The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
CYP1A1 protein results in increased susceptibility to dronedarone [CYP1A1 protein results in increased metabolism of dronedarone] which results in increased abundance of N-desbutyldronedarone Dronedarone results in decreased activity of CYP1A1 protein
CYP2D6 protein results in decreased susceptibility to dronedarone [CYP2D6 protein results in increased metabolism of Dronedarone] which results in decreased abundance of N-desbutyldronedarone; CYP2D6 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP2D6 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein] CYP2D6 protein results in increased metabolism of dronedarone
CYP3A4 protein results in decreased susceptibility to Dronedarone [CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased abundance of N-desbutyldronedarone; [CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased chemical synthesis of N-desbutyldronedarone; CYP3A4 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]
[CYP3A5 protein results in increased metabolism of Dronedarone] which results in increased abundance of N-desbutyldronedarone; CYP3A5 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A5 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein] CYP3A5 protein results in decreased susceptibility to dronedarone CYP3A5 protein results in increased metabolism of dronedarone
CYP2D6 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]; CYP3A5 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]; TOP2A protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]
dronedarone results in decreased activity of KCNH2 protein Potassium inhibits the reaction [dronedarone results in decreased activity of KCNH2 protein]
dronedarone results in decreased expression of TOP2A mRNA; dronedarone results in decreased expression of TOP2A protein CYP2D6 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A4 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; CYP3A5 protein inhibits the reaction [Dronedarone results in decreased expression of TOP2A protein]; TOP2A protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein]