Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
go back to main search page
Accession:CHEBI:50750 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
Synonyms:related_synonym: DNA gyrase inhibitor;   DNA gyrase inhibitors;   DNA topoisomerase (ATP-hydrolysing) inhibitor;   DNA topoisomerase (ATP-hydrolysing) inhibitors;   DNA topoisomerase II inhibitor;   DNA topoisomerase II inhibitors;   EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors;   EC 5.99.1.3 inhibitor;   EC 5.99.1.3 inhibitors;   inhibitor of type II topoisomerase;   inhibitors of type II topoisomerase;   topoisomerase II inhibitor;   topoisomerase II inhibitors;   type II DNA topoisomerase inhibitor;   type II DNA topoisomerase inhibitors
 alt_id: CHEBI:132229;   CHEBI:50234


show annotations for term's descendants           Sort by:
 





Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        biochemical role 19310
          enzyme inhibitor 18231
            EC 5.* (isomerase) inhibitor 6644
              EC 5.99.* (other isomerases) inhibitor 6463
                EC 5.99.1.* (miscellaneous isomerase) inhibitor 6463
                  topoisomerase inhibitor 6463
                    EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor 3880
                      (R)-temafloxacin + 0
                      (S)-temafloxacin + 0
                      4'-epidoxorubicin 52
                      4,4'-propane-1,3-diyldipiperazine-2,6-dione 0
                      ICRF-193 0
                      TOP-53 0
                      aclacinomycin A 12
                      aclacinomycin A zwitterion 0
                      amsacrine 28
                      betulinic acid + 50
                      celastrol 152
                      ciprofloxacin + 73
                      ciprofloxacin dihydrochloride 0
                      ciprofloxacin hydrochloride (anhydrous) + 0
                      ciprofloxacin hydrochloride hydrate 0
                      dihydrobetulinic acid 0
                      ellagic acid + 131
                      fisetin + 111
                      fleroxacin 0
                      flumequine 28
                      gatifloxacin + 4
                      genistein + 3585
                      kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
                      kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                      lucanthone + 195
                      maleimide + 77
                      manoalide 3
                      methyl brevifolincarboxylate 0
                      nepalensinol D 0
                      nepalensinol E 0
                      nepalensinol F 0
                      novobiocin 5
                      procyanidin B4 + 0
                      temafloxacin 0
                      teniposide 23
                      wedelolactone 17
paths to the root