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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tricetin
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Accession:CHEBI:507499 term browser browse the term
Definition:Flavone hydroxylated at positions 3', 4', 5, 5' and 7.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
 related_synonym: 3',4',5,5',7-pentahydroxyflavone;   Formula=C15H10O7;   InChI=1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H;   InChIKey=ARSRJFRKVXALTF-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc(cc2=O)-c1cc(O)c(O)c(O)c1
 alt_id: CHEBI:44171;   CHEBI:9680
 xref: Beilstein:307745;   CAS:520-31-0;   DrugBank:DB08230;   KEGG:C10192;   KNApSAcK:C00013328;   LIPID_MAPS_instance:LMPK12110847
 xref_mesh: MESH:C469689
 xref: MetaCyc:CPD-12570;   PDBeChem:MYF;   PMID:12440738;   PMID:16730127;   PMID:19705844;   PMID:21067180;   PMID:23352409;   Reaxys:307745
 cyclic_relationship: is_conjugate_acid_of CHEBI:60045


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tricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX mRNA]; tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX protein] CTD PMID:31176653 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein] CTD PMID:31176653 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in increased expression of and results in increased activity of CASP3 protein] CTD PMID:31176653 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO tricetin results in increased expression of HMOX1 mRNA; tricetin results in increased expression of HMOX1 protein CTD PMID:31176653 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO tricetin results in increased expression of KEAP1 mRNA; tricetin results in increased expression of KEAP1 protein CTD PMID:31176653 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein] CTD PMID:31176653 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO tricetin results in decreased expression of MMP9 mRNA; tricetin results in decreased expression of MMP9 protein
tricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; tricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
CTD PMID:27860196 PMID:28731287 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO tricetin results in increased expression of and affects the localization of NFE2L2 protein
tricetin results in increased expression of NFE2L2 mRNA
CTD PMID:31176653 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO tricetin results in decreased expression of NQO1 mRNA CTD PMID:31176653 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions
ISO tricetin results in decreased activity of PARP1 protein
tricetin inhibits the reaction [Oxidopamine results in increased expression of PARP1 protein]
CTD PMID:17884996 PMID:31176653 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
3',5'-di-O-methyltricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16552572 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      biological role 19804
        biochemical role 19339
          metabolite 19319
            tricetin 11
              3',4',5'-O-trimethyltricetin 0
              3',5'-di-O-methyltricetin + 1
              3'-O-methyltricetin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  oxacycle 17279
                                    benzopyran 10142
                                      1-benzopyran 9858
                                        flavonoid 6375
                                          flavones 4170
                                            hydroxyflavone 4158
                                              pentahydroxyflavone 4009
                                                tricetin 11
                                                  3',4',5'-O-trimethyltricetin 0
                                                  3',5'-di-O-methyltricetin + 1
                                                  3'-O-methyltricetin + 0
paths to the root