1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of HIF1A protein
LY294002 inhibits the reaction [estrogen increases expression of Hif1a mRNA] in rat uterus
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HIF1A protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased expression of and results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of HIF1A protein]

CTD
RGD

PMID:11424089 PMID:14726529 PMID:15050414 PMID:15213310 PMID:15631803 More...

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

hexokinase 2

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HK2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HK2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HK2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of HK2 protein]

PMID:34147605 PMID:35122754

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530

G

high mobility group box 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]

PMID:25929181 PMID:27616297

NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

multiple interactions
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2''-galloylhyperin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [kahweol results in increased expression of and results in increased activity of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [pachastrissamine analog results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutacarpine results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutacarpine results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sesquiterpenes analog results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased stability of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[diallyl trisulfide co-treated with Glucose] results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside analog results in increased expression of and results in increased activity of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens results in increased expression of and results in increased activity of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [caffeoylquinic acid analog results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased activity of HMOX1 promoter]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]

PMID:14687664 PMID:15882976 PMID:16109301 PMID:17420286 PMID:18048804 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

HNF1 homeobox A

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HNF1A protein results in increased expression of IL1B mRNA]

NCBI chr12:47,299,171...47,333,457
Ensembl chr12:41,645,587...41,672,104

G

HNF1 homeobox B

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HNF1B mRNA

NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888

G

homeobox A1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of HOXA1]

NCBI chr 4:82,586,505...82,589,209
Ensembl chr 4:81,255,883...81,258,504

G

HRas proto-oncogene, GTPase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of HSPA5 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6KB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]

PMID:18829283 PMID:23877152 PMID:24898257 PMID:30619488

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615

G

heat shock transcription factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form]

PMID:11424089 PMID:21295016

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; [HSPA1A protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Formaldehyde] results in increased expression of GLI2 protein

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]]
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of HSPA5 protein

PMID:19428936 PMID:24898257 PMID:31433112

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family B (small) member 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family B (small) member 8

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HSPB8 protein

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

islet amyloid polypeptide

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]]

NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:175,237,115...175,242,920

G

intercellular adhesion molecule 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of ICAM1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]

PMID:15994321 PMID:25876056 PMID:29329563

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of GBP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of RNF213 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of ICAM1 mRNA]]

PMID:15994321 PMID:16427044 PMID:26278786

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ascorbate-2-phosphate results in increased secretion of IGF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein affects the localization of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; [IGF1 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of GPER1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of ascorbate-2-phosphate results in increased expression of IGF1 mRNA

PMID:12569580 PMID:14745455 PMID:15297429 PMID:15947004 PMID:16465378 More...

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

multiple interactions
decreases response to substance

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to IGF2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]

PMID:23419388 PMID:24055520

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of IGFBP3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]

PMID:12710931 PMID:16682453

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250

G

interleukin 17A

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

increases expression
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of IL18 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased secretion of IL18 protein]]
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased expression of IL18 protein

PMID:30726812 PMID:36094782

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1A protein results in increased expression of BDKRB1 protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL1B protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of IL1B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HNF1A protein results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [OCLN protein results in increased phosphorylation of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased secretion of IL1B protein]]

PMID:15350541 PMID:16359550 PMID:19446813 PMID:25171655 PMID:25929181 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL4 protein]

PMID:10611455 PMID:16179367 PMID:25929181

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL6 protein results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of and results in increased secretion of IL6 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]

PMID:20600219 PMID:21131394 PMID:21474332 PMID:24530660 PMID:24631921 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Anthraquinones co-treated with INS1 protein] affects the localization of SLC2A4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased uptake of Glucose]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR122 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR132 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR212 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]

PMID:11306697 PMID:17962351 PMID:19052259 PMID:23920219 PMID:25543134 More...

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [triphenyl phosphate promotes the reaction [INS protein results in increased import of Glucose]]

PMID:17550345 PMID:18359480 PMID:25982963 PMID:26364587 PMID:28163246

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

inositol hexakisphosphate kinase 1

decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of IP6K1 protein

NCBI chr 8:108,693,068...108,737,278

G

insulin receptor substrate 1

decreases phosphorylation
multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein
Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein]

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122

G

insulin receptor substrate 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]]

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482

G

integrin subunit alpha 5

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]

NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837

G

integrin subunit alpha M

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]

PMID:11980903 PMID:16617325 PMID:19176369 PMID:26254549

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit alpha V

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639

G

integrin subunit beta 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]

PMID:15213856 PMID:16465378

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679

G

Janus kinase 2

multiple interactions

ISO

LY294002 inhibits the reaction [cisplatin increases phosphorylation of Jak2 protein in kidney]

RGD

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of JUN protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of JUN protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased phosphorylation of JUN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased phosphorylation of JUN protein

PMID:14687664 PMID:15850772 PMID:16018989 PMID:18495116 PMID:20338993 More...

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

KIT proto-oncogene receptor tyrosine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein]

NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652

G

KIT ligand

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 15

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine results in increased expression of KLF15 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine results in increased expression of KLF15 protein]

NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:122,965,807...122,978,374

G

KLF transcription factor 4

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of KLF4 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]

PMID:21484412 PMID:22685291

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

kallikrein 1-related peptidase C10

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052

G

lactate dehydrogenase A

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of LDHA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LDHA protein

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472

G

lymphoid enhancer binding factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [loliolide results in increased expression of LEF1 mRNA]

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794

G

leptin

decreases expression
multiple interactions
decreases secretion

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein

PMID:19254925 PMID:21351249 PMID:28571770 PMID:29248466

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in decreased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908

G

galectin 3

multiple interactions
decreases response to substance

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of and affects the localization of LGALS3 protein; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; Cycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; Dactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein]
LGALS3 results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025

G

luteinizing hormone subunit beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521

G

lipase A, lysosomal acid type

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIPA mRNA]

NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633

G

lipoprotein lipase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of ICAM1 mRNA]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of LPL mRNA]

PMID:15659569 PMID:15994321

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249

G

mannose-6-phosphate receptor, cation dependent

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of M6PR mRNA]

NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216

G

MALT1 paracaspase

decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MALT1 protein

NCBI chr18:61,212,290...61,266,272
Ensembl chr18:58,942,299...58,994,260

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases lipidation
increases cleavage

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [saikosaponin D results in decreased cleavage of MAP1LC3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [saikosaponin D results in increased expression of MAP1LC3B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of MAP1LC3B protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of MAP1LC3B protein]
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with pachastrissamine analog] results in increased lipidation of MAP1LC3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased lipidation of MAP1LC3B protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of MAP1LC3B protein

PMID:30611790 PMID:35123989 PMID:38729284

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

microtubule-associated protein 2

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MAP2 protein

NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO
EXP

MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]

PMID:12411397 PMID:15850772

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase kinase 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of MAP2K3 mRNA]

NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492

G

mitogen-activated protein kinase kinase kinase 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]

NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:43,350,098...43,414,463

G

mitogen activated protein kinase 1

increases phosphorylation
decreases phosphorylation
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MAPK1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [epigallocatechin gallate results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ON123300 results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in decreased phosphorylation of MAPK1 protein; tamibarotene promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Antigen-Antibody Complex results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPK1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK1 protein

PMID:12834810 PMID:14757120 PMID:15020266 PMID:15072920 PMID:15177934 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased phosphorylation of MAPK10 protein]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions
decreases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [epigallocatechin gallate results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ON123300 results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in decreased phosphorylation of MAPK3 protein; tamibarotene promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MAPK3 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Antigen-Antibody Complex results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPK3 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK3 protein

PMID:12834810 PMID:14757120 PMID:15020266 PMID:15072920 PMID:15177934 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased phosphorylation of MAPK8 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased phosphorylation of MAPK8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of MAPK8 protein

PMID:11306679 PMID:16018989 PMID:21420390 PMID:26385185 PMID:33771252 More...

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of MAPK9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased phosphorylation of MAPK9 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of MAPK9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK9 protein]

PMID:14688022 PMID:16018989 PMID:26385185 PMID:34160118

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]]

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression
affects expression
increases degradation

ISO

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of MCL1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 protein; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MCL1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the expression of MCL1 mRNA

PMID:17148679 PMID:20856197 PMID:21821001 PMID:22046442 PMID:23353698

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

microRNA 122

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR122 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA]

PMID:23920219 PMID:29248466

NCBI chr18:58,758,703...58,758,787

G

microRNA 132

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR132 mRNA]

NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,023,696...60,023,796

G

microRNA 141

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]]

NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332

G

microRNA 146a

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA]

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 21

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MIR21 mRNA results in decreased susceptibility to Cisplatin]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MIR21 mRNA

PMID:23272133 PMID:23466500

NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348

G

microRNA 212

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR212 mRNA]

NCBI chr10:60,521,740...60,521,850
Ensembl chr10:60,023,403...60,023,513

G

melanocyte inducing transcription factor

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sweroside results in increased expression of MITF protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MITF protein

PMID:21816215 PMID:26051519

NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145

G

marker of proliferation Ki-67

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of MKI67 protein]

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

matrix metallopeptidase 1

multiple interactions
decreases expression
decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of MMP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP1 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP1 protein

PMID:19393235 PMID:19561517 PMID:21245013 PMID:22326785 PMID:32613688

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 10

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP10 protein

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 12

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]

PMID:16359550 PMID:16571779

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]

PMID:16571779 PMID:20338993

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

decreases expression
decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP14 protein

PMID:19393235 PMID:22326785

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

multiple interactions
decreases expression
decreases activity

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP2 protein

PMID:18805481 PMID:19393235 PMID:19956873 PMID:22326785 PMID:23566884 More...

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
decreases expression
decreases activity

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP9 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP9 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butein results in decreased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in decreased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in increased expression of and results in increased activity of MMP9 protein]; [kahweol acetate co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]

PMID:17560598 PMID:18424783 PMID:19299917 PMID:19393235 PMID:19401153 More...

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

methylsterol monooxygenase 1

decreases response to substance

ISO

MSMO1 protein results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of COX1 protein]

NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

metallothionein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT1A mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]

PMID:11551972 PMID:17363595

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT2A mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]

PMID:17363595 PMID:24680926

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 3

multiple interactions
decreases response to substance

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Doxorubicin]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to MT3 protein

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Lipopolysaccharides results in decreased expression of MTOR mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Estradiol] results in decreased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Lipopolysaccharides results in increased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MTOR protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MTOR protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]

PMID:17148679 PMID:17623046 PMID:19139269 PMID:23793038 PMID:26282490 More...

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]

PMID:21544845 PMID:34167450

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of MYC protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MYC protein

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

MYCN proto-oncogene, bHLH transcription factor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]

NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590

G

myosin heavy chain 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]

NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295

G

Nanog homeobox

multiple interactions
decreases expression

ISO

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of NANOG protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NANOG protein

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116

G

NSF attachment protein alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NAPA mRNA]

NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869

G

NADH:ubiquinone oxidoreductase subunit B8

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NDUFB8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of NDUFB8 protein]

NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817

G

nestin

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NES protein

NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777

G

NFE2 like bZIP transcription factor 2

decreases activity
decreases expression
multiple interactions
increases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NFE2L2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2''-galloylhyperin affects the localization of and results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of and affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of NFE2L2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Docosahexaenoic Acids affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [gypenoside analog affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [SMARCA4A protein affects the reaction [Glucose affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [caffeoylquinic acid analog results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased expression of and affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased expression of and affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triterpenes analog affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Palmitic Acid results in decreased expression of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of NFE2L2 protein

PMID:17640564 PMID:18815141 PMID:19073151 PMID:19647727 PMID:19781563 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [NFKB1 protein binds to NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [REL protein binds to NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [RELA protein binds to NFKB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased activity of NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]

PMID:16256798 PMID:18006147 PMID:18207479 PMID:19446813 PMID:21173233 More...

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of NFKBIA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased phosphorylation of NFKBIA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELA protein binds to NFKBIA promoter]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein]

PMID:17172471 PMID:21173233 PMID:24085292 PMID:25271104 PMID:25656647 More...

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [oenothein B results in decreased phosphorylation of NFKBIB protein]

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862

G

nerve growth factor

multiple interactions
decreases activity

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased expression of NGF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased expression of NGF protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of NGF protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased localization of TRPV1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein]

PMID:12834810 PMID:16319926 PMID:17324588 PMID:21975456

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452

G

NLR family, CARD domain containing 5

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased secretion of VEGFA protein]

NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121

G

NLR family, pyrin domain containing 3

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of NLRP3 protein]]

PMID:36094782 PMID:36898572

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

decreases activity
multiple interactions
increases expression
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of NOS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of NOS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NOS2 mRNA

PMID:10527657 PMID:16417967 PMID:17570326 PMID:23500011 PMID:23735482 More...

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amurensin G results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anagliptin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased expression of NOS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS3 protein]

PMID:11788791 PMID:12821261 PMID:19356108 PMID:19446813 PMID:19616084 More...

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]

PMID:17513037 PMID:25118938

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

NADPH oxidase 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236

G

NADPH oxidase 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

natriuretic peptide A

increases expression
multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of NPPA mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of NQO1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NQO1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NQO1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein promotes the reaction [Glucose results in increased expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NQO1 protein]

PMID:15896333 PMID:17360324 PMID:26686574 PMID:29353218 PMID:33270355 More...

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NR4A3 mRNA]

NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733

G

nuclear respiratory factor 1

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NRF1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of NRF1 mRNA]

PMID:17179207 PMID:24041027

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

neuregulin 1

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP10 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA]

PMID:19801490 PMID:23071612

NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884

G

NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL

decreases response to substance

ISO

NSDHL protein results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142

G

neurotrophin 3

decreases transport

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased transport of NTF3 protein

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophin 4

decreases transport

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased transport of NTF4 protein

NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:95,893,457...95,897,243

G

neurotrophic receptor tyrosine kinase 1

multiple interactions
increases phosphorylation

ISO

intybin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of NTRK1 protein]

NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770

G

neurotensin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

nucleoporin 153

affects localization
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of NUP153 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]

NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876

G

nucleoporin 88

affects localization
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of NUP88 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]

NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257

G

occludin

multiple interactions
affects localization

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [OCLN protein results in increased phosphorylation of IL1B protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of OCLN protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of OCLN protein]

PMID:15350541 PMID:19297429 PMID:24200059

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150

G

oxidative stress induced growth inhibitor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Docosahexaenoic Acids results in increased expression of OSGIN1 protein]

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

Parkinsonism associated deglycase

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]

NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [pachastrissamine analog results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of PARP1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]] which results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of PARP1 protein; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of PARP1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]

PMID:14687664 PMID:14688022 PMID:16412023 PMID:19261616 PMID:20386985 More...

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

pro-apoptotic WT1 regulator

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PAWR mutant form results in decreased susceptibility to Cisplatin]

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

proliferating cell nuclear antigen

multiple interactions
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with kaempferol] inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]
LY294002 inhibits the reaction [hypoxia increases expression of PCNA mRNA in rat pulmonary artery smooth muscle cells]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of PCNA protein]

CTD
RGD

PMID:24898257 PMID:34896440 PMID:36940862 PMID:26485208

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

programmed cell death 4

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tretinoin results in increased expression of PDCD4 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PDCD4 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PDCD4 protein

PMID:17259349 PMID:23272133

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275

G

platelet derived growth factor subunit B

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]; U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]

PMID:15919668 PMID:23457620 PMID:23958495

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984

G

pyruvate dehydrogenase kinase 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038

G

pancreatic and duodenal homeobox 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of PDX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

prohibitin 1

multiple interactions
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein results in decreased activity of FSHB protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

decreases activity
increases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PIK3CA mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PIK3CA mRNA]

PMID:16179367 PMID:23793038 PMID:31522336

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

decreases activity
multiple interactions
decreases expression
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CB protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of PIK3CB protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog results in decreased expression of PIK3CB protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of PIK3CB protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of PIK3CB protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PIK3CB mRNA

PMID:16179367 PMID:31522336 PMID:35122754 PMID:38729284

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases activity
multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CD protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3CD mRNA

PMID:16179367 PMID:31522336

NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

multiple interactions
decreases expression
decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of and results in increased activity of PIK3CG protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of PIK3CG mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3CG mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CG protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CG mRNA]

PMID:15020266 PMID:15178407 PMID:16179367 PMID:16794257 PMID:31522336

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of PIK3R1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of PIK3R1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of PIK3R1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of PIK3R1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased phosphorylation of PIK3R1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3R1 protein modified form

PMID:30911355 PMID:32044604 PMID:33895847 PMID:35568058 PMID:37934488 More...

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631

G

Pim-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of PIM1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of PIM1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of PIM1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of PIM1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of PIM1 mRNA]; [Resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of PIM1 protein

NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,554,921...7,559,174

G

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIN1 protein

NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785

G

pyruvate kinase M1/2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of PKM mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of PKM protein]

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599

G

plasminogen activator, urokinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [hispolon results in decreased expression of and results in decreased activity of PLAU protein]

NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in increased expression of PMAIP1 protein

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429

G

periostin

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of POSTN mRNA]

PMID:15121739 PMID:16325820

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

POU class 5 homeobox 1

multiple interactions
decreases expression

ISO

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of POU5F1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of POU5F1 protein

NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPARG mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PPARGC1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of PPARGC1A mRNA]

PMID:17179207 PMID:24041027 PMID:30194976

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656

G

peptidylprolyl isomerase D

multiple interactions
increases expression

EXP

Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPID protein]

NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:164,727,779...164,740,221

G

peptidylprolyl isomerase F

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPIF mRNA]

NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775

G

protein phosphatase 2, regulatory subunit B, beta

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPP2R2B mRNA]

NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,653,721...35,081,025

G

protein kinase C, delta

multiple interactions
decreases phosphorylation
affects localization

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]; sodium arsenite promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of PRKCD protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of PRKCD protein

PMID:11424089 PMID:17171638 PMID:20082316

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, zeta

decreases phosphorylation
affects localization

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of PRKCZ protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of PRKCZ protein

PMID:12970779 PMID:15735031

NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367

G

phosphatase and tensin homolog

multiple interactions
affects response to substance
increases expression

ISO
EXP

[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA; PTEN protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]
PTEN protein affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PTEN mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of PTEN mRNA]

PMID:18622747 PMID:19808899 PMID:32370496 PMID:33256086

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PTGS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PTGS2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased expression of PTGS2]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]

PMID:14687664 PMID:15980035 PMID:17084486 PMID:17093206 PMID:18840457 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]

PMID:16168102 PMID:26109002

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PTPN1 mRNA]

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504

G

protein tyrosine phosphatase, non-receptor type 11

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]

NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 5

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]

NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882

G

PYD and CARD domain containing

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of PYCARD protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of PYCARD protein]]

PMID:36094782 PMID:36898572

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955

G

RAB32, member RAS oncogene family

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of RAB32 mRNA]

NCBI chr 1:4,946,193...4,961,003
Ensembl chr 1:4,945,036...4,960,934

G

RAD23 homolog B, nucleotide excision repair protein

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]

NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased localization of RAF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased localization of RAF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of RAF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ON123300 results in increased phosphorylation of RAF1 protein]

PMID:12834810 PMID:16763222 PMID:24568969

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317

G

RAP1A, member of RAS oncogene family

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501

G

RB transcriptional corepressor 1

multiple interactions
decreases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RB1 protein
[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]

PMID:14971663 PMID:15601625 PMID:15778701 PMID:18353414

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RB transcriptional corepressor like 1

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of RBL1 protein

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

REL proto-oncogene, NF-kB subunit

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [REL protein binds to NFKB1 protein]

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression
affects localization

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased activity of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of RELA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of RELA protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide affects the localization of RELA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of RELA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol affects the localization of and results in increased activity of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELA protein binds to NFKBIA promoter]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in decreased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [oenothein B results in decreased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [RELA protein binds to NFKB1 protein]

PMID:16256798 PMID:17982072 PMID:18006147 PMID:18207479 PMID:18295389 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

reelin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]

NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211

G

ras homolog family member A

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased activity of RHOA protein]

NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746

G

ring finger protein 213

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of RNF213 mRNA]

NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butylparaben results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6 protein

PMID:12939469 PMID:14502240 PMID:15297429 PMID:15778701 PMID:16412023 More...

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase A1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein]

NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272

G

ribosomal protein S6 kinase B1

decreases phosphorylation
decreases expression
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6KB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of RPS6KB1 protein modified form
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6KB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of RPS6KB1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butylparaben results in decreased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [quinocetone results in decreased phosphorylation of RPS6KB1 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RPS6KB1 protein; U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]

PMID:12411397 PMID:14516795 PMID:14769825 PMID:15297429 PMID:15919668 More...

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

ribonucleotide reductase regulatory subunit M2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]

NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773

G

RUNX family transcription factor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167

G

scavenger receptor class B, member 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SCARB2 mRNA]

NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813

G

stearoyl-CoA desaturase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SCD protein]

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

Sec23 homolog A, COPII coat complex component

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SEC23A mRNA]

NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035

G

surfactant protein C

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SFTPC protein

NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777

G

signal-regulatory protein alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]

NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:116,819,726...116,858,098

G

sirtuin 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of SIRT1 mRNA]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260

G

sirtuin 6

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein]

NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914

G

solute carrier family 1 member 1

multiple interactions
decreases activity

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of SLC1A1 protein

PMID:16150575 PMID:23602688 PMID:24355585

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 1 member 2

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]

PMID:22645130 PMID:24782323

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 27 member 5

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SLC27A5 mRNA]

NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172

G

solute carrier family 2 member 1

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of SLC2A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of SLC2A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased localization of SLC2A1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SLC2A1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of SLC2A1 protein]; PTEN protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 protein]]

PMID:15956784 PMID:19808899 PMID:34147605 PMID:35122754

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 2 member 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Anthraquinones co-treated with INS1 protein] affects the localization of SLC2A4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Anthraquinones affects the localization of SLC2A4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]

PMID:31071387 PMID:36325883

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 2 member 5

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 5 member 5

multiple interactions
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of SLC5A5 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-iodohexadecanal results in decreased expression of SLC5A5 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Potassium Iodide results in decreased expression of SLC5A5 mRNA]

PMID:20300827 PMID:25644787 PMID:38013145

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697

G

solute carrier family 6 member 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased expression of SLC6A3 protein]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 7 member 11

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of SLC7A11 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Palmitic Acid results in decreased expression of SLC7A11 protein]

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 8 member A3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased expression of SLC8A3 protein]

NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508

G

SMAD family member 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of SMAD2 protein]

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

snail family transcriptional repressor 1

decreases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SNAI1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]

PMID:23921149 PMID:24122885 PMID:25118938 PMID:25656647 PMID:30609689 More...

NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 protein]

PMID:30609689 PMID:33396024

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200

G

suppressor of cytokine signaling 3

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]

PMID:22685291 PMID:25712622

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein]]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases expression
multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of SOD2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of SOD2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in decreased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of SOD2 protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]

PMID:15308628 PMID:16256798 PMID:20542495 PMID:20596034 PMID:23159718 More...

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

SRY-box transcription factor 2

decreases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SOX2 protein
[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of SOX2 protein

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338

G

Sp1 transcription factor

multiple interactions
increases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of SP1 protein

PMID:17307335 PMID:21351249 PMID:26385185

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

secreted phosphoprotein 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased expression of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [pachastrissamine analog results in increased expression of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 affects the localization of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate affects the localization of SQSTM1 protein]]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SQSTM1 protein]

PMID:17360324 PMID:33689844 PMID:35123989 PMID:36343798 PMID:38729284

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SRC protein]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of SREBF1 protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SREBF1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]

PMID:16162944 PMID:22031849 PMID:25398788 PMID:30205135

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

serine racemase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]

NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein]
Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of STAT3 protein]

PMID:16427044 PMID:29894800 PMID:34455488

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

stathmin 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [arsenic trioxide results in increased degradation of STMN1 protein]

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154

G

steroid sulfatase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]

PMID:16178010 PMID:24055520

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

syntaxin 7

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of STX7 mRNA]

NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279

G

synaptophysin

multiple interactions
increases expression

ISO

intybin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of SYP protein]

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745

G

telomerase reverse transcriptase

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of TERT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]

PMID:15590986 PMID:16798746 PMID:30851366

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

G

transferrin

decreases activity

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of TF protein

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511

G

transcription factor A, mitochondrial

multiple interactions

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TFAM mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of TFAM mRNA]

PMID:17179207 PMID:24041027 PMID:30194976

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292

G

transferrin receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor alpha

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]

NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

decreases response to substance
increases expression
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to TGFB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TGFB1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CG mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]

PMID:16325820 PMID:17082237 PMID:21131394 PMID:24727557 PMID:26054450 More...

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

TGFB-induced factor homeobox 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]

PMID:21649584 PMID:25791921

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

G

transglutaminase 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

tyrosine hydroxylase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [HU 211 results in decreased expression of TH mRNA]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767

G

thrombomodulin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of THBD mRNA]

NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193

G

thrombopoietin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]

Ensembl chr11:80,182,820...80,188,167

G

TIMP metallopeptidase inhibitor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

G

tight junction protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]

PMID:24200059 PMID:30609689

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 4

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
increases response to substance

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of TNF protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased susceptibility to TNF protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of MMP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Nitric Oxide]]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cysteine analog results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Silicon Dioxide results in increased expression of TNF protein]

PMID:12805067 PMID:14502240 PMID:16794257 PMID:17172471 PMID:17464197 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of TNFAIP3 protein

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 10b

increases expression
multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein
resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein]

PMID:15942663 PMID:21179458

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

TNF superfamily member 10

multiple interactions
increases expression

ISO

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with TNFSF10 protein] results in increased activity of BAX protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of PARP1 protein; resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFSF10 protein]

PMID:19261616 PMID:20097879 PMID:21179458

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 11

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

multiple interactions
increases phosphorylation
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fluorometholone inhibits the reaction [Glucose results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in decreased expression of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of TP53 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with cyadox] results in increased expression of TP53 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Hydrogen Peroxide] results in increased expression of TP53 mRNA; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein]; TP53 protein results in increased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Deferoxamine results in increased activity of TP53 protein] which results in increased ubiquitination of and results in increased degradation of and results in decreased expression of HIF1A protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of TP53 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TP53 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TP53 protein

PMID:15001399 PMID:15763944 PMID:16024610 PMID:17534123 PMID:19950214 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tripartite motif containing 63

decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of TRIM63 mRNA

NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased localization of TRPV1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513

G

titin

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]

NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741

G

twist family bHLH transcription factor 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]]

NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653

G

thioredoxin 1

multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TXN protein results in decreased susceptibility to Oxygen]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of TXN1 protein]

PMID:20812253 PMID:28082123

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-iodohexadecanal results in decreased expression of TXNRD1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Potassium Iodide results in decreased expression of TXNRD1 mRNA]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYR protein]; [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR protein
[Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein

PMID:21816215 PMID:28849034

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

tyrosinase-related protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYRP1 protein]

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516

G

uncoupling protein 1

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of UGT1A1 mRNA]

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of UQCRC1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of UQCRC1 protein]

NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:109,589,706...109,601,480

G

vascular cell adhesion molecule 1

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958

G

vitamin D receptor

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]]

NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

decreases expression
decreases reaction
decreases secretion
multiple interactions

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of VEGFA mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of VEGFA protein
LY294002 inhibits the reaction [estrogen increases expression of Vegfa mRNA] in rat uterus
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of VEGFA protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cornin iridoid results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]

CTD
RGD

PMID:15040022 PMID:15050414 PMID:15308628 PMID:15930297 PMID:16638750 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vascular endothelial growth factor C

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [VEGFC protein results in increased phosphorylation of AKT1 protein]

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848

G

vimentin

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

PMID:25656647 PMID:27856280 PMID:30609689 PMID:33396024

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

Wnt family member 5A

multiple interactions

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [loliolide results in increased expression of WNT5A mRNA]

NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234

G

X-linked inhibitor of apoptosis

multiple interactions
decreases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of XIAP protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of XIAP protein

PMID:15339911 PMID:18071906 PMID:20856197

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

X-ray repair cross complementing 1

multiple interactions
decreases stability

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased stability of XRCC1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased stability of XRCC1 protein

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

G

zinc finger CCCH type containing 12A

multiple interactions

EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of ZC3H12A protein]

NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:137,376,564...137,385,351

N-acetyl-beta-D-glucosamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiopoietin-like 4

increases expression
decreases expression

ISO

Acetylglucosamine results in increased expression of ANGPTL4 mRNA
Acetylglucosamine results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

ISO

Acetylglucosamine results in decreased expression of AP1S3 mRNA

NCBI chr 9:88,399,109...88,458,396
Ensembl chr 9:80,950,715...81,009,798

G

amyloid beta precursor protein

multiple interactions

ISO

[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

Rho GDP dissociation inhibitor beta

decreases expression

ISO

Acetylglucosamine results in decreased expression of ARHGDIB mRNA

NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:169,822,952...169,841,658

G

actin related protein 2/3 complex, subunit 4

decreases expression

ISO

Acetylglucosamine results in decreased expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:146,522,176...146,532,785

G

calmodulin-like 5

increases expression

ISO

Acetylglucosamine results in increased expression of CALML5 mRNA

NCBI chr17:71,304,326...71,305,245

G

catalase

increases expression

ISO

Acetylglucosamine results in increased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

chaperonin containing TCP1 subunit 5

decreases expression

ISO

Acetylglucosamine results in decreased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

cyclin dependent kinase like 1

decreases expression

ISO

Acetylglucosamine results in decreased expression of CDKL1 mRNA

NCBI chr 6:88,224,154...88,273,434
Ensembl chr 6:88,224,143...88,270,276

G

carboxylesterase 1D

increases expression

ISO

Acetylglucosamine results in increased expression of CES1 mRNA

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035

G

dopachrome tautomerase

increases expression

ISO

Acetylglucosamine results in increased expression of DCT mRNA

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836

G

diaphanous-related formin 2

decreases expression

ISO

Acetylglucosamine results in decreased expression of DIAPH2 mRNA

NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869

G

enolase 2

increases expression

ISO

Acetylglucosamine results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980

G

F-box protein 10

increases expression

ISO

Acetylglucosamine results in increased expression of FBXO10 mRNA

NCBI chr 5:64,092,709...64,139,054
Ensembl chr 5:59,297,045...59,343,348

G

F-box protein 4

increases expression

ISO

Acetylglucosamine results in increased expression of FBXO4 mRNA

NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792

G

ficolin B

affects binding

ISO

FCN1 protein binds to Acetylglucosamine

NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151

G

glutathione peroxidase 1

increases expression

ISO

Acetylglucosamine results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione S-transferase alpha 4

increases expression

ISO

Acetylglucosamine results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase theta 2

increases expression

ISO

Acetylglucosamine results in increased expression of GSTT2 mRNA

NCBI chr20:12,819,053...12,822,724
Ensembl chr20:12,819,170...12,823,288

G

hexokinase 2

increases expression

ISO

Acetylglucosamine results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530

G

intercellular adhesion molecule 1

multiple interactions

ISO

Acetylglucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

increases expression
increases secretion

ISO

Acetylglucosamine analog results in increased expression of IFNG mRNA
Acetylglucosamine analog results in increased secretion of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 4

increases expression

ISO

Acetylglucosamine analog results in increased expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

killer cell lectin like receptor B1A

affects binding

EXP

Acetylglucosamine analog binds to KLRB1A protein

NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675

G

ornithine decarboxylase 1

decreases expression

ISO

Acetylglucosamine results in decreased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression

ISO

Acetylglucosamine results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

paraoxonase 2

increases expression

ISO

Acetylglucosamine results in increased expression of PON2 mRNA

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

[Acetylglucosamine co-treated with Glucose] binds to PPARA protein; Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

protein phosphatase 1, regulatory subunit 9A

decreases expression

ISO

Acetylglucosamine results in decreased expression of PPP1R9A mRNA

NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907

G

peroxiredoxin 3

increases expression

ISO

Acetylglucosamine results in increased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

peroxiredoxin 5

increases expression

ISO

Acetylglucosamine results in increased expression of PRDX5 mRNA

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:204,099,826...204,114,268

G

presenilin 1

multiple interactions

ISO

[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine]

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650

G

retinol binding protein 1

decreases expression
increases expression

ISO

Acetylglucosamine results in decreased expression of RBP1 mRNA
Acetylglucosamine results in increased expression of RBP1 mRNA

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

selectin E

affects binding

ISO

[Acetylglucosamine analog binds to Biotin] which binds to SELE protein; Acetylglucosamine analog binds to SELE protein

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741

G

selectin L

affects binding

EXP

[Acetylglucosamine analog binds to Biotin] which binds to SELL protein; Acetylglucosamine analog binds to SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

selectin P

affects binding

ISO

[Acetylglucosamine analog binds to Biotin] which binds to SELP protein; Acetylglucosamine analog binds to SELP protein

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845

G

serpin family A member 3N

decreases expression

ISO

Acetylglucosamine results in decreased expression of SERPINA3 mRNA

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 3A

increases expression

ISO

Acetylglucosamine results in increased expression of SERPINB4 mRNA

NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985

G

solute carrier family 2 member 3

decreases expression
increases expression

ISO

Acetylglucosamine results in decreased expression of SLC2A3 mRNA
Acetylglucosamine results in increased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 7 member 5

decreases expression

ISO

Acetylglucosamine results in decreased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823

G

sorting nexin 5

decreases expression

ISO

Acetylglucosamine results in decreased expression of SNX5 mRNA

NCBI chr 3:152,075,258...152,094,508
Ensembl chr 3:131,621,880...131,641,192

G

superoxide dismutase 2

decreases expression

ISO

Acetylglucosamine results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

transglutaminase 5

increases expression

ISO

Acetylglucosamine results in increased expression of TGM5 mRNA

NCBI chr 3:108,008,087...108,044,013
Ensembl chr 3:108,008,143...108,043,976

G

tumor necrosis factor

multiple interactions

ISO

Acetylglucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tubulin tyrosine ligase like 3

decreases expression

ISO

Acetylglucosamine results in decreased expression of TTLL3 mRNA

NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889

G

tubulin, beta 5 class I

decreases expression

ISO

Acetylglucosamine results in decreased expression of TUBB mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

tubulin gamma complex component 3

decreases expression

ISO

Acetylglucosamine results in decreased expression of TUBGCP3 mRNA

NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499

G

ubiquitin-conjugating enzyme E2D 3

increases expression

ISO

Acetylglucosamine results in increased expression of UBE2D3 mRNA

NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081

N-acetyl-D-glucosamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiopoietin-like 4

increases expression
decreases expression

ISO

Acetylglucosamine results in increased expression of ANGPTL4 mRNA
Acetylglucosamine results in decreased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

ISO

Acetylglucosamine results in decreased expression of AP1S3 mRNA

NCBI chr 9:88,399,109...88,458,396
Ensembl chr 9:80,950,715...81,009,798

G

amyloid beta precursor protein

multiple interactions

ISO

[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

Rho GDP dissociation inhibitor beta

decreases expression

ISO

Acetylglucosamine results in decreased expression of ARHGDIB mRNA

NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:169,822,952...169,841,658

G

actin related protein 2/3 complex, subunit 4

decreases expression

ISO

Acetylglucosamine results in decreased expression of ARPC4 mRNA

NCBI chr 4:148,077,799...148,088,427
Ensembl chr 4:146,522,176...146,532,785

G

calmodulin-like 5

increases expression

ISO

Acetylglucosamine results in increased expression of CALML5 mRNA

NCBI chr17:71,304,326...71,305,245

G

catalase

increases expression

ISO

Acetylglucosamine results in increased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

chaperonin containing TCP1 subunit 5

decreases expression

ISO

Acetylglucosamine results in decreased expression of CCT5 mRNA

NCBI chr 2:82,591,750...82,602,903
Ensembl chr 2:82,590,630...82,602,930

G

cyclin dependent kinase like 1

decreases expression

ISO

Acetylglucosamine results in decreased expression of CDKL1 mRNA

NCBI chr 6:88,224,154...88,273,434
Ensembl chr 6:88,224,143...88,270,276

G

carboxylesterase 1D

increases expression

ISO

Acetylglucosamine results in increased expression of CES1 mRNA

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035

G

dopachrome tautomerase

increases expression

ISO

Acetylglucosamine results in increased expression of DCT mRNA

NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836

G

diaphanous-related formin 2

decreases expression

ISO

Acetylglucosamine results in decreased expression of DIAPH2 mRNA

NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869

G

enolase 2

increases expression

ISO

Acetylglucosamine results in increased expression of ENO2 mRNA

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980

G

F-box protein 10

increases expression

ISO

Acetylglucosamine results in increased expression of FBXO10 mRNA

NCBI chr 5:64,092,709...64,139,054
Ensembl chr 5:59,297,045...59,343,348

G

F-box protein 4

increases expression

ISO

Acetylglucosamine results in increased expression of FBXO4 mRNA

NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792

G

ficolin B

affects binding

ISO

FCN1 protein binds to Acetylglucosamine

NCBI chr 3:11,393,713...11,402,198
Ensembl chr 3:11,393,739...11,402,151

G

glutathione peroxidase 1

increases expression

ISO

Acetylglucosamine results in increased expression of GPX1 mRNA

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione S-transferase alpha 4

increases expression

ISO

Acetylglucosamine results in increased expression of GSTA4 mRNA

NCBI chr 8:87,947,247...87,964,490
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase theta 2

increases expression

ISO

Acetylglucosamine results in increased expression of GSTT2 mRNA

NCBI chr20:12,819,053...12,822,724
Ensembl chr20:12,819,170...12,823,288

G

hexokinase 2

increases expression

ISO

Acetylglucosamine results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530

G

intercellular adhesion molecule 1

multiple interactions

ISO

Acetylglucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

increases expression
increases secretion

ISO

Acetylglucosamine analog results in increased expression of IFNG mRNA
Acetylglucosamine analog results in increased secretion of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 4

increases expression

ISO

Acetylglucosamine analog results in increased expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

killer cell lectin like receptor B1A

affects binding

EXP

Acetylglucosamine analog binds to KLRB1A protein

NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675

G

ornithine decarboxylase 1

decreases expression

ISO

Acetylglucosamine results in decreased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression

ISO

Acetylglucosamine results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

paraoxonase 2

increases expression

ISO

Acetylglucosamine results in increased expression of PON2 mRNA

NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

[Acetylglucosamine co-treated with Glucose] binds to PPARA protein; Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

protein phosphatase 1, regulatory subunit 9A

decreases expression

ISO

Acetylglucosamine results in decreased expression of PPP1R9A mRNA

NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907

G

peroxiredoxin 3

increases expression

ISO

Acetylglucosamine results in increased expression of PRDX3 mRNA

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

peroxiredoxin 5

increases expression

ISO

Acetylglucosamine results in increased expression of PRDX5 mRNA

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:204,099,826...204,114,268

G

presenilin 1

multiple interactions

ISO

[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of Acetylglucosamine]

NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:103,323,120...103,371,650

G

retinol binding protein 1

decreases expression
increases expression

ISO

Acetylglucosamine results in decreased expression of RBP1 mRNA
Acetylglucosamine results in increased expression of RBP1 mRNA

NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743

G

selectin E

affects binding

ISO

[Acetylglucosamine analog binds to Biotin] which binds to SELE protein; Acetylglucosamine analog binds to SELE protein

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741

G

selectin L

affects binding

EXP

[Acetylglucosamine analog binds to Biotin] which binds to SELL protein; Acetylglucosamine analog binds to SELL protein

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

selectin P

affects binding

ISO

[Acetylglucosamine analog binds to Biotin] which binds to SELP protein; Acetylglucosamine analog binds to SELP protein

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845

G

serpin family A member 3N

decreases expression

ISO

Acetylglucosamine results in decreased expression of SERPINA3 mRNA

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 3A

increases expression

ISO

Acetylglucosamine results in increased expression of SERPINB4 mRNA

NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985

G

solute carrier family 2 member 3

increases expression
decreases expression

ISO

Acetylglucosamine results in increased expression of SLC2A3 mRNA
Acetylglucosamine results in decreased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 7 member 5

decreases expression

ISO

Acetylglucosamine results in decreased expression of SLC7A5 mRNA

NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823

G

sorting nexin 5

decreases expression

ISO

Acetylglucosamine results in decreased expression of SNX5 mRNA

NCBI chr 3:152,075,258...152,094,508
Ensembl chr 3:131,621,880...131,641,192

G

superoxide dismutase 2

decreases expression

ISO

Acetylglucosamine results in decreased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

transglutaminase 5

increases expression

ISO

Acetylglucosamine results in increased expression of TGM5 mRNA

NCBI chr 3:108,008,087...108,044,013
Ensembl chr 3:108,008,143...108,043,976

G

tumor necrosis factor

multiple interactions

ISO

Acetylglucosamine inhibits the reaction [TNF results in increased expression of ICAM1 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tubulin tyrosine ligase like 3

decreases expression

ISO

Acetylglucosamine results in decreased expression of TTLL3 mRNA

NCBI chr 4:148,088,575...148,113,526
Ensembl chr 4:146,533,953...146,557,889

G

tubulin, beta 5 class I

decreases expression

ISO

Acetylglucosamine results in decreased expression of TUBB mRNA

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

G

tubulin gamma complex component 3

decreases expression

ISO

Acetylglucosamine results in decreased expression of TUBGCP3 mRNA

NCBI chr16:76,851,859...76,912,499
Ensembl chr16:76,851,810...76,912,499

G

ubiquitin-conjugating enzyme E2D 3

increases expression

ISO

Acetylglucosamine results in increased expression of UBE2D3 mRNA

NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081

N-ethylmaleimide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases activity

ISO

Ethylmaleimide results in decreased activity of ABCB1 protein

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

affects activity
multiple interactions

ISO

Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]

PMID:9096673 PMID:9334814 PMID:16101123

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

acyl-CoA synthetase long-chain family member 4

decreases activity

EXP

Ethylmaleimide results in decreased activity of ACSL4 protein

NCBI chr X:110,739,633...110,803,416
Ensembl chr X:105,942,799...106,006,427

G

albumin

decreases transport

EXP

Ethylmaleimide results in decreased transport of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

ATPase copper transporting alpha

multiple interactions
increases glutathionylation

ISO

Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein]

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354

G

ATPase phospholipid transporting 8B1

multiple interactions

EXP

Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines]

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

carbonyl reductase 2

increases acylation

ISO

Ethylmaleimide results in increased acylation of CBR2 protein

NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001

G

CF transmembrane conductance regulator

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

choline O-acetyltransferase

decreases activity

ISO

Ethylmaleimide results in decreased activity of CHAT protein

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065

G

dual specificity phosphatase 23

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate]

NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093

G

coagulation factor III, tissue factor

increases expression

ISO

Ethylmaleimide results in increased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

glutamate decarboxylase 1

decreases activity

ISO

Ethylmaleimide results in decreased activity of GAD1 protein

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

decreases activity

ISO

Ethylmaleimide results in decreased activity of GAD2 protein

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

homeo box B13

increases response to substance

ISO

HOXB13 protein results in increased susceptibility to Ethylmaleimide

NCBI chr10:81,160,498...81,162,777
Ensembl chr10:81,160,498...81,162,777

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions

ISO

Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein]

NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899

G

isocitrate dehydrogenase (NADP(+)) 1

decreases activity
multiple interactions

EXP

Ethylmaleimide results in decreased activity of IDH1 protein
isocitric acid inhibits the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]; NADP promotes the reaction [Ethylmaleimide results in decreased activity of IDH1 protein]

NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708

G

interleukin 1 alpha

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

lymphotoxin beta receptor

multiple interactions

ISO

Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein]

NCBI chr 4:159,795,115...159,801,571
Ensembl chr 4:158,108,886...158,121,539

G

mitogen activated protein kinase 1

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

metallothionein 3

increases alkylation

ISO

Ethylmaleimide results in increased alkylation of MT3 protein

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

oncostatin M

multiple interactions

ISO

Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein]

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313

G

phenylalanine hydroxylase

multiple interactions

ISO

Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein]

NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130

G

SUMO specific peptidase 1

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]

NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598

G

SUMO specific peptidase 6

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein]

NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170

G

solute carrier family 12 member 5

increases activity
multiple interactions

ISO

Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]

NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765

G

solute carrier family 16 member 1

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611

G

superoxide dismutase 2

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

Sp1 transcription factor

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein]

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

small ubiquitin-like modifier 2

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein]

NCBI chr10:101,270,899...101,283,458
Ensembl chr10:100,686,797...100,784,513
Ensembl chr 5:100,686,797...100,784,513

G

transferrin

decreases uptake

ISO

Ethylmaleimide results in decreased uptake of TF protein

NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511

G

tyrosine hydroxylase

multiple interactions

EXP

Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions

ISO

Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

voltage-dependent anion channel 1

affects binding

EXP

Ethylmaleimide binds to VDAC1 protein

NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640

G

vitamin K epoxide reductase complex, subunit 1

multiple interactions
decreases activity

EXP

Dithiothreitol promotes the reaction [Ethylmaleimide results in decreased activity of VKORC1 protein]

NCBI chr 1:182,502,491...182,505,012
Ensembl chr 1:182,500,844...182,505,008

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

[omipalisib co-treated with trametinib] results in decreased phosphorylation of AKT1 protein
omipalisib results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

Bcl2-like 11

multiple interactions

ISO

[trametinib co-treated with omipalisib] results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

beclin 1

multiple interactions

ISO

omipalisib inhibits the reaction [RHPN1-AS1 protein results in decreased expression of BECN1 protein]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

caspase 3

multiple interactions

ISO

[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; omipalisib inhibits the reaction [RHPN1-AS1 protein results in decreased expression of CASP3 protein modified form]

PMID:22733540 PMID:36125241

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

ISO

[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

discoidin domain receptor tyrosine kinase 1

multiple interactions

ISO

omipalisib enhances the reaction [DDR1-IN-1 inhibits the reaction [collagen increases DDR1 autophosphorylation in human cell lines]]

RGD

NCBI chr20:3,047,269...3,069,277
Ensembl chr20:3,044,320...3,064,468

G

epidermal growth factor receptor

multiple interactions

ISO

omipalisib inhibits the reaction [RHPN1-AS1 protein results in increased expression of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

ISO

omipalisib results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

G protein subunit alpha q

multiple interactions

ISO

[GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP3 protein; [GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]] which results in increased cleavage of CASP7 protein; GNAQ gene mutant form results in increased susceptibility to [trametinib co-treated with omipalisib]

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[omipalisib co-treated with trametinib] results in increased phosphorylation of JUN protein; JUN results in decreased susceptibility to [omipalisib co-treated with trametinib]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

[omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK1 protein
omipalisib results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

[omipalisib co-treated with trametinib] results in decreased phosphorylation of MAPK3 protein
omipalisib results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

omipalisib inhibits the reaction [RHPN1-AS1 protein results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

poly (ADP-ribose) polymerase 1

decreases phosphorylation
increases cleavage

ISO

omipalisib results in decreased phosphorylation of PARP1 protein
omipalisib results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

ribosomal protein S6

decreases phosphorylation

ISO

omipalisib results in decreased phosphorylation of RPS6 protein

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases phosphorylation

ISO

omipalisib results in decreased phosphorylation of RPS6KB1 protein

PMID:21464613 PMID:22733540

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

ISO

[perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation

ISO

[perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein

PMID:15781658 PMID:21267448 PMID:30265530 PMID:31445927

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

BCL2-antagonist/killer 1

multiple interactions

ISO

[perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

[perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

caspase 3

multiple interactions
decreases expression

ISO

[perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein

PMID:15781658 PMID:25416439

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases expression

ISO

[perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with Vorinostat] results in increased activity of CASP8 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]

PMID:15781658 PMID:32587277

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

perifosine inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cytochrome c, somatic

multiple interactions

ISO

[perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

epidermal growth factor

multiple interactions

ISO

perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

Fas cell surface death receptor

affects response to substance

ISO

perifosine affects the susceptibility to FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

forkhead box O1

multiple interactions

ISO

[perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA
perifosine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of FOXO1 protein]

PMID:30265530 PMID:33078829

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

galactosidase, beta 1

multiple interactions

ISO

perifosine inhibits the reaction [Mitomycin results in increased activity of GLB1 protein]

NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127

G

linker for activation of T cells family, member 2

multiple interactions
decreases response to substance
decreases expression

ISO

ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]
LAT2 protein results in decreased susceptibility to perifosine

PMID:23001822 PMID:32587277

NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase 1

multiple interactions

ISO

[perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

ISO

[perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

ISO

[perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

[perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

tumor necrosis factor

increases response to substance

ISO

perifosine results in increased susceptibility to TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

ISO

perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

ISO

PX-866 results in decreased phosphorylation of AKT1 protein
PX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]

PMID:25805502 PMID:28634229

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

axin 2

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of AXIN2 mRNA

NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231

G

BCL2-associated agonist of cell death

decreases phosphorylation
multiple interactions

ISO

PX-866 results in decreased phosphorylation of BAD protein
[PX-866 co-treated with BBR3610] results in decreased phosphorylation of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

basic helix-loop-helix family, member e40

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of BHLHE40 mRNA

NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:141,618,476...141,624,774

G

calcium/calmodulin-dependent protein kinase kinase 2

affects response to substance

ISO

CAMKK2 protein affects the susceptibility to PX-866

NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279

G

cyclin D1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E2

decreases expression
multiple interactions

ISO

PX-866 results in decreased expression of CCNE2 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCNE2 mRNA

NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632

G

CD36 molecule

multiple interactions

ISO

[PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cell division cycle 6

multiple interactions
decreases expression

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CDC6 mRNA
PX-866 results in decreased expression of CDC6 mRNA

NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

ISO

[PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

E2F transcription factor 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

fatty acid synthase

multiple interactions

ISO

PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

heparin-binding EGF-like growth factor

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of HBEGF mRNA

NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441

G

interleukin 11

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of IL11 mRNA

NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129

G

LIF, interleukin 6 family cytokine

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of LIF mRNA

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

MDM2 proto-oncogene

decreases phosphorylation
multiple interactions

ISO

PX-866 results in decreased phosphorylation of MDM2 protein
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

microsomal triglyceride transfer protein

multiple interactions

ISO

PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

RB transcriptional corepressor 1

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

stearoyl-CoA desaturase

multiple interactions

ISO

PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

sortilin 1

multiple interactions
decreases expression

ISO

[PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA; [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA; PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]; SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides]
PX-866 results in decreased expression of SORT1 protein

NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354

G

telomerase reverse transcriptase

multiple interactions

ISO

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of TERT mRNA

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

sapanisertib results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

Bcl2-like 11

increases expression

ISO

sapanisertib results in increased expression of BCL2L11 mRNA; sapanisertib results in increased expression of BCL2L11 protein

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

caspase 3

increases cleavage

ISO

sapanisertib results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases cleavage

ISO

sapanisertib results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

cyclin D1

decreases expression

ISO

sapanisertib results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

sapanisertib results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

ISO

sapanisertib results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

forkhead box O3

affects localization

ISO

sapanisertib affects the localization of FOXO3 protein

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

sapanisertib results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

sapanisertib results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

marker of proliferation Ki-67

decreases expression
increases cleavage

ISO

sapanisertib results in decreased expression of MKI67 protein
sapanisertib results in increased cleavage of MKI67 protein

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

mechanistic target of rapamycin kinase

decreases phosphorylation

ISO

sapanisertib results in decreased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

ISO

sapanisertib results in decreased expression of MYC protein

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

sapanisertib results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

ribosomal protein S6

decreases expression

ISO

sapanisertib results in decreased expression of RPS6 protein modified form

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

decreases phosphorylation

ISO

sapanisertib results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

triciribine results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

decreases phosphorylation

ISO

triciribine results in decreased phosphorylation of AKT2 protein

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

triciribine inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

caspase 3

multiple interactions
increases expression

ISO

triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
triciribine results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

follicle stimulating hormone subunit beta

decreases activity

ISO

triciribine results in decreased activity of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370

G

H2A.X variant histone

increases expression

ISO

triciribine results in increased expression of H2AX mRNA

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

HRas proto-oncogene, GTPase

multiple interactions

ISO

triciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615

G

insulin 2

multiple interactions

ISO

triciribine inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite]

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

matrix metallopeptidase 2

multiple interactions

ISO

triciribine inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

nitric oxide synthase 2

multiple interactions

EXP

triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases expression

ISO

triciribine inhibits the reaction [epothilone A results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]
triciribine results in increased expression of PARP1 mRNA

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

prohibitin 1

increases expression

EXP

triciribine results in increased expression of PHB1 protein

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

triciribine inhibits the reaction [Mevinphos results in increased activity of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

affects localization
decreases activity
multiple interactions

EXP
ISO

wortmannin affects the localization of ABCB11 protein
wortmannin results in decreased activity of ABCB11 protein
wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]

PMID:12702492 PMID:20815017 PMID:20829430 PMID:23956101

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 2

affects localization
multiple interactions

EXP

wortmannin affects the localization of ABCC2 protein
Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]

PMID:12702492 PMID:20815017 PMID:31300867

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

acyl-CoA oxidase 1

multiple interactions

EXP

wortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232

G

angiotensinogen

multiple interactions

EXP

Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]

PMID:15121739 PMID:15849355 PMID:25398788

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

multiple interactions

EXP

Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

apoptosis inducing factor, mitochondria associated 1

decreases localization

EXP

wortmannin results in decreased localization of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression
decreases reaction
decreases phosphorylation
decreases activity

ISO
EXP

AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; Wortmannin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [bisphenol AF results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL8 results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Hexanones results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Humic Substances results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Hydrocarbons, Chlorinated results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [ochratoxin A results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Trp-Lys-Tyr-Met-Val-Met results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]
[wortmannin cotreatment with isoflurane] decreases expression of AKT1 mRNA,protein in hippocampus
Wortmannin inhibits the reaction [ethanol increases phosphorylation of Akt1 protein in cardiac muscle cells]
Wortmannin inhibits the reaction [Insulin increases activity of Akt1 protein in adipocytes]
wortmannin inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus
wortmannin results in decreased phosphorylation of AKT1 protein
Resveratrol promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Thimerosal promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Wortmannin promotes the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Thimerosal results in decreased phosphorylation of AKT1 protein]; Wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 protein
wortmannin results in decreased expression of AKT1 protein
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [astringin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [hydroxyflutamide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]
wortmannin results in decreased activity of AKT1 protein

CTD
RGD

PMID:11306697 PMID:11340092 PMID:11788791 PMID:12032135 PMID:12388182 More...

RGD:597931096, RGD:408346755, RGD:407420264, RGD:152177689

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

AKT1 substrate 1

multiple interactions
decreases phosphorylation

ISO

wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]
wortmannin results in decreased phosphorylation of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

alkaline phosphatase, intestinal

multiple interactions
increases activity

ISO

wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein]
wortmannin results in increased activity of ALPI protein

NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:87,773,411...87,776,877

G

apolipoprotein B

multiple interactions

EXP

wortmannin inhibits the reaction [[bisphenol A results in decreased expression of APOB mRNA] which results in decreased abundance of Triglycerides]; wortmannin inhibits the reaction [bisphenol A results in decreased expression of APOB mRNA]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

amyloid beta precursor protein

increases expression

EXP

[wortmannin cotreatment with isoflurane] increases expression of APP protein in hippocampus

RGD

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

amphiregulin

decreases activity

EXP

wortmannin results in decreased activity of AREG protein

NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

EXP

wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

activating transcription factor 2

multiple interactions

EXP

Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of ATF2 protein]

NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236

G

ATM serine/threonine kinase

multiple interactions

ISO

wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein]
ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]

PMID:15489221 PMID:20888899 PMID:22119920

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

beta-secretase 1

increases expression

EXP

[wortmannin cotreatment with isoflurane] increases expression of Bace1 mRNA, protein in hippocampus

RGD

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

multiple interactions
decreases phosphorylation

ISO
EXP

wortmannin inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]
wortmannin results in decreased phosphorylation of BAD protein
Wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]; Wortmannin inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and affects the localization of BAD protein]

PMID:15190125 PMID:15608143 PMID:15786717 PMID:19596284

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO
EXP

Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of BAX protein]]

PMID:15142122 PMID:15970427 PMID:31173752 PMID:32805344

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCAR1 scaffold protein, Cas family member

multiple interactions

ISO

[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein]

NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907

G

BCL2, apoptosis regulator

multiple interactions

ISO
EXP

Wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]
Wortmannin inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with Magnesium deficiency] results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]

PMID:15142122 PMID:19703415 PMID:21410490 PMID:30542433 PMID:31173752

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

ISO

wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

brain-derived neurotrophic factor

multiple interactions

ISO
EXP

wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]]

PMID:17209049 PMID:32805344

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions
decreases expression

ISO
EXP

wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein]
wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein]
wortmannin results in decreased expression of BECN1 protein

PMID:21410490 PMID:23604964

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

baculoviral IAP repeat-containing 2

multiple interactions
decreases expression

ISO

wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein]
wortmannin results in decreased expression of BIRC2 mRNA; wortmannin results in decreased expression of BIRC2 protein

PMID:15065019 PMID:19596284

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

multiple interactions

ISO

wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression
multiple interactions

ISO

wortmannin results in decreased expression of BIRC5 mRNA; wortmannin results in decreased expression of BIRC5 protein
wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein]
wortmannin promotes the reaction [resveratrol results in decreased expression of BIRC5 protein]

PMID:15065019 PMID:18025287 PMID:22137261 PMID:23145070

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

complement C5

multiple interactions

ISO

wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]; wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]

NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994

G

caspase 1

increases cleavage

ISO

wortmannin results in increased cleavage of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases expression
increases cleavage
decreases activity

ISO
EXP

ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP3 protein]
[wortmannin cotreatment with isoflurane] increases expression of caspase3 mRNA,protein in hippocampus
wortmannin results in increased cleavage of CASP3 protein
[Rotenone co-treated with wortmannin] results in increased cleavage of CASP3 protein; Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [resveratrol results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein]
wortmannin results in decreased activity of CASP3 protein

CTD
RGD

PMID:15142122 PMID:15695173 PMID:17935137 PMID:20104024 PMID:21256120 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

ISO

wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions

ISO
EXP

ABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]

PMID:20104024 PMID:24726520

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage

ISO
EXP

ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
wortmannin results in increased cleavage of CASP9 protein
Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP9 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP9 protein]
wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP9 protein]

PMID:17935137 PMID:20104024 PMID:22137261 PMID:23145070 PMID:24726520

Ensembl chr 5:154,109,046...154,126,626

G

caveolin 1

multiple interactions

ISO

wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide]; wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite]

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 2

multiple interactions

ISO

wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

ISO

wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]

PMID:19016906 PMID:22225513

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

cyclin A2

multiple interactions

ISO

wortmannin inhibits the reaction [Vanadates results in increased expression of CCNA2 protein]

NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

multiple interactions

ISO

[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
decreases expression

ISO
EXP

Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CCND1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 mRNA]
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased expression of CCND1 protein]]; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein]
wortmannin results in decreased expression of CCND1 protein

PMID:15695173 PMID:18353414 PMID:19801633 PMID:28321046 PMID:30542433 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases methylation
increases expression

ISO

wortmannin results in decreased methylation of CCND2 promoter
wortmannin results in increased expression of CCND2 mRNA

NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

affects localization
multiple interactions

ISO

wortmannin affects the localization of CCND3 protein
[wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein; wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]

PMID:10849422 PMID:17129604

NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

multiple interactions

ISO

wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein]
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]

PMID:14971663 PMID:26385184

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

C-C motif chemokine receptor 3

multiple interactions

ISO

wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]

NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990

G

C-C motif chemokine receptor 5

multiple interactions

ISO

wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]

NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260

G

CD36 molecule

multiple interactions

ISO

wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

cell division cycle 25A

multiple interactions
decreases expression

ISO

Imatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein]

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 5-like

multiple interactions

EXP

wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cadherin 1

increases expression

ISO

wortmannin results in increased expression of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions

ISO

Wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]; Wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein]

NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167

G

cyclin-dependent kinase 1

multiple interactions

ISO

[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]

PMID:18025287 PMID:26385184

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

decreases activity
multiple interactions
decreases expression

ISO

wortmannin results in decreased activity of CDK2 protein
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]
wortmannin results in decreased expression of CDK2 protein

PMID:17129604 PMID:26385184

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions

ISO

Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CDK4 protein]

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
decreases expression
increases expression

ISO

wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein]; wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein]
wortmannin results in decreased expression of CDKN1A protein
wortmannin results in increased expression of CDKN1A protein

PMID:15695173 PMID:17129604 PMID:20878124 PMID:21617849 PMID:22290291

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

ISO

wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]; wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]
Imatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]

PMID:17129604 PMID:17935137

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

CF transmembrane conductance regulator

multiple interactions

ISO

wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756

G

checkpoint kinase 1

multiple interactions
decreases expression

ISO

wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein]
wortmannin results in decreased expression of CHEK1 protein

PMID:19261750 PMID:22119920 PMID:22409540

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

multiple interactions
decreases phosphorylation

ISO

wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein]
wortmannin results in decreased phosphorylation of CHEK2 protein

PMID:19111594 PMID:22119920

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

creatine kinase B

decreases reaction

EXP

wortmannin inhibits the reaction [estrogen increases expression of Ckb mRNA] in rat uterus

RGD

NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315

G

clusterin

multiple interactions

ISO

wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein]

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315

G

collagen type XVIII alpha 1 chain

multiple interactions

ISO

wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 2 chain

multiple interactions

ISO

wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

carnitine palmitoyltransferase 1A

multiple interactions

EXP

wortmannin inhibits the reaction [bisphenol A results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055

G

cAMP responsive element binding protein 1

multiple interactions

ISO

wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]

PMID:15608143 PMID:22952890 PMID:23626723

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

C-reactive protein

multiple interactions

ISO

wortmannin inhibits the reaction [Dust analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Dust results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions results in increased expression of CRP mRNA]

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 2

multiple interactions

ISO

wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

catenin beta 1

decreases expression
increases phosphorylation
multiple interactions

ISO

wortmannin results in decreased expression of CTNNB1 protein
wortmannin results in increased phosphorylation of CTNNB1 protein
wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein]; wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]

PMID:11739494 PMID:28163245 PMID:28321046

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 1

multiple interactions

EXP

wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO
EXP

wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein]
wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL2 protein]

PMID:15608143 PMID:20117814

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 2

multiple interactions

ISO

wortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein]

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome c, somatic

decreases secretion

EXP

wortmannin results in decreased secretion of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

EXP

wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

EXP
ISO

wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]

PMID:26466350 PMID:29724254

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

EXP
ISO

wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]

PMID:26466350 PMID:29724254

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP
ISO

wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]
Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]

PMID:11306697 PMID:22486562

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage inducible transcript 3

multiple interactions

ISO

wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

ISO

wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:228,381,521...228,385,202

G

DNA methyltransferase 3 alpha

multiple interactions

ISO

wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]

NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

multiple interactions

ISO

wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein]

NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124

G

DNA methyltransferase 3 like

multiple interactions

ISO

wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein]

NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516

G

E2F transcription factor 1

multiple interactions

ISO

wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein]

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

endothelin 1

multiple interactions

ISO

wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]

NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885

G

eukaryotic translation elongation factor 1 alpha 2

multiple interactions
increases expression

ISO

[Wortmannin co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of EEF1A2 protein
Wortmannin results in increased expression of EEF1A2 protein

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

epidermal growth factor

multiple interactions

ISO
EXP

[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]
Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose]

PMID:15691865 PMID:15849355 PMID:25856345 PMID:26385184

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

ISO

Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of EGFR mRNA]
wortmannin inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]

PMID:15177934 PMID:21568938 PMID:25856345 PMID:36190352

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions

ISO

Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of EIF4EBP1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form]

PMID:12569580 PMID:20936651 PMID:32802178

NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984

G

ETS transcription factor ELK1

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of ELK1 mRNA]

PMID:36190352 PMID:37992829

NCBI chr X:3,692,367...3,709,252
Ensembl chr X:1,139,756...1,155,713

G

erythropoietin receptor

multiple interactions

ISO

wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]

NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:20,489,678...20,494,257

G

estrogen receptor 1

decreases reaction

EXP

wortmannin inhibits the reaction [estrogen increases expression of Esr1 mRNA] in rat uterus

RGD

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor III, tissue factor

multiple interactions

ISO

wortmannin promotes the reaction [Histamine results in increased expression of F3]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

Fas cell surface death receptor

affects response to substance

ISO

Wortmannin affects the susceptibility to FAS protein

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

ISO

wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein]

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 1

decreases activity
multiple interactions

ISO
EXP

wortmannin results in decreased activity of FGF1 protein
wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]

PMID:15121739 PMID:15695173

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 7

multiple interactions

ISO

wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA]

NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929

G

FKBP prolyl isomerase 1A

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FKBP1A mRNA]

PMID:36190352 PMID:37992829

NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743

G

filamin A

multiple interactions

ISO

wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]

NCBI chr X:157,159,051...157,185,559
Ensembl chr X:152,007,758...152,031,052

G

Fms related receptor tyrosine kinase 3 ligand

multiple interactions

ISO

wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]

NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP
ISO

wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]
Wortmannin inhibits the reaction [Dieldrin results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS protein]

PMID:11687581 PMID:31068361 PMID:33582643 PMID:36190352 PMID:37992829

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O1

multiple interactions

ISO

wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein]
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOXO1 mRNA]

PMID:16973122 PMID:17935137 PMID:20936651 PMID:24024143 PMID:37992829

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

multiple interactions
decreases phosphorylation

ISO

Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]
wortmannin results in decreased phosphorylation of FOXO3 protein

PMID:17935137 PMID:20936651 PMID:23673518 PMID:24024143 PMID:25856345

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

forkhead box O4

multiple interactions

ISO

wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO4 protein]

NCBI chr X:70,425,218...70,432,120
Ensembl chr X:66,385,558...66,392,115

G

forkhead box P1

decreases expression

ISO

wortmannin results in decreased expression of FOXP1 protein

NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370

G

follicle stimulating hormone receptor

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FSHR mRNA]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

ferritin heavy chain 1

multiple interactions

ISO

wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

ISO

Wortmannin results in increased expression of G6PC1 mRNA
Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804

G

gastrin

decreases secretion

EXP

wortmannin results in decreased secretion of GAST protein

NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

ISO

wortmannin results in increased expression of GDF15 protein

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055

G

gap junction protein, alpha 1

multiple interactions

EXP

wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein]

NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582

G

glucagon-like peptide 1 receptor

multiple interactions

EXP

wortmannin inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]

NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241

G

gonadotropin releasing hormone 1

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of GNRH1 mRNA]

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

G protein-coupled estrogen receptor 1

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of GPER1 mRNA]

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889

G

G protein-coupled receptor kinase 2

multiple interactions

EXP

wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]]

NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582

G

granulin precursor

multiple interactions

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]; wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]

NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775

G

glycogen synthase kinase 3 alpha

multiple interactions

ISO

Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]]

NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802

G

glycogen synthase kinase 3 beta

multiple interactions
decreases phosphorylation
decreases expression

ISO
EXP

Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]]; Wortmannin inhibits the reaction [Bortezomib results in decreased activity of and results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]
wortmannin results in decreased phosphorylation of GSK3B protein
wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [rosiglitazone results in increased phosphorylation of GSK3B protein]
wortmannin results in decreased expression of GSK3B protein modified form
Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; Vitamin E inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]

PMID:12614848 PMID:15842767 PMID:16076840 PMID:17513037 PMID:18040759 More...

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646

G

H2A.X variant histone

multiple interactions

ISO

Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; Wortmannin inhibits the reaction [Decitabine results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Docetaxel results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AX protein]

PMID:17991895 PMID:20878124 PMID:22409540 PMID:34784199

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases reaction
decreases expression

ISO
EXP

[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]
wortmannin inhibits the reaction [estrogen increases expression of Hif1a mRNA] in rat uterus
wortmannin results in decreased expression of HIF1A protein

CTD
RGD

PMID:11424089 PMID:13679210 PMID:14726529 PMID:15050414 PMID:16499871 More...

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group box 1

multiple interactions

ISO

wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein]

NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

multiple interactions

ISO
EXP

Wortmannin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]
Wortmannin inhibits the reaction [astringin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]
Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]

PMID:17535857 PMID:18048804 PMID:20028456 PMID:20117814 PMID:22022464 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

heat shock transcription factor 1

affects localization
multiple interactions

ISO

wortmannin affects the localization of HSF1 protein
wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]

PMID:11424089 PMID:20090934

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein family A (Hsp70) member 1A

decreases expression

ISO

wortmannin results in decreased expression of HSPA1A protein; wortmannin results in decreased expression of HSPA1A protein alternative form

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO

wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

EXP
ISO

wortmannin inhibits the reaction [resveratrol results in decreased activity of ICAM1 protein]
wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]

PMID:20117814 PMID:23114885

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon beta 1

multiple interactions

ISO

wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]

NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523

G

interferon gamma

multiple interactions

ISO

wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]

PMID:16968468 PMID:25352548

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

ISO
EXP

[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]]
wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]

PMID:12569580 PMID:14745455 PMID:16499871 PMID:16682453 PMID:17520698 More...

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

decreases response to substance
multiple interactions

ISO

wortmannin results in decreased susceptibility to IGF2 protein
wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018

G

interleukin 12A

multiple interactions

ISO

Wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

ISO

wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903

G

interleukin 17A

multiple interactions

ISO

wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 18

multiple interactions

ISO

wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

ISO

wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

ISO
EXP

wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
[wortmannin cotreatment with isoflurane] increases expression of IL1b protein in hippocampus
Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]

CTD
RGD

PMID:16359550 PMID:22952890 PMID:25352548 PMID:30221701

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

decreases expression

ISO

wortmannin results in decreased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 23 subunit alpha

multiple interactions

ISO

wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]

NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923

G

interleukin 3

multiple interactions

ISO

Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]

PMID:11544337 PMID:23001822

NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066

G

interleukin 4

multiple interactions

EXP

Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of and results in increased secretion of IL4 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression

EXP
ISO

wortmannin inhibits the reaction [resveratrol results in decreased activity of IL6 protein]
[wortmannin cotreatment with isoflurane] increases expression of IL6 protein in hippocampus
[4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]
wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]

CTD
RGD

PMID:20117814 PMID:24631921 PMID:30217479 PMID:30221701

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

ISO
EXP

Wortmannin inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased transport of Sodium]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Wortmannin inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; Wortmannin inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]]
Wortmannin inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid]

PMID:9877156 PMID:11306697 PMID:15172182 PMID:17962351 PMID:18591783 More...

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536

G

insulin 2

multiple interactions

ISO
EXP

[Wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]; Wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]
wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]

PMID:11574405 PMID:17550345 PMID:17728140 PMID:20015842 PMID:20936651 More...

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

insulin receptor

multiple interactions

EXP

Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]]

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883

G

interleukin-1 receptor-associated kinase 3

decreases expression

ISO

wortmannin results in decreased expression of IRAK3 mRNA

NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121

G

insulin receptor substrate 1

multiple interactions

ISO
EXP

wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]]

PMID:20936651 PMID:32805344

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122

G

integrin subunit alpha V

multiple interactions

ISO

wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]

NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639

G

integrin subunit beta 2

multiple interactions

ISO

wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600

G

integrin subunit beta 3

multiple interactions

ISO

wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]

NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679

G

potassium voltage-gated channel subfamily H member 1

multiple interactions

ISO

wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]

NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740

G

KIT ligand

multiple interactions

ISO

wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]; wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]
wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]

PMID:10849422 PMID:23001822

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

KLF transcription factor 4

multiple interactions

EXP

wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein]

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

KLF transcription factor 6

decreases expression
multiple interactions

ISO

Wortmannin results in decreased expression of KLF6 mRNA
Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

G

kininogen 1

multiple interactions

EXP

KNG1 protein inhibits the reaction [[Wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; Wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein]

NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555

G

linker for activation of T cells family, member 2

multiple interactions

ISO

wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]

NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288

G

leptin

decreases expression
multiple interactions
decreases secretion

ISO

wortmannin results in decreased expression of LEP mRNA
wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium]
wortmannin results in decreased secretion of LEP protein

PMID:19254925 PMID:20107083

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of LHR mRNA]

NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521

G

DNA ligase 1

multiple interactions

ISO

wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]

NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
decreases expression

ISO

wortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein]
wortmannin results in decreased expression of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

ISO
EXP

[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [bisphenol AF results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]
Wortmannin inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK1 protein]
wortmannin results in decreased phosphorylation of MAPK1 protein
wortmannin results in increased phosphorylation of MAPK1 protein
Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]

PMID:10611455 PMID:15086530 PMID:15177934 PMID:15287886 PMID:15355987 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

ISO

wortmannin promotes the reaction [Tretinoin results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

ISO
EXP

[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [bisphenol AF results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK3 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]
Wortmannin inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK3 protein]
wortmannin results in decreased phosphorylation of MAPK3 protein
wortmannin results in increased phosphorylation of MAPK3 protein
Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]

PMID:10611455 PMID:15086530 PMID:15177934 PMID:15287886 PMID:15355987 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 6

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK6 mRNA]

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

mitogen-activated protein kinase 8

multiple interactions
decreases phosphorylation

ISO
EXP

wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein]
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK8 mRNA]
Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK8 protein]
wortmannin results in decreased phosphorylation of MAPK8 protein

PMID:10611455 PMID:18950629 PMID:36190352

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

EXP

Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

multiple interactions
increases phosphorylation

ISO

Melatonin inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]; Vitamin E inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]
Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]]

PMID:15842767 PMID:31173752

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

ISO

AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased stability of and results in decreased ubiquitination of MCL1 protein]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; Wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein]; Wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein]
wortmannin results in decreased expression of MCL1 protein

PMID:15970427 PMID:17935137 PMID:23353698 PMID:32802178

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303

G

MDM2 proto-oncogene

multiple interactions

ISO

wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]; wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

microRNA 200a

multiple interactions

ISO

[wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA

NCBI chr 5:166,648,494...166,648,582

G

microRNA 21

multiple interactions

ISO

wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]

PMID:23052036 PMID:25969534

NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348

G

microRNA 22

multiple interactions

ISO

[wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA

NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133

G

matrix metallopeptidase 12

multiple interactions

ISO

wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 14

multiple interactions

ISO

Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of MMP14 protein]

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 2

multiple interactions
decreases expression

ISO

brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin results in decreased expression of and results in decreased activity of MMP2 protein
wortmannin results in decreased expression of MMP2

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
decreases activity

EXP
ISO

wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein]
wortmannin results in decreased activity of MMP9 protein
wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]; wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]

PMID:20195827 PMID:22033475 PMID:23288142 PMID:24333868

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

ISO
EXP

Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]
wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein]

PMID:18987595 PMID:20117814 PMID:26262998

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

membrane spanning 4-domains A2

multiple interactions
decreases response to substance

ISO

MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]]
MS4A2 protein mutant form results in decreased susceptibility to wortmannin

NCBI chr 1:217,864,855...217,873,934
Ensembl chr 1:208,440,361...208,448,310

G

metallothionein 1

multiple interactions

ISO

Wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 3

decreases response to substance

ISO

wortmannin results in decreased susceptibility to MT3 protein

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MTOR protein]

PMID:19139269 PMID:32802178 PMID:36288207

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

ISO

Wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]

NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of MYC protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC mRNA]

PMID:33582643 PMID:36190352 PMID:36288207 PMID:37992829

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630

G

MYCN proto-oncogene, bHLH transcription factor

multiple interactions

ISO

wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]

NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590

G

myosin heavy chain 4

multiple interactions

ISO

Wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]

NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295

G

myosin light chain 7

multiple interactions
decreases phosphorylation

ISO

wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein]
wortmannin results in decreased phosphorylation of MYL7 protein

NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244

G

nuclear receptor coactivator 4

multiple interactions

ISO

Wortmannin inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein]

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

neuronal calcium sensor 1

multiple interactions

EXP

wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate]

NCBI chr 3:34,920,949...34,966,554
Ensembl chr 3:14,523,220...14,568,829

G

N-myc downstream regulated 1

decreases phosphorylation
multiple interactions

ISO

wortmannin results in decreased phosphorylation of NDRG1 protein
wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]

NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880

G

NEDD4 E3 ubiquitin protein ligase

multiple interactions

EXP

wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]

NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

ISO

Wortmannin inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein]
wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]

PMID:15142122 PMID:17935137 PMID:20005289 PMID:23170834 PMID:24085292

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions
decreases activity

ISO
EXP

wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein]; wortmannin inhibits the reaction [NGF results in increased susceptibility to Capsaicin]
wortmannin results in decreased activity of NGF protein
wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]; wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]

PMID:12815188 PMID:16319926 PMID:17324588 PMID:20629186 PMID:21975456

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

Carvedilol promotes the reaction [Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]
wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]

PMID:12839867 PMID:17159805 PMID:22952890 PMID:24462917 PMID:25352548

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
decreases phosphorylation

ISO
EXP

Fenofibrate inhibits the reaction [wortmannin results in decreased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [diallyl trisulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]
wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein]

PMID:11788791 PMID:15358673 PMID:16442496 PMID:18296501 PMID:18317400 More...

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 1

multiple interactions

ISO

wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]

NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]

PMID:20028456 PMID:34077701

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 5, group A, member 1

multiple interactions

ISO

wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]

NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328

G

neurotrophin 3

decreases transport

ISO

wortmannin results in decreased transport of NTF3 protein

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596

G

neurotrophin 4

decreases transport

ISO

wortmannin results in decreased transport of NTF4 protein

NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:95,893,457...95,897,243

G

neurotensin

multiple interactions

ISO

wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423

G

proliferation-associated 2G4

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of PA2G4 mRNA]

NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [sodium arsenite results in increased degradation of PARP1 protein]
wortmannin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]

PMID:12614848 PMID:17935137 PMID:22155090 PMID:32802178 PMID:34291863

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

EXP

[troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191

G

programmed cell death 4

increases expression

ISO

Wortmannin results in increased expression of PDCD4 mRNA; Wortmannin results in increased expression of PDCD4 protein

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275

G

pyruvate dehydrogenase kinase 1

multiple interactions

ISO

wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of PDK1 protein]

NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038

G

pancreatic and duodenal homeobox 1

multiple interactions

ISO

wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]
[wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]

PMID:9873045 PMID:11574405

NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064

G

PDZ domain containing 1

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of PDZK1 mRNA]

PMID:36190352 PMID:37992829

NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514

G

progesterone receptor

decreases reaction

EXP

wortmannin inhibits the reaction [estrogen increases expression of Pgr mRNA] in rat uterus

RGD

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions
decreases activity

ISO

wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein]
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of PIK3CA protein]
wortmannin results in decreased activity of PIK3CA protein

PMID:16227402 PMID:19036708 PMID:36288207

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

decreases activity
decreases expression
multiple interactions

ISO
EXP

wortmannin results in decreased activity of PIK3CB protein
[wortmannin cotreatment with isoflurane] decreases expression of PI3K mRNA,protein in hippocampus
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of PIK3CB protein]

CTD
RGD

PMID:11931710 PMID:36288207 PMID:30221701

NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta

decreases activity

ISO

wortmannin results in decreased activity of PIK3CD protein

NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

multiple interactions
decreases activity

ISO
EXP

wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]
wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]]
wortmannin results in decreased activity of PIK3CG protein

PMID:15178407 PMID:21644799 PMID:28759639

NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043

G

phosphoinositide-3-kinase regulatory subunit 1

decreases activity
multiple interactions

ISO
EXP

wortmannin results in decreased activity of PIK3R1 protein
Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA]]

PMID:19036708 PMID:27832966 PMID:32805344

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631

G

placenta enriched 1

multiple interactions

ISO

wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA]

NCBI chr X:132,821,347...132,955,143
Ensembl chr X:132,821,347...132,985,668

G

phospholamban

multiple interactions

EXP

wortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]

NCBI chr20:33,166,512...33,182,241

G

periostin

multiple interactions

EXP

wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP

wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

EXP

wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA]

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

multiple interactions

EXP

wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA]

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

multiple interactions

ISO

wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein]

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

multiple interactions

ISO

wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]

NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775

G

protein kinase C, delta

multiple interactions

ISO

wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]

PMID:11424089 PMID:17171638

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protein kinase, DNA-activated, catalytic subunit

multiple interactions

ISO

PRKDC protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952

G

pre-mRNA processing factor 19

multiple interactions

EXP

wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]

NCBI chr 1:216,966,104...216,977,549
Ensembl chr 1:207,541,595...207,552,662

G

phosphatase and tensin homolog

multiple interactions

ISO
EXP

Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]; Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]; Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of PTEN mRNA]
Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA]]; Wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased ubiquitination of PTEN protein]

PMID:17935137 PMID:20100827 PMID:27832966 PMID:32805344 PMID:36190352

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E receptor 1

multiple interactions

ISO

wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]

NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]

PMID:15980035 PMID:18089846 PMID:18840457 PMID:22952890 PMID:23968725

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

ISO
EXP

[Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]; oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [Testosterone results in increased phosphorylation of PTK2 protein]
[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein]

PMID:10537051 PMID:16038899

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

paxillin

multiple interactions

ISO

[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein]

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

G

RAD23 homolog B, nucleotide excision repair protein

multiple interactions

ISO

wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]

NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319

G

RAD50 double strand break repair protein

multiple interactions

ISO

[wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

ISO

wortmannin promotes the reaction [hydroxyflutamide results in increased phosphorylation of RAF1 protein]; wortmannin promotes the reaction [ON123300 results in increased phosphorylation of RAF1 protein]

PMID:24568969 PMID:28163245

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317

G

RAP1A, member of RAS oncogene family

multiple interactions

ISO

wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]

NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501

G

RB transcriptional corepressor 1

multiple interactions

ISO
EXP

wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]; wortmannin inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein]
Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of RB1 protein]]; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein]

PMID:10849422 PMID:14971663 PMID:18353414 PMID:30542433

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

REL proto-oncogene, NF-kB subunit

multiple interactions

ISO

wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]
Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of RELA protein]]

PMID:17982072 PMID:18207479 PMID:24462917 PMID:32805344

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal oxygenase 2

multiple interactions

ISO

wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]

NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574

G

ribosomal protein S6

multiple interactions

ISO

Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]

PMID:20335389 PMID:23001822

NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

multiple interactions
decreases phosphorylation

EXP
ISO

wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein]
Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of RPS6KB1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]
wortmannin results in decreased phosphorylation of RPS6KB1 protein
wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein]

PMID:14516795 PMID:20936651 PMID:21195169 PMID:25663935 PMID:32802178

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

ribosomal protein S6 kinase B2

multiple interactions

ISO

wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]

NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078

G

secretogranin II

decreases activity

ISO

wortmannin results in decreased activity of SCG2 protein alternative form

NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097

G

secretin

multiple interactions

EXP

wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]

NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658

G

selenoprotein P

increases expression

ISO

wortmannin results in increased expression of SELENOP protein

NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:52,498,339...52,508,852

G

serpin family E member 1

multiple interactions

ISO

wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

serpin family H member 1

multiple interactions

ISO

wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein]

NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:153,643,510...153,650,801

G

surfactant protein C

decreases expression

ISO

wortmannin results in decreased expression of SFTPC protein

NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777

G

serum/glucocorticoid regulated kinase 1

multiple interactions

ISO

wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of SGK1 protein]

NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283

G

sex hormone binding globulin

multiple interactions

EXP

wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA]

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057

G

signal-regulatory protein alpha

multiple interactions

ISO

wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]

NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:116,819,726...116,858,098

G

sirtuin 1

multiple interactions

ISO

wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]

PMID:18298901 PMID:22952890

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 1 member 1

multiple interactions
decreases activity

EXP

wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein]
wortmannin results in decreased activity of SLC1A1 protein

PMID:16150575 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585

NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402

G

solute carrier family 2 member 4

multiple interactions

EXP
ISO

Wortmannin inhibits the reaction [4-hydroxyisoleucine results in increased localization of SLC2A4 protein]; Wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein]
wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]

PMID:11978788 PMID:18591783 PMID:22610671

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 2 member 5

multiple interactions

EXP

wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]

NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 5 member 5

multiple interactions

ISO

wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]]

NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697

G

solute carrier family 6 member 3

multiple interactions

ISO

wortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413

G

suppressor of cytokine signaling 3

multiple interactions

ISO

wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 2

increases expression

EXP

wortmannin results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sortilin 1

multiple interactions
increases ubiquitination

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]; wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; wortmannin results in decreased expression of and results in increased degradation of SORT1 protein
wortmannin results in increased ubiquitination of SORT1 protein

NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354

G

Sp1 transcription factor

multiple interactions
decreases reaction

ISO
EXP

wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein]
wortmannin inhibits the reaction [estrogen increases expression of Sp1 mRNA] in rat uterus

CTD
RGD

PMID:17441964 PMID:17272396

NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961

G

sequestosome 1

multiple interactions
increases expression
decreases expression

ISO

[wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein
wortmannin results in increased expression of SQSTM1 protein
wortmannin results in decreased expression of SQSTM1 protein

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476

G

sterol regulatory element binding transcription factor 1

multiple interactions

EXP

Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]

PMID:22031849 PMID:25398788

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

serum response factor

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of SRF mRNA]

PMID:36190352 PMID:37992829

NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:14,426,472...14,435,733

G

steroidogenic acute regulatory protein

multiple interactions

EXP

wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672

G

steroid sulfatase

multiple interactions

ISO

wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]; wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]; wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]; wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]

PMID:16178010 PMID:24055520

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

telomerase reverse transcriptase

multiple interactions

ISO

Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]

NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561

G

trefoil factor 1

multiple interactions

ISO

Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of TFF1 mRNA]

PMID:36190352 PMID:37992829

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

TGFB-induced factor homeobox 1

multiple interactions

ISO

wortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]

NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802

G

tyrosine hydroxylase

multiple interactions

ISO
EXP

wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA]
[wortmannin co-treated with manganese chloride] results in decreased expression of TH protein

PMID:18950629 PMID:23604964

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767

G

thyroid hormone receptor alpha

multiple interactions

ISO

wortmannin binds to and results in decreased activity of THRA protein

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936

G

TIMP metallopeptidase inhibitor 2

multiple interactions

ISO

wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611

G

tight junction protein 1

multiple interactions

ISO

wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

multiple interactions
increases response to substance

ISO
EXP

Wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Wortmannin inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; Wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
Wortmannin results in increased susceptibility to TNF protein
Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]
Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]

PMID:12805067 PMID:12839867 PMID:16458614 PMID:16968468 PMID:17464197 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions
decreases phosphorylation

ISO
EXP

Wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; Wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; Wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein
wortmannin results in decreased phosphorylation of TP53 protein
wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; wortmannin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]

PMID:11751435 PMID:12676607 PMID:15489221 PMID:15837074 PMID:16024610 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p73

multiple interactions

ISO

wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]; wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein]

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128

G

tripeptidyl peptidase 2

multiple interactions

ISO

wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein]

NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions

ISO

wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein]

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513

G

thioredoxin reductase 1

multiple interactions

ISO

Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

tyrosinase

multiple interactions

ISO

[Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR protein
[Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

G

ubiquitin specific peptidase 7

multiple interactions

ISO

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]

NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355

G

vascular endothelial growth factor A

multiple interactions
decreases secretion
decreases reaction

ISO
EXP

[4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of VEGFA mRNA]
Wortmannin results in decreased secretion of VEGFA protein
wortmannin inhibits the reaction [estrogen increases expression of Vegfa mRNA] in rat uterus

CTD
RGD

PMID:13679210 PMID:15050414 PMID:16499871 PMID:18252963 PMID:18790786 More...

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

decreases expression

ISO

wortmannin results in decreased expression of VIM protein

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

X-ray repair cross complementing 5

multiple interactions

ISO

[wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

X-ray repair cross complementing 6

multiple interactions

ISO

[wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein

NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:113,543,057...113,563,762

G

Yes1 associated transcriptional regulator

multiple interactions

ISO

wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]; wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form]

NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

multiple interactions

EXP

wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

zinc finger protein 143

multiple interactions

ISO

wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]

NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of A2M mRNA

NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily A member 8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ABCA8B mRNA

NCBI chr10:95,416,984...95,490,647
Ensembl chr10:94,917,520...94,990,988

G

abhydrolase domain containing 14b

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ABHD14B mRNA]

NCBI chr 8:115,966,792...115,970,829
Ensembl chr 8:107,088,069...107,092,119

G

aconitate decarboxylase 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ACOD1 mRNA

NCBI chr15:79,871,819...79,881,101
Ensembl chr15:79,871,827...79,880,529

G

actin alpha 2, smooth muscle

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ACTA2 mRNA]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

actin gamma 2, smooth muscle

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ACTG2 mRNA

NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465

G

ADAM metallopeptidase domain 8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ADAM8 mRNA

NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:194,770,060...194,788,801

G

adenylate cyclase 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADCY5 mRNA

NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974

G

ADCYAP receptor type I

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADCYAP1R1 mRNA

NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700

G

adhesion G protein-coupled receptor A2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADGRA2 mRNA

NCBI chr16:64,932,964...64,971,433
Ensembl chr16:64,933,315...64,971,483

G

adhesion G protein-coupled receptor G3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ADGRG3 mRNA

NCBI chr19:9,978,450...10,007,145
Ensembl chr19:9,972,430...10,001,123

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

adenosine A1 receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

AGBL carboxypeptidase 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AGBL1 mRNA

NCBI chr 1:130,043,914...130,950,739
Ensembl chr 1:130,043,970...130,951,638

G

angiotensin II receptor, type 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AGTR2 mRNA

NCBI chr X:116,914,320...116,918,504
Ensembl chr X:112,120,228...112,124,057

G

aldo-keto reductase family 1, member D1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of AKR1D1 mRNA

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

alpha-1-microglobulin/bikunin precursor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of AMBP mRNA

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

amine oxidase, copper containing 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AOC3 mRNA

NCBI chr10:86,272,757...86,280,702

G

apolipoprotein C2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of APOC2 mRNA

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476

G

Rho GTPase activating protein 36

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ARHGAP36 mRNA

NCBI chr X:128,780,148...128,787,169
Ensembl chr X:128,751,900...128,787,161

G

Rho guanine nucleotide exchange factor 19

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ARHGEF19 mRNA]

NCBI chr 5:153,536,038...153,554,203
Ensembl chr 5:153,536,013...153,554,203

G

armadillo repeat containing, X-linked 6

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ARMCX6 mRNA]

NCBI chr X:97,929,032...97,932,031
Ensembl chr X:97,929,041...97,931,977

G

ankyrin repeat and SOCS box-containing 10

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ASB10 mRNA

NCBI chr 4:10,630,318...10,644,270
Ensembl chr 4:10,630,448...10,639,060

G

ankyrin repeat and SOCS box-containing 13

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ASB13 mRNA]

NCBI chr17:66,564,653...66,583,365
Ensembl chr17:66,562,434...66,583,337

G

ankyrin repeat and SOCS box-containing 16

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ASB16 mRNA

NCBI chr10:87,225,976...87,233,078
Ensembl chr10:87,225,912...87,233,078

G

achaete-scute family bHLH transcription factor 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ASCL2 mRNA]

NCBI chr 1:207,578,447...207,665,126
Ensembl chr 1:198,148,999...198,151,406

G

ATPase Na+/K+ transporting subunit alpha 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ATP1A2 mRNA

NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544

G

ATPase Na+/K+ transporting subunit alpha 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of ATP1A3 mRNA

NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918

G

arginine vasopressin receptor 1A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of AVPR1A mRNA

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

G

beta-1,4-N-acetyl-galactosaminyl transferase 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of B4GALNT2 mRNA

NCBI chr10:80,801,594...80,828,005
Ensembl chr10:80,802,941...80,857,700

G

BEN domain containing 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of BEND4 mRNA

NCBI chr14:40,753,048...40,788,686
Ensembl chr14:40,753,077...40,783,504

G

basic helix-loop-helix family, member a15

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BHLHA15 mRNA

NCBI chr12:15,534,123...15,538,299
Ensembl chr12:10,420,467...10,424,713

G

BPI fold containing family A, member 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of BPIFA5 mRNA

NCBI chr 3:142,646,103...142,652,884
Ensembl chr 3:142,646,103...142,652,883

G

BPI fold containing family B, member 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BPIFB1 mRNA

NCBI chr 3:142,672,995...142,706,258
Ensembl chr 3:142,672,995...142,706,256

G

BRICHOS domain containing 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BRICD5 mRNA

NCBI chr10:13,498,726...13,500,259
Ensembl chr10:13,498,381...13,500,259

G

butyrophilin, subfamily 1, member A1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of BTN1A1 mRNA

NCBI chr17:41,653,499...41,664,246
Ensembl chr17:41,654,249...41,664,272

G

C1q and TNF related 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of C1QTNF2 mRNA

NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185

G

C1q and TNF related 7

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of C1QTNF7 mRNA

NCBI chr14:67,467,888...67,580,477
Ensembl chr14:67,468,014...67,580,410

G

complement C5a receptor 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of C5AR1 mRNA

NCBI chr 1:86,077,309...86,088,001

G

complement C5a receptor 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of C5AR2 mRNA

NCBI chr 1:76,930,381...76,945,432
Ensembl chr 1:76,930,383...76,959,517

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CAMK2N1 mRNA]

NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600

G

carbonic anhydrase 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CAR3 mRNA

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280

G

caspase recruitment domain family, member 10

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CARD10 mRNA]

NCBI chr 7:112,210,944...112,252,044
Ensembl chr 7:110,330,408...110,359,224

G

chromobox 4

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CBX4 mRNA]

NCBI chr10:104,835,685...104,841,727
Ensembl chr10:104,336,876...104,356,706

G

coiled-coil domain containing 42

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CCDC42 mRNA

NCBI chr10:53,289,956...53,300,135
Ensembl chr10:53,289,956...53,300,135

G

C-C motif chemokine ligand 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CCL2 mRNA

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 7

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

cyclin A1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CCNA1 mRNA; XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CCNA1 mRNA]

PMID:27935865 PMID:29891994

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin O

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CCNO mRNA

NCBI chr 2:44,630,873...44,633,912
Ensembl chr 2:44,626,369...44,633,914

G

CD177 molecule

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CD177 mRNA

NCBI chr 1:89,467,926...89,488,490
Ensembl chr 1:80,340,034...80,360,621

G

Cd5 molecule-like

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CD5L mRNA

NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753

G

cell division cycle 20B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CDC20B mRNA

NCBI chr 2:44,688,349...44,738,056

G

cadherin 26

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CDH26 mRNA

NCBI chr 3:185,898,185...185,950,892
Ensembl chr 3:165,520,439...165,572,149

G

cadherin-related family member 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CDHR1 mRNA

NCBI chr16:12,863,696...12,883,579
Ensembl chr16:12,843,437...12,863,396

G

cadherin, EGF LAG seven-pass G-type receptor 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CELSR3 mRNA

NCBI chr 8:118,409,136...118,438,593
Ensembl chr 8:109,530,641...109,558,354

G

complement factor D

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:9,813,150...9,815,053

G

chitinase 3 like 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CHI3L1 mRNA

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

chondrolectin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CHODL mRNA

NCBI chr11:17,654,137...17,676,450
Ensembl chr11:17,654,206...17,676,441

G

chordin-like 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CHRDL1 mRNA

NCBI chr X:106,889,125...106,992,937
Ensembl chr X:106,889,125...106,992,921

G

cholinergic receptor, muscarinic 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CHRM2 mRNA

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

G

carbohydrate sulfotransferase 6

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CHST5 mRNA

NCBI chr19:39,860,729...39,881,019
Ensembl chr19:39,860,501...39,881,064

G

cell death-inducing DFFA-like effector c

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CIDEC mRNA

NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:146,569,289...146,582,173

G

creatine kinase, mitochondrial 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CKMT2 mRNA

NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430

G

C-type lectin domain family 4, member D

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CLEC4D mRNA

NCBI chr 4:158,275,287...158,286,978
Ensembl chr 4:156,589,792...156,598,848

G

C-type lectin domain family 4, member E

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CLEC4E mRNA

NCBI chr 4:158,292,624...158,298,607
Ensembl chr 4:156,607,614...156,612,767

G

calponin 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CNN1 mRNA

NCBI chr 8:28,908,437...28,917,099
Ensembl chr 8:20,632,338...20,641,098

G

ciliary neurotrophic factor receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CNTFR mRNA

NCBI chr 5:61,619,326...61,657,359
Ensembl chr 5:56,823,965...56,841,392

G

collagen like tail subunit of asymmetric acetylcholinesterase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of COLQ mRNA

NCBI chr16:6,731,850...6,824,973
Ensembl chr16:6,731,858...6,787,107

G

cytochrome c oxidase subunit 7A1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of COX7A1 mRNA

NCBI chr 1:94,549,663...94,572,330
Ensembl chr 1:85,441,871...85,445,151

G

complexin 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CPLX1 mRNA

NCBI chr14:1,184,677...1,216,392

G

cAMP responsive element binding protein 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CREB1 mRNA]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 3-like 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CREB3L3 mRNA

NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048

G

cysteine-rich secretory protein 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CRISP3 mRNA

NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658

G

cysteine-rich secretory protein LCCL domain containing 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CRISPLD1 mRNA

NCBI chr 5:1,267,347...1,314,926
Ensembl chr 5:1,274,647...1,314,926

G

crystallin, lambda 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CRYL1 mRNA]

NCBI chr15:35,542,628...35,661,563
Ensembl chr15:31,427,054...31,545,997

G

colony stimulating factor 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CSF3 mRNA

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

colony stimulating factor 3 receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CSF3R mRNA

NCBI chr 5:143,583,126...143,604,382
Ensembl chr 5:138,301,506...138,317,881

G

cysteine and glycine-rich protein 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CSRP1 mRNA]

NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384

G

cathepsin C

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of CTSC mRNA]

NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:142,028,392...142,060,387

G

C-X-C motif chemokine ligand 12

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CXCL3 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CXCL5 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine receptor 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 4, subfamily f, polypeptide 18

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of CYP4F18 mRNA

NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,707,317...17,804,940

G

cystin 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of CYS1 mRNA

NCBI chr 6:41,300,836...41,318,071
Ensembl chr 6:41,300,836...41,318,071

G

DDB1 and CUL4 associated factor 12-like 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DCAF12L1 mRNA

NCBI chr X:123,695,286...123,698,905
Ensembl chr X:123,695,286...123,698,905

G

dachsous cadherin-related 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DCHS1 mRNA

NCBI chr 1:160,104,931...160,138,958
Ensembl chr 1:160,104,931...160,124,808

G

delta(4)-desaturase, sphingolipid 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of DEGS2 mRNA

NCBI chr 6:127,596,063...127,613,293
Ensembl chr 6:127,596,071...127,613,293

G

derlin 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DERL3 mRNA

NCBI chr20:12,753,926...12,766,478
Ensembl chr20:12,763,543...12,767,027

G

dihydrodiol dehydrogenase

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of DHDH mRNA]

NCBI chr 1:95,954,361...95,965,262
Ensembl chr 1:95,953,092...95,965,197

G

deleted in malignant brain tumors 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DMBT1 mRNA; XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of DMBT1 mRNA]

PMID:27935865 PMID:29891994

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

DMRT-like family A1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DMRTA1 mRNA

NCBI chr 5:104,415,893...104,422,433
Ensembl chr 5:104,415,893...104,422,433

G

dermatopontin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DPT mRNA

NCBI chr13:77,123,224...77,151,646
Ensembl chr13:77,123,115...77,151,639

G

dopamine receptor D1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of DRD1 mRNA

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002

G

endothelin 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EDN3 mRNA

NCBI chr 3:183,980,458...184,004,958
Ensembl chr 3:163,562,520...163,585,093

G

eukaryotic translation elongation factor 1 alpha 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of EEF1A2 mRNA]

NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071

G

epidermal growth factor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EGF mRNA

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

Eph receptor A3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA3 mRNA

NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900

G

EPH receptor A5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPHA5 mRNA

NCBI chr14:23,653,393...24,020,129
Ensembl chr14:23,653,393...24,017,317

G

epiphycan

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of EPYC mRNA

NCBI chr 7:32,436,620...32,474,326
Ensembl chr 7:32,436,620...32,474,135

G

F2R like trypsin receptor 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of F2RL1 mRNA]

NCBI chr 2:28,507,003...28,519,954
Ensembl chr 2:26,772,278...26,785,226

G

F2R like thrombin or trypsin receptor 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of F2RL3 mRNA

NCBI chr16:17,151,516...17,153,509
Ensembl chr16:17,117,441...17,119,472

G

coagulation factor III, tissue factor

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668

G

family with sequence similarity 13, member C

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FAM13C mRNA

NCBI chr20:18,065,625...18,187,792
Ensembl chr20:18,065,628...18,187,592

G

family with sequence similarity 240 member B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FAM240B mRNA

NCBI chr17:647,269...663,209
Ensembl chr17:657,303...663,206

G

FAT atypical cadherin 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of FAT2 mRNA]

NCBI chr10:39,364,072...39,456,324
Ensembl chr10:39,364,073...39,456,216

G

fibulin 7

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FBLN7 mRNA

NCBI chr 3:116,111,581...116,145,839
Ensembl chr 3:116,111,677...116,147,983

G

F-box protein 40

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FBXO40 mRNA

NCBI chr11:63,794,452...63,812,697
Ensembl chr11:63,794,624...63,812,697

G

Fc receptor-like 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FCRL2 mRNA

NCBI chr 2:172,694,308...172,707,261
Ensembl chr 2:172,694,308...172,707,051

G

formin homology 2 domain containing 3

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of FHOD3 mRNA]

NCBI chr18:15,993,079...16,425,796
Ensembl chr18:15,993,324...16,425,796

G

forkhead box N4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FOXN4 mRNA

NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921

G

formyl peptide receptor 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of FPR2 mRNA

NCBI chr 1:67,449,637...67,458,272
Ensembl chr 1:58,776,752...58,786,019

G

Fras1 related extracellular matrix 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FREM1 mRNA

NCBI chr 5:97,321,266...97,469,523
Ensembl chr 5:97,322,538...97,469,543

G

FERM and PDZ domain containing 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FRMPD4 mRNA

NCBI chr X:25,853,849...26,814,642
Ensembl chr X:25,853,934...26,814,637

G

frizzled-related protein

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FRZB mRNA

NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:65,332,277...65,365,208

G

gamma-aminobutyric acid type A receptor subunit alpha 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GABRA4 mRNA

NCBI chr14:36,944,747...37,021,652
Ensembl chr14:36,590,782...36,665,844

G

galactose-3-O-sulfotransferase 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of GAL3ST2 mRNA

NCBI chr 9:94,382,456...94,387,990
Ensembl chr 9:94,376,174...94,389,174

G

golgi associated kinase 1A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GASK1A mRNA

NCBI chr 8:130,488,279...130,521,242
Ensembl chr 8:121,610,787...121,642,942

G

glucosaminyl (N-acetyl) transferase 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of GCNT4 mRNA

NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082

G

growth differentiation factor 10

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GDF10 mRNA

NCBI chr16:9,237,182...9,250,537
Ensembl chr16:9,237,261...9,249,343

G

GDNF family receptor alpha 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GFRA3 mRNA

NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105

G

gap junction protein, alpha 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GJA3 mRNA

NCBI chr15:31,181,360...31,206,820
Ensembl chr15:31,181,369...31,206,810

G

G protein-coupled receptor associated sorting protein 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of GPRASP2 mRNA

NCBI chr X:98,817,668...98,823,814
Ensembl chr X:98,817,593...98,824,402

G

glutathione S-transferase kappa 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of GSTK1 mRNA]

NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase zeta 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of GSTZ1 mRNA]

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:106,794,074...106,805,284

G

hes family bHLH transcription factor 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of HES1 mRNA]

NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192

G

Hedgehog-interacting protein

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of HHIP mRNA

NCBI chr19:44,768,038...44,856,878
Ensembl chr19:27,863,213...27,952,528

G

hydroxysteroid (17-beta) dehydrogenase 8

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of HSD17B8 mRNA]

NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742

G

5-hydroxytryptamine receptor 2B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of HTR2B mRNA

NCBI chr 9:94,184,442...94,206,851
Ensembl chr 9:86,742,102...86,755,108

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of IDH2 mRNA]

NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025

G

indoleamine 2,3-dioxygenase 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon, alpha-inducible protein 27 like 2A

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of IFI27L2 mRNA]

NCBI chr 6:122,598,872...122,600,358
Ensembl chr 6:122,598,872...122,600,360

G

interleukin 19

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of IL19 mRNA

NCBI chr13:44,949,989...44,958,714
Ensembl chr13:42,399,138...42,405,473

G

interleukin 1 beta

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

indolethylamine N-methyltransferase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of INMT mRNA

NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493

G

interferon regulatory factor 7

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of IRF7 mRNA]

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

insulin receptor substrate 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of IRS2 mRNA]

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482

G

ISG15 ubiquitin-like modifier

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ISG15 mRNA]

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ITPR1 mRNA]

NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:141,187,418...141,510,491

G

inositol 1,4,5-trisphosphate receptor, type 3

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ITPR3 mRNA]

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

joining chain of multimeric IgA and IgM

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of JCHAIN mRNA

NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,538,952...19,546,298

G

KN motif and ankyrin repeat domains 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KANK4 mRNA

NCBI chr 5:113,401,491...113,465,526
Ensembl chr 5:113,402,468...113,465,555

G

kelch repeat and BTB domain containing 12

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KBTBD12 mRNA

NCBI chr 4:121,014,636...121,088,701
Ensembl chr 4:121,016,257...121,088,443

G

potassium voltage-gated channel subfamily A member 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KCNA1 mRNA

NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682

G

potassium calcium-activated channel subfamily M alpha 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KCNMA1 mRNA

NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198

G

kelch-like family member 13

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KLHL13 mRNA

NCBI chr X:113,942,309...114,107,299
Ensembl chr X:113,942,309...114,107,321

G

kelch-like family member 33

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KLHL33 mRNA

NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438

G

kelch-like family member 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of KLHL4 mRNA

NCBI chr X:79,429,193...79,719,482
Ensembl chr X:79,622,113...79,719,480

G

kallikrein related-peptidase 6

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KLK6 mRNA

NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121

G

kininogen 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KNG2 mRNA

NCBI chr11:91,418,470...91,440,841
Ensembl chr11:77,909,612...78,002,971

G

keratin 16

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KRT16 mRNA

NCBI chr10:85,168,357...85,171,816
Ensembl chr10:85,066,802...85,171,799

G

keratin 84

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of KRT84 mRNA

NCBI chr 7:132,649,064...132,656,885
Ensembl chr 7:132,649,061...132,656,874

G

LETM1 domain containing 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of LETMD1 mRNA]

NCBI chr 7:133,461,920...133,476,592
Ensembl chr 7:131,584,259...131,597,796

G

lin-28 homolog A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LIN28A mRNA

NCBI chr 5:151,510,891...151,527,884
Ensembl chr 5:146,227,119...146,244,122

G

lipase F, gastric type

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of LIPF mRNA

NCBI chr 1:231,493,498...231,511,845
Ensembl chr 1:231,493,498...231,511,845

G

lipase, family member N

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LIPN mRNA

NCBI chr 1:231,584,950...231,603,456
Ensembl chr 1:231,584,956...231,603,468

G

lectin, mannose-binding, 1 like

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of LMAN1L mRNA

NCBI chr 8:58,010,839...58,029,599
Ensembl chr 8:58,010,839...58,023,681

G

lamin tail domain containing 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LMNTD1 mRNA

NCBI chr 4:178,354,302...178,588,483
Ensembl chr 4:178,354,137...178,588,477

G

LIM domain only 4

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of LMO4 mRNA]

NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880

G

leiomodin 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of LMOD3 mRNA

NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244

G

leucine-rich alpha-2-glycoprotein 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LRG1 mRNA

NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813

G

leucine rich repeat containing 3B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of LRRC3B mRNA

NCBI chr15:9,973,580...10,050,891
Ensembl chr15:9,969,983...10,051,066

G

leucine rich repeat containing 4B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of LRRC4B mRNA

NCBI chr 1:94,922,034...94,956,309
Ensembl chr 1:94,935,603...94,956,263

G

MEF2 activating motif and SAP domain containing transcriptional regulator

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MAMSTR mRNA

NCBI chr 1:96,109,715...96,116,295
Ensembl chr 1:96,110,343...96,115,744

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of MAP1LC3A mRNA]

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

multiciliate differentiation and DNA synthesis associated cell cycle protein

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MCIDAS mRNA

NCBI chr 2:44,636,820...44,644,551
Ensembl chr 2:44,636,856...44,642,601

G

microfibril associated protein 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MFAP4 mRNA

NCBI chr10:46,167,158...46,170,176
Ensembl chr10:46,167,217...46,170,155

G

maltase-glucoamylase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MGAM mRNA

NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715

G

membrane metallo-endopeptidase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MME mRNA

NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 10

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

matrix metallopeptidase 8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MMP8 mRNA

NCBI chr 8:4,724,009...4,733,864
Ensembl chr 8:4,724,029...4,733,520

G

myostatin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MSTN mRNA

NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933

G

msh homeobox 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MSX3 mRNA

NCBI chr 1:194,839,041...194,842,209
Ensembl chr 1:194,839,041...194,841,969

G

muscle associated receptor tyrosine kinase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MUSK mRNA

NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932

G

myeloid-associated differentiation marker-like 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MYADML2 mRNA

NCBI chr10:105,922,557...105,927,867
Ensembl chr10:105,925,947...105,927,575

G

myosin heavy chain 13

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MYH13 mRNA

NCBI chr10:52,012,779...52,068,960
Ensembl chr10:52,009,425...52,068,951

G

myocilin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MYOC mRNA

NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127

G

myocardin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MYOCD mRNA

NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627

G

myogenin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MYOG mRNA

NCBI chr13:48,297,476...48,300,065
Ensembl chr13:45,745,436...45,748,039

G

myozenin 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MYOZ3 mRNA

NCBI chr18:54,026,133...54,046,151
Ensembl chr18:54,026,152...54,102,126

G

N-acetylglutamate synthase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of NAGS mRNA

NCBI chr10:87,098,330...87,102,465
Ensembl chr10:87,098,330...87,102,465

G

neural EGFL like 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of NELL2 mRNA

NCBI chr 7:126,343,089...126,662,903
Ensembl chr 7:126,198,851...126,733,503

G

nuclear factor, erythroid 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NFE2 mRNA

NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108

G

NK2 homeobox 8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NKX2-9 mRNA

NCBI chr 6:74,086,274...74,087,977
Ensembl chr 6:74,086,274...74,087,977

G

NK3 homeobox 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of NKX3-1 mRNA

NCBI chr15:50,883,661...50,886,253
Ensembl chr15:44,473,851...44,476,441

G

NLR family, pyrin domain containing 12

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP12 mRNA

NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811

G

neuropeptide Y

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of NPY mRNA

NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495

G

neurotrophin 3

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of NTF3 mRNA]

NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596

G

olfactomedin-like 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of OLFML1 mRNA

NCBI chr 1:161,478,129...161,502,541
Ensembl chr 1:161,478,242...161,502,537

G

opioid binding protein/cell adhesion molecule-like

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of OPCML mRNA

NCBI chr 8:34,451,629...35,562,897
Ensembl chr 8:26,192,841...27,300,620

G

otopetrin 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of OTOP2 mRNA

NCBI chr10:100,564,727...100,574,298
Ensembl chr10:100,564,727...100,574,298

G

purinergic receptor P2X 4

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of P2RX4 mRNA]

NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253

G

paired box 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PAX1 mRNA

NCBI chr 3:155,244,961...155,254,836
Ensembl chr 3:134,789,182...134,801,636

G

paired box 7

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PAX7 mRNA

NCBI chr 5:157,279,623...157,381,188
Ensembl chr 5:151,999,092...152,097,979

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PCK1 mRNA

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PCK2 mRNA]

NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283

G

phosphodiesterase 3A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PDE3A mRNA

NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:174,172,868...174,438,274

G

PPARGC1 and ESRR induced regulator, muscle 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PERM1 mRNA

NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323

G

phosphoglucomutase 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PGM5 mRNA

NCBI chr 1:222,325,638...222,513,434
Ensembl chr 1:222,325,643...222,513,437

G

progesterone receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PGR mRNA

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344

G

phosphate regulating endopeptidase X-linked

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PHEX mRNA

NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469

G

paired-Ig-like receptor A2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of LILRA6 mRNA

NCBI chr 1:65,352,125...65,422,842
Ensembl chr 1:65,415,946...65,422,853

G

paired-like homeodomain 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PITX2 mRNA

NCBI chr 2:220,391,417...220,411,588
Ensembl chr 2:217,717,693...217,737,293

G

PKHD1 like 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PKHD1L1 mRNA

NCBI chr 7:75,620,384...75,795,335
Ensembl chr 7:75,620,484...75,795,335

G

protein kinase N1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PKN1 mRNA]

NCBI chr19:24,442,130...24,470,107
Ensembl chr19:24,442,122...24,470,107

G

phospholipase C, beta 4

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PLCB4 mRNA]

NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392

G

perilipin 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PLIN1 mRNA

NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:133,664,892...133,676,828

G

RNA polymerase I subunit H

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of POLR1H mRNA]

NCBI chr20:1,594,936...1,598,854
Ensembl chr20:1,594,936...1,598,854

G

pro-platelet basic protein

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of PPBP mRNA

NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130

G

proline-rich acidic protein 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of PRAP1 mRNA

NCBI chr 1:204,312,723...204,316,519
Ensembl chr 1:194,883,078...194,886,872

G

PR/SET domain 6

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PRDM6 mRNA

NCBI chr18:46,904,115...47,008,482
Ensembl chr18:46,904,127...47,007,823

G

prokineticin 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of PROK2 mRNA

NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385

G

proline rich 32

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PRR32 mRNA

NCBI chr X:123,978,010...123,979,928
Ensembl chr X:123,977,985...123,979,942

G

psoriasis susceptibility 1 candidate 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of PSORS1C2 mRNA

NCBI chr20:3,202,178...3,203,599
Ensembl chr20:3,202,174...3,203,599

G

prostaglandin D2 receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PTGDR mRNA

NCBI chr15:17,360,304...17,367,679
Ensembl chr15:17,360,304...17,367,679

G

prostaglandin F receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PTGFR mRNA

NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650

G

PWWP domain containing 2B

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PWWP2B mRNA]

NCBI chr 1:194,040,395...194,059,979
Ensembl chr 1:194,041,341...194,059,958

G

peroxisomal membrane protein 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PXMP2 mRNA]

NCBI chr12:46,394,051...46,404,561
Ensembl chr12:46,394,193...46,404,557

G

pyrroline-5-carboxylate reductase 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PYCR1 mRNA; XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of PYCR1 mRNA]

PMID:27935865 PMID:29891994

NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549

G

RAB17, member RAS oncogene family

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of RAB17 mRNA]

NCBI chr 9:91,552,924...91,566,759
Ensembl chr 9:91,553,464...91,566,451

G

RAB2B, member RAS oncogene family

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of RAB2B mRNA]

NCBI chr15:24,968,364...24,988,990
Ensembl chr15:24,968,803...24,989,113

G

Rap1 GTPase-activating protein

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of RAP1GAP mRNA]

NCBI chr 5:149,873,987...149,939,254
Ensembl chr 5:149,892,019...149,939,253

G

RASD family, member 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RASD2 mRNA

NCBI chr19:13,594,291...13,605,016
Ensembl chr19:13,594,291...13,605,016

G

regulator of calcineurin 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RCAN2 mRNA

NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856

G

RAD52 motif containing 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of RDM1 mRNA]

NCBI chr10:86,562,871...86,573,034
Ensembl chr10:86,539,553...86,573,034

G

resistin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RETN mRNA

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:1,710,881...1,712,620

G

ripply transcriptional repressor 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RIPPLY1 mRNA

NCBI chr X:103,436,731...103,440,904
Ensembl chr X:103,436,729...103,443,349

G

roundabout guidance receptor 4

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ROBO4 mRNA

NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519

G

RAS related

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of RRAS mRNA]

NCBI chr 1:104,637,061...104,640,841
Ensembl chr 1:95,500,566...95,504,357

G

retrotransposon Gag like 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RTL3 mRNA

NCBI chr X:71,947,343...71,951,008
Ensembl chr X:71,948,253...71,950,121

G

retrotransposon Gag like 8A

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of RTL8A mRNA]

NCBI chr X:133,414,027...133,415,240
Ensembl chr X:133,414,030...133,415,240

G

RUNX1 partner transcriptional co-repressor 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of RUNX1T1 mRNA

NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592

G

S100 calcium binding protein A8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

SAM domain, SH3 domain and nuclear localization signals, 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SAMSN1 mRNA

NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900

G

SH3 domain binding kinase family, member 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SBK2 mRNA

NCBI chr 1:68,874,081...68,881,918
Ensembl chr 1:68,874,152...68,881,916

G

secretogranin III

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SCG3 mRNA

NCBI chr 8:76,399,777...76,442,015
Ensembl chr 8:76,399,777...76,442,015

G

selectin L

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SELL mRNA

NCBI chr13:78,950,100...78,969,604
Ensembl chr13:76,416,915...76,436,456

G

selectin P

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SELP mRNA

NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845

G

secreted frizzled-related protein 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of SFRP1 mRNA]

NCBI chr16:75,278,325...75,316,736
Ensembl chr16:68,575,763...68,614,286

G

SH2 domain containing 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SH2D5 mRNA

NCBI chr 5:150,469,738...150,480,615
Ensembl chr 5:150,467,728...150,479,955

G

shisa family member 8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SHISA8 mRNA

NCBI chr 7:113,722,408...113,727,858
Ensembl chr 7:113,722,408...113,727,858

G

SHOX homeobox 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SHOX2 mRNA

NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143

G

solute carrier family 12, member 8

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC12A8 mRNA

NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834

G

solute carrier family 1 member 3

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of SLC1A3 mRNA]

NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 1 member 5

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of SLC1A5 mRNA]

NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 25, member 34

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC25A34 mRNA

NCBI chr 5:153,932,081...153,936,854

G

solute carrier family 26 member 7

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC26A7 mRNA

NCBI chr 5:27,884,400...28,021,865
Ensembl chr 5:27,887,042...28,021,658

G

solute carrier family 2 member 13

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC2A13 mRNA

NCBI chr 7:122,399,329...122,726,605
Ensembl chr 7:122,399,330...122,726,605

G

solute carrier family 2 member 3

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SLC2A3 mRNA

NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 38, member 11

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SLC38A11 mRNA

NCBI chr 3:70,374,550...70,442,313
Ensembl chr 3:49,987,124...50,033,615

G

solute carrier family 38, member 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC38A5 mRNA

NCBI chr X:16,885,701...16,894,470
Ensembl chr X:14,213,729...14,222,498

G

solute carrier family 5 member 7

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLC5A7 mRNA

NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258

G

solute carrier family 6 member 12

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SLC6A12 mRNA

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

sarcolipin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SLN mRNA

NCBI chr 8:54,221,389...54,248,110
Ensembl chr 8:54,243,542...54,247,791

G

syntaphilin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SNPH mRNA

NCBI chr 3:140,098,540...140,139,342
Ensembl chr 3:140,099,708...140,139,453

G

sortilin-related VPS10 domain containing receptor 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SORCS1 mRNA

NCBI chr 1:249,080,662...249,594,520
Ensembl chr 1:249,081,355...249,594,507

G

SRY-box transcription factor 10

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SOX10 mRNA

NCBI chr 7:112,605,721...112,615,097
Ensembl chr 7:110,725,274...110,735,544

G

SRY-box transcription factor 9

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of SOX9 mRNA]

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

spermatogenesis associated, serine-rich 2-like

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of SPATS2L mRNA]

NCBI chr 9:59,319,949...59,493,864
Ensembl chr 9:59,320,276...59,493,967

G

spondin 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

small proline-rich protein 1B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SPRR1B mRNA

NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567

G

small proline rich protein 2A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SPRR2H mRNA

NCBI chr 2:177,815,964...177,816,236
Ensembl chr 2:177,815,964...177,816,236

G

small proline rich protein 2B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SPRR2B mRNA

NCBI chr 2:177,852,824...177,853,096
Ensembl chr 2:177,852,824...177,853,096

G

small proline-rich protein 2D

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SPRR2D mRNA

NCBI chr 2:177,870,082...177,870,679
Ensembl chr 2:177,870,434...177,870,679

G

small proline rich protein 2F

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SPRR2F mRNA

NCBI chr 2:177,989,974...177,990,204
Ensembl chr 2:177,989,974...177,990,204

G

serglycin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of SRGN mRNA

NCBI chr20:30,442,810...30,479,549
Ensembl chr20:30,442,813...30,457,406

G

sushi-repeat-containing protein, X-linked

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SRPX mRNA

NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882

G

ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ST6GALNAC2 mRNA]

NCBI chr10:101,910,220...101,928,412
Ensembl chr10:101,909,971...101,915,008
Ensembl chr10:101,909,971...101,915,008

G

StAR-related lipid transfer domain containing 10

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of STARD10 mRNA]

NCBI chr 1:155,722,637...155,748,007
Ensembl chr 1:155,718,389...155,747,094

G

stanniocalcin 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of STC2 mRNA]

NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973

G

syntaxin binding protein 5L

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of STXBP5L mRNA

NCBI chr11:63,334,667...63,654,270
Ensembl chr11:63,334,667...63,657,014

G

sushi domain containing 5

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SUSD5 mRNA

NCBI chr 8:113,996,771...114,036,133
Ensembl chr 8:113,997,362...114,035,861

G

SVOP like

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of SVOPL mRNA

NCBI chr 4:66,697,550...66,751,699
Ensembl chr 4:66,698,177...66,758,978

G

transgelin

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TAGLN mRNA; XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TAGLN mRNA]

PMID:27935865 PMID:29891994

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

T cell-interacting, activating receptor on myeloid cells 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TARM1 mRNA

NCBI chr 1:65,666,742...65,682,402
Ensembl chr 1:65,671,902...65,679,626

G

TBC1 domain family, member 16

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TBC1D16 mRNA]

NCBI chr10:104,400,963...104,486,698
Ensembl chr10:104,402,398...104,486,670

G

T-box transcription factor 15

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TBX15 mRNA

NCBI chr 2:186,576,650...186,687,748
Ensembl chr 2:186,576,676...186,687,663

G

thromboxane A2 receptor

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TBXA2R mRNA

NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176

G

tryptophan 2,3-dioxygenase

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TDO2 mRNA

NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511

G

trefoil factor 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TFF2 mRNA

NCBI chr20:9,215,750...9,219,619
Ensembl chr20:9,215,761...9,219,619

G

transglutaminase 2

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TGM2 mRNA]

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

thyroid hormone responsive

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of THRSP mRNA

NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075

G

TIMP metallopeptidase inhibitor 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TIMP1 mRNA

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

transmembrane protein 132C

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM132C mRNA

NCBI chr12:29,115,213...29,437,900
Ensembl chr12:29,116,467...29,437,870

G

transmembrane protein 182

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM182 mRNA

NCBI chr 9:43,059,432...43,111,318
Ensembl chr 9:43,059,439...43,111,317

G

transmembrane protein 252

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TMEM252 mRNA

NCBI chr 1:222,316,982...222,321,946
Ensembl chr 1:222,316,795...222,321,943

G

transmembrane protein 255A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TMEM255A mRNA

NCBI chr X:116,970,793...117,035,008
Ensembl chr X:116,970,695...117,035,008

G

transmembrane protein 30B

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TMEM30B mRNA]

NCBI chr 6:97,987,471...97,990,546
Ensembl chr 6:92,249,790...92,254,842

G

tenascin C

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TNC mRNA]

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

TNF receptor superfamily member 14

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TNFRSF14 mRNA]

NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703

G

TNF superfamily member 14

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TNFSF14 mRNA

NCBI chr 9:2,068,295...2,073,128
Ensembl chr 9:2,069,104...2,073,216

G

TNF superfamily member 9

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TNFSF9 mRNA

NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:1,944,017...1,946,345

G

troponin I2, fast skeletal type

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TNNI2 mRNA]

NCBI chr 1:197,595,012...197,597,554
Ensembl chr 1:197,594,813...197,597,560

G

troponin T1, slow skeletal type

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TNNT1 mRNA

NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721

G

TPD52 like 1

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TPD52L1 mRNA]

NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109

G

trafficking regulator of GLUT4 (SLC2A4) 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TRARG1 mRNA

NCBI chr10:61,521,107...61,541,494
Ensembl chr10:61,521,107...61,541,494

G

triggering receptor expressed on myeloid cells 1

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TREM1 mRNA

NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203

G

TLR4 interactor with leucine-rich repeats

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TRIL mRNA

NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172

G

thiosulfate sulfurtransferase

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of TST mRNA]

NCBI chr 7:111,828,557...111,836,980
Ensembl chr 7:109,948,062...109,957,216

G

tubulin, beta 3 class III

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of TUBB3 mRNA

NCBI chr19:68,365,687...68,374,741
Ensembl chr19:51,457,184...51,466,243

G

twist family bHLH transcription factor 2

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TWIST2 mRNA

NCBI chr 9:99,822,242...99,866,722
Ensembl chr 9:92,374,574...92,419,222

G

taxilin beta

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of TXLNB mRNA

NCBI chr 1:12,404,845...12,449,977
Ensembl chr 1:12,404,859...12,449,975

G

uroplakin 3A

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of UPK3A mRNA

NCBI chr 7:116,128,981...116,139,950
Ensembl chr 7:116,134,874...116,139,948

G

WAP four-disulfide core domain 17

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of WFDC17 mRNA

NCBI chr10:68,561,954...68,562,801
Ensembl chr10:68,561,954...68,562,801

G

Wnt family member 2B

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of WNT2B mRNA

NCBI chr 2:195,142,573...195,156,945
Ensembl chr 2:192,453,824...192,470,308

G

zinc finger protein 366

multiple interactions

ISO

[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of ZFP366 mRNA

NCBI chr 2:30,578,552...30,640,546
Ensembl chr 2:30,578,715...30,642,182

G

zinc finger protein 524

multiple interactions

ISO

XL147 inhibits the reaction [N-nitroso-tris-chloroethylurea results in increased expression of ZNF524 mRNA]

NCBI chr 1:68,824,803...68,828,363
Ensembl chr 1:68,824,803...68,828,594

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 5 family, member A1

increases response to substance

ISO

ALDH5A1 gene mutant form results in increased susceptibility to XL765

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

mechanistic target of rapamycin kinase

decreases activity

ISO

XL765 results in decreased activity of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20856
role	20816
biological role	20814
biochemical role	20261
enzyme inhibitor	19245
EC 2.* (transferase) inhibitor	15088
EC 2.7.* (P-containing group transferase) inhibitor	14456
lipid kinase inhibitor	1033
EC 2.7.1.1 (hexokinase) inhibitor +	250
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor +	880

paths to the root