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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:doxycycline
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Accession:CHEBI:50845 term browser browse the term
Definition:Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
Synonyms:related_synonym: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE;   5-hydroxy-alpha-6-deoxytetracycline;   6alpha-deoxy-5-oxytetracycline;   Doxycyclin;   Formula=C22H24N2O8;   InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1;   InChIKey=JBIWCJUYHHGXTC-AKNGSSGZSA-N;   Jenacyclin;   SMILES=[H][C@@]12[C@@H](C)c3cccc(O)c3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]2O;   Supracyclin;   Vibramycin;   doxiciclina;   doxycycline (anhydrous);   doxycyclinum
 alt_id: CHEBI:42135;   CHEBI:4713
 xref: Beilstein:3041790;   CAS:564-25-0;   DrugBank:DB00254;   Drug_Central:961;   KEGG:C06973;   KEGG:D07876;   KNApSAcK:C00017127
 xref_mesh: MESH:D004318
 xref: PDBeChem:DXT;   PMID:1650428;   Patent:US3019260;   Patent:US3200149;   Reaxys:3041790;   VSDB:1840;   Wikipedia:Doxycycline


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doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Doxycycline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Doxycycline results in decreased expression of ABCB1 protein CTD PMID:11147995 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Doxycycline results in decreased expression of ABCB4 mRNA CTD PMID:27765674 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Doxycycline results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Doxycycline results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Doxycycline results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of ACTA2 mRNA] CTD PMID:18089841 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ada adenosine deaminase multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ADA mRNA] CTD PMID:18089841 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947
JBrowse link
G Agt angiotensinogen multiple interactions EXP Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein] CTD PMID:20837116 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression
ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA; Doxycycline results in increased expression of AHR protein
CTD PMID:22273977 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ang angiogenin multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of ANG mRNA] CTD PMID:18089841 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of ATF2 protein] CTD PMID:18089841 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAD protein] CTD PMID:17673183 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:17673183 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:17673183 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 protein] CTD PMID:17673183 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; Doxycycline inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein] CTD PMID:17673183 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccng2 cyclin G2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CCNG2 mRNA] CTD PMID:18089841 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of CDKN1A mRNA] CTD PMID:18089841 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO [[Doxycycline results in increased expression of AHR protein] which co-treated with Tobacco Smoke Pollution] results in increased expression of CYP1B1 mRNA
[Doxycycline results in increased expression of AHR protein] which results in increased expression of CYP1B1 mRNA
CTD PMID:22273977 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of DDIT4 mRNA] CTD PMID:18089841 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA] CTD PMID:18089841 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of GEM mRNA] CTD PMID:18089841 NCBI chr 5:25,339,479...25,353,661
Ensembl chr 5:25,349,928...25,353,661
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of GJA1 mRNA] CTD PMID:18089841 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Doxycycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA] CTD PMID:17267227 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25977597 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of LCN2 mRNA] CTD PMID:18089841 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Map3k6 mitogen-activated protein kinase kinase kinase 6 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K6 mRNA] CTD PMID:18089841 NCBI chr 5:151,435,679...151,448,329
Ensembl chr 5:151,436,464...151,448,328
JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MAP3K8 mRNA] CTD PMID:18089841 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK14 protein] CTD PMID:18089841 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression
decreases activity
ISO Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Doxycycline results in increased expression of MMP13 mRNA
Doxycycline analog results in decreased activity of MMP13 protein
CTD PMID:17267227, PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2]
Doxycycline results in decreased activity of MMP2 protein
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein]
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Doxycycline results in decreased expression of MMP2 protein
Doxycycline analog results in decreased activity of MMP2 protein
CTD PMID:17267227, PMID:17498959, PMID:18089841, PMID:18178469, PMID:18836702, PMID:19375915, PMID:20837116 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases activity
ISO Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]
Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]
Doxycycline results in decreased activity of MMP3 protein
CTD PMID:17267227, PMID:18089841 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Doxycycline analog results in decreased activity of MMP8 protein CTD PMID:17267227 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases activity
decreases expression
ISO
EXP
Doxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP9]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 mRNA]; Doxycycline inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of MMP9 protein]
Doxycycline results in decreased activity of MMP9 protein
Doxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP9 protein]
Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Doxycycline results in decreased expression of MMP9 protein
CTD PMID:15131573, PMID:17498959, PMID:18089841, PMID:18178469, PMID:19375915, PMID:20837116 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MT2 mRNA] CTD PMID:18089841 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:18089841 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO Doxycycline results in decreased stability of and results in decreased expression of NOS2 mRNA
Doxycycline results in decreased expression of NOS2 protein
CTD PMID:16365451 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of NOX4 mRNA] CTD PMID:18089841 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Osmr oncostatin M receptor multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of OSMR mRNA] CTD PMID:18089841 NCBI chr 2:56,107,491...56,163,522
Ensembl chr 2:56,110,777...56,151,531
JBrowse link
G Pla2g7 phospholipase A2 group VII multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of PLA2G7 mRNA] CTD PMID:18089841 NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A8 mRNA] CTD PMID:18089841 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S100A9 mRNA] CTD PMID:18089841 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 mRNA]; Doxycycline inhibits the reaction [Isoproterenol results in increased expression of S1PR1 protein] CTD PMID:18089841 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SERPINA3N mRNA] CTD PMID:18089841 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Doxycycline results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Doxycycline inhibits the reaction [SLC22A6 protein results in increased uptake of Anions] CTD PMID:11855680 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Smyd1 SET and MYND domain containing 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in decreased expression of SMYD1 mRNA] CTD PMID:18089841 NCBI chr 4:99,071,122...99,125,143
Ensembl chr 4:99,074,535...99,125,111
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of SOCS3 mRNA] CTD PMID:18089841 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Doxycycline inhibits the reaction [Doxorubicin results in decreased expression of SOD1 protein] CTD PMID:17673183 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions
decreases expression
ISO [Doxycycline analog results in decreased expression of TARDBP protein] inhibits the reaction [sodium arsenite affects the localization of TARDBP protein] CTD PMID:24019256 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TGFBR2 mRNA] CTD PMID:18089841 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Doxycycline inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Doxycycline inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:16134060, PMID:25977597 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 multiple interactions ISO Doxycycline inhibits the reaction [Isoproterenol results in increased expression of TRP53INP1 mRNA] CTD PMID:18089841 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases expression
multiple interactions
ISO Doxycycline results in increased expression of UGT1A8 mRNA
Doxycycline promotes the reaction [Tobacco Smoke Pollution results in increased expression of UGT1A8 mRNA]
CTD PMID:22273977 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            tetracyclines 492
              doxycycline 56
                doxycycline HCl + 0
                doxycycline monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            organic hydride 18248
                              organic fundamental parent 18248
                                hydrocarbon 17968
                                  cyclic hydrocarbon 17062
                                    arene 17058
                                      polycyclic arene 16879
                                        ortho-fused polycyclic arene 9641
                                          acene 7566
                                            tetracene 7563
                                              tetracyclines 492
                                                doxycycline 56
                                                  doxycycline HCl + 0
                                                  doxycycline monohydrate 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.