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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:immunological adjuvant
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Accession:CHEBI:50847 term browser browse the term
Definition:A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
Synonyms:related_synonym: Immunoactivator;   Immunoadjuvant;   Immunologic adjuvant;   Immunopotentiator;   Immunostimulant
 alt_id: MESH:D000276
 xref_mesh: MESH:D000276
 xref: Wikipedia:Immunologic_adjuvant



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immunological adjuvant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 increases expression ISO Adjuvants, Immunologic results in increased expression of BRD4 mRNA CTD PMID:25656449 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
JBrowse link
G Casp1 caspase 1 increases secretion
multiple interactions
ISO Adjuvants, Immunologic results in increased secretion of CASP1 protein modified form
[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased activity of and results in increased cleavage of CASP1 protein; [Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of CASP1 protein modified form; Adjuvants, Immunologic results in increased activity of and results in increased cleavage of CASP1 protein; CASP1 protein affects the reaction [[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein]
CTD PMID:17404311 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cat catalase multiple interactions EXP [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in decreased activity of CAT protein; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in decreased activity of CAT protein] CTD PMID:27028940 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd4 Cd4 molecule affects response to substance ISO CD4 protein affects the susceptibility to Adjuvants, Immunologic CTD PMID:11160013 NCBI chr 4:157,668,878...157,695,366 JBrowse link
G Cd40 CD40 molecule increases expression ISO Adjuvants, Immunologic results in increased expression of CD40 protein CTD PMID:11160013 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd83 CD83 molecule increases expression ISO Adjuvants, Immunologic results in increased expression of CD83 protein CTD PMID:11160013 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule increases expression ISO Adjuvants, Immunologic results in increased expression of CD86 protein CTD PMID:11160013 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in decreased activity of CAT protein; [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of PTGS2 protein; [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of RELA protein; [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of TNF protein; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in decreased activity of CAT protein]; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of PTGS2 protein]; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of RELA protein]; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of TNF protein] CTD PMID:27028940 NCBI chr 7:129,098,489...129,127,620
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Adjuvants, Immunologic inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]
Adjuvants, Immunologic inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]; MYD88 protein affects the reaction [Adjuvants, Immunologic inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]]
CTD PMID:17404311 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Adjuvants, Immunologic results in increased expression of ICAM1 protein CTD PMID:11160013 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein; CASP1 protein affects the reaction [[Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein] CTD PMID:17404311 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Adjuvants, Immunologic co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form
[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL1B protein modified form; MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL1B protein modified form]
CTD PMID:17404311 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 affects response to substance
increases expression
ISO IL4 protein affects the susceptibility to Adjuvants, Immunologic
Adjuvants, Immunologic results in increased expression of IL4 mRNA
CTD PMID:11160013 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL6 protein; MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL6 protein] CTD PMID:17404311 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL1B protein modified form]; MYD88 protein affects the reaction [[K-12 lipopolysaccharide co-treated with Adjuvants, Immunologic] results in increased secretion of IL6 protein]; MYD88 protein affects the reaction [Adjuvants, Immunologic inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]] CTD PMID:17404311 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of PTGS2 protein; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of PTGS2 protein] CTD PMID:27028940 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of RELA protein; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of RELA protein] CTD PMID:27028940 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of TNF protein; Yohimbine inhibits the reaction [[COL2A1 protein co-treated with Adjuvants, Immunologic co-treated with Freund's Adjuvant] results in increased expression of TNF protein] CTD PMID:27028940 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO KRN 7000 results in increased expression of CXCL10 protein CTD PMID:15867097 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Il12b interleukin 12B increases expression ISO KRN 7000 results in increased expression of IL12B protein CTD PMID:15867097 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
6-hydroxymelatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO
EXP
Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of 6-hydroxymelatonin] CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
benfotiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GCLM mRNA]
benphothiamine metabolite results in increased expression of GCLM mRNA; benphothiamine results in increased expression of GCLM mRNA
CTD PMID:29860433 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GSR mRNA] CTD PMID:29860433 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO benphothiamine metabolite results in increased expression of HMOX1 mRNA; benphothiamine results in increased expression of HMOX1 mRNA
benphothiamine inhibits the reaction [MAPT protein results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of HMOX1 mRNA]
CTD PMID:29860433 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of IL1B protein CTD PMID:29860433 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapt microtubule-associated protein tau decreases phosphorylation
multiple interactions
ISO benphothiamine results in decreased phosphorylation of MAPT protein
[benphothiamine co-treated with MAPT protein] results in decreased expression of IL1B protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of NOS2 protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of PTGS2 protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of RELA protein; [benphothiamine co-treated with MAPT protein] results in decreased expression of TNF protein; [benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA; [benphothiamine co-treated with MAPT protein] results in increased expression of TXN mRNA; benphothiamine inhibits the reaction [MAPT protein results in decreased activity of TKT protein]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of NOS2 mRNA]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of PPARGC1A protein]; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of SOD1 protein]; benphothiamine inhibits the reaction [MAPT protein results in increased expression of HMOX1 mRNA]
CTD PMID:29860433 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA] CTD PMID:29860433 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of NOS2 protein; benphothiamine inhibits the reaction [MAPT protein results in decreased expression of NOS2 mRNA] CTD PMID:29860433 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO benphothiamine metabolite results in increased expression of NQO1 mRNA; benphothiamine results in increased expression of NQO1 mRNA
[benphothiamine co-treated with MAPT protein] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [benphothiamine metabolite results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [benphothiamine results in increased expression of NQO1 mRNA]
CTD PMID:29860433 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO benphothiamine inhibits the reaction [MAPT protein results in decreased expression of PPARGC1A protein] CTD PMID:29860433 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of PTGS2 protein CTD PMID:29860433 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of RELA protein CTD PMID:29860433 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO benphothiamine inhibits the reaction [MAPT protein results in decreased expression of SOD1 protein] CTD PMID:29860433 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tkt transketolase multiple interactions EXP
ISO
[benphothiamine co-treated with Streptozocin] results in increased activity of TKT protein
benphothiamine inhibits the reaction [MAPT protein results in decreased activity of TKT protein]
CTD PMID:12592403 PMID:29860433 NCBI chr16:5,723,764...5,748,702
Ensembl chr16:5,723,762...5,748,698
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in decreased expression of TNF protein CTD PMID:29860433 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [benphothiamine co-treated with MAPT protein] results in increased expression of TXN mRNA CTD PMID:29860433 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
levamisole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
decreases activity
increases response to substance
ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ALPL protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ALPL mRNA]
Levamisole results in decreased activity of ALPL protein
ALPL gene mutant form results in increased susceptibility to Levamisole
[ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA
CTD PMID:18500657 PMID:27466191 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Atg5 autophagy related 5 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein] CTD PMID:32151603 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG7 protein] CTD PMID:32151603 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Levamisole results in increased expression of BAK1 protein CTD PMID:11139434 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Levamisole results in decreased expression of BCL2 protein CTD PMID:11139434 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of BECN1 protein] CTD PMID:32151603 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Cldn1 claudin 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of CLDN1 protein] CTD PMID:32151603 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Clu clusterin decreases expression ISO Levamisole results in decreased expression of CLU mRNA CTD PMID:11139434 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Dcc DCC netrin 1 receptor multiple interactions ISO DCC protein results in increased susceptibility to [Fluorouracil co-treated with Levamisole] CTD PMID:15148649 NCBI chr18:64,868,987...65,972,783
Ensembl chr18:64,873,898...65,972,740
JBrowse link
G Edn1 endothelin 1 decreases expression ISO Levamisole results in decreased expression of EDN1 mRNA CTD PMID:11139434 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]; Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA] CTD PMID:18500657 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [ALPL gene mutant form results in increased susceptibility to Levamisole] which results in increased expression of FOS mRNA CTD PMID:27466191 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of FOXP3 protein] CTD PMID:32151603 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of GATA3 protein] CTD PMID:32151603 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO
EXP
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IFNG mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IFNG protein]
Levamisole results in increased expression of IFNG mRNA; Levamisole results in increased expression of IFNG protein
CTD PMID:10886398 PMID:23395935 PMID:32151603 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il15 interleukin 15 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL15 protein] CTD PMID:23395935 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL17A protein] CTD PMID:32151603 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL1B protein] CTD PMID:32151603 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein] CTD PMID:23395935 PMID:32151603 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il21 interleukin 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL21 protein] CTD PMID:32151603 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL23A protein]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL23A protein] CTD PMID:23395935 PMID:32151603 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
EXP
ISO
Levamisole inhibits the reaction [Mercuric Chloride results in increased expression of IL4 mRNA]
Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL4 protein]
Levamisole results in decreased expression of IL4 mRNA
CTD PMID:10886398 PMID:32151603 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL6 protein] CTD PMID:23395935 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO Levamisole results in decreased expression of NOS3 protein CTD PMID:11139434 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked multiple interactions ISO Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of PHEX mRNA] CTD PMID:18500657 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Levamisole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:15047127 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Levamisole results in decreased expression of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Levamisole inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein] CTD PMID:15047127 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of RORC protein] CTD PMID:32151603 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TBX21 protein] CTD PMID:32151603 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TGFB3 protein] CTD PMID:32151603 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TJP1 protein] CTD PMID:32151603 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR2 mRNA] CTD PMID:32151603 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr6 toll-like receptor 6 multiple interactions ISO Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of TLR6 mRNA] CTD PMID:32151603 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Levamisole results in decreased expression of TNF protein CTD PMID:17397355 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Levamisole results in decreased expression of TP53 mRNA; Levamisole results in decreased expression of TP53 protein CTD PMID:11139434 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
melatonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in decreased expression of ABCB1 protein] CTD PMID:28223141 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 multiple interactions
decreases metabolic processing
ISO [ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
ABCB6 gene mutant form results in decreased metabolism of Melatonin
CTD PMID:25623066 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acan aggrecan increases expression ISO Melatonin results in increased expression of ACAN mRNA CTD PMID:20738756 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627
JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of ACHE]; Melatonin inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Melatonin inhibits the reaction [Dexamethasone results in increased activity of ACHE protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of ACHE protein]; Melatonin inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:19705549 PMID:21986892 PMID:22013727 PMID:30372842 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:26882442 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Melatonin results in decreased expression of ADIPOQ mRNA CTD PMID:20738756 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adora2b adenosine A2B receptor multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of ADORA2B mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of ADORA2B mRNA]
Melatonin results in decreased expression of ADORA2B mRNA
CTD PMID:21461237 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of AGER protein] CTD PMID:29763682 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen decreases expression EXP Melatonin results in decreased expression of AGT protein CTD PMID:19018803 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of AKR7A3 mRNA] CTD PMID:20033131 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
Melatonin results in increased phosphorylation of AKT1 protein
Melatonin inhibits the reaction [cyfluthrin results in increased expression of AKT1 mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of AKT1 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]
CTD PMID:18078454 PMID:21138475 PMID:22225513 PMID:23374533 PMID:23963992 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions ISO Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein] CTD PMID:24523661 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alb albumin multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in decreased expression of ALB protein] CTD PMID:16652224 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA] CTD PMID:23963992 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Melatonin results in increased expression of ALPL mRNA CTD PMID:20738756 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Aox1 aldehyde oxidase 1 multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of AOX1 mRNA] CTD PMID:31330490 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases expression
ISO
EXP
Melatonin affects the reaction [APP protein binds to APP protein]; Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form]
Melatonin inhibits the reaction [[Aluminum Chloride results in increased expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)]; Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein]
Melatonin analog results in decreased expression of APP protein; Melatonin results in decreased expression of APP protein
CTD PMID:10617124 PMID:18231852 PMID:18537544 PMID:33130240 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
EXP [Melatonin co-treated with Ethanol] results in increased expression of AR protein; Ethanol inhibits the reaction [Melatonin results in increased expression of AR protein] CTD PMID:23591044 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like multiple interactions EXP Melatonin affects the reaction [Rotenone affects the expression of ARNTL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of ARNTL] CTD PMID:23085516 PMID:25430725 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Astl astacin like metalloendopeptidase multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in decreased expression of and affects the localization of ASTL protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of and affects the localization of ASTL protein] CTD PMID:28178360 PMID:31931096 NCBI chr 3:114,563,135...114,580,295
Ensembl chr 3:114,563,135...114,578,868
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein modified form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF2 protein] CTD PMID:23591579 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP Melatonin inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein] CTD PMID:17645694 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased expression of ATF6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of ATF6 protein] CTD PMID:18715270 PMID:28070110 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atp6v1c1 ATPase H+ transporting V1 subunit C1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278
JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of BACE1 protein] CTD PMID:33130240 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases phosphorylation
ISO Melatonin promotes the reaction [YWHAB protein binds to BAD protein]
Melatonin results in increased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]; Melatonin inhibits the reaction [sodium arsenite results in increased phosphorylation of BAD protein]
CTD PMID:18078454 PMID:21138475 PMID:29763682 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO
EXP
[Melatonin co-treated with Tretinoin] results in increased expression of BAK1 protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
Melatonin inhibits the reaction [Indomethacin results in increased expression of BAK1 mRNA]
CTD PMID:10965999 PMID:19220725 PMID:23963992 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of BAX protein
Melatonin results in increased expression of BAX mRNA
Melatonin inhibits the reaction [Gentamicins results in increased expression of BAX protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; Melatonin inhibits the reaction [Indomethacin affects the localization of BAX protein]; Melatonin inhibits the reaction [Indomethacin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [Methionine results in increased expression of BAX protein]
Melatonin results in increased expression of BAX protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]
[Doxorubicin co-treated with Melatonin] results in increased expression of BAX protein; [Melatonin co-treated with Tretinoin] results in increased expression of BAX protein; [Tretinoin co-treated with Melatonin] results in increased expression of BAX protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [BAX protein binds to BAX protein]; Melatonin inhibits the reaction [Cisplatin affects the expression of BAX protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of BAX mRNA]; Melatonin promotes the reaction [BID protein binds to BAX protein]; Melatonin results in increased activity of and results in increased expression of BAX protein
Melatonin results in increased expression of BAX mRNA; Melatonin results in increased expression of BAX protein
CTD PMID:9649124 PMID:10965999 PMID:14690559 PMID:15683462 PMID:15964511 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases expression
affects localization
ISO
EXP
[Doxorubicin co-treated with Melatonin] results in decreased expression of BCL2 protein; [Melatonin co-treated with Tretinoin] results in decreased expression of BCL2 protein; [Tretinoin co-treated with Melatonin] results in decreased expression of BCL2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Cisplatin affects the expression of BCL2 protein]; Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2 protein]
Melatonin results in decreased expression of BCL2 mRNA; Melatonin results in decreased expression of BCL2 protein
[Puromycin Aminonucleoside co-treated with Melatonin] results in increased expression of BCL2 protein; Melatonin inhibits the reaction [decamethrin results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Methionine results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of BCL2 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of BCL2 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]
Melatonin results in increased expression of BCL2 protein
Melatonin affects the localization of BCL2 protein
CTD PMID:9649124 PMID:10965999 PMID:12220328 PMID:14690559 PMID:14993511 More... NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Indomethacin results in decreased expression of BCL2L1 mRNA]
Melatonin promotes the reaction [Puromycin results in decreased expression of BCL2L1 protein]
CTD PMID:19220725 PMID:21244482 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO
EXP
Melatonin inhibits the reaction [Scopolamine results in decreased expression of BDNF protein]
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Dietary Fats results in decreased expression of BDNF mRNA]; Melatonin inhibits the reaction [Ethanol results in decreased expression of BDNF mRNA]
CTD PMID:29476728 PMID:30372842 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Cisplatin inhibits the reaction [Melatonin results in increased expression of BECN1 protein] CTD PMID:24799992 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO Melatonin results in increased expression of BGLAP mRNA CTD PMID:20738756 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
ISO Melatonin promotes the reaction [BID protein binds to BAX protein]
Melatonin results in increased expression of BID protein
CTD PMID:19552762 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of BIRC5 mRNA
[Doxorubicin co-treated with Melatonin] results in decreased expression of BIRC5 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of BIRC5 mRNA]
CTD PMID:33507000 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of BNIP3 mRNA] CTD PMID:31330490 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Btg2 BTG anti-proliferation factor 2 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of BTG2 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of BTG2 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]
CTD PMID:28095641 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Calm1 calmodulin 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Capn1 calpain 1 multiple interactions EXP Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CAPN1 mRNA] CTD PMID:30372842 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP1 protein
CTD PMID:23963992 PMID:25903262 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions EXP
ISO
[Melatonin co-treated with Aluminum Chloride] results in decreased expression of CASP12 protein; Melatonin inhibits the reaction [Methamphetamine results in increased cleavage of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased expression of CASP12 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP12 protein]
Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP12 protein]
CTD PMID:17645694 PMID:18715270 PMID:28070110 PMID:30910607 PMID:33130240 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
decreases expression
ISO
EXP
[Doxorubicin co-treated with Melatonin] results in increased expression of CASP3 protein; [essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of CASP3 protein; Melatonin inhibits the reaction [cyfluthrin results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin promotes the reaction [flavone results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin promotes the reaction [Puromycin results in increased activity of CASP3 protein]
Melatonin results in increased expression of CASP3 protein
Melatonin results in decreased activity of CASP3 protein
Melatonin results in increased activity of CASP3 protein
Melatonin results in decreased expression of CASP3 protein
[Melatonin co-treated with Thioacetamide] results in increased expression of CASP3 protein; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; Melatonin inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]
Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Radon results in increased cleavage of CASP3 protein]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
CTD PMID:12220328 PMID:12880480 PMID:15683462 PMID:15800915 PMID:15964511 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO
EXP
Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]
Melatonin inhibits the reaction [bisphenol A results in increased activity of CASP8 protein]
Melatonin results in increased activity of CASP8 protein
CTD PMID:19012662 PMID:21431366 PMID:25454643 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [Dibutyl Phthalate results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of CASP9 protein]
Melatonin results in increased activity of CASP9 protein
Melatonin inhibits the reaction [Indomethacin results in increased activity of CASP9 protein]
CTD PMID:19012662 PMID:19220725 PMID:19552762 PMID:20130848 PMID:20964710 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases activity
increases expression
decreases activity
ISO
EXP
[aluminum lactate co-treated with Melatonin] results in increased expression of CAT mRNA; [Melatonin co-treated with Pentoxifylline] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; luzindole inhibits the reaction [Melatonin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Arsenic Trioxide results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CAT mRNA]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Urethane results in increased expression of CAT protein]
Melatonin results in increased expression of CAT mRNA
[Melatonin co-treated with cyfluthrin] results in increased activity of CAT protein; Melatonin inhibits the reaction [cyfluthrin results in decreased activity of CAT protein]
Melatonin results in decreased activity of CAT protein
[aluminum lactate co-treated with Melatonin] results in increased activity of CAT mRNA; [aluminum lactate co-treated with Melatonin] results in increased activity of CAT protein; [Melatonin co-treated with aluminum lactate] results in increased expression of CAT mRNA; [Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [aluminum lactate results in increased activity of CAT protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of CAT]; Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of CAT protein]; Melatonin inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Propoxur results in decreased activity of CAT protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:9194422 PMID:12500499 PMID:12823611 PMID:15589378 PMID:16098089 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin increases secretion EXP Melatonin results in increased secretion of CCK protein CTD PMID:15009505 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:22225513 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of CCL5 mRNA]
CTD PMID:22225513 PMID:31330490 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Melatonin results in decreased expression of CCNB1 mRNA; Melatonin results in decreased expression of CCNB1 protein CTD PMID:21108658 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Melatonin results in decreased expression of CCND1 mRNA; Melatonin results in decreased expression of CCND1 protein CTD PMID:21108658 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd14 CD14 molecule multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of CD14 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd200 Cd200 molecule decreases expression ISO Melatonin results in decreased expression of CD200 protein CTD PMID:27503577 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cd36 CD36 molecule multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CD36 mRNA] CTD PMID:21689150 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Melatonin results in decreased expression of CDK1 mRNA; Melatonin results in decreased expression of CDK1 protein CTD PMID:21108658 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Melatonin results in decreased expression of CDK4 mRNA; Melatonin results in decreased expression of CDK4 protein CTD PMID:21108658 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Melatonin results in increased expression of CDKN1A protein
Melatonin inhibits the reaction [bisphenol A results in decreased expression of CDKN1A protein]; Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
CTD PMID:12071473 PMID:18384530 PMID:29330934 PMID:29734669 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CISH mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CISH mRNA]
Melatonin results in decreased expression of CISH mRNA
CTD PMID:21461237 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Melatonin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased activity of CKB protein] CTD PMID:19389042 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Clec4a C-type lectin domain family 4, member A multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC4N mRNA]
Melatonin results in decreased expression of CLEC4N mRNA
CTD PMID:21461237 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
JBrowse link
G Clock clock circadian regulator multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride affects the expression of CLOCK] CTD PMID:23085516 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Colec12 collectin sub-family member 12 multiple interactions ISO [Lipopolysaccharides co-treated with Melatonin] results in increased expression of COLEC12 mRNA CTD PMID:21461237 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO Melatonin inhibits the reaction [Dibutyl Phthalate results in decreased expression of COX4I1 protein] CTD PMID:30910607 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA] CTD PMID:23963992 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cry1 cryptochrome circadian regulator 1 multiple interactions EXP Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY1]; Melatonin affects the reaction [Rotenone affects the expression of CRY1 mRNA] CTD PMID:23085516 PMID:25430725 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Cry2 cryptochrome circadian regulator 2 affects expression
multiple interactions
EXP Melatonin affects the expression of CRY2 mRNA
Melatonin affects the reaction [Cadmium Chloride affects the expression of CRY2]; Melatonin affects the reaction [Rotenone affects the expression of CRY2 mRNA]
CTD PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]] CTD PMID:26990689 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsb cathepsin B multiple interactions ISO Melatonin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CTSB protein] CTD PMID:21392095 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions ISO Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of CTSD] CTD PMID:22041583 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
decreases expression
ISO [Lipopolysaccharides co-treated with Melatonin] results in decreased expression of CXCL10 mRNA; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]
Melatonin results in decreased expression of CXCL10 mRNA
CTD PMID:21461237 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of CYBB mRNA] CTD PMID:31330490 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression
decreases activity
ISO
EXP
Melatonin results in decreased expression of CYP19A1
Melatonin results in decreased activity of CYP19A1 protein
CTD PMID:16080194 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation
EXP
ISO
Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP1A1 mRNA]
Melatonin results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of Melatonin
CTD PMID:15616152 PMID:19919601 PMID:20033131 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation
multiple interactions
increases metabolic processing
increases hydroxylation
affects metabolic processing
decreases activity
ISO
EXP
CYP1A2 protein results in decreased methylation of Melatonin
[ABCB6 gene mutant form results in decreased expression of CYP1A2 mRNA] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]; [ABCB6 gene mutant form results in decreased expression of CYP1A2 protein] inhibits the reaction [CYP1A2 protein results in increased metabolism of Melatonin]
CYP1A2 protein results in increased hydroxylation of Melatonin
CYP1A2 protein affects the metabolism of Melatonin
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of CYP1A2 mRNA
Melatonin results in decreased activity of CYP1A2 protein
Melatonin inhibits the reaction [CYP1A2 protein results in increased hydrolysis of Benzo(a)pyrene]
CTD PMID:15616152 PMID:15626586 PMID:15824912 PMID:17565714 PMID:19919601 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity
increases hydroxylation
ISO 2,4,3',5'-tetramethoxystilbene inhibits the reaction [CYP1B1 protein results in increased hydroxylation of Melatonin]
Melatonin results in decreased activity of CYP1B1 protein
CTD PMID:15616152 PMID:19919601 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions ISO Melatonin inhibits the reaction [Ethanol results in increased expression of CYP27A1 mRNA] CTD PMID:28095641 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of CYP2B2 mRNA] CTD PMID:20033131 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation
decreases methylation
ISO CYP2C19 protein results in increased hydroxylation of Melatonin
CYP2C19 protein results in decreased methylation of Melatonin
CTD PMID:15616152 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Benzene results in increased activity of CYP2E1 protein]
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
CTD PMID:20338863 PMID:20964710 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of CYP7A1 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of CYP7A1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]
CTD PMID:28095641 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO Melatonin inhibits the reaction [Ethanol results in increased expression of CYP8B1 mRNA] CTD PMID:28095641 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dap3 death associated protein 3 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of DDIT3 protein] CTD PMID:18715270 PMID:28070110 PMID:33130240 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein increases expression
multiple interactions
ISO Melatonin results in increased expression of DIABLO mRNA; Melatonin results in increased expression of DIABLO protein
[Doxorubicin co-treated with Melatonin] results in increased expression of DIABLO protein; Doxorubicin promotes the reaction [Melatonin results in increased expression of DIABLO mRNA]
CTD PMID:33507000 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of DNM1L protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]
Melatonin inhibits the reaction [Rotenone results in increased expression of DNM1L protein]
CTD PMID:26882442 PMID:29183837 PMID:29966675 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Melatonin inhibits the reaction [manganese chloride results in decreased expression of DRD1 protein] CTD PMID:24969583 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Rotenone results in increased expression of DRD2 protein]
Melatonin promotes the reaction [manganese chloride results in decreased expression of DRD2 protein]
CTD PMID:18289173 PMID:24969583 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased expression of EIF2AK3 protein modified form] CTD PMID:28070110 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2S1 protein] CTD PMID:28070110 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:19054297 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588
JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eno2 enolase 2 multiple interactions ISO Melatonin inhibits the reaction [manganese chloride results in decreased expression of ENO2 protein] CTD PMID:24969583 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit increases expression ISO Melatonin results in increased expression of ERCC1 protein CTD PMID:24799992 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased expression of ERN1 protein modified form]; Melatonin promotes the reaction [Cyclosporine results in increased expression of ERN1 protein] CTD PMID:20136702 PMID:28070110 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of ESR1 protein]; Melatonin inhibits the reaction [Cadmium results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to CTNNB1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Estradiol results in increased activity of ESR1 protein]]
Melatonin results in decreased expression of ESR1 mRNA
Melatonin results in decreased expression of ESR1 mRNA; Melatonin results in decreased expression of ESR1 protein
[Ethanol co-treated with Melatonin] results in decreased expression of ESR1 protein; [Ethanol co-treated with Melatonin] results in increased expression of ESR1 protein; Melatonin promotes the reaction [alitretinoin results in decreased expression of ESR1 mRNA]
CTD PMID:15813899 PMID:16030176 PMID:16051031 PMID:16635015 PMID:23591044 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
EXP [Melatonin co-treated with Ethanol] results in increased expression of ESR2 protein; Ethanol inhibits the reaction [Melatonin results in decreased expression of ESR2 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of ESR2 protein] CTD PMID:23591044 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Melatonin results in decreased expression of FABP4 mRNA CTD PMID:20738756 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [bisphenol A results in increased expression of FAS protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FAS protein]
Melatonin results in decreased expression of FAS mRNA; Melatonin results in decreased expression of FAS protein
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]
CTD PMID:14993511 PMID:20181888 PMID:23963992 PMID:25454643 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of FASLG protein] CTD PMID:14993511 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FASN mRNA] CTD PMID:21689150 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of FCGR2B mRNA]
Melatonin results in decreased expression of FCGR2B mRNA
CTD PMID:21461237 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fgf9 fibroblast growth factor 9 multiple interactions EXP Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 mRNA]; Melatonin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of FGF9 protein] CTD PMID:19476551 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in increased expression of FIS1 protein] CTD PMID:29966675 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Melatonin inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] CTD PMID:19524604 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Melatonin inhibits the reaction [Capsaicin results in increased expression of FOS protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of FOS protein] CTD PMID:19172228 PMID:28238930 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Melatonin inhibits the reaction [Ethanol results in decreased expression of FSHB protein] CTD PMID:23591044 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
EXP
ISO
Melatonin results in increased activity of G6PD protein
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of G6PD protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of G6PD protein
CTD PMID:16224550 PMID:25903262 PMID:29763682 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gap43 growth associated protein 43 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in decreased expression of GAP43 protein] CTD PMID:19409439 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
JBrowse link
G Gast gastrin multiple interactions
increases expression
EXP luzindole inhibits the reaction [Melatonin results in increased expression of GAST] CTD PMID:12074098 PMID:16207293 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]] CTD PMID:25550330 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]] CTD PMID:25550330 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP
ISO
Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]
Melatonin inhibits the reaction [manganese chloride results in increased expression of GFAP protein]
CTD PMID:17572393 PMID:25288107 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GGT1 protein] CTD PMID:15700767 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Melatonin co-treated with Thioacetamide] results in increased expression of GPT protein; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:15700767 PMID:26882442 PMID:31967703 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
EXP
ISO
[aluminum lactate co-treated with Melatonin] results in increased expression of GPX1 mRNA
Melatonin affects the reaction [manganese chloride results in decreased expression of GPX1 protein]
Melatonin results in increased expression of GPX1 mRNA
CTD PMID:15589378 PMID:25288107 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GPX2 mRNA CTD PMID:20033131 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grb2 growth factor receptor bound protein 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form] CTD PMID:15842767 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases activity
decreases expression
EXP
ISO
[Cadmium Chloride co-treated with Melatonin] results in decreased expression of GSR mRNA; aluminum lactate affects the reaction [Melatonin results in increased activity of GSR protein]; Melatonin inhibits the reaction [Gentamicins results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased activity of GSR protein]
[essential 303 forte co-treated with Silymarin co-treated with Melatonin analog] affects the activity of GSR protein
Melatonin results in decreased expression of GSR protein
[aluminum lactate co-treated with Melatonin] results in increased expression of GSR mRNA; aluminum lactate promotes the reaction [Melatonin results in decreased expression of GSR protein]; luzindole inhibits the reaction [Melatonin results in increased activity of GSR protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of GSR protein]; Melatonin inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; Melatonin promotes the reaction [aluminum lactate results in decreased expression of GSR protein]
Melatonin results in decreased expression of GSR mRNA
CTD PMID:12823611 PMID:16098089 PMID:16224550 PMID:16931443 PMID:19405147 More... NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [Melatonin co-treated with oxfendazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:20033131 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP [Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of GSTM1 mRNA CTD PMID:20033131 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]
Melatonin affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA]
CTD PMID:21986892 PMID:23963992 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of HAVCR1 protein] CTD PMID:29763682 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone affects the localization of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased acetylation of and results in increased phosphorylation of HMGB1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased secretion of HMGB1 protein] CTD PMID:27413111 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
EXP
ISO
Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein]; Melatonin inhibits the reaction [Ethanol results in decreased expression of HMOX1 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein; Melatonin inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]
Melatonin results in increased expression of HMOX1 protein
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
Melatonin results in decreased expression of HMOX1 mRNA
CTD PMID:10942521 PMID:12420312 PMID:16948784 PMID:17645694 PMID:18715270 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
decreases expression
EXP [Cadmium Chloride co-treated with Melatonin] results in decreased expression of HMOX2 mRNA; Melatonin affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA]
Melatonin results in decreased expression of HMOX2 mRNA
CTD PMID:21442002 PMID:21986892 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:23963992 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in increased expression of HSPA1A mRNA] CTD PMID:31330490
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Cyclosporine results in increased expression of HSPA5 protein]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 mRNA]; Melatonin promotes the reaction [Methamphetamine results in increased expression of HSPA5 protein] CTD PMID:20136702 PMID:28070110 PMID:33130240 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP Melatonin affects the reaction [Mercuric Chloride results in increased expression of HSPA9 protein] CTD PMID:16801527 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IFNG protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG mRNA]
CTD PMID:16373423 PMID:23374533 PMID:23963992 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL10 protein] CTD PMID:16373423 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]
Melatonin results in decreased expression of IL1A mRNA
CTD PMID:21461237 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
ISO
EXP
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]
Melatonin results in decreased secretion of IL1B protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL1B protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL1B protein]
Melatonin results in decreased expression of IL1B mRNA
CTD PMID:15714805 PMID:16373423 PMID:19028472 PMID:20374443 PMID:21461237 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases activity
multiple interactions
ISO Melatonin results in increased activity of IL2 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL2 protein]
CTD PMID:9730580 PMID:16373423 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases secretion
EXP
ISO
Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of IL6 protein]
Melatonin results in decreased secretion of IL6 protein
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of IL6 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]
CTD PMID:16373423 PMID:20374443 PMID:21158907 PMID:27413111 PMID:28238930 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor multiple interactions EXP Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein] CTD PMID:19705549 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in decreased expression of IRS1 protein] CTD PMID:29763682 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Izumo1r IZUMO1 receptor, JUNO multiple interactions ISO Melatonin inhibits the reaction [bisphenol A affects the expression of and affects the localization of IZUMO1R protein]; Melatonin inhibits the reaction [Ethinyl Estradiol affects the localization of IZUMO1R protein] CTD PMID:28178360 PMID:31931096 NCBI chr 8:11,744,383...11,746,872
Ensembl chr 8:11,725,863...11,748,465
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and affects the localization of JUN protein] CTD PMID:28238930 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of KEAP1 protein
Melatonin affects the reaction [manganese chloride affects the expression of KEAP1 protein]
CTD PMID:25288107 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kl Klotho multiple interactions ISO 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; 4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLC mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased expression of GCLM mRNA]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]] CTD PMID:25550330 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of LAMP2 protein] CTD PMID:26882442 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lep leptin decreases expression ISO
EXP
Melatonin results in decreased expression of LEP mRNA
Melatonin results in decreased expression of LEP protein
CTD PMID:19028472 PMID:20738756 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP [Melatonin co-treated with LHB protein] results in increased chemical synthesis of Testosterone; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of LHB] CTD PMID:16054318 PMID:23085516 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO Melatonin results in decreased expression of LPL mRNA CTD PMID:20738756 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of LRP1 protein] CTD PMID:33130240 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Ly96 lymphocyte antigen 96 multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of LY96 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of LY96 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:27413111 PMID:28238930 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Melatonin inhibits the reaction [Radon results in increased expression of MAP1LC3B protein] CTD PMID:33107683 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK1 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK1 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK1 protein]]
CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Melatonin results in increased expression of MAPK10 protein CTD PMID:19012662 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Nicotine results in decreased expression of MAPK3 protein]; Melatonin inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased phosphorylation of MAPK3 protein]
Melatonin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]; Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form results in decreased phosphorylation of MAPK3 protein]]
CTD PMID:20050989 PMID:25550330 PMID:28238930 PMID:29330934 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Melatonin results in increased expression of MAPK8 protein CTD PMID:19012662 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Melatonin results in increased expression of MAPK9 protein CTD PMID:19012662 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Melatonin inhibits the reaction [Wortmannin results in increased phosphorylation of MAPT protein]
Melatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]
Melatonin inhibits the reaction [Mercuric Chloride results in increased phosphorylation of MAPT protein]
CTD PMID:10617124 PMID:15842767 PMID:23963992 PMID:31833155 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mbp myelin basic protein multiple interactions ISO Melatonin inhibits the reaction [Scopolamine results in decreased expression of MBP protein] CTD PMID:29476728 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO Melatonin inhibits the reaction [oxaliplatin results in decreased expression of MCL1 protein] CTD PMID:20626587 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA] CTD PMID:20033131 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mfn1 mitofusin 1 multiple interactions EXP [Doxorubicin results in increased susceptibility to Melatonin] which results in increased expression of MFN1 protein; [Melatonin results in increased susceptibility to Doxorubicin] which results in increased expression of MFN1 protein CTD PMID:29966675 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN2 protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of MFN2 protein] CTD PMID:26882442 PMID:29966675 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mir497 microRNA 497 multiple interactions
increases expression
ISO MIR497 mRNA affects the reaction [Melatonin results in decreased expression of BTG2 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of CYP7A1 mRNA]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]
Melatonin results in increased expression of MIR497 mRNA
CTD PMID:28095641 NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MKI67 protein]
Melatonin results in decreased expression of MKI67 mRNA; Melatonin results in decreased expression of MKI67 protein
CTD PMID:19028472 PMID:21062352 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Melatonin inhibits the reaction [Aluminum Chloride results in decreased expression of MME protein] CTD PMID:33130240 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions EXP Melatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein]
Melatonin results in decreased expression of MMP2 mRNA; Melatonin results in decreased expression of MMP2 protein
[Doxorubicin co-treated with Melatonin] results in decreased expression of MMP2 protein; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP2 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in increased expression of MMP2 protein]
CTD PMID:16150113 PMID:16934674 PMID:29763682 PMID:33507000 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [Indomethacin results in increased expression of and results in increased secretion of MMP9 protein]
Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 mRNA]; Doxorubicin promotes the reaction [Melatonin results in decreased expression of MMP9 protein]
Melatonin results in decreased expression of MMP9 mRNA; Melatonin results in decreased expression of MMP9 protein
CTD PMID:16150113 PMID:33507000 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP Melatonin promotes the reaction [lead acetate results in increased expression of MT1A mRNA] CTD PMID:25601058 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A multiple interactions EXP Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA] CTD PMID:25601058 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding
increases expression
multiple interactions
ISO
EXP
Melatonin analog binds to MTNR1A protein; Melatonin binds to MTNR1A protein
Melatonin results in increased expression of MTNR1A protein
Carbaryl inhibits the reaction [Melatonin binds to MTNR1A protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1A protein]
[Ethanol co-treated with Melatonin] results in increased expression of MTNR1A protein; luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1A protein]
CTD PMID:11063602 PMID:17645693 PMID:20399199 PMID:23591044 PMID:28027439 More... NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
JBrowse link
G Mtnr1b melatonin receptor 1B multiple interactions
increases expression
affects binding
ISO
EXP
[luzindole binds to and results in decreased activity of MTNR1B protein] which results in decreased susceptibility to Melatonin
luzindole inhibits the reaction [Melatonin results in increased expression of MTNR1B protein]
Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]; Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]; Guanosine Triphosphate inhibits the reaction [Carbaryl inhibits the reaction [Melatonin binds to MTNR1B protein]]; Guanosine Triphosphate inhibits the reaction [Carbofuran inhibits the reaction [Melatonin binds to MTNR1B protein]]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
Melatonin analog binds to MTNR1B protein; Melatonin binds to MTNR1B protein
CTD PMID:11063602 PMID:11270484 PMID:16030176 PMID:17645693 PMID:20399199 More... NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases phosphorylation
increases activity
ISO Cisplatin affects the reaction [Melatonin results in increased phosphorylation of MTOR protein]; Melatonin promotes the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Melatonin results in increased activity of MTOR protein
CTD PMID:19054297 PMID:24799992 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of MYD88 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:28238930 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA1 protein] CTD PMID:29330934 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased expression of NCOA3 protein] CTD PMID:29330934 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase affects response to substance
multiple interactions
decreases expression
ISO [NEDD4 protein affects the susceptibility to Oxygen deficiency] which affects the susceptibility to Melatonin
Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of NEDD4 protein]; Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein]; Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein]; Melatonin promotes the reaction [Cycloheximide results in decreased expression of NEDD4 protein]; Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein]
Melatonin results in decreased expression of NEDD4 protein
CTD PMID:31325559 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
JBrowse link
G Nefh neurofilament heavy chain decreases phosphorylation ISO Melatonin analog results in decreased phosphorylation of NEFH protein; Melatonin results in decreased phosphorylation of NEFH protein CTD PMID:18231852 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nes nestin decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of NES protein
Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]
CTD PMID:16369854 PMID:17572393 PMID:21269327 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
EXP
ISO
Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in decreased expression of NFE2L2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NFE2L2 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NFE2L2 mRNA]
4-phenyl-2-propionamidotetraline inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]; [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein; Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]; Melatonin inhibits the reaction [manganese chloride results in increased expression of NFE2L2 protein]; SL 327 inhibits the reaction [Melatonin inhibits the reaction [KL mutant form affects the localization of and results in decreased activity of NFE2L2 protein]]
Melatonin results in increased expression of NFE2L2 protein
CTD PMID:20433640 PMID:25288107 PMID:25550330 PMID:27871981 PMID:30372842 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of NFKB1 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NFKB1 mRNA]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of and results in increased activity of NFKB1 protein]
CTD PMID:19028472 PMID:21158907 PMID:23963992 PMID:30372842 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein]]; Melatonin inhibits the reaction [Methamphetamine results in increased degradation of NFKBIA protein] CTD PMID:26283214 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
EXP Melatonin affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of NOS1 mRNA]; Melatonin inhibits the reaction [Cadmium results in increased expression of NOS1 mRNA]
Melatonin results in decreased expression of NOS1 mRNA
CTD PMID:16948784 PMID:21442002 PMID:21986892 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
decreases expression
ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of NOS2 mRNA]
Melatonin results in increased expression of NOS2 mRNA
Melatonin results in decreased expression of NOS2 mRNA
Melatonin affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA]; Melatonin affects the reaction [Mercuric Chloride results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Dietary Fats co-treated with Ethanol] results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Amphetamine results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of NOS2 mRNA]; Melatonin inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of NOS2 mRNA]; Melatonin inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]
CTD PMID:12074098 PMID:16801527 PMID:16948784 PMID:18524487 PMID:21442002 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 mRNA]; Melatonin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]; Melatonin promotes the reaction [Atorvastatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NOS3 protein]] CTD PMID:21585521 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Npm1 nucleophosmin 1 multiple interactions ISO Melatonin inhibits the reaction [NPM1 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Melatonin inhibits the reaction [Triiodothyronine, Reverse results in increased expression of NPPB mRNA] CTD PMID:17198541 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
EXP
ISO
[Diethylnitrosamine co-treated with oxfendazole co-treated with Melatonin] results in increased expression of NQO1 mRNA; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein]
Melatonin inhibits the reaction [cyfluthrin results in decreased activity of NQO1 protein]; Melatonin inhibits the reaction [cyfluthrin results in increased expression of NQO1 mRNA]
Melatonin affects the reaction [manganese chloride affects the expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of NQO1 protein]
Melatonin results in increased expression of NQO1 protein
CTD PMID:20033131 PMID:20433640 PMID:24969583 PMID:25288107 PMID:27871981 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions
affects activity
ISO Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; Melatonin inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]
Melatonin affects the activity of NQO2 protein
CTD PMID:20399199 PMID:22289031 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1H3 protein] CTD PMID:21689150 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in decreased expression of NR1I2 mRNA] CTD PMID:15617534 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects localization
ISO
EXP
Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]; Melatonin promotes the reaction [Dexamethasone results in decreased expression of NR3C1 mRNA]; Pertussis Toxin inhibits the reaction [Melatonin inhibits the reaction [Dexamethasone results in increased activity of NR3C1 protein]]
Melatonin inhibits the reaction [Dexamethasone results in increased expression of NR3C1 mRNA]
Melatonin affects the localization of NR3C1 protein
CTD PMID:10463946 PMID:15813899 PMID:18395440 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of NRF1 protein] CTD PMID:26882442 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Melatonin inhibits the reaction [Scopolamine results in decreased expression of NTRK2 protein] CTD PMID:23963992 PMID:29476728 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP Melatonin inhibits the reaction [Doxorubicin results in increased expression of PARP1 protein modified form] CTD PMID:29966675 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression EXP Melatonin results in decreased expression of PAWR protein CTD PMID:15964511 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
decreases expression
EXP
ISO
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PCNA protein]
Melatonin results in decreased expression of PCNA mRNA
CTD PMID:19028472 PMID:21062352 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde1b phosphodiesterase 1B multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Per1 period circadian regulator 1 multiple interactions EXP Melatonin affects the reaction [Cadmium Chloride affects the expression of PER1]; Melatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA] CTD PMID:17590544 PMID:21442002 PMID:23085516 PMID:25430725 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 multiple interactions
affects expression
EXP Melatonin affects the reaction [Rotenone affects the expression of PER2 mRNA]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER2 mRNA]
Melatonin affects the expression of PER2 mRNA
CTD PMID:17590544 PMID:21442002 PMID:25430725 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pf4 platelet factor 4 multiple interactions ISO [Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA CTD PMID:21461237 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pgr progesterone receptor multiple interactions
decreases expression
ISO
EXP
Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR]
Melatonin results in decreased expression of PGR protein alternative form
[Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form; [Ethanol co-treated with Melatonin] results in increased expression of PGR protein alternative form; Ethanol inhibits the reaction [Melatonin results in decreased expression of PGR protein alternative form]; Melatonin inhibits the reaction [Ethanol results in decreased expression of PGR protein alternative form]
CTD PMID:22041583 PMID:23591044 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PINK1 protein]; Melatonin inhibits the reaction [Doxorubicin results in increased expression of PINK1 protein] CTD PMID:26882442 PMID:29966675 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Pomc proopiomelanocortin multiple interactions
decreases response to substance
EXP
ISO
[Melatonin co-treated with p-Chloroamphetamine] results in increased expression of POMC protein
Melatonin inhibits the reaction [POMC protein results in increased abundance of Hydrocortisone]; Melatonin inhibits the reaction [POMC protein results in increased abundance of Progesterone]
Melatonin results in decreased susceptibility to POMC protein
CTD PMID:11478929 PMID:19301769 PMID:21332028 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of POU5F1 protein]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 mRNA]; Melatonin inhibits the reaction [Estradiol results in increased expression of POU5F1 protein]
Melatonin results in decreased expression of POU5F1 mRNA; Melatonin results in decreased expression of POU5F1 protein
CTD PMID:27551335 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
increases expression
multiple interactions
ISO Melatonin results in decreased expression of PPARG mRNA
Melatonin results in increased expression of PPARG protein
GW 1929 inhibits the reaction [Melatonin results in increased expression of PPARG protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PPARG protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PPARG protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PPARG protein]
CTD PMID:20738756 PMID:29734669 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO
EXP
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]; Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in increased acetylation of PPARGC1A protein]]
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Doxorubicin results in decreased expression of PPARGC1A protein]
CTD PMID:25159133 PMID:26882442 PMID:29966675 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PRKN protein] CTD PMID:26882442 NCBI chr 1:48,688,651...49,882,520 JBrowse link
G Prl prolactin multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL mRNA]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL protein]; Melatonin inhibits the reaction [Cadmium Chloride affects the expression of PRL] CTD PMID:23085516 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prnp prion protein increases expression
multiple interactions
ISO Melatonin results in increased expression of PRNP protein
GW 1929 inhibits the reaction [Melatonin results in increased expression of PRNP protein]; luzindole inhibits the reaction [Melatonin results in increased expression of PRNP protein]; Melatonin promotes the reaction [Pioglitazone results in increased expression of PRNP protein]; Pioglitazone promotes the reaction [Melatonin results in increased expression of PRNP protein]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in increased expression of CDKN1A protein]]]
CTD PMID:29734669 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Prom1 prominin 1 decreases expression
multiple interactions
ISO Melatonin results in decreased expression of PROM1 mRNA; Melatonin results in decreased expression of PROM1 protein
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2,4,6-trimethyl-N-(meta-3-trifluoromethylphenyl)benzenesulfonamide inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; 2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; N-caproylsphingosine affects the reaction [Melatonin results in decreased expression of PROM1 protein]; N-caproylsphingosine inhibits the reaction [Melatonin results in decreased expression of PROM1 mRNA]; TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein]
CTD PMID:30421542 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA] CTD PMID:23963992 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494
JBrowse link
G Psmd3 proteasome 26S subunit, non-ATPase 3 multiple interactions ISO [Oxygen deficiency co-treated with Melatonin] results in decreased expression of PSMD3 protein CTD PMID:31325559 NCBI chr10:83,643,473...83,655,620
Ensembl chr10:83,643,647...83,655,618
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [arsenic trioxide results in increased expression of PTGS2 protein]; Melatonin inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]
Melatonin inhibits the reaction [Radon results in decreased expression of PTGS2 mRNA]
CTD PMID:18588940 PMID:23376440 PMID:33107683 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rab7a RAB7A, member RAS oncogene family multiple interactions EXP Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of RAB7A protein] CTD PMID:26882442 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Melatonin co-treated with Tretinoin] results in increased activity of RARA protein; Melatonin promotes the reaction [Tretinoin results in increased activity of RARA protein] CTD PMID:10965999 PMID:15813899 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]]; Melatonin inhibits the reaction [Methamphetamine affects the localization of RELA protein]
Melatonin inhibits the reaction [Cyclophosphamide results in increased expression of RELA protein]; Melatonin inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]
CTD PMID:20433640 PMID:22225513 PMID:22526374 PMID:26283214 PMID:27871981 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Renbp renin binding protein multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of RENBP protein] CTD PMID:29763682 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516
JBrowse link
G Rgn regucalcin multiple interactions ISO Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]; Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]; Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]; PRNP protein promotes the reaction [Melatonin promotes the reaction [Pioglitazone inhibits the reaction [Indican results in decreased expression of RGN protein]]]; PRNP protein promotes the reaction [Pioglitazone promotes the reaction [Melatonin inhibits the reaction [Indican results in decreased expression of RGN protein]]] CTD PMID:29734669 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK1 protein] CTD PMID:29763682 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO
EXP
Melatonin inhibits the reaction [sodium arsenite results in increased expression of RIPK3 protein]
[Melatonin co-treated with Thioacetamide] results in increased expression of RIPK3 protein
CTD PMID:29763682 PMID:31967703 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rora RAR-related orphan receptor A affects binding ISO Melatonin binds to RORA protein CTD PMID:16030176 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Rpl19 ribosomal protein L19 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
JBrowse link
G Rpl23 ribosomal protein L23 multiple interactions ISO Melatonin inhibits the reaction [RPL23 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
JBrowse link
G Rpl3 ribosomal protein L3 multiple interactions ISO Melatonin inhibits the reaction [Oxygen deficiency results in increased expression of RPL3 protein] CTD PMID:31325559 NCBI chr 7:111,622,257...111,627,639
Ensembl chr 7:111,621,610...111,636,468
JBrowse link
G Rps19 ribosomal protein S19 multiple interactions ISO Melatonin inhibits the reaction [RPS19 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
JBrowse link
G Rps7 ribosomal protein S7 multiple interactions ISO Melatonin promotes the reaction [RPS7 protein binds to NEDD4 protein] CTD PMID:31325559 NCBI chr 6:45,266,200...45,271,064 JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO Melatonin results in increased expression of RUNX2 mRNA CTD PMID:20738756 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G S100g S100 calcium binding protein G increases expression
multiple interactions
EXP Melatonin results in increased expression of S100G mRNA; Melatonin results in increased expression of S100G protein
Hydrogen Peroxide promotes the reaction [Melatonin results in increased expression of S100G protein]
CTD PMID:20041988 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433
JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions
ISO
EXP
Melatonin results in decreased expression of SIRT1 protein
Melatonin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]
luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased activity of SIRT1 protein]]; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased activity of SIRT1 protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]; Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of and results in decreased activity of SIRT1 protein]]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium results in decreased expression of and results in decreased activity of SIRT1 protein]]
CTD PMID:21062352 PMID:25159133 PMID:29966675 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:20964710 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA]
Melatonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:21599003 PMID:23963992 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SLC2A4 mRNA]
Melatonin inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]
CTD PMID:17198541 PMID:29763682 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Rotenone results in decreased expression of SLC6A3 protein]
Melatonin inhibits the reaction [manganese chloride results in decreased expression of SLC6A3 protein]
CTD PMID:18289173 PMID:24969583 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Snca synuclein alpha multiple interactions EXP Melatonin inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Melatonin inhibits the reaction [sodium arsenite promotes the reaction [SNCA protein binds to SNCA protein]] CTD PMID:17645694 PMID:18289173 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases activity
increases expression
EXP
ISO
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; [Cadmium Chloride co-treated with Melatonin] results in increased expression of SOD1 mRNA; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD1 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased activity of and results in decreased expression of SOD1 protein]; Melatonin inhibits the reaction [Triiodothyronine, Reverse results in decreased expression of SOD1 mRNA]
Melatonin results in increased activity of SOD1 protein
Melatonin results in increased expression of SOD1 mRNA
[aluminum lactate co-treated with Melatonin] results in increased expression of SOD1 mRNA; luzindole inhibits the reaction [Melatonin results in increased activity of SOD1 protein]
CTD PMID:11523592 PMID:15589378 PMID:17198541 PMID:19405147 PMID:19680607 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases activity
increases expression
EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased activity of SOD2 protein]; Melatonin inhibits the reaction [isolevin results in increased expression of SOD2 protein]
luzindole inhibits the reaction [Melatonin results in increased activity of SOD2 protein]; Melatonin affects the reaction [manganese chloride results in decreased expression of SOD2 protein]
Melatonin results in increased expression of SOD2 mRNA
Melatonin inhibits the reaction [HMOX1 protein results in increased expression of SOD2 mRNA]
CTD PMID:10942521 PMID:11523592 PMID:15589378 PMID:16098089 PMID:20210856 More... NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP
ISO
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of SQSTM1 protein]
Melatonin inhibits the reaction [Radon results in increased expression of SQSTM1 protein]
Melatonin inhibits the reaction [cyfluthrin results in increased expression of SQSTM1 mRNA]
CTD PMID:26882442 PMID:31330490 PMID:33107683 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides affects the localization of SREBF1 protein] CTD PMID:21689150 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Melatonin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT1 protein]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:21158907 PMID:22225513 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases response to substance
increases phosphorylation
ISO
EXP
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
STAT3 protein results in increased susceptibility to Melatonin
Melatonin results in increased phosphorylation of STAT3 protein
Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of STAT3 protein]
CTD PMID:19028472 PMID:21342247 PMID:22225513 PMID:23963992 PMID:27871981 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat4 signal transducer and activator of transcription 4 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 9:49,472,660...49,588,540 JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]] CTD PMID:27871981 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Syp synaptophysin multiple interactions EXP Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]; Melatonin inhibits the reaction [Methamphetamine results in decreased expression of SYP protein] CTD PMID:17572393 PMID:19409439 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Syt5 synaptotagmin 5 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP [Tolmetin results in decreased activity of TDO2 protein] which results in increased abundance of Melatonin CTD PMID:16952380 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tf transferrin increases expression
multiple interactions
EXP Melatonin results in increased expression of TF protein
[Melatonin results in increased expression of TF protein] which affects the abundance of Iron
CTD PMID:18571630 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO
EXP
Melatonin inhibits the reaction [nickel chloride results in decreased expression of TFAM protein]
Melatonin inhibits the reaction [Carbon Tetrachloride results in decreased expression of TFAM protein]
CTD PMID:21797922 PMID:26882442 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tff1 trefoil factor 1 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A promotes the reaction [ESR1 protein binds to TFF1 promoter]]; Melatonin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to TFF1 promoter]] CTD PMID:27551335 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tfrc transferrin receptor decreases expression EXP Melatonin results in decreased expression of TFRC mRNA; Melatonin results in decreased expression of TFRC protein CTD PMID:17091493 PMID:18571630 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
[Tretinoin co-treated with Melatonin] results in increased expression of TGFB1 mRNA
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]
Melatonin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]
CTD PMID:9649124 PMID:17572393 PMID:23963992 PMID:26882442 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP
ISO
Melatonin inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; Melatonin inhibits the reaction [Rotenone results in decreased expression of TH protein]
Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; Melatonin inhibits the reaction [manganese chloride results in decreased expression of TH protein]
CTD PMID:18289173 PMID:19409439 PMID:20964710 PMID:24969583 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Melatonin inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] CTD PMID:16934674 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TLR4 protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased localization of TLR4 protein]; Melatonin inhibits the reaction [TLR4 protein promotes the reaction [MYD88 protein binds to LY96 protein binds to CD14 protein]] CTD PMID:27413111 PMID:28238930 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO
EXP
Gonadal Steroid Hormones affects the reaction [Melatonin affects the expression of TNF protein]; Melatonin inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
melatonin inhibits the reaction [liver reperfusion increases secretion of Tnf protein in plasma]
Melatonin results in decreased secretion of TNF protein
luzindole inhibits the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; MTNR1B protein promotes the reaction [Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]]
[Melatonin co-treated with Folic Acid] inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; Melatonin inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Melatonin inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of and results in increased secretion of TNF protein]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNF protein]
CTD
RGD
PMID:15714805 PMID:16373423 PMID:17602819 PMID:19028472 PMID:19080501 More... RGD:2325259 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases response to substance ISO TNFRSF1B protein results in increased susceptibility to Melatonin CTD PMID:21342247 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO
EXP
Melatonin results in increased expression of TP53 protein
Melatonin inhibits the reaction [Cisplatin results in increased phosphorylation of and results in increased expression of TP53 protein]
Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]
Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]; Melatonin inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TP53 protein]
CTD PMID:12071473 PMID:14993511 PMID:19012662 PMID:20041988 PMID:20964710 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO Melatonin inhibits the reaction [sodium arsenite results in increased expression of TRADD protein] CTD PMID:29763682 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Trappc6a trafficking protein particle complex subunit 6A multiple interactions ISO Melatonin inhibits the reaction [cyfluthrin results in decreased expression of TRAPPC6A mRNA] CTD PMID:31330490 NCBI chr 1:79,158,587...79,165,502
Ensembl chr 1:79,158,529...79,165,493
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Melatonin inhibits the reaction [Cadmium Chloride affects the expression of TSHB]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of TSHB mRNA]; Melatonin inhibits the reaction [Cadmium results in decreased expression of TSHB mRNA] CTD PMID:16948784 PMID:23085516 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]] CTD PMID:27871981 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO TWIST1 protein affects the reaction [Melatonin results in decreased expression of PROM1 protein] CTD PMID:30421542 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Ubb ubiquitin B multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr10:47,247,629...47,249,335
Ensembl chr10:47,245,637...47,249,333
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP Melatonin inhibits the reaction [ferric 8-hydroxyquinoline results in increased expression of UGT1A6 mRNA]; Melatonin inhibits the reaction [Paraquat results in increased expression of UGT1A6 mRNA] CTD PMID:22846377 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Vamp5 vesicle-associated membrane protein 5 multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 4:104,423,813...104,435,059
Ensembl chr 4:104,423,820...104,426,212
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Melatonin inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:32554039 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vps45 vacuolar protein sorting 45 homolog multiple interactions ISO Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions EXP Melatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein] CTD PMID:17645694 PMID:28070110 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions ISO Melatonin promotes the reaction [YWHAB protein binds to BAD protein] CTD PMID:18078454 NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
JBrowse link
G Yy1 YY1 transcription factor decreases expression
multiple interactions
ISO Melatonin results in decreased expression of YY1 mRNA
Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 mRNA]; Melatonin inhibits the reaction [Ethanol results in increased expression of YY1 protein]; MIR497 mRNA affects the reaction [Melatonin results in decreased expression of YY1 mRNA]
CTD PMID:28095641 NCBI chr 6:127,706,739...127,731,907
Ensembl chr 6:127,707,596...127,732,747
JBrowse link
G Zp2 zona pellucida glycoprotein 2 multiple interactions ISO Melatonin inhibits the reaction [bisphenol A results in increased cleavage of ZP2 protein]; Melatonin inhibits the reaction [Ethinyl Estradiol results in increased cleavage of ZP2 protein] CTD PMID:28178360 PMID:31931096 NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288
JBrowse link
muramyl dipeptide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 multiple interactions ISO [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of ATF3 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [15-acetyldeoxynivalenol results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which results in increased stability of ATF3 mRNA; ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein] CTD PMID:22003189 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G B2m beta-2 microglobulin increases activity ISO Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of B2M protein CTD PMID:15905553 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Cd40 CD40 molecule multiple interactions
increases expression
ISO [2,3-bis(palmitoyloxy)-2-propyl-N-palmitoyl-cysteinyl-seryl-seryl-asparaginyl-alanine co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased expression of CD40 protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine] results in increased expression of CD40 protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD40 protein
Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD40 protein
CTD PMID:16299289 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine] results in increased expression of CD80 protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD80 protein
Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD80 protein
CTD PMID:16299289 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd83 CD83 molecule multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine] results in increased expression of CD83 protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD83 protein
Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD83 protein
CTD PMID:16299289 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine] results in increased expression of CD86 protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of CD86 protein
Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of CD86 protein
CTD PMID:16299289 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA] CTD PMID:22003189 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA] CTD PMID:22003189 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Egf epidermal growth factor increases expression ISO muramyl dipeptide increases expression of Egf mRNA in splenocytes RGD PMID:30615126 RGD:39938959 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions ISO [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the localization of ELAVL1 protein; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL8 mRNA] CTD PMID:22003189 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO muramyl dipeptide increases expression of Ido1 mRNA in peritoneal macrophages and splenocytes RGD PMID:30615126 RGD:39938959 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL23A protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of IL12B protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12B mRNA; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of IL12B protein]
Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
CTD PMID:16299289 PMID:18490488 PMID:19897531 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12A mRNA; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]] CTD PMID:16299289 PMID:18490488 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B increases secretion
multiple interactions
ISO Acetylmuramyl-Alanyl-Isoglutamine analog results in increased secretion of IL12B protein
Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12B mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL23A protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of IL12B protein; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with resiquimod co-treated with IFNG protein] results in increased expression of IL12B mRNA; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12A protein binds to IL12B protein]]; resiquimod promotes the reaction [[Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of IL12B protein]
CTD PMID:15905553 PMID:16299289 PMID:18490488 PMID:19897531 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il15 interleukin 15 multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA CTD PMID:16299289 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [Pamidronate results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine] which results in increased secretion of IL18 protein CTD PMID:21282739 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha increases response to substance ISO IL1A protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine CTD PMID:19897531 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta affects expression
multiple interactions
increases secretion
increases response to substance
ISO Acetylmuramyl-Alanyl-Isoglutamine affects the expression of IL1B protein
[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein; geraniol inhibits the reaction [[Pamidronate co-treated with Acetylmuramyl-Alanyl-Isoglutamine] results in increased secretion of IL1B protein]
Acetylmuramyl-Alanyl-Isoglutamine results in increased secretion of IL1B protein
[Acetylmuramyl-Alanyl-Isoglutamine co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form
IL1B protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine
CTD PMID:17404311 PMID:19897531 PMID:21282739 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL23A protein] CTD PMID:18490488 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il6 interleukin 6 increases secretion ISO Acetylmuramyl-Alanyl-Isoglutamine analog results in increased secretion of IL6 protein CTD PMID:15905553 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases response to substance ISO MYD88 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog CTD PMID:15905553 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases phosphorylation
ISO Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of NFKBIA protein] CTD PMID:18413660 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions
increases expression
ISO [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] which co-treated with deoxynivalenol] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein] promotes the reaction [[ELAVL1 protein binds to ATF3 3' UTR] which results in increased stability of ATF3 mRNA]; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the localization of ELAVL1 protein; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of ATF3 mRNA; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA; [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL8 mRNA; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [15-acetyldeoxynivalenol results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL8 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which affects the localization of ELAVL1 protein; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which results in increased stability of ATF3 mRNA; Acetylmuramyl-Alanyl-Isoglutamine binds to and affects the activity of NOD2 protein; Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]; ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL1 mRNA]; ELAVL1 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] results in increased stability of CXCL8 mRNA]
Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of NOD2 protein
CTD PMID:18413660 PMID:22003189 PMID:28450277 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases activity
ISO [[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein; Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein; ATF3 protein affects the reaction [[[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] which co-treated with deoxynivalenol] affects the phosphorylation of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of and affects the localization of RELA protein]; helenalin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased activity of RELA protein]; parthenolide inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased phosphorylation of RELA protein] CTD PMID:18413660 PMID:22003189 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO Acetylmuramyl-Alanyl-Isoglutamine results in decreased expression of SOCS1 protein CTD PMID:19897531 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Tlr2 toll-like receptor 2 increases activity
increases response to substance
ISO Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein
TLR2 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog
CTD PMID:15905553 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 increases activity
increases response to substance
ISO Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR4 protein
TLR4 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog
CTD PMID:15905553 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases response to substance
multiple interactions
ISO Acetylmuramyl-Alanyl-Isoglutamine analog results in increased secretion of TNF protein
TNF protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine
Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Plant Extracts inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine results in increased expression of TNF protein]
CTD PMID:15905553 PMID:17568627 PMID:19897531 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
plerixafor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]
CTD PMID:18660423 PMID:29510123 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein] CTD PMID:28844962 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases expression
ISO plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
plerixafor results in decreased expression of CXCL12 mRNA
CTD PMID:12220670 PMID:18660423 PMID:24157575 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases activity
multiple interactions
decreases expression
ISO plerixafor results in decreased activity of CXCR4 protein
plerixafor binds to and results in decreased activity of CXCR4 protein; plerixafor inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of CXCR4 protein]
plerixafor results in decreased expression of CXCR4 protein
CTD PMID:12220670 PMID:17121897 PMID:28844962 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein] CTD PMID:18660423 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions ISO plerixafor inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of SNAI2 protein] CTD PMID:28844962 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Particulate Matter results in decreased susceptibility to [VEGFA protein modified form co-treated with plerixafor]
plerixafor inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
CTD PMID:22418586 PMID:25815440 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
plumbagin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO
EXP
plumbagin results in increased phosphorylation of AKT1 protein
plumbagin inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
CTD PMID:20028456 PMID:32691977 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:32691977 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO [Plumbagin alone or cotreated with IL-6] decreases expression of BCL2L1 mRNA in liver RGD PMID:25815436 RGD:126925996 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
plumbagin results in increased activity of CASP3 protein
NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]; plumbagin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]
CTD PMID:20028456 PMID:20576514 PMID:32691977 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO plumbagin results in increased activity of CASP8 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP8 protein]
CTD PMID:20576514 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [plumbagin results in increased activity of CASP9 protein] CTD PMID:20576514 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:32691977 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of CCL2 protein] CTD PMID:32691977 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO [Plumbagin alone or cotreated with IL-6] decreases expression of CCND1 mRNA in liver RGD PMID:25815436 RGD:126925996 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ctrl chymotrypsin-like multiple interactions
decreases activity
ISO Acetylcysteine inhibits the reaction [plumbagin results in decreased activity of CTRL protein] CTD PMID:31276663 NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO plumbagin results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of DDIT3 protein]
CTD PMID:31276663 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) decreases activity ISO
EXP
plumbagin results in decreased activity of DHODH protein CTD PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Fabp3 fatty acid binding protein 3 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of FABP3 protein] CTD PMID:32691977 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO plumbagin results in increased expression of FAS mRNA; plumbagin results in increased expression of FAS protein CTD PMID:20576514 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:22960630 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO plumbagin results in increased expression of GCLM mRNA CTD PMID:20028456 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression ISO plumbagin results in increased expression of GSTP1 mRNA CTD PMID:20028456 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hk1 hexokinase 1 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in decreased activity of HK1 protein] CTD PMID:22960630 NCBI chr20:30,230,488...30,332,161
Ensembl chr20:30,230,486...30,332,131
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein]
plumbagin promotes the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]
plumbagin results in increased expression of HMOX1 mRNA; plumbagin results in increased expression of HMOX1 protein
CTD PMID:20028456 PMID:32691977 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO plumbagin results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [plumbagin results in increased expression of HSPA5 protein]
CTD PMID:31276663 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
plumbagin inhibits the reaction [IFNG protein results in increased abundance of Nitrites]
plumbagin inhibits the reaction [Doxorubicin results in increased expression of IFNG protein]
CTD PMID:23942037 PMID:32691977 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO plumbagin results in increased phosphorylation of MAPK1 protein CTD PMID:20028456 PMID:20576514 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO plumbagin results in increased phosphorylation of MAPK3 protein CTD PMID:20028456 PMID:20576514 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO [Plumbagin alone and cotreated with IL-6] decreases expression of MMP9 in liver RGD PMID:25815436 RGD:126925996 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
affects response to substance
ISO
EXP
NFE2L2 mRNA affects the reaction [plumbagin results in decreased susceptibility to tert-Butylhydroperoxide]; NFE2L2 mRNA affects the reaction [plumbagin results in increased expression of HMOX1 mRNA]
plumbagin affects the localization of NFE2L2 protein
NFE2L2 protein mutant form affects the reaction [plumbagin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]
NFE2L2 mRNA affects the susceptibility to plumbagin
CTD PMID:20028456 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein] CTD PMID:32691977 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO plumbagin results in increased expression of NQO1 mRNA; plumbagin results in increased expression of NQO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [plumbagin results in increased expression of NQO1 protein]; wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]
CTD PMID:20028456 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Per2 period circadian regulator 2 decreases response to substance ISO PER2 protein mutant form results in decreased susceptibility to plumbagin CTD PMID:25628599 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in decreased phosphorylation of PTEN protein] CTD PMID:32691977 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 multiple interactions ISO plumbagin binds to and results in decreased activity of PTPN2 protein CTD PMID:31248982 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Pygb glycogen phosphorylase B multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of PYGB protein] CTD PMID:32691977 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; plumbagin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:22960630 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO plumbagin results in increased expression of SQSTM1 protein CTD PMID:31276663 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein] CTD PMID:32691977 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP plumbagin inhibits the reaction [Doxorubicin results in increased expression of TNNI3 protein] CTD PMID:32691977 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO plumbagin results in increased expression of TXNRD1 mRNA CTD PMID:20028456 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of plumbagin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Plumbagin decreases expression of VEGFA mRNA in liver RGD PMID:25815436 RGD:126925996 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
poly(I:C) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ABHD2 mRNA CTD PMID:26923065 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
JBrowse link
G Ablim1 actin-binding LIM protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ABLIM1 mRNA CTD PMID:26923065 NCBI chr 1:256,084,293...256,372,075 JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ACADS mRNA CTD PMID:26923065 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ADAM10 mRNA CTD PMID:26923065 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889
JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of AHCYL1 mRNA CTD PMID:26923065 NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression ISO Poly I-C results in increased expression of AHR mRNA; Poly I-C results in increased expression of AHR protein CTD PMID:27783115 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap5 A-kinase anchoring protein 5 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of AKAP5 mRNA CTD PMID:26923065 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of APP mRNA CTD PMID:26923065 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 increases degradation
multiple interactions
ISO Poly I-C results in increased degradation of APPL1 protein
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]
CTD PMID:25780039 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects methylation EXP Poly I-C affects the methylation of ARC promoter CTD PMID:32843831 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Arfgef3 ARFGEF family member 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARFGEF3 mRNA CTD PMID:26923065 NCBI chr 1:13,245,578...13,404,319
Ensembl chr 1:13,244,830...13,404,084
JBrowse link
G Arg2 arginase 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARG2 mRNA CTD PMID:26923065 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP11A mRNA CTD PMID:26923065 NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
JBrowse link
G Arhgap44 Rho GTPase activating protein 44 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGAP44 mRNA CTD PMID:26923065 NCBI chr10:49,655,583...49,822,876
Ensembl chr10:49,655,584...49,824,297
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP9 mRNA CTD PMID:26923065 NCBI chr 7:63,148,573...63,157,025
Ensembl chr 7:63,148,900...63,157,524
JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF12 mRNA CTD PMID:26923065 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF7 mRNA CTD PMID:26923065 NCBI chr16:77,671,021...77,782,593
Ensembl chr16:77,671,023...77,782,697
JBrowse link
G Arsb arylsulfatase B multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ARSB mRNA CTD PMID:26923065 NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of ART3 mRNA CTD PMID:26923065 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Poly I-C results in increased expression of ATF3 mRNA CTD PMID:27783115 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ATP2B2 mRNA CTD PMID:26923065 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Atxn3 ataxin 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of ATXN3 mRNA CTD PMID:26923065 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Poly I-C results in increased expression of BAX protein CTD PMID:21418039 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Poly I-C results in decreased expression of BCL2 protein CTD PMID:21418039 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BCL2A1 mRNA CTD PMID:26923065 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
affects methylation
ISO
EXP
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of BDNF mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of BDNF mRNA]
Poly I-C affects the methylation of BDNF promoter
CTD PMID:24889602 PMID:32843831 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO Poly I-C results in decreased expression of BID protein CTD PMID:21418039 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Poly I-C promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein] CTD PMID:21418039 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BIRC6 mRNA CTD PMID:26923065 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434
JBrowse link
G Blmh bleomycin hydrolase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of BLMH mRNA CTD PMID:26923065 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
JBrowse link
G Brms1l BRMS1 like transcriptional repressor multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BRMS1L mRNA CTD PMID:26923065 NCBI chr 6:73,266,673...73,300,631
Ensembl chr 6:73,266,691...73,300,631
JBrowse link
G Brox BRO1 domain and CAAX motif containing multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of BROX mRNA CTD PMID:26923065 NCBI chr13:94,920,107...94,940,189
Ensembl chr13:94,920,112...94,940,227
JBrowse link
G C1qtnf7 C1q and TNF related 7 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of C1QTNF7 mRNA CTD PMID:26923065 NCBI chr14:67,467,888...67,580,477
Ensembl chr14:67,468,014...67,580,410
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CA3 mRNA CTD PMID:26923065 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Cage1 cancer antigen 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CAGE1 mRNA CTD PMID:26923065 NCBI chr17:26,789,975...26,828,210
Ensembl chr17:26,790,033...26,828,204
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:21418039 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
ISO arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein] CTD PMID:21418039 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein] CTD PMID:21418039 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression EXP Poly I-C results in decreased expression of CAT mRNA CTD PMID:23939143 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CAV1 mRNA CTD PMID:26923065 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cbx1 chromobox 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CBX1 mRNA CTD PMID:26923065 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
JBrowse link
G Cbx6 chromobox 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CBX6 mRNA CTD PMID:26923065 NCBI chr 7:111,372,979...111,383,109
Ensembl chr 7:111,372,980...111,383,091
JBrowse link
G Ccdc113 coiled-coil domain containing 113 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CCDC113 mRNA CTD PMID:26923065 NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Poly I-C results in increased expression of CCL1 mRNA CTD PMID:27783115 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions
increases secretion
ISO methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL11 protein] CTD PMID:24056979 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
ISO
EXP
methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL2 protein]
Poly I-C results in increased expression of CCL2 mRNA
CTD PMID:23939143 PMID:24056979 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL3 protein] CTD PMID:19500611 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions
increases expression
increases secretion
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]
6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]
CTD PMID:19500611 PMID:24056979 PMID:27783115 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression
increases secretion
ISO APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL5 protein]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]
Poly I-C results in increased expression of CCL5; Poly I-C results in increased expression of CCL5 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of CCL5]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of CCL5]
CTD PMID:23688403 PMID:24056979 PMID:24709138 PMID:25780039 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd40 CD40 molecule increases expression
multiple interactions
ISO Poly I-C results in increased expression of CD40 protein
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein
CTD PMID:15246609 PMID:16224278 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd80 Cd80 molecule increases expression ISO Poly I-C results in increased expression of CD80 protein CTD PMID:15246609 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd83 CD83 molecule increases expression
multiple interactions
ISO Poly I-C results in increased expression of CD83 protein
CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]
CTD PMID:17698565 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule multiple interactions
increases expression
ISO [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein] CTD PMID:15246609 PMID:16224278 PMID:16890772 PMID:17698565 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdx2 caudal type homeo box 2 multiple interactions ISO [Poly I-C co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA; [Poly I-C co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA CTD PMID:27783115 NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
JBrowse link
G Celf1 CUGBP, Elav-like family member 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CELF1 mRNA CTD PMID:26923065 NCBI chr 3:76,924,591...76,999,429
Ensembl chr 3:76,924,613...76,999,426
JBrowse link
G Cfp complement factor properdin multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CFP mRNA CTD PMID:26923065 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Chsy1 chondroitin sulfate synthase 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CHSY1 mRNA CTD PMID:26923065 NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601
JBrowse link
G Cibar2 CBY1 interacting BAR domain containing 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CIBAR2 mRNA CTD PMID:26923065 NCBI chr19:48,217,617...48,229,418
Ensembl chr19:48,215,486...48,229,404
JBrowse link
G Clcc1 chloride channel CLIC-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CLCC1 mRNA CTD PMID:26923065 NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913
JBrowse link
G Clec14a C-type lectin domain containing 14A multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CLEC14A mRNA CTD PMID:26923065 NCBI chr 6:75,881,470...75,884,612
Ensembl chr 6:75,881,473...75,884,612
JBrowse link
G Clip3 CAP-GLY domain containing linker protein 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CLIP3 mRNA CTD PMID:26923065 NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184
JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CNNM1 mRNA CTD PMID:26923065 NCBI chr 1:242,296,367...242,354,908
Ensembl chr 1:242,296,422...242,353,513
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Cannabidiol inhibits the reaction [Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]]; Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein] CTD PMID:31202911 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP Poly I-C results in increased expression of CNR2 mRNA CTD PMID:27317300 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548
JBrowse link
G Cntn1 contactin 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CNTN1 mRNA CTD PMID:26923065 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541
JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CRABP1 mRNA CTD PMID:26923065 NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CSF2 protein] CTD PMID:19500611 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cttnbp2 cortactin binding protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CTTNBP2 mRNA CTD PMID:26923065 NCBI chr 4:46,800,975...46,964,681
Ensembl chr 4:46,800,981...46,964,631
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Poly I-C results in increased expression of CXCL1 mRNA CTD PMID:23939143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions
increases expression
ISO
EXP
APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
Poly I-C results in increased expression of CXCL10 mRNA; Poly I-C results in increased expression of CXCL10 protein
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Phosphorothioate Oligonucleotides inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]
CTD PMID:19426678 PMID:25780039 PMID:26682054 PMID:28003376 PMID:28572013 More... NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression EXP Poly I-C results in increased expression of CXCL2 mRNA CTD PMID:23939143 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions
increases expression
ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CXCL1 protein] CTD PMID:19500611 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions
increases secretion
increases expression
ISO Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CXCL9 protein] CTD PMID:19426678 PMID:24056979 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyfip2 cytoplasmic FMR1 interacting protein 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CYFIP2 mRNA CTD PMID:26923065 NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Poly I-C promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA] CTD PMID:27783115 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Poly I-C results in decreased expression of CYP2C11 mRNA CTD PMID:23939143 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression EXP Poly I-C results in decreased expression of CYP2C6V1 mRNA CTD PMID:23939143 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Poly I-C results in decreased expression of CYP2C7 mRNA CTD PMID:23939143 NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Poly I-C results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:23939143 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyria CYFIP related Rac1 interactor A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of CYRIA mRNA CTD PMID:26923065 NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668
JBrowse link
G Cysrt1 cysteine rich tail 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of CYSRT1 mRNA CTD PMID:26923065 NCBI chr 3:8,054,195...8,057,846
Ensembl chr 3:8,053,482...8,059,721
JBrowse link
G Dab1 DAB adaptor protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DAB1 mRNA CTD PMID:26923065 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Dck deoxycytidine kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCK mRNA CTD PMID:26923065 NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
JBrowse link
G Dcun1d3 defective in cullin neddylation 1 domain containing 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D3 mRNA CTD PMID:26923065 NCBI chr 1:174,243,001...174,285,647
Ensembl chr 1:66,494,848...66,496,343
Ensembl chr 1:66,494,848...66,496,343
JBrowse link
G Dcun1d4 defective in cullin neddylation 1 domain containing 4 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D4 mRNA CTD PMID:26923065 NCBI chr14:34,652,723...34,733,122
Ensembl chr14:34,652,723...34,733,207
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DDX3X mRNA CTD PMID:26923065 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Ddx58 DEXD/H-box helicase 58 increases expression
multiple interactions
ISO Poly I-C results in increased expression of DDX58 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of DDX58 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of DDX58 mRNA]
CTD PMID:27183587 PMID:30341573 PMID:31154625 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Defb4 defensin beta 4 increases secretion ISO Poly I-C results in increased secretion of DEFB4 protein CTD PMID:17669408 NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of DLG1 mRNA CTD PMID:26923065 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Dnm2 dynamin 2 multiple interactions ISO DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Eea1 early endosome antigen 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of EEA1 mRNA CTD PMID:26923065 NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
JBrowse link
G Egr1 early growth response 1 multiple interactions
affects methylation
ISO
EXP
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]
Poly I-C affects the methylation of EGR1 promoter
CTD PMID:24889602 PMID:32843831 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases expression
increases response to substance
ISO Poly I-C results in increased expression of EIF2AK2 mRNA
EIF2AK2 results in increased susceptibility to Poly I-C
CTD PMID:10944112 PMID:17669408 PMID:22558189 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Epc2l1 enhancer of polycomb homolog 2 (Drosophila)-like 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of EPC2L1 mRNA CTD PMID:26923065 NCBI chr 1:81,931,963...81,934,681
Ensembl chr 1:81,932,016...81,934,442
JBrowse link
G F11r F11 receptor multiple interactions
decreases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; RTKI cpd inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; SB 203580 inhibits the reaction [Poly I-C results in decreased expression of F11R protein] CTD PMID:20932985 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Poly I-C results in increased expression of FABP4 mRNA CTD PMID:15705927 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fam107a family with sequence similarity 107, member A multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of FAM107A mRNA CTD PMID:26923065 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Fmr1 FMRP translational regulator 1 multiple interactions
decreases expression
ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Fxyd3 FXYD domain-containing ion transport regulator 3 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of FXYD3 mRNA CTD PMID:26923065 NCBI chr 1:86,305,531...86,312,455 JBrowse link
G Fyttd1 forty-two-three domain containing 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of FYTTD1 mRNA CTD PMID:26923065 NCBI chr11:67,877,967...67,907,565
Ensembl chr11:67,877,967...67,907,511
JBrowse link
G G3bp2 G3BP stress granule assembly factor 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of G3BP2 mRNA CTD PMID:26923065 NCBI chr14:15,932,356...16,020,555
Ensembl chr14:15,987,417...16,020,548
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRA1 mRNA CTD PMID:26923065 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRB2 mRNA CTD PMID:26923065 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GABRG2 mRNA CTD PMID:26923065 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression
multiple interactions
EXP Poly I-C results in decreased expression of GAD1 protein
Cannabidiol inhibits the reaction [Poly I-C results in decreased expression of GAD1 protein]
CTD PMID:31202911 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GDAP1 mRNA CTD PMID:26923065 NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
JBrowse link
G Gdi1 GDP dissociation inhibitor 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GDI1 mRNA CTD PMID:26923065 NCBI chr  X:152,087,611...152,094,274
Ensembl chr  X:152,087,444...152,094,272
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of GET3 mRNA CTD PMID:26923065 NCBI chr19:23,130,109...23,138,196
Ensembl chr19:23,130,109...23,138,193
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Poly I-C results in increased expression of GFAP mRNA CTD PMID:27317300 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gh1 growth hormone 1 decreases expression ISO Poly I-C results in decreased expression of GH protein CTD PMID:21195166 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Glce glucuronic acid epimerase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLCE mRNA CTD PMID:26923065 NCBI chr 8:62,546,104...62,612,144
Ensembl chr 8:62,546,107...62,612,040
JBrowse link
G Glrb glycine receptor, beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLRB mRNA CTD PMID:26923065 NCBI chr 2:166,134,624...166,207,509
Ensembl chr 2:166,134,626...166,207,489
JBrowse link
G Glyr1 glyoxylate reductase 1 homolog multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GLYR1 mRNA CTD PMID:26923065 NCBI chr10:10,532,036...10,567,639
Ensembl chr10:10,532,154...10,567,637
JBrowse link
G Gmfb glia maturation factor, beta multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GMFB mRNA CTD PMID:26923065 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of GMPPB mRNA CTD PMID:26923065 NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286
JBrowse link
G Gpatch2l G patch domain containing 2-like multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GPATCH2L mRNA CTD PMID:26923065 NCBI chr 6:105,883,383...105,935,644
Ensembl chr 6:105,883,460...105,934,888
JBrowse link
G Gpbp1 GC-rich promoter binding protein 1 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of GPBP1 mRNA CTD PMID:26923065 NCBI chr 2:43,023,504...43,091,146
Ensembl chr 2:43,023,504...43,090,907
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP Poly I-C results in decreased expression of GSR mRNA CTD PMID:23939143 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gzmb granzyme B multiple interactions
increases expression
ISO Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB protein]
Poly I-C results in increased expression of GZMB mRNA; Poly I-C results in increased expression of GZMB protein
CTD PMID:23618096 NCBI chr15:30,343,361...30,346,792 JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of HEY2 mRNA CTD PMID:26923065 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA] CTD PMID:23939143 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Poly I-C results in increased expression of HSP90AA1 mRNA CTD PMID:23939143 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Poly I-C results in increased expression of HSPA1A mRNA CTD PMID:23939143
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Poly I-C results in increased expression of HSPA8 mRNA CTD PMID:23939143 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases expression ISO Poly I-C results in increased expression of HTR2A mRNA CTD PMID:24889602 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Ibtk inhibitor of Bruton tyrosine kinase multiple interactions EXP [Poly I-C co-treated with HU 211] results in decreased expression of IBTK mRNA CTD PMID:26923065 NCBI chr 8:86,625,591...86,698,661
Ensembl chr 8:86,625,597...86,698,260
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IDO1 mRNA
poly(I:C) co-treated with tryptophan or alone increases activity and expression of IDO1 protein in Langerhans cell-like dendritic cells
CTD
RGD
PMID:27783115 PMID:26198597 RGD:11528429 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases expression ISO Poly I-C results in increased expression of IDO2 mRNA CTD PMID:27783115 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IFIH1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]
CTD PMID:30341573 PMID:31154625 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA]]; Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA] CTD PMID:34051100 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Ifna1 interferon, alpha 1 increases expression EXP Poly I-C results in increased expression of IFNA1 mRNA CTD PMID:28726298 NCBI chr 5:103,095,767...103,098,260 JBrowse link
G Ifnb1 interferon beta 1 increases expression
increases secretion
multiple interactions
ISO
EXP
Poly I-C results in increased expression of IFNB1 mRNA; Poly I-C results in increased expression of IFNB1 protein
Poly I-C results in increased secretion of IFNB1 protein
MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; BX795 inhibits the reaction [Poly I-C results in increased expression of IFNB1 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Progesterone inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Resveratrol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]
CTD PMID:16116226 PMID:16399790 PMID:17669408 PMID:18279804 PMID:18323514 More... NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions
increases secretion
increases expression
ISO
EXP
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein; [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNG mRNA]
Poly I-C results in increased secretion of IFNG protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IFNG protein]
Poly I-C results in increased expression of IFNG mRNA; Poly I-C results in increased expression of IFNG protein
CTD PMID:9328138 PMID:16224278 PMID:17321468 PMID:19500611 PMID:23618096 More... NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]
Poly I-C results in decreased expression of IGF1 mRNA; Poly I-C results in decreased expression of IGF1 protein
CTD PMID:1705203 PMID:21195166 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 multiple interactions
decreases expression
ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein] CTD PMID:21195166 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 multiple interactions EXP [Poly I-C co-treated with HU 211] results in increased expression of IGSF6 mRNA CTD PMID:26923065 NCBI chr 1:175,610,167...175,620,662
Ensembl chr 1:175,610,167...175,620,722
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions
increases phosphorylation
ISO APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein] CTD PMID:25780039 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
increases secretion
ISO
EXP
CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]
Poly I-C results in increased expression of IL10 mRNA
Poly I-C results in increased expression of IL10 mRNA; Poly I-C results in increased expression of IL10 protein
Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]
CTD PMID:16224278 PMID:17698565 PMID:22771370 PMID:23618096 PMID:23939143 More... NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression
ISO 6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; indole-3-carbinol inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA] CTD PMID:27783115 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression
ISO [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]
Poly I-C results in increased expression of IL12B mRNA; Poly I-C results in increased expression of IL12B protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA]
CTD PMID:16890772 PMID:19426678 PMID:19500611 PMID:23266719 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il17a interleukin 17A increases expression ISO Poly I-C results in increased expression of IL17A protein CTD PMID:30836164 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
increases expression
ISO
EXP
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]
Poly I-C results in increased secretion of IL1B protein
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 6-formylindolo(3,2-b)carbazole promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; Tetrachlorodibenzodioxin promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]
Poly I-C results in increased expression of IL1B mRNA; Poly I-C results in increased expression of IL1B protein
CTD PMID:16687389 PMID:17321468 PMID:19500611 PMID:22771370 PMID:23618096 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 increases expression
increases secretion
ISO Poly I-C results in increased expression of IL2 mRNA
Poly I-C results in increased secretion of IL2 protein
CTD PMID:9328138 PMID:23618096 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il27 interleukin 27 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IL27 mRNA
Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]
CTD PMID:19426678 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions
ISO Poly I-C results in increased expression of IL33 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Poly I-C results in increased expression of IL33 protein]
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL33 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL33 protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL33 protein]
CTD PMID:25747661 PMID:30017638 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
increases secretion
increases response to substance
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; [Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone; [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expres