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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 1.5.1.3 (dihydrofolate reductase) inhibitor
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Accession:CHEBI:50683 term browser browse the term
Definition:An EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of dihydrofolate reductase (EC 1.5.1.3).
Synonyms:related_synonym: 7,8-dihydrofolate reductase inhibitor;   7,8-dihydrofolate reductase inhibitors;   DHFR inhibitor;   DHFR inhibitors;   EC 1.5.1.3 inhibitor;   EC 1.5.1.3 inhibitors;   NADPH-dihydrofolate reductase inhibitor;   NADPH-dihydrofolate reductase inhibitors;   dihydrofolate reductase (EC 1.5.1.3) inhibitors;   dihydrofolate reductase inhibitor;   dihydrofolate reductase inhibitors;   dihydrofolic acid reductase inhibitor;   dihydrofolic acid reductase inhibitors;   dihydrofolic reductase inhibitor;   dihydrofolic reductase inhibitors;   folic acid reductase inhibitor;   folic acid reductase inhibitors;   folic reductase inhibitor;   folic reductase inhibitors;   tetrahydrofolate dehydrogenase inhibitor;   tetrahydrofolate dehydrogenase inhibitors
 xref: Wikipedia:Dihydrofolate_reductase_inhibitor


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          antimetabolite 8495
            antifolate 4007
              EC 1.5.1.3 (dihydrofolate reductase) inhibitor 4007
                (R)-iclaprim + 0
                (S)-iclaprim + 0
                4-aminofolic acid 0
                O-(chloroacetylcarbamoyl)fumagillol 10
                brodimoprim 0
                cycloguanil + 0
                iclaprim 0
                methotrexate 2368
                methotrexate disodium 0
                pemetrexed 36
                pemetrexed disodium + 0
                pemetrexed disodium heptahydrate 0
                pralatrexate 0
                proguanil 4
                pyrimethamine 20
                triclosan 2035
                trimethoprim + 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        inhibitor 18241
          enzyme inhibitor 18166
            EC 1.* (oxidoreductase) inhibitor 16527
              EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor 4007
                EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor 4007
                  EC 1.5.1.3 (dihydrofolate reductase) inhibitor 4007
                    (R)-iclaprim + 0
                    (S)-iclaprim + 0
                    4-aminofolic acid 0
                    O-(chloroacetylcarbamoyl)fumagillol 10
                    brodimoprim 0
                    cycloguanil + 0
                    iclaprim 0
                    methotrexate 2368
                    methotrexate disodium 0
                    pemetrexed 36
                    pemetrexed disodium + 0
                    pemetrexed disodium heptahydrate 0
                    pralatrexate 0
                    proguanil 4
                    pyrimethamine 20
                    triclosan 2035
                    trimethoprim + 11
paths to the root

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