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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:progestogen
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Accession:CHEBI:50745 term browser browse the term
Definition:A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone.
Synonyms:related_synonym: gestagen;   gestagens;   progestagen;   progestagens;   progestogens


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progesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases secretion EXP AGT protein results in increased secretion of Progesterone CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833 		JBrowse link
G CRABP1 cellular retinoic acid binding protein 1 affects expression EXP Progesterone affects the expression of CRABP1 protein CTD PMID:11833939 NCBI chr 7:47,602,316...47,608,865
Ensembl chr 7:47,602,192...47,608,970 		JBrowse link
G CST3 cystatin C affects expression EXP Progesterone affects the expression of CST3 mRNA CTD PMID:20107207 NCBI chr17:30,471,056...30,474,486
Ensembl chr17:30,470,855...30,474,590 		JBrowse link
G CTSB cathepsin B increases expression EXP Progesterone results in increased expression of CTSB mRNA CTD PMID:20107207 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877 		JBrowse link
G CTSL cathepsin L increases expression EXP Progesterone results in increased expression of CTSL mRNA CTD PMID:20107207 NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618 		JBrowse link
G EGFR epidermal growth factor receptor affects chemical synthesis EXP EGFR protein affects the chemical synthesis of Progesterone CTD PMID:21520325 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Progesterone inhibits the reaction [estrone benzoate results in decreased expression of FGF2 mRNA] CTD PMID:15120423 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 multiple interactions
decreases expression 		EXP estrone benzoate inhibits the reaction [Progesterone results in decreased expression of FGFR1 mRNA alternative form] CTD PMID:15120423 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression
multiple interactions 		EXP Progesterone results in decreased expression of FGFR2 mRNA alternative form
[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of FGFR2 mRNA alternative form 		CTD PMID:15120423 PMID:15976484 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425 		JBrowse link
G FSHB follicle stimulating hormone subunit beta increases chemical synthesis
multiple interactions
increases abundance 		EXP FSHB protein results in increased chemical synthesis of Progesterone
4,4'-bisphenol F inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; [FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone; [FSHB protein co-treated with Lead co-treated with Mercury] results in decreased secretion of Progesterone; bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; bisphenol A promotes the reaction [fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; bisphenol AF inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; bisphenol S inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]; fisetin inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]; fisetin promotes the reaction [bisphenol A inhibits the reaction [FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone]]; FSHB protein results in increased chemical synthesis of and results in increased secretion of Progesterone; Lapatinib inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; Zearalenone promotes the reaction [FSHB protein results in increased abundance of Progesterone] 		CTD PMID:17656051 PMID:20390873 PMID:20965553 PMID:23375200 PMID:29544186 More... NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions
increases secretion
decreases secretion 		EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone]; GHRL protein results in decreased chemical synthesis of and results in decreased secretion of Progesterone; STAT1 protein inhibits the reaction [GHRL protein results in decreased secretion of Progesterone]
GHRL protein results in increased secretion of Progesterone 		CTD PMID:17904772 PMID:19528263 PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917 		JBrowse link
G HOXA10 homeobox A10 increases expression
multiple interactions 		EXP Progesterone results in increased expression of HOXA10 mRNA
Estradiol promotes the reaction [Progesterone results in increased expression of HOXA10 mRNA] 		CTD PMID:21705055 NCBI chr18:45,393,525...45,403,259
Ensembl chr18:45,393,885...45,403,257 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
increases abundance 		EXP [FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone; deoxynivalenol inhibits the reaction [[FSHB protein co-treated with IGF1 protein] results in increased abundance of Progesterone]; Zearalenone promotes the reaction [IGF1 protein results in increased abundance of Progesterone] CTD PMID:17656051 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G LEP leptin multiple interactions
increases secretion
increases expression 		EXP [TP53 protein co-treated with LEP protein] results in increased secretion of Progesterone
Progesterone results in increased secretion of LEP protein
Progesterone results in increased expression of LEP mRNA 		CTD PMID:22151798 PMID:23153703 NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323 		JBrowse link
G LHB luteinizing hormone subunit beta increases abundance
multiple interactions 		EXP LHB protein results in increased abundance of Progesterone
daidzein inhibits the reaction [LHB protein results in increased abundance of Progesterone]; Lapatinib inhibits the reaction [LHB protein results in increased abundance of Progesterone] 		CTD PMID:19617652 PMID:23375200 NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086 		JBrowse link
G OXT oxytocin/neurophysin I prepropeptide multiple interactions EXP Progesterone affects the reaction [OXT protein results in increased abundance of Calcium]; Progesterone inhibits the reaction [OXT protein results in increased abundance of Dinoprost]; Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprost]; Progesterone inhibits the reaction [OXT protein results in increased secretion of Dinoprostone]; Progesterone inhibits the reaction [OXT protein results in increased transport of Calcium] CTD PMID:16997130 PMID:21370738 NCBI chr17:32,605,586...32,606,449
Ensembl chr17:32,605,586...32,606,546 		JBrowse link
G PLAU plasminogen activator, urokinase increases expression EXP Progesterone results in increased expression of PLAU mRNA CTD PMID:23103014 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172 		JBrowse link
G POMC proopiomelanocortin increases secretion EXP POMC protein results in increased secretion of Progesterone CTD PMID:22100847 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418 		JBrowse link
G RBP4 retinol binding protein 4 affects expression EXP Progesterone affects the expression of RBP4 protein CTD PMID:11833939 NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP STAT1 protein inhibits the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:19528263 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260 		JBrowse link
G TP53 tumor protein p53 multiple interactions
decreases secretion 		EXP [TP53 protein co-treated with LEP protein] results in increased secretion of Progesterone
TP53 protein results in decreased secretion of Progesterone 		CTD PMID:22151798 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5403
    role 5372
      biological role 5372
        molecular messenger 539
          hormone 486
            sex hormone 463
              progestogen 21
                5alpha-pregnane-3,20-dione 0
                progestin + 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 5403
    role 5372
      biological role 5372
        pharmacological role 711
          agonist 583
            hormone 486
              sex hormone 463
                progestogen 21
                  5alpha-pregnane-3,20-dione 0
                  progestin + 21
paths to the root