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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:mitoxantrone
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Accession:CHEBI:50729 term browser browse the term
Definition:A dihydroxyanthraquinone that is 1,4-dihydroxy-9,10-anthraquinone which is substituted by 6-hydroxy-1,4-diazahexyl groups at positions 5 and 8.
Synonyms:exact_synonym: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione
 related_synonym: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE;   Formula=C22H28N4O6;   InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2;   InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N;   SMILES=OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12;   mitoxantrona;   mitoxantronum
 alt_id: CHEBI:43919;   CHEBI:6955
 xref: Beilstein:2795126;   CAS:65271-80-9;   DrugBank:DB01204;   Drug_Central:1821;   KEGG:C11195;   KEGG:D08224;   LINCS:LSM-2481
 xref_mesh: MESH:D008942
 xref: PDBeChem:MIX;   Patent:DE2835661;   Patent:US4197249;   Wikipedia:Mitoxantrone


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mitoxantrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 affects response to substance ISO ABCA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO Mitoxantrone results in increased expression of ABCB1 protein CTD PMID:15239124 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
affects response to substance
increases transport
multiple interactions
increases export
increases expression
decreases abundance
decreases response to substance
affects uptake
affects transport
increases response to substance		 ISO ABCG2 protein affects the export of Mitoxantrone
ABCG2 protein affects the susceptibility to Mitoxantrone
ABCG2 protein results in increased transport of Mitoxantrone
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [Folic Acid deficiency results in decreased susceptibility to Mitoxantrone]; [3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; [Folic Acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to Mitoxantrone; [GSK 1363089 results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; [Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone; [MLN 8237 affects the activity of ABCG2 protein] which affects the export of Mitoxantrone; [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased export of Mitoxantrone; ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Cadmium Chloride inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; chrysin inhibits the reaction [ABCG2 protein results in increased secretion of Mitoxantrone]; Clozapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Cyclosporine inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; desisobutyrylciclesonide inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 gene mutant form results in decreased susceptibility to Mitoxantrone]; Erlotinib Hydrochloride inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; GSK 1363089 inhibits the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Haloperidol inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; Lapatinib inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; Mometasone Furoate inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Novobiocin inhibits the reaction [[5-Methoxypsoralen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Novobiocin inhibits the reaction [[Methoxsalen results in decreased activity of ABCG2 protein] which results in decreased export of and results in increased abundance of Mitoxantrone]; Olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; oxfendazole inhibits the reaction [ABCG2 protein affects the transport of Mitoxantrone]; Paliperidone Palmitate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Porphyrins inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]; Protons promotes the reaction [ABCG2 protein results in decreased susceptibility to Mitoxantrone]; Quetiapine Fumarate inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 gene mutant form results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein affects the uptake of Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of and results in decreased susceptibility to Mitoxantrone]; tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Mitoxantrone results in increased expression of ABCG2 mRNA; Mitoxantrone results in increased expression of ABCG2 protein
ABCG2 protein results in decreased abundance of Mitoxantrone
ABCG2 protein results in increased susceptibility to Mitoxantrone		 CTD PMID:10606239 PMID:12869632 PMID:15239124 PMID:15640379 PMID:15695404 More... NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain decreases expression ISO Mitoxantrone results in decreased expression of ACADVL protein CTD PMID:34246718 NCBI chr10:55,231,558...55,236,786
Ensembl chr10:54,732,469...54,738,075 		JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 affects response to substance ISO ACSL3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:87,563,601...87,613,078
Ensembl chr 9:80,115,112...80,164,627 		JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression ISO Mitoxantrone results in decreased expression of ACTA1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr19:68,781,168...68,784,194
Ensembl chr19:51,883,715...51,886,742 		JBrowse link
G Actg2 actin gamma 2, smooth muscle affects response to substance ISO ACTG2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 affects response to substance ISO ADARB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:11,222,171...11,350,416
Ensembl chr20:11,222,583...11,350,852 		JBrowse link
G Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 affects response to substance ISO AGPAT5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:77,641,887...77,688,148
Ensembl chr16:70,943,135...70,985,560 		JBrowse link
G Ahcyl1 adenosylhomocysteinase-like 1 affects response to substance ISO AHCYL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:197,982,335...198,016,770
Ensembl chr 2:195,294,153...195,345,815 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects response to substance ISO ALDH2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Amotl1 angiomotin-like 1 affects response to substance ISO AMOTL1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 8:19,630,139...19,749,027
Ensembl chr 8:11,353,674...11,467,573 		JBrowse link
G Ank2 ankyrin 2 decreases expression ISO Mitoxantrone results in decreased expression of ANK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:218,052,555...218,628,414
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) affects response to substance ISO ASNS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Ass1 argininosuccinate synthase 1 affects response to substance ISO ASS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:35,144,765...35,194,632
Ensembl chr 3:14,747,368...14,796,903 		JBrowse link
G Atg5 autophagy related 5 decreases expression ISO Mitoxantrone results in decreased expression of ATG5 protein CTD PMID:36216988 NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Mitoxantrone results in decreased expression of ATM mRNA
Mitoxantrone results in increased phosphorylation of ATM protein
[Poly(ADP-ribose) Polymerase Inhibitors co-treated with Mitoxantrone] results in increased phosphorylation of ATM protein		 CTD PMID:22832221 PMID:29913208 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression ISO Mitoxantrone results in decreased expression of ATP1A2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha decreases expression ISO Mitoxantrone results in decreased expression of ATP5F1A protein CTD PMID:34246718 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Mitoxantrone results in decreased expression of ATP5F1B protein CTD PMID:34246718 NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma decreases expression ISO Mitoxantrone results in decreased expression of ATP5F1C protein CTD PMID:34246718 NCBI chr17:73,333,584...73,355,872
Ensembl chr17:68,423,909...68,608,367 		JBrowse link
G Atp7a ATPase copper transporting alpha decreases response to substance ISO ATP7A protein results in decreased susceptibility to Mitoxantrone CTD PMID:17510416 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Bace2 beta-secretase 2 affects response to substance ISO BACE2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:50,176,852...50,258,948
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Mitoxantrone results in increased expression of BAX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbx BBX high mobility group box domain containing affects response to substance ISO BBX protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251 		JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) affects response to substance ISO BCAM protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 increases expression EXP Mitoxantrone results in increased expression of BCAT1 mRNA CTD PMID:23558518 NCBI chr 4:179,695,662...179,777,973
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]
Mitoxantrone results in decreased expression of BCL2 mRNA		 CTD PMID:8219202 PMID:8840993 PMID:15582267 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] CTD PMID:8840993 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 decreases expression ISO Mitoxantrone results in decreased expression of BECN1 protein CTD PMID:36216988 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Mitoxantrone results in decreased expression of BIRC2 protein CTD PMID:15359644 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects expression
increases expression		 ISO Mitoxantrone affects the expression of BIRC5 mRNA
Mitoxantrone results in increased expression of BIRC5 protein		 CTD PMID:16638212 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp7 bone morphogenetic protein 7 affects response to substance ISO BMP7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:182,059,318...182,135,273
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 affects response to substance ISO BST2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979 		JBrowse link
G Btbd3 BTB domain containing 3 affects response to substance ISO BTBD3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:125,591,427...125,621,660
Ensembl chr 3:125,591,490...125,619,038 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G decreases expression ISO Mitoxantrone results in decreased expression of CACNA1G mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 decreases expression ISO Mitoxantrone results in decreased expression of CACNA2D2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:116,950,860...117,082,159
Ensembl chr 8:108,072,454...108,203,173 		JBrowse link
G Calr calreticulin affects localization ISO Mitoxantrone affects the localization of CALR protein CTD PMID:20003823 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 affects response to substance ISO CAMK2N1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:155,958,116...155,959,897
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Casc3 CASC3 exon junction complex subunit affects response to substance ISO CASC3 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr10:83,769,014...83,788,966
Ensembl chr10:83,769,001...83,788,966 		JBrowse link
G Casp2 caspase 2 increases expression
increases splicing		 ISO Mitoxantrone results in increased expression of CASP2 mRNA alternative form
Mitoxantrone results in increased splicing of CASP2 mRNA		 CTD PMID:14757846 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO BCL2 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Mitoxantrone results in increased activity of CASP3 protein]		 CTD PMID:8840993 PMID:12948851 PMID:16215684 PMID:22700542 PMID:32894303 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp6 caspase 6 increases activity ISO Mitoxantrone results in increased activity of CASP6 protein CTD PMID:12948851 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Mitoxantrone results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein]		 CTD PMID:12948851 PMID:22700542 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases activity ISO Mitoxantrone results in increased activity of CASP8 protein CTD PMID:12948851 PMID:32894303 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity ISO Mitoxantrone results in increased activity of CASP9 protein CTD PMID:12948851 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase decreases activity EXP Mitoxantrone results in decreased activity of CAT protein CTD PMID:29913208 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cavin3 caveolae associated protein 3 affects response to substance ISO CAVIN3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:169,238,384...169,239,973
Ensembl chr 1:159,826,549...159,828,161 		JBrowse link
G Cavin4 caveolae associated protein 4 decreases expression ISO Mitoxantrone results in decreased expression of CAVIN4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:62,996,906...63,007,677
Ensembl chr 5:62,996,865...63,007,678 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) affects response to substance ISO CD55 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Celf2 CUGBP, Elav-like family member 2 affects response to substance ISO CELF2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333 		JBrowse link
G Cep15 centrosomal protein 15 affects response to substance ISO CEP15 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838 		JBrowse link
G Ces2h carboxylesterase 2H affects response to substance ISO CES2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chrdl1 chordin-like 1 affects response to substance ISO CHRDL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:106,889,125...106,992,937
Ensembl chr  X:106,889,125...106,992,921 		JBrowse link
G Cklf chemokine-like factor affects response to substance ISO CKLF protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:704,528...712,998
Ensembl chr19:698,033...706,570 		JBrowse link
G Ckm creatine kinase, M-type decreases expression ISO Mitoxantrone results in decreased expression of CKM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Clns1a chloride nucleotide-sensitive channel 1A affects response to substance ISO CLNS1A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:161,429,437...161,450,904
Ensembl chr 1:152,019,378...152,039,661 		JBrowse link
G Clu clusterin affects response to substance ISO CLU protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Coch cochlin affects response to substance ISO COCH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:74,766,485...74,780,504
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects response to substance ISO COL11A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:201,820,715...202,013,853 		JBrowse link
G Corin corin, serine peptidase decreases expression ISO Mitoxantrone results in decreased expression of CORIN mRNA CTD PMID:26537877 PMID:28940058 NCBI chr14:36,034,613...36,264,671
Ensembl chr14:35,681,304...35,909,503 		JBrowse link
G Cpvl carboxypeptidase, vitellogenic-like affects response to substance ISO CPVL protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:82,981,421...83,091,730
Ensembl chr 4:82,981,422...83,085,655 		JBrowse link
G Crebl2 cAMP responsive element binding protein-like 2 affects response to substance ISO CREBL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:167,673,359...167,699,299
Ensembl chr 4:167,673,315...167,699,292 		JBrowse link
G Cs citrate synthase decreases activity ISO Mitoxantrone results in decreased activity of CS protein CTD PMID:34246718 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421 		JBrowse link
G Csrnp2 cysteine and serine rich nuclear protein 2 affects response to substance ISO CSRNP2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 7:131,594,232...131,610,075
Ensembl chr 7:131,594,232...131,610,075 		JBrowse link
G Cth cystathionine gamma-lyase affects response to substance ISO CTH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule affects response to substance ISO CXADR protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:30,469,778...30,516,990
Ensembl chr11:16,982,860...17,030,046 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Mitoxantrone results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Mitoxantrone results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Dapk1 death associated protein kinase 1 affects response to substance ISO DAPK1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:3,935,826...4,096,858
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dhrs2 dehydrogenase/reductase 2 affects response to substance ISO DHRS2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:32,658,855...32,673,591
Ensembl chr15:28,688,940...28,703,644 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease affects response to substance ISO DIS3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:82,231,922...82,258,299
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Dmd dystrophin decreases expression ISO Mitoxantrone results in decreased expression of DMD mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:51,070,098...53,437,845
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Dusp4 dual specificity phosphatase 4 affects response to substance
increases expression		 ISO DUSP4 protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in increased expression of DUSP4 mRNA		 CTD PMID:16217747 PMID:26537877 PMID:28940058 NCBI chr16:64,079,893...64,101,396
Ensembl chr16:57,377,229...57,398,138 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 affects response to substance ISO DYRK2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:56,235,276...56,265,741
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Egr1 early growth response 1 affects response to substance ISO EGR1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects response to substance ISO EIF2S1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A affects response to substance ISO EIF5A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Elavl4 ELAV like RNA binding protein 4 affects response to substance ISO ELAVL4 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 5:130,285,418...130,429,106
Ensembl chr 5:125,056,848...125,200,446 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 affects response to substance ISO ELOVL5 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 8:87,671,164...87,737,618
Ensembl chr 8:78,790,846...78,857,284 		JBrowse link
G En2 engrailed homeobox 2 affects response to substance ISO EN2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:7,221,096...7,226,943
Ensembl chr 4:7,221,096...7,226,943 		JBrowse link
G Enc1 ectodermal-neural cortex 1 affects response to substance ISO ENC1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 affects response to substance ISO EPB41L2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:19,863,010...20,037,795
Ensembl chr 1:19,863,009...20,037,721 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases response to substance		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Mitoxantrone; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone] CTD PMID:21712253 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Mitoxantrone results in decreased expression of ERBB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression ISO Mitoxantrone results in decreased expression of ETFDH protein CTD PMID:34246718 NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:164,729,749...164,762,745 		JBrowse link
G Evi5 ecotropic viral integration site 5 affects response to substance ISO EVI5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678 		JBrowse link
G Extl2 exostosin-like glycosyltransferase 2 affects response to substance ISO EXTL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:203,922,217...203,946,940
Ensembl chr 2:203,922,187...203,943,653 		JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Mitoxantrone results in increased expression of FABP3 protein CTD PMID:22878004 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fam117a family with sequence similarity 117, member A affects response to substance ISO FAM117A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:80,281,411...80,325,345
Ensembl chr10:80,281,408...80,325,343 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Hydrocortisone promotes the reaction [Mitoxantrone results in increased expression of FAS]
Mitoxantrone results in increased expression of FAS mRNA; Mitoxantrone results in increased expression of FAS protein		 CTD PMID:9676859 PMID:26537877 PMID:28940058 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase decreases response to substance
multiple interactions		 ISO FASN protein results in decreased susceptibility to Mitoxantrone
orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]		 CTD PMID:18281512 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects response to substance ISO FDFT1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Mitoxantrone results in increased expression of FHL1 mRNA CTD PMID:23558518 NCBI chr  X:139,592,794...139,652,290
Ensembl chr  X:134,555,479...134,614,928 		JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects response to substance ISO FLRT3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:148,448,115...148,461,458
Ensembl chr 3:127,994,226...128,007,841 		JBrowse link
G Fndc3a fibronectin type III domain containing 3a affects response to substance ISO FNDC3A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:54,099,510...54,276,963
Ensembl chr15:47,689,919...47,866,784 		JBrowse link
G Foxf2 forkhead box F2 affects response to substance ISO FOXF2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr17:33,044,446...33,051,259
Ensembl chr17:32,836,777...32,842,176 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase affects response to substance ISO FYN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Fzd2 frizzled class receptor 2 affects response to substance ISO FZD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:88,061,988...88,063,898
Ensembl chr10:87,561,326...87,565,334 		JBrowse link
G Gch1 GTP cyclohydrolase 1 affects response to substance ISO GCH1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:22,884,006...22,917,412
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Mitoxantrone results in increased expression of GDF15 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Glul glutamate-ammonia ligase affects response to substance ISO GLUL protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Mitoxantrone results in increased expression of GPX1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 affects response to substance ISO GPX3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects response to substance ISO GUCY1B1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G H2ax H2A.X variant histone increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Mitoxantrone results in increased expression of H2AX protein
Mitoxantrone results in increased phosphorylation of H2AX protein
Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein]		 CTD PMID:19738048 PMID:24994473 PMID:29913208 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression ISO Mitoxantrone results in decreased expression of HADHB protein CTD PMID:34246718 NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:99,950,972...100,200,994
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hmg20b high mobility group 20 B affects response to substance ISO HMG20B protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640 		JBrowse link
G Hoxa5 homeo box A5 affects response to substance ISO HOXA5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:82,632,958...82,636,851
Ensembl chr 4:81,302,353...81,306,234 		JBrowse link
G Hrc histidine rich calcium binding protein decreases expression ISO Mitoxantrone results in decreased expression of HRC mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:95,813,262...95,816,987
Ensembl chr 1:95,813,253...95,816,984 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 affects response to substance ISO HSPA2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha affects response to substance
decreases expression		 ISO IDH3A protein affects the susceptibility to Mitoxantrone
Mitoxantrone results in decreased expression of IDH3A protein		 CTD PMID:16217747 PMID:34246718 NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 affects response to substance ISO IFITM1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:196,067,963...196,069,169 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects response to substance ISO IGF1R protein affects the susceptibility to Mitoxantrone CTD PMID:15499378 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 affects response to substance ISO IGF2BP3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:79,391,367...79,525,923
Ensembl chr 4:78,060,494...78,194,865 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects response to substance ISO IGFBP3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 affects response to substance ISO IGFBP7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:31,091,681...31,151,623
Ensembl chr14:30,737,164...30,797,314 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 affects response to substance ISO IL13RA2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:115,814,620...115,886,080
Ensembl chr  X:111,002,592...111,072,381 		JBrowse link
G Immt inner membrane mitochondrial protein decreases expression ISO Mitoxantrone results in decreased expression of IMMT protein CTD PMID:34246718 NCBI chr 4:105,438,657...105,477,370
Ensembl chr 4:103,880,459...103,919,109 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 affects response to substance ISO IQGAP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Irf7 interferon regulatory factor 7 affects response to substance ISO IRF7 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
G Irx1 iroquois homeobox 1 affects response to substance ISO IRX1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:33,123,122...33,128,951
Ensembl chr 1:31,294,615...31,300,444 		JBrowse link
G Irx4 iroquois homeobox 4 decreases expression ISO Mitoxantrone results in decreased expression of IRX4 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:30,030,561...30,039,549
Ensembl chr 1:30,030,561...30,039,549 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects response to substance ISO ISG15 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 affects response to substance ISO ISG20 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Mitoxantrone results in decreased expression of JAK2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in increased expression of JUN mRNA] CTD PMID:8219202 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 affects response to substance ISO KCNAB2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:168,182,228...168,270,760
Ensembl chr 5:162,901,896...162,988,243 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO Mitoxantrone results in decreased expression of KCNH2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 increases expression ISO Mitoxantrone results in increased expression of KCNJ2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr10:96,560,225...96,570,788
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 decreases expression ISO Mitoxantrone results in decreased expression of KCNQ1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:207,721,134...208,054,073
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Krr1 KRR1, small subunit processome component homolog affects response to substance ISO KRR1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985 		JBrowse link
G Lama2 laminin subunit alpha 2 affects response to substance ISO LAMA2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:19,492,126...20,140,056
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Lamb1 laminin subunit beta 1 affects response to substance ISO LAMB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:47,835,525...47,902,585 		JBrowse link
G Lamc1 laminin subunit gamma 1 affects response to substance ISO LAMC1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:67,924,872...68,051,986
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Lbh LBH regulator of WNT signaling pathway affects response to substance ISO LBH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:28,321,040...28,344,855
Ensembl chr 6:22,568,834...22,593,079 		JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Mitoxantrone results in decreased expression of LDB3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532 		JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 affects response to substance ISO LEMD2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626 		JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 affects response to substance ISO LGR4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:116,901,968...117,004,584
Ensembl chr 3:96,447,858...96,548,899 		JBrowse link
G Lipa lipase A, lysosomal acid type affects response to substance ISO LIPA protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633 		JBrowse link
G Lipg lipase G, endothelial type affects response to substance ISO LIPG protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 increases expression EXP Mitoxantrone results in increased expression of LMCD1 mRNA CTD PMID:23558518 NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:145,393,145...145,452,046 		JBrowse link
G Lmnb1 lamin B1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein CTD PMID:15582267 NCBI chr18:52,373,939...52,413,284
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 affects response to substance ISO MACROD1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:213,675,413...213,831,571
Ensembl chr 1:204,246,166...204,389,716 		JBrowse link
G Maff MAF bZIP transcription factor F affects response to substance ISO MAFF mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:110,912,499...110,923,851 		JBrowse link
G Maged1 MAGE family member D1 affects response to substance ISO MAGED1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:63,416,464...63,423,167
Ensembl chr  X:59,422,717...59,429,364 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Mitoxantrone results in decreased expression of and results in increased lipidation of MAP1LC3B protein CTD PMID:36216988 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mdh2 malate dehydrogenase 2 decreases expression ISO Mitoxantrone results in decreased expression of MDH2 protein CTD PMID:34246718 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Mdm2 MDM2 proto-oncogene decreases response to substance ISO MDM2 promoter SNP results in decreased susceptibility to Mitoxantrone CTD PMID:17575151 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mest mesoderm specific transcript affects response to substance ISO MEST protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:59,354,445...59,364,919
Ensembl chr 4:59,354,447...59,366,145 		JBrowse link
G Mocos molybdenum cofactor sulfurase affects response to substance ISO MOCOS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:16,206,402...16,251,928
Ensembl chr18:15,931,654...15,977,187 		JBrowse link
G Mpc2 mitochondrial pyruvate carrier 2 affects response to substance ISO MPC2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:77,728,176...77,747,664
Ensembl chr13:77,728,250...77,747,664 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase affects response to substance ISO MTHFD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 ISO Mitoxantrone results in decreased expression of MYC mRNA
Tetradecanoylphorbol Acetate promotes the reaction [Mitoxantrone results in decreased expression of MYC mRNA]		 CTD PMID:8219202 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mycbp2 MYC binding protein 2 affects response to substance ISO MYCBP2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:86,352,061...86,590,126
Ensembl chr15:79,937,354...80,175,498 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO Mitoxantrone results in decreased expression of MYH6 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr15:32,388,102...32,413,663
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 decreases expression ISO Mitoxantrone results in decreased expression of MYH7 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr15:32,416,525...32,439,851
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myom2 myomesin 2 decreases expression ISO Mitoxantrone results in decreased expression of MYOM2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase affects response to substance ISO NAMPT protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 affects response to substance ISO NDUFS5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:141,258,828...141,264,552
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603 		JBrowse link
G Nefh neurofilament heavy chain affects response to substance ISO NEFH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nid2 nidogen 2 affects response to substance ISO NID2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:4,507,224...4,562,949
Ensembl chr15:4,458,084...4,513,843 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases activity ISO Mitoxantrone results in decreased activity of NR3C1 protein CTD PMID:19255438 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 affects response to substance ISO NR4A2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Mitoxantrone results in decreased expression of NRAP mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:265,355,324...265,433,229
Ensembl chr 1:255,350,113...255,427,693 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 affects response to substance ISO NRIP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:28,382,835...28,466,483
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 affects response to substance ISO OXCT1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:54,963,964...55,112,303
Ensembl chr 2:53,236,368...53,384,714 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 affects response to substance ISO P4HA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G Pacrgl parkin coregulated like affects response to substance ISO PACRGL mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr14:62,532,019...62,556,977
Ensembl chr14:62,532,030...62,556,993 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; BCL2 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Mitoxantrone results in increased degradation of PARP1 protein] CTD PMID:8840993 PMID:15582267 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pbx1 PBX homeobox 1 affects response to substance ISO PBX1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:82,811,664...83,121,447
Ensembl chr13:80,278,770...80,588,594 		JBrowse link
G Pde4d phosphodiesterase 4D affects response to substance ISO PDE4D protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde8a phosphodiesterase 8A affects response to substance ISO PDE8A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression ISO Mitoxantrone results in decreased expression of PDHA1 protein CTD PMID:34246718 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Phb2 prohibitin 2 decreases expression ISO Mitoxantrone results in decreased expression of PHB2 protein CTD PMID:34246718 NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase affects response to substance ISO PHGDH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:188,595,700...188,624,789
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Plagl1 PLAG1 like zinc finger 1 affects response to substance ISO PLAGL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228 		JBrowse link
G Plat plasminogen activator, tissue type affects response to substance ISO PLAT protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plcb4 phospholipase C, beta 4 affects response to substance ISO PLCB4 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Plpbp pyridoxal phosphate binding protein affects response to substance ISO PLPBP protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:65,003,292...65,014,886
Ensembl chr16:65,002,223...65,014,886 		JBrowse link
G Pml PML nuclear body scaffold affects mutagenesis ISO Mitoxantrone affects the mutagenesis of PML gene CTD PMID:19884644 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 affects response to substance ISO PPP1R2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr11:82,977,634...82,999,426
Ensembl chr11:69,472,555...69,494,463 		JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A decreases expression ISO Mitoxantrone results in decreased expression of PPP1R3A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 4:43,905,648...43,946,236
Ensembl chr 4:42,939,599...42,980,638 		JBrowse link
G Prdm16 PR/SET domain 16 decreases expression ISO Mitoxantrone results in decreased expression of PRDM16 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 5:170,162,275...170,486,371
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Prdx2 peroxiredoxin 2 affects response to substance ISO PRDX2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:40,085,788...40,091,083
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prelid3b PRELI domain containing 3B affects response to substance ISO PRELID3B protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:183,681,257...183,689,253
Ensembl chr 3:163,262,985...163,271,181 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit increases expression ISO Mitoxantrone results in increased expression of PRKX mRNA CTD PMID:26537877 PMID:28940058 NCBI chr  X:45,701,747...45,745,210
Ensembl chr  X:41,823,355...41,866,669 		JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E affects response to substance ISO PTPRE protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:199,774,195...199,924,646
Ensembl chr 1:190,344,401...190,489,534 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Mitoxantrone results in decreased expression of PYGM mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Rara retinoic acid receptor, alpha affects mutagenesis ISO Mitoxantrone affects the mutagenesis of RARA gene CTD PMID:19884644 NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarb retinoic acid receptor, beta increases expression ISO Mitoxantrone results in increased expression of RARB mRNA alternative form CTD PMID:17608728 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rasa1 RAS p21 protein activator 1 affects response to substance ISO RASA1 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease affects response to substance ISO RBBP8 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:3,198,188...3,263,643
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rbm17 RNA binding motif protein 17 multiple interactions
decreases response to substance		 ISO LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]; Tamoxifen inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone] CTD PMID:16061639 NCBI chr17:71,846,941...71,863,834
Ensembl chr17:66,937,140...66,954,014 		JBrowse link
G Rcbtb1 RCC1 and BTB domain containing protein 1 affects response to substance ISO RCBTB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:37,430,453...37,477,920
Ensembl chr15:33,319,586...33,365,302 		JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 affects response to substance ISO RCHY1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:16,397,533...16,413,286
Ensembl chr14:16,113,224...16,129,167 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 affects response to substance ISO RGS2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rnd1 Rho family GTPase 1 increases expression EXP Mitoxantrone results in increased expression of RND1 mRNA CTD PMID:23558518 NCBI chr 7:131,700,321...131,707,392
Ensembl chr 7:129,821,311...129,828,399 		JBrowse link
G Rragd Ras-related GTP binding D affects response to substance ISO RRAGD mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356 		JBrowse link
G Runx3 RUNX family transcription factor 3 affects response to substance ISO RUNX3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:152,644,270...152,702,835
Ensembl chr 5:147,360,994...147,419,156 		JBrowse link
G Ryr2 ryanodine receptor 2 decreases expression ISO Mitoxantrone results in decreased expression of RYR2 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr17:63,081,527...63,667,141
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Sall2 spalt-like transcription factor 2 affects response to substance ISO SALL2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr15:27,494,831...27,512,402
Ensembl chr15:25,021,345...25,038,918 		JBrowse link
G Satb2 SATB homeobox 2 affects response to substance ISO SATB2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707 		JBrowse link
G Scd stearoyl-CoA desaturase affects response to substance ISO SCD protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Schip1 schwannomin interacting protein 1 affects response to substance ISO SCHIP1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 decreases expression ISO Mitoxantrone results in decreased expression of SCN2B mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:54,322,383...54,334,519
Ensembl chr 8:45,425,629...45,437,765 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases expression ISO Mitoxantrone results in decreased expression of SCN5A mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Sdc2 syndecan 2 affects response to substance ISO SDC2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081 		JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component affects response to substance ISO SEC31A protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Mitoxantrone results in increased expression of SERPINE1 mRNA CTD PMID:23558518 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sfn stratifin affects response to substance ISO SFN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sfrp4 secreted frizzled-related protein 4 affects response to substance ISO SFRP4 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr17:49,974,532...50,026,448
Ensembl chr17:45,234,097...45,330,736 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 affects response to substance ISO SLC16A6 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,426,244...94,448,779 		JBrowse link
G Slc25a11 solute carrier family 25 member 11 decreases expression ISO Mitoxantrone results in decreased expression of SLC25A11 protein CTD PMID:34246718 NCBI chr10:55,856,209...55,859,060
Ensembl chr10:55,357,597...55,360,410 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 affects response to substance ISO SLC7A5 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr19:66,843,808...66,872,412
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 affects response to substance ISO SLCO4A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 3:187,936,735...187,955,873
Ensembl chr 3:167,559,316...167,578,305 		JBrowse link
G Smad2 SMAD family member 2 affects response to substance ISO SMAD2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 affects response to substance ISO SORBS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:249,057,324...249,279,703
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Spon1 spondin 1 affects response to substance ISO SPON1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:177,363,526...177,662,689
Ensembl chr 1:167,928,972...168,228,226 		JBrowse link
G Spon2 spondin 2 affects response to substance ISO SPON2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:81,713,070...81,742,510
Ensembl chr14:77,511,901...77,517,996 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Mitoxantrone results in increased expression of SPP1 mRNA CTD PMID:23558518 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Sqstm1 sequestosome 1 affects expression
decreases expression		 ISO Mitoxantrone affects the expression of SQSTM1 protein
Mitoxantrone metabolite results in decreased expression of SQSTM1 protein		 CTD PMID:36216988 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 affects response to substance ISO SRD5A1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:35,514,914...35,548,898
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta decreases expression ISO Mitoxantrone results in decreased expression of SUCLA2 protein CTD PMID:34246718 NCBI chr15:55,161,894...55,215,031
Ensembl chr15:48,752,312...48,805,138 		JBrowse link
G Sytl2 synaptotagmin-like 2 affects response to substance ISO SYTL2 mRNA affects the susceptibility to Mitoxantrone CTD PMID:16044152 NCBI chr 1:153,685,403...153,791,758
Ensembl chr 1:144,273,360...144,379,222 		JBrowse link
G Tagln transgelin affects response to substance ISO TAGLN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Tap1 transporter 1, ATP binding cassette subfamily B member affects response to substance ISO TAP1 protein affects the susceptibility to Mitoxantrone CTD PMID:17523305 NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901 		JBrowse link
G Tbc1d8 TBC1 domain family, member 8 affects response to substance ISO TBC1D8 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409 		JBrowse link
G Tff3 trefoil factor 3 affects response to substance ISO TFF3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP Mitoxantrone results in increased expression of TGFB2 mRNA CTD PMID:23558518 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein affects response to substance ISO TIA1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Mitoxantrone results in increased expression of TIMP1 mRNA CTD PMID:23558518 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tmem47 transmembrane protein 47 affects response to substance ISO TMEM47 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr  X:49,338,532...49,365,026
Ensembl chr  X:45,421,405...45,447,900 		JBrowse link
G Tnks tankyrase affects response to substance ISO TNKS protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr16:57,223,174...57,370,740
Ensembl chr16:57,225,094...57,366,260 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type decreases expression ISO Mitoxantrone results in decreased expression of TNNT1 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 1:78,349,035...78,359,394
Ensembl chr 1:69,306,362...69,316,721 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Mitoxantrone affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpd52 tumor protein D52 affects response to substance ISO TPD52 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
G Tpm1 tropomyosin 1 affects response to substance ISO TPM1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802 		JBrowse link
G Trib1 tribbles pseudokinase 1 affects response to substance ISO TRIB1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:93,096,001...93,102,547
Ensembl chr 7:91,206,579...91,214,731 		JBrowse link
G Trim2 tripartite motif-containing 2 affects response to substance ISO TRIM2 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:169,500,634...169,652,927 		JBrowse link
G Ubl3 ubiquitin-like 3 affects response to substance ISO UBL3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr12:11,509,912...11,554,548
Ensembl chr12:6,473,460...6,518,862 		JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 affects response to substance ISO UCHL1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr14:41,838,859...41,849,743
Ensembl chr14:41,485,031...41,495,590 		JBrowse link
G Uqcrh ubiquinol-cytochrome c reductase hinge protein affects response to substance ISO UQCRH protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 5:134,782,687...134,790,882
Ensembl chr 5:129,545,984...129,554,242 		JBrowse link
G Utrn utrophin affects response to substance ISO UTRN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:6,722,594...7,224,313 		JBrowse link
G Vcan versican affects response to substance ISO VCAN protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:20,761,718...20,860,637 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression ISO Mitoxantrone results in decreased expression of VDAC1 protein CTD PMID:34246718 NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 affects response to substance ISO WARS1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 6:133,540,463...133,571,645
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Washc3 WASH complex subunit 3 affects response to substance ISO WASHC3 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 7:22,621,078...22,665,550
Ensembl chr 7:22,621,078...22,690,696 		JBrowse link
G Xiap X-linked inhibitor of apoptosis affects localization
decreases expression		 ISO Mitoxantrone affects the localization of XIAP protein
Mitoxantrone results in decreased expression of XIAP protein		 CTD PMID:15359644 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression ISO Mitoxantrone results in increased expression of YWHAE protein CTD PMID:32894303 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Zfand1 zinc finger AN1-type containing 1 affects response to substance ISO ZFAND1 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 2:93,351,918...93,364,959
Ensembl chr 2:91,444,508...91,453,246 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Mitoxantrone results in increased expression of ZMAT3 mRNA CTD PMID:26537877 PMID:28940058 NCBI chr 2:117,034,517...117,066,141
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
G Zscan18 zinc finger and SCAN domain containing 18 affects response to substance ISO ZSCAN18 protein affects the susceptibility to Mitoxantrone CTD PMID:16217747 NCBI chr 1:73,332,883...73,349,846
Ensembl chr 1:73,332,889...73,345,897 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        pharmacological role 19113
          analgesic 14789
            mitoxantrone 256
              mitoxantrone dihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbonyl compound 18947
                                    ketone 17281
                                      cyclic ketone 15929
                                        quinone 9916
                                          acenoquinone 7750
                                            anthraquinone 526
                                              hydroxyanthraquinones 514
                                                dihydroxyanthraquinone 354
                                                  mitoxantrone 256
                                                    mitoxantrone dihydrochloride 0
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