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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vasoconstrictor agent
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Accession:CHEBI:50514 term browser browse the term
Definition:Drug used to cause constriction of the blood vessels.

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(-)-ephedrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 multiple interactions ISO [Ephedrine co-treated with Caffeine] results in increased expression of APOA1 protein CTD PMID:16324916 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875 		JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions ISO [Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein CTD PMID:16324916 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Ephedrine co-treated with Caffeine] results in decreased expression of APOB protein CTD PMID:16324916 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997 		JBrowse link
G Apoc1 apolipoprotein C1 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein CTD PMID:16324916 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921 		JBrowse link
G Apoc2 apolipoprotein C2 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein CTD PMID:16324916 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136 		JBrowse link
G Apoc3 apolipoprotein C3 multiple interactions ISO [Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC3 protein CTD PMID:16324916 NCBI chr 8:50,529,318...50,531,498
Ensembl chr 8:50,529,318...50,531,498 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Caffeine co-treated with Ephedrine] results in increased cleavage of CASP3 protein CTD PMID:15537744 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cfd complement factor D multiple interactions ISO [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD mRNA]; [Caffeine co-treated with Ephedrine] affects the reaction [Sodium Glutamate results in decreased expression of CFD protein] CTD PMID:2307116 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ephedrine results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G H2ax H2A.X variant histone multiple interactions EXP [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein CTD PMID:15537744 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases export		 EXP [Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide; [verlukast results in decreased activity of ABCC1 protein] which promotes the reaction and affects the abundance of Epinephrine metabolite
ABCC1 protein results in increased export of Epinephrine metabolite		 CTD PMID:19053318 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Aco2 aconitase 2 increases expression EXP Epinephrine results in increased expression of ACO2 protein CTD PMID:19464573 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Actn1 actinin, alpha 1 increases expression EXP Epinephrine results in increased expression of ACTN1 protein CTD PMID:19464573 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555 		JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
increases activity
affects binding		 EXP
ISO		 [Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased transport of Calcium; Epinephrine binds to and results in increased activity of ADRA1A protein
Epinephrine results in increased activity of ADRA1A protein
[Epinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1A protein; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1A protein] which results in increased abundance of Calcium]
Epinephrine binds to ADRA1A protein		 CTD PMID:8183249 PMID:15306222 PMID:15672411 PMID:20030735 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases activity		 ISO [Epinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1B protein; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1B protein] which results in increased abundance of Calcium] CTD PMID:15306222 PMID:20030735 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
increases activity
multiple interactions		 ISO Epinephrine binds to ADRA1D protein
Epinephrine results in increased activity of ADRA1D protein
[Epinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; [Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Carvedilol inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]; Epinephrine binds to and results in increased activity of ADRA1D protein; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Phentolamine inhibits the reaction [[Epinephrine results in increased activity of ADRA1D protein] which results in increased abundance of Calcium]		 CTD PMID:8183249 PMID:15306222 PMID:20030735 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566 		JBrowse link
G Adra2a adrenoceptor alpha 2A increases activity
multiple interactions		 EXP
ISO		 Epinephrine results in increased activity of ADRA2A protein
Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein]; Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein]
[Epinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2A protein; Epinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]		 CTD PMID:17341653 PMID:17680988 PMID:20030735 PMID:30737458 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2B protein; Epinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:17680988 PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987 		JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions ISO [Epinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine binds to and results in increased activity of ADRA2C protein; Epinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan] CTD PMID:17680988 PMID:20030735 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP		 [CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Epinephrine
Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]
[Epinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB1 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Epinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]		 CTD PMID:8096834 PMID:12010770 PMID:14730417 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects response to substance
increases activity		 ISO
EXP		 [Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Atenolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Atenolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; carvedilol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Epinephrine binds to and results in increased activity of ADRB2 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein]; Epinephrine results in increased phosphorylation of and results in increased localization of ADRB2 protein; ICI 118551 inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; ICI 118551 inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]; Propranolol inhibits the reaction [[Epinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP]; Propranolol inhibits the reaction [Epinephrine binds to and results in increased activity of ADRB2 protein]
[Epinephrine results in increased activity of ADRB2 protein] which results in increased secretion of Histamine
ADRB2 affects the susceptibility to Epinephrine		 CTD PMID:1389726 PMID:11164953 PMID:12920204 PMID:14722251 PMID:14730417 PMID:16026475 PMID:16225854 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP
ISO		 Epinephrine binds to and results in increased activity of ADRB3 protein
[Epinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Epinephrine binds to and results in increased activity of ADRB3 protein; Epinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]		 CTD PMID:1682311 PMID:7815362 PMID:14730417 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Ak2 adenylate kinase 2 decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of AK2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein		 CTD PMID:19464573 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein CTD PMID:32305330 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aoc1 amine oxidase, copper containing 1 multiple interactions
increases activity		 EXP Cycloheximide inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Timolol inhibits the reaction [Epinephrine results in increased activity of AOC1 protein] CTD PMID:2860926 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584 		JBrowse link
G Aqp7 aquaporin 7 affects localization
multiple interactions
increases expression		 ISO Epinephrine affects the localization of AQP7 protein
INS1 inhibits the reaction [Epinephrine results in increased expression of AQP7 mRNA]		 CTD PMID:10777495 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP Epinephrine results in increased expression of ATP5F1A protein CTD PMID:19464573 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495 		JBrowse link
G Bmp2 bone morphogenetic protein 2 decreases expression ISO Epinephrine results in decreased expression of BMP2 mRNA; Epinephrine results in decreased expression of BMP2 protein CTD PMID:31520687 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G C1qbp complement C1q binding protein multiple interactions
increases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein
Epinephrine results in increased expression of C1QBP protein		 CTD PMID:19464573 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527 		JBrowse link
G Caly calcyon neuron-specific vesicular protein decreases secretion ISO CALY protein results in decreased secretion of Epinephrine CTD PMID:30753204 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Epinephrine results in increased expression of CA2 mRNA CTD PMID:12729923 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 Atenolol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]; carvedilol inhibits the reaction [Epinephrine results in increased activity of CASP3 protein]
Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein]		 CTD PMID:10728402 PMID:19135123 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase decreases response to substance ISO CAT results in decreased susceptibility to Epinephrine CTD PMID:25172298 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]; Propranolol inhibits the reaction [Epinephrine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL3 protein]]
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Epinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]		 CTD PMID:9863660 PMID:12538206 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; 2-methoxyidazoxan inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]
Epinephrine results in increased expression of CCND1 mRNA; Epinephrine results in increased expression of CCND1 protein
ADRA2A promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased expression of CCND1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased expression of CCND1 protein]		 CTD PMID:17680988 PMID:26964897 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Epinephrine results in decreased expression of CEBPB protein CTD PMID:31520687 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO [methyllycaconitine binds to and results in decreased activity of CHRNA7 protein] inhibits the reaction [Nicotine results in increased abundance of Epinephrine] CTD PMID:17498763 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196 		JBrowse link
G Comt catechol-O-methyltransferase increases methylation
multiple interactions		 ISO
EXP		 COMT protein results in increased methylation of Epinephrine
[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
[tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine		 CTD PMID:8821542 PMID:10064789 PMID:11160877 PMID:11248589 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO
EXP		 ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Dietary Fats promotes the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; Epinephrine promotes the reaction [Dietary Fats results in increased phosphorylation of CREB1 protein]; Ketoconazole inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]		 CTD PMID:17680988 PMID:22496244 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases abundance		 EXP corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Epinephrine]
CRH results in increased abundance of Epinephrine		 CTD PMID:1320258 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]; Isoproterenol inhibits the reaction [CSK protein promotes the reaction [Epinephrine results in increased abundance of Cyclic AMP]] CTD PMID:1699227 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303 		JBrowse link
G Ctnnb1 catenin beta 1 increases phosphorylation
multiple interactions		 EXP Epinephrine results in increased phosphorylation of CTNNB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]		 CTD PMID:26964897 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctsk cathepsin K increases expression ISO Epinephrine results in increased expression of CTSK mRNA CTD PMID:12729923 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions
increases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein
Epinephrine results in increased expression of CYCS protein		 CTD PMID:19464573 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance ISO DBH gene polymorphism affects the abundance of Epinephrine CTD PMID:16163519 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Des desmin multiple interactions
decreases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein
Epinephrine results in decreased expression of DES protein		 CTD PMID:19464573 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein CTD PMID:19464573 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832 		JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein CTD PMID:19464573 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
Ensembl chr 1:212,570,195...212,579,057 		JBrowse link
G Epha4 Eph receptor A4 increases phosphorylation ISO Epinephrine results in increased phosphorylation of EPHA4 protein CTD PMID:22273509 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein CTD PMID:19464573 NCBI chr 1:98,472,776...98,486,940
Ensembl chr 1:98,472,745...98,486,976 		JBrowse link
G Fabp3 fatty acid binding protein 3 affects expression
multiple interactions		 EXP Epinephrine affects the expression of FABP3 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein		 CTD PMID:19464573 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FAS protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FAS protein] CTD PMID:10728402 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO Atenolol inhibits the reaction [Epinephrine results in increased expression of FASLG protein]; carvedilol inhibits the reaction [Epinephrine results in increased expression of FASLG protein] CTD PMID:10728402 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fh fumarate hydratase increases expression EXP Epinephrine results in increased expression of FH protein CTD PMID:19464573 NCBI chr13:93,651,486...93,677,371
Ensembl chr13:93,651,484...93,677,377 		JBrowse link
G Foxo1 forkhead box O1 decreases expression ISO Epinephrine results in decreased expression of FOXO1 protein CTD PMID:31520687 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Gnb2 G protein subunit beta 2 multiple interactions ISO Epinephrine promotes the reaction [GNB2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr12:22,229,079...22,234,096
Ensembl chr12:22,229,079...22,234,096 		JBrowse link
G Gnb4 G protein subunit beta 4 multiple interactions ISO Epinephrine promotes the reaction [GNB4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 2:118,978,965...119,007,877
Ensembl chr 2:118,978,973...119,007,835 		JBrowse link
G Gng12 G protein subunit gamma 12 multiple interactions ISO Epinephrine promotes the reaction [GNG12 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 4:97,634,925...97,763,478
Ensembl chr 4:97,657,671...97,760,102 		JBrowse link
G Gng2 G protein subunit gamma 2 multiple interactions ISO Epinephrine promotes the reaction [GNG2 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr15:4,748,242...4,853,555
Ensembl chr15:4,850,122...4,853,555 		JBrowse link
G Gng3 G protein subunit gamma 3 multiple interactions ISO Epinephrine promotes the reaction [GNG3 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr 1:225,033,921...225,035,687
Ensembl chr 1:225,033,921...225,035,687 		JBrowse link
G Gng4 G protein subunit gamma 4 multiple interactions ISO Epinephrine promotes the reaction [GNG4 protein binds to ADRA2A protein] CTD PMID:30737458 NCBI chr17:90,266,571...90,316,278
Ensembl chr17:90,266,794...90,315,492 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions ISO Epinephrine promotes the reaction [GRK2 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 multiple interactions ISO Epinephrine promotes the reaction [GRK5 protein results in increased phosphorylation of ADRB2 protein] CTD PMID:14722251 NCBI chr 1:282,265,371...282,467,842
Ensembl chr 1:282,265,370...282,462,605 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein CTD PMID:19464573 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067 		JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects localization		 EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]
Epinephrine affects the localization of HSF1 protein		 CTD PMID:19135123 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein CTD PMID:19464573 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein CTD PMID:19464573 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Epinephrine results in increased expression of HSPA8 protein CTD PMID:19464573 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein CTD PMID:19464573 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of HSPB6 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein		 CTD PMID:19464573 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of IDH2 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein		 CTD PMID:19464573 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Epinephrine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:10588509 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:10588509 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions		 EXP
ISO		 Epinephrine results in decreased expression of IL6 mRNA
Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]		 CTD PMID:10588509 PMID:12423672 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression		 ISO [Epinephrine co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein]; Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] CTD PMID:1218171 PMID:6018752 PMID:6314140 PMID:32305330 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine] CTD PMID:16214444 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961 		JBrowse link
G Itgav integrin subunit alpha V increases expression ISO Epinephrine results in increased expression of ITGAV mRNA CTD PMID:12729923 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411 		JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance EXP ITGB1 results in increased susceptibility to Epinephrine CTD PMID:14984413 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases expression
affects localization
increases activity		 ISO
EXP		 Theophylline inhibits the reaction [Epinephrine results in increased activity of LIPE protein]
Epinephrine results in increased expression of LIPE mRNA
Epinephrine affects the localization of LIPE protein		 CTD PMID:7155675 PMID:10777495 PMID:11160373 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
affects activity		 ISO
EXP		 ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK1 protein]
Epinephrine deficiency results in increased activity of MAPK1 protein
Epinephrine affects the activity of MAPK1 protein		 CTD PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
affects activity		 ISO
EXP		 ADRA2A promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2B promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; ADRA2C promotes the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]; Epinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Epinephrine results in increased phosphorylation of MAPK3 protein]
Epinephrine deficiency results in increased activity of MAPK3 protein
Epinephrine affects the activity of MAPK3 protein		 CTD PMID:11093795 PMID:15292328 PMID:17680988 PMID:22496244 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO Epinephrine results in decreased expression of MEIS1 protein CTD PMID:31520687 NCBI chr14:103,182,178...103,321,809
Ensembl chr14:103,181,281...103,321,270 		JBrowse link
G Myl2 myosin light chain 2 multiple interactions
affects expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein
Epinephrine affects the expression of MYL2 protein		 CTD PMID:19464573 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Epinephrine affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 Atenolol inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Epinephrine results in increased expression of NOS2 mRNA		 CTD PMID:16925470 PMID:19439816 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Epinephrine results in increased expression of NTF3 mRNA; Epinephrine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886 		JBrowse link
G P2rx7 purinergic receptor P2X 7 decreases activity ISO Epinephrine results in decreased activity of P2RX7 protein CTD PMID:15459114 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042 		JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Epinephrine inhibits the reaction [P2RY12 gene mutant form results in decreased susceptibility to Adenosine Diphosphate] CTD PMID:11413167 NCBI chr 2:149,440,807...149,482,592
Ensembl chr 2:149,441,598...149,444,548 		JBrowse link
G Phb prohibitin multiple interactions
increases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein
Epinephrine results in increased expression of PHB protein		 CTD PMID:19464573 NCBI chr10:83,476,107...83,488,878
Ensembl chr10:83,476,107...83,488,878 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Epinephrine results in increased expression of PHGDH mRNA CTD PMID:12423672 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein CTD PMID:19464573 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Epinephrine results in increased expression of PPARGC1A mRNA CTD PMID:22496244 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression
multiple interactions		 EXP Epinephrine results in decreased expression of PPP2R1A protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein		 CTD PMID:19464573 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions
decreases expression		 EXP [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein
Epinephrine results in decreased expression of PRDX6 protein		 CTD PMID:19464573 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127 		JBrowse link
G Prkce protein kinase C, epsilon affects response to substance ISO
EXP		 PRKCE protein affects the susceptibility to Epinephrine CTD PMID:11454025 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Epinephrine results in decreased expression of PTGS2 mRNA; Epinephrine results in decreased expression of PTGS2 protein CTD PMID:31520687 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein] CTD PMID:19135123 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Ren renin multiple interactions
increases activity		 ISO ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein] CTD PMID:6314140 PMID:8592096 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151 		JBrowse link
G Sct secretin multiple interactions EXP Epinephrine inhibits the reaction [SCT protein results in increased abundance of Cyclic AMP] CTD PMID:6312992 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Epinephrine results in increased expression of SERPINE1 mRNA CTD PMID:15850565 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases uptake		 EXP
ISO		 [Corticosterone results in decreased activity of SLC22A3 protein] inhibits the reaction [Epinephrine results in increased abundance of Epinephrine metabolite]; [Corticosterone results in decreased activity of SLC22A3 protein] which results in decreased abundance of Epinephrine
SLC22A3 protein results in increased uptake of Epinephrine		 CTD PMID:19053318 PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Epinephrine CTD PMID:20858707 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects binding
increases expression
increases activity		 ISO
EXP		 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD1 protein]
Epinephrine binds to SOD1 protein mutant form
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 protein
Epinephrine results in increased expression of SOD1 mRNA; Epinephrine results in increased expression of SOD1 protein		 CTD PMID:11163531 PMID:19464573 PMID:23612299 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
increases activity		 ISO
EXP		 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Atenolol inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]; Vitamin E inhibits the reaction [Epinephrine results in increased activity of SOD2 protein]
[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 protein
Epinephrine results in increased expression of SOD2 mRNA; Epinephrine results in increased expression of SOD2 protein		 CTD PMID:11163531 PMID:19464573 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP Epinephrine results in increased expression of SUCLG2 protein CTD PMID:19464573 NCBI chr 4:127,552,100...127,824,970
Ensembl chr 4:127,552,101...127,824,970 		JBrowse link
G Th tyrosine hydroxylase increases chemical synthesis
multiple interactions		 ISO
EXP		 TH protein results in increased chemical synthesis of Epinephrine
[Clonidine results in increased expression of TH protein] which results in increased abundance of Epinephrine		 CTD PMID:9822156 PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
decreases expression		 ISO Propranolol inhibits the reaction [Epinephrine results in decreased expression of THY1] CTD PMID:7558147 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases secretion		 ISO
EXP		 Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Epinephrine results in decreased expression of TNF mRNA
Epinephrine results in decreased secretion of TNF protein		 CTD PMID:10588509 PMID:12423672 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions		 EXP Epinephrine results in increased expression of VDAC1 protein
[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein		 CTD PMID:19464573 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826 		JBrowse link
G Wnt4 Wnt family member 4 decreases expression ISO Epinephrine results in decreased expression of WNT4 mRNA; Epinephrine results in decreased expression of WNT4 protein CTD PMID:31520687 NCBI chr 5:155,649,238...155,668,065
Ensembl chr 5:155,649,217...155,672,579 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP [Epinephrine co-treated with Xanthine co-treated with XDH] affects the expression of MYL2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of AK2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DES protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of DLAT protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ECHS1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of ETFB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of FABP3 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSP90AB1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPA9 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HSPB6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PKM protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PPP2R1A protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of PRDX6 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of SOD2 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of C1QBP protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of CYCS protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 protein; [Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of VDAC1 protein; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] affects the localization of HSF1 protein]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]]; Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of CASP3 protein] CTD PMID:19135123 PMID:19464573 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta1 actin, alpha 1, skeletal muscle increases expression EXP Norepinephrine results in increased expression of ACTA1 mRNA CTD PMID:17592507 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084 		JBrowse link
G Ada adenosine deaminase multiple interactions
decreases response to substance		 ISO
EXP		 [ADA protein co-treated with Norepinephrine] results in increased secretion of Glycerol
Propranolol promotes the reaction [ADA protein results in decreased susceptibility to Norepinephrine]		 CTD PMID:7949234 PMID:17428236 NCBI chr 3:160,115,840...160,139,947
Ensembl chr 3:160,115,842...160,139,947 		JBrowse link
G Adra1a adrenoceptor alpha 1A affects binding
multiple interactions
increases activity
affects expression
affects response to substance		 ISO
EXP		 Norepinephrine binds to ADRA1A protein
[Norepinephrine binds to and results in increased activity of ADRA1A protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1A protein; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]
Norepinephrine results in increased activity of ADRA1A protein
5-methylurapidil inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; [chlorethylclonidine co-treated with Phenoxybenzamine] inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; BMY 7378 inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; chlorethylclonidine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Phenoxybenzamine inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]; Spiperone inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]
Norepinephrine affects the expression of ADRA1A protein
ADRA1A protein affects the susceptibility to Norepinephrine		 CTD PMID:8183249 PMID:10416824 PMID:12417256 PMID:20030735 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451 		JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO [Norepinephrine binds to and results in increased activity of ADRA1B protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1B protein; Norepinephrine inhibits the reaction [ADRA1B protein binds to Prazosin] CTD PMID:20030735 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Adra1d adrenoceptor alpha 1D affects binding
multiple interactions
affects response to substance		 ISO
EXP		 Norepinephrine binds to ADRA1D protein
[Norepinephrine binds to and results in increased activity of ADRA1D protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA1D protein; Norepinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]
ADRA1D affects the susceptibility to Norepinephrine
Norepinephrine binds to and affects the activity of ADRA1D protein		 CTD PMID:8183249 PMID:9639061 PMID:11901185 PMID:15493479 PMID:20030735 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566 		JBrowse link
G Adra2a adrenoceptor alpha 2A affects secretion
multiple interactions
affects abundance
affects binding		 EXP
ISO		 ADRA2A protein affects the secretion of Norepinephrine
[ADRA2A protein mutant form co-treated with ADRA2C protein mutant form] results in increased abundance of Norepinephrine
ADRA2A protein affects the abundance of Norepinephrine
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; [Norepinephrine binds to and results in increased activity of ADRA2A protein] which results in increased abundance of Calcium; Brimonidine Tartrate inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Dexmedetomidine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Doxazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Norepinephrine binds to and results in increased activity of ADRA2A protein; Norepinephrine inhibits the reaction [ADRA2A protein binds to 2-methoxyidazoxan]; Prazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; talipexole inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Yohimbine inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]
Norepinephrine binds to ADRA2A protein
[BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]]		 CTD PMID:10336518 PMID:10742289 PMID:11312645 PMID:20030735 PMID:20083574 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081 		JBrowse link
G Adra2b adrenoceptor alpha 2B multiple interactions ISO [Norepinephrine binds to and results in increased activity of ADRA2B protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA2B protein; Norepinephrine inhibits the reaction [ADRA2B protein binds to 2-methoxyidazoxan] CTD PMID:20030735 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987 		JBrowse link
G Adra2c adrenoceptor alpha 2C affects binding
multiple interactions		 ISO Norepinephrine binds to ADRA2C protein
[ADRA2A protein mutant form co-treated with ADRA2C protein mutant form] results in increased abundance of Norepinephrine
[Norepinephrine binds to and results in increased activity of ADRA2C protein] which results in increased abundance of Calcium; Norepinephrine binds to and results in increased activity of ADRA2C protein; Norepinephrine inhibits the reaction [ADRA2C protein binds to 2-methoxyidazoxan]		 CTD PMID:10336518 PMID:20030735 PMID:20083574 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions ISO
EXP		 [Norepinephrine binds to and results in increased activity of ADRB1 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB1 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB1 protein]; Norepinephrine inhibits the reaction [Iodocyanopindolol binds to ADRB1 protein]; Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB1 protein]; Propranolol inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRB1 protein]
[CGP 20712A binds to and results in decreased activity of ADRB1 protein] which results in decreased activity of Norepinephrine		 CTD PMID:8096834 PMID:10344530 PMID:12010770 PMID:14730417 PMID:17200720 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
affects binding		 EXP
ISO		 [ICI 118551 binds to and results in decreased activity of ADRB2 protein] inhibits the reaction [Fenoterol affects the abundance of Norepinephrine]
[Norepinephrine binds to and results in increased activity of ADRB2 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB2 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB2 protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB2 protein]; Propranolol inhibits the reaction [Norepinephrine binds to ADRB2 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]		 CTD PMID:7969507 PMID:10344530 PMID:14730417 PMID:24929186 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions
increases activity		 ISO
EXP		 [Norepinephrine binds to and results in increased activity of ADRB3 protein] which results in increased abundance of Cyclic AMP; Norepinephrine binds to and results in increased activity of ADRB3 protein; Norepinephrine inhibits the reaction [cyanopindolol binds to ADRB3 protein]; Octopamine inhibits the reaction [Norepinephrine binds to ADRB3 protein]
Norepinephrine results in increased activity of ADRB3 protein
3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Norepinephrine results in increased activity of ADRB3 protein]; Norepinephrine binds to and results in increased activity of ADRB3 protein		 CTD PMID:1682311 PMID:7815362 PMID:8569714 PMID:10344530 PMID:14730417 PMID:17622774 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632 		JBrowse link
G Agt angiotensinogen increases abundance
affects abundance
multiple interactions		 EXP AGT protein results in increased abundance of Norepinephrine
Norepinephrine affects the abundance of AGT protein
carvedilol inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]		 CTD PMID:614752 PMID:15741261 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance ISO AGTR2 protein affects the susceptibility to Norepinephrine CTD PMID:11714657 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression EXP Norepinephrine results in decreased expression of AKT1 protein modified form CTD PMID:16338971 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Anxa1 annexin A1 multiple interactions ISO ANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein] CTD PMID:16835395 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012 		JBrowse link
G Aqp2 aquaporin 2 decreases expression EXP Norepinephrine results in decreased expression of AQP2 protein CTD PMID:16788141 NCBI chr 7:141,237,802...141,242,837
Ensembl chr 7:141,237,768...141,245,165 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects abundance
decreases expression		 ISO
EXP		 ATP2A2 protein affects the abundance of Norepinephrine
Norepinephrine results in decreased expression of ATP2A2 mRNA		 CTD PMID:17592507 PMID:19328205 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326 		JBrowse link
G Avp arginine vasopressin multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA CTD PMID:11742803 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of BAX protein]
Norepinephrine results in increased expression of BAX mRNA; Norepinephrine results in increased expression of BAX protein		 CTD PMID:18675472 PMID:20374255 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in decreased expression of BCL2 protein] CTD PMID:14732211 PMID:17041759 PMID:20374255 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Norepinephrine results in decreased expression of BCL2L1 mRNA CTD PMID:18675472 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 affects the susceptibility to Norepinephrine CTD PMID:12105144 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676 		JBrowse link
G C5ar2 complement component 5a receptor 2 increases expression EXP Norepinephrine results in increased expression of C5AR2 mRNA; Norepinephrine results in increased expression of C5AR2 protein CTD PMID:15715664 NCBI chr 1:78,165,155...78,183,426
Ensembl chr 1:78,166,810...78,180,216 		JBrowse link
G Calca calcitonin-related polypeptide alpha affects response to substance
increases abundance
multiple interactions		 EXP CALCA protein affects the susceptibility to Norepinephrine
CALCA protein results in increased abundance of Norepinephrine
Propranolol promotes the reaction [CALCA protein affects the susceptibility to Norepinephrine]		 CTD PMID:8058111 PMID:18055875 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Caly calcyon neuron-specific vesicular protein increases secretion ISO CALY protein results in increased secretion of Norepinephrine CTD PMID:30753204 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477 		JBrowse link
G Casp12 caspase 12 multiple interactions
increases cleavage		 EXP CAT protein inhibits the reaction [Norepinephrine results in increased cleavage of CASP12 protein alternative form] CTD PMID:16338971 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp2 caspase 2 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP2 protein] CTD PMID:14732211 PMID:15158148 PMID:17041759 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression		 ISO
EXP		 Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein]; Norepinephrine results in increased activity of and results in increased cleavage of CASP3 protein
Norepinephrine results in increased activity of CASP3 protein
Norepinephrine results in increased cleavage of CASP3 protein
Norepinephrine results in increased expression of CASP3 protein
Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP3 protein]; N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of CASP3 protein]; Norepinephrine inhibits the reaction [Okadaic Acid results in increased activity of CASP3 protein]		 CTD PMID:11099166 PMID:14732211 PMID:15158148 PMID:16338971 PMID:17041759 PMID:17136323 PMID:18675472 PMID:20374255 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp6 caspase 6 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP6 protein] CTD PMID:14732211 PMID:15158148 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein]; Norepinephrine results in increased activity of and results in increased cleavage of CASP7 protein CTD PMID:17136323 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 affects activity EXP Norepinephrine affects the activity of CASP8 protein CTD PMID:25437044 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
affects activity
increases cleavage
increases activity		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased activity of CASP9 protein]
Norepinephrine affects the activity of CASP9 protein
Norepinephrine results in increased cleavage of CASP9 protein		 CTD PMID:14732211 PMID:15158148 PMID:16338971 PMID:25437044 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP CAT protein inhibits the reaction [Norepinephrine results in increased cleavage of CASP12 protein alternative form] CTD PMID:16338971 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]; Norepinephrine inhibits the reaction [Thioglycolates results in increased secretion of CCL3 protein]; Propranolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]] CTD PMID:9863660 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases secretion
multiple interactions		 ISO Norepinephrine results in increased secretion of CCL5 protein
Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein]		 CTD PMID:16782692 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Norepinephrine results in increased expression of CCN1 mRNA CTD PMID:15117851 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO Norepinephrine affects the expression of CNR1 mRNA CTD PMID:29650773 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression		 EXP carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA]; Doxazosin inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] CTD PMID:10722803 PMID:14577597 PMID:19575289 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions		 EXP Norepinephrine results in increased expression of COL3A1 mRNA
carvedilol inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA]		 CTD PMID:10722803 PMID:14577597 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions
increases methylation		 ISO [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine
COMT protein results in increased methylation of Norepinephrine		 CTD PMID:11160877 PMID:11248589 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression EXP Norepinephrine results in decreased expression of CPT1A mRNA CTD PMID:19109942 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678 		JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Norepinephrine results in increased expression of CREM mRNA CTD PMID:11171092 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases abundance		 EXP corticotropin releasing hormone (9-41) inhibits the reaction [CRH protein affects the abundance of Norepinephrine]; Norepinephrine affects the expression of and affects the secretion of CRH protein; Propranolol affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]; Yohimbine affects the reaction [Norepinephrine affects the expression of and affects the secretion of CRH protein]
CRH results in increased abundance of Norepinephrine		 CTD PMID:1320258 PMID:3497798 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine] CTD PMID:24398105 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645 		JBrowse link
G Cycs cytochrome c, somatic affects localization
increases localization		 EXP Norepinephrine affects the localization of CYCS protein
Norepinephrine results in increased localization of CYCS protein		 CTD PMID:16338971 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Dbh dopamine beta-hydroxylase affects abundance
increases abundance
decreases abundance		 ISO DBH gene polymorphism affects the abundance of Norepinephrine
DBH protein results in increased abundance of Norepinephrine
DBH mutant form results in decreased abundance of Norepinephrine		 CTD PMID:15148402 PMID:16163519 PMID:18329701 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Norepinephrine results in increased expression of DDIT3 mRNA; Norepinephrine results in increased expression of DDIT3 protein CTD PMID:16338971 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Norepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 mRNA]; Norepinephrine inhibits the reaction [Rotenone results in decreased expression of DRD1 protein] CTD PMID:20887679 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO
EXP		 [Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium; Sulpiride inhibits the reaction [[Norepinephrine binds to and results in increased activity of DRD2 protein alternative form] which results in decreased transport of Calcium]
Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 mRNA]; Norepinephrine inhibits the reaction [Rotenone results in increased expression of DRD2 protein]		 CTD PMID:8032591 PMID:20887679 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
increases activity
decreases secretion
increases secretion		 EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; [EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; BQ 610 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of EDN1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine]; Picrotoxin inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]
Norepinephrine results in increased activity of EDN1 promoter		 CTD PMID:11435416 PMID:12184995 PMID:14759557 PMID:16023617 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Edn3 endothelin 3 multiple interactions
decreases secretion
increases secretion		 EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; 2-aminoethoxydiphenyl borate inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; [EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; bisindolylmaleimide I inhibits the reaction [EDN3 protein results in increased secretion of Norepinephrine]; BQ 788 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]; KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine]; Picrotoxin inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 PMID:14759557 PMID:16023617 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450 		JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP [cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Norepinephrine CTD PMID:15834289 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP [EDN1 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine; [EDN3 protein binds to and results in increased activity of EDNRB protein] which results in decreased secretion of Norepinephrine CTD PMID:16023617 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Efhd2 EF-hand domain family, member D2 increases secretion ISO EFHD2 gene mutant form results in increased secretion of Norepinephrine CTD PMID:28397836 NCBI chr 5:160,407,777...160,423,811
Ensembl chr 5:160,407,778...160,423,811 		JBrowse link
G Egf epidermal growth factor multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA CTD PMID:11742803 PMID:12632255 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP EGFR protein inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Egr1 early growth response 1 increases expression EXP Norepinephrine results in increased expression of EGR1 CTD PMID:7905536 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions EXP [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of ELK1 protein] CTD PMID:11880281 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822 		JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 multiple interactions
increases expression		 ISO [Dexamethasone co-treated with Norepinephrine] results in increased expression of ELOVL3 mRNA; Dactinomycin inhibits the reaction [Norepinephrine results in increased expression of ELOVL3 mRNA]; Norepinephrine results in increased expression of and results in decreased degradation of ELOVL3 mRNA; rosiglitazone promotes the reaction [[Dexamethasone co-treated with Norepinephrine] results in increased expression of ELOVL3 mRNA] CTD PMID:17726147 NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226 		JBrowse link
G Epo erythropoietin decreases response to substance ISO EPO protein results in decreased susceptibility to Norepinephrine CTD PMID:14732207 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Norepinephrine promotes the reaction [REL protein binds to F3 promoter]; Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA] CTD PMID:23114885 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272 		JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]]; Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein] CTD PMID:11742803 PMID:15264218 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]] CTD PMID:11742803 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein; [Norepinephrine co-treated with Propranolol] results in increased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078 		JBrowse link
G Fndc5 fibronectin type III domain containing 5 decreases abundance EXP FNDC5 protein results in decreased abundance of Norepinephrine CTD PMID:32165127 NCBI chr 5:147,323,240...147,330,266
Ensembl chr 5:147,323,240...147,330,266 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO
EXP		 Norepinephrine results in increased expression of FOS mRNA
Norepinephrine results in increased expression of FOS; Norepinephrine results in increased expression of FOS mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of FOS mRNA]		 CTD PMID:7605896 PMID:7905536 PMID:12729908 PMID:19225867 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Norepinephrine results in increased expression of FOSB CTD PMID:7905536 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein] CTD PMID:19168439 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of G6PD mRNA; Norepinephrine results in increased activity of G6PD protein
Metoprolol inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]
Norepinephrine results in increased expression of G6PD mRNA		 CTD PMID:1378361 PMID:7605896 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926 		JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha multiple interactions EXP [Progesterone co-treated with Norepinephrine] results in increased expression of GABPA mRNA CTD PMID:16954335 NCBI chr11:24,293,845...24,322,822
Ensembl chr11:24,263,281...24,322,815 		JBrowse link
G Gk glycerol kinase increases activity
increases expression		 EXP Norepinephrine results in increased activity of GK protein
Norepinephrine results in increased expression of GK mRNA		 CTD PMID:12736183 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864 		JBrowse link
G Gnas GNAS complex locus multiple interactions ISO Norepinephrine promotes the reaction [ADRB1 protein results in increased activity of GNAS protein] CTD PMID:17200720 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483 		JBrowse link
G Hdc histidine decarboxylase affects abundance ISO HDC protein affects the abundance of Norepinephrine CTD PMID:12421355 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO Propranolol inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA] CTD PMID:24929186 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Norepinephrine results in increased expression of HSPA5 mRNA; Norepinephrine results in increased expression of HSPA5 protein CTD PMID:16338971 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B multiple interactions
increases expression		 EXP N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of HTR2B protein] CTD PMID:20374255 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]]; Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]; Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]; Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases response to substance		 EXP Prazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine] CTD PMID:17184500 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Il1b interleukin 1 beta affects secretion
increases expression
multiple interactions		 EXP Norepinephrine affects the secretion of IL1B protein
Norepinephrine results in increased expression of IL1B mRNA
carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL1B mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]		 CTD PMID:8392517 PMID:10722803 PMID:16386803 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases activity
decreases secretion		 ISO
EXP		 Norepinephrine results in increased expression of and results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [Norepinephrine results in increased expression of and results in increased secretion of IL6 protein]
Norepinephrine results in increased expression of IL6 mRNA; Norepinephrine results in increased expression of IL6 protein
Norepinephrine results in increased activity of IL6 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; ICI 118551 inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]; Norepinephrine promotes the reaction [IL1B protein results in increased expression of IL6 protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of IL6 mRNA]
Norepinephrine results in decreased secretion of IL6 protein
ANXA1 affects the reaction [Norepinephrine results in decreased secretion of IL6 protein]		 CTD PMID:8392517 PMID:10722803 PMID:11406463 PMID:12619890 PMID:14577597 PMID:16835395 PMID:18636164 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression		 EXP 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; bisindolylmaleimide inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased phosphorylation of JUN protein]; Tetradecanoylphorbol Acetate promotes the reaction [Norepinephrine results in increased expression of JUN mRNA]
Norepinephrine results in increased expression of JUN; Norepinephrine results in increased expression of JUN mRNA		 CTD PMID:7905536 PMID:19225867 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Norepinephrine results in increased expression of JUNB CTD PMID:7905536 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 affects response to substance EXP KCNMA1 protein affects the susceptibility to Norepinephrine CTD PMID:22226998 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein; Phenoxybenzamine inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Piperoxan inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein]; Prazosin inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein] CTD PMID:3953791 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724 		JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases expression		 EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA] CTD PMID:9032464 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Maoa monoamine oxidase A increases metabolic processing
increases abundance		 ISO MAOA protein results in increased metabolism of Norepinephrine
MAOA mutant form results in increased abundance of Norepinephrine		 CTD PMID:10647887 PMID:11834493 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B increases abundance ISO MAOB mutant form results in increased abundance of Norepinephrine CTD PMID:11834493 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Norepinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK1 protein]
Norepinephrine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK1 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK1 protein]		 CTD PMID:10788502 PMID:11054474 PMID:11880281 PMID:11914123 PMID:15292328 PMID:17041759 PMID:20434527 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine] CTD PMID:16949803 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 Norepinephrine inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK3 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; [Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein; [Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased phosphorylation of MAPK3 protein]; Cadmium Chloride inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; cadmium sulfate inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Carvedilol inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Egtazic Acid inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N,N'-bis(salicylideneamino)ethane-manganese(II) inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]; Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK3 protein; oxophenylarsine inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Trifluoperazine inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of and results in increased phosphorylation of MAPK3 protein]		 CTD PMID:10788502 PMID:11054474 PMID:11880281 PMID:11914123 PMID:15292328 PMID:17041759 PMID:20434527 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK8 protein] CTD PMID:17041759 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
affects response to substance		 ISO MAPK10 protein affects the reaction [MAPK9 protein affects the susceptibility to Norepinephrine] CTD PMID:16949803 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
increases activity		 EXP
ISO		 Cromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Norepinephrine results in increased activity of and results in increased expression of MMP2 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased activity of MMP2 protein]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]		 CTD PMID:14577597 PMID:15326086 PMID:16864425 PMID:24929186 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
increases activity		 EXP
ISO		 trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]
Norepinephrine results in increased activity of MMP9 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; Propranolol inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; SR 11302 inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]; tanshinone inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]		 CTD PMID:16864425 PMID:24929186 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 EXP [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA
Norepinephrine results in increased expression of MYC		 CTD PMID:7605896 PMID:12632255 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Myh6 myosin heavy chain 6 decreases expression EXP Norepinephrine results in decreased expression of MYH6 mRNA CTD PMID:17592507 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions
affects expression
increases expression		 EXP Propranolol promotes the reaction [Norepinephrine results in increased expression of MYH7 mRNA]
Norepinephrine affects the expression of MYH7 mRNA		 CTD PMID:17592507 PMID:25437044 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Norepinephrine results in increased expression of NFIL3 mRNA CTD PMID:12729908 NCBI chr17:12,261,102...12,276,316
Ensembl chr17:12,261,102...12,276,315 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 ISO Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Norepinephrine affects the localization of [NFKB1 protein binds to RELA protein]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; Norepinephrine promotes the reaction [NFKB1 protein binds to ICAM1 promoter]; Norepinephrine results in increased activity of [NFKB1 protein binds to RELA protein]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein] CTD PMID:16782692 PMID:23114885 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Ngf nerve growth factor decreases expression EXP Norepinephrine results in decreased expression of NGF mRNA; Norepinephrine results in decreased expression of NGF protein CTD PMID:8593794 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects response to substance		 ISO [GW 274150 results in decreased activity of NOS2 protein] which results in increased susceptibility to Norepinephrine; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Atenolol inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]; Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Norepinephrine		 CTD PMID:16424707 PMID:19439816 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions		 ISO
EXP		 Norepinephrine results in increased expression of NPPA mRNA
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Carvedilol inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Propranolol promotes the reaction [Norepinephrine results in increased expression of NPPA mRNA]		 CTD PMID:9788975 PMID:10722803 PMID:14577597 PMID:15240149 PMID:16714034 PMID:17266992 PMID:17592507 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Nppb natriuretic peptide B affects abundance
decreases abundance		 ISO NPPB affects the abundance of Norepinephrine
NPPB protein results in decreased abundance of Norepinephrine		 CTD PMID:16333235 PMID:20339970 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Npy neuropeptide Y affects response to substance ISO NPY protein affects the susceptibility to Norepinephrine CTD PMID:15003356 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
Ensembl chr 4:79,557,854...79,565,097 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP [Estradiol co-treated with Norepinephrine] results in decreased expression of NRF1 mRNA CTD PMID:16954335 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341 		JBrowse link
G Ntf3 neurotrophin 3 increases expression EXP Norepinephrine results in increased expression of NTF3 mRNA; Norepinephrine results in increased expression of NTF3 protein CTD PMID:19854260 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886 		JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity EXP Norepinephrine results in decreased activity of ODC1 protein CTD PMID:1850525 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP [dextrallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions EXP [dextrallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [dextrallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextromethorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextrorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levallorphan binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Levorphanol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadyl Acetate binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948 		JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Norepinephrine results in increased expression of PER1 mRNA CTD PMID:12729908 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994 		JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Norepinephrine results in increased expression of PER2 mRNA CTD PMID:12729908 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359 		JBrowse link
G Pgd phosphogluconate dehydrogenase multiple interactions
increases activity		 EXP carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased activity of PGD protein] CTD PMID:1378361 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Plcb1 phospholipase C beta 1 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCB1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]
Norepinephrine results in increased expression of PLCB1 mRNA; Norepinephrine results in increased expression of PLCB1 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545 		JBrowse link
G Plcb3 phospholipase C beta 3 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCB3 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]
Norepinephrine results in increased expression of PLCB3 mRNA; Norepinephrine results in increased expression of PLCB3 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910 		JBrowse link
G Plcd1 phospholipase C, delta 1 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCD1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]; pyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]
Norepinephrine results in increased expression of PLCD1 mRNA; Norepinephrine results in increased expression of PLCD1 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070 		JBrowse link
G Plcg1 phospholipase C, gamma 1 increases activity
multiple interactions
increases expression		 EXP Norepinephrine results in increased activity of PLCG1 protein
1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]; Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein]
Norepinephrine results in increased expression of PLCG1 mRNA; Norepinephrine results in increased expression of PLCG1 protein		 CTD PMID:16714034 PMID:19225867 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP Norepinephrine results in increased expression of PPARA mRNA CTD PMID:19109942 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP Norepinephrine results in increased expression of PPARG mRNA CTD PMID:19109942 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression		 ISO
EXP		 [Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]
Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PPARGC1A mRNA]		 CTD PMID:16513826 PMID:16954335 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP [Estradiol co-treated with Norepinephrine] results in decreased expression of PTEN mRNA; [Progesterone co-treated with Norepinephrine] results in increased expression of PTEN mRNA; Norepinephrine inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] CTD PMID:16954335 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Norepinephrine CTD PMID:15834289 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of REL protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of REL protein]; bisindolylmaleimide I inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]; Norepinephrine promotes the reaction [REL protein binds to F3 promoter]; Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of REL protein]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; REL mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]] CTD PMID:23114885 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine affects the localization of RELA protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]]; Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Ascorbic Acid inhibits the reaction [Norepinephrine affects the localization of RELA protein]; Norepinephrine affects the localization of [NFKB1 protein binds to RELA protein]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; Norepinephrine promotes the reaction [RELA protein binds to F3 promoter]; Norepinephrine promotes the reaction [RELA protein binds to ICAM1 promoter]; Norepinephrine results in increased activity of [NFKB1 protein binds to RELA protein]; prolinedithiocarbamate inhibits the reaction [Norepinephrine affects the localization of RELA protein]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of F3 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of ICAM1 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Vitamin E inhibits the reaction [Norepinephrine affects the localization of RELA protein] CTD PMID:16782692 PMID:23114885 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Norepinephrine results in increased expression of S100A8 mRNA; Norepinephrine results in increased expression of S100A8 protein CTD PMID:16677282 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Norepinephrine results in increased expression of S100A9 mRNA; Norepinephrine results in increased expression of S100A9 protein CTD PMID:16677282 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276 		JBrowse link
G S100b S100 calcium binding protein B increases expression
affects response to substance		 ISO Norepinephrine results in increased expression of S100B mRNA; Norepinephrine results in increased expression of S100B protein
S100B protein affects the susceptibility to Norepinephrine		 CTD PMID:9788975 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Norepinephrine results in increased expression of SCD1 mRNA CTD PMID:22413010 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO Norepinephrine results in increased expression of SERPINE1 mRNA CTD PMID:17429342 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Serpinh1 serpin family H member 1 multiple interactions
increases expression		 EXP carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 mRNA]; carvedilol inhibits the reaction [Norepinephrine results in increased expression of SERPINH1 protein]
Norepinephrine results in increased expression of SERPINH1 mRNA; Norepinephrine results in increased expression of SERPINH1 protein		 CTD PMID:10722803 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions
increases phosphorylation		 EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; bisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; EGFR protein inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; RTKI cpd inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; SHC1 protein affects the reaction [Norepinephrine results in decreased expression of SOD2 protein]; SHC1 protein affects the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form]; U 0126 inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression EXP Norepinephrine results in decreased expression of SLC12A1 protein CTD PMID:16788141 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367 		JBrowse link
G Slc14a2 solute carrier family 14 member 2 decreases expression EXP Norepinephrine results in decreased expression of SLC14A2 protein CTD PMID:16788141 NCBI chr18:74,508,070...74,941,389
Ensembl chr18:74,546,220...74,688,551
Ensembl chr18:74,546,220...74,688,551 		JBrowse link
G Slc18a1 solute carrier family 18 member A1 multiple interactions ISO Norepinephrine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] CTD PMID:8245983 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions
decreases activity
affects binding		 EXP
ISO		 Norepinephrine inhibits the reaction [SLC18A2 protein results in increased uptake of Serotonin]
Norepinephrine results in decreased activity of SLC18A2 protein
Norepinephrine binds to SLC18A2 protein		 CTD PMID:1438304 PMID:7912402 PMID:15475732 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 increases uptake
multiple interactions		 ISO
EXP		 SLC22A3 protein results in increased uptake of Norepinephrine
Norepinephrine affects the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]		 CTD PMID:9830022 PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
G Slc29a4 solute carrier family 29 member 4 increases uptake ISO SLC29A4 protein results in increased uptake of Norepinephrine CTD PMID:20858707 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 multiple interactions
increases uptake
decreases expression
decreases uptake
decreases activity		 ISO
EXP		 N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [SLC6A2 protein results in increased uptake of Norepinephrine]; Norepinephrine inhibits the reaction [nisoxetine binds to SLC6A2 protein]; SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]
Norepinephrine affects the localization of and affects the metabolism of SLC6A2 protein
[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine; Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; Lidocaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]; tricaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine]
Norepinephrine results in decreased expression of SLC6A2 protein
SLC6A2 mutant form results in decreased uptake of Norepinephrine
Norepinephrine results in decreased activity of SLC6A2 protein		 CTD PMID:11082428 PMID:11458707 PMID:16338971 PMID:16725121 PMID:17234900 PMID:30776375 NCBI chr19:15,391,682...15,431,274
Ensembl chr19:15,391,581...15,431,274 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
increases uptake		 ISO SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]
SLC6A3 protein results in increased uptake of Norepinephrine		 CTD PMID:17234900 PMID:17250655 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 increases expression EXP Norepinephrine results in increased expression of SLC8A1 mRNA; Norepinephrine results in increased expression of SLC8A1 protein CTD PMID:11179087 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression
increases expression
multiple interactions		 EXP
ISO		 Norepinephrine results in decreased expression of SOD2 protein
Norepinephrine results in increased expression of SOD2 mRNA
Acetylcysteine inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; NFKB1 mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Norepinephrine promotes the reaction [[NFKB1 protein binds to RELA protein] which binds to SOD2 promoter]; prolinedithiocarbamate inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; RELA mutant form inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]; Vitamin E inhibits the reaction [Norepinephrine results in increased expression of SOD2 mRNA]
SHC1 protein affects the reaction [Norepinephrine results in decreased expression of SOD2 protein]		 CTD PMID:19168439 PMID:23114885 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO SLC6A2 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]; SLC6A3 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein]; SLC6A4 protein promotes the reaction [Norepinephrine results in increased activity of TAAR1 protein] CTD PMID:17234900 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475 		JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions EXP [SQ 29548 binds to and results in decreased activity of TBXA2R protein] which results in decreased susceptibility to Norepinephrine CTD PMID:15834289 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP [Estradiol co-treated with Norepinephrine] results in decreased expression of TFAM mRNA; [Progesterone co-treated with Norepinephrine] results in increased expression of TFAM mRNA CTD PMID:16954335 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression		 EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB1 mRNA] CTD PMID:15326086 PMID:19575289 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression
multiple interactions		 EXP Norepinephrine results in increased expression of TGFB2 mRNA; Norepinephrine results in increased expression of TGFB2 protein
Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA]		 CTD PMID:15326086 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression
multiple interactions		 EXP Norepinephrine results in increased expression of TGFB3 mRNA
Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA]		 CTD PMID:15326086 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533 		JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases chemical synthesis		 EXP
ISO		 [Clonidine results in decreased activity of and results in decreased expression of TH protein] which results in decreased abundance of Norepinephrine; [Clonidine results in increased expression of TH protein] which results in increased abundance of Norepinephrine
TH protein results in increased chemical synthesis of Norepinephrine		 CTD PMID:9822156 PMID:19067675 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Thy1 Thy-1 cell surface antigen decreases expression
multiple interactions		 ISO Norepinephrine results in decreased expression of THY1
Propranolol inhibits the reaction [Norepinephrine results in decreased expression of THY1]		 CTD PMID:7558147 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions
increases expression		 EXP Metoprolol inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] CTD PMID:14577597 PMID:15326086 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion		 EXP Acetylcysteine inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Ascorbic Acid inhibits the reaction [Norepinephrine results in increased secretion of TNF protein]; Norepinephrine inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Norepinephrine promotes the reaction [TNF protein results in increased expression of IL6 protein]
Norepinephrine results in increased expression of TNF mRNA		 CTD PMID:8392517 PMID:15081246 PMID:15158148 PMID:25437044 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression		 ISO
EXP		 [Rosiglitazone results in increased susceptibility to Norepinephrine] which results in increased expression of UCP1 mRNA; [Rosiglitazone results in increased susceptibility to Norepinephrine] which results in increased expression of UCP1 protein; AG 1879 promotes the reaction [Norepinephrine results in increased expression of UCP1 mRNA]
[AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]]; [AVP protein co-treated with Norepinephrine] inhibits the reaction [Triiodothyronine results in increased expression of UCP1 mRNA]; [EGF protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [FGF1 protein co-treated with AVP protein co-treated with Norepinephrine co-treated with Triiodothyronine] results in decreased expression of UCP1 mRNA; [Triiodothyronine co-treated with Norepinephrine] results in increased expression of UCP1 mRNA		 CTD PMID:10465291 PMID:10788502 PMID:11742803 PMID:29910772 PMID:31048375 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
G Ucp2 uncoupling protein 2 increases expression EXP Norepinephrine results in increased expression of UCP2 mRNA CTD PMID:8593794 PMID:12588052 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Usf1 upstream transcription factor 1 multiple interactions ISO USF1 gene polymorphism promotes the reaction [Norepinephrine results in increased metabolism of Lipids]; USF1 protein affects the reaction [Norepinephrine results in increased metabolism of Lipids] CTD PMID:15985485 NCBI chr13:89,797,750...89,805,561
Ensembl chr13:89,797,800...89,805,558 		JBrowse link
G Vdr vitamin D receptor increases abundance ISO VDR protein results in increased abundance of Norepinephrine CTD PMID:27450565 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 ISO [Cobalt co-treated with Norepinephrine] results in increased expression of VEGFA mRNA; [Cycloheximide co-treated with Norepinephrine] results in increased expression of VEGFA mRNA; [Norepinephrine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA mRNA; AG 1879 inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; Cyclic AMP affects the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA]; Propranolol inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA] CTD PMID:10788502 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Xbp1 X-box binding protein 1 affects localization EXP Norepinephrine affects the localization of XBP1 protein CTD PMID:16338971 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
8-epi-prostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger4 prostaglandin E receptor 4 affects response to substance ISO PTGER4 protein affects the susceptibility to 8-isoprostaglandin E2 CTD PMID:22565502 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
8-epi-prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E multiple interactions ISO [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases abundance		 ISO [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha		 CTD PMID:22610977 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis		 ISO
EXP		 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]		 CTD PMID:11530235 PMID:16529823 PMID:19751497 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 affects metabolic processing
multiple interactions		 ISO PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]		 CTD PMID:18024956 NCBI chr 5:152,606,850...152,635,956
Ensembl chr 5:152,606,847...152,634,803 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha CTD PMID:8621535 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
affects response to substance		 ISO 8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha		 CTD PMID:18158556 PMID:22565502 NCBI chr 7:11,253,153...11,259,233
Ensembl chr 7:11,253,180...11,257,977 		JBrowse link
almotriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases methylation
increases hydroxylation
increases metabolic processing		 ISO CYP1A1 protein results in decreased methylation of almotriptan
CYP1A1 protein results in increased hydroxylation of almotriptan
CYP1A1 protein results in increased metabolism of almotriptan		 CTD PMID:12642466 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases methylation ISO CYP2C19 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases methylation ISO CYP2C8 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases methylation
increases hydroxylation		 ISO CYP2D6 protein results in decreased methylation of almotriptan
CYP2D6 protein results in increased hydroxylation of almotriptan		 CTD PMID:12642466 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases hydroxylation
decreases methylation		 ISO CYP3A4 protein results in increased hydroxylation of almotriptan
CYP3A4 protein results in decreased methylation of almotriptan		 CTD PMID:12642466 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of almotriptan CTD PMID:12642466 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11134654 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991 		JBrowse link
G Maoa monoamine oxidase A increases metabolic processing ISO MAOA protein results in increased metabolism of almotriptan CTD PMID:12642466 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
angiotensin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor, type 2 increases expression EXP Angiotensin II results in increased expression of AGTR2 mRNA; Angiotensin II results in increased expression of AGTR2 protein CTD PMID:12969123 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842 		JBrowse link
G Ednrb endothelin receptor type B increases expression EXP Angiotensin II results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO angiotensin II inhibits reaction [fluvastatin increases expression of Nphs1 protein in kidney] RGD PMID:19188342 RGD:38596324 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559 		JBrowse link
caesium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO cesium chloride inhibits the reaction [Acrolein results in increased expression of EDN1 protein] CTD PMID:22928487 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO cesium chloride inhibits the reaction [Acrolein results in increased expression of VEGFA protein] CTD PMID:22928487 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
carbocyclic thromboxane A2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression ISO thromboxane A2, carbocyclic results in decreased expression of TNFRSF11B mRNA CTD PMID:18264100 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665 		JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression ISO thromboxane A2, carbocyclic results in increased expression of TNFSF11 mRNA CTD PMID:18264100 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase affects expression EXP Cocaine affects the expression of AACS mRNA CTD PMID:20187946 NCBI chr12:36,512,393...36,555,694
Ensembl chr12:36,512,393...36,555,694 		JBrowse link
G Aadac arylacetamide deacetylase decreases expression EXP Cocaine results in decreased expression of AADAC mRNA CTD PMID:17898221 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480 		JBrowse link
G Aanat aralkylamine N-acetyltransferase affects response to substance ISO AANAT protein affects the susceptibility to Cocaine CTD PMID:12138020 NCBI chr10:105,568,091...105,572,407
Ensembl chr10:105,568,091...105,572,403 		JBrowse link
G Abat 4-aminobutyrate aminotransferase increases response to substance ISO ABAT mRNA results in increased susceptibility to Cocaine CTD PMID:10850552 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499 		JBrowse link
G Abca4 ATP binding cassette subfamily A member 4 decreases expression EXP Cocaine results in decreased expression of ABCA4 mRNA CTD PMID:27899881 NCBI chr 2:225,645,539...225,783,288
Ensembl chr 2:225,645,568...225,783,287 		JBrowse link
G Abca5 ATP binding cassette subfamily A member 5 multiple interactions ISO HDAC5 affects the reaction [Cocaine affects the expression of ABCA5 mRNA] CTD PMID:17988634 NCBI chr10:98,573,226...98,645,028
Ensembl chr10:98,576,039...98,644,938 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects expression EXP Cocaine affects the expression of ABCC3 mRNA CTD PMID:20187946 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 affects expression EXP Cocaine affects the expression of ABCC5 mRNA CTD PMID:20187946 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 affects expression EXP Cocaine affects the expression of ABCC9 mRNA CTD PMID:20187946 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424 		JBrowse link
G Abcd4 ATP binding cassette subfamily D member 4 affects expression EXP Cocaine affects the expression of ABCD4 mRNA CTD PMID:20187946 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464 		JBrowse link
G Abhd1 abhydrolase domain containing 1 decreases expression ISO Cocaine results in decreased expression of ABHD1 mRNA CTD PMID:18355967 NCBI chr 6:26,787,807...26,792,795
Ensembl chr 6:26,784,058...26,792,808 		JBrowse link
G Abhd14a abhydrolase domain containing 14A affects expression EXP Cocaine affects the expression of ABHD14A mRNA CTD PMID:20187946 NCBI chr 8:115,141,575...115,151,222
Ensembl chr 8:115,141,539...115,149,527 		JBrowse link
G Abhd17a abhydrolase domain containing 17A, depalmitoylase affects expression EXP Cocaine affects the expression of ABHD17A mRNA CTD PMID:20187946 NCBI chr 7:11,992,543...12,000,978
Ensembl chr 7:11,992,543...11,998,973 		JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase affects expression ISO Cocaine affects the expression of ABL1 mRNA CTD PMID:15681117 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
Ensembl chr 3:10,041,826...10,144,388 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Cocaine results in increased expression of ACAA1 mRNA CTD PMID:18355967 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acan aggrecan affects expression EXP Cocaine affects the expression of ACAN mRNA CTD PMID:20187946 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441 		JBrowse link
G Ace angiotensin I converting enzyme multiple interactions ISO ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone]; ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol] CTD PMID:14738173 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 affects expression ISO Cocaine affects the expression of ACIN1 mRNA CTD PMID:15681117 NCBI chr15:33,288,369...33,333,256
Ensembl chr15:33,288,374...33,333,417 		JBrowse link
G Ackr2 atypical chemokine receptor 2 affects expression EXP Cocaine affects the expression of ACKR2 mRNA CTD PMID:20187946 NCBI chr 8:130,526,521...130,543,566
Ensembl chr 8:130,538,651...130,542,227 		JBrowse link
G Aco2 aconitase 2 increases expression ISO Cocaine results in increased expression of ACO2 protein modified form CTD PMID:24096156 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 affects expression EXP Cocaine affects the expression of ACSL5 mRNA CTD PMID:20187946 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 decreases expression EXP Cocaine results in decreased expression of ACSS1 mRNA CTD PMID:27899881 NCBI chr 3:146,420,346...146,470,293
Ensembl chr 3:146,420,346...146,470,293 		JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression ISO Cocaine results in decreased expression of ACTG2 mRNA CTD PMID:20948987 NCBI chr 4:115,215,160...115,239,746
Ensembl chr 4:115,215,060...115,239,723 		JBrowse link
G Actn2 actinin alpha 2 increases expression ISO Cocaine results in increased expression of ACTN2 mRNA CTD PMID:15009677 PMID:16710320 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653 		JBrowse link
G Acvr1c activin A receptor type 1C increases expression EXP Cocaine results in increased expression of ACVR1C mRNA CTD PMID:17898221 NCBI chr 3:44,272,859...44,342,501
Ensembl chr 3:44,270,653...44,342,355 		JBrowse link
G Acy3 aminoacylase 3 affects expression EXP Cocaine affects the expression of ACY3 mRNA CTD PMID:20187946 NCBI chr 1:219,233,712...219,237,103
Ensembl chr 1:219,233,750...219,237,098 		JBrowse link
G Adam19 ADAM metallopeptidase domain 19 decreases expression EXP Cocaine results in decreased expression of ADAM19 mRNA CTD PMID:17898221 NCBI chr10:31,146,107...31,240,582
Ensembl chr10:31,146,107...31,240,582 		JBrowse link
G Adam1a ADAM metallopeptidase domain 1a multiple interactions ISO HDAC5 affects the reaction [Cocaine affects the expression of ADAM1A mRNA] CTD PMID:17988634 NCBI chr12:40,533,731...40,536,632
Ensembl chr12:40,533,632...40,536,620 		JBrowse link
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 decreases expression EXP Cocaine results in decreased expression of ADAMTS19 mRNA CTD PMID:27899881 NCBI chr18:53,915,807...54,099,856
Ensembl chr18:53,915,807...54,099,120 		JBrowse link
G Adat2 adenosine deaminase, tRNA-specific 2 decreases expression EXP Cocaine results in decreased expression of ADAT2 mRNA CTD PMID:17898221 NCBI chr 1:7,726,447...7,743,112
Ensembl chr 1:7,726,529...7,742,484 		JBrowse link
G Adcy2 adenylate cyclase 2 affects expression EXP Cocaine affects the expression of ADCY2 mRNA CTD PMID:20187946 NCBI chr 1:37,043,071...37,698,390
Ensembl chr 1:37,507,276...37,698,390 		JBrowse link
G Adcy8 adenylate cyclase 8 affects expression EXP Cocaine affects the expression of ADCY8 mRNA CTD PMID:20187946 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 increases expression
multiple interactions		 ISO Cocaine results in increased expression of ADCYAP1 mRNA
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; ADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1 mRNA]		 CTD PMID:29673861 NCBI chr 9:121,705,897...121,725,736
Ensembl chr 9:121,706,979...121,725,716 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I increases expression
multiple interactions		 ISO Cocaine results in increased expression of ADCYAP1R1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; IL6 protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]; TNF protein affects the reaction [Cocaine results in increased expression of ADCYAP1R1 mRNA]		 CTD PMID:29673861 NCBI chr 4:85,662,809...85,711,696
Ensembl chr 4:85,662,892...85,711,696 		JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in increased expression of ADGRA1 mRNA CTD PMID:18355967 NCBI chr 1:212,170,190...212,213,156
Ensembl chr 1:212,181,374...212,211,578 		JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 affects expression EXP Cocaine affects the expression of ADGRE1 mRNA CTD PMID:20187946 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865 		JBrowse link
G Adgrf1 adhesion G protein-coupled receptor F1 decreases expression EXP Cocaine results in decreased expression of ADGRF1 mRNA CTD PMID:17898221 NCBI chr 9:20,343,730...20,378,686 JBrowse link
G Adgrl1 adhesion G protein-coupled receptor L1 affects expression EXP Cocaine affects the expression of ADGRL1 mRNA CTD PMID:20187946 NCBI chr19:25,029,037...25,069,146
Ensembl chr19:25,029,037...25,069,142 		JBrowse link
G Adgrl3 adhesion G protein-coupled receptor L3 affects expression EXP Cocaine affects the expression of ADGRL3 mRNA CTD PMID:20187946 NCBI chr14:28,362,176...29,226,085
Ensembl chr14:28,393,394...28,967,980 		JBrowse link
G Adora1 adenosine A1 receptor affects expression
affects response to substance		 EXP
ISO		 Cocaine affects the expression of ADORA1 mRNA; Cocaine affects the expression of ADORA1 protein
ADORA1 affects the susceptibility to Cocaine		 CTD PMID:12358776 PMID:19092996 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Adora2a adenosine A2a receptor increases response to substance
increases expression		 ISO ADORA2A results in increased susceptibility to Cocaine
Cocaine deficiency results in increased expression of ADORA2A mRNA		 CTD PMID:16123743 PMID:27126842 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873 		JBrowse link
G Adora2b adenosine A2B receptor affects expression EXP Cocaine affects the expression of ADORA2B mRNA CTD PMID:20187946 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365 		JBrowse link
G Adra1b adrenoceptor alpha 1B increases response to substance ISO ADRA1B gene results in increased susceptibility to Cocaine CTD PMID:14556232 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Adrb1 adrenoceptor beta 1 multiple interactions
affects expression		 EXP Betaxolol affects the reaction [Cocaine affects the expression of ADRB1 protein]; Betaxolol inhibits the reaction [Cocaine affects the expression of ADRB1 protein] CTD PMID:17513029 PMID:18596687 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985 		JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression EXP Cocaine results in increased expression of AFF4 mRNA CTD PMID:17898221 NCBI chr10:38,692,167...38,773,021
Ensembl chr10:38,692,211...38,773,021 		JBrowse link
G Afmid arylformamidase increases expression EXP Cocaine results in increased expression of AFMID mRNA CTD PMID:17898221 NCBI chr10:106,828,963...106,844,314
Ensembl chr10:106,828,981...106,844,314 		JBrowse link
G Afp alpha-fetoprotein increases expression EXP Cocaine results in increased expression of AFP mRNA CTD PMID:27899881 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 affects expression EXP Cocaine affects the expression of AGAP2 mRNA CTD PMID:20187946 NCBI chr 7:70,360,199...70,377,422
Ensembl chr 7:70,364,813...70,377,422 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 multiple interactions
affects response to substance		 ISO AGO2 protein affects the reaction [Cocaine results in increased expression of MIR130A mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR136 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR137 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR138-1 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR148B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR154 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR181A1 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR186 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR301B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR324 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR337 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR369 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376A mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR376C mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR380 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR384 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR467B mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR500 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR544 mRNA]; AGO2 protein affects the reaction [Cocaine results in increased expression of MIR665 mRNA]
AGO2 protein affects the susceptibility to Cocaine		 CTD PMID:20643829 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613 		JBrowse link
G Aif1l allograft inflammatory factor 1-like decreases expression ISO Cocaine results in decreased expression of AIF1L mRNA CTD PMID:15009677 NCBI chr 3:9,237,944...9,262,628
Ensembl chr 3:9,237,944...9,262,628 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects expression
increases expression		 ISO Cocaine affects the expression of AIFM1 mRNA
Cocaine results in increased expression of AIFM1 mRNA		 CTD PMID:15681117 PMID:18000554 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 affects expression ISO Cocaine affects the expression of AIFM2 mRNA CTD PMID:15681117 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906 		JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Cocaine results in decreased expression of AK1 mRNA CTD PMID:15009677 NCBI chr 3:11,652,143...11,659,135 JBrowse link
G Ak3 adenylate kinase 3 affects expression EXP Cocaine affects the expression of AK3 mRNA CTD PMID:20187946 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693 		JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects expression EXP Cocaine affects the expression of AKR1D1 mRNA CTD PMID:20187946 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941 		JBrowse link
G Akr1e2 aldo-keto reductase family 1, member E2 affects expression EXP Cocaine affects the expression of AKR1E1 mRNA CTD PMID:20187946 NCBI chr17:69,365,437...69,379,944
Ensembl chr17:69,365,453...69,379,947 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 affects expression EXP Cocaine affects the expression of AKR7A3 mRNA CTD PMID:20187946 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Cocaine affects the expression of AKT1 mRNA
[Cocaine co-treated with cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester] results in increased phosphorylation of AKT1 protein
Cocaine results in increased phosphorylation of AKT1 protein
Cocaine affects the reaction [ILK protein affects the phosphorylation of AKT1 protein]		 CTD PMID:18702665 PMID:20187946 PMID:25933444 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression EXP Cocaine results in increased expression of ALCAM mRNA CTD PMID:17898221 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]; [ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine; ALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine] CTD PMID:20729865 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752 		JBrowse link
G Ambra1 autophagy and beclin 1 regulator 1 decreases expression EXP Cocaine results in decreased expression of AMBRA1 mRNA CTD PMID:17898221 NCBI chr 3:80,634,470...80,830,068
Ensembl chr 3:80,634,470...80,830,068 		JBrowse link
G Amh anti-Mullerian hormone increases expression EXP Cocaine results in increased expression of AMH mRNA CTD PMID:17898221 NCBI chr 7:11,775,155...11,777,503
Ensembl chr 7:11,775,155...11,777,503 		JBrowse link
G Amigo1 adhesion molecule with Ig like domain 1 affects expression EXP Cocaine affects the expression of AMIGO1 mRNA CTD PMID:20187946 NCBI chr 2:210,977,125...210,982,582
Ensembl chr 2:210,977,938...210,982,579 		JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 affects expression EXP Cocaine affects the expression of AMIGO3 mRNA CTD PMID:20187946 NCBI chr 8:116,830,773...116,832,299 JBrowse link
G Amn1 antagonist of mitotic exit network 1 homolog decreases expression EXP Cocaine results in decreased expression of AMN1 mRNA CTD PMID:17898221 NCBI chr 4:183,670,589...183,697,531
Ensembl chr 4:183,670,596...183,697,531 		JBrowse link
G Ankrd54 ankyrin repeat domain 54 affects expression EXP Cocaine affects the expression of ANKRD54 mRNA CTD PMID:20187946 NCBI chr 7:120,282,423...120,295,647
Ensembl chr 7:120,282,822...120,295,618 		JBrowse link
G Anks1b ankyrin repeat and sterile alpha motif domain containing 1B decreases expression EXP Cocaine results in decreased expression of ANKS1B mRNA CTD PMID:17898221 NCBI chr 7:30,507,135...31,684,604
Ensembl chr 7:30,699,476...31,681,182 		JBrowse link
G Anxa7 annexin A7 affects expression EXP Cocaine affects the expression of ANXA7 mRNA CTD PMID:20187946 NCBI chr15:4,254,470...4,281,296
Ensembl chr15:4,254,499...4,281,287 		JBrowse link
G Ap1ar adaptor-related protein complex 1 associated regulatory protein increases expression EXP Cocaine results in increased expression of AP1AR mRNA CTD PMID:17898221 NCBI chr 2:232,146,418...232,178,813
Ensembl chr 2:232,147,690...232,178,671 		JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 affects expression EXP Cocaine affects the expression of AP2B1 mRNA CTD PMID:20187946 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977 		JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 increases expression EXP Cocaine results in increased expression of AP2M1 protein CTD PMID:25100957 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546 		JBrowse link
G Ap2s1 adaptor related protein complex 2 subunit sigma 1 decreases expression ISO Cocaine results in decreased expression of AP2S1 mRNA CTD PMID:15009677 NCBI chr 1:78,671,238...78,682,847
Ensembl chr 1:78,671,121...78,682,871 		JBrowse link
G Ap5m1 adaptor related protein complex 5 subunit mu 1 affects expression EXP Cocaine affects the expression of AP5M1 mRNA CTD PMID:20187946 NCBI chr15:25,933,483...25,955,745
Ensembl chr15:25,933,483...25,955,745 		JBrowse link
G Apcs amyloid P component, serum increases expression ISO Cocaine results in increased expression of APCS protein CTD PMID:12714198 NCBI chr13:91,426,621...91,427,417
Ensembl chr13:91,426,479...91,427,575 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit affects expression EXP Cocaine affects the expression of APH1A mRNA CTD PMID:20187946 NCBI chr 2:198,006,247...198,009,837
Ensembl chr 2:198,006,316...198,009,830 		JBrowse link
G Aplnr apelin receptor increases expression EXP Cocaine results in increased expression of APLNR mRNA CTD PMID:17898221 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182 		JBrowse link
G Apol11a apolipoprotein L 11a decreases expression EXP Cocaine results in decreased expression of APOL11A mRNA CTD PMID:27899881 NCBI chr 7:118,835,316...118,858,347
Ensembl chr 7:118,836,547...118,840,634 		JBrowse link
G Apol2 apolipoprotein L, 2 increases expression ISO Cocaine results in increased expression of APOL2 mRNA CTD PMID:17205118 NCBI chr 7:118,727,658...118,735,453
Ensembl chr 7:118,728,617...118,732,738
Ensembl chr 7:118,728,617...118,732,738 		JBrowse link
G Apold1 apolipoprotein L domain containing 1 affects expression EXP Cocaine affects the expression of APOLD1 mRNA CTD PMID:20187946 NCBI chr 4:168,752,142...168,755,024
Ensembl chr 4:168,752,133...168,755,023 		JBrowse link
G Apoo apolipoprotein O increases expression EXP Cocaine results in increased expression of APOO protein CTD PMID:25100957 NCBI chr  X:63,521,033...63,625,134
Ensembl chr  X:63,520,991...63,625,134 		JBrowse link
G App amyloid beta precursor protein decreases expression
increases expression		 EXP
ISO		 Cocaine results in decreased expression of APP mRNA
Cocaine results in increased expression of APP mRNA		 CTD PMID:15009677 PMID:16710320 PMID:17898221 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 increases expression EXP Cocaine results in increased expression of APPL1 mRNA CTD PMID:17898221 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression
increases expression
multiple interactions		 EXP Cocaine affects the expression of ARC mRNA
Cocaine results in increased expression of ARC mRNA; Cocaine results in increased expression of ARC protein
Reserpine inhibits the reaction [Cocaine results in increased expression of ARC mRNA]		 CTD PMID:7722525 PMID:12117546 PMID:15254092 PMID:17851536 PMID:18311559 PMID:18361437 PMID:20187946 PMID:24810662 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Arf4 ADP-ribosylation factor 4 decreases expression EXP Cocaine results in decreased expression of ARF4 protein CTD PMID:25100957 NCBI chr16:2,338,333...2,354,909
Ensembl chr16:2,338,333...2,354,909 		JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression EXP Cocaine results in increased expression of ARHGAP1 protein CTD PMID:25100957 NCBI chr 3:80,555,196...80,576,881
Ensembl chr 3:80,555,196...80,576,856 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO Cocaine results in decreased expression of ARHGAP29 mRNA CTD PMID:12629581 NCBI chr 2:225,552,075...225,613,349
Ensembl chr 2:225,552,148...225,613,359 		JBrowse link
G Arhgap30 Rho GTPase activating protein 30 increases expression EXP Cocaine results in increased expression of ARHGAP30 mRNA CTD PMID:17898221 NCBI chr13:89,774,764...89,796,113
Ensembl chr13:89,774,764...89,796,113 		JBrowse link
G Arhgap44 Rho GTPase activating protein 44 decreases expression EXP Cocaine results in decreased expression of ARHGAP44 protein CTD PMID:25100957 NCBI chr10:51,501,547...51,669,546
Ensembl chr10:51,502,894...51,669,297 		JBrowse link
G Arhgap5 Rho GTPase activating protein 5 increases expression EXP Cocaine results in increased expression of ARHGAP5 mRNA CTD PMID:17898221 NCBI chr 6:73,345,129...73,408,304
Ensembl chr 6:73,345,392...73,405,880 		JBrowse link
G Arhgap9 Rho GTPase activating protein 9 decreases expression EXP Cocaine results in decreased expression of ARHGAP9 mRNA CTD PMID:17898221 NCBI chr 7:70,612,650...70,620,900
Ensembl chr 7:70,612,103...70,620,890 		JBrowse link
G Arhgef1 Rho guanine nucleotide exchange factor 1 affects expression EXP Cocaine affects the expression of ARHGEF1 mRNA CTD PMID:20187946 NCBI chr 1:81,769,212...81,797,237
Ensembl chr 1:81,779,380...81,797,236 		JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 affects expression EXP Cocaine affects the expression of ARHGEF7 mRNA CTD PMID:20187946 NCBI chr16:83,006,732...83,117,065
Ensembl chr16:83,006,718...83,132,785 		JBrowse link
G Armcx6 armadillo repeat containing, X-linked 6 affects expression EXP Cocaine affects the expression of ARMCX6 mRNA CTD PMID:20187946 NCBI chr  X:105,565,733...105,573,387
Ensembl chr  X:105,565,747...105,568,343 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression ISO Cocaine results in decreased expression of ARNTL mRNA CTD PMID:15994025 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465 		JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A increases expression EXP Cocaine results in increased expression of ARPC1A protein CTD PMID:25100957 NCBI chr12:11,272,609...11,294,084
Ensembl chr12:11,272,609...11,294,058 		JBrowse link
G Arpp19 cAMP-regulated phosphoprotein 19 multiple interactions EXP Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP19 protein] CTD PMID:11268215 NCBI chr 8:81,949,577...81,972,054
Ensembl chr 8:81,949,877...81,968,589 		JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 multiple interactions
increases expression		 EXP
ISO		 Cocaine inhibits the reaction [SK&F 81297 results in increased phosphorylation of ARPP21 protein]
Cocaine deficiency results in increased expression of ARPP21 mRNA		 CTD PMID:11268215 PMID:27126842 NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507 		JBrowse link
G Art5 ADP-ribosyltransferase 5 increases expression EXP Cocaine results in increased expression of ART5 mRNA CTD PMID:17898221 NCBI chr 1:167,192,809...167,202,767
Ensembl chr 1:167,192,810...167,202,767 		JBrowse link
G As3mt arsenite methyltransferase affects expression EXP Cocaine affects the expression of AS3MT mRNA CTD PMID:20187946 NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569 		JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 decreases expression EXP Cocaine results in decreased expression of ASAP1 mRNA CTD PMID:17898221 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045 		JBrowse link
G Atad1 ATPase family, AAA domain containing 1 increases expression EXP Cocaine results in increased expression of ATAD1 mRNA CTD PMID:17898221 NCBI chr 1:251,234,702...251,386,996
Ensembl chr 1:251,235,508...251,387,002 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 decreases expression EXP Cocaine results in decreased expression of ATAD5 mRNA CTD PMID:17898221 NCBI chr10:67,427,042...67,475,825
Ensembl chr10:67,427,066...67,473,649 		JBrowse link
G Ate1 arginyltransferase 1 increases expression EXP Cocaine results in increased expression of ATE1 mRNA CTD PMID:17898221 NCBI chr 1:200,810,741...200,885,593
NCBI chr 1:200,958,564...201,082,100
Ensembl chr 1:200,810,771...201,082,727 		JBrowse link
G Atf3 activating transcription factor 3 increases expression
decreases expression		 EXP Cocaine results in increased expression of ATF3 mRNA
Cocaine results in decreased expression of ATF3 mRNA		 CTD PMID:23644055 PMID:27899881 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Cocaine results in increased expression of ATF4; Cocaine results in increased expression of ATF4 mRNA CTD PMID:18593214 PMID:23644055 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772 		JBrowse link
G Atf6 activating transcription factor 6 affects expression EXP Cocaine affects the expression of ATF6 mRNA CTD PMID:23644055 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Atf7 activating transcription factor 7 affects expression ISO Cocaine affects the expression of ATF7 mRNA CTD PMID:15681117 NCBI chr 7:144,131,382...144,223,463
Ensembl chr 7:144,136,325...144,223,429 		JBrowse link
G Atg2b autophagy related 2B affects expression EXP Cocaine affects the expression of ATG2B mRNA CTD PMID:20187946 NCBI chr 6:129,449,451...129,519,599
Ensembl chr 6:129,449,449...129,509,720 		JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase affects expression EXP Cocaine affects the expression of ATG4B mRNA CTD PMID:20187946 NCBI chr 9:100,888,457...100,920,123
Ensembl chr 9:100,888,501...100,918,637 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases expression		 ISO EHMT2 inhibits the reaction [Cocaine results in increased expression of ATM mRNA] CTD PMID:20056891 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atp10a ATPase phospholipid transporting 10A (putative) decreases expression EXP Cocaine results in decreased expression of ATP10A mRNA CTD PMID:17898221 PMID:27899881 NCBI chr 1:115,973,343...116,141,892
Ensembl chr 1:115,975,324...116,141,892 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 affects expression ISO Cocaine affects the expression of ATP1A1 mRNA CTD PMID:18355967 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression
affects expression		 EXP Cocaine results in increased expression of ATP1A3 mRNA
Cocaine affects the expression of ATP1A3 mRNA		 CTD PMID:16076954 PMID:20187946 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549 		JBrowse link
G Atp1b2 ATPase Na+/K+ transporting subunit beta 2 increases expression EXP Cocaine results in increased expression of ATP1B2 mRNA CTD PMID:16076954 NCBI chr10:56,205,622...56,211,879
Ensembl chr10:56,205,625...56,211,891 		JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 increases expression
multiple interactions		 ISO Cocaine results in increased expression of ATP1B3 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP1B3 mRNA]		 CTD PMID:18355967 NCBI chr 8:104,190,032...104,221,342
Ensembl chr 8:104,190,032...104,221,342 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects expression ISO Cocaine affects the expression of ATP5F1A protein CTD PMID:19393250 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta decreases expression ISO Cocaine results in decreased expression of ATP5F1B protein CTD PMID:17075605 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749 		JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon affects expression EXP Cocaine affects the expression of ATP5F1E mRNA CTD PMID:20187946 NCBI chr 3:172,563,105...172,566,007
Ensembl chr 3:172,563,105...172,566,010 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 decreases expression
affects expression		 ISO
EXP		 Cocaine results in decreased expression of ATP5MC3 mRNA
Cocaine affects the expression of ATP5MC3 mRNA		 CTD PMID:12629581 PMID:20187946 NCBI chr 3:60,811,218...60,813,903
Ensembl chr 3:60,811,210...60,813,869 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b affects expression EXP Cocaine affects the expression of ATP5PB mRNA CTD PMID:20187946 NCBI chr 2:208,566,385...208,577,147
Ensembl chr 2:208,566,385...208,577,146
Ensembl chr 2:208,566,385...208,577,146 		JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d affects expression EXP Cocaine affects the expression of ATP5H mRNA CTD PMID:12358776 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668 		JBrowse link
G Atp6v1d ATPase H+ transporting V1 subunit D affects expression EXP Cocaine affects the expression of ATP6V1D mRNA CTD PMID:20187946 NCBI chr 6:102,032,271...102,047,754
Ensembl chr 6:102,032,276...102,047,758 		JBrowse link
G Atp8b2 ATPase phospholipid transporting 8B2 increases expression
multiple interactions		 ISO Cocaine results in increased expression of ATP8B2 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of ATP8B2 mRNA]		 CTD PMID:18355967 NCBI chr 2:189,285,961...189,306,947
Ensembl chr 2:189,285,953...189,307,108 		JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) affects response to substance ISO ATP9B gene SNP affects the susceptibility to Cocaine CTD PMID:18438686 NCBI chr18:77,343,551...77,535,608
Ensembl chr18:77,343,551...77,535,593 		JBrowse link
G Atpaf1 ATP synthase mitochondrial F1 complex assembly factor 1 multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in decreased expression of ATPAF1 mRNA CTD PMID:18355967 NCBI chr 5:134,641,618...134,667,079
Ensembl chr 5:134,641,608...134,667,084 		JBrowse link
G Atrx ATRX, chromatin remodeler increases expression EXP Cocaine results in increased expression of ATRX mRNA CTD PMID:17898221 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878 		JBrowse link
G Atxn1 ataxin 1 affects expression EXP Cocaine affects the expression of ATXN1 mRNA CTD PMID:20187946 NCBI chr17:19,160,986...19,533,814
Ensembl chr17:19,249,952...19,533,814 		JBrowse link
G Atxn3 ataxin 3 decreases expression ISO Cocaine results in decreased expression of ATXN3 mRNA CTD PMID:12629581 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461 		JBrowse link
G Azgp1 alpha-2-glycoprotein 1, zinc-binding decreases expression EXP Cocaine results in decreased expression of AZGP1 mRNA CTD PMID:17898221 NCBI chr12:19,196,565...19,203,094
Ensembl chr12:19,196,611...19,202,647 		JBrowse link
G Baalc BAALC binder of MAP3K1 and KLF4 decreases expression ISO Cocaine results in decreased expression of BAALC mRNA CTD PMID:18355967 NCBI chr 7:77,761,056...77,836,534
Ensembl chr 7:77,763,512...77,837,453 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 increases expression EXP Cocaine results in increased expression of BACH1 mRNA CTD PMID:17898221 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
Ensembl chr11:27,364,916...27,398,842 		JBrowse link
G Bach2 BTB domain and CNC homolog 2 affects expression ISO Cocaine affects the expression of BACH2 mRNA CTD PMID:15681117 NCBI chr 5:47,458,891...47,807,176
Ensembl chr 5:47,546,014...47,807,166 		JBrowse link
G Bad BCL2-associated agonist of cell death affects expression ISO Cocaine affects the expression of BAD mRNA CTD PMID:15681117 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bag1 BAG cochaperone 1 affects expression ISO Cocaine affects the expression of BAG1 mRNA CTD PMID:15681117 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002 		JBrowse link
G Bag3 BAG cochaperone 3 affects expression
increases expression		 ISO
EXP		 Cocaine affects the expression of BAG3 mRNA
Cocaine results in increased expression of BAG3 mRNA		 CTD PMID:15681117 PMID:27899881 NCBI chr 1:199,941,258...199,965,191
Ensembl chr 1:199,941,161...199,965,191 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor affects expression EXP Cocaine affects the expression of BAMBI mRNA CTD PMID:20187946 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 affects expression EXP Cocaine affects the expression of BASP1 mRNA CTD PMID:20187946 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
increases activity
affects expression		 ISO
EXP		 Cocaine results in increased expression of BAX mRNA
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased expression of BAX protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased expression of BAX protein]; IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [Cocaine results in increased expression of BAX protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased expression of BAX protein]]
Cocaine results in increased activity of BAX protein
Cocaine affects the expression of BAX mRNA		 CTD PMID:11392460 PMID:15681117 PMID:15685203 PMID:17084983 PMID:17635674 PMID:18974856 PMID:20948987 PMID:29673861 PMID:30393195 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B multiple interactions
increases expression		 ISO [SMARCA5 protein co-treated with BAZ1B protein] results in increased susceptibility to Cocaine; Cocaine promotes the reaction [BAZ1B protein binds to SPHKAP gene]; Cocaine results in increased expression of and affects the activity of BAZ1B protein
Cocaine results in increased expression of BAZ1B mRNA		 CTD PMID:27053203 NCBI chr12:24,478,882...24,536,851
Ensembl chr12:24,478,898...24,537,313 		JBrowse link
G Baz2b bromodomain adjacent to zinc finger domain, 2B increases expression EXP Cocaine results in increased expression of BAZ2B mRNA CTD PMID:17898221 NCBI chr 3:45,968,845...46,286,915
Ensembl chr 3:45,968,825...46,153,371 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 affects expression EXP Cocaine affects the expression of BCAP31 mRNA CTD PMID:20187946 NCBI chr  X:157,094,365...157,126,397
Ensembl chr  X:157,095,937...157,126,393 		JBrowse link
G Bcat1 branched chain amino acid transaminase 1 affects expression EXP Cocaine affects the expression of BCAT1 mRNA CTD PMID:20187946 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795 		JBrowse link
G Bche butyrylcholinesterase affects metabolic processing
multiple interactions
increases hydrolysis
increases metabolic processing
decreases response to substance
affects hydrolysis
decreases metabolic processing
affects degradation		 ISO BCHE protein affects the metabolism of Cocaine
[BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of Benzoic Acid; [BCHE protein mutant form results in increased metabolism of Cocaine] which results in increased chemical synthesis of ecgonine methyl ester
[BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of Benzoic Acid; [BCHE protein mutant form results in increased hydrolysis of Cocaine] which results in increased abundance of ecgonine methyl ester
BCHE protein mutant form results in increased metabolism of Cocaine; BCHE protein results in increased metabolism of Cocaine
BCHE protein mutant form results in decreased susceptibility to Cocaine
BCHE protein modified form results in increased hydrolysis of Cocaine; BCHE protein mutant form results in increased hydrolysis of Cocaine
BCHE protein affects the hydrolysis of Cocaine
BCHE protein mutant form results in decreased metabolism of Cocaine
BCHE protein mutant form affects the degradation of Cocaine		 CTD PMID:572161 PMID:16275916 PMID:17989928 PMID:18514178 PMID:18514640 PMID:19067679 PMID:20060817 PMID:20219449 PMID:20971807 PMID:22917637 PMID:22960160 PMID:24582612 PMID:25814464 PMID:27154495 PMID:30080993 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl11b BAF chromatin remodeling complex subunit BCL11B increases expression ISO Cocaine deficiency results in increased expression of BCL11B mRNA CTD PMID:27126842 NCBI chr 6:131,834,097...131,927,251
Ensembl chr 6:131,834,097...131,926,272 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
decreases expression
increases phosphorylation
increases expression		 ISO
EXP		 Cocaine affects the expression of BCL2 mRNA
IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2 protein]]
Cocaine results in increased phosphorylation of BCL2 protein
6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; 7-(hydroxyimino)cyclopropan(b)chromen-1a-carbxoylic acid ethyl ester inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; Dizocilpine Maleate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]; SCH 23390 inhibits the reaction [Cocaine results in increased phosphorylation of BCL2 protein]
Cocaine results in decreased expression of BCL2 mRNA; Cocaine results in decreased expression of BCL2 protein
Cocaine results in increased expression of BCL2 protein		 CTD PMID:11392460 PMID:15365088 PMID:15681117 PMID:15685203 PMID:17084983 PMID:18974856 PMID:19183502 PMID:19879923 PMID:29673861 PMID:30393195 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression
decreases expression
multiple interactions		 EXP
ISO		 Cocaine results in increased expression of BCL2L1 mRNA; Cocaine results in increased expression of BCL2L1 mRNA alternative form
Cocaine results in decreased expression of BCL2L1 protein
IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; PRKCD protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; rottlerin inhibits the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in decreased expression of BCL2L1 protein]]		 CTD PMID:16076954 PMID:29673861 PMID:30393195 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bcl2l11 BCL2 like 11 increases expression EXP Cocaine results in increased expression of BCL2L11 mRNA CTD PMID:16076954 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance
increases expression
decreases activity
affects expression
multiple interactions
decreases expression
increases response to substance		 ISO
EXP		 BDNF mRNA results in decreased susceptibility to Cocaine; BDNF protein results in decreased susceptibility to Cocaine
Cocaine results in increased expression of BDNF mRNA
Cocaine results in decreased activity of BDNF protein
Cocaine results in increased expression of BDNF protein
Cocaine affects the expression of BDNF exon; Cocaine affects the expression of BDNF mRNA; Cocaine affects the expression of BDNF protein
BDNF protein inhibits the reaction [Cocaine results in increased abundance of Amino Acids, Peptides, and Proteins]; Cocaine affects the activity of and affects the expression of BDNF protein; Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]; Cocaine affects the reaction [MECP2 protein affects the expression of BDNF protein]; Cocaine affects the reaction [MECP2 protein binds to and results in decreased activity of BDNF promoter]; Cocaine affects the reaction [MIR212 protein affects the expression of BDNF protein]
BDNF mRNA results in decreased susceptibility to Cocaine; BDNF protein results in decreased susceptibility to Cocaine; BDNF results in decreased susceptibility to Cocaine
(+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]; (+)-JQ1 compound inhibits the reaction [Cocaine results in increased expression of BDNF mRNA]; Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]; Cocaine inhibits the reaction [MECP2 protein binds to BDNF promoter]; Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]; FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of BDNF mRNA]; Haloperidol inhibits the reaction [Cocaine results in decreased expression of BDNF protein]
Cocaine results in decreased expression of BDNF mRNA; Cocaine results in decreased expression of BDNF protein
BDNF results in increased susceptibility to Cocaine		 CTD PMID:12099907 PMID:14973246 PMID:16423334 PMID:17194538 PMID:17618281 PMID:18311559 PMID:18355967 PMID:19321768 PMID:20554863 PMID:20711185 PMID:20810894 PMID:20826313 PMID:24358339 PMID:26558777 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Begain brain-enriched guanylate kinase-associated affects expression EXP Cocaine affects the expression of BEGAIN mRNA CTD PMID:20187946 NCBI chr 6:132,936,964...132,972,569
Ensembl chr 6:132,936,970...132,972,511 		JBrowse link
G Bhlhe22 basic helix-loop-helix family, member e22 increases expression EXP Cocaine results in increased expression of BHLHE22 mRNA CTD PMID:17898221 NCBI chr 2:102,685,513...102,688,624
Ensembl chr 2:102,685,513...102,688,624 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 affects expression EXP Cocaine affects the expression of BHLHE40 mRNA CTD PMID:20187946 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319 		JBrowse link
G Bid BH3 interacting domain death agonist affects expression ISO Cocaine affects the expression of BID mRNA CTD PMID:15681117 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bik BCL2-interacting killer affects expression ISO Cocaine affects the expression of BIK mRNA CTD PMID:15681117 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447 		JBrowse link
G Bmp2k BMP-2 inducible kinase affects expression EXP Cocaine affects the expression of BMP2K mRNA CTD PMID:20187946 NCBI chr14:14,126,086...14,226,823
Ensembl chr14:14,129,725...14,192,048 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 increases expression EXP Cocaine results in increased expression of BMPR2 mRNA CTD PMID:17898221 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494 		JBrowse link
G Bnip2 BCL2 interacting protein 2 affects expression ISO Cocaine affects the expression of BNIP2 mRNA CTD PMID:15681117 NCBI chr 8:76,400,333...76,426,307
Ensembl chr 8:76,400,341...76,426,503 		JBrowse link
G Bnip3 BCL2 interacting protein 3 affects expression ISO Cocaine affects the expression of BNIP3 mRNA CTD PMID:15681117 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like affects expression ISO Cocaine affects the expression of BNIP3L mRNA CTD PMID:15681117 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Brd4 bromodomain containing 4 multiple interactions
increases expression		 ISO
EXP		 (+)-JQ1 compound inhibits the reaction [Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]]; Cocaine promotes the reaction [BRD4 protein binds to BDNF promoter]
Cocaine results in increased expression of BRD4 protein		 CTD PMID:26558777 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055 		JBrowse link
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin affects expression EXP Cocaine affects the expression of BSCL2 mRNA CTD PMID:20187946 NCBI chr 1:225,035,956...225,046,137
Ensembl chr 1:225,037,737...225,046,040 		JBrowse link
G Bst1 bone marrow stromal cell antigen 1 affects expression EXP Cocaine affects the expression of BST1 mRNA CTD PMID:20187946 NCBI chr14:71,798,218...71,814,540
Ensembl chr14:71,798,651...71,814,523 		JBrowse link
G Btbd9 BTB domain containing 9 increases expression EXP Cocaine results in increased expression of BTBD9 mRNA CTD PMID:17898221 NCBI chr20:8,899,286...9,253,936
Ensembl chr20:8,901,931...9,249,820 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 affects expression EXP Cocaine affects the expression of BTG2 mRNA CTD PMID:20187946 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982 		JBrowse link
G Btk Bruton tyrosine kinase decreases expression EXP Cocaine results in decreased expression of BTK mRNA CTD PMID:17898221 NCBI chr  X:105,360,922...105,390,580
Ensembl chr  X:105,360,922...105,390,580 		JBrowse link
G C1qbp complement C1q binding protein decreases expression EXP Cocaine results in decreased expression of C1QBP protein CTD PMID:25100957 NCBI chr10:57,613,876...57,618,527
Ensembl chr10:57,613,879...57,618,527 		JBrowse link
G C1qtnf1 C1q and TNF related 1 affects expression EXP Cocaine affects the expression of C1QTNF1 mRNA CTD PMID:20187946 NCBI chr10:107,455,845...107,477,160
Ensembl chr10:107,455,845...107,477,162 		JBrowse link
G C1qtnf4 C1q and TNF related 4 decreases expression EXP Cocaine results in decreased expression of C1QTNF4 mRNA CTD PMID:17898221 NCBI chr 3:79,713,580...79,718,018
Ensembl chr 3:79,713,567...79,718,025 		JBrowse link
G C2cd3 C2 domain containing 3 centriole elongation regulator decreases expression EXP Cocaine results in decreased expression of C2CD3 mRNA CTD PMID:17898221 NCBI chr 1:165,382,279...165,480,088
Ensembl chr 1:165,382,690...165,479,655 		JBrowse link
G C2cd4d C2 calcium-dependent domain containing 4D decreases expression EXP Cocaine results in decreased expression of C2CD4D mRNA CTD PMID:27899881 NCBI chr 2:195,599,706...195,604,730
Ensembl chr 2:195,603,599...195,604,624 		JBrowse link
G Ca4 carbonic anhydrase 4 decreases expression EXP Cocaine results in decreased expression of CAR4 mRNA CTD PMID:17898221 NCBI chr10:72,272,286...72,281,069
Ensembl chr10:72,272,248...72,281,067 		JBrowse link
G Cab39l calcium binding protein 39-like multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in increased expression of CAB39L mRNA CTD PMID:18355967 NCBI chr15:39,745,124...39,849,022
Ensembl chr15:39,759,257...39,870,208 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D affects response to substance ISO CACNA1D polymorphism affects the susceptibility to Cocaine CTD PMID:28194001 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 affects expression EXP Cocaine affects the expression of CACNB3 mRNA CTD PMID:20187946 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902 		JBrowse link
G Cald1 caldesmon 1 affects expression EXP Cocaine affects the expression of CALD1 mRNA CTD PMID:20187946 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489 		JBrowse link
G Calm1 calmodulin 1 decreases expression ISO Cocaine results in decreased expression of CALM1 mRNA CTD PMID:17205118 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292 		JBrowse link
G Calm2 calmodulin 2 decreases expression ISO Cocaine results in decreased expression of CALM2 mRNA CTD PMID:17205118 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968 		JBrowse link
G Calr calreticulin decreases expression
multiple interactions
affects expression		 ISO
EXP		 Cocaine results in decreased expression of CALR mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of CALR mRNA]
Cocaine affects the expression of CALR mRNA		 CTD PMID:18355967 PMID:20187946 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666 		JBrowse link
G Caly calcyon neuron-specific vesicular protein increases expression EXP Cocaine results in increased expression of CALY mRNA CTD PMID:20171207 NCBI chr 1:212,537,851...212,549,040
Ensembl chr 1:212,537,848...212,549,477 		JBrowse link
G Camk1g calcium/calmodulin-dependent protein kinase IG multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in increased expression of CAMK1G mRNA CTD PMID:18355967 NCBI chr13:112,075,689...112,099,472
Ensembl chr13:112,075,690...112,099,336 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha affects response to substance
multiple interactions
increases expression		 ISO
EXP		 CAMK2A affects the susceptibility to Cocaine
Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein; Nifedipine inhibits the reaction [Cocaine results in increased expression of and results in increased phosphorylation of CAMK2A protein]
Cocaine results in increased expression of CAMK2A protein
7-chlorokynurenic acid inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]; Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]; Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein; KN 93 inhibits the reaction [Cocaine promotes the reaction [DRD3 protein binds to CAMK2A protein]]; Sodium Benzoate promotes the reaction [Cocaine results in increased phosphorylation of and results in increased activity of CAMK2A protein]		 CTD PMID:14725635 PMID:17609678 PMID:19217379 PMID:28194001 NCBI chr18:56,193,978...56,295,869
Ensembl chr18:56,193,978...56,295,869 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression
affects expression		 ISO
EXP		 Cocaine results in decreased expression of CAMK2B mRNA
Cocaine affects the expression of CAMK2B mRNA		 CTD PMID:17205118 PMID:20187946 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV increases response to substance
decreases response to substance		 ISO CAMK4 promoter SNP results in increased susceptibility to Cocaine
CAMK4 protein results in decreased susceptibility to Cocaine		 CTD PMID:19001277 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957 		JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 affects expression EXP Cocaine affects the expression of CAP2 mRNA CTD PMID:20187946 NCBI chr17:18,441,614...18,592,866
Ensembl chr17:18,442,127...18,592,750 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta decreases expression ISO Cocaine results in decreased expression of CAPZB mRNA CTD PMID:12629581 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478 		JBrowse link
G Card11 caspase recruitment domain family, member 11 decreases expression EXP Cocaine results in decreased expression of CARD11 mRNA CTD PMID:27899881 NCBI chr12:15,700,600...15,844,512
Ensembl chr12:15,700,825...15,844,512 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 affects expression EXP Cocaine affects the expression of CARM1 mRNA CTD PMID:20187946 NCBI chr 8:22,577,723...22,622,555
Ensembl chr 8:22,577,715...22,622,560 		JBrowse link
G Carnmt1 carnosine N-methyltransferase 1 affects expression EXP Cocaine affects the expression of CARNMT1 mRNA CTD PMID:20187946 NCBI chr 1:234,675,442...234,704,856
Ensembl chr 1:234,677,692...234,704,792 		JBrowse link
G Cartpt CART prepropeptide increases expression
affects expression		 ISO
EXP		 Cocaine results in increased expression of CARTPT mRNA
Cocaine affects the expression of CARTPT mRNA		 CTD PMID:15009677 PMID:17851536 PMID:20187946 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269 		JBrowse link
G Casp2 caspase 2 increases activity
increases expression		 EXP Cocaine results in increased activity of CASP2 protein
Cocaine results in increased expression of CASP2 mRNA		 CTD PMID:16076954 PMID:16638611 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions
increases activity
affects expression		 ISO
EXP		 Cocaine results in increased expression of CASP3 protein
Cocaine results in increased cleavage of CASP3 protein
ADCYAP1 protein modified form affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; PRKCD protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; rottlerin inhibits the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]; TNF protein affects the reaction [IL6 protein affects the reaction [Cocaine results in increased cleavage of CASP3 protein]]
Cocaine results in increased activity of CASP3 protein
Cocaine affects the expression of CASP3 protein
[Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Cocaine results in increased cleavage of and results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein]; SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP3 protein]
Cocaine affects the expression of CASP3 mRNA		 CTD PMID:10604926 PMID:11392460 PMID:12639677 PMID:14741756 PMID:15365088 PMID:15681117 PMID:16179556 PMID:16638611 PMID:16686379 PMID:17084983 PMID:17635674 PMID:18974856 PMID:19183502 PMID:20600547 PMID:29673861 PMID:30393195 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp4 caspase 4 affects expression
decreases expression		 ISO Cocaine affects the expression of CASP4 mRNA
Cocaine results in decreased expression of CASP4 mRNA		 CTD PMID:12629581 PMID:15681117 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652 		JBrowse link
G Casp8 caspase 8 affects expression
increases activity		 ISO
EXP		 Cocaine affects the expression of CASP8 mRNA
Cocaine results in increased activity of CASP8 protein		 CTD PMID:11392460 PMID:15681117 PMID:18974856 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 affects expression
increases activity
multiple interactions
increases expression		 ISO
EXP		 Cocaine affects the expression of CASP9 mRNA
Cocaine results in increased activity of CASP9 protein
SB 203580 inhibits the reaction [Cocaine results in increased activity of CASP9 protein]
Cocaine affects the expression of CASP9 protein
Cocaine results in increased expression of CASP9 protein		 CTD PMID:10604926 PMID:11392460 PMID:12639677 PMID:15365088 PMID:15681117 PMID:16179556 PMID:16638611 PMID:16686379 PMID:17084983 PMID:17635674 PMID:18974856 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 affects expression EXP Cocaine affects the expression of CASTOR1 mRNA CTD PMID:20187946 NCBI chr14:84,447,552...84,457,396
Ensembl chr14:84,447,885...84,452,367 		JBrowse link
G Cat catalase decreases activity
increases activity
increases expression		 ISO
EXP		 Cocaine results in decreased activity of CAT protein
Cocaine results in increased activity of CAT protein
Cocaine results in increased expression of CAT protein		 CTD PMID:14576513 PMID:16085363 PMID:29475069 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Catsper2 cation channel, sperm associated 2 increases expression EXP Cocaine results in increased expression of CATSPER2 mRNA CTD PMID:17898221 NCBI chr 3:113,357,361...113,379,498
Ensembl chr 3:113,357,365...113,376,751 		JBrowse link
G Cbln1 cerebellin 1 precursor multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in increased expression of CBLN1 mRNA CTD PMID:18355967 NCBI chr19:20,607,507...20,611,316
Ensembl chr19:20,607,507...20,611,316 		JBrowse link
G Ccdc127 coiled-coil domain containing 127 increases expression EXP Cocaine results in increased expression of CCDC127 mRNA CTD PMID:17898221 NCBI chr 1:31,538,088...31,545,573
Ensembl chr 1:31,539,215...31,545,559 		JBrowse link
G Ccdc174 coiled-coil domain containing 174 affects expression EXP Cocaine affects the expression of CCDC174 mRNA CTD PMID:20187946 NCBI chr 4:123,760,708...123,787,529
Ensembl chr 4:123,760,743...123,787,528 		JBrowse link
G Ccdc73 coiled-coil domain containing 73 decreases expression EXP Cocaine results in decreased expression of CCDC73 mRNA CTD PMID:17898221 NCBI chr 3:94,848,775...94,989,984
Ensembl chr 3:94,848,823...94,986,263 		JBrowse link
G Ccdc88a coiled coil domain containing 88A increases expression EXP Cocaine results in increased expression of CCDC88A mRNA CTD PMID:17898221 NCBI chr14:113,771,093...113,936,376
Ensembl chr14:113,867,209...113,932,263 		JBrowse link
G Ccdc93 coiled-coil domain containing 93 increases expression EXP Cocaine results in increased expression of CCDC93 mRNA CTD PMID:17898221 NCBI chr13:37,400,455...37,473,973
Ensembl chr13:37,400,476...37,468,840 		JBrowse link
G Cckbr cholecystokinin B receptor decreases expression
increases response to substance		 ISO Cocaine results in decreased expression of CCKBR mRNA
CCKBR protein results in increased susceptibility to Cocaine		 CTD PMID:11403953 PMID:18000554 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion
increases expression
multiple interactions		 ISO
EXP		 Cocaine results in increased secretion of CCL2 protein
Cocaine results in increased expression of CCL2 mRNA; Cocaine results in increased expression of CCL2 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; AG 1879 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; Cocaine promotes the reaction [RELA protein binds to CCL2 promoter]; methyl-beta-cyclodextrin inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; pyrazolanthrone inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; RELA mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SC 514 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; SIGMAR1 mutant form inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; U 0126 inhibits the reaction [Cocaine results in increased expression of CCL2 protein]		 CTD PMID:10065903 PMID:20354174 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Cocaine results in increased secretion of CCL3 protein CTD PMID:10065903 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO Cocaine results in decreased expression of CCN2 mRNA; Cocaine results in decreased expression of CCN2 protein CTD PMID:18000554 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Ccn3 cellular communication network factor 3 increases expression EXP Cocaine results in increased expression of CCN3 mRNA CTD PMID:17898221 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO
EXP		 Cocaine results in decreased expression of CCNA2 mRNA CTD PMID:18593214 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd1 cyclin D1 affects expression EXP Cocaine affects the expression of CCND1 mRNA CTD PMID:20187946 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccnd3 cyclin D3 affects expression EXP Cocaine affects the expression of CCND3 mRNA CTD PMID:20187946 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943 		JBrowse link
G Ccnl1 cyclin L1 increases expression EXP Cocaine results in increased expression of CCNL1 mRNA CTD PMID:16076954 NCBI chr 2:157,747,295...157,759,838
Ensembl chr 2:157,747,542...157,759,838 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 affects expression
increases response to substance		 EXP
ISO		 Cocaine affects the expression of CCR2 mRNA
CCR2 results in increased susceptibility to Cocaine		 CTD PMID:20187946 PMID:20354174
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO Cocaine results in increased expression of CCR5 protein CTD PMID:16204638 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 affects response to substance ISO CCSER1 gene SNP affects the susceptibility to Cocaine CTD PMID:18438686 NCBI chr 4:91,235,885...92,516,800
Ensembl chr 4:91,373,942...91,972,325 		JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 affects expression EXP Cocaine affects the expression of CCT2 mRNA CTD PMID:20187946 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805 		JBrowse link
G Cd180 CD180 molecule decreases expression EXP Cocaine results in decreased expression of CD180 mRNA CTD PMID:27899881 NCBI chr 2:32,820,275...32,833,223
Ensembl chr 2:32,820,322...32,833,125 		JBrowse link
G Cd276 Cd276 molecule affects expression EXP Cocaine affects the expression of CD276 mRNA CTD PMID:20187946 NCBI chr 8:63,312,060...63,350,411
Ensembl chr 8:63,318,019...63,350,269 		JBrowse link
G Cd4 Cd4 molecule multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in decreased expression of CD4 mRNA CTD PMID:18355967 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO Cocaine results in decreased expression of CD44 mRNA CTD PMID:18000554 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Cd47 Cd47 molecule affects expression EXP Cocaine affects the expression of CD47 mRNA CTD PMID:20187946 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175 		JBrowse link
G Cd74 CD74 molecule affects expression EXP Cocaine affects the expression of CD74 mRNA CTD PMID:20187946 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Cd81 Cd81 molecule increases response to substance
increases expression
affects response to substance		 ISO
EXP		 CD81 protein results in increased susceptibility to Cocaine
Cocaine results in increased expression of CD81 mRNA
CD81 protein affects the susceptibility to Cocaine		 CTD PMID:11178868 PMID:12113778 PMID:15715673 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311 		JBrowse link
G Cd93 CD93 molecule decreases expression EXP Cocaine results in decreased expression of CD93 mRNA CTD PMID:17898221 NCBI chr 3:142,778,798...142,783,774
Ensembl chr 3:142,778,770...142,783,774 		JBrowse link
G Cdc14b cell division cycle 14B decreases expression EXP Cocaine results in decreased expression of CDC14B mRNA CTD PMID:17898221 NCBI chr17:1,709,703...1,797,732
Ensembl chr17:1,703,943...1,797,750 		JBrowse link
G Cdc25a cell division cycle 25A increases expression EXP Cocaine results in increased expression of CDC25A mRNA CTD PMID:17898221 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519 		JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Cocaine results in decreased expression of CDH1 mRNA CTD PMID:12629581 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh16 cadherin 16 affects expression EXP Cocaine affects the expression of CDH16 mRNA CTD PMID:20187946 NCBI chr19:568,329...578,513
Ensembl chr19:568,287...578,520 		JBrowse link
G Cdh17 cadherin 17 decreases expression ISO Cocaine results in decreased expression of CDH17 mRNA CTD PMID:12629581 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718 		JBrowse link
G Cdk18 cyclin-dependent kinase 18 affects expression EXP Cocaine affects the expression of CDK18 mRNA CTD PMID:20187946 NCBI chr13:48,893,525...48,926,673
Ensembl chr13:48,893,412...48,927,483 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 affects expression ISO Cocaine affects the expression of CDK4 mRNA CTD PMID:18355967 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 affects expression
increases expression
decreases expression		 EXP Cocaine affects the expression of CDK5 mRNA; Cocaine affects the expression of CDK5 protein
Cocaine results in increased expression of CDK5 mRNA; Cocaine results in increased expression of CDK5 protein
Cocaine results in decreased expression of CDK5 protein		 CTD PMID:11268215 PMID:12787079 PMID:16263094 PMID:17339080 PMID:17680995 PMID:20187946 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 CDK5R1 protein inhibits the reaction [Cocaine affects the expression of FOS mRNA]; CDK5R1 protein inhibits the reaction [Cocaine results in increased expression of FOS protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAP2K2 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK1 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of MAPK3 protein]; CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]
Cocaine results in increased expression of CDK5R1 mRNA; Cocaine results in increased expression of CDK5R1 protein
Cocaine results in decreased expression of CDK5R1 protein		 CTD PMID:11268215 PMID:15665076 PMID:16263094 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Cocaine results in increased expression of CDKN1A mRNA CTD PMID:27899881 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Ceacam4 CEA cell adhesion molecule 4 affects expression EXP Cocaine affects the expression of CEACAM3 mRNA CTD PMID:20187946 NCBI chr 1:81,643,809...81,650,085
Ensembl chr 1:81,643,816...81,650,094
Ensembl chr 1:81,643,816...81,650,094 		JBrowse link
G Cel carboxyl ester lipase increases expression EXP Cocaine results in increased expression of CEL mRNA CTD PMID:27899881 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
affects binding		 ISO CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol]; Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
CES1 protein results in increased hydrolysis of Cocaine
Cocaine binds to CES1 protein		 CTD PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 PMID:25445008 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
decreases expression
increases hydrolysis		 ISO Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin]
Cocaine results in decreased expression of CES2 mRNA
CES2 protein results in increased hydrolysis of Cocaine		 CTD PMID:8930175 PMID:9169443 PMID:12629581 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156 		JBrowse link
G Cfh complement factor H decreases expression EXP Cocaine results in decreased expression of CFH mRNA CTD PMID:17898221 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator affects expression ISO Cocaine affects the expression of CFLAR mRNA CTD PMID:15681117 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains affects expression EXP Cocaine affects the expression of CHFR mRNA CTD PMID:20187946 NCBI chr12:52,562,594...52,596,162
Ensembl chr12:52,562,597...52,596,076 		JBrowse link
G Chn1 chimerin 1 affects expression EXP Cocaine affects the expression of CHN1 mRNA CTD PMID:20187946 NCBI chr 3:60,512,360...60,668,413
Ensembl chr 3:60,513,077...60,611,924 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects expression EXP Cocaine affects the expression of CHRM4 mRNA CTD PMID:20187946 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 decreases response to substance EXP CHRM5 mutant form results in decreased susceptibility to Cocaine CTD PMID:20393457 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]] CTD PMID:10336510 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:10336510 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit decreases response to substance ISO CHRNA5 gene polymorphism results in decreased susceptibility to Cocaine CTD PMID:18519132 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions
increases response to substance		 EXP
ISO		 Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA3 protein binds to CHRNB2 protein]]; Cocaine inhibits the reaction [Nicotine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]
CHRNB2 protein results in increased susceptibility to Cocaine		 CTD PMID:10336510 PMID:11282258 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit increases expression EXP Cocaine results in increased expression of CHRNE mRNA CTD PMID:27899881 NCBI chr10:57,238,960...57,246,750
Ensembl chr10:57,238,946...57,243,435 		JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 decreases expression EXP Cocaine results in decreased expression of CHTF8 mRNA CTD PMID:17898221 NCBI chr19:39,077,580...39,087,880
Ensembl chr19:39,077,580...39,087,880 		JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Cocaine results in decreased expression of CHURC1 mRNA CTD PMID:15009677 PMID:16710320 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576 		JBrowse link
G Ciao1 cytosolic iron-sulfur assembly component 1 affects expression EXP Cocaine affects the expression of CIAO1 mRNA CTD PMID:20187946 NCBI chr 3:119,671,778...119,677,324
Ensembl chr 3:119,671,779...119,678,092 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a affects expression ISO Cocaine affects the expression of CIDEA mRNA CTD PMID:15681117 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051 		JBrowse link
G Cideb cell death-inducing DFFA-like effector b affects expression ISO Cocaine affects the expression of CIDEB mRNA CTD PMID:15681117 NCBI chr15:34,439,844...34,444,244
Ensembl chr15:34,439,876...34,444,244 		JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 increases expression EXP Cocaine results in increased expression of CISD1 protein CTD PMID:25100957 NCBI chr20:18,493,538...18,506,923
Ensembl chr20:18,493,538...18,506,912 		JBrowse link
G Cisd2 CDGSH iron sulfur domain 2 increases expression EXP Cocaine results in increased expression of CISD2 mRNA CTD PMID:17898221 NCBI chr 2:240,586,754...240,611,560
Ensembl chr 2:240,586,754...240,611,560 		JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 decreases expression EXP Cocaine results in decreased expression of CITED4 mRNA CTD PMID:27899881 NCBI chr 5:139,597,731...139,598,622
Ensembl chr 5:139,597,731...139,598,622 		JBrowse link
G Ckb creatine kinase B multiple interactions ISO Cocaine results in increased secretion of [CKB protein binds to CKM protein] CTD PMID:12359538 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions ISO Cocaine results in increased secretion of [CKB protein binds to CKM protein] CTD PMID:12359538 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841 		JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 affects expression EXP Cocaine affects the expression of CKMT1 mRNA CTD PMID:20187946 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461 		JBrowse link
G Clcn7 chloride voltage-gated channel 7 affects expression EXP Cocaine affects the expression of CLCN7 mRNA CTD PMID:20187946 NCBI chr10:14,492,844...14,518,167
Ensembl chr10:14,492,844...14,516,894 		JBrowse link
G Cldn11 claudin 11 decreases expression ISO Cocaine results in decreased expression of CLDN11 mRNA CTD PMID:18357522 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846 		JBrowse link
G Clec4f C-type lectin domain family 4, member F affects expression EXP Cocaine affects the expression of CLEC4F mRNA CTD PMID:20187946 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052 		JBrowse link
G Clic1 chloride intracellular channel 1 decreases expression ISO Cocaine results in decreased expression of CLIC1 mRNA CTD PMID:18000554 NCBI chr20:5,040,314...5,049,166
Ensembl chr20:5,040,337...5,049,166 		JBrowse link
G Clip1 CAP-GLY domain containing linker protein 1 increases expression ISO Cocaine results in increased expression of CLIP1 mRNA CTD PMID:18000554 NCBI chr12:38,345,203...38,452,650
Ensembl chr12:38,345,456...38,452,652 		JBrowse link
G Clk1 CDC-like kinase 1 increases expression
multiple interactions		 ISO Cocaine results in increased expression of CLK1 mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CLK1 mRNA]		 CTD PMID:18355967 NCBI chr 9:65,296,777...65,308,017
Ensembl chr 9:65,296,778...65,307,995 		JBrowse link
G Clk4 CDC-like kinase 4 increases expression ISO Cocaine results in increased expression of CLK4 mRNA CTD PMID:20056891 NCBI chr10:36,715,565...36,733,473
Ensembl chr10:36,715,565...36,733,133 		JBrowse link
G Clock clock circadian regulator increases expression ISO Cocaine results in increased expression of CLOCK mRNA CTD PMID:15994025 NCBI chr14:34,418,226...34,502,218
Ensembl chr14:34,446,616...34,502,218 		JBrowse link
G Cltb clathrin, light chain B decreases expression ISO Cocaine results in decreased expression of CLTB mRNA CTD PMID:12629581 PMID:15009677 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989 		JBrowse link
G Clybl citramalyl-CoA lyase increases expression EXP Cocaine results in increased expression of CLYBL protein CTD PMID:25100957 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235 		JBrowse link
G Cnbd2 cyclic nucleotide binding domain containing 2 increases expression EXP Cocaine results in increased expression of CNBD2 mRNA CTD PMID:17898221 NCBI chr 3:152,382,245...152,448,105
Ensembl chr 3:152,402,520...152,465,228 		JBrowse link
G Cnksr2 connector enhancer of kinase suppressor of Ras 2 increases expression ISO Cocaine results in increased expression of CNKSR2 mRNA CTD PMID:15009677 NCBI chr  X:39,711,001...39,953,860
Ensembl chr  X:39,711,201...39,951,847 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance
increases activity
decreases response to substance
multiple interactions		 ISO CNR1 gene polymorphism affects the susceptibility to Cocaine; CNR1 gene SNP affects the susceptibility to Cocaine; CNR1 polymorphism affects the susceptibility to Cocaine
Cocaine results in increased activity of CNR1 protein
CNR1 mutant form results in decreased susceptibility to Cocaine
CNR1 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of PPP1R1B protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased expression of FOS protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CNR1 mutant form inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:9106242 PMID:16314880 PMID:17596442 PMID:19052543 PMID:20554863 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression ISO Cocaine results in increased expression of CNR2 mRNA CTD PMID:18286196 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126 		JBrowse link
G Cobll1 cordon-bleu WH2 repeat protein-like 1 increases expression ISO Cocaine results in increased expression of COBLL1 mRNA CTD PMID:27506785 NCBI chr 3:51,137,104...51,298,956
Ensembl chr 3:51,137,076...51,297,852 		JBrowse link
G Coil coilin affects expression EXP Cocaine affects the expression of COIL mRNA CTD PMID:20187946 NCBI chr10:76,320,676...76,336,169
Ensembl chr10:76,320,041...76,341,418 		JBrowse link
G Col15a1 collagen type XV alpha 1 chain affects expression EXP Cocaine affects the expression of COL15A1 mRNA CTD PMID:20187946 NCBI chr 5:62,840,360...62,950,240
Ensembl chr 5:64,476,317...64,542,645
Ensembl chr 5:64,476,317...64,542,645 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression EXP Cocaine results in increased expression of COL1A1 mRNA CTD PMID:9455993 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression EXP Cocaine results in increased expression of COL3A1 mRNA CTD PMID:9455993 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217 		JBrowse link
G Coq6 coenzyme Q6 monooxygenase affects expression EXP Cocaine affects the expression of COQ6 mRNA CTD PMID:20187946 NCBI chr 6:108,076,393...108,087,782
Ensembl chr 6:108,076,306...108,087,696 		JBrowse link
G Coro7 coronin 7 multiple interactions ISO [Cocaine co-treated with FOS protein mutant form] results in decreased expression of CORO7 mRNA CTD PMID:18355967 NCBI chr10:11,090,200...11,144,289
Ensembl chr10:11,090,314...11,143,881
Ensembl chr10:11,090,314...11,143,881 		JBrowse link
G Cox20 cytochrome c oxidase assembly factor COX20 decreases expression EXP Cocaine results in decreased expression of COX20 mRNA CTD PMID:17898221 NCBI chr13:96,219,853...96,224,023
Ensembl chr13:96,219,853...96,224,023 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A affects expression EXP Cocaine affects the expression of COX5A mRNA CTD PMID:20187946 NCBI chr 8:62,298,358...62,309,765
Ensembl chr 8:62,298,358...62,309,765 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 affects expression
increases expression		 EXP Cocaine affects the expression of COX6A1 mRNA
Cocaine results in increased expression of COX6A1 protein		 CTD PMID:20187946 PMID:25100957 NCBI chr12:47,024,442...47,027,495
Ensembl chr12:47,024,442...47,027,495 		JBrowse link
G Cox6c cytochrome c oxidase subunit 6C decreases expression ISO Cocaine results in decreased expression of COX6C mRNA CTD PMID:12629581 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650 		JBrowse link
G Cox7b cytochrome c oxidase subunit 7B affects expression EXP Cocaine affects the expression of COX7B mRNA CTD PMID:20187946 NCBI chr  X:77,065,427...77,071,676
Ensembl chr  X:77,065,397...77,071,676 		JBrowse link
G Cox8a cytochrome c oxidase subunit 8A affects expression EXP Cocaine affects the expression of COX8A mRNA CTD PMID:20187946 NCBI chr 1:222,466,575...222,468,896
Ensembl chr 1:222,466,575...222,468,896 		JBrowse link
G Cplx1 complexin 1 affects expression EXP Cocaine affects the expression of CPLX1 mRNA CTD PMID:20187946 NCBI chr14:2,194,895...2,226,610
Ensembl chr14:2,194,933...2,226,598 		JBrowse link
G Cpne8 copine 8 increases expression EXP Cocaine results in increased expression of CPNE8 mRNA CTD PMID:17898221 NCBI chr 7:131,623,180...131,798,236
Ensembl chr 7:131,623,181...131,798,236 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 affects expression
increases phosphorylation
multiple interactions
affects phosphorylation
increases expression		 EXP
ISO		 Cocaine affects the expression of CREB1 mRNA
Cocaine results in increased phosphorylation of CREB1 protein
CDK5R1 protein inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; Cocaine inhibits the reaction [CREB1 protein binds to BDNF promoter]; N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine inhibits the reaction [Cocaine results in increased expression of CREB1 protein]; RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]; SL 327 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]
Cocaine affects the phosphorylation of CREB1 protein
Betaxolol affects the reaction [Cocaine affects the phosphorylation of CREB1 protein]; Cocaine affects the reaction [CREB1 modified form binds to BDNF promoter]; Cocaine promotes the reaction [RPS6KA1 protein binds to CREB1 protein]; Cocaine results in increased phosphorylation of and results in increased activity of CREB1 protein; U 0126 inhibits the reaction [Cocaine results in increased phosphorylation of CREB1 protein]		 CTD PMID:12595601 PMID:15470197 PMID:15665076 PMID:16219028 PMID:16339038 PMID:16710312 PMID:18596687 PMID:20187946 PMID:20810894 PMID:24358339 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crebbp CREB binding protein increases expression EXP Cocaine results in increased expression of CREBBP mRNA CTD PMID:17898221 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039 		JBrowse link
G Crebrf CREB3 regulatory factor increases expression EXP Cocaine results in increased expression of CREBRF mRNA CTD PMID:17898221 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205 		JBrowse link
G Crem cAMP responsive element modulator affects expression
increases expression		 ISO
EXP		 Cocaine affects the expression of CREM mRNA
Cocaine results in increased expression of CREM mRNA		 CTD PMID:18355967 PMID:27899881 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions
affects expression		 EXP Betaxolol affects the reaction [Cocaine affects the expression of CRH mRNA]; Cocaine affects the reaction [CRH protein affects the secretion of Excitatory Amino Acid Agents]; SCH 23390 affects the reaction [Cocaine affects the expression of CRH mRNA]
Cocaine affects the expression of CRH mRNA; Cocaine affects the expression of CRH protein		 CTD PMID:7796157 PMID:11597771 PMID:12782395 PMID:15930388 PMID:18596687 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein increases expression EXP Cocaine results in increased expression of CRHBP mRNA CTD PMID:27899881 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 increases expression EXP Cocaine results in increased expression of CRHR1 protein CTD PMID:17079348 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645 		JBrowse link
G Crip2 cysteine-rich protein 2 affects expression EXP Cocaine affects the expression of CRIP2 mRNA CTD PMID:20187946 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490 		JBrowse link
G Crispld1 cysteine-rich secretory protein LCCL domain containing 1 decreases expression EXP Cocaine results in decreased expression of CRISPLD1 mRNA CTD PMID:27899881 NCBI chr 5:663,750...711,033
Ensembl chr 5:670,754...711,033 		JBrowse link
G Crp C-reactive protein increases expression ISO Cocaine results in increased expression of CRP protein CTD PMID:11988210 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Crtac1 cartilage acidic protein 1 affects expression EXP Cocaine affects the expression of CRTAC1 mRNA CTD PMID:20187946 NCBI chr 1:261,527,009...261,669,614
Ensembl chr 1:261,514,141...261,669,586 		JBrowse link
G Crtc1 CREB regulated transcription coactivator 1 multiple interactions EXP [[Cocaine results in increased expression of MIR212 mRNA] which results in increased activity of RAF1 protein] which results in increased expression of CRTC1 protein CTD PMID:20613834 NCBI chr16:20,740,746...20,798,145
Ensembl chr16:20,740,826...20,794,039 		JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Cocaine results in decreased expression of CRY1 mRNA CTD PMID:15994025 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression ISO Cocaine results in decreased expression of CRY2 mRNA CTD PMID:15994025 NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110 		JBrowse link
G Cryab crystallin, alpha B decreases expression
increases expression		 ISO
EXP		 Cocaine results in decreased expression of CRYAB mRNA
Cocaine results in increased expression of CRYAB mRNA		 CTD PMID:15009677 PMID:27899881 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Crybb2 crystallin, beta B2 decreases expression ISO Cocaine results in decreased expression of CRYBB2 mRNA CTD PMID:15009677 NCBI chr12:49,577,580...49,588,555
Ensembl chr12:49,578,633...49,588,555 		JBrowse link
G Csad cysteine sulfinic acid decarboxylase affects expression
decreases expression		 EXP Cocaine affects the expression of CSAD mRNA
Cocaine results in decreased expression of CSAD protein		 CTD PMID:20187946 PMID:25100957 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970 		JBrowse link
G Csf2ra colony stimulating factor 2 receptor subunit alpha decreases expression EXP Cocaine results in decreased expression of CSF2RA mRNA CTD PMID:17898221 NCBI chr14:1,462,292...1,467,264
Ensembl chr14:1,462,358...1,467,264 		JBrowse link
G Csn3 casein kappa affects expression EXP Cocaine affects the expression of CSN3 mRNA CTD PMID:20187946 NCBI chr14:21,803,738...21,810,291
Ensembl chr14:21,803,735...21,810,314 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression EXP Cocaine results in decreased expression of CSNK2A1 mRNA CTD PMID:12117546 NCBI chr 3:147,713,808...147,760,375
Ensembl chr 3:147,713,821...147,757,862 		JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 affects expression EXP Cocaine affects the expression of CSPG5 mRNA; Cocaine affects the expression of CSPG5 protein CTD PMID:12358776 NCBI chr 8:118,333,695...118,348,040
Ensembl chr 8:118,333,706...118,347,582 		JBrowse link
G Csrp2 cysteine and glycine-rich protein 2 decreases expression ISO Cocaine results in decreased expression of CSRP2 mRNA CTD PMID:18000554 NCBI chr 7:53,630,675...53,649,309
Ensembl chr 7:53,630,621...53,649,310 		JBrowse link
G Ctdnep1 CTD nuclear envelope phosphatase 1 affects expression EXP Cocaine affects the expression of CTDNEP1 mRNA CTD PMID:20187946 NCBI chr10:56,590,822...56,600,235
Ensembl chr10:56,591,292...56,600,232 		JBrowse link
G Ctnnb1 catenin beta 1 affects expression
multiple interactions		 EXP Cocaine affects the expression of CTNNB1 mRNA
Cocaine deficiency promotes the reaction [SMARCA4 protein binds to CTNNB1 promoter]		 CTD PMID:20187946 PMID:27422367 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 decreases expression ISO Cocaine results in decreased expression of CTNNBIP1 mRNA CTD PMID:18000554 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027 		JBrowse link
G Ctnnd2 catenin delta 2 decreases expression
increases expression		 ISO
EXP		 Cocaine results in decreased expression of CTNND2 mRNA
Cocaine results in increased expression of CTNND2 mRNA		 CTD PMID:12629581 PMID:16076954 NCBI chr 2:83,227,247...84,094,315
Ensembl chr 2:83,393,282...84,094,315 		JBrowse link
G Ctrl chymotrypsin-like affects expression
increases expression		 EXP Cocaine affects the expression of CTRL mRNA
Cocaine results in increased expression of CTRL mRNA		 CTD PMID:20187946 PMID:27899881 NCBI chr19:37,905,864...37,907,714
Ensembl chr19:37,905,864...37,907,714 		JBrowse link
G Ctsb cathepsin B affects expression
multiple interactions
increases expression		 ISO Cocaine affects the expression of CTSB mRNA
FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of CTSB mRNA]		 CTD PMID:15681117 PMID:18355967 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612 		JBrowse link
G Ctsd cathepsin D affects expression
increases expression		 ISO
EXP		 Cocaine affects the expression of CTSD mRNA
Cocaine results in increased expression of CTSD protein		 CTD PMID:15681117 PMID:25100957 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451 		JBrowse link
G Cuedc1 CUE domain containing 1 multiple interactions ISO HDAC5 affects the reaction [Cocaine affects the expression of CUEDC1 mRNA] CTD PMID:17988634 NCBI chr10:75,495,817...75,516,280
Ensembl chr10:75,495,817...75,516,304 		JBrowse link
G Cul4b cullin 4B increases expression ISO Cocaine results in increased expression of CUL4B mRNA CTD PMID:15009677 NCBI chr  X:124,831,391...124,870,329
Ensembl chr  X:124,832,628...124,870,329 		JBrowse link
G Cwf19l2 CWF19 like cell cycle control factor 2 increases expression EXP Cocaine results in increased expression of CWF19L2 mRNA CTD