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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyproterone acetate
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Accession:CHEBI:50743 term browser browse the term
Definition:A chlorinated steroid that has formula C24H29ClO4.
Synonyms:exact_synonym: 6-chloro-3,20-dioxo-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-4,6-dien-17-yl acetate
 related_synonym: Cyproterone 17-O-acetate;   Formula=C24H29ClO4;   InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1;   InChIKey=UWFYSQMTEOIJJG-FDTZYFLXSA-N;   SMILES=[H][C@@]12C[C@]1([H])[C@@]1(C)C(=CC2=O)C(Cl)=C[C@@]2([H])[C@]3([H])CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@]12[H];   acetic acid (8R,9S,10S,13S,14S,17R)-17-acetyl-6-(S)-chloro-10,13-dimethyl-3-(R)-oxo-1,2,3,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester
 alt_id: CHEBI:31451;   CHEBI:336019;   CHEBI:47297
 xref: Beilstein:2342172;   CAS:427-51-0;   DrugBank:DB04839;   Drug_Central:766;   KEGG:D01368
 xref_mesh: MESH:D017373
 xref: PDBeChem:CA4;   Patent:DE1189991;   Patent:US3234093;   Wikipedia:Cyproterone_Acetate


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cyproterone acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Apoa1 apolipoprotein A1 affects expression ISO Cyproterone Acetate affects the expression of APOA1 protein CTD PMID:16323982 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 affects expression ISO Cyproterone Acetate affects the expression of APOA2 protein CTD PMID:16323982 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Ar androgen receptor multiple interactions
increases response to substance
affects localization
decreases activity
affects binding
decreases expression
increases expression
ISO
EXP
[AR protein mutant form results in increased susceptibility to Cyproterone Acetate] which results in increased activity of AR protein mutant form; [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NFKBIB protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PGR protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRERF1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to UBE3A protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to AR protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BLOC1S1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CHD9 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CNOT1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to DHX30 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to ITGB3BP protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to KIF11 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MTA1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA3 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NRBF2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PNRC2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRAME protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 promoter]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 promoter]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOR1 protein binds to KLK3 promoter]; Cyproterone Acetate binds to and affects the folding of AR protein; Cyproterone Acetate binds to and results in decreased activity of AR protein; Cyproterone Acetate binds to and results in increased activity of AR protein; Cyproterone Acetate inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [Cadmium Chloride results in decreased expression of AR protein]; Cyproterone Acetate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]; NCOA1 protein results in increased activity of [Cyproterone Acetate binds to AR protein]; PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Cyproterone Acetate results in increased expression of AR mRNA]
Cyproterone Acetate affects the localization of AR protein
Cyproterone Acetate results in decreased activity of AR protein
[Cyproterone Acetate binds to AR protein] which binds to KLK3 enhancer; [Cyproterone Acetate binds to AR protein] which binds to KLK3 promoter; Cyproterone Acetate binds to AR protein
Cyproterone Acetate results in decreased expression of AR mRNA
CTD PMID:10053169, PMID:11751618, PMID:14565775, PMID:14751673, PMID:15084347, PMID:15110108, PMID:15308689, PMID:15336702, PMID:15483189, PMID:15994225, PMID:17505938, PMID:17804755, PMID:18324785, PMID:21543282, PMID:23562765, PMID:27473015, PMID:28751236 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BLOC1S1 protein modified form] CTD PMID:28751236 NCBI chr 7:3,342,630...3,346,238
Ensembl chr 7:3,342,630...3,346,238
JBrowse link
G Brd8 bromodomain containing 8 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form] CTD PMID:28751236 NCBI chr18:27,375,645...27,423,989
Ensembl chr18:27,398,688...27,424,090
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR1 protein CTD PMID:10770211 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein CTD PMID:10770211 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CHD9 protein modified form] CTD PMID:28751236 NCBI chr19:17,364,969...17,517,757
Ensembl chr19:17,366,828...17,494,585
JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CNOT1 protein modified form] CTD PMID:28751236 NCBI chr19:9,668,186...9,761,605
Ensembl chr19:9,668,186...9,761,605
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 promoter] CTD PMID:15308689, PMID:28751236 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CRP protein CTD PMID:14557435 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CXCR3 protein CTD PMID:10770211 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Cyproterone Acetate results in increased expression of CYP2B10 mRNA CTD PMID:28541575 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Cyproterone Acetate results in increased expression of CYP2C55 mRNA CTD PMID:28541575 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Dhx30 DExH-box helicase 30 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to DHX30 protein modified form] CTD PMID:28751236 NCBI chr 8:118,160,315...118,194,674
Ensembl chr 8:118,160,299...118,187,791
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Cyproterone Acetate] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Cyproterone Acetate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein; Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of FSHB protein
Cyproterone Acetate results in decreased expression of FSHB protein
CTD PMID:11994349, PMID:16002536 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form] CTD PMID:28751236 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO Cyproterone Acetate inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA] CTD PMID:16496412 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Helz2 helicase with zinc finger 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form] CTD PMID:28751236 NCBI chr 3:176,730,024...176,744,382
Ensembl chr 3:176,731,769...176,744,377
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of IGF1 protein CTD PMID:16002536 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Cyproterone Acetate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein; Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to ITGB3BP protein modified form] CTD PMID:28751236 NCBI chr 5:118,476,410...118,541,928
Ensembl chr 5:118,476,430...118,673,780
JBrowse link
G Kif11 kinesin family member 11 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to KIF11 protein modified form] CTD PMID:28751236 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Kpna1 karyopherin subunit alpha 1 increases expression EXP Cyproterone Acetate results in increased expression of KPNA1 mRNA CTD PMID:16906019 NCBI chr11:67,652,573...67,717,180
Ensembl chr11:67,652,577...67,703,025
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression
increases expression
EXP Cyproterone Acetate results in decreased expression of KPNA2 mRNA
Cyproterone Acetate results in increased expression of KPNA2 mRNA
CTD PMID:16906019 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Kpna3 karyopherin subunit alpha 3 increases expression EXP Cyproterone Acetate results in increased expression of KPNA3 mRNA CTD PMID:16906019 NCBI chr15:41,696,356...41,770,112
Ensembl chr15:41,698,281...41,770,112
JBrowse link
G Kpna4 karyopherin subunit alpha 4 decreases expression EXP Cyproterone Acetate results in decreased expression of KPNA4 mRNA CTD PMID:16906019 NCBI chr 2:165,684,345...165,739,874
Ensembl chr 2:165,684,345...165,739,874
JBrowse link
G Kpna5 karyopherin subunit alpha 5 decreases expression EXP Cyproterone Acetate results in decreased expression of KPNA5 mRNA CTD PMID:16906019 NCBI chr20:32,509,573...32,573,591
Ensembl chr20:32,509,598...32,572,250
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
increases expression
ISO
EXP
Cyproterone Acetate results in decreased expression of LHB protein
Cyproterone Acetate inhibits the reaction [testosterone enanthate results in decreased expression of LHB protein]
Cyproterone Acetate results in increased expression of LHB protein
[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB protein
CTD PMID:11994349, PMID:16002536, PMID:20463352, PMID:23085480 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form] CTD PMID:28751236 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Men1 menin 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form] CTD PMID:28751236 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Mta1 metastasis associated 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MTA1 protein modified form] CTD PMID:28751236 NCBI chr 6:137,911,302...137,950,066
Ensembl chr 6:137,924,293...137,950,075
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Cyproterone Acetate] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO NCOA1 protein results in increased activity of [Cyproterone Acetate binds to AR protein] CTD PMID:17804755 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 promoter] CTD PMID:15308689, PMID:28751236 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA3 protein modified form] CTD PMID:28751236 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOR1 protein binds to KLK3 promoter] CTD PMID:15308689, PMID:28751236 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Cyproterone Acetate results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NFKBIB protein modified form] CTD PMID:28751236 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]
Cyproterone Acetate results in decreased expression of NOS2 mRNA
CTD PMID:20463352, PMID:23085480 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B1 protein modified form] CTD PMID:28751236 NCBI chr  X:54,734,385...54,738,513
Ensembl chr  X:54,734,385...54,738,513
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B2 protein modified form] CTD PMID:28751236 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Cyproterone Acetate results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NRBF2 protein modified form] CTD PMID:28751236 NCBI chr20:22,728,145...22,746,477
Ensembl chr20:22,728,208...22,746,474
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form] CTD PMID:28751236 NCBI chr11:14,658,225...14,742,478
Ensembl chr11:14,658,225...14,741,563
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Cyproterone Acetate results in increased expression of AR mRNA] CTD PMID:15994225 NCBI chr 7:2,979,587...2,987,055
Ensembl chr 7:2,979,588...2,987,055
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of PDE5A mRNA] CTD PMID:20463352 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pelp1 proline, glutamate and leucine rich protein 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form] CTD PMID:28751236 NCBI chr10:56,988,076...57,005,111
Ensembl chr10:56,988,052...57,005,272
JBrowse link
G Pgr progesterone receptor multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PGR protein modified form]; Cyproterone Acetate binds to and results in increased activity of PGR protein CTD PMID:20599585, PMID:28751236 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pnrc2 proline-rich nuclear receptor coactivator 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PNRC2 protein modified form] CTD PMID:28751236 NCBI chr 5:154,220,552...154,223,536
Ensembl chr 5:154,218,852...154,223,536
JBrowse link
G Pprc1 PPARG related coactivator 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form] CTD PMID:28751236 NCBI chr 1:265,809,892...265,826,319
Ensembl chr 1:265,809,754...265,826,306
JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRAME protein modified form] CTD PMID:28751236 NCBI chr  X:106,082,984...106,091,256
Ensembl chr  X:106,083,203...106,085,878
JBrowse link
G Prl prolactin multiple interactions ISO
EXP
[Cyproterone Acetate co-treated with Ethinyl Estradiol] results in decreased expression of PRL protein
Cyproterone Acetate inhibits the reaction [Testosterone results in decreased expression of PRL mRNA]
CTD PMID:3157511, PMID:25603467 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prlr prolactin receptor multiple interactions
increases expression
EXP [Cyproterone Acetate co-treated with Testosterone] results in increased expression of PRLR mRNA
Cyproterone Acetate results in increased expression of PRLR mRNA
CTD PMID:25603467 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of TFRC protein CTD PMID:16002536 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form] CTD PMID:28751236 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Trerf1 transcriptional regulating factor 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRERF1 protein modified form] CTD PMID:28751236 NCBI chr 9:15,653,230...15,881,695
Ensembl chr 9:15,655,735...15,700,312
JBrowse link
G Ube3a ubiquitin protein ligase E3A multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to UBE3A protein modified form] CTD PMID:28751236 NCBI chr 1:116,586,901...116,678,161
Ensembl chr 1:116,587,815...116,679,973
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        organic group 18495
          3-oxo-Delta(4)-steroid group 7935
            3-oxo-Delta(4) steroid 7935
              cyproterone acetate 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      ketone 16144
                                        oxyketone 8631
                                          alpha-oxyketone 8631
                                            alpha-hydroxy ketone 8631
                                              tertiary alpha-hydroxy ketone 8357
                                                cyproterone 64
                                                  cyproterone acetate 62
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.