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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:montelukast
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Accession:CHEBI:50730 term browser browse the term
Definition:An aliphatic sulfide that has formula 586.18398.
Synonyms:exact_synonym: {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
 related_synonym: (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid;   1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid;   Formula=C35H36ClNO3S;   InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1;   InChIKey=UCHDWCPVSPXUMX-TZIWLTJVSA-N;   SMILES=CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC1)CC(O)=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1
 alt_id: CHEBI:49756;   CHEBI:6992
 xref: Beilstein:7896575;   CAS:158966-92-8;   DrugBank:DB00471;   Drug_Central:1836;   KEGG:C07482;   KEGG:D08229
 xref_mesh: MESH:C093875
 xref: PDBeChem:MTK;   Patent:EP1886997;   Wikipedia:Montelukast
 cyclic_relationship: is_conjugate_acid_of CHEBI:49165


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montelukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; montelukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir] CTD PMID:19952419 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP montelukast inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:21381050 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen affects response to substance ISO AGT polymorphism affects the susceptibility to montelukast CTD PMID:21624492 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Alb albumin multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in decreased secretion of ALB protein]; montelukast inhibits the reaction [Prednisolone results in decreased secretion of ALB protein] CTD PMID:28902463 PMID:30276927 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects response to substance ISO ALOX5 gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO montelukast inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:27702591 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO montelukast inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:27702591 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO montelukast results in increased expression of BGLAP mRNA CTD PMID:19544365 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO
EXP		 montelukast results in increased expression of CASP3 protein
montelukast inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]
montelukast inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; montelukast inhibits the reaction [Prednisolone results in increased expression of CASP3 protein]; montelukast inhibits the reaction [Rotenone results in increased activity of CASP3 protein]		 CTD PMID:14633444 PMID:27702591 PMID:28902463 PMID:30222980 PMID:30276927 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP montelukast inhibits the reaction [Indomethacin results in increased activity of CAT protein]; montelukast inhibits the reaction [Prednisolone results in decreased activity of CAT protein] CTD PMID:17895592 PMID:30276927 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 montelukast inhibits the reaction [CCL2 protein results in increased abundance of Calcium]
montelukast inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of CCL2 protein]		 CTD PMID:16771778 PMID:28902463 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO montelukast results in increased expression of COL10A1 mRNA CTD PMID:19544365 NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494 		JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO montelukast results in increased expression of COL2A1 mRNA CTD PMID:19544365 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO montelukast results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO montelukast results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity		 ISO CYP2C8 protein results in increased metabolism of montelukast
montelukast results in decreased activity of CYP2C8 protein		 CTD PMID:15601807 PMID:17994679 PMID:19309152 PMID:19328226 PMID:21336516 More...
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions
decreases expression		 ISO
EXP		 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein]; montelukast binds to and results in decreased activity of CYSLTR1 protein; montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
montelukast results in decreased expression of CYSLTR1 mRNA
montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]; montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]
montelukast inhibits the reaction [Rotenone results in increased expression of CYSLTR1 mRNA]		 CTD PMID:9620942 PMID:10391245 PMID:10462554 PMID:10851239 PMID:11006272 More... NCBI chr  X:71,661,421...71,690,012
Ensembl chr  X:71,663,821...71,690,121 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO montelukast binds to and results in decreased activity of CYSLTR2 protein; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in increased secretion of EDN1 protein] CTD PMID:28902463 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO montelukast results in increased expression of FAS protein CTD PMID:14633444 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gpr17 G protein-coupled receptor 17 multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased activity of GPR17 protein] CTD PMID:18974869 NCBI chr18:23,576,232...23,583,153
Ensembl chr18:23,577,242...23,582,966 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein] CTD PMID:28902463 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:30696844 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 montelukast inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
montelukast inhibits the reaction [Rotenone results in increased expression of IL1B protein]		 CTD PMID:27702591 PMID:30222980 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:30696844 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression		 ISO [montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein; [montelukast co-treated with desloratadine] results in decreased expression of IL5 protein
montelukast results in decreased expression of IL5 mRNA
montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]		 CTD PMID:14619337 PMID:15061398 PMID:30696844 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein] CTD PMID:19118273 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lta4h leukotriene A4 hydrolase affects response to substance ISO LTA4H gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase affects response to substance ISO LTC4S gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects expression ISO montelukast affects the expression of MAPK1 protein modified form CTD PMID:18059327 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects expression ISO montelukast affects the expression of MAPK3 protein modified form CTD PMID:18059327 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP montelukast inhibits the reaction [Indomethacin results in increased activity of MPO protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:11698051 PMID:17895592 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP montelukast inhibits the reaction [Prednisolone results in increased expression of NOS2 protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:11698051 PMID:30276927 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO montelukast results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO montelukast results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression ISO montelukast affects the expression of PTGS2 protein CTD PMID:18059327 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 montelukast inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein]
montelukast inhibits the reaction [Rotenone results in increased expression of RELA protein]		 CTD PMID:27702591 PMID:30222980 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO montelukast results in decreased expression of RNASE3 protein CTD PMID:10588996 NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO montelukast results in increased expression of RUNX2 mRNA CTD PMID:19544365 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP montelukast inhibits the reaction [Rotenone results in increased expression of TH protein] CTD PMID:30222980 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression		 ISO
EXP		 montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]
montelukast affects the expression of TNF protein
montelukast inhibits the reaction [Streptozocin results in increased expression of TNF protein]
montelukast inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of TNF protein]; montelukast inhibits the reaction [Rotenone results in increased expression of TNF protein]		 CTD PMID:18059327 PMID:19118273 PMID:27702591 PMID:28902463 PMID:30222980 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP montelukast inhibits the reaction [Rotenone results in increased expression of TP53 mRNA] CTD PMID:30222980 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        anti-asthmatic agent 9302
          anti-asthmatic drug 8678
            montelukast 45
              montelukast nitrile 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      monocarboxylic acid 17966
                                        montelukast 45
                                          montelukast nitrile 0
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