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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:loxapine
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Accession:CHEBI:50841 term browser browse the term
Definition:A dibenzooxazepine that has formula C18H18ClN3O.
Synonyms:exact_synonym: 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
 related_synonym: 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine;   Cloxazepine;   Formula=C18H18ClN3O;   InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3;   InChIKey=XJGVXQDUIWGIRW-UHFFFAOYSA-N;   SMILES=CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12;   loxapina;   loxapinum;   oxilapine
 alt_id: CHEBI:50839;   CHEBI:6548
 xref: Beilstein:626753;   CAS:1977-10-2;   DrugBank:DB00408;   Drug_Central:1613;   KEGG:C07104;   KEGG:D02340;   LINCS:LSM-2881
 xref_mesh: MESH:D008152
 xref: Patent:NL6406089;   Patent:US3412193;   Patent:US3546226;   Wikipedia:Loxapine

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loxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases metabolic processing ISO CYP3A4 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Drd1 dopamine receptor D1 affects binding EXP Loxapine analog binds to DRD1 protein; Loxapine binds to DRD1 protein CTD PMID:9723970 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Loxapine analog binds to DRD2 protein; Loxapine binds to DRD2 protein CTD PMID:9723970 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP Loxapine analog binds to HTR1A protein; Loxapine binds to HTR1A protein CTD PMID:9723970 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding EXP Loxapine analog binds to HTR2A protein; Loxapine binds to HTR2A protein CTD PMID:9723970 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding EXP Loxapine analog binds to HTR2C protein; Loxapine binds to HTR2C protein CTD PMID:9723970 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Loxapine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          neurotransmitter agent 16447
            dopaminergic agent 5090
              dopaminergic antagonist 1191
                loxapine 9
                  loxapine succinate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                organic heterocyclic compound 18519
                                  organic heteropolycyclic compound 17979
                                    organic heterotricyclic compound 14602
                                      dibenzooxazepine 22
                                        loxapine 9
                                          loxapine succinate 0
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