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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:loxapine
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Accession:CHEBI:50841 term browser browse the term
Definition:A dibenzooxazepine that has formula C18H18ClN3O.
Synonyms:exact_synonym: 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine
 related_synonym: 2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine;   Cloxazepine;   Formula=C18H18ClN3O;   InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3;   InChIKey=XJGVXQDUIWGIRW-UHFFFAOYSA-N;   SMILES=CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12;   loxapina;   loxapinum;   oxilapine
 alt_id: CHEBI:50839;   CHEBI:6548
 xref: Beilstein:626753;   CAS:1977-10-2;   DrugBank:DB00408;   Drug_Central:1613;   KEGG:C07104;   KEGG:D02340;   LINCS:LSM-2881
 xref_mesh: MESH:D008152
 xref: Patent:NL6406089;   Patent:US3412193;   Patent:US3546226;   Wikipedia:Loxapine


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loxapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing ISO CYP2D6 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 results in increased metabolism of Loxapine CTD PMID:21826677 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Drd1 dopamine receptor D1 affects binding EXP Loxapine analog binds to DRD1 protein; Loxapine binds to DRD1 protein CTD PMID:9723970 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 affects binding EXP Loxapine analog binds to DRD2 protein; Loxapine binds to DRD2 protein CTD PMID:9723970 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP Loxapine analog binds to HTR1A protein; Loxapine binds to HTR1A protein CTD PMID:9723970 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects binding EXP Loxapine analog binds to HTR2A protein; Loxapine binds to HTR2A protein CTD PMID:9723970 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding EXP Loxapine analog binds to HTR2C protein; Loxapine binds to HTR2C protein CTD PMID:9723970 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Loxapine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        pharmacological role 19105
          neurotransmitter agent 16542
            dopaminergic agent 5388
              dopaminergic antagonist 1593
                loxapine 9
                  loxapine succinate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic molecule 19835
                              organic cyclic compound 19589
                                organic heterocyclic compound 18857
                                  organic heteropolycyclic compound 18256
                                    organic heterotricyclic compound 15585
                                      dibenzooxazepine 22
                                        loxapine 9
                                          loxapine succinate 0
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