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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:montelukast
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Accession:CHEBI:50730 term browser browse the term
Definition:An aliphatic sulfide that has formula 586.18398.
Synonyms:exact_synonym: {1-[({(1R)-1-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl}sulfanyl)methyl]cyclopropyl}acetic acid
 related_synonym: (R-(E))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid;   1-[[[(1 R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid;   Formula=C35H36ClNO3S;   InChI=1S/C35H36ClNO3S/c1-34(2,40)30-9-4-3-7-25(30)13-17-32(41-23-35(18-19-35)22-33(38)39)27-8-5-6-24(20-27)10-15-29-16-12-26-11-14-28(36)21-31(26)37-29/h3-12,14-16,20-21,32,40H,13,17-19,22-23H2,1-2H3,(H,38,39)/b15-10+/t32-/m1/s1;   InChIKey=UCHDWCPVSPXUMX-TZIWLTJVSA-N;   SMILES=CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC1)CC(O)=O)c1cccc(\\C=C\\c2ccc3ccc(Cl)cc3n2)c1
 alt_id: CHEBI:49756;   CHEBI:6992
 xref: Beilstein:7896575;   CAS:158966-92-8;   DrugBank:DB00471;   Drug_Central:1836;   KEGG:C07482;   KEGG:D08229
 xref_mesh: MESH:C093875
 xref: PDBeChem:MTK;   Patent:EP1886997;   Wikipedia:Montelukast
 cyclic_relationship: is_conjugate_acid_of CHEBI:49165


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montelukast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects response to substance ISO ABCC1 gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO montelukast inhibits the reaction [ABCC2 protein results in increased export of calcein AM]; montelukast inhibits the reaction [ABCC2 protein results in increased export of Paclitaxel]; montelukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir] CTD PMID:19952419 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP montelukast inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:21381050 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen affects response to substance ISO AGT polymorphism affects the susceptibility to montelukast CTD PMID:21624492 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Alb albumin multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in decreased secretion of ALB protein]; montelukast inhibits the reaction [Prednisolone results in decreased secretion of ALB protein] CTD PMID:28902463, PMID:30276927 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects response to substance ISO ALOX5 gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO montelukast inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:27702591 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO montelukast inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:27702591 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression ISO montelukast results in increased expression of BGLAP mRNA CTD PMID:19544365 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO
EXP
montelukast results in increased expression of CASP3 protein
montelukast inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; montelukast inhibits the reaction [Prednisolone results in increased expression of CASP3 protein]; montelukast inhibits the reaction [Rotenone results in increased activity of CASP3 protein]
montelukast inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]
CTD PMID:14633444, PMID:27702591, PMID:28902463, PMID:30222980, PMID:30276927 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP montelukast inhibits the reaction [Indomethacin results in increased activity of CAT protein]; montelukast inhibits the reaction [Prednisolone results in decreased activity of CAT protein] CTD PMID:17895592, PMID:30276927 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
montelukast inhibits the reaction [CCL2 protein results in increased abundance of Calcium]
montelukast inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of CCL2 protein]
CTD PMID:16771778, PMID:28902463 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Col10a1 collagen type X alpha 1 chain increases expression ISO montelukast results in increased expression of COL10A1 mRNA CTD PMID:19544365 NCBI chr20:41,180,295...41,190,664
Ensembl chr20:41,184,287...41,189,633
JBrowse link
G Col2a1 collagen type II alpha 1 chain increases expression ISO montelukast results in increased expression of COL2A1 mRNA CTD PMID:19544365 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
decreases activity
ISO CYP2C8 protein results in increased metabolism of montelukast
montelukast results in decreased activity of CYP2C8 protein
CTD PMID:15601807, PMID:17994679, PMID:19309152, PMID:19328226, PMID:21336516 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions
decreases expression
ISO
EXP
alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [montelukast binds to and results in decreased activity of CYSLTR1 protein]; montelukast binds to and results in decreased activity of CYSLTR1 protein; montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [[Uridine Diphosphate metabolite results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
montelukast inhibits the reaction [Rotenone results in increased expression of CYSLTR1 mRNA]
montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]; montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]
montelukast results in decreased expression of CYSLTR1 mRNA
CTD PMID:9620942, PMID:10391245, PMID:10462554, PMID:10851239, PMID:11006272, PMID:11996896, PMID:12853847, PMID:14718577, PMID:18651869, PMID:19544365, PMID:20083671, PMID:27702591, PMID:30222980 NCBI chr  X:77,671,028...77,700,491
Ensembl chr  X:77,674,150...77,700,269
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 multiple interactions ISO montelukast binds to and results in decreased activity of CYSLTR2 protein; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 NCBI chr15:54,903,290...54,941,742
Ensembl chr15:54,905,274...54,906,203
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in increased secretion of EDN1 protein] CTD PMID:28902463 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO montelukast results in increased expression of FAS protein CTD PMID:14633444 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Gpr17 G protein-coupled receptor 17 multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased activity of GPR17 protein] CTD PMID:18974869 NCBI chr18:24,733,306...24,739,194
Ensembl chr18:24,734,330...24,735,349
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP montelukast inhibits the reaction [Cisplatin results in increased expression of HMOX1 protein] CTD PMID:28902463 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il12a interleukin 12A multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 multiple interactions ISO montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:30696844 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
montelukast inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
montelukast inhibits the reaction [Rotenone results in increased expression of IL1B protein]
CTD PMID:27702591, PMID:30222980 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 multiple interactions ISO montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein] CTD PMID:30696844 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
ISO [montelukast co-treated with Cetirizine] results in decreased expression of IL5 protein; [montelukast co-treated with desloratadine] results in decreased expression of IL5 protein
montelukast inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein]
montelukast results in decreased expression of IL5 mRNA
CTD PMID:14619337, PMID:15061398, PMID:30696844 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein] CTD PMID:19118273 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lta4h leukotriene A4 hydrolase affects response to substance ISO LTA4H gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltc4s leukotriene C4 synthase affects response to substance ISO LTC4S gene SNP affects the susceptibility to montelukast CTD PMID:16293801 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects expression ISO montelukast affects the expression of MAPK1 protein modified form CTD PMID:18059327 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects expression ISO montelukast affects the expression of MAPK3 protein modified form CTD PMID:18059327 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP montelukast inhibits the reaction [Indomethacin results in increased activity of MPO protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:11698051, PMID:17895592 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP montelukast inhibits the reaction [Prednisolone results in increased expression of NOS2 protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:11698051, PMID:30276927 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO montelukast results in increased activity of NR1H4 protein CTD PMID:22414727 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO montelukast results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 affects expression ISO montelukast affects the expression of PTGS2 protein CTD PMID:18059327 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
montelukast inhibits the reaction [Streptozocin results in increased expression of and affects the localization of RELA protein]
montelukast inhibits the reaction [Rotenone results in increased expression of RELA protein]
CTD PMID:27702591, PMID:30222980 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rnase3 ribonuclease A family member 3 decreases expression ISO montelukast results in decreased expression of RNASE3 protein CTD PMID:10588996 NCBI chr15:28,216,744...28,217,614
Ensembl chr15:28,216,744...28,217,614
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO montelukast results in increased expression of RUNX2 mRNA CTD PMID:19544365 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP montelukast inhibits the reaction [Rotenone results in increased expression of TH protein] CTD PMID:30222980 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
ISO
EXP
montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]
montelukast inhibits the reaction [Cisplatin results in increased expression of and results in increased secretion of TNF protein]; montelukast inhibits the reaction [Rotenone results in increased expression of TNF protein]
montelukast inhibits the reaction [Streptozocin results in increased expression of TNF protein]
montelukast affects the expression of TNF protein
CTD PMID:18059327, PMID:19118273, PMID:27702591, PMID:28902463, PMID:30222980 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP montelukast inhibits the reaction [Rotenone results in increased expression of TP53 mRNA] CTD PMID:30222980 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        anti-asthmatic agent 9174
          anti-asthmatic drug 8548
            montelukast 43
              montelukast nitrile 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          montelukast 43
                                            montelukast nitrile 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.