CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: etonogestrel
Accession: CHEBI:50777
browse the term
Definition: A terminal acetylenic compound that has formula C22H28O2.
Synonyms: exact_synonym: 17alpha-ethynyl-17beta-hydroxy-11-methylidene-18a-homo-estr-4-en-3-one
related_synonym: 3-Ketodesogestrel; 3-Oxodesogestrel; Formula=C22H28O2; Implanon; InChI=1S/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1; InChIKey=GCKFUYQCUCGESZ-BPIQYHPVSA-N; SMILES=[H][C@]12CCC(=O)C=C1CC[C@@]1([H])[C@]3([H])CC[C@@](O)(C#C)[C@@]3(CC)CC(=C)[C@]21[H]; etonogestrelum
xref: Beilstein:4237530; CAS:54048-10-1; DrugBank:DB00294; Drug_Central:1110; KEGG:D04104
xref_mesh: MESH:C044815
xref: Patent:EP51762; Patent:US4371529
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects metabolic processing
ISO
CYP3A4 protein affects the metabolism of etonogestrel
CTD
PMID:15963096
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
F2
coagulation factor II, thrombin
multiple interactions
EXP
etonogestrel promotes the reaction [F2 protein results in increased expression of F3 mRNA]
CTD
PMID:11733402
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
G
F2r
coagulation factor II (thrombin) receptor
multiple interactions increases expression
EXP
Mifepristone inhibits the reaction [etonogestrel results in increased expression of F2R mRNA]
CTD
PMID:11733402
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
G
F3
coagulation factor III, tissue factor
multiple interactions
EXP
etonogestrel promotes the reaction [F2 protein results in increased expression of F3 mRNA]
CTD
PMID:11733402
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Pgr
progesterone receptor
increases expression
ISO
etonogestrel results in increased expression of PGR protein
CTD
PMID:11041225
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all