The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
Synonyms:
related_synonym:
DNA gyrase inhibitor; DNA gyrase inhibitors; DNA topoisomerase (ATP-hydrolysing) inhibitor; DNA topoisomerase (ATP-hydrolysing) inhibitors; DNA topoisomerase II inhibitor; DNA topoisomerase II inhibitors; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors; EC 5.99.1.3 inhibitor; EC 5.99.1.3 inhibitors; inhibitor of type II topoisomerase; inhibitors of type II topoisomerase; topoisomerase II inhibitor; topoisomerase II inhibitors; type II DNA topoisomerase inhibitor; type II DNA topoisomerase inhibitors