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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiochromane
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Accession:CHEBI:50747 term browser browse the term
Definition:Any organic heterobicyclic compound consisting of a benzene ring fused to a thiopyran.
Synonyms:related_synonym: thiochromanes


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Ro 41-5253 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bco1 beta-carotene oxygenase 1 increases expression ISO Ro 41-5253 results in increased expression of BCO1 mRNA; Ro 41-5253 results in increased expression of BCO1 protein CTD PMID:16186334 NCBI chr19:49,637,059...49,673,577
Ensembl chr19:49,637,016...49,673,808
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]] CTD PMID:17209053 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]] CTD PMID:12421932 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd1d1 CD1d1 molecule multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] CTD PMID:17392484 NCBI chr 2:186,330,298...186,333,805
Ensembl chr 2:186,330,298...186,333,805
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]] CTD PMID:12421932 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] CTD PMID:10953040 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Ro 41-5253 results in increased expression of FABP4 mRNA CTD PMID:17290005 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions EXP Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of FTH1 mRNA] CTD PMID:22154532 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein] CTD PMID:16091010 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Ifng interferon gamma multiple interactions ISO Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of IFNG protein] CTD PMID:16007204 PMID:16872382 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] CTD PMID:16085646 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL10 protein] CTD PMID:16872382 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:16872382 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:16872382 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein] CTD PMID:16872382 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein CTD PMID:17290005 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ireb2 iron responsive element binding protein 2 multiple interactions EXP Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of IREB2 mRNA] CTD PMID:22154532 NCBI chr 8:59,450,974...59,503,634
Ensembl chr 8:59,420,123...59,501,118
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of IRF1 protein] CTD PMID:16085646 PMID:16636311 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions ISO Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein] CTD PMID:16007204 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] CTD PMID:17291456 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Oas2 2'-5' oligoadenylate synthetase 2 multiple interactions ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of OAS2 mRNA] CTD PMID:16636311 NCBI chr12:41,341,417...41,363,124
Ensembl chr12:41,340,815...41,363,161
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT] CTD PMID:7556191 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta affects binding
multiple interactions
ISO Ro 41-5253 binds to PPARD protein
Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein]
CTD PMID:17290005 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 binds to and results in increased activity of PPARG protein; Ro 41-5253 inhibits the reaction [pioglitazone results in increased activity of PPARG protein]; Ro 41-5253 inhibits the reaction [rosiglitazone binds to PPARG protein]
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 results in increased activity of and results in decreased expression of PPARG protein
CTD PMID:17290005 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions
decreases activity
increases response to substance
ISO Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]; Ro 41-5253 binds to and results in decreased activity of RARA protein; Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA]
RARA protein results in increased susceptibility to Ro 41-5253
CTD PMID:7556191 PMID:8838863 PMID:10779427 PMID:17216566 PMID:17290005 PMID:25550158 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] CTD PMID:25550158 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] CTD PMID:25550158 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]] CTD PMID:12421932 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] CTD PMID:25550158 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions
increases response to substance
decreases expression
ISO Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]
SLC10A1 protein results in increased susceptibility to Ro 41-5253
Ro 41-5253 results in decreased expression of SLC10A1 mRNA; Ro 41-5253 results in decreased expression of SLC10A1 protein
CTD PMID:25550158 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
decreases expression
ISO Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein]
Ro 41-5253 results in decreased expression of STAT1 protein
CTD PMID:16007204 PMID:16085646 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tfrc transferrin receptor multiple interactions EXP Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of TFRC mRNA] CTD PMID:22154532 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] CTD PMID:17291456 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
tazarotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tazarotene results in increased expression of BAX protein CTD PMID:16109552 PMID:16196285 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tazarotene results in decreased expression of BCL2 protein CTD PMID:16109552 PMID:16196285 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity ISO tazarotene results in increased activity of CASP3 protein CTD PMID:16196285 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tazarotene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression ISO tazarotene results in increased expression of SLC5A5 mRNA CTD PMID:16954431 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sts steroid sulfatase increases activity
multiple interactions
ISO tazarotene metabolite results in increased activity of STS protein; tazarotene results in increased activity of STS protein
wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]
CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
tazarotenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rarb retinoic acid receptor, beta multiple interactions ISO AGN 190299 binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO AGN 190299 binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Sts steroid sulfatase increases activity ISO AGN 190299 results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
tertatolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] CTD PMID:8539317 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B affects binding EXP tertatolol binds to HTR1B protein CTD PMID:11888550 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    chemical entity 19841
      atom 19839
        nonmetal atom 19720
          sulfur atom 16297
            sulfur molecular entity 16297
              organosulfur compound 15227
                organosulfur heterocyclic compound 5844
                  thiochromane 43
                    2-chloro-N-(7-methyl-9-oxo-2-thioxanthenyl)benzamide 0
                    3-[[4-(methylamino)-3-nitrophenyl]methylidene]-1-benzothiopyran-4-one 0
                    Meticrane 0
                    Ro 41-5253 33
                    tazarotene 11
                    tazarotenic acid + 11
                    tertatolol 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteropolycyclic compound 17874
                                    organic heterobicyclic compound 16808
                                      thiochromane 43
                                        2-chloro-N-(7-methyl-9-oxo-2-thioxanthenyl)benzamide 0
                                        3-[[4-(methylamino)-3-nitrophenyl]methylidene]-1-benzothiopyran-4-one 0
                                        Meticrane 0
                                        Ro 41-5253 33
                                        tazarotene 11
                                        tazarotenic acid + 11
                                        tertatolol 2
paths to the root