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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cardiotoxic agent
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Accession:CHEBI:50912 term browser browse the term
Definition:A role played by a chemical compound exihibiting itself through the ability to induce damage to the heart and cardiomyocytes.
Synonyms:related_synonym: cardiotoxicant


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T-2 toxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 increases expression EXP T-2 Toxin results in increased expression of ATF4 protein CTD PMID:34637808 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression		 EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP T-2 Toxin results in increased expression of DDIT3 protein CTD PMID:34637808 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation EXP T-2 Toxin results in increased phosphorylation of EIF2AK3 protein CTD PMID:34637808 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP T-2 Toxin results in increased phosphorylation of EIF2S1 protein CTD PMID:34637808 NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases expression EXP T-2 Toxin results in decreased expression of HSPA5 protein CTD PMID:34637808 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
tilmicosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      biological role 5016
        aetiopathogenetic role 4604
          cardiotoxic agent 7
            (13R)-13-dihydrocarminomycin 0
            4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid 0
            T-2 toxin 6
            acid red 26 0
            doxorubicinol 0
            fluoroacetaldehyde 0
            nogalamycin 0
            pavettamine 0
            taxine B 0
            tilmicosin 1
paths to the root