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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:9-cis-retinoic acid
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Accession:CHEBI:50648 term browser browse the term
Definition:A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Synonyms:exact_synonym: (9cis)-retinoic acid
 related_synonym: (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid;   (7E,9Z,11E,13E)-retinoic acid;   9(Z)-Retinoic acid;   9-cis-Tretinoin;   Alitretinoin;   Formula=C20H28O2;   InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+;   InChIKey=SHGAZHPCJJPHSC-ZVCIMWCZSA-N;   Panretin;   SMILES=CC(\\C=C\\C1=C(C)CCCC1(C)C)=C\\C=C\\C(C)=C\\C(O)=O;   alitretinoina;   alitretinoine;   alitretinoinum
 alt_id: CHEBI:63793
 xref: CAS:5300-03-8;   DrugBank:DB00523;   Drug_Central:3862;   HMDB:HMDB0002369;   KEGG:C15493;   KEGG:D02815;   LIPID_MAPS_instance:LMPR01090022
 xref_mesh: MESH:C103303
 xref: PMID:10684759;   PMID:11978340;   PMID:12611604;   PMID:12882648;   PMID:15217968;   PMID:15292987;   PMID:15519497;   PMID:16144296;   PMID:17019405;   PMID:18400206;   PMID:18404486;   PMID:19678713;   PMID:7670094;   Reaxys:2057222;   Wikipedia:Alitretinoin
 cyclic_relationship: is_conjugate_acid_of CHEBI:78630


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9-cis-retinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO
EXP
3-aminobenzamide promotes the reaction [Alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]]; 3-aminobenzamide promotes the reaction [Alitretinoin results in increased expression of ABCA1 mRNA]; Alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 mRNA]; Alitretinoin promotes the reaction [TO-901317 results in increased expression of ABCA1 protein]; TO-901317 promotes the reaction [Alitretinoin results in increased expression of ABCA1 mRNA]
[22-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 mRNA; [22-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein
[22-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein; [25-hydroxycholesterol co-treated with Alitretinoin] results in increased expression of ABCA1 protein; [Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA; [Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein; Arsenic Trioxide inhibits the reaction [[Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 mRNA]; Arsenic Trioxide inhibits the reaction [[Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of ABCA1 protein]
CTD PMID:16023994 PMID:16184197 PMID:17478430 PMID:27026705 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Alitretinoin results in increased expression of ABCC3 mRNA CTD PMID:15824121 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases expression
ISO RARA protein promotes the reaction [Alitretinoin results in increased expression of ABCC6 mRNA] CTD PMID:17045963 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression EXP Alitretinoin results in increased expression of ABCD3 mRNA CTD PMID:16648578 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
ISO [TO-901317 co-treated with Alitretinoin] results in increased expression of ABCG1 mRNA
Alitretinoin results in increased expression of ABCG1 mRNA
CTD PMID:16024918 PMID:16730733 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Alitretinoin results in increased expression of ACOT2 mRNA CTD PMID:16648578 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions
EXP Alitretinoin results in increased expression of ACTA2 mRNA
15-deoxyprostaglandin J2 inhibits the reaction [Alitretinoin results in increased expression of ACTA2 mRNA]; Alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of ACTA2 mRNA]
CTD PMID:17161435 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Alitretinoin results in decreased expression of ACTG2 protein CTD PMID:16043492 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
JBrowse link
G Adipor1 adiponectin receptor 1 multiple interactions ISO [25-hydroxycholesterol co-treated with Alitretinoin] results in decreased expression of ADIPOR1 mRNA CTD PMID:16023994 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
JBrowse link
G Ahsg alpha-2-HS-glycoprotein decreases expression EXP Alitretinoin results in decreased expression of AHSG mRNA CTD PMID:16648578 NCBI chr11:78,117,903...78,145,956 JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein decreases expression ISO Alitretinoin results in decreased expression of AIP mRNA CTD PMID:15982314 NCBI chr 1:201,407,287...201,419,220
Ensembl chr 1:201,407,288...201,419,122
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions
ISO
EXP
Alitretinoin results in decreased phosphorylation of AKT1 protein
Alitretinoin results in increased phosphorylation of AKT1 protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of AKT1 protein
CTD PMID:16288212 PMID:16340750 PMID:16611854 PMID:18063688 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Anxa1 annexin A1 decreases expression ISO Alitretinoin results in decreased expression of ANXA1 protein CTD PMID:28886987 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa2 annexin A2 decreases expression ISO Alitretinoin results in decreased expression of ANXA2 protein CTD PMID:28886987 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Anxa5 annexin A5 decreases expression ISO Alitretinoin results in decreased expression of ANXA5 protein CTD PMID:28886987 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apoa2 apolipoprotein A2 increases expression
multiple interactions
ISO Alitretinoin results in increased expression of APOA2 mRNA
RXRA promotes the reaction [Alitretinoin results in increased expression of APOA2 mRNA]
CTD PMID:8668150 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B increases expression EXP Alitretinoin results in increased expression of ARPC1B mRNA CTD PMID:16648578 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Alitretinoin results in decreased expression of ATP1B1 mRNA CTD PMID:16648578 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Alitretinoin results in increased expression of BAX; Alitretinoin results in increased expression of BAX protein
seocalcitol inhibits the reaction [Alitretinoin results in increased expression of BAX protein]
CTD PMID:12189556 PMID:16109544 PMID:16340750 PMID:16909596 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
decreases response to substance
ISO Alitretinoin results in decreased expression of BCL2; Alitretinoin results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Alitretinoin
CTD PMID:12189556 PMID:16109544 PMID:16909596 PMID:17077328 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO seocalcitol inhibits the reaction [Alitretinoin results in increased expression of BCL2L11 protein] CTD PMID:16340750 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bco1 beta-carotene oxygenase 1 decreases expression EXP Alitretinoin results in decreased expression of BCO1 mRNA CTD PMID:16699835 NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
decreases expression
ISO [Calcitriol co-treated with Alitretinoin] results in increased expression of BGLAP mRNA; [Calcitriol co-treated with Alitretinoin] results in increased secretion of BGLAP protein; [KH 1060 co-treated with Alitretinoin] results in increased expression of BGLAP mRNA; [KH 1060 co-treated with Alitretinoin] results in increased secretion of BGLAP protein; Alitretinoin promotes the reaction [Calcitriol results in increased expression of BGLAP mRNA]; Alitretinoin promotes the reaction [Calcitriol results in increased secretion of BGLAP protein]; Alitretinoin promotes the reaction [KH 1060 results in increased expression of BGLAP mRNA]; Alitretinoin promotes the reaction [KH 1060 results in increased secretion of BGLAP protein]; Alitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]; Alitretinoin promotes the reaction [VDR protein binds to BGLAP gene]
Alitretinoin results in decreased expression of BGLAP mRNA
CTD PMID:12898515 PMID:16392701 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma increases expression EXP Alitretinoin results in increased expression of CAMK2G mRNA CTD PMID:16648578 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV multiple interactions EXP CAMK4 protein promotes the reaction [Alitretinoin results in increased activity of RARA protein] CTD PMID:15773917 NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
JBrowse link
G Capn1 calpain 1 decreases expression ISO Alitretinoin results in decreased expression of CAPN1 mRNA CTD PMID:17460283 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
JBrowse link
G Capn2 calpain 2 decreases expression ISO Alitretinoin results in decreased expression of CAPN2 mRNA CTD PMID:17460283 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
increases expression
ISO [Alitretinoin co-treated with seocalcitol] results in increased expression of CA2 protein
Alitretinoin results in increased expression of CA2 protein
CTD PMID:16340750 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
ISO
EXP
Alitretinoin results in increased expression of CASP3; Alitretinoin results in increased expression of CASP3 protein
[TO-901317 co-treated with Alitretinoin] promotes the reaction [Palmitic Acid results in increased activity of CASP3 protein]
CTD PMID:16109544 PMID:16909596 PMID:17194744 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions EXP [TO-901317 co-treated with Alitretinoin] promotes the reaction [Palmitic Acid results in increased activity of CASP7 protein] CTD PMID:17194744 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Alitretinoin results in increased activity of CASP8 protein CTD PMID:16449964 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cbx3 chromobox 3 decreases expression ISO Alitretinoin results in decreased expression of CBX3 mRNA CTD PMID:15982314 NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]] CTD PMID:21268089 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein] CTD PMID:11348869 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Alitretinoin results in decreased expression of CCND3 protein CTD PMID:16273314 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of CCR2 mRNA; Alitretinoin results in decreased expression of CCR2 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Alitretinoin results in decreased expression of CCR2 mRNA]
CTD PMID:16712875 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO Alitretinoin results in increased expression of CCR3 mRNA CTD PMID:16712875 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression
decreases expression
ISO Alitretinoin results in increased expression of CCR7 protein
Alitretinoin results in decreased expression of CCR7 protein
CTD PMID:17475839 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd36 CD36 molecule decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of CD36 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in decreased expression of CD36 protein]; [Alitretinoin co-treated with Rosiglitazone] results in increased expression of CD36 protein; HX 630 inhibits the reaction [Alitretinoin results in decreased expression of CD36 protein]
CTD PMID:17475839 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd37 CD37 molecule increases expression EXP Alitretinoin results in increased expression of CD37 mRNA CTD PMID:16648578 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648
JBrowse link
G Cd38 CD38 molecule increases expression
multiple interactions
ISO Alitretinoin results in increased expression of CD38 mRNA
Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CD38 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CD38 mRNA]]
CTD PMID:15964820 PMID:21393419 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd80 Cd80 molecule decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of CD80 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in decreased expression of CD80 protein]; [Alitretinoin co-treated with Rosiglitazone] results in decreased expression of CD80 protein; HX 630 inhibits the reaction [Alitretinoin results in decreased expression of CD80 protein]
CTD PMID:17475839 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cd83 CD83 molecule increases expression ISO Alitretinoin results in increased expression of CD83 protein CTD PMID:17475839 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule increases expression
multiple interactions
ISO Alitretinoin results in increased expression of CD86 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in increased expression of CD86 protein]; [Alitretinoin co-treated with Rosiglitazone] results in increased expression of CD86 protein; HX 630 inhibits the reaction [Alitretinoin results in increased expression of CD86 protein]
CTD PMID:17475839 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdh1 cadherin 1 affects expression ISO Alitretinoin affects the expression of CDH1 mRNA CTD PMID:17034753 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Alitretinoin results in decreased expression of CDKN1A protein CTD PMID:16340750 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases stability
multiple interactions
increases expression
ISO Alitretinoin results in increased stability of CDKN1B protein
Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]; seocalcitol inhibits the reaction [Alitretinoin results in increased expression of CDKN1B protein]
CTD PMID:11348869 PMID:16340750 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Alitretinoin results in decreased expression of CDKN1C mRNA CTD PMID:15982314 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased activity of CEBPB protein CTD PMID:15150131 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 decreases expression EXP Alitretinoin results in decreased expression of CIAO1 mRNA CTD PMID:16648578 NCBI chr 3:114,458,671...114,465,928
Ensembl chr 3:114,458,655...114,467,009
JBrowse link
G Ciita class II, major histocompatibility complex, transactivator increases expression ISO Alitretinoin results in increased expression of CIITA mRNA CTD PMID:17229644 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440
JBrowse link
G Cnn1 calponin 1 multiple interactions
increases expression
EXP 15-deoxyprostaglandin J2 inhibits the reaction [Alitretinoin results in increased expression of CNN1 mRNA]; Alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of CNN1 mRNA] CTD PMID:17161435 NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098
JBrowse link
G Col12a1 collagen type XII alpha 1 chain decreases expression EXP Alitretinoin results in decreased expression of COL12A1 mRNA CTD PMID:16648578 NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686
JBrowse link
G Col17a1 collagen type XVII alpha 1 chain decreases expression ISO Alitretinoin results in decreased expression of COL17A1 mRNA CTD PMID:15982314 NCBI chr 1:246,530,589...246,577,632
Ensembl chr 1:246,531,367...246,577,632
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Alitretinoin results in increased expression of COL1A1 mRNA CTD PMID:17034753 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression EXP Alitretinoin results in increased expression of COL1A2 mRNA CTD PMID:16648578 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Col4a2 collagen type IV alpha 2 chain increases expression ISO Alitretinoin results in increased expression of COL4A2 mRNA CTD PMID:17034753 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839
JBrowse link
G Col6a1 collagen type VI alpha 1 chain decreases expression ISO Alitretinoin results in decreased expression of COL6A1 mRNA CTD PMID:15982314 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col8a2 collagen type VIII alpha 2 chain increases expression ISO Alitretinoin results in increased expression of COL8A2 mRNA CTD PMID:15982314 NCBI chr 5:138,586,201...138,613,627
Ensembl chr 5:138,585,999...138,612,850
JBrowse link
G Coro1b coronin 1B increases expression EXP Alitretinoin results in increased expression of CORO1B mRNA CTD PMID:16648578 NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
JBrowse link
G Crabp1 cellular retinoic acid binding protein 1 decreases response to substance ISO CRABP1 protein results in decreased susceptibility to Alitretinoin CTD PMID:16254461 NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 increases expression ISO
EXP
Alitretinoin results in increased expression of CRABP2 mRNA
Alitretinoin analog results in increased expression of CRABP2 mRNA; Alitretinoin results in increased expression of CRABP2 mRNA
CTD PMID:11214822 PMID:16339527 PMID:16946489 PMID:17034753 NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation ISO Alitretinoin results in increased phosphorylation of CREB1 protein CTD PMID:16280361 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression EXP Alitretinoin results in increased expression of CROT mRNA CTD PMID:16648578 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Alitretinoin results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression EXP Alitretinoin results in decreased expression of CXCL14 mRNA CTD PMID:16648578 NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Alitretinoin results in decreased expression of CXCL1 mRNA CTD PMID:15982314 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
EXP
ISO
Alitretinoin promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CYP19A1 mRNA]
Alitretinoin results in decreased expression of CYP19A1 mRNA
Alitretinoin results in increased expression of CYP19A1 mRNA
[Alitretinoin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA]
CTD PMID:12706301 PMID:15941851 PMID:16357189 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO Alitretinoin results in increased expression of CYP26A1 mRNA CTD PMID:16194896 PMID:16688765 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 multiple interactions
increases expression
increases metabolic processing
ISO Alitretinoin inhibits the reaction [CYP26C1 protein binds to and results in increased metabolism of Tretinoin]; CYP26C1 protein binds to and results in increased metabolism of Alitretinoin; Ketoconazole inhibits the reaction [CYP26C1 protein results in increased metabolism of Alitretinoin]
Alitretinoin results in increased expression of CYP26C1 mRNA
CYP26C1 results in increased metabolism of Alitretinoin
CTD PMID:14532297 PMID:21906690 NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression
decreases expression
multiple interactions
ISO Alitretinoin results in increased expression of CYP27A1 mRNA
Alitretinoin results in decreased expression of CYP27A1 mRNA
Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CYP27A1 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of CYP27A1 mRNA]]
CTD PMID:15964820 PMID:15982314 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO RXRA protein affects the reaction [Alitretinoin results in increased expression of CYP2B6 mRNA] CTD PMID:31312845 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions
ISO Alitretinoin results in increased activity of CYP3A4 protein
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]
CTD PMID:16632523 PMID:19686701 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp4f40 cytochrome P450, family 4, subfamily f, polypeptide 40 multiple interactions
decreases expression
ISO Alitretinoin inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]
Alitretinoin results in decreased expression of CYP4F11 mRNA; Alitretinoin results in decreased expression of CYP4F11 protein
CTD PMID:19812349 NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 increases expression ISO Alitretinoin results in increased expression of DHRS9 mRNA CTD PMID:11304534 NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity ISO Alitretinoin results in increased activity of DIO3 protein CTD PMID:16935842 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 decreases expression EXP Alitretinoin results in decreased expression of DNAJA1 mRNA CTD PMID:16648578 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dsc1 desmocollin 1 decreases expression ISO Alitretinoin results in decreased expression of DSC1 mRNA CTD PMID:15982314 NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Alitretinoin results in increased expression of DUSP10 mRNA CTD PMID:15982314 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp11 dual specificity phosphatase 11 decreases expression ISO Alitretinoin results in decreased expression of DUSP11 mRNA CTD PMID:15982314 NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Alitretinoin results in decreased expression of EGFR mRNA CTD PMID:15982314 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 decreases expression ISO Alitretinoin results in decreased expression of EIF4EBP2 mRNA CTD PMID:15982314 NCBI chr20:29,379,444...29,400,131
Ensembl chr20:29,382,668...29,399,946
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Alitretinoin results in increased expression of EMP1 mRNA CTD PMID:15982314 NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
ISO
EXP
Alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR1 mRNA]
Melatonin promotes the reaction [Alitretinoin results in decreased expression of ESR1 mRNA]
CTD PMID:16051031 PMID:19340624 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO Alitretinoin inhibits the reaction [Paclitaxel results in increased expression of ESR2 mRNA] CTD PMID:19340624 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Alitretinoin results in decreased expression of FABP5 mRNA CTD PMID:15982314 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fam3c FAM3 metabolism regulating signaling molecule C increases expression ISO Alitretinoin results in increased expression of FAM3C mRNA CTD PMID:15982314 NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078
JBrowse link
G Fas Fas cell surface death receptor decreases expression
increases expression
ISO Alitretinoin results in decreased expression of FAS mRNA
Alitretinoin results in increased expression of FAS mRNA
CTD PMID:16712844 PMID:17034753 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase decreases expression ISO Alitretinoin results in decreased expression of FASN mRNA CTD PMID:15982314 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO Alitretinoin results in decreased expression of FASTK mRNA CTD PMID:15982314 NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Alitretinoin results in increased expression of FDFT1 mRNA CTD PMID:16648578 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases expression ISO Alitretinoin results in decreased expression of FGF1 mRNA CTD PMID:15982314 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fhl1 four and a half LIM domains 1 increases expression
multiple interactions
EXP Alitretinoin results in increased expression of FHL1 mRNA
15-deoxyprostaglandin J2 inhibits the reaction [Alitretinoin results in increased expression of FHL1 mRNA]; Alitretinoin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA]
CTD PMID:17161435 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Flg filaggrin decreases expression ISO Alitretinoin results in decreased expression of FLG mRNA CTD PMID:15982314 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Fn1 fibronectin 1 increases expression
decreases expression
EXP
ISO
Alitretinoin results in increased expression of FN1 mRNA
Alitretinoin results in decreased expression of FN1 mRNA; Alitretinoin results in decreased expression of FN1 protein
CTD PMID:11139446 PMID:16648578 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Foxa1 forkhead box A1 increases expression ISO Alitretinoin results in increased expression of FOXA1 mRNA CTD PMID:17034753 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO Alitretinoin results in increased expression of G6PD mRNA CTD PMID:15982314 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression ISO Alitretinoin results in decreased expression of GAPDH protein CTD PMID:28886987 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gata6 GATA binding protein 6 increases expression ISO Alitretinoin results in increased expression of GATA6 mRNA CTD PMID:17034753 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
JBrowse link
G Gba glucosylceramidase beta decreases expression ISO Alitretinoin results in decreased expression of GBA mRNA CTD PMID:15982314 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Gck glucokinase decreases expression
decreases activity
ISO
EXP
Alitretinoin results in decreased expression of GCK mRNA
Alitretinoin results in decreased activity of GCK protein
CTD PMID:21115832 PMID:21670153 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Alitretinoin results in increased expression of GDF15 mRNA CTD PMID:15982314 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gdf2 growth differentiation factor 2 decreases expression ISO Alitretinoin results in decreased expression of GDF2 mRNA CTD PMID:15982314 NCBI chr16:9,255,430...9,261,429
Ensembl chr16:9,255,430...9,261,429
JBrowse link
G Gh1 growth hormone 1 increases expression
multiple interactions
EXP Alitretinoin results in increased expression of GH1 mRNA
Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]; Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]; Pentetic Acid promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA]]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]; Zinc inhibits the reaction [Pentetic Acid promotes the reaction [Triiodothyronine promotes the reaction [Alitretinoin results in increased expression of GH1 mRNA]]]
CTD PMID:10720163 PMID:15240998 PMID:17090972 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Ghrh growth hormone releasing hormone multiple interactions EXP Alitretinoin promotes the reaction [Dexamethasone results in increased expression of GHRH mRNA] CTD PMID:17090972 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
JBrowse link
G Glul glutamate-ammonia ligase increases expression ISO Alitretinoin results in increased expression of GLUL mRNA CTD PMID:15982314 NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Alitretinoin results in increased expression of GPX2 mRNA CTD PMID:15623509 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Grb7 growth factor receptor bound protein 7 decreases expression ISO Alitretinoin results in decreased expression of GRB7 mRNA CTD PMID:15982314 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression
EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]; [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased expression of GSTA2 mRNA; [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased expression of GSTA2 protein; [Pioglitazone co-treated with Alitretinoin] results in increased expression of GSTA2 protein; [Rosiglitazone co-treated with Alitretinoin] results in increased expression of GSTA2 protein; [Troglitazone co-treated with Alitretinoin] results in increased expression of GSTA2 protein
Alitretinoin results in increased expression of GSTA2 protein
CTD PMID:15150131 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO Alitretinoin results in decreased expression of GSTM1 mRNA CTD PMID:15982314 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H3f4 H3.4 histone multiple interactions ISO [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H3-4 protein] CTD PMID:15964820 NCBI chr10:43,740,797...43,741,207 JBrowse link
G H4f16 H4 histone 16 decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of H4F16 mRNA
[Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H4-16 protein modified form binds to TGM2 gene]; [Dimethyl Sulfoxide co-treated with Alitretinoin] results in increased methylation of H4-16 protein; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H4-16 protein]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased acetylation of H4-16 protein]]
CTD PMID:15964820 PMID:16392701
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Alitretinoin results in increased expression of HBEGF mRNA CTD PMID:15982314 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hgf hepatocyte growth factor decreases expression
decreases secretion
increases expression
increases secretion
ISO Alitretinoin results in decreased expression of HGF mRNA
Alitretinoin results in decreased secretion of HGF protein
Alitretinoin results in increased expression of HGF mRNA
Alitretinoin results in increased secretion of HGF protein
CTD PMID:11223164 PMID:16192631 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP Alitretinoin results in decreased expression of HNF4A mRNA CTD PMID:21115832 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 decreases expression ISO Alitretinoin results in decreased expression of HNRNPA2B1 protein CTD PMID:28886987 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hpgds hematopoietic prostaglandin D synthase increases expression EXP Alitretinoin results in increased expression of HPGDS mRNA CTD PMID:16648578 NCBI chr 4:94,368,426...94,397,931
Ensembl chr 4:94,373,342...94,397,883
JBrowse link
G Hps5 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 increases expression EXP Alitretinoin results in increased expression of SAA2 mRNA CTD PMID:16648578 NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:97,247,598...97,321,019
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Alitretinoin results in decreased expression of HSD11B1 mRNA CTD PMID:15982314 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases activity
increases expression
ISO Alitretinoin results in increased activity of HSD17B1 protein
Alitretinoin results in increased expression of HSD17B1 mRNA
CTD PMID:16513093 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 decreases expression EXP Alitretinoin results in decreased expression of HSPH1 mRNA CTD PMID:16648578 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion
decreases expression
ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]; [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]
Alitretinoin results in decreased secretion of IFNG protein
Alitretinoin results in decreased expression of IFNG mRNA; Alitretinoin results in decreased expression of IFNG protein
CTD PMID:11970994 PMID:17118196 PMID:21268089 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO Alitretinoin results in increased expression of IFNGR1 protein CTD PMID:16085646 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
increases expression
ISO Alitretinoin results in decreased expression of IGF1 protein
Alitretinoin results in increased expression of IGF1 mRNA
CTD PMID:15982314 PMID:15994153 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP Alitretinoin results in increased expression of IGFBP2 mRNA CTD PMID:16648578 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects binding
increases expression
ISO [Alitretinoin binds to RARB protein] which binds to IGFBP3 promoter
Alitretinoin results in increased expression of IGFBP3 mRNA; Alitretinoin results in increased expression of IGFBP3 protein
CTD PMID:15994153 PMID:16760641 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha decreases expression ISO Alitretinoin results in decreased expression of IL10RA mRNA CTD PMID:15982314 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Alitretinoin results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:17118196 PMID:17475839 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Alitretinoin results in decreased expression of [IL12A protein binds to IL12B protein]
Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]
CTD PMID:16303184 PMID:17118196 PMID:17475839 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 increases expression ISO Alitretinoin results in increased expression of IL13 mRNA; Alitretinoin results in increased expression of IL13 protein CTD PMID:17118196 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Alitretinoin results in increased expression of IL1B mRNA
CTD PMID:15968640 PMID:15982314 PMID:16303184 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO Alitretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]
Alitretinoin results in decreased expression of IL2 mRNA; Alitretinoin results in decreased expression of IL2 protein
CTD PMID:12421932 PMID:17118196 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il24 interleukin 24 decreases expression ISO Alitretinoin results in decreased expression of IL24 mRNA CTD PMID:15982314 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
increases secretion
ISO Alitretinoin results in increased expression of IL4 mRNA; Alitretinoin results in increased expression of IL4 protein
IL4 protein promotes the reaction [Alitretinoin results in increased secretion of IL4 protein]
CTD PMID:11970994 PMID:17118196 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 increases expression ISO Alitretinoin results in increased expression of IL5 mRNA; Alitretinoin results in increased expression of IL5 protein CTD PMID:17118196 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:15968640 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]
[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA; [[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased uptake of Oleic Acid; [Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] results in increased susceptibility to Alitretinoin; Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA]
CTD PMID:10777552 PMID:11348869 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insr insulin receptor increases phosphorylation EXP Alitretinoin results in increased phosphorylation of INSR protein CTD PMID:18063688 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO Alitretinoin results in increased expression of IRF1; Alitretinoin results in increased expression of IRF1 mRNA; Alitretinoin results in increased expression of IRF1 protein CTD PMID:16085646 PMID:16636311 PMID:17229644 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression ISO Alitretinoin results in increased expression of ITGA4 mRNA CTD PMID:15982314 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of ITGAM protein]; Vitamin D promotes the reaction [Alitretinoin results in increased expression of ITGAM protein] CTD PMID:15964820 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgax integrin subunit alpha X multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of ITGAX protein]; Vitamin D promotes the reaction [Alitretinoin results in increased expression of ITGAX protein] CTD PMID:15964820 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of ITGB2 protein] CTD PMID:15964820 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Ivl involucrin increases expression
decreases expression
ISO Alitretinoin results in increased expression of IVL mRNA
Alitretinoin results in decreased expression of IVL mRNA
CTD PMID:8853895 PMID:17034753 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Alitretinoin co-treated with Tretinoin co-treated with Calcitriol] results in increased expression of JUN protein; Alitretinoin inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:8950452 PMID:19812349 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Klk10 kallikrein related-peptidase 10 increases expression ISO Alitretinoin results in increased expression of KLK10 mRNA; Alitretinoin results in increased expression of KLK10 protein CTD PMID:16800735 NCBI chr 1:94,234,536...94,239,369
Ensembl chr 1:94,235,096...94,239,376
JBrowse link
G Krt1 keratin 1 decreases expression ISO Alitretinoin results in decreased expression of KRT1 mRNA CTD PMID:15982314 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 decreases expression ISO Alitretinoin results in decreased expression of KRT10 mRNA CTD PMID:15982314 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Krt14 keratin 14 decreases expression ISO Alitretinoin results in decreased expression of KRT14 mRNA CTD PMID:8853895 PMID:15982314 NCBI chr10:85,137,932...85,141,990
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt15 keratin 15 increases expression ISO Alitretinoin results in increased expression of KRT15 mRNA CTD PMID:15982314 NCBI chr10:85,066,797...85,070,614 JBrowse link
G Krt17 keratin 17 decreases expression ISO Alitretinoin results in decreased expression of KRT17 mRNA CTD PMID:15982314 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
JBrowse link
G Krt18 keratin 18 increases expression ISO Alitretinoin results in increased expression of KRT18 mRNA CTD PMID:17034753 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Krt19 keratin 19 increases expression ISO Alitretinoin results in increased expression of KRT19 mRNA; Alitretinoin results in increased expression of KRT19 protein CTD PMID:11214822 PMID:15982314 PMID:17034753 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Krt5 keratin 5 decreases expression ISO Alitretinoin results in decreased expression of KRT5 mRNA CTD PMID:8853895 PMID:15982314 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Krt6a keratin 6A decreases expression ISO Alitretinoin results in decreased expression of KRT6A mRNA CTD PMID:15982314 NCBI chr 7:132,829,278...132,833,665 JBrowse link
G Krt7 keratin 7 increases expression ISO Alitretinoin results in increased expression of KRT7 mRNA; Alitretinoin results in increased expression of KRT7 protein CTD PMID:15982314 PMID:17034753 NCBI chr 7:132,528,863...132,545,052
Ensembl chr 7:132,528,895...132,545,052
JBrowse link
G Krt75 keratin 75 decreases expression ISO Alitretinoin results in decreased expression of KRT75 mRNA CTD PMID:15982314 NCBI chr 7:132,687,101...132,697,360
Ensembl chr 7:132,688,237...132,697,345
JBrowse link
G Krt8 keratin 8 increases expression ISO Alitretinoin results in increased expression of KRT8 mRNA CTD PMID:17034753 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lama2 laminin subunit alpha 2 decreases expression ISO Alitretinoin results in decreased expression of LAMA2 mRNA CTD PMID:15982314 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Alitretinoin results in decreased expression of LAMA3 mRNA CTD PMID:15982314 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
JBrowse link
G Lamc3 laminin subunit gamma 3 increases expression ISO Alitretinoin results in increased expression of LAMC3 mRNA CTD PMID:15982314 NCBI chr 3:15,165,220...15,226,697
Ensembl chr 3:15,165,220...15,226,697
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Alitretinoin results in increased expression of LCN2 mRNA CTD PMID:15982314 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Lep leptin multiple interactions EXP [Alitretinoin co-treated with Clofibrate] results in increased expression of LEP protein CTD PMID:9751766 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases expression
ISO [Alitretinoin co-treated with 22-hydroxycholesterol] results in increased expression of LPL mRNA; [Alitretinoin co-treated with TO-901317] results in increased expression of LPL mRNA
Alitretinoin results in increased expression of LPL mRNA
CTD PMID:16142410 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lypla1 lysophospholipase 1 decreases expression EXP Alitretinoin results in decreased expression of LYPLA1 mRNA CTD PMID:16648578 NCBI chr 5:14,679,605...14,708,774
Ensembl chr 5:14,679,606...14,708,746
JBrowse link
G Map2 microtubule-associated protein 2 increases expression ISO Alitretinoin results in increased expression of MAP2 protein CTD PMID:23500671 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
Alitretinoin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of MAPK1 protein
CTD PMID:16043492 PMID:16611854 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of MAPK3 protein
Alitretinoin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
CTD PMID:16043492 PMID:16611854 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 increases expression EXP Alitretinoin results in increased expression of MARK1 mRNA CTD PMID:16648578 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173
JBrowse link
G Meis1 Meis homeobox 1 increases expression ISO Alitretinoin results in increased expression of MEIS1 mRNA CTD PMID:17034753 NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
JBrowse link
G Meis2 Meis homeobox 2 increases expression ISO Alitretinoin results in increased expression of MEIS2 mRNA CTD PMID:17034753 NCBI chr 3:102,742,905...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Meox1 mesenchyme homeobox 1 increases expression ISO Alitretinoin results in increased expression of MEOX1 mRNA CTD PMID:17034753 NCBI chr10:86,818,450...86,837,563
Ensembl chr10:86,818,478...86,837,660
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases phosphorylation ISO Alitretinoin results in increased phosphorylation of MET protein CTD PMID:16192631 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfap2 microfibril associated protein 2 decreases expression ISO Alitretinoin results in decreased expression of MFAP2 mRNA CTD PMID:15982314 NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259
JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Alitretinoin results in increased expression of MITF mRNA CTD PMID:23489423 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Alitretinoin results in decreased expression of MMP10 mRNA CTD PMID:15982314 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of MTOR protein CTD PMID:16611854 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO Alitretinoin results in increased expression of MTTP mRNA CTD PMID:15537571 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming increases expression ISO Alitretinoin results in increased expression of MUC5AC mRNA CTD PMID:17034753 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; [Alitretinoin co-treated with NCOA1 protein] results in increased activity of RXRB protein; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein] CTD PMID:17223708 PMID:22227104 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ndufaf3 NADH:ubiquinone oxidoreductase complex assembly factor 3 increases expression EXP Alitretinoin results in increased expression of NDUFAF3 mRNA CTD PMID:16648578 NCBI chr 8:109,261,362...109,263,194
Ensembl chr 8:109,261,363...109,263,194
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO Alitretinoin results in increased expression of NEDD9 mRNA CTD PMID:15982314 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nefh neurofilament heavy chain increases expression ISO Alitretinoin results in increased expression of NEFH protein CTD PMID:23500671 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nefl neurofilament light chain decreases expression ISO Alitretinoin results in decreased expression of NEFL mRNA CTD PMID:15982314 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nefm neurofilament medium chain increases expression ISO Alitretinoin results in increased expression of NEFM protein CTD PMID:8892963 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] results in increased activity of NFE2L2 protein CTD PMID:15150131 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nkx3-1 NK3 homeobox 1 increases expression ISO Alitretinoin results in increased expression of NKX3-1 mRNA; Alitretinoin results in increased expression of NKX3-1 protein CTD PMID:16763719 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 decreases expression ISO Alitretinoin results in decreased expression of NME2 protein CTD PMID:28886987 NCBI chr10:78,898,097...78,903,600
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Npm1 nucleophosmin 1 decreases expression ISO Alitretinoin results in decreased expression of NPM1 protein CTD PMID:28886987 NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO [Alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H2 protein CTD PMID:16888799 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO [Alitretinoin co-treated with 22-hydroxycholesterol] affects the localization of NR1H3 protein; Alitretinoin inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA] CTD PMID:16888799 PMID:21268089 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin binds to and results in increased activity of NR1I3 protein alternative form; Alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]
Alitretinoin results in increased activity of [RXRA protein binds to NR1I3 protein]
CTD PMID:17223708 PMID:19686701 PMID:31312845 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions
decreases expression
ISO Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA]
Alitretinoin results in decreased expression of NR5A2 mRNA
CTD PMID:16357189 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Nrl neural retina leucine zipper increases expression ISO Alitretinoin results in increased expression of NRL mRNA; Alitretinoin results in increased expression of NRL protein CTD PMID:16854989 NCBI chr15:29,008,104...29,009,832
Ensembl chr15:29,008,104...29,009,832
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases expression ISO Alitretinoin results in decreased expression of ODC1 mRNA CTD PMID:15982314 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Alitretinoin results in increased expression of OLR1 mRNA CTD PMID:17034753 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G P2rx2 purinergic receptor P2X 2 increases expression EXP Alitretinoin results in increased expression of P2RX2 mRNA; Alitretinoin results in increased expression of P2RX2 protein CTD PMID:16638968 NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891
JBrowse link
G Padi4 peptidyl arginine deiminase 4 multiple interactions
increases expression
ISO Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of PADI4 mRNA] CTD PMID:15964820 NCBI chr 5:153,041,351...153,074,412
Ensembl chr 5:153,041,352...153,074,362
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Alitretinoin results in increased cleavage of PARP1 protein CTD PMID:16449964 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions
EXP
ISO
Alitretinoin results in increased expression of PCK1 mRNA
[Tretinoin co-treated with Alitretinoin] affects the reaction [Vitamin A affects the expression of PCK1 mRNA]
CTD PMID:16317119 PMID:17320364 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Alitretinoin results in increased expression of PCSK2 mRNA CTD PMID:15585599 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]; Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein] CTD PMID:11348869 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 decreases expression ISO
EXP
Alitretinoin results in decreased expression of PDX1 mRNA CTD PMID:21115832 PMID:21670153 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Alitretinoin results in increased expression of PER1 mRNA CTD PMID:17069763 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pex19 peroxisomal biogenesis factor 19 decreases expression EXP Alitretinoin results in decreased expression of PEX19 mRNA CTD PMID:16648578 NCBI chr13:84,592,277...84,608,793
Ensembl chr13:84,592,312...84,608,608
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression ISO Alitretinoin results in increased expression of PIK3R1 mRNA; Alitretinoin results in increased expression of PIK3R1 protein CTD PMID:16288212 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 increases expression EXP Alitretinoin results in increased expression of PIK3R3 mRNA CTD PMID:16648578 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
JBrowse link
G Pir pirin increases expression ISO Alitretinoin results in increased expression of PIR mRNA CTD PMID:15982314 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO Alitretinoin results in decreased expression of PKM protein CTD PMID:28886987 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Alitretinoin results in increased expression of PLAT mRNA CTD PMID:15982314 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA CTD PMID:16292757 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
ISO
EXP
Alitretinoin results in increased activity of PPARG protein
[9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]; Alitretinoin binds to and results in increased activity of PPARG protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Alitretinoin results in increased activity of PPARG protein]; MG 262 promotes the reaction [Alitretinoin results in increased activity of PPARG protein]
[Pioglitazone co-treated with Alitretinoin] inhibits the reaction [PPARG protein results in increased susceptibility to Methamphetamine]; PPARG protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]
CTD PMID:15150131 PMID:15707588 PMID:16513826 PMID:17019405 PMID:18063688 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO Alitretinoin results in increased expression of PPARGC1A mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; PPARG protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; RXRA protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]
CTD PMID:16513826 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Prame PRAME nuclear receptor transcriptional regulator multiple interactions ISO Alitretinoin promotes the reaction [RARA protein binds to PRAME protein] CTD PMID:16179254 NCBI chr  X:98,567,994...98,574,654
Ensembl chr  X:98,569,415...98,572,096
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Alitretinoin results in decreased expression of PTGS1 mRNA CTD PMID:15982314 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Alitretinoin results in decreased expression of PTGS2 mRNA CTD PMID:15982314 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of PTHLH mRNA
Alitretinoin promotes the reaction [Calcitriol results in decreased expression of PTHLH mRNA]
CTD PMID:16243370 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression EXP Alitretinoin results in increased expression of RAB11B mRNA CTD PMID:16648578 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
JBrowse link
G Rab27a RAB27A, member RAS oncogene family decreases response to substance
decreases expression
ISO RAB27A gene mutant form results in decreased susceptibility to Alitretinoin
Alitretinoin results in decreased expression of RAB27A mRNA
CTD PMID:16449964 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Rara retinoic acid receptor, alpha increases expression
multiple interactions
decreases expression
EXP
ISO
Alitretinoin results in increased expression of RARA protein
[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]; CAMK4 protein promotes the reaction [Alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; Okadaic Acid promotes the reaction [Alitretinoin results in increased activity of RARA protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; trichostatin A promotes the reaction [Alitretinoin results in increased activity of RARA protein]
Alitretinoin results in decreased expression of RARA protein
Alitretinoin results in increased expression of RARA mRNA
Alitretinoin binds to and results in increased activity of RARA protein; Alitretinoin promotes the reaction [RARA protein binds to PRAME protein]; RARA protein promotes the reaction [Alitretinoin results in increased expression of ABCC6 mRNA]
CTD PMID:8892963 PMID:11139446 PMID:15375546 PMID:15773917 PMID:16043492 More... NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarb retinoic acid receptor, beta affects binding
multiple interactions
increases expression
ISO [Alitretinoin binds to RARB protein] which binds to IGFBP3 promoter
Alitretinoin binds to [RXRA protein binds to RARB protein]
[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA; sodium arsenite inhibits the reaction [[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]
Alitretinoin binds to and results in increased activity of RARB protein
Alitretinoin results in increased expression of RARB mRNA
Alitretinoin results in increased expression of RARB mRNA; Alitretinoin results in increased expression of RARB protein
CTD PMID:8892963 PMID:11139446 PMID:15159591 PMID:15375546 PMID:16413115 More... NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma decreases expression
increases activity
multiple interactions
decreases response to substance
ISO Alitretinoin results in decreased expression of RARG protein
Alitretinoin results in increased activity of RARG protein
Alitretinoin binds to and results in increased activity of RARG protein
RARG gene mutant form results in decreased susceptibility to Alitretinoin
CTD PMID:10748128 PMID:15375546 PMID:15615532 PMID:18180267 PMID:19812349 More... NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO Alitretinoin results in increased expression of RARRES1 mRNA CTD PMID:17034753 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
JBrowse link
G Rasl11a RAS-like family 11 member A increases expression EXP Alitretinoin results in increased expression of RASL11A mRNA CTD PMID:16648578 NCBI chr12:8,258,148...8,262,576
Ensembl chr12:8,258,159...8,262,576
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions
decreases phosphorylation
ISO Alitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]
Alitretinoin results in decreased phosphorylation of RB1 protein
CTD PMID:11348869 PMID:16273314 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbp1 retinol binding protein 1 increases abundance ISO RBP1 gene mutant form results in increased abundance of Alitretinoin CTD PMID:21670153 NCBI chr 8:99,025,218...99,046,740
Ensembl chr 8:99,025,206...99,046,743
JBrowse link
G Rbp2 retinol binding protein 2 increases expression EXP Alitretinoin results in increased expression of RBP2 mRNA CTD PMID:19409899 NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473
JBrowse link
G Rest RE1-silencing transcription factor increases expression EXP Alitretinoin results in increased expression of REST mRNA CTD PMID:16648578 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354
JBrowse link
G Retn resistin decreases expression
decreases secretion
ISO Alitretinoin results in decreased expression of RETN mRNA
Alitretinoin results in decreased secretion of RETN protein
CTD PMID:15047602 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO Alitretinoin results in decreased expression of RHOA mRNA CTD PMID:15982314 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B decreases expression ISO Alitretinoin results in decreased expression of RHOB mRNA CTD PMID:15982314 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Rnf5 ring finger protein 5 decreases expression ISO Alitretinoin results in decreased expression of RNF5 mRNA CTD PMID:15982314 NCBI chr20:4,145,539...4,147,985
Ensembl chr20:4,145,507...4,147,985
JBrowse link
G Rpl22 ribosomal protein L22 increases expression EXP Alitretinoin results in increased expression of RPL22 mRNA CTD PMID:16648578 NCBI chr 5:162,835,251...162,841,977
Ensembl chr 5:162,833,740...162,843,368
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of RPS6KA1 protein CTD PMID:16611854 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions
increases activity
affects binding
increases ubiquitination
increases expression
increases degradation
decreases expression
affects localization
increases localization
ISO
EXP
[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA; Alitretinoin binds to and results in increased activity of RXRA protein; Alitretinoin inhibits the reaction [TGIF1 protein binds to RXRA protein]; Alitretinoin inhibits the reaction [TGIF1 protein results in increased activity of RXRA protein]; Alitretinoin results in increased activity of [RXRA protein binds to NR1I3 protein]; Alitretinoin results in increased activity of [RXRA protein binds to RXRA protein]; ethyl(E,E,E)-7-(2-n-propoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-3-yl)-6-fluorp-3-methylocta-2,4,6-trienoate inhibits the reaction [Alitretinoin results in increased activity of [RXRA protein binds to RXRA protein]]; RXRA protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; sodium arsenite inhibits the reaction [[Alitretinoin co-treated with RXRA protein] results in increased expression of RARB mRNA]
Alitretinoin results in increased activity of RXRA protein
Alitretinoin binds to RXRA protein
Alitretinoin results in increased ubiquitination of RXRA protein
Alitretinoin binds to [RXRA protein binds to RARB protein]
Alitretinoin results in increased expression of RXRA protein
Alitretinoin binds to RXRA protein; RXRA protein binds to Alitretinoin
Alitretinoin results in increased degradation of RXRA protein
[9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]
Alitretinoin results in decreased expression of RXRA protein
1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; [Alitretinoin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; [Alitretinoin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] affects the localization of RXRA protein; [Alitretinoin co-treated with Calcitriol] results in increased stability of [RXRA protein binds to VDR protein]; [Alitretinoin co-treated with RXRA protein] results in increased expression of PSG5 mRNA; [Alitretinoin results in increased activity of RXRA protein] which binds to PSG5 promoter; [pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA; Alitretinoin analog binds to and results in increased activity of RXRA protein; Alitretinoin binds to and affects the activity of RXRA protein; Alitretinoin binds to and results in increased activity of RXRA protein; Alitretinoin inhibits the reaction [triphenyltin hydroxide binds to RXRA protein]; Alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Alitretinoin results in increased degradation of RXRA protein]; Flurbiprofen inhibits the reaction [Alitretinoin binds to RXRA protein]; RXRA promotes the reaction [Alitretinoin results in increased expression of APOA2 mRNA]; RXRA protein affects the reaction [Alitretinoin results in increased expression of CYP2B6 mRNA]; tributyltin inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyl bismuth inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenylarsine inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyltin chloride inhibits the reaction [Alitretinoin binds to RXRA protein]; triphenyltin hydroxide inhibits the reaction [Alitretinoin binds to RXRA protein]
Alitretinoin affects the localization of RXRA protein
Alitretinoin results in increased expression of RXRA mRNA
Alitretinoin results in increased localization of RXRA protein
CTD PMID:8668150 PMID:11139446 PMID:15150131 PMID:15159591 PMID:15375546 More... NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Rxrb retinoid X receptor beta increases degradation
affects binding
increases activity
increases expression
multiple interactions
ISO
EXP
Alitretinoin results in increased degradation of RXRB protein
Alitretinoin binds to RXRB protein
Alitretinoin results in increased activity of RXRB protein
Alitretinoin results in increased expression of RXRB protein
2,4,6-trichlorophenol inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]; [Alitretinoin co-treated with NCOA1 protein] results in increased activity of RXRB protein; Alitretinoin binds to and affects the activity of RXRB protein; Alitretinoin promotes the reaction [RXRB protein binds to BGLAP gene]; bisphenol A analog inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]; bisphenol A inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]; tetrachlorodian inhibits the reaction [Alitretinoin binds to and results in increased activity of RXRB protein]
CTD PMID:11939783 PMID:12898515 PMID:15941851 PMID:16043492 PMID:18207673 More... NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
G Rxrg retinoid X receptor gamma increases expression
multiple interactions
decreases expression
affects activity
affects binding
ISO Alitretinoin results in increased expression of RXRG mRNA
Alitretinoin binds to and affects the activity of RXRG protein
Alitretinoin results in decreased expression of RXRG mRNA
Alitretinoin affects the activity of RXRG protein
Alitretinoin binds to RXRG protein
CTD PMID:8892963 PMID:9092800 PMID:11139446 PMID:12114515 PMID:15941851 More... NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO Alitretinoin results in decreased expression of S100A1 mRNA CTD PMID:15982314 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression ISO Alitretinoin results in decreased expression of S100A8 mRNA CTD PMID:15982314 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Alitretinoin results in increased expression of S100A9 mRNA CTD PMID:15982314 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scarb1 scavenger receptor class B, member 1 increases expression ISO Alitretinoin results in increased expression of SCARB1 mRNA CTD PMID:16142410 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Alitretinoin results in increased expression of SCD mRNA CTD PMID:11397803 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sema6b semaphorin 6B multiple interactions ISO Alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B mRNA]; Alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B protein]; Alitretinoin promotes the reaction [Troglitazone results in decreased expression of SEMA6B mRNA]; Alitretinoin promotes the reaction [Troglitazone results in decreased expression of SEMA6B protein] CTD PMID:16525649 NCBI chr 9:950,939...967,905
Ensembl chr 9:950,939...961,521
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression ISO Alitretinoin results in increased expression of SERPINA3 mRNA CTD PMID:15982314 NCBI chr 6:123,323,632...123,331,166 JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO Alitretinoin results in decreased expression of SERPINB2 mRNA CTD PMID:15982314 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Serpinb8 serpin family B member 8 decreases expression ISO Alitretinoin results in decreased expression of SERPINB8 mRNA CTD PMID:15982314 NCBI chr13:23,626,945...23,650,270
Ensembl chr13:23,626,945...23,650,835
JBrowse link
G Serpinb9 serpin family B member 9 decreases expression ISO Alitretinoin results in decreased expression of SERPINB9 mRNA CTD PMID:15982314 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Alitretinoin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] CTD PMID:16192631 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression ISO Alitretinoin results in decreased expression of SLC16A1 mRNA CTD PMID:15982314 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions
increases expression
ISO
EXP
[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA; Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with Alitretinoin] results in increased expression of SLC27A1 mRNA]
Alitretinoin results in increased expression of SLC27A1 mRNA
Dactinomycin inhibits the reaction [Alitretinoin results in increased expression of SLC27A1 mRNA]
CTD PMID:10777552 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
JBrowse link
G Slc2a2 solute carrier family 2 member 2 decreases activity
decreases expression
EXP
ISO
Alitretinoin results in decreased activity of SLC2A2 protein
Alitretinoin results in decreased expression of SLC2A2 mRNA
CTD PMID:21115832 PMID:21670153 NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression EXP Alitretinoin results in increased expression of SLC2A4 mRNA; Alitretinoin results in increased expression of SLC2A4 protein CTD PMID:16273324 PMID:18063688 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression ISO Alitretinoin results in increased expression of SLC5A5 mRNA CTD PMID:16954431 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [TO-901317 co-treated with Alitretinoin] results in increased expression of SMAD3 protein CTD PMID:17194744 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Snn stannin decreases expression EXP Alitretinoin results in decreased expression of SNN mRNA CTD PMID:16648578 NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021
JBrowse link
G Socs1 suppressor of cytokine signaling 1 decreases expression ISO Alitretinoin results in decreased expression of SOCS1 mRNA CTD PMID:15982314 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs2 suppressor of cytokine signaling 2 increases expression ISO Alitretinoin results in increased expression of SOCS2 mRNA CTD PMID:15982314 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 increases expression EXP Alitretinoin results in increased expression of SPINK1 mRNA CTD PMID:16648578 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression
increases expression
ISO Alitretinoin results in decreased expression of SPP1 mRNA
Alitretinoin results in increased expression of SPP1 mRNA
Alitretinoin results in decreased expression of SPP1 mRNA; Alitretinoin results in decreased expression of SPP1 protein
CTD PMID:11139446 PMID:16392701 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Sprr1b small proline-rich protein 1B decreases expression ISO Alitretinoin results in decreased expression of SPRR1B mRNA CTD PMID:15982314 NCBI chr 2:178,009,130...178,009,567
Ensembl chr 2:178,009,130...178,009,567
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [Arsenic Trioxide results in decreased expression of SREBF1 protein] CTD PMID:27622732 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]; [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein]; Alitretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein CTD PMID:16085646 PMID:21268089 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Sts steroid sulfatase increases activity ISO Alitretinoin results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression ISO Alitretinoin results in decreased expression of SULT2A1 mRNA CTD PMID:15982314 NCBI chr 1:75,451,178...75,508,142 JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 increases expression ISO Alitretinoin results in increased expression of TACSTD2 mRNA CTD PMID:15982314 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 increases phosphorylation
multiple interactions
EXP Alitretinoin results in increased phosphorylation of TBC1D4 protein
Oligomycins promotes the reaction [Alitretinoin results in increased phosphorylation of TBC1D4 protein]
CTD PMID:18063688 NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO Alitretinoin results in decreased expression of TERT mRNA CTD PMID:16180984 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases response to substance
decreases activity
decreases expression
ISO Alitretinoin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]
Alitretinoin results in decreased susceptibility to TGFB1 protein
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [Alitretinoin results in decreased expression of TGFB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA]
Alitretinoin results in decreased activity of TGFB1 protein
CTD PMID:16192631 PMID:16611854 PMID:21152098 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 increases expression ISO Alitretinoin results in increased expression of TGFB1I1 mRNA CTD PMID:15982314 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080
JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 increases expression
multiple interactions
ISO Alitretinoin results in increased expression of TGIF1 protein
Alitretinoin inhibits the reaction [TGIF1 protein binds to RXRA protein]; Alitretinoin inhibits the reaction [TGIF1 protein results in increased activity of RXRA protein]
CTD PMID:16192631 PMID:16428452 NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
JBrowse link
G Tgm1 transglutaminase 1 decreases expression ISO Alitretinoin results in decreased expression of TGM1 mRNA CTD PMID:8853895 PMID:15982314 NCBI chr15:29,191,039...29,206,000
Ensembl chr15:29,191,041...29,204,523
JBrowse link
G Tgm2 transglutaminase 2 multiple interactions
increases expression
increases activity
ISO [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H3-4 protein modified form binds to TGM2 gene]; [Alitretinoin co-treated with Dimethyl Sulfoxide] promotes the reaction [H4-16 protein modified form binds to TGM2 gene]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]; Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 protein]; periodate-oxidized adenosine inhibits the reaction [Alitretinoin results in increased expression of TGM2 mRNA]; periodate-oxidized adenosine inhibits the reaction [Dimethyl Sulfoxide promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]]; Vitamin D promotes the reaction [Alitretinoin results in increased expression of TGM2 mRNA]
Alitretinoin results in increased expression of TGM2 mRNA; Alitretinoin results in increased expression of TGM2 protein
Alitretinoin results in increased activity of TGM2 protein
CTD PMID:9516142 PMID:15964820 PMID:16158052 PMID:17034753 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO Alitretinoin results in decreased expression of THBS1 mRNA CTD PMID:15982314 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO [Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Alitretinoin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Alitretinoin results in decreased expression of TNF mRNA; Alitretinoin results in decreased expression of TNF protein
Alitretinoin inhibits the reaction [TNF protein results in increased expression of CYP4F11 mRNA]; Alitretinoin inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]
CTD PMID:15968640 PMID:16303184 PMID:17118196 PMID:19812349 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Alitretinoin results in increased expression of TNFRSF10A mRNA CTD PMID:16449964 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Alitretinoin results in increased expression of TNFSF10 mRNA; Alitretinoin results in increased expression of TNFSF10 protein CTD PMID:16449964 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tshb thyroid stimulating hormone subunit beta decreases expression ISO Alitretinoin results in decreased expression of TSHB mRNA; Alitretinoin results in decreased expression of TSHB protein CTD PMID:9092800 PMID:16306084 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Ttr transthyretin decreases expression EXP Alitretinoin results in decreased expression of TTR mRNA CTD PMID:16648578 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP Alitretinoin results in increased expression of TUBA1A mRNA CTD PMID:16648578 NCBI chr 7:130,113,214...130,116,880 JBrowse link
G Tyr tyrosinase increases expression ISO Alitretinoin results in increased expression of TYR mRNA; Alitretinoin results in increased expression of TYR protein CTD PMID:23489423 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions
EXP
ISO
Alitretinoin results in increased expression of UCP1 mRNA
2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole inhibits the reaction [Alitretinoin results in increased expression of UCP1 mRNA]; Glutathione inhibits the reaction [Alitretinoin results in increased expression of UCP1 mRNA]
CTD PMID:10600643 PMID:12414803 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase multiple interactions ISO [pirinixic acid co-treated with Alitretinoin co-treated with PPARA protein co-treated with RXRA protein] results in decreased expression of UGDH mRNA CTD PMID:16292757 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Alitretinoin results in increased expression of UGT1A1 mRNA CTD PMID:14620509 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression EXP Alitretinoin results in increased expression of UGT1A2 mRNA CTD PMID:14620509 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP Alitretinoin results in increased expression of UGT1A5 mRNA CTD PMID:14620509 NCBI chr 9:88,780,328...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP Alitretinoin results in decreased expression of UGT1A6 mRNA CTD PMID:14620509 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B decreases expression EXP Alitretinoin results in decreased expression of UGT2B mRNA CTD PMID:16648578 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link
G Uvrag UV radiation resistance associated decreases expression ISO Alitretinoin results in decreased expression of UVRAG mRNA CTD PMID:15982314 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
JBrowse link
G Vdr vitamin D receptor multiple interactions
affects activity
increases degradation
ISO [Alitretinoin co-treated with Calcitriol] results in increased stability of [RXRA protein binds to VDR protein]; Alitretinoin promotes the reaction [VDR protein binds to BGLAP gene]
Alitretinoin affects the activity of VDR protein
Alitretinoin results in increased degradation of VDR protein
CTD PMID:12898515 PMID:16204233 PMID:16936639 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Alitretinoin results in increased expression of VEGFA mRNA CTD PMID:16386082 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Alitretinoin results in decreased expression of VEGFC mRNA CTD PMID:15982314 NCBI chr16:37,712,408...37,827,657
Ensembl chr16:37,712,262...37,827,848
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO Alitretinoin results in decreased expression of VIM mRNA; Alitretinoin results in decreased expression of VIM protein
[Tretinoin co-treated with Alitretinoin] results in decreased expression of VIM mRNA; Tretinoin promotes the reaction [Alitretinoin results in decreased expression of VIM protein]
CTD PMID:28886987 PMID:31634547 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 multiple interactions ISO Alitretinoin inhibits the reaction [GW 4064 results in increased expression of VIPR1] CTD PMID:16037943 NCBI chr 8:121,303,739...121,339,587 JBrowse link
G Wnt5b Wnt family member 5B decreases expression ISO Alitretinoin results in decreased expression of WNT5B mRNA CTD PMID:15972578 NCBI chr 4:152,609,566...152,733,790
Ensembl chr 4:152,609,569...152,733,407
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            9-cis-retinoic acid 299
              9-cis-4-hydroxyretinoic acid 0
              9-cis-4-oxoretinoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        monocarboxylic acid 17636
                                          alpha,beta-unsaturated monocarboxylic acid 12219
                                            retinoic acid 7680
                                              9-cis-retinoic acid 299
                                                9-cis-4-hydroxyretinoic acid 0
                                                9-cis-4-oxoretinoic acid 0
paths to the root