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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:milrinone
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Accession:CHEBI:50693 term browser browse the term
Definition:A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Synonyms:related_synonym: 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile;   Formula=C12H9N3O;   InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16);   InChIKey=PZRHRDRVRGEVNW-UHFFFAOYSA-N;   SMILES=Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N;   milrinona;   milrinonum
 alt_id: CHEBI:44019;   CHEBI:6938
 xref: Beilstein:3546821;   CAS:78415-72-2;   DrugBank:DB00235;   Drug_Central:1809;   HMDB:HMDB0014380;   KEGG:C07224;   KEGG:D00417;   LINCS:LSM-3493
 xref_mesh: MESH:D020105
 xref: PDBeChem:MIL;   PMID:10634314;   PMID:14624413;   PMID:14638547;   PMID:21905056;   PMID:21971319;   Patent:BE886336;   Patent:US4313951;   Patent:US4413127;   Reaxys:3546821;   Wikipedia:Milrinone


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milrinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) increases expression EXP Milrinone results in increased expression of ADH1 mRNA CTD PMID:22936366 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Akip1 A-kinase interacting protein 1 increases expression EXP Milrinone results in increased expression of AKIP1 mRNA CTD PMID:22936366 NCBI chr 1:174,330,628...174,339,494
Ensembl chr 1:174,330,695...174,339,494
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression EXP Milrinone results in decreased expression of ANGPTL4 mRNA CTD PMID:22936366 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Aqp7 aquaporin 7 decreases expression EXP Milrinone results in decreased expression of AQP7 mRNA CTD PMID:22936366 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Milrinone results in decreased expression of ARNTL mRNA CTD PMID:22936366 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Aspn asporin increases expression EXP Milrinone results in increased expression of ASPN mRNA CTD PMID:22936366 NCBI chr17:14,655,958...14,681,355
Ensembl chr17:14,656,009...14,679,409
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO Milrinone promotes the reaction [CFTR protein affects the secretion of Chlorides]
Milrinone results in increased activity of CFTR protein
CTD PMID:12714375 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 increases expression EXP Milrinone results in increased expression of CHTF8 mRNA CTD PMID:22936366 NCBI chr19:39,077,580...39,087,880
Ensembl chr19:39,077,580...39,087,880
JBrowse link
G Crem cAMP responsive element modulator increases expression EXP Milrinone results in increased expression of CREM mRNA CTD PMID:22936366 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crp C-reactive protein decreases expression ISO Milrinone results in decreased expression of CRP protein CTD PMID:11772795 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 increases expression EXP Milrinone results in increased expression of CSRP2 mRNA CTD PMID:22936366 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310
JBrowse link
G Cthrc1 collagen triple helix repeat containing 1 increases expression EXP Milrinone results in increased expression of CTHRC1 mRNA CTD PMID:22936366 NCBI chr 7:77,966,722...77,977,004
Ensembl chr 7:77,966,722...77,977,004
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP Milrinone results in increased expression of DBP mRNA CTD PMID:22936366 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression EXP Milrinone results in decreased expression of EIF4EBP2 mRNA CTD PMID:22936366 NCBI chr20:31,055,292...31,072,469
Ensembl chr20:31,055,789...31,072,469
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 decreases expression EXP Milrinone results in decreased expression of FAM171A1 mRNA CTD PMID:22936366 NCBI chr17:79,030,150...79,149,480
Ensembl chr17:79,031,423...79,085,076
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression EXP Milrinone results in increased expression of FHL1 mRNA CTD PMID:22936366 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression EXP Milrinone results in increased expression of GADD45G mRNA CTD PMID:22936366 NCBI chr17:13,391,474...13,393,219
Ensembl chr17:13,391,467...13,393,243
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Milrinone results in increased expression of GPNMB mRNA CTD PMID:22936366 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression EXP Milrinone results in increased expression of HADH mRNA CTD PMID:22936366 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Igkc immunoglobulin kappa constant decreases expression EXP Milrinone results in decreased expression of IGKC mRNA CTD PMID:22936366
G Il6 interleukin 6 multiple interactions ISO Milrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:21088047 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lyz2 lysozyme 2 increases expression EXP Milrinone results in increased expression of LYZ2 mRNA CTD PMID:22936366 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Msi2 musashi RNA-binding protein 2 increases expression EXP Milrinone results in increased expression of MSI2 mRNA CTD PMID:22936366 NCBI chr10:75,673,840...76,040,106
Ensembl chr10:75,681,393...76,039,964
JBrowse link
G Myh7 myosin heavy chain 7 increases expression EXP Milrinone results in increased expression of MYH7 mRNA CTD PMID:22936366 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myl1 myosin, light chain 1 increases expression EXP Milrinone results in increased expression of MYL1 mRNA CTD PMID:22936366 NCBI chr 9:73,937,820...73,958,480
Ensembl chr 9:73,937,823...73,958,480
JBrowse link
G Noct nocturnin increases expression EXP Milrinone results in increased expression of NOCT mRNA CTD PMID:22936366 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Milrinone results in increased expression of NPPA mRNA CTD PMID:22936366 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 increases expression EXP Milrinone results in increased expression of NR4A3 mRNA CTD PMID:22936366 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Per2 period circadian regulator 2 increases expression EXP Milrinone results in increased expression of PER2 mRNA CTD PMID:22936366 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Postn periostin increases expression EXP Milrinone results in increased expression of POSTN mRNA CTD PMID:22936366 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Milrinone results in increased expression of REG3B mRNA CTD PMID:22936366 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Ren renin multiple interactions ISO Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein] CTD PMID:20651700 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Milrinone results in increased expression of S100A4 mRNA CTD PMID:22936366 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Milrinone results in increased expression of SPP1 mRNA CTD PMID:22936366 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Thbs4 thrombospondin 4 increases expression EXP Milrinone results in increased expression of THBS4 mRNA CTD PMID:22936366 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Milrinone results in increased expression of TIMP1 mRNA CTD PMID:22936366 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Milrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:8937731 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    chemical entity 19817
      group 19728
        pseudohalo group 2914
          cyano group 2914
            nitrile 2914
              milrinone 38
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic molecule 19532
                              organic cyclic compound 19348
                                organic heterocyclic compound 18475
                                  organic heteromonocyclic compound 16598
                                    pyridines 8426
                                      pyridone 121
                                        milrinone 38
paths to the root