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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC [DNA topoisomerase (ATP-hydrolysing)] inhibitor
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Accession:CHEBI:50750 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
Synonyms:related_synonym: DNA gyrase inhibitor;   DNA gyrase inhibitors;   DNA topoisomerase (ATP-hydrolysing) inhibitor;   DNA topoisomerase (ATP-hydrolysing) inhibitors;   DNA topoisomerase II inhibitor;   DNA topoisomerase II inhibitors;   EC [DNA topoisomerase (ATP-hydrolysing)] inhibitors;   EC inhibitor;   EC inhibitors;   inhibitor of type II topoisomerase;   inhibitors of type II topoisomerase;   topoisomerase II inhibitor;   topoisomerase II inhibitors;   type II DNA topoisomerase inhibitor;   type II DNA topoisomerase inhibitors
 alt_id: CHEBI:132229;   CHEBI:50234

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      CHEBI ontology 20056
        role 20008
          biological role 20007
            biochemical role 19640
              enzyme inhibitor 18571
                EC 5.* (isomerase) inhibitor 6684
                  EC 5.99.* (other isomerases) inhibitor 6502
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 6502
                      topoisomerase inhibitor 6502
                        EC [DNA topoisomerase (ATP-hydrolysing)] inhibitor 3897
                          (R)-temafloxacin + 0
                          (S)-temafloxacin + 0
                          4'-epidoxorubicin 53
                          4,4'-propane-1,3-diyldipiperazine-2,6-dione 0
                          ICRF-193 0
                          TOP-53 0
                          aclacinomycin A 12
                          aclacinomycin A zwitterion 0
                          amsacrine 28
                          betulinic acid + 53
                          celastrol 181
                          ciprofloxacin + 74
                          ciprofloxacin dihydrochloride 0
                          ciprofloxacin hydrochloride (anhydrous) + 0
                          ciprofloxacin hydrochloride hydrate 0
                          dihydrobetulinic acid 0
                          ellagic acid + 132
                          fisetin + 110
                          fleroxacin 1
                          flumequine 28
                          gatifloxacin + 5
                          genistein + 3591
                          kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-apiofuranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          lucanthone + 194
                          maleimide + 77
                          manoalide 3
                          methyl brevifolincarboxylate 0
                          nepalensinol D 0
                          nepalensinol E 0
                          nepalensinol F 0
                          novobiocin 5
                          procyanidin B4 + 0
                          temafloxacin 0
                          teniposide 23
                          wedelolactone 18
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