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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ciprofibrate
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Accession:CHEBI:50867 term browser browse the term
Definition:A cyclopropane that has formula C13H14Cl2O3.
Synonyms:exact_synonym: 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
 related_synonym: Formula=C13H14Cl2O3;   InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17);   InChIKey=KPSRODZRAIWAKH-UHFFFAOYSA-N;   SMILES=CC(C)(Oc1ccc(cc1)C1CC1(Cl)Cl)C(O)=O;   ciprofibrato;   ciprofibratum
 xref: CAS:52214-84-3;   Drug_Central:658;   KEGG:D03521;   LINCS:LSM-1600
 xref_mesh: MESH:C019304
 xref: Patent:DE2343606;   Patent:US3948973;   Reaxys:1984981;   Wikipedia:Ciprofibrate


show annotations for term's descendants           Sort by:
ciprofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO ciprofibrate results in decreased expression of ABCB11 protein CTD PMID:12381268 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO ciprofibrate results in increased expression of ABCB1A mRNA CTD PMID:12381268 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression ISO ciprofibrate results in increased expression of ABCB1B mRNA CTD PMID:12381268 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO ciprofibrate results in increased expression of ABCB4 mRNA; ciprofibrate results in increased expression of ABCB4 protein CTD PMID:12381268 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression 		ISO [ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA
ciprofibrate results in increased expression of ABCC3 mRNA 		CTD PMID:15833929 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO ciprofibrate results in increased expression of ACAA1A mRNA CTD PMID:12771043 NCBI chr 8:127,956,126...127,966,348
Ensembl chr 8:127,956,129...127,966,241 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP ciprofibrate results in increased expression of ACAA2 mRNA CTD PMID:27225895 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO
EXP 		ciprofibrate results in increased expression of ACOT1 mRNA CTD PMID:27225895 NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:109,367,268...109,380,749 		JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP
ISO 		ciprofibrate results in increased expression of ACOT2 mRNA CTD PMID:27225895 NCBI chr 6:109,341,426...109,352,818
Ensembl chr 6:109,342,646...109,350,502 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression EXP
ISO 		ciprofibrate results in increased expression of ACOT3 mRNA CTD PMID:27225895 NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:109,413,534...109,421,427
Ensembl chr 6:109,413,534...109,421,427 		JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP
ISO 		ciprofibrate results in increased expression of ACOT4 mRNA CTD PMID:27225895 NCBI chr 6:109,399,032...109,405,138
Ensembl chr 6:109,399,578...109,405,138 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases activity
multiple interactions
increases expression 		EXP
ISO 		ciprofibrate results in increased activity of ACOX1 protein
[ciprofibrate co-treated with Fatty Acids, Unsaturated deficiency] results in increased expression of ACOX1 mRNA
ciprofibrate results in increased expression of ACOX1 mRNA 		CTD PMID:8001245 PMID:11172741 PMID:12771043 PMID:19544052 PMID:24986865 More... NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP ciprofibrate results in increased expression of ACSL1 mRNA CTD PMID:27225895 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO ciprofibrate results in increased expression of ADAMTS1 mRNA CTD PMID:12771043 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390 		JBrowse link
G Aig1 androgen-induced 1 increases expression ISO ciprofibrate results in increased expression of AIG1 mRNA CTD PMID:12771043 NCBI chr 1:9,866,546...10,089,454
Ensembl chr 1:9,866,548...10,089,155 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
decreases activity 		ISO ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
ciprofibrate results in decreased activity of AKR1B10 protein; ciprofibrate results in decreased activity of AKR1B10 protein mutant form 		CTD PMID:18325492 PMID:19028477 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO
EXP 		ciprofibrate results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 PMID:27225895 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO ciprofibrate results in increased expression of ALDH3A2 mRNA CTD PMID:17998271 NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648 		JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression ISO ciprofibrate results in increased expression of ALDH9A1 mRNA CTD PMID:17998271 NCBI chr13:82,038,679...82,055,478
Ensembl chr13:82,038,533...82,055,481 		JBrowse link
G Anxa2 annexin A2 increases expression ISO ciprofibrate results in increased expression of ANXA2 mRNA CTD PMID:12771043 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631 		JBrowse link
G Apcs amyloid P component, serum increases expression ISO ciprofibrate results in increased expression of APCS mRNA CTD PMID:12771043 NCBI chr13:87,905,532...87,906,508
Ensembl chr13:87,905,532...87,928,824 		JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO ciprofibrate results in decreased expression of APOA1 mRNA CTD PMID:7983038 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G Asgr1 asialoglycoprotein receptor 1 decreases expression EXP ciprofibrate results in decreased expression of ASGR1 protein CTD PMID:2404574 NCBI chr10:55,274,299...55,278,323
Ensembl chr10:55,274,706...55,278,322 		JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression ISO ciprofibrate results in decreased expression of BAAT mRNA CTD PMID:12771043 NCBI chr 5:68,647,166...68,656,137
Ensembl chr 5:68,646,203...68,656,181 		JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases activity
increases expression 		EXP ciprofibrate results in decreased activity of BDH1 protein
ciprofibrate results in increased expression of BDH1 mRNA 		CTD PMID:1777922 NCBI chr11:82,806,125...82,848,133
Ensembl chr11:82,807,503...82,842,636 		JBrowse link
G C9 complement C9 decreases expression ISO ciprofibrate results in decreased expression of C9 mRNA CTD PMID:12771043 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:57,300,427...57,348,752 		JBrowse link
G Cat catalase multiple interactions
increases expression
increases activity 		EXP [Dexamethasone co-treated with ciprofibrate] results in increased expression of CAT protein
ciprofibrate results in increased expression of CAT protein
ciprofibrate results in increased activity of CAT protein 		CTD PMID:1740018 PMID:9736482 PMID:15965953 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO ciprofibrate results in increased expression of CBR1 mRNA CTD PMID:12771043 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO ciprofibrate results in decreased expression of CCND2 mRNA; ciprofibrate results in decreased expression of CCND2 protein CTD PMID:12649303 NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:161,653,048...161,680,301
Ensembl chr 4:161,653,048...161,680,301 		JBrowse link
G Cd14 CD14 molecule increases expression ISO ciprofibrate results in increased expression of CD14 protein CTD PMID:12649303 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292 		JBrowse link
G Cd36 CD36 molecule increases expression ISO ciprofibrate results in increased expression of CD36 mRNA CTD PMID:12771043 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Cd63 Cd63 molecule increases expression ISO ciprofibrate results in increased expression of CD63 mRNA CTD PMID:12771043 NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,922,169...1,924,938 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO ciprofibrate results in increased expression of COL4A2 mRNA CTD PMID:12771043 NCBI chr16:84,749,672...84,885,520
Ensembl chr16:84,749,672...84,885,520 		JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP
ISO 		ciprofibrate results in increased expression of CPT1B mRNA CTD PMID:27225895 NCBI chr 7:122,370,974...122,380,473
Ensembl chr 7:122,370,444...122,380,036 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP
ISO 		ciprofibrate results in increased expression of CPT2 mRNA CTD PMID:27225895 NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:127,893,207...127,910,818 		JBrowse link
G Crat carnitine O-acetyltransferase increases expression ISO ciprofibrate results in increased expression of CRAT mRNA CTD PMID:12771043 NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:34,073,506...34,087,099 		JBrowse link
G Ctsb cathepsin B increases expression ISO ciprofibrate results in increased expression of CTSB mRNA CTD PMID:12771043 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Ctsl cathepsin L increases expression ISO ciprofibrate results in increased expression of CTSL mRNA CTD PMID:12771043 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO ciprofibrate results in decreased expression of CXCL12 mRNA CTD PMID:12771043 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions 		EXP
ISO 		ciprofibrate results in decreased expression of CYP1A2 mRNA
ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA] 		CTD PMID:7676460 PMID:17962186 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO ciprofibrate results in decreased expression of CYP26A1 mRNA CTD PMID:12771043 NCBI chr 1:244,883,822...244,887,657
Ensembl chr 1:244,883,752...244,887,657 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions 		EXP ciprofibrate results in increased expression of CYP2B1 mRNA
pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B1 protein] 		CTD PMID:7587954 PMID:27225895 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions 		EXP ciprofibrate results in increased expression of CYP2B2 mRNA
pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B2 protein] 		CTD PMID:7587954 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions 		ISO ciprofibrate results in decreased expression of CYP2B10 mRNA
ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]; ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA] 		CTD PMID:17962186 PMID:27225895 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases expression ISO ciprofibrate results in decreased expression of CYP2C29 mRNA CTD PMID:12771043 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression 		EXP [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Thiazoles co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]
ciprofibrate results in increased expression of CYP2E1 mRNA 		CTD PMID:7587954 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP ciprofibrate results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
multiple interactions 		EXP ciprofibrate results in increased expression of CYP3A23-3A1 mRNA
INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A23-3A1 mRNA] 		CTD PMID:10215695 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases activity
increases expression 		EXP ciprofibrate results in increased activity of CYP4A1 protein
ciprofibrate results in increased expression of CYP4A1 mRNA; ciprofibrate results in increased expression of CYP4A1 protein 		CTD PMID:2390105 PMID:7587954 PMID:7676460 PMID:19647067 PMID:27225895 NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231 		JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO ciprofibrate results in decreased expression of CYP4F14 mRNA CTD PMID:12771043 NCBI chr 7:12,661,357...12,672,952
Ensembl chr 7:12,661,359...12,672,612 		JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO ciprofibrate results in decreased expression of CYP7B1 mRNA CTD PMID:12771043 NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804 		JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression EXP ciprofibrate results in decreased expression of DPP4 protein CTD PMID:2404574 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP ciprofibrate results in increased expression of ECH1 protein CTD PMID:1740018 NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP ciprofibrate results in decreased expression of EGFR protein CTD PMID:2404574 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO
EXP 		ciprofibrate results in increased expression of EHHADH mRNA CTD PMID:2390105 PMID:12771043 PMID:27225895 NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 decreases expression ISO ciprofibrate results in decreased expression of ELOVL3 mRNA CTD PMID:12771043 NCBI chr 1:254,938,731...254,942,559
Ensembl chr 1:254,938,731...254,942,559 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO ciprofibrate results in increased expression of ETS2 mRNA CTD PMID:12771043 NCBI chr11:48,491,057...48,507,843
Ensembl chr11:48,491,394...48,507,842 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP
ISO 		ciprofibrate results in increased expression of FABP1 mRNA CTD PMID:27225895 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO ciprofibrate results in increased expression of FABP4 mRNA CTD PMID:12771043 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ciprofibrate analog results in increased expression of FOS mRNA CTD PMID:8764118 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases activity
decreases expression 		EXP ciprofibrate results in decreased activity of GCLC protein
ciprofibrate results in decreased expression of GCLC mRNA 		CTD PMID:7676460 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions EXP [Diethylnitrosamine co-treated with ciprofibrate] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with ciprofibrate] results in decreased expression of GJB1 protein CTD PMID:1973356 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:70,541,862...70,549,843 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP ciprofibrate results in decreased activity of GPX1 protein CTD PMID:19544052 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP ciprofibrate results in decreased expression of GSTA1 mRNA CTD PMID:7676460 NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:31,199,888...31,211,528 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP ciprofibrate results in decreased expression of GSTA2 mRNA CTD PMID:7676460 NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092 		JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP ciprofibrate results in decreased expression of GSTA3 mRNA CTD PMID:7676460 NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654 		JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression ISO ciprofibrate results in increased expression of GSTK1 mRNA CTD PMID:18723825 NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:72,085,531...72,089,927 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP ciprofibrate results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP ciprofibrate results in increased expression of HADHB mRNA CTD PMID:27225895 NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835 		JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO ciprofibrate results in increased expression of HDAC1 mRNA CTD PMID:12771043 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP ciprofibrate results in increased expression of HGF protein CTD PMID:1370768 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO ciprofibrate results in increased expression of HMGCS2 mRNA CTD PMID:12381268 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242 		JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 increases expression ISO ciprofibrate results in increased expression of HSD17B11 mRNA CTD PMID:12771043 NCBI chr14:5,997,893...6,047,816
Ensembl chr14:5,997,906...6,047,811 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP ciprofibrate results in increased expression of HSD17B4 mRNA CTD PMID:9209713 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467 		JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression ISO ciprofibrate results in decreased expression of HSD3B3 mRNA CTD PMID:12771043 NCBI chr 2:188,826,756...188,832,734
Ensembl chr 2:188,826,110...188,904,981 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO ciprofibrate results in increased expression of IGFBP1 mRNA CTD PMID:12771043 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO ciprofibrate results in increased expression of IGFBP2 mRNA CTD PMID:12771043 NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:81,864,783...81,892,171 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15968640 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein decreases expression ISO ciprofibrate results in decreased expression of IL1RAP mRNA CTD PMID:12771043 NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342 		JBrowse link
G Impact impact RWD domain protein increases expression ISO ciprofibrate results in increased expression of IMPACT mRNA CTD PMID:12771043 NCBI chr18:4,383,546...4,422,280
Ensembl chr18:4,383,575...4,422,278 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:10215695 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Itln1 intelectin 1 increases expression ISO ciprofibrate results in increased expression of ITLN1 mRNA CTD PMID:12771043 NCBI chr13:86,464,641...86,490,655
Ensembl chr13:86,464,669...86,490,651 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ciprofibrate analog results in increased expression of JUN mRNA CTD PMID:8764118 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression 		ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [ciprofibrate analog results in increased expression of JUNB mRNA] CTD PMID:8764118 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Krt8 keratin 8 increases expression ISO ciprofibrate results in increased expression of KRT8 mRNA CTD PMID:12771043 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO ciprofibrate results in increased expression of LCN2 mRNA CTD PMID:12771043 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Lgals3bp galectin 3 binding protein increases expression ISO ciprofibrate results in increased expression of LGALS3BP mRNA CTD PMID:12771043 NCBI chr10:104,118,510...104,127,848
Ensembl chr10:104,118,510...104,127,848 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 increases expression ISO ciprofibrate results in increased expression of LPCAT3 mRNA CTD PMID:12771043 NCBI chr 4:159,154,690...159,196,176
Ensembl chr 4:159,154,158...159,196,358 		JBrowse link
G Lpl lipoprotein lipase increases expression
increases activity 		ISO ciprofibrate results in increased expression of LPL mRNA
ciprofibrate results in increased activity of LPL protein 		CTD PMID:8593127 PMID:12771043 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO ciprofibrate results in increased expression of LY6D mRNA CTD PMID:12771043 NCBI chr 7:108,532,207...108,533,943
Ensembl chr 7:108,532,215...108,533,716 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO ciprofibrate results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875 		JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO ciprofibrate results in decreased expression of MYB mRNA; ciprofibrate results in decreased expression of MYB protein CTD PMID:12649303 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:17,759,309...17,792,547 		JBrowse link
G Myh1 myosin heavy chain 1 decreases expression ISO ciprofibrate results in decreased expression of MYH1 mRNA CTD PMID:12771043 NCBI chr10:52,384,810...52,408,698
Ensembl chr10:52,384,908...52,409,047 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO ciprofibrate results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases response to substance ISO NFKB1 results in increased susceptibility to ciprofibrate CTD PMID:16434500 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP ciprofibrate results in increased expression of NQO1 mRNA CTD PMID:7676460 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression ISO ciprofibrate results in decreased expression of NR1H3 mRNA CTD PMID:12771043 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
multiple interactions
increases expression
increases activity 		ISO
EXP 		ciprofibrate affects the localization of NR1I3 protein
ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]
ciprofibrate results in increased expression of NR1I3 mRNA; ciprofibrate results in increased expression of NR1I3 protein
ciprofibrate results in increased activity of NR1I3 protein 		CTD PMID:17962186 PMID:20208394 PMID:25949234 PMID:30203046 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370 		JBrowse link
G Oat ornithine aminotransferase decreases expression ISO ciprofibrate results in decreased expression of OAT mRNA CTD PMID:12771043 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO ciprofibrate results in decreased expression of PAH mRNA CTD PMID:12771043 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627 		JBrowse link
G Palmd palmdelphin increases expression ISO ciprofibrate results in increased expression of PALMD mRNA CTD PMID:12771043 NCBI chr 2:207,574,413...207,626,239
Ensembl chr 2:207,574,249...207,626,239 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO
EXP 		ciprofibrate results in increased expression of PDK4 mRNA CTD PMID:12771043 PMID:27225895 NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381 		JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha increases expression ISO ciprofibrate results in increased expression of PEX11A mRNA CTD PMID:12771043 NCBI chr 1:143,089,410...143,096,491
Ensembl chr 1:143,089,410...143,096,645 		JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO ciprofibrate results in decreased expression of PHLDA1 mRNA CTD PMID:12771043 NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542 		JBrowse link
G Plin2 perilipin 2 increases expression ISO ciprofibrate results in increased expression of PLIN2 mRNA CTD PMID:12771043 PMID:23737761 NCBI chr 5:106,202,634...106,258,748
Ensembl chr 5:106,202,634...106,258,878 		JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO ciprofibrate results in increased expression of PLSCR1 mRNA CTD PMID:12771043 NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:101,664,056...101,684,614 		JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO ciprofibrate results in decreased expression of PON1 mRNA CTD PMID:22653878 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO ciprofibrate results in decreased expression of PON2 mRNA CTD PMID:22653878 NCBI chr 4:34,356,270...34,391,684
Ensembl chr 4:34,356,274...34,391,996 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
increases activity
affects response to substance 		ISO
EXP 		ciprofibrate binds to and results in increased activity of PPARA protein
ciprofibrate results in increased expression of PPARA mRNA
ciprofibrate results in increased activity of PPARA protein
[ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA; ciprofibrate binds to and results in increased activity of PPARA protein
PPARA protein affects the susceptibility to ciprofibrate 		CTD PMID:9688458 PMID:15833929 PMID:15853379 PMID:15919853 PMID:15968640 More... NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO ciprofibrate analog results in increased expression of PTGS2 mRNA; ciprofibrate analog results in increased expression of PTGS2 protein CTD PMID:9013627 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression ISO ciprofibrate results in increased expression of RBM3 mRNA CTD PMID:12771043 NCBI chr  X:17,020,863...17,024,341
Ensembl chr  X:17,020,864...17,024,841 		JBrowse link
G Retsat retinol saturase increases expression ISO
EXP 		ciprofibrate results in increased expression of RETSAT mRNA CTD PMID:27225895 NCBI chr 4:106,211,459...106,220,222
Ensembl chr 4:106,211,436...106,229,552 		JBrowse link
G Rpl12 ribosomal protein L12 increases expression ISO ciprofibrate results in increased expression of RPL12 mRNA CTD PMID:12771043 NCBI chr 3:36,661,940...36,664,314
Ensembl chr 3:36,661,939...36,664,306 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO ciprofibrate promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of SCD1 mRNA]; ciprofibrate results in increased expression of and results in increased degradation of SCD1 mRNA; Dactinomycin inhibits the reaction [ciprofibrate results in increased expression of SCD1 mRNA] CTD PMID:11172741 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO ciprofibrate results in decreased expression of SLC10A1 protein CTD PMID:12381268 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression ISO ciprofibrate results in increased expression of SLC16A1 mRNA CTD PMID:12771043 NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression EXP ciprofibrate results in increased expression of SLC25A20 mRNA CTD PMID:27225895 NCBI chr 8:118,243,573...118,265,027
Ensembl chr 8:118,243,519...118,265,027 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 increases expression ISO
EXP 		ciprofibrate results in increased expression of SLC25A34 mRNA CTD PMID:27225895 NCBI chr 5:159,215,120...159,219,892
Ensembl chr 5:159,215,120...159,219,892 		JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression ISO ciprofibrate results in decreased expression of SLC37A4 mRNA CTD PMID:12771043 NCBI chr 8:53,619,952...53,626,110
Ensembl chr 8:53,620,141...53,626,110 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO ciprofibrate results in increased expression of SLC4A4 mRNA CTD PMID:12771043 NCBI chr14:19,125,394...19,577,379
Ensembl chr14:19,129,264...19,577,435 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO ciprofibrate results in decreased expression of SLCO1B2 mRNA CTD PMID:15919853 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083 		JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO ciprofibrate results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:112,467,160...112,551,921 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression ISO ciprofibrate results in decreased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:163,371,410...163,419,412
Ensembl chr 1:163,371,410...163,419,279 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression
increases activity 		EXP ciprofibrate results in increased expression of SOD1 mRNA
ciprofibrate results in increased activity of SOD1 protein 		CTD PMID:7676460 PMID:19544052 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP ciprofibrate results in decreased activity of SOD2 protein CTD PMID:19544052 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO ciprofibrate results in increased expression of SQSTM1 mRNA CTD PMID:12771043 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO ciprofibrate results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:86,207,293...86,275,990 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
increases expression 		ISO ciprofibrate results in increased expression of and results in increased activity of SULT2A1 protein
ciprofibrate results in increased expression of SULT2A1 mRNA 		CTD PMID:15635043 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Tagln2 transgelin 2 increases expression ISO ciprofibrate results in increased expression of TAGLN2 mRNA CTD PMID:12771043 NCBI chr13:87,499,350...87,506,328
Ensembl chr13:87,499,394...87,506,330 		JBrowse link
G Tm4sf4 transmembrane 4 L six family member 4 increases expression ISO ciprofibrate results in increased expression of TM4SF4 mRNA CTD PMID:12771043 NCBI chr 2:143,720,220...143,771,283
Ensembl chr 2:143,720,267...143,771,227 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:15968640 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 decreases expression ISO ciprofibrate results in decreased expression of TRPV2 mRNA CTD PMID:12771043 NCBI chr10:47,772,223...47,797,956
Ensembl chr10:47,764,839...47,793,533 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ciprofibrate results in increased expression of UGT1A1 mRNA CTD PMID:19144771 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO ciprofibrate results in increased expression of UGT1A6 mRNA CTD PMID:19144771 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO ciprofibrate results in increased expression of UGT1A9 mRNA CTD PMID:19144771 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of ciprofibrate CTD PMID:8302279 NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,378,853...21,392,331 		JBrowse link
G Vnn3 vanin 3 increases expression ISO ciprofibrate results in increased expression of VNN3 mRNA CTD PMID:12771043 NCBI chr 1:23,390,596...23,402,858
Ensembl chr 1:23,390,596...23,402,858 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      application 20602
        pharmaceutical 20421
          drug 20398
            antilipemic drug 9392
              ciprofibrate 138
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbon oxoacid 19142
                                    carboxylic acid 19139
                                      monocarboxylic acid 18291
                                        ciprofibrate 138
paths to the root