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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:appetite enhancer
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Accession:CHEBI:50779 term browser browse the term
Definition:A drug which increases appetite.
Synonyms:related_synonym: appetite enhancing drug;   appetite stimulant;   orexigenic
 xref: Wikipedia:Appetite_stimulants


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cannabigerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 increases expression ISO cannabigerol results in increased expression of ADCY5 mRNA CTD PMID:33019509 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy9 adenylate cyclase 9 decreases expression ISO cannabigerol results in decreased expression of ADCY9 mRNA CTD PMID:33019509 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression ISO cannabigerol results in increased expression of AKT1 mRNA CTD PMID:33019509 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO cannabigerol results in increased expression of ATF4 mRNA CTD PMID:33019509 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO cannabigerol results in increased expression of BCL2L1 mRNA CTD PMID:33019509 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO cannabigerol results in decreased expression of CAMK2B mRNA CTD PMID:33019509 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link
G Casp8 caspase 8 decreases expression ISO cannabigerol results in decreased expression of CASP8 mRNA CTD PMID:33019509 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:22971837 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Clock clock circadian regulator decreases expression ISO cannabigerol results in decreased expression of CLOCK mRNA CTD PMID:33019509 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218
JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO cannabigerol affects the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:22971837 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO cannabigerol results in decreased expression of CREB1 mRNA CTD PMID:33019509 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Dlgap1 DLG associated protein 1 increases expression ISO cannabigerol results in increased expression of DLGAP1 mRNA CTD PMID:33019509 NCBI chr 9:118,277,046...119,159,807
Ensembl chr 9:118,586,179...119,158,196
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO cannabigerol results in decreased expression of DRD2 mRNA CTD PMID:33019509 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases expression ISO cannabigerol results in decreased expression of EIF2AK3 mRNA CTD PMID:33019509 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO cannabigerol results in decreased expression of ERN1 mRNA CTD PMID:33019509 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Gnai2 G protein subunit alpha i2 increases expression ISO cannabigerol results in increased expression of GNAI2 mRNA CTD PMID:33019509 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnal G protein subunit alpha L decreases expression ISO cannabigerol results in decreased expression of GNAL mRNA CTD PMID:33019509 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
JBrowse link
G Gnb4 G protein subunit beta 4 increases expression ISO cannabigerol results in increased expression of GNB4 mRNA CTD PMID:33019509 NCBI chr 2:118,978,965...119,007,877
Ensembl chr 2:118,978,973...119,007,835
JBrowse link
G Hap1 huntingtin-associated protein 1 increases expression ISO cannabigerol results in increased expression of HAP1 mRNA CTD PMID:33019509 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:22971837 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22971837 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO cannabigerol results in decreased expression of MAP3K5 mRNA CTD PMID:33019509 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 decreases expression ISO cannabigerol results in decreased expression of PARP4 mRNA CTD PMID:33019509 NCBI chr15:36,809,362...36,911,167 JBrowse link
G Pld1 phospholipase D1 decreases expression ISO cannabigerol results in decreased expression of PLD1 mRNA CTD PMID:33019509 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
increases expression
ISO cannabigerol results in decreased expression of PPARG protein
cannabigerol results in increased expression of PPARG mRNA
CTD PMID:28853159 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression ISO cannabigerol results in decreased expression of PPP3R1 mRNA CTD PMID:33019509 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Prkca protein kinase C, alpha increases expression ISO cannabigerol results in increased expression of PRKCA mRNA CTD PMID:33019509 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta decreases expression ISO cannabigerol results in decreased expression of PRKCB mRNA CTD PMID:33019509 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 decreases expression ISO cannabigerol results in decreased expression of SHANK1 mRNA CTD PMID:33019509 NCBI chr 1:100,297,137...100,344,377
Ensembl chr 1:100,297,152...100,344,377
JBrowse link
G Slc18a1 solute carrier family 18 member A1 decreases expression ISO cannabigerol results in decreased expression of SLC18A1 mRNA CTD PMID:33019509 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression ISO cannabigerol results in decreased expression of SLC1A2 mRNA CTD PMID:33019509 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644
JBrowse link
G Slc32a1 solute carrier family 32 member 1 increases expression ISO cannabigerol results in increased expression of SLC32A1 mRNA CTD PMID:33019509 NCBI chr 3:155,102,980...155,107,815
Ensembl chr 3:155,103,150...155,107,817
JBrowse link
G Slc38a1 solute carrier family 38, member 1 decreases expression ISO cannabigerol results in decreased expression of SLC38A1 mRNA CTD PMID:33019509 NCBI chr 7:137,970,555...138,040,098
Ensembl chr 7:137,975,549...138,039,984
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP cannabigerol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22971837 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity
ISO [cannabigerol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
ghrelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA] CTD PMID:31468622 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Mir33 microRNA 33 multiple interactions EXP Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of MIR33A mRNA] CTD PMID:31468622 NCBI chr 7:123,431,612...123,431,680
Ensembl chr 7:123,431,612...123,431,680
JBrowse link
megestrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clu clusterin affects expression ISO Megestrol affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Megestrol affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Megestrol affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Megestrol results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ret ret proto-oncogene affects expression ISO Megestrol affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Megestrol affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
megestrol acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Megestrol Acetate results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ahsa1 activator of Hsp90 ATPase activity 1 increases expression ISO Megestrol Acetate results in increased expression of AHSA1 protein CTD PMID:16939895 NCBI chr 6:111,296,168...111,304,224
Ensembl chr 6:111,296,417...111,304,224
JBrowse link
G Ar androgen receptor multiple interactions ISO Megestrol Acetate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of BCL11B mRNA CTD PMID:22085904 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272
JBrowse link
G Cct6a chaperonin containing TCP1 subunit 6A increases expression ISO Megestrol Acetate results in increased expression of CCT6A protein CTD PMID:16939895 NCBI chr12:30,491,584...30,501,813
Ensembl chr12:30,491,416...30,501,860
JBrowse link
G Cldn1 claudin 1 multiple interactions
decreases expression
ISO Megestrol Acetate results in decreased expression of and affects the localization of CLDN1 protein
Megestrol Acetate results in decreased expression of CLDN1 mRNA
CTD PMID:22883527 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn4 claudin 4 multiple interactions
decreases expression
ISO Megestrol Acetate results in decreased expression of and results in increased localization of CLDN4 protein
Megestrol Acetate results in decreased expression of CLDN4 mRNA
CTD PMID:23095775 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Megestrol Acetate results in increased expression of COMT protein CTD PMID:16939895 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO ESR1 protein affects the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression
multiple interactions
ISO Megestrol Acetate results in increased expression of GREB1 mRNA
ESR1 protein affects the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA]; Fulvestrant inhibits the reaction [Megestrol Acetate results in increased expression of GREB1 mRNA]
CTD PMID:33405908 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Krt8 keratin 8 increases expression ISO Megestrol Acetate results in increased expression of KRT8 protein CTD PMID:16939895 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Mmp12 matrix metallopeptidase 12 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein CTD PMID:22085904 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein CTD PMID:22085904 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp8 matrix metallopeptidase 8 multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP8 protein CTD PMID:22085904 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Megestrol Acetate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppia peptidylprolyl isomerase A decreases expression ISO Megestrol Acetate results in decreased expression of PPIA protein CTD PMID:16939895 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Rab6a RAB6A, member RAS oncogene family increases expression ISO Megestrol Acetate results in increased expression of RAB6A protein CTD PMID:16939895 NCBI chr 1:165,624,973...165,664,201
Ensembl chr 1:165,625,058...165,664,192
JBrowse link
G Sf3a3 splicing factor 3a, subunit 3 increases expression ISO Megestrol Acetate results in increased expression of SF3A3 protein CTD PMID:16939895 NCBI chr 5:142,702,721...142,722,350
Ensembl chr 5:142,702,685...142,722,341
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO Megestrol Acetate results in increased expression of SGK1 mRNA
Fulvestrant inhibits the reaction [Megestrol Acetate results in increased expression of SGK1 mRNA]
CTD PMID:33405908 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Megestrol Acetate inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tnc tenascin C multiple interactions EXP [Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of TNC mRNA CTD PMID:22085904 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pharmaceutical 19304
          drug 19304
            appetite regulator 387
              appetite enhancer 65
                cannabigerol 35
                ghrelin 3
                megestrol + 27
                megestrol acetate 21
paths to the root