Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
go back to main search page
Accession:CHEBI:50750 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
Synonyms:related_synonym: DNA gyrase inhibitor;   DNA gyrase inhibitors;   DNA topoisomerase (ATP-hydrolysing) inhibitor;   DNA topoisomerase (ATP-hydrolysing) inhibitors;   DNA topoisomerase II inhibitor;   DNA topoisomerase II inhibitors;   EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors;   EC 5.99.1.3 inhibitor;   EC 5.99.1.3 inhibitors;   inhibitor of type II topoisomerase;   inhibitors of type II topoisomerase;   topoisomerase II inhibitor;   topoisomerase II inhibitors;   type II DNA topoisomerase inhibitor;   type II DNA topoisomerase inhibitors
 alt_id: CHEBI:132229;   CHEBI:50234


show annotations for term's descendants           Sort by:
fisetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP [bisphenol A co-treated with fisetin] results in increased expression of CASP3 mRNA CTD PMID:29544186 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 multiple interactions EXP [bisphenol A co-treated with fisetin] results in decreased expression of CYP11A1 mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of CYP11A1 mRNA] CTD PMID:29544186 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP bisphenol A promotes the reaction [fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; fisetin promotes the reaction [bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]] CTD PMID:29544186 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274 		JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases expression		 EXP bisphenol A promotes the reaction [fisetin results in decreased expression of HSD3B1 mRNA]; fisetin promotes the reaction [bisphenol A results in decreased expression of HSD3B1 mRNA] CTD PMID:29544186 NCBI chr 4:101,565,229...101,574,110 JBrowse link
G STAR steroidogenic acute regulatory protein multiple interactions EXP [bisphenol A co-treated with fisetin] results in decreased expression of STAR mRNA; fisetin promotes the reaction [bisphenol A results in decreased expression of STAR mRNA] CTD PMID:29544186 NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,377,521...48,385,462 		JBrowse link
genistein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 decreases expression EXP Genistein results in decreased expression of ESR1 protein CTD PMID:22443950 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Genistein inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5066
    role 5030
      biological role 5030
        biochemical role 4951
          enzyme inhibitor 493
            EC 5.* (isomerase) inhibitor 15
              EC 5.99.* (other isomerases) inhibitor 11
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 11
                  topoisomerase inhibitor 11
                    EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor 9
                      (R)-temafloxacin + 0
                      (S)-temafloxacin + 0
                      4'-epidoxorubicin 0
                      4,4'-propane-1,3-diyldipiperazine-2,6-dione 0
                      ICRF-193 0
                      TOP-53 0
                      aclacinomycin A 0
                      aclacinomycin A zwitterion 0
                      amsacrine 0
                      betulinic acid + 0
                      celastrol 0
                      ciprofloxacin + 0
                      ciprofloxacin dihydrochloride 0
                      ciprofloxacin hydrochloride (anhydrous) + 0
                      ciprofloxacin hydrochloride hydrate 0
                      dextrofloxacin + 0
                      dihydrobetulinic acid 0
                      ellagic acid + 0
                      fisetin + 5
                      fleroxacin 0
                      flumequine 0
                      gatifloxacin + 0
                      genistein + 4
                      kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      levofloxacin + 0
                      lucanthone + 0
                      maleimide + 0
                      manoalide 0
                      methyl brevifolincarboxylate 0
                      nepalensinol D 0
                      nepalensinol E 0
                      nepalensinol F 0
                      novobiocin 0
                      ofloxacin 0
                      procyanidin B4 + 0
                      temafloxacin 0
                      teniposide 0
                      wedelolactone 0
paths to the root