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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dronedarone
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Accession:CHEBI:50659 term browser browse the term
Definition:A member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias.
Synonyms:exact_synonym: N-[2-butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide
 related_synonym: Formula=C31H44N2O5S;   InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3;   InChIKey=ZQTNQVWKHCQYLQ-UHFFFAOYSA-N;   Multaq;   N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide;   N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide;   SMILES=CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c1c(CCCC)oc2ccc(NS(C)(=O)=O)cc12;   SR 33589;   SR 33589B
 xref: CAS:141626-36-0;   Drug_Central:4112;   KEGG:D02537
 xref_mesh: MESH:C118667
 xref: PMID:23338943;   PMID:24084222;   PMID:24486334;   Patent:EP2684564;   Patent:MX2013006564;   Reaxys:8176529;   Wikipedia:Dronedarone


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dronedarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO dronedarone results in increased activity of CASP3 protein CTD PMID:23135547 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO dronedarone results in increased activity of CASP7 protein CTD PMID:23135547 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dronedarone results in decreased expression of CCND1 protein CTD PMID:29616291 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO dronedarone results in decreased expression of CCND3 protein CTD PMID:29616291 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO dronedarone results in decreased expression of CDK2 protein CTD PMID:29616291 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO dronedarone results in decreased expression of CDK4 protein CTD PMID:29616291 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO dronedarone results in decreased expression of CDK6 protein CTD PMID:29616291 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases activity ISO dronedarone results in decreased activity of CPT1A protein CTD PMID:24881592 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
multiple interactions
ISO CYP1A1 protein results in increased susceptibility to dronedarone
CYP1A1 protein results in increased metabolism of dronedarone
[CYP1A1 protein results in increased metabolism of dronedarone] which results in increased abundance of N-desbutyldronedarone
CTD PMID:29616291 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of dronedarone CTD PMID:29616291 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases metabolic processing ISO CYP2C18 protein results in increased metabolism of dronedarone CTD PMID:29616291 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of dronedarone CTD PMID:29616291 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases response to substance
increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in decreased susceptibility to dronedarone
CYP2D6 protein results in increased metabolism of dronedarone
[CYP2D6 protein results in increased metabolism of Dronedarone] which results in decreased abundance of N-desbutyldronedarone; CYP2D6 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP2D6 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]
CTD PMID:29616291 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of dronedarone CTD PMID:29616291 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases response to substance
increases metabolic processing
multiple interactions
ISO CYP3A4 protein results in decreased susceptibility to Dronedarone
CYP3A4 protein results in increased metabolism of Dronedarone
[CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased abundance of N-desbutyldronedarone; [CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased chemical synthesis of N-desbutyldronedarone; CYP3A4 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]
CTD PMID:29616291 PMID:31756459 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases metabolic processing
decreases response to substance
ISO [CYP3A5 protein results in increased metabolism of Dronedarone] which results in increased abundance of N-desbutyldronedarone; CYP3A5 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A5 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]
CYP3A5 protein results in increased metabolism of dronedarone
CYP3A5 protein results in decreased susceptibility to dronedarone
CTD PMID:29616291 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dronedarone binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO dronedarone binds to and results in decreased activity of ESR2 protein CTD PMID:25752796 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO CYP2D6 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]; CYP3A5 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]; TOP2A protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein] CTD PMID:29616291 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO dronedarone results in decreased activity of KCNH2 protein
Potassium inhibits the reaction [dronedarone results in decreased activity of KCNH2 protein]
CTD PMID:15618689 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression EXP dronedarone results in decreased expression of MYH6 mRNA CTD PMID:17535870 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Pgr progesterone receptor multiple interactions ISO dronedarone binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Slc22a5 solute carrier family 22 member 5 affects response to substance ISO SLC22A5 protein affects the susceptibility to dronedarone CTD PMID:24881592 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO dronedarone results in increased expression of SOD2 mRNA CTD PMID:23135547 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
decreases expression
ISO
EXP
dronedarone binds to and results in decreased activity of THRA protein
dronedarone results in decreased expression of THRA mRNA alternative form
CTD PMID:17535870 PMID:25752796 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP dronedarone results in decreased expression of THRB mRNA alternative form CTD PMID:17535870 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
multiple interactions
ISO dronedarone results in decreased expression of TOP2A mRNA; dronedarone results in decreased expression of TOP2A protein
CYP2D6 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A5 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; TOP2A protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]
CTD PMID:29616291 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link

Term paths to the root
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  CHEBI ontology 19821
    role 19769
      biological role 19769
        xenobiotic 18452
          dronedarone 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                chalcogen oxoacid 11491
                                  sulfur oxoacid 11099
                                    sulfonic acid 7363
                                      sulfonic acid derivative 7363
                                        sulfonamide 3191
                                          dronedarone 27
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