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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cyproterone acetate
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Accession:CHEBI:50743 term browser browse the term
Definition:A steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas.
Synonyms:exact_synonym: 6-chloro-3,20-dioxo-1beta,2beta-dihydro-3'H-cyclopropa[1,2]pregna-4,6-dien-17-yl acetate
 related_synonym: (1R,3aS,3bR,7aR,8aS,8bS,8cS,10aS)-1-acetyl-5-chloro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate;   (1beta,2beta)-17-(acetyloxy)-6-chloro-1,2-dihydro-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione;   1,2alpha-methylene-6-chloro-17alpha-acetoxy-4,6-pregnadiene-3,20-dione;   1,2alpha-methylene-6-chloro-Delta(4,6)-pregnadien-17alpha-ol-3,20-dione acetate;   1,2alpha-methylene-6-chloro-pregna-4,6-diene-3,20-dione 17alpha-acetate;   17alpha-acetoxy-6-chloro-1alpha,2alpha-methylenepregna-4,6-diene-3,20-dione;   6-chloro-1,2alpha-methylene-17alpha-hydroxy-Delta(6)-progesterone acetate;   6-chloro-1,2alpha-methylene-6-dehydro-17alpha-hydroxyprogesterone acetate;   6-chloro-17-hydroxy-1alpha,2alpha-methylenepregna-4,6-diene-3,20-dione acetate;   Androcur;   Cyprostat;   Cyproterone 17-O-acetate;   Formula=C24H29ClO4;   InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1;   InChIKey=UWFYSQMTEOIJJG-FDTZYFLXSA-N;   SH 714;   SMILES=[H][C@@]12C[C@]1([H])[C@@]1(C)C(=CC2=O)C(Cl)=C[C@@]2([H])[C@]3([H])CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@]12[H];   acetic acid (8R,9S,10S,13S,14S,17R)-17-acetyl-6-(S)-chloro-10,13-dimethyl-3-(R)-oxo-1,2,3,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester;   cyproterone 17alpha-acetate
 alt_id: CHEBI:31451;   CHEBI:336019;   CHEBI:47297
 xref: Beilstein:2342172;   CAS:427-51-0;   Chemspider:9496;   DrugBank:DB04839;   Drug_Central:766;   KEGG:D01368
 xref_mesh: MESH:D017373
 xref: PDBeChem:CA4;   PMCID:PMC7208009;   PMID:11393581;   PMID:11551428;   PMID:14583927;   PMID:15063071;   PMID:16372511;   PMID:17167851;   PMID:17311914;   PMID:24134630;   PMID:30666456;   PMID:31197615;   PMID:31634588;   PMID:31815317;   PMID:32418729;   PMID:33055297;   PMID:33081822;   PMID:33392938;   PMID:33394263;   PMID:33536184;   PMID:33750846;   PMID:33989640;   PMID:34125226;   PMID:34176757;   PMID:34187864;   PMID:34196865;   PMID:34274044;   PMID:34592677;   PMID:34613529;   Patent:DE1189991;   Patent:US3234093;   Wikipedia:Cyproterone_Acetate



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cyproterone acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein] CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Apoa1 apolipoprotein A1 affects expression ISO Cyproterone Acetate affects the expression of APOA1 protein CTD PMID:16323982 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 affects expression ISO Cyproterone Acetate affects the expression of APOA2 protein CTD PMID:16323982 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Ar androgen receptor multiple interactions
increases response to substance
affects localization
decreases activity
affects binding
decreases expression
increases expression
ISO
EXP
[AR protein mutant form results in increased susceptibility to Cyproterone Acetate] which results in increased activity of AR protein mutant form; [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NFKBIB protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PGR protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRERF1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to UBE3A protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to AR protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BLOC1S1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CHD9 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CNOT1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to DHX30 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to ITGB3BP protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to KIF11 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MTA1 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA3 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NRBF2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PNRC2 protein modified form]; [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRAME protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 promoter]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 promoter]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOR1 protein binds to KLK3 promoter]; Cyproterone Acetate binds to and affects the folding of AR protein; Cyproterone Acetate binds to and results in decreased activity of AR protein; Cyproterone Acetate binds to and results in increased activity of AR protein; Cyproterone Acetate inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [[Dihydrotestosterone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [[Metribolone binds to and results in increased activity of AR protein] which results in increased expression of KLK3 protein]; Cyproterone Acetate inhibits the reaction [Cadmium Chloride results in decreased expression of AR protein]; Cyproterone Acetate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Cyproterone Acetate inhibits the reaction [Metribolone results in increased activity of AR protein]; Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]; NCOA1 protein results in increased activity of [Cyproterone Acetate binds to AR protein]; PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Cyproterone Acetate results in increased expression of AR mRNA]
Cyproterone Acetate affects the localization of AR protein
Cyproterone Acetate results in decreased activity of AR protein
[Cyproterone Acetate binds to AR protein] which binds to KLK3 enhancer; [Cyproterone Acetate binds to AR protein] which binds to KLK3 promoter; Cyproterone Acetate binds to AR protein
Cyproterone Acetate results in decreased expression of AR mRNA
CTD PMID:10053169 PMID:11751618 PMID:14565775 PMID:14751673 PMID:15084347 More... NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bloc1s1 biogenesis of lysosomal organelles complex-1, subunit 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BLOC1S1 protein modified form] CTD PMID:28751236 NCBI chr 7:1,347,495...1,351,103
Ensembl chr 7:1,340,934...1,351,558
JBrowse link
G Brd8 bromodomain containing 8 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to BRD8 protein modified form] CTD PMID:28751236 NCBI chr18:26,181,744...26,230,035
Ensembl chr18:26,181,732...26,229,884
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR1 protein CTD PMID:10770211 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CCR5 protein CTD PMID:10770211 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Chd9 chromodomain helicase DNA binding protein 9 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CHD9 protein modified form] CTD PMID:28751236 NCBI chr19:15,941,535...16,146,220
Ensembl chr19:15,942,687...16,164,556
JBrowse link
G Cnot1 CCR4-NOT transcription complex, subunit 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CNOT1 protein modified form] CTD PMID:28751236 NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to CREBBP protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [CREBBP protein binds to KLK3 promoter] CTD PMID:15308689 PMID:28751236 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crp C-reactive protein multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CRP protein CTD PMID:14557435 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in increased expression of CXCR3 protein CTD PMID:10770211 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Cyproterone Acetate results in decreased activity of CYP1A1 protein CTD PMID:34181028 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Cyproterone Acetate results in increased expression of CYP2B10 mRNA CTD PMID:28541575 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Cyproterone Acetate results in increased expression of CYP2C55 mRNA CTD PMID:28541575 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Cyproterone Acetate results in increased expression of CYP3A4 mRNA CTD PMID:12505310 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dhx30 DExH-box helicase 30 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to DHX30 protein modified form] CTD PMID:28751236 NCBI chr 8:110,064,751...110,096,954
Ensembl chr 8:110,064,752...110,097,381
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with Cyproterone Acetate] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to EP300 protein modified form] CTD PMID:28751236 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Cyproterone Acetate binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Cyproterone Acetate binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Cyproterone Acetate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein; Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
decreases expression
ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of FSHB protein
Cyproterone Acetate results in decreased expression of FSHB protein
CTD PMID:11994349 PMID:16002536 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to GNAQ protein modified form] CTD PMID:28751236 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions ISO Cyproterone Acetate inhibits the reaction [Testosterone results in increased expression of GREB1 mRNA] CTD PMID:16496412 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
JBrowse link
G Helz2 helicase with zinc finger 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to HELZ2 protein modified form] CTD PMID:28751236 NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of IGF1 protein CTD PMID:16002536 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Cyproterone Acetate co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein; Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein]; Cyproterone Acetate inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein] CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itgb3bp integrin subunit beta 3 binding protein multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to ITGB3BP protein modified form] CTD PMID:28751236 NCBI chr 5:114,460,217...114,525,538
Ensembl chr 5:114,460,221...114,525,704
JBrowse link
G Kif11 kinesin family member 11 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to KIF11 protein modified form] CTD PMID:28751236 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kpna1 karyopherin subunit alpha 1 increases expression EXP Cyproterone Acetate results in increased expression of KPNA1 mRNA CTD PMID:16906019 NCBI chr11:64,715,844...64,774,647
Ensembl chr11:64,717,563...64,774,623
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression
increases expression
EXP Cyproterone Acetate results in decreased expression of KPNA2 mRNA
Cyproterone Acetate results in increased expression of KPNA2 mRNA
CTD PMID:16906019 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Kpna3 karyopherin subunit alpha 3 increases expression EXP Cyproterone Acetate results in increased expression of KPNA3 mRNA CTD PMID:16906019 NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
JBrowse link
G Kpna4 karyopherin subunit alpha 4 decreases expression EXP Cyproterone Acetate results in decreased expression of KPNA4 mRNA CTD PMID:16906019 NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
JBrowse link
G Kpna5 karyopherin subunit alpha 5 decreases expression EXP Cyproterone Acetate results in decreased expression of KPNA5 mRNA CTD PMID:16906019 NCBI chr20:30,822,925...30,888,080
Ensembl chr20:30,822,935...30,888,078
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
increases expression
ISO
EXP
Cyproterone Acetate results in decreased expression of LHB protein
Cyproterone Acetate inhibits the reaction [testosterone enanthate results in decreased expression of LHB protein]
Cyproterone Acetate results in increased expression of LHB protein
[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB protein
CTD PMID:11994349 PMID:16002536 PMID:20463352 PMID:23085480 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MED1 protein modified form] CTD PMID:28751236 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
JBrowse link
G Men1 menin 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to MEN1 protein modified form] CTD PMID:28751236 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871
JBrowse link
G Mta1 metastasis associated 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to MTA1 protein modified form] CTD PMID:28751236 NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with Cyproterone Acetate] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO NCOA1 protein results in increased activity of [Cyproterone Acetate binds to AR protein] CTD PMID:17804755 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA2 protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 enhancer]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOA2 protein binds to KLK3 promoter] CTD PMID:15308689 PMID:28751236 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NCOA3 protein modified form] CTD PMID:28751236 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NCOR1 protein modified form]; [Cyproterone Acetate binds to AR protein] promotes the reaction [NCOR1 protein binds to KLK3 promoter] CTD PMID:15308689 PMID:28751236 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Cyproterone Acetate results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NFKBIB protein modified form] CTD PMID:28751236 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
EXP Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]
Cyproterone Acetate results in decreased expression of NOS2 mRNA
CTD PMID:20463352 PMID:23085480 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] affects the reaction [AR protein modified form binds to NR0B1 protein modified form] CTD PMID:28751236 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NR0B2 protein modified form] CTD PMID:28751236 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Cyproterone Acetate binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Cyproterone Acetate results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to NRBF2 protein modified form] CTD PMID:28751236 NCBI chr20:21,308,606...21,326,878
Ensembl chr20:21,308,576...21,326,818
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to NRIP1 protein modified form] CTD PMID:28751236 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
JBrowse link
G Pa2g4 proliferation-associated 2G4 multiple interactions ISO PA2G4 protein inhibits the reaction [Cyproterone Acetate promotes the reaction [Metribolone results in increased expression of AR mRNA]]; PA2G4 protein inhibits the reaction [Cyproterone Acetate results in increased expression of AR mRNA] CTD PMID:15994225 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of PDE5A mRNA] CTD PMID:20463352 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pelp1 proline, glutamate and leucine rich protein 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PELP1 protein modified form] CTD PMID:28751236 NCBI chr10:55,094,798...55,111,833
Ensembl chr10:55,094,796...55,111,994
JBrowse link
G Pgr progesterone receptor multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PGR protein modified form]; Cyproterone Acetate binds to and results in increased activity of PGR protein CTD PMID:20599585 PMID:28751236 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pnrc2 proline-rich nuclear receptor coactivator 2 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PNRC2 protein modified form] CTD PMID:28751236 NCBI chr 5:148,103,966...148,106,950
Ensembl chr 5:148,095,699...148,107,242
Ensembl chr 5:148,095,699...148,107,242
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Cyproterone Acetate binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pprc1 PPARG related coactivator 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PPRC1 protein modified form] CTD PMID:28751236 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] promotes the reaction [AR protein modified form binds to PRAME protein modified form] CTD PMID:28751236 NCBI chr  X:98,567,994...98,574,654
Ensembl chr  X:98,569,415...98,572,096
JBrowse link
G Prl prolactin multiple interactions ISO
EXP
[Cyproterone Acetate co-treated with Ethinyl Estradiol] results in decreased expression of PRL protein
Cyproterone Acetate inhibits the reaction [Testosterone results in decreased expression of PRL mRNA]
CTD PMID:3157511 PMID:25603467 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prlr prolactin receptor multiple interactions
increases expression
EXP [Cyproterone Acetate co-treated with Testosterone] results in increased expression of PRLR mRNA
Cyproterone Acetate results in increased expression of PRLR mRNA
CTD PMID:25603467 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of TFRC protein CTD PMID:16002536 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TGFB1I1 protein modified form] CTD PMID:28751236 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
JBrowse link
G Trerf1 transcriptional regulating factor 1 multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to TRERF1 protein modified form] CTD PMID:28751236 NCBI chr 9:13,631,619...13,858,326
Ensembl chr 9:13,634,126...13,857,029
JBrowse link
G Ube3a ubiquitin protein ligase E3A multiple interactions ISO [Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to UBE3A protein modified form] CTD PMID:28751236 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      group 19717
        organic group 18713
          3-oxo-Delta(4)-steroid group 9121
            3-oxo-Delta(4) steroid 9121
              cyproterone acetate 68
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      ketone 16955
                                        oxyketone 8674
                                          alpha-oxyketone 8674
                                            alpha-hydroxy ketone 8674
                                              tertiary alpha-hydroxy ketone 8378
                                                cyproterone 72
                                                  cyproterone acetate 68
paths to the root