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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:milrinone
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Accession:CHEBI:50693 term browser browse the term
Definition:A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Synonyms:related_synonym: 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile;   Formula=C12H9N3O;   InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16);   InChIKey=PZRHRDRVRGEVNW-UHFFFAOYSA-N;   SMILES=Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N;   milrinona;   milrinonum
 alt_id: CHEBI:44019;   CHEBI:6938
 xref: Beilstein:3546821;   CAS:78415-72-2;   DrugBank:DB00235;   Drug_Central:1809;   HMDB:HMDB0014380;   KEGG:C07224;   KEGG:D00417;   LINCS:LSM-3493
 xref_mesh: MESH:D020105
 xref: PDBeChem:MIL;   PMID:10634314;   PMID:14624413;   PMID:14638547;   PMID:21905056;   PMID:21971319;   Patent:BE886336;   Patent:US4313951;   Patent:US4413127;   Reaxys:3546821;   Wikipedia:Milrinone



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milrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide increases expression EXP Milrinone results in increased expression of ADH1 mRNA CTD PMID:22936366 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Akip1 A-kinase interacting protein 1 increases expression EXP Milrinone results in increased expression of AKIP1 mRNA CTD PMID:22936366 NCBI chr 1:163,734,730...163,743,648
Ensembl chr 1:163,734,798...163,743,648
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Milrinone results in decreased expression of ANGPTL4 mRNA CTD PMID:22936366 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Aqp7 aquaporin 7 decreases expression EXP Milrinone results in decreased expression of AQP7 mRNA CTD PMID:22936366 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Milrinone results in decreased expression of ARNTL mRNA CTD PMID:22936366 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Aspn asporin increases expression EXP Milrinone results in increased expression of ASPN mRNA CTD PMID:22936366 NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Milrinone promotes the reaction [CFTR protein affects the secretion of Chlorides]
Milrinone results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 increases expression EXP Milrinone results in increased expression of CHTF8 mRNA CTD PMID:22936366 NCBI chr19:34,782,005...34,792,306
Ensembl chr19:34,781,856...34,792,578
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Milrinone results in increased expression of CREM mRNA CTD PMID:22936366 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crp C-reactive protein decreases expression ISO Milrinone results in decreased expression of CRP protein CTD PMID:11772795 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Milrinone results in increased expression of CSRP2 mRNA CTD PMID:22936366 NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression EXP Milrinone results in increased expression of CTHRC1 mRNA CTD PMID:22936366 NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP Milrinone results in increased expression of DBP mRNA CTD PMID:22936366 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression EXP Milrinone results in decreased expression of EIF4EBP2 mRNA CTD PMID:22936366 NCBI chr20:29,379,444...29,400,131
Ensembl chr20:29,382,668...29,399,946
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 decreases expression EXP Milrinone results in decreased expression of FAM171A1 mRNA CTD PMID:22936366 NCBI chr17:75,024,582...75,148,348
Ensembl chr17:75,024,575...75,150,255
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Milrinone results in increased expression of FHL1 mRNA CTD PMID:22936366 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Milrinone results in increased expression of GADD45G mRNA CTD PMID:22936366 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Milrinone results in increased expression of GPNMB mRNA CTD PMID:22936366 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression EXP Milrinone results in increased expression of HADH mRNA CTD PMID:22936366 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Milrinone results in decreased expression of IGKC mRNA CTD PMID:22936366
G Il6 interleukin 6 multiple interactions ISO Milrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lyz2 lysozyme 2 increases expression EXP Milrinone results in increased expression of LYZ2 mRNA CTD PMID:22936366 NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
JBrowse link
G Msi2 musashi RNA-binding protein 2 increases expression EXP Milrinone results in increased expression of MSI2 mRNA CTD PMID:22936366 NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Milrinone results in increased expression of MYH7 mRNA CTD PMID:22936366 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Milrinone results in increased expression of MYL1 mRNA CTD PMID:22936366 NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
JBrowse link
G Noct nocturnin increases expression EXP Milrinone results in increased expression of NOCT mRNA CTD PMID:22936366 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Milrinone results in increased expression of NPPA mRNA CTD PMID:22936366 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Milrinone results in increased expression of NR4A3 mRNA CTD PMID:22936366 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Per2 period circadian regulator 2 increases expression EXP Milrinone results in increased expression of PER2 mRNA CTD PMID:22936366 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Postn periostin increases expression EXP Milrinone results in increased expression of POSTN mRNA CTD PMID:22936366 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Milrinone results in increased expression of REG3B mRNA CTD PMID:22936366 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
JBrowse link
G Ren renin multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Milrinone results in increased expression of S100A4 mRNA CTD PMID:22936366 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Milrinone results in increased expression of SPP1 mRNA CTD PMID:22936366 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Thbs4 thrombospondin 4 increases expression EXP Milrinone results in increased expression of THBS4 mRNA CTD PMID:22936366 NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Milrinone results in increased expression of TIMP1 mRNA CTD PMID:22936366 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Milrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8937731 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      group 19986
        pseudohalo group 3902
          cyano group 3902
            nitrile 3902
              milrinone 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteromonocyclic compound 17145
                                    pyridines 9181
                                      pyridone 140
                                        milrinone 38
paths to the root