The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
Doxycycline results in decreased expression of ABCB1 protein Doxycycline results in increased expression of ABCB1 protein MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]
Doxycycline results in increased expression of ABCC1 protein MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein]
[[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA [Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA; Doxycycline results in increased expression of AHR protein
Doxycycline inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]
[[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA [Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]]
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the phosphorylation of CREB1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]]
Doxycycline results in increased expression of HMOX1 protein Doxycycline promotes the reaction [erastin results in increased expression of HMOX1 mRNA]; ferrostatin-1 inhibits the reaction [HMOX1 protein results in increased susceptibility to Doxycycline]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein]
Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
MB protein results in increased susceptibility to Doxycycline Doxycycline results in increased expression of MB protein Doxycycline promotes the reaction [erastin results in increased expression of MB mRNA]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCB1 protein]; MB protein inhibits the reaction [Doxycycline results in increased expression of ABCC1 protein]; MB protein promotes the reaction [Doxycycline results in decreased expression of GPX4 protein]; MB protein promotes the reaction [Doxycycline results in increased expression of HMOX1 protein]
Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] Doxycycline analog results in decreased activity of MMP13 protein Doxycycline results in increased expression of MMP13 mRNA
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2] Doxycycline analog results in decreased activity of MMP2 protein Doxycycline results in decreased expression of MMP2 protein Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein] Doxycycline results in decreased activity of MMP2 protein
Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] Doxycycline results in decreased activity of MMP3 protein Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein] Doxycycline results in decreased expression of MMP9 protein Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein] Doxycycline results in decreased activity of MMP9 protein
Doxycycline results in decreased stability of and results in decreased expression of NOS2 mRNA Doxycycline results in decreased expression of NOS2 protein
[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]; [Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 mRNA]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the expression of NR4A1 protein]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the methylation of NR4A1 promoter]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREB1 protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [CREBBP protein binds to NR4A1 promoter]]; methylmercuric chloride affects the reaction [[Doxycycline co-treated with Bucladesine co-treated with GDNF protein] affects the reaction [EZH2 protein binds to NR4A1 promoter]]
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein]
[Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein]
Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
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