CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: loxapine
Accession: CHEBI:50841
browse the term
Definition: A dibenzooxazepine that has formula C18H18ClN3O.
Synonyms: exact_synonym: 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
related_synonym: 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine; Cloxazepine; Formula=C18H18ClN3O; InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3; InChIKey=XJGVXQDUIWGIRW-UHFFFAOYSA-N; SMILES=CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12; loxapina; loxapinum; oxilapine
alt_id: CHEBI:50839; CHEBI:6548
xref: Beilstein:626753; CAS:1977-10-2; DrugBank:DB00408; Drug_Central:1613; KEGG:C07104; KEGG:D02340; LINCS:LSM-2881
xref_mesh: MESH:D008152
xref: Patent:NL6406089; Patent:US3412193; Patent:US3546226; Wikipedia:Loxapine
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases metabolic processing
ISO
CYP1A2 results in increased metabolism of Loxapine
CTD
PMID:21826677
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases metabolic processing
ISO
CYP2D6 results in increased metabolism of Loxapine
CTD
PMID:21826677
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing
ISO
CYP3A4 results in increased metabolism of Loxapine
CTD
PMID:21826677
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Drd1
dopamine receptor D1
affects binding
EXP
Loxapine analog binds to DRD1 protein; Loxapine binds to DRD1 protein
CTD
PMID:9723970
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
affects binding
EXP
Loxapine analog binds to DRD2 protein; Loxapine binds to DRD2 protein
CTD
PMID:9723970
NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
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Htr1a
5-hydroxytryptamine receptor 1A
affects binding
EXP
Loxapine analog binds to HTR1A protein; Loxapine binds to HTR1A protein
CTD
PMID:9723970
NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
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Htr2a
5-hydroxytryptamine receptor 2A
affects binding
EXP
Loxapine analog binds to HTR2A protein; Loxapine binds to HTR2A protein
CTD
PMID:9723970
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding
EXP
Loxapine analog binds to HTR2C protein; Loxapine binds to HTR2C protein
CTD
PMID:9723970
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Loxapine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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