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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:teratogenic agent
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Accession:CHEBI:50905 term browser browse the term
Definition:A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect.
Synonyms:related_synonym: agent teratogene;   teratogen;   teratogeno

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(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295 		JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,402...41,972,301 		JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion		 EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein		 CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,596,235...120,627,806
Ensembl chr 1:120,367,667...120,695,899 		JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683 		JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion		 EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein		 CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405 		JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795 		JBrowse link
G LAMB1 laminin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of LAMB1 mRNA CTD PMID:32423882 NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
decreases expression		 EXP Nicotine results in decreased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 mRNA		 CTD PMID:32423882 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
decreases expression		 EXP Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA		 CTD PMID:32423882 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases phosphorylation
decreases expression		 EXP Nicotine results in decreased phosphorylation of MAPK8 protein
Nicotine results in decreased expression of MAPK8 mRNA		 CTD PMID:32423882 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Nicotine results in increased expression of MMP9 mRNA CTD PMID:32423882 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264 		JBrowse link
G OCLN occludin decreases expression EXP Nicotine results in decreased expression of OCLN mRNA CTD PMID:32423882 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033 		JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 decreases expression EXP Nicotine results in decreased expression of RPP38 mRNA CTD PMID:32423882 NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,195...46,725,920 		JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904 		JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884 		JBrowse link
arotinoid acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP4 fatty acid binding protein 4, adipocyte decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of FABP4 mRNA CTD PMID:15583048 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases activity EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased activity of GPD1 protein CTD PMID:15583048 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825 		JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 increases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of NR2F1 mRNA CTD PMID:15583048 NCBI chr 2:100,447,661...100,457,510
Ensembl chr 2:100,447,847...100,457,904 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of PPARG mRNA CTD PMID:15583048 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947 		JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of RXRA mRNA CTD PMID:15583048 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,503...273,797,622 		JBrowse link
G SREBP-1 sterol regulatory element binding protein 1 decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of SREBP-1 mRNA CTD PMID:15583048
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP benazepril results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376 		JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 increases expression EXP Clofibrate results in increased expression of ACO1 mRNA CTD PMID:17363680 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Clofibrate results in increased expression of ACOX1 mRNA CTD PMID:16896063 PMID:17437637 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,428,360...5,479,544 		JBrowse link
G AGT angiotensinogen multiple interactions EXP Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428 		JBrowse link
G ALB albumin decreases expression EXP Clofibrate results in decreased expression of ALB mRNA CTD PMID:16896063 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Clofibrate results in increased expression of BAX mRNA CTD PMID:17437637 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Clofibrate results in decreased expression of BCL2L1 mRNA CTD PMID:17437637 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359 		JBrowse link
G CAT catalase increases expression EXP Clofibrate results in increased expression of CAT mRNA CTD PMID:17437637 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Clofibrate results in increased expression of CPT1A mRNA CTD PMID:16896063 PMID:17363680 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,984 		JBrowse link
G CTSB cathepsin B increases expression EXP Clofibrate results in increased expression of CTSB mRNA CTD PMID:16896063 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737 		JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression EXP Clofibrate results in decreased expression of DIO2 mRNA CTD PMID:16896063 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,425...103,323,258 		JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions		 EXP Clofibrate results in decreased expression of EDN1 protein
Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]		 CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clofibrate results in increased expression of FABP1 mRNA CTD PMID:17363680 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,964 		JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Clofibrate results in decreased expression of GPX1 mRNA CTD PMID:17437637 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clofibrate results in increased expression of JUN mRNA CTD PMID:17437637 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376 		JBrowse link
G LOC110260333 hydroxymethylglutaryl-CoA synthase, mitochondrial-like increases expression EXP Clofibrate results in increased expression of HMGCS2 mRNA CTD PMID:17363680 NCBI chr 4:101,385,486...101,404,273
Ensembl chr 4:101,385,512...101,443,405 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Clofibrate results in increased expression of MYC mRNA CTD PMID:17437637 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions		 EXP Clofibrate results in increased expression of NOS3 protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein]		 CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions		 EXP Clofibrate results in increased expression of PPARA; Clofibrate results in increased expression of PPARA protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]		 CTD PMID:17105827 PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361 		JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clofibrate results in increased expression of SCD mRNA CTD PMID:17363680 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,560...111,478,031 		JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression EXP Clofibrate results in increased expression of SLC5A5 mRNA CTD PMID:16896063 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,154...59,885,265 		JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Clofibrate results in increased expression of SOD1 mRNA CTD PMID:17437637 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749 		JBrowse link
G THRA thyroid hormone receptor alpha decreases expression EXP Clofibrate results in decreased expression of THRA mRNA CTD PMID:16896063 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618 		JBrowse link
G TNF tumor necrosis factor decreases expression EXP Clofibrate results in decreased expression of TNF mRNA CTD PMID:17437637 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655 		JBrowse link
G TPO thyroid peroxidase increases expression EXP Clofibrate results in increased expression of TPO mRNA CTD PMID:16896063 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943 		JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression EXP Clofibrate results in increased expression of TSHR mRNA CTD PMID:16896063 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922 		JBrowse link
G TTR transthyretin decreases expression EXP Clofibrate results in decreased expression of TTR mRNA CTD PMID:16896063 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,193...115,503,977 		JBrowse link
diethyl maleate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRDX2 peroxiredoxin 2 decreases activity EXP diethyl maleate results in decreased activity of PRDX2 protein CTD PMID:19208552 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,796...66,213,567 		JBrowse link
ethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADL acyl-CoA dehydrogenase long chain increases expression EXP Ethanol results in increased expression of ACADL mRNA CTD PMID:28069986 NCBI chr15:112,935,631...112,969,381
Ensembl chr15:112,933,498...112,969,578 		JBrowse link
G ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif 8 increases expression EXP Ethanol results in increased expression of ADAMTS8 mRNA CTD PMID:28069986 NCBI chr 9:57,090,313...57,113,077
Ensembl chr 9:57,090,615...57,110,476 		JBrowse link
G AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 decreases expression EXP Ethanol results in decreased expression of AGPAT1 mRNA CTD PMID:28069986 NCBI chr 7:24,205,930...24,208,430
Ensembl chr 7:24,204,902...24,213,193 		JBrowse link
G AGPS alkylglycerone phosphate synthase decreases expression EXP Ethanol results in decreased expression of AGPS mRNA CTD PMID:28069986 NCBI chr15:83,146,063...83,285,905
Ensembl chr15:83,145,573...83,391,970 		JBrowse link
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 increases expression EXP Ethanol results in increased expression of ALDH9A1 mRNA CTD PMID:28069986 NCBI chr 4:85,029,914...85,057,650 JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases expression EXP Ethanol results in increased expression of ALOX5 mRNA CTD PMID:28069986 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,858,975...90,907,094 		JBrowse link
G APP amyloid beta precursor protein increases expression EXP Ethanol results in increased expression of APP mRNA CTD PMID:28069986 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057 		JBrowse link
G ARSK arylsulfatase family member K increases expression EXP Ethanol results in increased expression of ARSK mRNA CTD PMID:28069986 NCBI chr 2:102,164,089...102,210,293
Ensembl chr 2:102,164,178...102,212,780 		JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 increases expression EXP Ethanol results in increased expression of ATP6V0D2 mRNA CTD PMID:28069986 NCBI chr 4:50,694,188...50,749,373
Ensembl chr 4:50,694,189...50,749,378 		JBrowse link
G C5H12orf57 chromosome 5 C12orf57 homolog increases expression EXP Ethanol results in increased expression of C12ORF57 mRNA CTD PMID:28069986 NCBI chr 5:63,779,510...63,781,307
Ensembl chr 5:63,779,511...63,781,308 		JBrowse link
G CBS cystathionine beta-synthase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein CTD PMID:16792574 NCBI chr13:206,205,942...206,231,363 JBrowse link
G CCNB1IP1 cyclin B1 interacting protein 1 decreases expression EXP Ethanol results in decreased expression of CCNB1IP1 mRNA CTD PMID:28069986 NCBI chr 7:78,553,680...78,576,057
Ensembl chr 7:78,553,764...78,575,516 		JBrowse link
G CD109 CD109 molecule increases expression EXP Ethanol results in increased expression of CD109 mRNA CTD PMID:28069986 NCBI chr 1:92,081,675...92,241,079
Ensembl chr 1:92,048,461...92,286,747 		JBrowse link
G CD47 CD47 molecule increases expression EXP Ethanol results in increased expression of CD47 mRNA CTD PMID:28069986 NCBI chr13:151,427,933...151,488,064
Ensembl chr13:151,429,288...151,502,164 		JBrowse link
G CLDN4 claudin 4 decreases expression EXP Ethanol results in decreased expression of CLDN4 mRNA CTD PMID:28069986 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925 		JBrowse link
G CLU clusterin increases expression EXP Ethanol results in increased expression of CLU mRNA CTD PMID:28069986 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,590...11,352,475 		JBrowse link
G CTH cystathionine gamma-lyase increases activity
multiple interactions		 EXP Ethanol results in increased activity of CTH protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein		 CTD PMID:16792574 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,435,690...142,486,367 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 increases expression EXP Ethanol results in increased expression of CYP51 mRNA CTD PMID:28069986 NCBI chr 9:72,057,506...72,079,587
Ensembl chr 9:72,057,511...72,079,444 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 decreases expression EXP Ethanol results in decreased expression of EEF2 mRNA CTD PMID:28069986 NCBI chr 2:74,746,541...74,756,687
Ensembl chr 2:74,747,080...74,756,680 		JBrowse link
G EIF3L eukaryotic translation initiation factor 3 subunit L decreases expression EXP Ethanol results in decreased expression of EIF3L mRNA CTD PMID:28069986 NCBI chr 5:9,970,013...9,996,086
Ensembl chr 5:9,968,428...9,996,316 		JBrowse link
G FBLN2 fibulin 2 increases expression EXP Ethanol results in increased expression of FBLN2 mRNA CTD PMID:28069986 NCBI chr13:70,757,255...70,830,430
Ensembl chr13:70,757,265...70,830,388 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A decreases expression EXP Ethanol results in decreased expression of FKBP1A mRNA CTD PMID:28069986 NCBI chr17:33,910,047...33,935,212 JBrowse link
G FUCA1 alpha-L-fucosidase 1 increases expression EXP Ethanol results in increased expression of FUCA1 mRNA CTD PMID:28069986 NCBI chr 6:81,638,213...81,655,993
Ensembl chr 6:81,637,989...81,723,231 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 increases expression EXP Ethanol results in increased expression of GABRB3 mRNA CTD PMID:28069986 NCBI chr 1:140,566,443...140,906,516
Ensembl chr 1:140,566,287...140,905,658 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
multiple interactions		 EXP Ethanol results in increased expression of GCLC mRNA
Ethanol results in increased activity of GCLC protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA		 CTD PMID:16792574 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535 		JBrowse link
G GPX6 glutathione peroxidase 6 increases expression EXP Ethanol results in increased expression of GPX6 mRNA CTD PMID:28069986 NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992 		JBrowse link
G GRTP1 growth hormone regulated TBC protein 1 decreases expression EXP Ethanol results in decreased expression of GRTP1 mRNA CTD PMID:28069986 NCBI chr11:78,618,720...78,637,502
Ensembl chr11:78,618,702...78,637,472 		JBrowse link
G GSR glutathione-disulfide reductase increases activity
increases expression
multiple interactions		 EXP Ethanol results in increased activity of GSR protein
Ethanol results in increased expression of GSR mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA		 CTD PMID:16792574 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989 		JBrowse link
G GSS glutathione synthetase increases expression
increases activity
multiple interactions		 EXP Ethanol results in increased expression of GSS mRNA
Ethanol results in increased activity of GSS protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA		 CTD PMID:16792574 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,304 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 increases expression
multiple interactions		 EXP Ethanol results in increased expression of GSTA1 mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA		 CTD PMID:16792574 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728 		JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 increases expression EXP Ethanol results in increased expression of HSD17B1 mRNA CTD PMID:28069986 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569 		JBrowse link
G HSD17B14 hydroxysteroid 17-beta dehydrogenase 14 decreases expression EXP Ethanol results in decreased expression of HSD17B14 mRNA CTD PMID:28069986 NCBI chr 6:54,125,229...54,144,143 JBrowse link
G HTRA1 HtrA serine peptidase 1 increases expression EXP Ethanol results in increased expression of HTRA1 mRNA CTD PMID:28069986 NCBI chr14:132,043,044...132,103,590
Ensembl chr14:132,043,006...132,103,595 		JBrowse link
G ITIH5 inter-alpha-trypsin inhibitor heavy chain 5 increases expression EXP Ethanol results in increased expression of ITIH5 mRNA CTD PMID:28069986 NCBI chr10:63,688,416...63,764,566
Ensembl chr10:63,688,406...63,767,125 		JBrowse link
G KIAA1217 KIAA1217 increases expression EXP Ethanol results in increased expression of KIAA1217 mRNA CTD PMID:28069986 NCBI chr10:50,706,713...51,032,010
Ensembl chr10:50,706,711...51,205,618 		JBrowse link
G KRT6A keratin 6A increases expression EXP Ethanol results in increased expression of KRT6A mRNA CTD PMID:28069986 NCBI chr 5:17,830,147...17,851,113
Ensembl chr 5:17,780,928...17,868,402 		JBrowse link
G LOC100513346 mitochondrial import inner membrane translocase subunit TIM16 decreases expression EXP Ethanol results in decreased expression of PAM16 mRNA CTD PMID:28069986 NCBI chr 3:37,928,098...38,005,619
Ensembl chr 3:37,989,180...38,005,617 		JBrowse link
G MAP1S microtubule associated protein 1S decreases expression EXP Ethanol results in decreased expression of MAP1S mRNA CTD PMID:28069986 NCBI chr 2:60,003,116...60,043,133
Ensembl chr 2:59,999,162...60,029,939 		JBrowse link
G MIOX myo-inositol oxygenase decreases expression EXP Ethanol results in decreased expression of MIOX mRNA CTD PMID:28069986 NCBI chr 5:249,312...251,547 JBrowse link
G MKNK2 MAPK interacting serine/threonine kinase 2 decreases expression EXP Ethanol results in decreased expression of MKNK2 mRNA CTD PMID:28069986 NCBI chr 2:76,510,302...76,522,885
Ensembl chr 2:76,510,303...76,522,885 		JBrowse link
G NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 increases expression EXP Ethanol results in increased expression of NAALAD2 mRNA CTD PMID:28069986 NCBI chr 9:23,106,795...23,161,825
Ensembl chr 9:23,111,051...23,161,839 		JBrowse link
G PLEKHO1 pleckstrin homology domain containing O1 increases expression EXP Ethanol results in increased expression of PLEKHO1 mRNA CTD PMID:28069986 NCBI chr 4:98,924,115...98,934,610
Ensembl chr 4:98,923,996...98,934,371 		JBrowse link
G PRKD3 protein kinase D3 increases expression EXP Ethanol results in increased expression of PRKD3 mRNA CTD PMID:28069986 NCBI chr 3:102,840,666...102,949,128
Ensembl chr 3:102,842,229...102,944,085 		JBrowse link
G PRNP prion protein increases expression EXP Ethanol results in increased expression of PRNP mRNA CTD PMID:28069986 NCBI chr17:13,694,195...13,705,126
Ensembl chr17:13,693,628...13,705,318 		JBrowse link
G RPL13A ribosomal protein L13a decreases expression EXP Ethanol results in decreased expression of RPL13A mRNA CTD PMID:28069986 NCBI chr 6:54,551,772...54,568,752 JBrowse link
G SAFB scaffold attachment factor B increases expression EXP Ethanol results in increased expression of SAFB mRNA CTD PMID:28069986 NCBI chr 2:73,300,624...73,334,494
Ensembl chr 2:73,300,632...73,334,494 		JBrowse link
G SLC7A4 solute carrier family 7 member 4 decreases expression EXP Ethanol results in decreased expression of SLC7A4 mRNA CTD PMID:28069986 NCBI chr14:50,631,693...50,638,381
Ensembl chr14:50,633,878...50,637,404 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
decreases activity		 EXP [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
Ethanol results in decreased activity of SOD1 protein		 CTD PMID:16792574 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity		 EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Ethanol results in increased activity of SOD2 protein		 CTD PMID:16792574 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723 		JBrowse link
G SRGN serglycin increases expression EXP Ethanol results in increased expression of SRGN mRNA CTD PMID:28069986 NCBI chr14:72,183,368...72,199,262
Ensembl chr14:72,183,363...72,199,254 		JBrowse link
G STXBP2 syntaxin binding protein 2 decreases expression EXP Ethanol results in decreased expression of STXBP2 mRNA CTD PMID:28069986 NCBI chr 2:71,504,575...71,513,446
Ensembl chr 2:71,504,569...71,513,422 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP Ethanol results in increased expression of TIMP2 mRNA CTD PMID:28069986 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835 		JBrowse link
G TMEM98 transmembrane protein 98 increases expression EXP Ethanol results in increased expression of TMEM98 mRNA CTD PMID:28069986 NCBI chr12:42,087,691...42,101,152
Ensembl chr12:42,083,553...42,100,494 		JBrowse link
G TNNI3 troponin I3, cardiac type decreases expression EXP Ethanol results in decreased expression of TNNI3 mRNA CTD PMID:28069986 NCBI chr 6:59,366,828...59,377,490
Ensembl chr 6:59,366,828...59,382,728 		JBrowse link
G TRAPPC5 trafficking protein particle complex 5 decreases expression EXP Ethanol results in decreased expression of TRAPPC5 mRNA CTD PMID:28069986 NCBI chr 2:71,470,441...71,472,614
Ensembl chr 2:71,470,445...71,472,549 		JBrowse link
G TRPT1 tRNA phosphotransferase 1 decreases expression EXP Ethanol results in decreased expression of TRPT1 mRNA CTD PMID:28069986 NCBI chr 2:7,876,028...7,887,589
Ensembl chr 2:7,883,988...7,888,134 		JBrowse link
G WFDC1 WAP four-disulfide core domain 1 increases expression EXP Ethanol results in increased expression of WFDC1 mRNA CTD PMID:28069986 NCBI chr 6:4,333,729...4,365,122
Ensembl chr 6:4,333,731...4,399,237 		JBrowse link
G WNT5B Wnt family member 5B increases expression EXP Ethanol results in increased expression of WNT5B mRNA CTD PMID:28069986 NCBI chr 5:68,627,158...68,731,938
Ensembl chr 5:68,627,151...68,731,935 		JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT2 AKT serine/threonine kinase 2 increases expression EXP Malathion results in increased expression of AKT2 mRNA CTD PMID:31535366 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,789...48,587,919 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Malathion results in increased expression of BAX mRNA CTD PMID:31535366 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP Malathion results in decreased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]		 CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CAT catalase decreases expression
multiple interactions		 EXP Malathion results in decreased expression of CAT mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]		 CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases expression EXP Malathion results in decreased expression of CYP1A1 mRNA CTD PMID:31535366 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases expression EXP Malathion results in decreased expression of CYP1B1 mRNA CTD PMID:31535366 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,206,750 		JBrowse link
G DUOX2 dual oxidase 2 decreases expression EXP Malathion results in decreased expression of DUOX2 mRNA CTD PMID:31535366 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,477...126,641,419 		JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Malathion results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886 		JBrowse link
G GPX6 glutathione peroxidase 6 increases expression EXP Malathion results in increased expression of GPX6 mRNA CTD PMID:31535366 NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases expression EXP Malathion results in decreased expression of GSTA1 mRNA CTD PMID:31535366 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I affects expression EXP Malathion affects the expression of COX1 mRNA CTD PMID:17454254 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055 		JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III affects expression EXP Malathion affects the expression of COX3 mRNA CTD PMID:17454254 NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583 		JBrowse link
G PLIN2 perilipin 2 multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]
Malathion results in decreased expression of PLIN2 mRNA; Malathion results in decreased expression of PLIN2 protein		 CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,274 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression		 EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]
Malathion results in decreased expression of PPARG mRNA; Malathion results in decreased expression of PPARG protein		 CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947 		JBrowse link
G SLC34A2 solute carrier family 34 member 2 increases expression EXP Malathion results in increased expression of SLC34A2 mRNA CTD PMID:31535366 NCBI chr 8:19,481,127...19,507,903
Ensembl chr 8:19,481,198...19,509,667 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Malathion results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723 		JBrowse link
G SORD sorbitol dehydrogenase increases expression EXP Malathion results in increased expression of SORD mRNA CTD PMID:31535366 NCBI chr 1:126,659,198...126,701,084
Ensembl chr 1:126,655,135...126,700,858 		JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions		 EXP Malathion results in increased expression of TP53 mRNA
Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]		 CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819 		JBrowse link
nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295 		JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,402...41,972,301 		JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion		 EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein		 CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,596,235...120,627,806
Ensembl chr 1:120,367,667...120,695,899 		JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683 		JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion		 EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein		 CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405 		JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795 		JBrowse link
G LAMB1 laminin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of LAMB1 mRNA CTD PMID:32423882 NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases expression
decreases phosphorylation		 EXP Nicotine results in decreased expression of MAPK1 mRNA
Nicotine results in decreased phosphorylation of MAPK1 protein		 CTD PMID:32423882 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
decreases expression		 EXP Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA		 CTD PMID:32423882 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases expression
decreases phosphorylation		 EXP Nicotine results in decreased expression of MAPK8 mRNA
Nicotine results in decreased phosphorylation of MAPK8 protein		 CTD PMID:32423882 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200 		JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Nicotine results in increased expression of MMP9 mRNA CTD PMID:32423882 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264 		JBrowse link
G OCLN occludin decreases expression EXP Nicotine results in decreased expression of OCLN mRNA CTD PMID:32423882 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033 		JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 decreases expression EXP Nicotine results in decreased expression of RPP38 mRNA CTD PMID:32423882 NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,195...46,725,920 		JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of AKT1 protein CTD PMID:30287338
G ANXA5 annexin A5 decreases expression EXP ochratoxin A results in decreased expression of ANXA5 mRNA CTD PMID:14994279 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750 		JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression		 EXP ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of ATG5 protein		 CTD PMID:28699257 PMID:30287338 NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,453 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
affects expression
multiple interactions		 EXP ochratoxin A results in decreased expression of BCL2 mRNA
ochratoxin A affects the expression of BCL2 mRNA
TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]		 CTD PMID:28528741 PMID:29080797 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879 		JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression		 EXP BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of BECN1 protein		 CTD PMID:30287338 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G BRCA1 BRCA1 DNA repair associated increases expression EXP ochratoxin A results in increased expression of BRCA1 protein CTD PMID:32454083 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage		 EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G CAT catalase decreases expression EXP ochratoxin A results in decreased expression of CAT protein CTD PMID:18547704 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CRYAB crystallin alpha B increases expression EXP ochratoxin A results in increased expression of CRYAB mRNA CTD PMID:14994279 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530 		JBrowse link
G CYP2G2 cytochrome P450 family 2 subfamily G member 2 decreases expression EXP ochratoxin A results in decreased expression of CYP2A6 mRNA CTD PMID:14994279 NCBI chr 6:49,069,613...49,084,953 JBrowse link
G DAD1 defender against cell death 1 decreases expression EXP ochratoxin A results in decreased expression of DAD1 mRNA CTD PMID:14994279 NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,029...76,457,192 		JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein
Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]		 CTD PMID:29080797 PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression EXP ochratoxin A results in increased expression of DNMT3A mRNA CTD PMID:29080797 PMID:30923867 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit decreases expression
multiple interactions		 EXP ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]		 CTD PMID:18547363 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535 		JBrowse link
G GLMN glomulin, FKBP associated protein increases expression EXP ochratoxin A results in increased expression of GLMN mRNA CTD PMID:14994279 NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,979...124,813,337 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
decreases expression		 EXP ochratoxin A inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]
ochratoxin A results in decreased expression of GSTA1 mRNA		 CTD PMID:18547363 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728 		JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions
increases expression		 EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]
ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein		 CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
decreases expression		 EXP ochratoxin A results in increased expression of HSP90B1 mRNA
ochratoxin A results in decreased expression of HSP90B1 mRNA		 CTD PMID:14994279 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein CTD PMID:28699257 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP ochratoxin A results in decreased expression of HSPD1 mRNA CTD PMID:14994279 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527 		JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression EXP ochratoxin A results in decreased expression of ID2 mRNA CTD PMID:14994279 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,759...127,503,257 		JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression EXP ochratoxin A results in increased expression of IGFBP2 mRNA CTD PMID:14994279 NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] CTD PMID:28528741 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119 		JBrowse link
G IL2 interleukin 2 decreases secretion EXP ochratoxin A results in decreased secretion of IL2 protein CTD PMID:28699257 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL4 interleukin 4 increases expression EXP ochratoxin A results in increased expression of IL4 mRNA CTD PMID:14994279 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of IL6 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]		 CTD PMID:28710020 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263 		JBrowse link
G JAK2 Janus kinase 2 multiple interactions
increases phosphorylation		 EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein] CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148 		JBrowse link
G LOC100522201 histone H2AX multiple interactions
increases expression		 EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP ochratoxin A results in increased phosphorylation of MAPK1 protein
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]		 CTD PMID:28528741 PMID:28699257 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
ochratoxin A results in increased phosphorylation of MAPK3 protein		 CTD PMID:28528741 PMID:28699257 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of MTOR protein CTD PMID:30287338 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:28528741 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109 		JBrowse link
G NEIL1 nei like DNA glycosylase 1 decreases expression
multiple interactions		 EXP ochratoxin A results in decreased expression of NEIL1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]		 CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092 		JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
decreases expression		 EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA] CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310 		JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity
multiple interactions
decreases expression		 EXP ochratoxin A results in decreased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforafan affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of NFE2L2 mRNA]
ochratoxin A results in decreased expression of NFE2L2 mRNA		 CTD PMID:18547363 PMID:18547704 PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183 		JBrowse link
G NPM1 nucleophosmin 1 increases expression EXP ochratoxin A results in increased expression of NPM1 mRNA CTD PMID:14994279 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,296...52,781,740 		JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions		 EXP ochratoxin A results in decreased expression of OGG1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]		 CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions		 EXP ochratoxin A results in increased cleavage of PARP1 protein
ochratoxin A results in increased expression of PARP1 protein
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]		 CTD PMID:30287338 PMID:32454083 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein CTD PMID:3753873 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896 		JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP ochratoxin A results in decreased expression of PCNA protein CTD PMID:32454083 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276 		JBrowse link
G PFDN5 prefoldin subunit 5 decreases expression EXP ochratoxin A results in decreased expression of PFDN5 mRNA CTD PMID:14994279 NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,719...18,525,877 		JBrowse link
G PPIA peptidylprolyl isomerase A increases expression EXP ochratoxin A results in increased expression of PPIA mRNA CTD PMID:14994279 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP ochratoxin A results in decreased expression of PRDX1 mRNA CTD PMID:14994279 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442 		JBrowse link
G PTMA prothymosin alpha decreases expression EXP ochratoxin A results in decreased expression of PTMA mRNA CTD PMID:14994279 NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435 		JBrowse link
G RAD51 RAD51 recombinase increases expression EXP ochratoxin A results in increased expression of RAD51 protein CTD PMID:32454083 NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,647...130,640,136 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:28528741 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471 		JBrowse link
G RPA2 replication protein A2 increases expression EXP ochratoxin A results in increased expression of RPA2 protein CTD PMID:32454083 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,578...85,045,916 		JBrowse link
G RPS5 ribosomal protein S5 increases expression EXP ochratoxin A results in increased expression of RPS5 mRNA CTD PMID:14994279 NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,921,635...62,974,354 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein
Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]		 CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012 		JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP ochratoxin A results in decreased activity of SOD1 protein CTD PMID:18547704 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression		 EXP Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein] CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation		 EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993 		JBrowse link
G SUMO1 small ubiquitin like modifier 1 decreases expression EXP ochratoxin A results in decreased expression of SUMO1 mRNA CTD PMID:14994279 NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of TGFB1 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforafan inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]		 CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP ochratoxin A results in increased expression of TIMP2 mRNA CTD PMID:14994279 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835 		JBrowse link
G TJP1 tight junction protein 1 affects localization EXP ochratoxin A affects the localization of TJP1 protein CTD PMID:14994279 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:28528741 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion		 EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
ochratoxin A results in increased secretion of TNF protein		 CTD PMID:28528741 PMID:28699257 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression		 EXP NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein] CTD PMID:28710020 PMID:32454083 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819 		JBrowse link
G XPA XPA, DNA damage recognition and repair factor decreases expression EXP ochratoxin A results in decreased expression of XPA mRNA CTD PMID:14994279 NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 increases expression EXP ochratoxin A results in increased expression of XRCC1 protein CTD PMID:32454083 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710 		JBrowse link
salubrinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP salubrinal results in increased phosphorylation of EIF2A protein CTD PMID:17464326 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 875
    role 855
      biological role 855
        aetiopathogenetic role 455
          teratogenic agent 176
            (S)-nicotine + 20
            (S)-thalidomide + 0
            1,1-dimethylhydrazine 0
            2-(2-methoxyethoxy)ethanol 0
            2-amino-6-hydroxyaminopurine 0
            2-ethoxyethanol + 0
            6-aminonicotinamide 0
            BMS-453 0
            Evans blue 0
            Evans blue free acid 0
            N(6)-hydroxyadenine 0
            N-methyl-N-nitrosourea 0
            acetaldehyde + 1
            acetylsalicylic acid + 3
            ammodendrine 0
            anabasine + 0
            arotinoid acid 6
            azetidine-2-carboxylic acid + 0
            busulfan 0
            dibutyl phthalate 0
            diethyl phthalate 0
            diisobutyl phthalate 0
            dinocap 0
            ethanol + 98
            ethyl methanesulfonate 0
            flubendazole 0
            flumioxazin 0
            flumipropyn 0
            hadacidin 0
            hydroxyurea 0
            isotretinoin 0
            malachite green 0
            mevinolinic acid 0
            nicotine + 20
            ochratoxin A + 61
            phenytoin 0
            solasodine + 0
            soraphen A 0
            tazarotene 0
            tazarotenic acid + 0
            thalidomide + 0
            valproic acid + 0
            valpromide 0
            vismodegib 0
paths to the root