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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ciprofibrate
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Accession:CHEBI:50867 term browser browse the term
Definition:A cyclopropane that has formula C13H14Cl2O3.
Synonyms:exact_synonym: 2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
 related_synonym: Formula=C13H14Cl2O3;   InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17);   InChIKey=KPSRODZRAIWAKH-UHFFFAOYSA-N;   SMILES=CC(C)(Oc1ccc(cc1)C1CC1(Cl)Cl)C(O)=O;   ciprofibrato;   ciprofibratum
 xref: Beilstein:1984981;   CAS:52214-84-3;   Drug_Central:658;   KEGG:D03521;   LINCS:LSM-1600
 xref_mesh: MESH:C019304
 xref: Patent:DE2343606;   Patent:US3948973;   Reaxys:1984981;   Wikipedia:Ciprofibrate



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ciprofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO ciprofibrate results in decreased expression of ABCB11 protein CTD PMID:12381268 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO ciprofibrate results in increased expression of ABCB1A mRNA CTD PMID:12381268 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression ISO ciprofibrate results in increased expression of ABCB1B mRNA CTD PMID:12381268 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO ciprofibrate results in increased expression of ABCB4 mRNA; ciprofibrate results in increased expression of ABCB4 protein CTD PMID:12381268 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression
ISO [ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA
ciprofibrate results in increased expression of ABCC3 mRNA
CTD PMID:15833929 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO ciprofibrate results in increased expression of ACAA1A mRNA CTD PMID:12771043 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 increases expression EXP ciprofibrate results in increased expression of ACAA2 mRNA CTD PMID:27225895 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO
EXP
ciprofibrate results in increased expression of ACOT1 mRNA CTD PMID:27225895 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP
ISO
ciprofibrate results in increased expression of ACOT2 mRNA CTD PMID:27225895 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression EXP
ISO
ciprofibrate results in increased expression of ACOT3 mRNA CTD PMID:27225895 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,723,326...103,729,482
JBrowse link
G Acot4 acyl-CoA thioesterase 4 increases expression EXP
ISO
ciprofibrate results in increased expression of ACOT4 mRNA CTD PMID:27225895 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acox1 acyl-CoA oxidase 1 increases activity
increases expression
multiple interactions
EXP
ISO
ciprofibrate results in increased activity of ACOX1 protein
ciprofibrate results in increased expression of ACOX1 mRNA
[ciprofibrate co-treated with Fatty Acids, Unsaturated deficiency] results in increased expression of ACOX1 mRNA
CTD PMID:8001245 PMID:11172741 PMID:12771043 PMID:19544052 PMID:24986865 More... NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression EXP ciprofibrate results in increased expression of ACSL1 mRNA CTD PMID:27225895 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO ciprofibrate results in increased expression of ADAMTS1 mRNA CTD PMID:12771043 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Aig1 androgen-induced 1 increases expression ISO ciprofibrate results in increased expression of AIG1 mRNA CTD PMID:12771043 NCBI chr 1:8,046,430...8,269,276
Ensembl chr 1:8,046,430...8,269,084
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions
decreases activity
ISO ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
ciprofibrate results in decreased activity of AKR1B10 protein; ciprofibrate results in decreased activity of AKR1B10 protein mutant form
CTD PMID:18325492 PMID:19028477 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO
EXP
ciprofibrate results in increased expression of ALDH1A1 mRNA CTD PMID:17998271 PMID:27225895 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO ciprofibrate results in increased expression of ALDH3A2 mRNA CTD PMID:17998271 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 increases expression ISO ciprofibrate results in increased expression of ALDH9A1 mRNA CTD PMID:17998271 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568
JBrowse link
G Anxa2 annexin A2 increases expression ISO ciprofibrate results in increased expression of ANXA2 mRNA CTD PMID:12771043 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Apcs amyloid P component, serum increases expression ISO ciprofibrate results in increased expression of APCS mRNA CTD PMID:12771043 NCBI chr13:85,373,338...85,374,134
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apoa1 apolipoprotein A1 decreases expression ISO ciprofibrate results in decreased expression of APOA1 mRNA CTD PMID:7983038 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Asgr1 asialoglycoprotein receptor 1 decreases expression EXP ciprofibrate results in decreased expression of ASGR1 protein CTD PMID:2404574 NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression ISO ciprofibrate results in decreased expression of BAAT mRNA CTD PMID:12771043 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase 1 decreases activity
increases expression
EXP ciprofibrate results in decreased activity of BDH1 protein
ciprofibrate results in increased expression of BDH1 mRNA
CTD PMID:1777922 NCBI chr11:69,302,534...69,343,173
Ensembl chr11:69,302,534...69,337,671
JBrowse link
G C9 complement C9 decreases expression ISO ciprofibrate results in decreased expression of C9 mRNA CTD PMID:12771043 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
EXP [Dexamethasone co-treated with ciprofibrate] results in increased expression of CAT protein
ciprofibrate results in increased activity of CAT protein
ciprofibrate results in increased expression of CAT protein
CTD PMID:1740018 PMID:9736482 PMID:15965953 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 increases expression ISO ciprofibrate results in increased expression of CBR1 mRNA CTD PMID:12771043 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO ciprofibrate results in decreased expression of CCND2 mRNA; ciprofibrate results in decreased expression of CCND2 protein CTD PMID:12649303 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Cd14 CD14 molecule increases expression ISO ciprofibrate results in increased expression of CD14 protein CTD PMID:12649303 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd36 CD36 molecule increases expression ISO ciprofibrate results in increased expression of CD36 mRNA CTD PMID:12771043 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd63 Cd63 molecule increases expression ISO ciprofibrate results in increased expression of CD63 mRNA CTD PMID:12771043 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO ciprofibrate results in increased expression of COL4A2 mRNA CTD PMID:12771043 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP
ISO
ciprofibrate results in increased expression of CPT1B mRNA CTD PMID:27225895 NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP
ISO
ciprofibrate results in increased expression of CPT2 mRNA CTD PMID:27225895 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crat carnitine O-acetyltransferase increases expression ISO ciprofibrate results in increased expression of CRAT mRNA CTD PMID:12771043 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
G Ctsb cathepsin B increases expression ISO ciprofibrate results in increased expression of CTSB mRNA CTD PMID:12771043 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsl cathepsin L increases expression ISO ciprofibrate results in increased expression of CTSL mRNA CTD PMID:12771043 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO ciprofibrate results in decreased expression of CXCL12 mRNA CTD PMID:12771043 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
EXP
ISO
ciprofibrate results in decreased expression of CYP1A2 mRNA
ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP1A2 mRNA]
CTD PMID:7676460 PMID:17962186 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases expression ISO ciprofibrate results in decreased expression of CYP26A1 mRNA CTD PMID:12771043 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
decreases expression
multiple interactions
EXP
ISO
ciprofibrate results in increased expression of CYP2B1 mRNA
ciprofibrate results in decreased expression of CYP2B10 mRNA
ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]; ciprofibrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B1 protein]
CTD PMID:7587954 PMID:17962186 PMID:27225895 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
multiple interactions
EXP ciprofibrate results in increased expression of CYP2B2 mRNA
pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2B2 protein]
CTD PMID:7587954 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases expression ISO ciprofibrate results in decreased expression of CYP2C29 mRNA CTD PMID:12771043
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
EXP [Acetone co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; [Thiazoles co-treated with ciprofibrate] results in increased expression of CYP2E1 protein; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]
ciprofibrate results in increased expression of CYP2E1 mRNA
CTD PMID:7587954 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression EXP ciprofibrate results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
multiple interactions
EXP ciprofibrate results in increased expression of CYP3A23-3A1 mRNA
INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A23-3A1 mRNA]
CTD PMID:10215695 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases activity
increases expression
EXP ciprofibrate results in increased activity of CYP4A1 protein
ciprofibrate results in increased expression of CYP4A1 mRNA; ciprofibrate results in increased expression of CYP4A1 protein
CTD PMID:2390105 PMID:7587954 PMID:7676460 PMID:19647067 PMID:27225895 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 decreases expression ISO ciprofibrate results in decreased expression of CYP4F14 mRNA CTD PMID:12771043 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases expression ISO ciprofibrate results in decreased expression of CYP7B1 mRNA CTD PMID:12771043 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Dpp4 dipeptidylpeptidase 4 decreases expression EXP ciprofibrate results in decreased expression of DPP4 protein CTD PMID:2404574 NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP ciprofibrate results in increased expression of ECH1 protein CTD PMID:1740018 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP ciprofibrate results in decreased expression of EGFR protein CTD PMID:2404574 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO
EXP
ciprofibrate results in increased expression of EHHADH mRNA CTD PMID:2390105 PMID:12771043 PMID:27225895 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 decreases expression ISO ciprofibrate results in decreased expression of ELOVL3 mRNA CTD PMID:12771043 NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor increases expression ISO ciprofibrate results in increased expression of ETS2 mRNA CTD PMID:12771043 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression EXP
ISO
ciprofibrate results in increased expression of FABP1 mRNA CTD PMID:27225895 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO ciprofibrate results in increased expression of FABP4 mRNA CTD PMID:12771043 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ciprofibrate analog results in increased expression of FOS mRNA CTD PMID:8764118 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases activity
decreases expression
EXP ciprofibrate results in decreased activity of GCLC protein
ciprofibrate results in decreased expression of GCLC mRNA
CTD PMID:7676460 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gjb1 gap junction protein, beta 1 multiple interactions EXP [Diethylnitrosamine co-treated with ciprofibrate] results in decreased expression of GJB1 protein; [Ethylnitrosourea co-treated with ciprofibrate] results in decreased expression of GJB1 protein CTD PMID:1973356 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity EXP ciprofibrate results in decreased activity of GPX1 protein CTD PMID:19544052 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression EXP ciprofibrate results in decreased expression of GSTA1 mRNA CTD PMID:7676460 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP ciprofibrate results in decreased expression of GSTA2 mRNA CTD PMID:7676460 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases expression EXP ciprofibrate results in decreased expression of GSTA3 mRNA CTD PMID:7676460 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression ISO ciprofibrate results in increased expression of GSTK1 mRNA CTD PMID:18723825 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP ciprofibrate results in decreased expression of GSTM1 mRNA CTD PMID:7676460 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression ISO ciprofibrate results in increased expression of GSTT2 mRNA CTD PMID:18723825 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP ciprofibrate results in increased expression of HADHB mRNA CTD PMID:27225895 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
JBrowse link
G Hdac1 histone deacetylase 1 increases expression ISO ciprofibrate results in increased expression of HDAC1 mRNA CTD PMID:12771043 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP ciprofibrate results in increased expression of HGF protein CTD PMID:1370768 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO ciprofibrate results in increased expression of HMGCS2 mRNA CTD PMID:12381268 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 increases expression ISO ciprofibrate results in increased expression of HSD17B11 mRNA CTD PMID:12771043 NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression EXP ciprofibrate results in increased expression of HSD17B4 mRNA CTD PMID:9209713 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression ISO ciprofibrate results in decreased expression of HSD3B3 mRNA CTD PMID:12771043 NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO ciprofibrate results in increased expression of IGFBP1 mRNA CTD PMID:12771043 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO ciprofibrate results in increased expression of IGFBP2 mRNA CTD PMID:12771043 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il12b interleukin 12B multiple interactions ISO ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:15968640 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:15968640 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rap interleukin 1 receptor accessory protein decreases expression ISO ciprofibrate results in decreased expression of IL1RAP mRNA CTD PMID:12771043 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530
JBrowse link
G Impact impact RWD domain protein increases expression ISO ciprofibrate results in increased expression of IMPACT mRNA CTD PMID:12771043 NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569
JBrowse link
G Ins2 insulin 2 multiple interactions EXP INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:10215695 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itln1 intelectin 1 increases expression ISO ciprofibrate results in increased expression of ITLN1 mRNA CTD PMID:12771043 NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO ciprofibrate analog results in increased expression of JUN mRNA CTD PMID:8764118 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [ciprofibrate analog results in increased expression of JUNB mRNA] CTD PMID:8764118 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Krt8 keratin 8 increases expression ISO ciprofibrate results in increased expression of KRT8 mRNA CTD PMID:12771043 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO ciprofibrate results in increased expression of LCN2 mRNA CTD PMID:12771043 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lgals3bp galectin 3 binding protein increases expression ISO ciprofibrate results in increased expression of LGALS3BP mRNA CTD PMID:12771043 NCBI chr10:103,619,912...103,629,251
Ensembl chr10:103,619,908...103,629,256
JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 increases expression ISO ciprofibrate results in increased expression of LPCAT3 mRNA CTD PMID:12771043 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880
JBrowse link
G Lpl lipoprotein lipase increases expression
increases activity
ISO ciprofibrate results in increased expression of LPL mRNA
ciprofibrate results in increased activity of LPL protein
CTD PMID:8593127 PMID:12771043 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Ly6d lymphocyte antigen 6 family member D increases expression ISO ciprofibrate results in increased expression of LY6D mRNA CTD PMID:12771043 NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO ciprofibrate results in increased expression of MGST1 mRNA CTD PMID:18723825 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO ciprofibrate results in decreased expression of MYB mRNA; ciprofibrate results in decreased expression of MYB protein CTD PMID:12649303 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057
JBrowse link
G Myh1 myosin heavy chain 1 decreases expression ISO ciprofibrate results in decreased expression of MYH1 mRNA CTD PMID:12771043 NCBI chr10:51,885,913...51,909,699 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO ciprofibrate results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases response to substance ISO NFKB1 results in increased susceptibility to ciprofibrate CTD PMID:16434500 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP ciprofibrate results in increased expression of NQO1 mRNA CTD PMID:7676460 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases expression ISO ciprofibrate results in decreased expression of NR1H3 mRNA CTD PMID:12771043 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
increases activity
increases expression
multiple interactions
ISO
EXP
ciprofibrate affects the localization of NR1I3 protein
ciprofibrate results in increased activity of NR1I3 protein
ciprofibrate results in increased expression of NR1I3 mRNA
ciprofibrate results in increased expression of NR1I3 mRNA; ciprofibrate results in increased expression of NR1I3 protein
ciprofibrate inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [NR1I3 protein binds to CYP2B10 promoter]]
CTD PMID:17962186 PMID:20208394 PMID:25949234 PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Oat ornithine aminotransferase decreases expression ISO ciprofibrate results in decreased expression of OAT mRNA CTD PMID:12771043 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO ciprofibrate results in decreased expression of PAH mRNA CTD PMID:12771043 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130
JBrowse link
G Palmd palmdelphin increases expression ISO ciprofibrate results in increased expression of PALMD mRNA CTD PMID:12771043 NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO
EXP
ciprofibrate results in increased expression of PDK4 mRNA CTD PMID:12771043 PMID:27225895 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha increases expression ISO ciprofibrate results in increased expression of PEX11A mRNA CTD PMID:12771043 NCBI chr 1:133,680,091...133,687,172
Ensembl chr 1:133,680,091...133,687,172
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO ciprofibrate results in decreased expression of PHLDA1 mRNA CTD PMID:12771043 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Plin2 perilipin 2 increases expression ISO ciprofibrate results in increased expression of PLIN2 mRNA CTD PMID:12771043 PMID:23737761 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO ciprofibrate results in increased expression of PLSCR1 mRNA CTD PMID:12771043 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Pon1 paraoxonase 1 decreases expression ISO ciprofibrate results in decreased expression of PON1 mRNA CTD PMID:22653878 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO ciprofibrate results in decreased expression of PON2 mRNA CTD PMID:22653878 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
increases expression
affects response to substance
ISO
EXP
ciprofibrate binds to and results in increased activity of PPARA protein
ciprofibrate results in increased activity of PPARA protein
ciprofibrate results in increased expression of PPARA mRNA
PPARA protein affects the susceptibility to ciprofibrate
[ciprofibrate binds to PPARA protein] which results in increased expression of ABCC3 mRNA; ciprofibrate binds to and results in increased activity of PPARA protein
CTD PMID:9688458 PMID:15833929 PMID:15853379 PMID:15919853 PMID:15968640 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO ciprofibrate analog results in increased expression of PTGS2 mRNA; ciprofibrate analog results in increased expression of PTGS2 protein CTD PMID:9013627 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rbm3 RNA binding motif protein 3 increases expression ISO ciprofibrate results in increased expression of RBM3 mRNA CTD PMID:12771043 NCBI chr  X:14,348,909...14,352,387
Ensembl chr  X:14,348,910...14,353,580
JBrowse link
G Retsat retinol saturase increases expression ISO
EXP
ciprofibrate results in increased expression of RETSAT mRNA CTD PMID:27225895 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
JBrowse link
G Rpl12 ribosomal protein L12 increases expression ISO ciprofibrate results in increased expression of RPL12 mRNA CTD PMID:12771043 NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO ciprofibrate promotes the reaction [Fatty Acids, Unsaturated deficiency results in increased expression of SCD1 mRNA]; ciprofibrate results in increased expression of and results in increased degradation of SCD1 mRNA; Dactinomycin inhibits the reaction [ciprofibrate results in increased expression of SCD1 mRNA] CTD PMID:11172741 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO ciprofibrate results in decreased expression of SLC10A1 protein CTD PMID:12381268 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression ISO ciprofibrate results in increased expression of SLC16A1 mRNA CTD PMID:12771043 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression EXP ciprofibrate results in increased expression of SLC25A20 mRNA CTD PMID:27225895 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
JBrowse link
G Slc25a34 solute carrier family 25, member 34 increases expression ISO
EXP
ciprofibrate results in increased expression of SLC25A34 mRNA CTD PMID:27225895 NCBI chr 5:153,932,081...153,936,854 JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression ISO ciprofibrate results in decreased expression of SLC37A4 mRNA CTD PMID:12771043 NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases expression ISO ciprofibrate results in increased expression of SLC4A4 mRNA CTD PMID:12771043 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO ciprofibrate results in decreased expression of SLCO1B2 mRNA CTD PMID:15919853 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2a1 solute carrier organic anion transporter family, member 2a1 decreases expression ISO ciprofibrate results in decreased expression of SLCO2A1 mRNA CTD PMID:15919853 NCBI chr 8:103,588,916...103,672,546
Ensembl chr 8:103,588,916...103,672,546
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression ISO ciprofibrate results in decreased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
increases activity
EXP ciprofibrate results in increased expression of SOD1 mRNA
ciprofibrate results in increased activity of SOD1 protein
CTD PMID:7676460 PMID:19544052 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP ciprofibrate results in decreased activity of SOD2 protein CTD PMID:19544052 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO ciprofibrate results in increased expression of SQSTM1 mRNA CTD PMID:12771043 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO ciprofibrate results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions
increases expression
ISO ciprofibrate results in increased expression of and results in increased activity of SULT2A1 protein
ciprofibrate results in increased expression of SULT2A1 mRNA
CTD PMID:15635043 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tagln2 transgelin 2 increases expression ISO ciprofibrate results in increased expression of TAGLN2 mRNA CTD PMID:12771043 NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
JBrowse link
G Tm4sf4 transmembrane 4 L six family member 4 increases expression ISO ciprofibrate results in increased expression of TM4SF4 mRNA CTD PMID:12771043 NCBI chr 2:141,570,321...141,621,263
Ensembl chr 2:141,481,902...141,621,200
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO ciprofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:15968640 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 decreases expression ISO ciprofibrate results in decreased expression of TRPV2 mRNA CTD PMID:12771043 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO ciprofibrate results in increased expression of UGT1A1 mRNA CTD PMID:19144771 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO ciprofibrate results in increased expression of UGT1A6 mRNA CTD PMID:19144771 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO ciprofibrate results in increased expression of UGT1A9 mRNA CTD PMID:19144771 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of ciprofibrate CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Vnn3 vanin 3 increases expression ISO ciprofibrate results in increased expression of VNN3 mRNA CTD PMID:12771043 NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pharmaceutical 19351
          drug 19351
            antilipemic drug 6457
              ciprofibrate 138
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        monocarboxylic acid 17618
                                          ciprofibrate 138
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