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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor
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Accession:CHEBI:50788 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor which interferes with the action of 3beta-hydroxysteroid dehydrogenase (EC 1.1.1.210), a group of steroidogenic enzymes.
Synonyms:related_synonym: 3beta(or 20alpha)-hydroxysteroid dehydrogenase inhibitor;   3beta(or 20alpha)-hydroxysteroid dehydrogenase inhibitors;   3beta(or 20alpha)-hydroxysteroid:NADP(+) oxidoreductase inhibitor;   3beta(or 20alpha)-hydroxysteroid:NADP(+) oxidoreductase inhibitors;   3beta,20alpha-hydroxysteroid oxidoreductase inhibitor;   3beta,20alpha-hydroxysteroid oxidoreductase inhibitors;   3beta-HSD;   3beta-hydroxysteroid dehydrogenase;   3beta-hydroxysteroid dehydrogenase inhibitor;   EC 1.1.1.210 (3beta(or 20alpha)-hydroxysteroid dehydrogenase) inhibitors;   EC 1.1.1.210 inhibitor;   EC 1.1.1.210 inhibitors;   dehydrogenase, 3beta,20alpha-hydroxy steroid inhibitor;   dehydrogenase, 3beta,20alpha-hydroxy steroid inhibitors;   progesterone reductase inhibitor;   progesterone reductase inhibitors


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trilostane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein multiple interactions ISO trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]] CTD PMID:25461682 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased activity of CASP3 protein]] CTD PMID:25461682 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G ESR2 estrogen receptor 2 increases expression ISO trilostane results in increased expression of ESR2 mRNA CTD PMID:20981412 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112 		JBrowse link
G FGF9 fibroblast growth factor 9 multiple interactions EXP FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr13:21,671,073...21,704,498
Ensembl chr13:21,671,073...21,704,498 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,014...30,235,261 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity ISO trilostane results in decreased activity of HSD3B2 protein CTD PMID:21558439 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP [FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone; FGF9 protein inhibits the reaction [[FSHB protein co-treated with IGF1 protein co-treated with trilostane] results in increased abundance of Pregnenolone] CTD PMID:22798350 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G POMC proopiomelanocortin decreases expression ISO trilostane results in decreased expression of POMC protein CTD PMID:19117688 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO trilostane inhibits the reaction [Trenbolone Acetate analog inhibits the reaction [Dihydrotestosterone results in increased expression of PSEN1 protein]] CTD PMID:25461682 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biochemical role 25162
          enzyme inhibitor 22343
            EC 1.* (oxidoreductase) inhibitor 19393
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 7706
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 6124
                  EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor 8
                    trilostane 9
paths to the root