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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor
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Accession:CHEBI:50781 term browser browse the term
Definition:An EC 1.3.1.* (oxidoreductase acting on CH-CH group of donor, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of of 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)), EC 1.3.1.22, the enzyme which converts testosterone (CHEBI:17347) into the more potent androgen 5alpha-dihydrotestosterone.
Synonyms:related_synonym: 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitor;   3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitors;   3-oxo-5alpha-steroid 4-dehydrogenase inhibitor;   3-oxo-5alpha-steroid 4-dehydrogenase inhibitors;   3-oxo-5alpha-steroid:NADP+ Delta(4)-oxidoreductase inhibitor;   3-oxo-5alpha-steroid:NADP+ Delta(4)-oxidoreductase inhibitors;   3-oxosteroid 5alpha-reductase inhibitor;   3-oxosteroid Delta4-dehydrogenase inhibitor;   4-ene-3-oxosteroid 5alpha-reductase inhibitor;   4-ene-5alpha-reductase inhibitor;   5alpha-oxidoreductase inhibitor;   5alpha-oxidoreductase inhibitors;   5alpha-reductase inhibitor;   5alpha-reductase inhibitors;   Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitor;   Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitors;   EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitors;   EC 1.3.1.22 inhibitor;   EC 1.3.1.22 inhibitors;   cholest-4-en-3-one 5alpha-reductase inhibitor;   cholestenone 5alpha-reductase inhibitor;   cholestenone 5alpha-reductase inhibitors;   reduced nicotinamide adenine dinucleotide phosphate:Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitor;   reduced nicotinamide adenine dinucleotide phosphate:Delta(4)-3-ketosteroid 5alpha-oxidoreductase inhibitors;   steroid 5alpha-hydrogenase inhibitor;   steroid 5alpha-hydrogenase inhibitors;   steroid 5alpha-reductase inhibitor;   steroid 5alpha-reductase inhibitors;   testosterone 5alpha-reductase inhibitor;   testosterone 5alpha-reductase inhibitors;   testosterone Delta(4)-5alpha-reductase inhibitor;   testosterone Delta(4)-5alpha-reductase inhibitors;   testosterone Delta(4)-hydrogenase inhibitor;   testosterone Delta(4)-hydrogenase inhibitors
 xref: Wikipedia:5-alpha-reductase_inhibitor



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  CHEBI ontology 5059
    role 5022
      biological role 5022
        biochemical role 4942
          enzyme inhibitor 492
            EC 1.* (oxidoreductase) inhibitor 110
              EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor 3
                EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor 2
                  EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor 0
                    3',4',5-trihydroxy-3,7-dimethoxyflavone 0
                    3',4',7-trihydroxyisoflavone 0
                    4-pregnen-20,21-diol-3-one 0
                    dutasteride 0
                    finasteride 0
                    impatienol 0
                    prunetin + 0
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