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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tricetin
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Accession:CHEBI:507499 term browser browse the term
Definition:Flavone hydroxylated at positions 3', 4', 5, 5' and 7.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
 related_synonym: 3',4',5,5',7-pentahydroxyflavone;   Formula=C15H10O7;   InChI=1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H;   InChIKey=ARSRJFRKVXALTF-UHFFFAOYSA-N;   SMILES=Oc1cc(O)c2c(c1)oc(cc2=O)-c1cc(O)c(O)c(O)c1
 alt_id: CHEBI:44171;   CHEBI:9680
 xref: Beilstein:307745;   CAS:520-31-0;   DrugBank:DB08230;   KEGG:C10192;   KNApSAcK:C00013328;   LIPID_MAPS_instance:LMPK12110847
 xref_mesh: MESH:C469689
 xref: MetaCyc:CPD-12570;   PDBeChem:MYF;   PMID:12440738;   PMID:16730127;   PMID:19705844;   PMID:21067180;   PMID:23352409;   Reaxys:307745
 cyclic_relationship: is_conjugate_acid_of CHEBI:60045


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tricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX mRNA]; tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX protein] CTD PMID:31176653 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein] CTD PMID:31176653 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in increased expression of and results in increased activity of CASP3 protein] CTD PMID:31176653 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO tricetin results in increased expression of HMOX1 mRNA; tricetin results in increased expression of HMOX1 protein CTD PMID:31176653 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO tricetin results in increased expression of KEAP1 mRNA; tricetin results in increased expression of KEAP1 protein CTD PMID:31176653 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tricetin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein] CTD PMID:31176653 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO tricetin results in decreased expression of MMP9 mRNA; tricetin results in decreased expression of MMP9 protein
tricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; tricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]		 CTD PMID:27860196 PMID:28731287 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 ISO tricetin results in increased expression of and affects the localization of NFE2L2 protein
tricetin results in increased expression of NFE2L2 mRNA		 CTD PMID:31176653 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO tricetin results in decreased expression of NQO1 mRNA CTD PMID:31176653 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
multiple interactions		 ISO tricetin results in decreased activity of PARP1 protein
tricetin inhibits the reaction [Oxidopamine results in increased expression of PARP1 protein]		 CTD PMID:17884996 PMID:31176653 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
3',5'-di-O-methyltricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16552572 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            tricetin 11
              3',4',5'-O-trimethyltricetin 0
              3',5'-di-O-methyltricetin + 1
              3'-O-methyltricetin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  oxacycle 17688
                                    benzopyran 11213
                                      1-benzopyran 10951
                                        flavonoid 6575
                                          flavones 4220
                                            hydroxyflavone 4203
                                              pentahydroxyflavone 4044
                                                tricetin 11
                                                  3',4',5'-O-trimethyltricetin 0
                                                  3',5'-di-O-methyltricetin + 1
                                                  3'-O-methyltricetin + 0
paths to the root