CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tricetin
Accession: CHEBI:507499
browse the term
Definition: Flavone hydroxylated at positions 3', 4', 5, 5' and 7.
Synonyms: exact_synonym: 5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
related_synonym: 3',4',5,5',7-pentahydroxyflavone; Formula=C15H10O7; InChI=1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H; InChIKey=ARSRJFRKVXALTF-UHFFFAOYSA-N; SMILES=Oc1cc(O)c2c(c1)oc(cc2=O)-c1cc(O)c(O)c(O)c1
alt_id: CHEBI:44171; CHEBI:9680
xref: Beilstein:307745; CAS:520-31-0; DrugBank:DB08230; KEGG:C10192; KNApSAcK:C00013328; LIPID_MAPS_instance:LMPK12110847
xref_mesh: MESH:C469689
xref: MetaCyc:CPD-12570; PDBeChem:MYF; PMID:12440738; PMID:16730127; PMID:19705844; PMID:21067180; PMID:23352409; Reaxys:307745
cyclic_relationship: is_conjugate_acid_of CHEBI:60045
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX mRNA]; tricetin inhibits the reaction [Oxidopamine results in increased expression of BAX protein]
CTD
PMID:31176653
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 mRNA]; tricetin inhibits the reaction [Oxidopamine results in decreased expression of BCL2 protein]
CTD
PMID:31176653
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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Casp3
caspase 3
multiple interactions
ISO
tricetin inhibits the reaction [Oxidopamine results in increased expression of and results in increased activity of CASP3 protein]
CTD
PMID:31176653
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Hmox1
heme oxygenase 1
increases expression
ISO
tricetin results in increased expression of HMOX1 mRNA; tricetin results in increased expression of HMOX1 protein
CTD
PMID:31176653
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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Keap1
Kelch-like ECH-associated protein 1
increases expression
ISO
tricetin results in increased expression of KEAP1 mRNA; tricetin results in increased expression of KEAP1 protein
CTD
PMID:31176653
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
ISO
tricetin inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK8 protein]
CTD
PMID:31176653
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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Mmp9
matrix metallopeptidase 9
decreases expression multiple interactions
ISO
tricetin results in decreased expression of MMP9 mRNA; tricetin results in decreased expression of MMP9 protein tricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; tricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
CTD
PMID:27860196 PMID:28731287
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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Nfe2l2
nuclear factor, erythroid 2-like 2
multiple interactions increases expression
ISO
tricetin results in increased expression of and affects the localization of NFE2L2 protein tricetin results in increased expression of NFE2L2 mRNA
CTD
PMID:31176653
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
tricetin results in decreased expression of NQO1 mRNA
CTD
PMID:31176653
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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Parp1
poly (ADP-ribose) polymerase 1
decreases activity multiple interactions
ISO
tricetin results in decreased activity of PARP1 protein tricetin inhibits the reaction [Oxidopamine results in increased expression of PARP1 protein]
CTD
PMID:17884996 PMID:31176653
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
CTD
PMID:16552572
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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