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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nitric oxide donor
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Accession:CHEBI:50566 term browser browse the term
Definition:An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide.
Synonyms:related_synonym: NO donor;   NO donors;   NO generator;   NO generators;   NO releasing agent;   NO releasing agents;   nitric oxide donors;   nitric oxide generators;   nitric oxide releasing agent;   nitric oxide releasing agents
 alt_id: CHEBI:77704



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nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions
increases activity
affects expression
EXP Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]
Nitroglycerin affects the expression of PRKG1 mRNA; Nitroglycerin affects the expression of PRKG1 protein
CTD PMID:18037907 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 1203
    role 1146
      chemical role 766
        donor 494
          nitric oxide donor 4
            1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane 0
            1,1-diethyl-2-hydroxy-3-oxotriazane 0
            4-phenyl-3-furoxancarbonitrile 0
            NOC-5 0
            S-nitroso-N-acetyl-D-penicillamine 0
            S-nitrosoglutathione 3
            diethylamine NONOate 0
            hydroxylamine + 0
            isosorbide dinitrate 0
            isosorbide mononitrate 0
            molsidomine 0
            naproxcinod 0
            nitroglycerin 1
            sodium nitroprusside + 0
            sodium nitroprusside dihydrate 0
paths to the root