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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cross-linking reagent
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Accession:CHEBI:50684 term browser browse the term
Definition:A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified.
Synonyms:related_synonym: cross-linking reagents

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  CHEBI ontology 19816
    role 19764
      application 19426
        reagent 17187
          cross-linking reagent 7371
            1,3-dichloropropan-2-ol + 34
            1,3-dicyclohexylcarbodiimide 2
            Genipin 74
            N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide 0
            cisplatin 7336
            cyanuric chloride 3
            divinyl sulfone 3
            ethylene glycol dimethacrylate 12
            glutaraldehyde 12
            methoxsalen + 57
            pentosidine 0
            tetrachlorophthalic anhydride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.