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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-cis-retinoic acid
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Accession:CHEBI:50648 term browser browse the term
Definition:A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Synonyms:exact_synonym: (9cis)-retinoic acid
 related_synonym: (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid;   (7E,9Z,11E,13E)-retinoic acid;   9(Z)-Retinoic acid;   9-cis-Tretinoin;   Alitretinoin;   Formula=C20H28O2;   InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+;   InChIKey=SHGAZHPCJJPHSC-ZVCIMWCZSA-N;   Panretin;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C\\C=C\\C(C)=C\\C(O)=O;   alitretinoina;   alitretinoine;   alitretinoinum
 alt_id: CHEBI:63793
 xref: CAS:5300-03-8;   DrugBank:DB00523;   Drug_Central:3862;   HMDB:HMDB0002369;   KEGG:C15493;   KEGG:D02815;   LIPID_MAPS_instance:LMPR01090022
 xref_mesh: MESH:C103303
 xref: PMID:10684759;   PMID:11978340;   PMID:12611604;   PMID:12882648;   PMID:15217968;   PMID:15292987;   PMID:15519497;   PMID:16144296;   PMID:17019405;   PMID:18400206;   PMID:18404486;   PMID:19678713;   PMID:7670094;   Reaxys:2057222;   Wikipedia:Alitretinoin
 cyclic_relationship: is_conjugate_acid_of CHEBI:78630


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9-cis-retinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO
EXP
3-aminobenzamide promotes the reaction [Alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]]; 3-aminobenzamide promotes the reaction [Alitretinoin results in increased expression of ABCA1 mRNA]; Alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]; Alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 protein]; TO-901317 promotes the reaction [Alitretinoin results in increased expression of ABCA1 mRNA]
[22-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 mRNA; [22-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein
[22-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein; [25-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein; [Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA; [Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein; Arsenic Trioxide inhibits the reaction [[Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA]; Arsenic Trioxide inhibits the reaction [[Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein]
CTD PMID:16023994, PMID:16184197, PMID:17478430, PMID:27026705 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Alitretinoin results in increased expression of ABCC3 mRNA CTD PMID:15824121 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases expression
ISO RARA protein promotes the reaction [Alitretinoin results in increased expression of ABCC6 mRNA] CTD PMID:17045963 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression EXP Alitretinoin results in increased expression of ABCD3 mRNA CTD PMID:16648578 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
ISO [TO-901317 co-treated with Alitretinoin] results in increased expression of ABCG1 mRNA
Alitretinoin results in increased expression of ABCG1 mRNA
CTD PMID:16024918, PMID:16730733 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Alitretinoin results in increased expression of ACOT2 mRNA CTD PMID:16648578 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
EXP Alitretinoin results in increased expression of ACTA2 mRNA
15-deoxyprostaglandin J2 inhibits the reaction [Alitretinoin results in increased expression of ACTA2 mRNA]; Alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of ACTA2 mRNA]
CTD PMID:17161435 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Alitretinoin results in decreased expression of ACTG2 protein CTD PMID:16043492 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723
JBrowse link
G Adipor1 adiponectin receptor 1 multiple interactions ISO [25-hydroxycholesterol co-treated with Alitretinoin] results in decreased expression of ADIPOR1 mRNA CTD PMID:16023994 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression EXP Alitretinoin results in decreased expression of AHSG mRNA CTD PMID:16648578 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO Alitretinoin results in decreased expression of AIP mRNA CTD PMID:15982314 NCBI chr 1:219,361,859...219,373,924
Ensembl chr 1:219,361,860...219,374,014
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO
EXP
Alitretinoin results in decreased phosphorylation of AKT1 protein
Alitretinoin results in increased phosphorylation of AKT1 protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of AKT1 protein
CTD PMID:16288212, PMID:16340750, PMID:16611854, PMID:18063688 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Alitretinoin results in decreased expression of ANXA1 protein CTD PMID:28886987 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 decreases expression ISO Alitretinoin results in decreased expression of ANXA2 protein CTD PMID:28886987 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Alitretinoin results in decreased expression of ANXA5 protein CTD PMID:28886987 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Apoa2 apolipoprotein A2 increases expression
multiple interactions
ISO Alitretinoin results in increased expression of APOA2 mRNA
RXRA promotes the reaction [Alitretinoin results in increased expression of APOA2 mRNA]
CTD PMID:8668150 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B increases expression EXP Alitretinoin results in increased expression of ARPC1B mRNA CTD PMID:16648578 NCBI chr12:11,252,300...11,265,849
Ensembl chr12:11,252,296...11,265,865
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Alitretinoin results in decreased expression of ATP1B1 mRNA CTD PMID:16648578 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Alitretinoin results in increased expression of BAX; Alitretinoin results in increased expression of BAX protein
seocalcitol inhibits the reaction [Alitretinoin results in increased expression of BAX protein]
CTD PMID:12189556, PMID:16109544, PMID:16340750, PMID:16909596 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
decreases response to substance
ISO Alitretinoin results in decreased expression of BCL2; Alitretinoin results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Alitretinoin
CTD PMID:12189556, PMID:16109544, PMID:16909596, PMID:17077328 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO seocalcitol inhibits the reaction [Alitretinoin results in increased expression of BCL2L11 protein] CTD PMID:16340750 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bco1 beta-carotene oxygenase 1 decreases expression EXP Alitretinoin results in decreased expression of BCO1 mRNA CTD PMID:16699835 NCBI chr19:49,637,059...49,673,577
Ensembl chr19:49,637,016...49,673,808
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
decreases expression
ISO [Calcitriol co-treated with Alitretinoin] results in increased expression of BGLAP mRNA; [Calcitriol co-treated with Alitretinoin] results in increased secretion of BGLAP protein; [KH 1060 co-treated with Alitretinoin] results in increased expression of BGLAP mRNA; [KH 1060 co-treated with Alitretinoin] results in increased secretion of BGLAP protein; Alitretinoin promotes the reaction [Calcitriol results in increased expression of BGLAP mRNA]; Alitretinoin promotes the reaction [Calcitriol results in increased secretion of BGLAP protein]; Alitretinoin promotes the reaction [KH 1060 results in increased expression of BGLAP mRNA]; Alitretinoin promotes the reaction [KH 1060 results in increased secretion of BGLAP protein]; Alitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]; Alitretinoin promotes the reaction [VDR protein binds to BGLAP gene]
Alitretinoin results in decreased expression of BGLAP mRNA
CTD PMID:12898515, PMID:16392701 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma increases expression EXP Alitretinoin results in increased expression of CAMK2G mRNA CTD PMID:16648578 NCBI chr15:3,936,721...3,995,740
Ensembl chr15:3,936,786...3,995,915
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP CAMK4 protein promotes the reaction [Alitretinoin results in increased activity of RARA protein] CTD PMID:15773917 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
JBrowse link
G Capn1 calpain 1 decreases expression ISO Alitretinoin results in decreased expression of CAPN1 mRNA CTD PMID:17460283 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 decreases expression ISO Alitretinoin results in decreased expression of CAPN2 mRNA CTD PMID:17460283 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
increases expression
ISO [Alitretinoin co-treated with seocalcitol] results in increased expression of CA2 protein
Alitretinoin results in increased expression of CA2 protein
CTD PMID:16340750 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO
EXP
Alitretinoin results in increased expression of CASP3; Alitretinoin results in increased expression of CASP3 protein
[TO-901317 co-treated with Alitretinoin] promotes the reaction [Palmitic Acid results in increased activity of CASP3 protein]
CTD PMID:16109544, PMID:16909596, PMID:17194744 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions EXP [TO-901317 co-treated with Alitretinoin] promotes the reaction [Palmitic Acid results in increased activity of CASP7 protein] CTD PMID:17194744 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO Alitretinoin results in increased activity of CASP8 protein CTD PMID:16449964 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cbx3 chromobox 3 decreases expression ISO Alitretinoin results in decreased expression of CBX3 mRNA CTD PMID:15982314 NCBI chr 4:81,243,809...81,257,898
Ensembl chr 4:81,244,469...81,257,897
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]] CTD PMID:21268089 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein] CTD PMID:11348869 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Alitretinoin results in decreased expression of CCND3 protein CTD PMID:16273314 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of CCR2 mRNA; Alitretinoin results in decreased expression of CCR2 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Alitretinoin results in decreased expression of CCR2 mRNA]
CTD PMID:16712875
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO Alitretinoin results in increased expression of CCR3 mRNA CTD PMID:16712875 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression
decreases expression
ISO Alitretinoin results in increased expression of CCR7 protein
Alitretinoin results in decreased expression of CCR7 protein
CTD PMID:17475839 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Cd36 CD36 molecule decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of CD36 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in decreased expression of CD36 protein]; [Alitretinoin co-treated with Rosiglitazone] results in increased expression of CD36 protein; HX 630 inhibits the reaction [Alitretinoin results in decreased expression of CD36 protein]
CTD PMID:17475839 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cd37 CD37 molecule increases expression EXP Alitretinoin results in increased expression of CD37 mRNA CTD PMID:16648578 NCBI chr 1:101,230,470...101,236,061
Ensembl chr 1:101,230,533...101,236,065
JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions
ISO Alitretinoin results in increased expression of CD38 mRNA
Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CD38 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CD38 mRNA]]
CTD PMID:15964820, PMID:21393419 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd80 Cd80 molecule decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of CD80 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in decreased expression of CD80 protein]; [Alitretinoin co-treated with Rosiglitazone] results in decreased expression of CD80 protein; HX 630 inhibits the reaction [Alitretinoin results in decreased expression of CD80 protein]
CTD PMID:17475839 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule increases expression ISO Alitretinoin results in increased expression of CD83 protein CTD PMID:17475839 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions
ISO Alitretinoin results in increased expression of CD86 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in increased expression of CD86 protein]; [Alitretinoin co-treated with Rosiglitazone] results in increased expression of CD86 protein; HX 630 inhibits the reaction [Alitretinoin results in increased expression of CD86 protein]
CTD PMID:17475839 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdh1 cadherin 1 affects expression ISO Alitretinoin affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Alitretinoin results in decreased expression of CDKN1A protein CTD PMID:16340750 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases stability
multiple interactions
increases expression
ISO Alitretinoin results in increased stability of CDKN1B protein
Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]; seocalcitol inhibits the reaction [Alitretinoin results in increased expression of CDKN1B protein]
CTD PMID:11348869, PMID:16340750 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Alitretinoin results in decreased expression of CDKN1C mRNA CTD PMID:15982314 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased activity of CEBPB protein CTD PMID:15150131 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Alitretinoin results in decreased expression of CIAO1 mRNA CTD PMID:16648578 NCBI chr 3:119,671,778...119,677,324
Ensembl chr 3:119,671,779...119,678,092
JBrowse link
G Ciita class II, major histocompatibility complex, transactivator increases expression ISO Alitretinoin results in increased expression of CIITA mRNA CTD PMID:17229644 NCBI chr10:5,212,621...5,260,641
Ensembl chr10:5,213,350...5,260,608
JBrowse link
G Cnn1 calponin 1 multiple interactions
increases expression
EXP 15-deoxyprostaglandin J2 inhibits the reaction [Alitretinoin results in increased expression of CNN1 mRNA]; Alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA] CTD PMID:17161435 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression EXP Alitretinoin results in decreased expression of COL12A1 mRNA CTD PMID:16648578 NCBI chr 8:87,042,820...87,150,701
Ensembl chr 8:87,040,799...87,158,368
JBrowse link
G Col17a1 collagen type XVII alpha 1 chain decreases expression ISO Alitretinoin results in decreased expression of COL17A1 mRNA CTD PMID:15982314 NCBI chr 1:267,416,681...267,465,049
Ensembl chr 1:267,417,459...267,463,705
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Alitretinoin results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression EXP Alitretinoin results in increased expression of COL1A2 mRNA CTD PMID:16648578 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO Alitretinoin results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:83,386,388...83,522,169
Ensembl chr16:83,387,364...83,438,561
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO Alitretinoin results in decreased expression of COL6A1 mRNA CTD PMID:15982314 NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
JBrowse link
G Col8a2 collagen type VIII alpha 2 chain increases expression ISO Alitretinoin results in increased expression of COL8A2 mRNA CTD PMID:15982314 NCBI chr 5:144,308,527...144,335,142
Ensembl chr 5:144,308,611...144,335,172
JBrowse link
G Coro1b coronin 1B increases expression EXP Alitretinoin results in increased expression of CORO1B mRNA CTD PMID:16648578 NCBI chr 1:219,397,827...219,403,253
Ensembl chr 1:219,397,850...219,403,260
JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 decreases response to substance ISO CRABP1 protein results in decreased susceptibility to Alitretinoin CTD PMID:16254461 NCBI chr 8:59,344,097...59,352,135
Ensembl chr 8:59,344,083...59,352,132
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO
EXP
Alitretinoin results in increased expression of CRABP2 mRNA
Alitretinoin analog results in increased expression of CRABP2 mRNA; Alitretinoin results in increased expression of CRABP2 mRNA
CTD PMID:11214822, PMID:16339527, PMID:16946489, PMID:17034753 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation ISO Alitretinoin results in increased phosphorylation of CREB1 protein CTD PMID:16280361 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression EXP Alitretinoin results in increased expression of CROT mRNA CTD PMID:16648578 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Alitretinoin results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression EXP Alitretinoin results in decreased expression of CXCL14 mRNA CTD PMID:16648578 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Alitretinoin results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
EXP
ISO
Alitretinoin promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CYP19A1 mRNA]
Alitretinoin results in decreased expression of CYP19A1 mRNA
Alitretinoin results in increased expression of CYP19A1 mRNA
[Alitretinoin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA]
CTD PMID:12706301, PMID:15941851, PMID:16357189 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Alitretinoin results in increased expression of CYP26A1 mRNA CTD PMID:16194896, PMID:16688765 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 multiple interactions
increases expression
increases metabolic processing
ISO Alitretinoin inhibits the reaction [CYP26C1 protein binds to and results in increased metabolism of Tretinoin]; CYP26C1 protein binds to and results in increased metabolism of Alitretinoin; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Alitretinoin]
Alitretinoin results in increased expression of CYP26C1 mRNA
CYP26C1 results in increased metabolism of Alitretinoin
CTD PMID:14532297, PMID:21906690 NCBI chr 1:256,369,410...256,380,649
Ensembl chr 1:256,370,850...256,378,335
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
ISO Alitretinoin results in increased expression of CYP27A1 mRNA
Alitretinoin results in decreased expression of CYP27A1 mRNA
Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CYP27A1 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CYP27A1 mRNA]]
CTD PMID:15964820, PMID:15982314 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO RXRA protein affects the reaction [Alitretinoin results in increased expression of CYP2B6 mRNA] CTD PMID:31312845 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO Alitretinoin results in increased expression of DHRS9 mRNA CTD PMID:11304534 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity ISO Alitretinoin results in increased activity of DIO3 protein CTD PMID:16935842 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression EXP Alitretinoin results in decreased expression of DNAJA1 mRNA CTD PMID:16648578 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dsc1 desmocollin 1 decreases expression ISO Alitretinoin results in decreased expression of DSC1 mRNA CTD PMID:15982314 NCBI chr18:11,877,918...11,906,828
Ensembl chr18:11,877,561...11,906,827
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Alitretinoin results in increased expression of DUSP10 mRNA CTD PMID:15982314 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Alitretinoin results in decreased expression of DUSP11 mRNA CTD PMID:15982314 NCBI chr 4:117,617,640...117,631,674
Ensembl chr 4:117,617,533...117,631,716
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Alitretinoin results in decreased expression of EGFR mRNA CTD PMID:15982314 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression ISO Alitretinoin results in decreased expression of EIF4EBP2 mRNA CTD PMID:15982314 NCBI chr20:31,055,292...31,072,469
Ensembl chr20:31,055,789...31,072,469
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Alitretinoin results in increased expression of EMP1 mRNA CTD PMID:15982314 NCBI chr 4:169,161,076...169,181,967
Ensembl chr 4:169,147,243...169,181,966
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO
EXP
Alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA]
Melatonin promotes the reaction [Alitretinoin results in decreased expression of ESR1 mRNA]
CTD PMID:16051031, PMID:19340624 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR2 mRNA] CTD PMID:19340624 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Alitretinoin results in decreased expression of FABP5 mRNA CTD PMID:15982314 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C increases expression ISO Alitretinoin results in increased expression of FAM3C mRNA CTD PMID:15982314 NCBI chr 4:49,388,962...49,439,892
Ensembl chr 4:49,387,989...49,439,867
JBrowse link
G Fas Fas cell surface death receptor decreases expression
increases expression
ISO Alitretinoin results in decreased expression of FAS mRNA
Alitretinoin results in increased expression of FAS mRNA
CTD PMID:16712844, PMID:17034753 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Alitretinoin results in decreased expression of FASN mRNA CTD PMID:15982314 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO Alitretinoin results in decreased expression of FASTK mRNA CTD PMID:15982314 NCBI chr 4:7,260,521...7,264,590
Ensembl chr 4:7,260,575...7,264,589
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Alitretinoin results in increased expression of FDFT1 mRNA CTD PMID:16648578 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Alitretinoin results in decreased expression of FGF1 mRNA CTD PMID:15982314 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression
multiple interactions
EXP Alitretinoin results in increased expression of FHL1 mRNA
15-deoxyprostaglandin J2 inhibits the reaction [Alitretinoin results in increased expression of FHL1 mRNA]; Alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]
CTD PMID:17161435 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Flg filaggrin decreases expression ISO Alitretinoin results in decreased expression of FLG mRNA CTD PMID:15982314 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Fn1 fibronectin 1 increases expression
decreases expression
EXP
ISO
Alitretinoin results in increased expression of FN1 mRNA
Alitretinoin results in decreased expression of FN1 mRNA; Alitretinoin results in decreased expression of FN1 protein
CTD PMID:11139446, PMID:16648578 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO Alitretinoin results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:78,516,579...78,549,669
Ensembl chr 6:78,545,804...78,549,669
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Alitretinoin results in increased expression of G6PD mRNA CTD PMID:15982314 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO Alitretinoin results in decreased expression of GAPDH protein CTD PMID:28886987 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Alitretinoin results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,415,821...2,447,087
Ensembl chr18:2,416,552...2,446,338
JBrowse link
G Gba glucosylceramidase beta decreases expression ISO Alitretinoin results in decreased expression of GBA mRNA CTD PMID:15982314 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601
JBrowse link
G Gck glucokinase decreases expression
decreases activity
ISO
EXP
Alitretinoin results in decreased expression of GCK mRNA
Alitretinoin results in decreased activity of GCK protein
CTD PMID:21115832, PMID:21670153 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Alitretinoin results in increased expression of GDF15 mRNA CTD PMID:15982314 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdf2 growth differentiation factor 2 decreases expression ISO Alitretinoin results in decreased expression of GDF2 mRNA CTD PMID:15982314 NCBI chr16:10,267,510...10,293,545
Ensembl chr16:10,267,482...10,273,239
JBrowse link
G Gh1 growth hormone 1 increases expression
multiple interactions
EXP Alitretinoin results in increased expression of GH1 mRNA
Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]]
CTD PMID:10720163, PMID:15240998, PMID:17090972 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Ghrh growth hormone releasing hormone multiple interactions EXP Alitretinoin promotes the reaction [Dexamethasone results in increased expression of GHRH mRNA] CTD PMID:17090972 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Alitretinoin results in increased expression of GLUL mRNA CTD PMID:15982314 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Alitretinoin results in increased expression of GPX2 mRNA CTD PMID:15623509 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases expression ISO Alitretinoin results in decreased expression of GRB7 mRNA CTD PMID:15982314 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression
EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]; [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased expression of GSTA2 mRNA; [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased expression of GSTA2 protein; [Pioglitazone co-treated with Alitretinoin] results in increased expression of GSTA2 protein; [Rosiglitazone co-treated with Alitretinoin] results in increased expression of GSTA2 protein; [Troglitazone co-treated with Alitretinoin] results in increased expression of GSTA2 protein
Alitretinoin results in increased expression of GSTA2 protein
CTD PMID:15150131 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Alitretinoin results in decreased expression of GSTM1 mRNA CTD PMID:15982314 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G H3f4 H3.4 histone multiple interactions ISO [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H3-4 protein] CTD PMID:15964820 NCBI chr10:45,304,696...45,305,106 JBrowse link
G H4f16 H4 histone 16 decreases expression ISO Alitretinoin results in decreased expression of H4F16 mRNA CTD PMID:16392701 NCBI chr17:43,821,122...43,821,587 JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Alitretinoin results in increased expression of HBEGF mRNA CTD PMID:15982314 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hgf hepatocyte growth factor decreases expression
decreases secretion
increases expression
increases secretion
ISO Alitretinoin results in decreased expression of HGF mRNA
Alitretinoin results in decreased secretion of HGF protein
Alitretinoin results in increased expression of HGF mRNA
Alitretinoin results in increased secretion of HGF protein
CTD PMID:11223164, PMID:16192631 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP Alitretinoin results in decreased expression of HNF4A mRNA CTD PMID:21115832 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO Alitretinoin results in decreased expression of HNRNPA2B1 protein CTD PMID:28886987 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase increases expression EXP Alitretinoin results in increased expression of HPGDS mRNA CTD PMID:16648578 NCBI chr 4:95,945,356...95,970,666
Ensembl chr 4:95,946,025...95,970,666
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Alitretinoin results in decreased expression of HSD11B1 mRNA CTD PMID:15982314 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases activity
increases expression
ISO Alitretinoin results in increased activity of HSD17B1 protein
Alitretinoin results in increased expression of HSD17B1 mRNA
CTD PMID:16513093 NCBI chr10:88,987,558...88,989,758
Ensembl chr10:88,987,558...88,989,757
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression EXP Alitretinoin results in decreased expression of HSPH1 mRNA CTD PMID:16648578 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
decreases expression
ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]; [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]
Alitretinoin results in decreased secretion of IFNG protein
Alitretinoin results in decreased expression of IFNG mRNA; Alitretinoin results in decreased expression of IFNG protein
CTD PMID:11970994, PMID:17118196, PMID:21268089 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Alitretinoin results in increased expression of IFNGR1 protein CTD PMID:16085646 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
increases expression
ISO Alitretinoin results in decreased expression of IGF1 protein
Alitretinoin results in increased expression of IGF1 mRNA
CTD PMID:15982314, PMID:15994153 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Alitretinoin results in increased expression of IGFBP2 mRNA CTD PMID:16648578 NCBI chr 9:80,118,029...80,144,804
Ensembl chr 9:80,118,029...80,144,789
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects binding
increases expression
ISO [Alitretinoin binds to RARB protein] which binds to IGFBP3 promoter
Alitretinoin results in increased expression of IGFBP3 mRNA; Alitretinoin results in increased expression of IGFBP3 protein
CTD PMID:15994153, PMID:16760641 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha decreases expression ISO Alitretinoin results in decreased expression of IL10RA mRNA CTD PMID:15982314 NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Alitretinoin results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:17118196, PMID:17475839 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Alitretinoin results in decreased expression of [IL12A protein binds to IL12B protein]
Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:16303184, PMID:17118196, PMID:17475839 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 increases expression ISO Alitretinoin results in increased expression of IL13 mRNA; Alitretinoin results in increased expression of IL13 protein CTD PMID:17118196 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Alitretinoin results in increased expression of IL1B mRNA
CTD PMID:15968640, PMID:15982314, PMID:16303184 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO Alitretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]
Alitretinoin results in decreased expression of IL2 mRNA; Alitretinoin results in decreased expression of IL2 protein
CTD PMID:12421932, PMID:17118196 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il24 interleukin 24 decreases expression ISO Alitretinoin results in decreased expression of IL24 mRNA CTD PMID:15982314 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
increases secretion
ISO Alitretinoin results in increased expression of IL4 mRNA; Alitretinoin results in increased expression of IL4 protein
IL4 protein promotes the reaction [Alitretinoin results in increased secretion of IL4 protein]
CTD PMID:11970994, PMID:17118196 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 increases expression ISO Alitretinoin results in increased expression of IL5 mRNA; Alitretinoin results in increased expression of IL5 protein CTD PMID:17118196 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:15968640 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]
[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA; [[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased uptake of Oleic Acid; [Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased susceptibility to Alitretinoin; Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA]
CTD PMID:10777552, PMID:11348869 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor increases phosphorylation EXP Alitretinoin results in increased phosphorylation of INSR protein CTD PMID:18063688 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO Alitretinoin results in increased expression of IRF1; Alitretinoin results in increased expression of IRF1 mRNA; Alitretinoin results in increased expression of IRF1 protein CTD PMID:16085646, PMID:16636311, PMID:17229644 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression ISO Alitretinoin results in increased expression of ITGA4 mRNA CTD PMID:15982314 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of ITGAM protein]; Vitamin D promotes the reaction [Alitretinoin results in increased expression of ITGAM protein] CTD PMID:15964820 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of ITGAX protein]; Vitamin D promotes the reaction [Alitretinoin results in increased expression of ITGAX protein] CTD PMID:15964820 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of ITGB2 protein] CTD PMID:15964820 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Ivl involucrin increases expression
decreases expression
ISO Alitretinoin results in increased expression of IVL mRNA
Alitretinoin results in decreased expression of IVL mRNA
CTD PMID:8853895, PMID:17034753 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Alitretinoin co-treated with Tretinoin co-treated with Calcitriol] results in increased expression of JUN protein; Alitretinoin inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:8950452, PMID:19812349 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Klk10 kallikrein related-peptidase 10 increases expression ISO Alitretinoin results in increased expression of KLK10 mRNA; Alitretinoin results in increased expression of KLK10 protein CTD PMID:16800735 NCBI chr 1:99,718,275...99,722,743
Ensembl chr 1:99,718,907...99,722,284
JBrowse link
G Krt1 keratin 1 decreases expression ISO Alitretinoin results in decreased expression of KRT1 mRNA CTD PMID:15982314 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 decreases expression ISO Alitretinoin results in decreased expression of KRT10 mRNA CTD PMID:15982314 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Krt14 keratin 14 decreases expression ISO Alitretinoin results in decreased expression of KRT14 mRNA CTD PMID:8853895, PMID:15982314 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Krt15 keratin 15 increases expression ISO Alitretinoin results in increased expression of KRT15 mRNA CTD PMID:15982314 NCBI chr10:88,046,803...88,050,622
Ensembl chr10:88,046,803...88,050,622
JBrowse link
G Krt17 keratin 17 decreases expression ISO Alitretinoin results in decreased expression of KRT17 mRNA CTD PMID:15982314 NCBI chr10:88,158,993...88,163,712
Ensembl chr10:88,118,001...88,163,723
JBrowse link
G Krt18 keratin 18 increases expression ISO Alitretinoin results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression ISO Alitretinoin results in increased expression of KRT19 mRNA; Alitretinoin results in increased expression of KRT19 protein CTD PMID:11214822, PMID:15982314, PMID:17034753 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt5 keratin 5 decreases expression ISO Alitretinoin results in decreased expression of KRT5 mRNA CTD PMID:8853895, PMID:15982314 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Krt7 keratin 7 increases expression ISO Alitretinoin results in increased expression of KRT7 mRNA; Alitretinoin results in increased expression of KRT7 protein CTD PMID:15982314, PMID:17034753 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G Krt75 keratin 75 decreases expression ISO Alitretinoin results in decreased expression of KRT75 mRNA CTD PMID:15982314 NCBI chr 7:143,219,012...143,228,237
Ensembl chr 7:143,219,012...143,228,060
JBrowse link
G Krt8 keratin 8 increases expression ISO Alitretinoin results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lama2 laminin subunit alpha 2 decreases expression ISO Alitretinoin results in decreased expression of LAMA2 mRNA CTD PMID:15982314 NCBI chr 1:18,491,264...19,143,486
Ensembl chr 1:18,491,384...19,143,269
JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Alitretinoin results in decreased expression of LAMA3 mRNA CTD PMID:15982314 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lamc3 laminin subunit gamma 3 increases expression ISO Alitretinoin results in increased expression of LAMC3 mRNA CTD PMID:15982314 NCBI chr 3:9,265,407...9,327,107
Ensembl chr 3:9,267,122...9,326,993
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Alitretinoin results in increased expression of LCN2 mRNA CTD PMID:15982314 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lep leptin multiple interactions EXP [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases expression
ISO [Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of LPL mRNA; [Alitretinoin co-treated with TO-901317] results in increased expression of LPL mRNA
Alitretinoin results in increased expression of LPL mRNA
CTD PMID:16142410 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lypla1 lysophospholipase 1 decreases expression EXP Alitretinoin results in decreased expression of LYPLA1 mRNA CTD PMID:16648578 NCBI chr 5:14,559,333...14,588,447
Ensembl chr 5:14,559,334...14,588,422
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Alitretinoin results in increased expression of MAP2 protein CTD PMID:23500671 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Alitretinoin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of MAPK1 protein
CTD PMID:16043492, PMID:16611854 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of MAPK3 protein
Alitretinoin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
CTD PMID:16043492, PMID:16611854 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 increases expression EXP Alitretinoin results in increased expression of MARK1 mRNA CTD PMID:16648578 NCBI chr13:102,808,254...102,942,863
Ensembl chr13:102,808,253...102,942,863
JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO Alitretinoin results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO Alitretinoin results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO Alitretinoin results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases phosphorylation ISO Alitretinoin results in increased phosphorylation of MET protein CTD PMID:16192631 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mfap2 microfibril associated protein 2 decreases expression ISO Alitretinoin results in decreased expression of MFAP2 mRNA CTD PMID:15982314 NCBI chr 5:159,534,202...159,539,750
Ensembl chr 5:159,534,202...159,539,750
JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Alitretinoin results in increased expression of MITF mRNA CTD PMID:23489423 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Alitretinoin results in decreased expression of MMP10 mRNA CTD PMID:15982314 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of MTOR protein CTD PMID:16611854 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO Alitretinoin results in increased expression of MTTP mRNA CTD PMID:15537571 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO Alitretinoin results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; [Alitretinoin co-treated with NCOA1 protein] results in increased activity of RXRB protein; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein] CTD PMID:17223708, PMID:22227104 NCBI chr 6:28,677,563...28,931,844
Ensembl chr 6:28,677,540...28,931,843
JBrowse link
G Ndufaf3 NADH:ubiquinone oxidoreductase complex assembly factor 3 increases expression EXP Alitretinoin results in increased expression of NDUFAF3 mRNA CTD PMID:16648578 NCBI chr 8:117,351,628...117,353,460
Ensembl chr 8:117,351,629...117,353,672
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Alitretinoin results in increased expression of NEDD9 mRNA CTD PMID:15982314 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nefh neurofilament heavy increases expression ISO Alitretinoin results in increased expression of NEFH protein CTD PMID:23500671 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nefl neurofilament light decreases expression ISO Alitretinoin results in decreased expression of NEFL mRNA CTD PMID:15982314 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium increases expression ISO Alitretinoin results in increased expression of NEFM protein CTD PMID:8892963 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased activity of NFE2L2 protein CTD PMID:15150131 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nkx3-1 NK3 homeobox 1 increases expression ISO Alitretinoin results in increased expression of NKX3-1 mRNA; Alitretinoin results in increased expression of NKX3-1 protein CTD PMID:16763719 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 decreases expression ISO Alitretinoin results in decreased expression of NME2 protein CTD PMID:28886987 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO Alitretinoin results in decreased expression of NPM1 protein CTD PMID:28886987 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO [Alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H2 protein CTD PMID:16888799 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO [Alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H3 protein; Alitretinoin inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA] CTD PMID:16888799, PMID:21268089 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin binds to and results in increased activity of NR1I3 protein alternative form; Alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]
Alitretinoin results in increased activity of [RXRA protein binds to NR1I3 protein]
CTD PMID:17223708, PMID:19686701, PMID:31312845 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions
decreases expression
ISO Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA]
Alitretinoin results in decreased expression of NR5A2 mRNA
CTD PMID:16357189 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Nrl neural retina leucine zipper increases expression ISO Alitretinoin results in increased expression of NRL mRNA; Alitretinoin results in increased expression of NRL protein CTD PMID:16854989 NCBI chr15:34,197,115...34,201,408
Ensembl chr15:34,197,193...34,198,921
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO Alitretinoin results in decreased expression of ODC1 mRNA CTD PMID:15982314 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Alitretinoin results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G P2rx2 purinergic receptor P2X 2 increases expression EXP Alitretinoin results in increased expression of P2RX2 mRNA; Alitretinoin results in increased expression of P2RX2 protein CTD PMID:16638968 NCBI chr12:52,397,666...52,401,005
Ensembl chr12:52,397,792...52,401,015
JBrowse link
G Padi4 peptidyl arginine deiminase 4 multiple interactions
increases expression
ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of PADI4 mRNA] CTD PMID:15964820 NCBI chr 5:159,260,675...159,293,906
Ensembl chr 5:159,260,675...159,293,673
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Alitretinoin results in increased cleavage of PARP1 protein CTD PMID:16449964 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions
EXP
ISO
Alitretinoin results in increased expression of PCK1 mRNA
[Tretinoin co-treated with Alitretinoin] affects the reaction [Vitamin A affects the expression of PCK1 mRNA]
CTD PMID:16317119, PMID:17320364 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Alitretinoin results in increased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein] CTD PMID:11348869 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases expression ISO
EXP
Alitretinoin results in decreased expression of PDX1 mRNA CTD PMID:21115832, PMID:21670153 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Alitretinoin results in increased expression of PER1 mRNA CTD PMID:17069763 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Pex19 peroxisomal biogenesis factor 19 decreases expression EXP Alitretinoin results in decreased expression of PEX19 mRNA CTD PMID:16648578 NCBI chr13:90,514,324...90,530,825
Ensembl chr13:90,514,336...90,530,349
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Alitretinoin results in increased expression of PIK3R1 mRNA; Alitretinoin results in increased expression of PIK3R1 protein CTD PMID:16288212 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 increases expression EXP Alitretinoin results in increased expression of PIK3R3 mRNA CTD PMID:16648578 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pir pirin increases expression ISO Alitretinoin results in increased expression of PIR mRNA CTD PMID:15982314 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Alitretinoin results in decreased expression of PKM protein CTD PMID:28886987 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Alitretinoin results in increased expression of PLAT mRNA CTD PMID:15982314 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA CTD PMID:16292757 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
ISO
EXP
Alitretinoin results in increased activity of PPARG protein
[9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]; Alitretinoin binds to and results in increased activity of PPARG protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Alitretinoin results in increased activity of PPARG protein]; MG 262 promotes the reaction [Alitretinoin results in increased activity of PPARG protein]
[Pioglitazone co-treated with Alitretinoin] inhibits the reaction [PPARG protein results in increased susceptibility to Methamphetamine]; PPARG protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]
CTD PMID:15150131, PMID:15707588, PMID:16513826, PMID:17019405, PMID:18063688 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO Alitretinoin results in increased expression of PPARGC1A mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; PPARG protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; RXRA protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]
CTD PMID:16513826 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator multiple interactions ISO Alitretinoin promotes the reaction [RARA protein binds to PRAME protein] CTD PMID:16179254 NCBI chr  X:106,082,984...106,091,256
Ensembl chr  X:106,083,203...106,085,878
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Alitretinoin results in decreased expression of PTGS1 mRNA CTD PMID:15982314 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Alitretinoin results in decreased expression of PTGS2 mRNA CTD PMID:15982314 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of PTHLH mRNA
Alitretinoin promotes the reaction [Calcitriol results in decreased expression of PTHLH mRNA]
CTD PMID:16243370 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression EXP Alitretinoin results in increased expression of RAB11B mRNA CTD PMID:16648578 NCBI chr 7:18,598,991...18,612,132
Ensembl chr 7:18,598,880...18,612,147
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases response to substance
decreases expression
ISO RAB27A gene mutant form results in decreased susceptibility to Alitretinoin
Alitretinoin results in decreased expression of RAB27A mRNA
CTD PMID:16449964 NCBI chr 8:79,722,334...79,776,228
Ensembl chr 8:79,722,334...79,776,221
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
multiple interactions
decreases expression
EXP
ISO
Alitretinoin results in increased expression of RARA protein
[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]; CAMK4 protein promotes the reaction [Alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; Okadaic Acid promotes the reaction [Alitretinoin results in increased activity of RARA protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; trichostatin A promotes the reaction [Alitretinoin results in increased activity of RARA protein]
Alitretinoin results in decreased expression of RARA protein
Alitretinoin results in increased expression of RARA mRNA
Alitretinoin binds to and results in increased activity of RARA protein; Alitretinoin promotes the reaction [RARA protein binds to PRAME protein]; RARA protein promotes the reaction [Alitretinoin results in increased expression of ABCC6 mRNA]
CTD PMID:8892963, PMID:11139446, PMID:15375546, PMID:15773917, PMID:16043492, PMID:16179254, PMID:17034753, PMID:17045963, PMID:18180267 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rarb retinoic acid receptor, beta affects binding
multiple interactions
increases expression
ISO [Alitretinoin binds to RARB protein] which binds to IGFBP3 promoter
Alitretinoin binds to [RXRA protein binds to RARB protein]
[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA; sodium arsenite inhibits the reaction [[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]
Alitretinoin binds to and results in increased activity of RARB protein
Alitretinoin results in increased expression of RARB mRNA
Alitretinoin results in increased expression of RARB mRNA; Alitretinoin results in increased expression of RARB protein
CTD PMID:8892963, PMID:11139446, PMID:15159591, PMID:15375546, PMID:16413115, PMID:16760641, PMID:18180267, PMID:22310326 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression
multiple interactions
decreases response to substance
ISO Alitretinoin results in decreased expression of RARG protein
Alitretinoin binds to and results in increased activity of RARG protein
RARG gene mutant form results in decreased susceptibility to Alitretinoin
CTD PMID:10748128, PMID:15375546, PMID:15615532, PMID:18180267, PMID:19812349 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO Alitretinoin results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:164,650,722...164,684,982
Ensembl chr 2:164,650,722...164,684,985
JBrowse link
G Rasl11a RAS-like family 11 member A increases expression EXP Alitretinoin results in increased expression of RASL11A mRNA CTD PMID:16648578 NCBI chr12:9,986,150...9,990,284
Ensembl chr12:9,985,928...9,990,284
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]
Alitretinoin results in decreased phosphorylation of RB1 protein
CTD PMID:11348869, PMID:16273314 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbp1 retinol binding protein 1 increases abundance ISO RBP1 gene mutant form results in increased abundance of Alitretinoin CTD PMID:21670153 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rbp2 retinol binding protein 2 increases expression EXP Alitretinoin results in increased expression of RBP2 mRNA CTD PMID:19409899 NCBI chr 8:106,479,253...106,527,726
Ensembl chr 8:106,503,504...106,527,711
JBrowse link
G Rest RE1-silencing transcription factor increases expression EXP Alitretinoin results in increased expression of REST mRNA CTD PMID:16648578 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
G Retn resistin decreases expression
decreases secretion
ISO Alitretinoin results in decreased expression of RETN mRNA
Alitretinoin results in decreased secretion of RETN protein
CTD PMID:15047602 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Alitretinoin results in decreased expression of RHOA mRNA CTD PMID:15982314 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhob ras homolog family member B decreases expression ISO Alitretinoin results in decreased expression of RHOB mRNA CTD PMID:15982314 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Rnf5 ring finger protein 5 decreases expression ISO Alitretinoin results in decreased expression of RNF5 mRNA CTD PMID:15982314 NCBI chr20:4,366,244...4,368,690
Ensembl chr20:4,366,246...4,368,693
JBrowse link
G Rpl22 ribosomal protein L22 increases expression EXP Alitretinoin results in increased expression of RPL22 mRNA CTD PMID:16648578 NCBI chr 5:169,506,150...169,512,875
Ensembl chr 5:169,506,138...169,512,871
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of RPS6KA1 protein CTD PMID:16611854 NCBI chr 5:152,078,217...152,122,684
Ensembl chr 5:152,078,220...152,122,684
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
affects binding
increases ubiquitination
increases expression
increases degradation
decreases expression
affects localization
increases localization
ISO
EXP
[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA; Alitretinoin binds to and results in increased activity of RXRA protein; Alitretinoin inhibits the reaction [TGIF1 protein binds to RXRA protein]; Alitretinoin inhibits the reaction [TGIF1 protein results in increased activity of RXRA protein]; Alitretinoin results in increased activity of [RXRA protein binds to NR1I3 protein]; Alitretinoin results in increased activity of [RXRA protein binds to RXRA protein]; ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate inhibits the reaction [Alitretinoin results in increased activity of [RXRA protein binds to RXRA protein]]; RXRA protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; sodium arsenite inhibits the reaction [[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]
Alitretinoin binds to RXRA protein
Alitretinoin results in increased ubiquitination of RXRA protein
Alitretinoin binds to [RXRA protein binds to RARB protein]
Alitretinoin results in increased expression of RXRA protein
Alitretinoin binds to RXRA protein; RXRA protein binds to Alitretinoin
Alitretinoin results in increased degradation of RXRA protein
[9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]
Alitretinoin results in decreased expression of RXRA protein
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; [Alitretinoin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; [Alitretinoin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of RXRA protein; [Alitretinoin co-treated with Calcitriol] results in increased stability of [RXRA protein binds to VDR protein]; [Alitretinoin co-treated with RXRA protein] results in increased expression of PSG5 mRNA; [Alitretinoin results in increased activity of RXRA protein] which binds to PSG5 promoter; [pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA; Alitretinoin analog binds to and results in increased activity of RXRA protein; Alitretinoin binds to and affects the activity of RXRA protein; Alitretinoin binds to and results in increased activity of RXRA protein; Alitretinoin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; Alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Alitretinoin results in increased degradation of RXRA protein]; Flurbiprofen inhibits the reaction [Alitretinoin binds to RXRA protein]; RXRA promotes the reaction [Alitretinoin results in increased expression of APOA2 mRNA]; RXRA protein affects the reaction [Alitretinoin results in increased expression of CYP2B6 mRNA]; tributyltin inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyl bismuth inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenylarsine inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyltin chloride inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyltin hydroxide inhibits the reaction [Alitretinoin binds to RXRA protein]
Alitretinoin affects the localization of RXRA protein
Alitretinoin results in increased expression of RXRA mRNA
Alitretinoin results in increased localization of RXRA protein
CTD PMID:8668150, PMID:11139446, PMID:15150131, PMID:15159591, PMID:15375546, PMID:15866424, PMID:15941851, PMID:15997096, PMID:16043492, PMID:16184197, PMID:16204233, PMID:16258897, PMID:16292757, PMID:16428452, PMID:16460010, PMID:16513826, PMID:16632523, PMID:16946489, PMID:17084873, PMID:17170071, PMID:17223708, PMID:17475324, PMID:19659691, PMID:19686701, PMID:19812349, PMID:22310326, PMID:27725436, PMID:31195007, PMID:31312845, PMID:31566444 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Rxrb retinoid X receptor beta increases degradation
affects binding
increases activity
increases expression
multiple interactions
ISO
EXP
Alitretinoin results in increased degradation of RXRB protein
Alitretinoin binds to RXRB protein
Alitretinoin results in increased activity of RXRB protein
Alitretinoin results in increased expression of RXRB protein
2,4,6-trichlorophenol inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]; [Alitretinoin co-treated with NCOA1 protein] results in increased activity of RXRB protein; Alitretinoin binds to and affects the activity of RXRB protein; Alitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]; bisphenol A analog inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]; bisphenol A inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]; tetrachlorodian inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]
CTD PMID:11939783, PMID:12898515, PMID:15941851, PMID:16043492, PMID:18207673, PMID:22227104, PMID:27565853, PMID:31195007 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
G Rxrg retinoid X receptor gamma increases expression
multiple interactions
decreases expression
affects activity
affects binding
ISO Alitretinoin results in increased expression of RXRG mRNA
Alitretinoin binds to and affects the activity of RXRG protein
Alitretinoin results in decreased expression of RXRG mRNA
Alitretinoin affects the activity of RXRG protein
Alitretinoin binds to RXRG protein
CTD PMID:8892963, PMID:9092800, PMID:11139446, PMID:12114515, PMID:15941851, PMID:31195007 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO Alitretinoin results in decreased expression of S100A1 mRNA CTD PMID:15982314 NCBI chr 2:189,900,505...189,905,348
Ensembl chr 2:189,900,667...189,903,219
JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression ISO Alitretinoin results in decreased expression of S100A8 mRNA CTD PMID:15982314 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Alitretinoin results in increased expression of S100A9 mRNA CTD PMID:15982314 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Alitretinoin results in increased expression of SCARB1 mRNA CTD PMID:16142410 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Alitretinoin results in increased expression of SCD mRNA CTD PMID:11397803 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sema6b semaphorin 6B multiple interactions ISO Alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B mRNA]; Alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B protein]; Alitretinoin promotes the reaction [Troglitazone results in decreased expression of SEMA6B mRNA]; Alitretinoin promotes the reaction [Troglitazone results in decreased expression of SEMA6B protein] CTD PMID:16525649 NCBI chr 9:10,934,273...10,951,252
Ensembl chr 9:10,941,613...10,951,252
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Alitretinoin results in increased expression of SERPINA3 mRNA CTD PMID:15982314 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO Alitretinoin results in decreased expression of SERPINB2 mRNA CTD PMID:15982314 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpinb8 serpin family B member 8 decreases expression ISO Alitretinoin results in decreased expression of SERPINB8 mRNA CTD PMID:15982314 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Serpinb9 serpin family B member 9 decreases expression ISO Alitretinoin results in decreased expression of SERPINB9 mRNA CTD PMID:15982314 NCBI chr17:32,648,846...32,673,047
Ensembl chr17:32,650,441...32,661,865
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Alitretinoin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] CTD PMID:16192631 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression ISO Alitretinoin results in decreased expression of SLC16A1 mRNA CTD PMID:15982314 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions
increases expression
ISO
EXP
[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA; Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA]
Alitretinoin results in increased expression of SLC27A1 mRNA
Dactinomycin inhibits the reaction [Alitretinoin results in increased expression of SLC27A1 mRNA]
CTD PMID:10777552 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases activity
decreases expression
EXP
ISO
Alitretinoin results in decreased activity of SLC2A2 protein
Alitretinoin results in decreased expression of SLC2A2 mRNA
CTD PMID:21115832, PMID:21670153 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Alitretinoin results in increased expression of SLC2A4 mRNA; Alitretinoin results in increased expression of SLC2A4 protein CTD PMID:16273324, PMID:18063688 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression ISO Alitretinoin results in increased expression of SLC5A5 mRNA CTD PMID:16954431 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [TO-901317 co-treated with Alitretinoin] results in increased expression of SMAD3 protein CTD PMID:17194744 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Snn stannin decreases expression EXP Alitretinoin results in decreased expression of SNN mRNA CTD PMID:16648578 NCBI chr10:4,635,897...4,644,570
Ensembl chr10:4,635,898...4,644,570
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO Alitretinoin results in decreased expression of SOCS1 mRNA CTD PMID:15982314 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO Alitretinoin results in increased expression of SOCS2 mRNA CTD PMID:15982314 NCBI chr 7:36,495,496...36,500,878
Ensembl chr 7:36,495,480...36,499,784
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Alitretinoin results in increased expression of SPINK1 mRNA CTD PMID:16648578 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression
increases expression
ISO Alitretinoin results in decreased expression of SPP1 mRNA
Alitretinoin results in increased expression of SPP1 mRNA
Alitretinoin results in decreased expression of SPP1 mRNA; Alitretinoin results in decreased expression of SPP1 protein
CTD PMID:11139446, PMID:16392701 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sprr1b small proline-rich protein 1B decreases expression ISO Alitretinoin results in decreased expression of SPRR1B mRNA CTD PMID:15982314 NCBI chr 2:192,622,972...192,624,848
Ensembl chr 2:192,623,244...192,623,681
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [Arsenic Trioxide results in decreased expression of SREBF1 protein] CTD PMID:27622732 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]; [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]; Alitretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein CTD PMID:16085646, PMID:21268089 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Sts steroid sulfatase increases activity ISO Alitretinoin results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO Alitretinoin results in decreased expression of SULT2A1 mRNA CTD PMID:15982314 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 increases expression ISO Alitretinoin results in increased expression of TACSTD2 mRNA CTD PMID:15982314 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 increases phosphorylation
multiple interactions
EXP Alitretinoin results in increased phosphorylation of TBC1D4 protein
Oligomycins promotes the reaction [Alitretinoin results in increased phosphorylation of TBC1D4 protein]
CTD PMID:18063688 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO Alitretinoin results in decreased expression of TERT mRNA CTD PMID:16180984 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases response to substance
decreases activity
decreases expression
ISO Alitretinoin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]
Alitretinoin results in decreased susceptibility to TGFB1 protein
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [Alitretinoin results in decreased expression of TGFB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA]
Alitretinoin results in decreased activity of TGFB1 protein
CTD PMID:16192631, PMID:16611854, PMID:21152098 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression ISO Alitretinoin results in increased expression of TGFB1I1 mRNA CTD PMID:15982314 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression
multiple interactions
ISO Alitretinoin results in increased expression of TGIF1 protein
Alitretinoin inhibits the reaction [TGIF1 protein binds to RXRA protein]; Alitretinoin inhibits the reaction [TGIF1 protein results in increased activity of RXRA protein]
CTD PMID:16192631, PMID:16428452 NCBI chr 9:119,181,079...119,190,698
Ensembl chr 9:119,181,083...119,190,698
JBrowse link
G Tgm1 transglutaminase 1 decreases expression ISO Alitretinoin results in decreased expression of TGM1 mRNA CTD PMID:8853895, PMID:15982314 NCBI chr15:34,378,136...34,393,150
Ensembl chr15:34,378,148...34,392,066
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
increases expression
increases activity
ISO [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H4-16 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 protein]; periodate-oxidized adenosine inhibits the reaction [Alitretinoin results in increased expression of TGM2 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]]; Vitamin D promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]
Alitretinoin results in increased expression of TGM2 mRNA; Alitretinoin results in increased expression of TGM2 protein
Alitretinoin results in increased activity of TGM2 protein
CTD PMID:9516142, PMID:15964820, PMID:16158052, PMID:17034753 NCBI chr 3:154,597,165...154,627,257
Ensembl chr 3:154,597,168...154,627,257
JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO Alitretinoin results in decreased expression of THBS1 mRNA CTD PMID:15982314 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Alitretinoin results in decreased expression of TNF mRNA; Alitretinoin results in decreased expression of TNF protein
Alitretinoin inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]; Alitretinoin inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]
CTD PMID:15968640, PMID:16303184, PMID:17118196, PMID:19812349 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Alitretinoin results in increased expression of TNFRSF10A mRNA CTD PMID:16449964 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Alitretinoin results in increased expression of TNFSF10 mRNA; Alitretinoin results in increased expression of TNFSF10 protein CTD PMID:16449964 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression ISO Alitretinoin results in decreased expression of TSHB mRNA; Alitretinoin results in decreased expression of TSHB protein CTD PMID:9092800, PMID:16306084 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Ttr transthyretin decreases expression EXP Alitretinoin results in decreased expression of TTR mRNA CTD PMID:16648578 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP Alitretinoin results in increased expression of TUBA1A mRNA CTD PMID:16648578 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Tyr tyrosinase increases expression ISO Alitretinoin results in increased expression of TYR mRNA; Alitretinoin results in increased expression of TYR protein CTD PMID:23489423 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions
EXP
ISO
Alitretinoin results in increased expression of UCP1 mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Alitretinoin results in increased expression of UCP1 mRNA]; Glutathione inhibits the reaction [Alitretinoin results in increased expression of UCP1 mRNA]
CTD PMID:10600643, PMID:12414803 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase multiple interactions ISO [pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA CTD PMID:16292757 NCBI chr14:44,479,614...44,502,845
Ensembl chr14:44,479,614...44,502,845
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Alitretinoin results in increased expression of UGT1A1 mRNA CTD PMID:14620509 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression EXP Alitretinoin results in increased expression of UGT1A2 mRNA CTD PMID:14620509 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP Alitretinoin results in increased expression of UGT1A5 mRNA CTD PMID:14620509 NCBI chr 9:95,274,707...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP Alitretinoin results in decreased expression of UGT1A6 mRNA CTD PMID:14620509 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP Alitretinoin results in decreased expression of UGT2B mRNA CTD PMID:16648578 Ensembl chr14:22,375,955...22,534,720 JBrowse link
G Uvrag UV radiation resistance associated decreases expression ISO Alitretinoin results in decreased expression of UVRAG mRNA CTD PMID:15982314 NCBI chr 1:163,844,804...164,101,568
Ensembl chr 1:163,844,818...164,101,578
JBrowse link
G Vdr vitamin D receptor multiple interactions
affects activity
increases degradation
ISO [Alitretinoin co-treated with Calcitriol] results in increased stability of [RXRA protein binds to VDR protein]; Alitretinoin promotes the reaction [VDR protein binds to BGLAP gene]
Alitretinoin affects the activity of VDR protein
Alitretinoin results in increased degradation of VDR protein
CTD PMID:12898515, PMID:16204233, PMID:16936639 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Alitretinoin results in increased expression of VEGFA mRNA CTD PMID:16386082 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Alitretinoin results in decreased expression of VEGFC mRNA CTD PMID:15982314 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of VIM mRNA; Alitretinoin results in decreased expression of VIM protein
[Tretinoin co-treated with Alitretinoin] results in decreased expression of VIM mRNA; Tretinoin promotes the reaction [Alitretinoin results in decreased expression of VIM protein]
CTD PMID:28886987, PMID:31634547 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 multiple interactions ISO Alitretinoin inhibits the reaction [GW 4064 results in increased expression of VIPR1] CTD PMID:16037943 NCBI chr 8:130,283,453...130,313,431 JBrowse link
G Wnt5b Wnt family member 5B decreases expression ISO Alitretinoin results in decreased expression of WNT5B mRNA CTD PMID:15972578 NCBI chr 4:151,500,962...151,516,894
Ensembl chr 4:151,500,957...151,516,894
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            9-cis-retinoic acid 295
              9-cis-4-hydroxyretinoic acid 0
              9-cis-4-oxoretinoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          alpha,beta-unsaturated monocarboxylic acid 11372
                                            retinoic acid 7655
                                              9-cis-retinoic acid 295
                                                9-cis-4-hydroxyretinoic acid 0
                                                9-cis-4-oxoretinoic acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.