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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:potassium channel modulator
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Accession:CHEBI:50510 term browser browse the term

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2-aminoethoxydiphenylborane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased expression of BAX protein] CTD PMID:29883672 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein] CTD PMID:29883672 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased cleavage of CASP12 protein] CTD PMID:29883672 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein] CTD PMID:29883672 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Cd28 CD28 antigen multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Calcium]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:14607919 NCBI chr 1:60,746,388...60,773,359
Ensembl chr 1:60,716,800...60,773,359 		JBrowse link
G Grm1 glutamate receptor, metabotropic 1 multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] CTD PMID:14622174 NCBI chr10:10,686,059...11,082,382
Ensembl chr10:10,686,059...11,082,356 		JBrowse link
4-aminopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 9430015G10Rik RIKEN cDNA 9430015G10 gene increases expression ISO 4-Aminopyridine results in increased expression of C1ORF159 mRNA CTD PMID:24378259 NCBI chr 4:156,109,998...156,127,265
Ensembl chr 4:156,109,982...156,127,265 		JBrowse link
G Adra1b adrenergic receptor, alpha 1b multiple interactions ISO 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] CTD PMID:18480251 NCBI chr11:43,774,605...43,901,250
Ensembl chr11:43,774,606...43,901,210 		JBrowse link
G Bax BCL2-associated X protein increases expression ISO 4-Aminopyridine results in increased expression of BAX mRNA CTD PMID:24378259 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO 4-Aminopyridine results in decreased expression of BIRC2 mRNA CTD PMID:24378259 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 4-Aminopyridine results in decreased expression of BIRC3 mRNA CTD PMID:24378259 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186 		JBrowse link
G Bmf BCL2 modifying factor increases expression ISO 4-Aminopyridine results in increased expression of BMF mRNA CTD PMID:24378259 NCBI chr 2:118,528,757...118,549,686
Ensembl chr 2:118,528,757...118,549,687 		JBrowse link
G Casp3 caspase 3 increases activity ISO 4-Aminopyridine results in increased activity of CASP3 protein CTD PMID:24378259 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp7 caspase 7 increases activity ISO 4-Aminopyridine results in increased activity of CASP7 protein CTD PMID:24378259 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344 		JBrowse link
G Casp9 caspase 9 increases activity ISO 4-Aminopyridine results in increased activity of CASP9 protein CTD PMID:24378259 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cd40 CD40 antigen increases expression ISO 4-Aminopyridine results in increased expression of CD40 mRNA CTD PMID:24378259 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948 		JBrowse link
G Cd40lg CD40 ligand increases expression ISO 4-Aminopyridine results in increased expression of CD40LG mRNA CTD PMID:24378259 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042 		JBrowse link
G Ctsb cathepsin B increases expression ISO 4-Aminopyridine results in increased expression of CTSB mRNA CTD PMID:24378259 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923 		JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO 4-Aminopyridine results in increased expression of DPYSL4 mRNA CTD PMID:24378259 NCBI chr 7:139,085,981...139,101,795
Ensembl chr 7:139,086,001...139,102,704 		JBrowse link
G Gad2 glutamic acid decarboxylase 2 increases expression
multiple interactions		 ISO 4-Aminopyridine results in increased expression of GAD2 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]		 CTD PMID:25917026 NCBI chr 2:22,621,015...22,693,877
Ensembl chr 2:22,622,205...22,693,874 		JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 decreases expression ISO 4-Aminopyridine results in decreased expression of GALNT5 mRNA CTD PMID:24378259 NCBI chr 2:57,997,850...58,041,027
Ensembl chr 2:57,997,884...58,045,860 		JBrowse link
G Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein CTD PMID:19911010 NCBI chr 7:45,831,883...45,871,194
Ensembl chr 7:45,831,883...45,878,378 		JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein CTD PMID:15773917 NCBI chr11:102,195,747...102,230,172
Ensembl chr11:102,194,432...102,230,166 		JBrowse link
G Jph3 junctophilin 3 increases expression ISO 4-Aminopyridine results in increased expression of JPH3 mRNA CTD PMID:24378259 NCBI chr 8:121,730,559...121,791,083
Ensembl chr 8:121,729,623...121,794,276 		JBrowse link
G Kcna10 potassium voltage-gated channel, shaker-related subfamily, member 10 multiple interactions ISO 4-Aminopyridine inhibits the reaction [KCNA10 protein results in increased transport of Potassium] CTD PMID:10836990 NCBI chr 3:107,183,143...107,195,721
Ensembl chr 3:107,183,056...107,195,721 		JBrowse link
G Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 increases expression
multiple interactions		 ISO 4-Aminopyridine results in increased expression of KCND3 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]		 CTD PMID:25917026 NCBI chr 3:105,451,890...105,674,002
Ensembl chr 3:105,452,330...105,674,002 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO 4-Aminopyridine results in decreased activity of KCNH2 protein CTD PMID:19915712 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Kcnip1 Kv channel-interacting protein 1 decreases expression
increases expression
multiple interactions		 ISO 4-Aminopyridine results in decreased expression of KCNIP1 mRNA
4-Aminopyridine results in increased expression of KCNIP1 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]		 CTD PMID:24378259 PMID:25917026 NCBI chr11:33,629,339...33,993,348
Ensembl chr11:33,629,339...33,993,152 		JBrowse link
G Mag myelin-associated glycoprotein decreases expression ISO 4-Aminopyridine results in decreased expression of MAG mRNA CTD PMID:24378259 NCBI chr 7:30,899,175...30,914,922
Ensembl chr 7:30,899,176...30,914,873 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO 4-Aminopyridine results in increased expression of MAP1LC3A mRNA CTD PMID:24378259 NCBI chr 2:155,276,364...155,278,073
Ensembl chr 2:155,276,297...155,278,073 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
4-Aminopyridine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19911010 PMID:22759588 PMID:28132918 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
4-Aminopyridine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19911010 PMID:22759588 PMID:28132918 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] CTD PMID:15773917 NCBI chr 5:125,017,153...125,179,238
Ensembl chr 5:125,017,153...125,179,219 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942 		JBrowse link
G S100a7a S100 calcium binding protein A7A decreases expression ISO 4-Aminopyridine results in decreased expression of S100A7A mRNA CTD PMID:24378259 NCBI chr 3:90,651,925...90,658,130
Ensembl chr 3:90,654,017...90,658,669 		JBrowse link
G Syn1 synapsin I affects response to substance
increases response to substance
increases expression
multiple interactions		 EXP
ISO		 SYN1 protein affects the susceptibility to 4-Aminopyridine
SYN1 results in increased susceptibility to 4-Aminopyridine
4-Aminopyridine results in increased expression of SYN1 protein modified form
ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]		 CTD PMID:22759588 PMID:28132918 NCBI chr  X:20,860,511...20,920,918
Ensembl chr  X:20,860,511...20,921,004 		JBrowse link
G Traf2 TNF receptor-associated factor 2 increases expression ISO 4-Aminopyridine results in increased expression of TRAF2 mRNA CTD PMID:24378259 NCBI chr 2:25,517,982...25,546,940
Ensembl chr 2:25,517,982...25,546,940 		JBrowse link
barium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO [barium chloride results in increased abundance of Barium] which results in decreased activity of ACHE protein CTD PMID:31407482 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466 		JBrowse link
G Alb albumin multiple interactions
increases secretion		 ISO Plant Extracts inhibits the reaction [barium chloride results in increased secretion of ALB protein] CTD PMID:26732703 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602 		JBrowse link
G Cat catalase multiple interactions
decreases activity		 ISO [barium chloride results in increased abundance of Barium] which results in decreased activity of CAT protein; Plant Extracts inhibits the reaction [barium chloride results in decreased activity of CAT protein] CTD PMID:26732703 PMID:31407482 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO barium chloride results in increased expression of IL1B mRNA
Plant Extracts inhibits the reaction [barium chloride results in increased expression of IL1B mRNA]		 CTD PMID:26732703 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO barium chloride results in increased expression of IL6 mRNA
[barium chloride results in increased abundance of Barium] which results in increased expression of IL6 protein; Plant Extracts inhibits the reaction [barium chloride results in increased expression of IL6 mRNA]		 CTD PMID:26732703 PMID:31407482 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 multiple interactions ISO barium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] CTD PMID:16909339 NCBI chr16:92,346,001...92,359,468
Ensembl chr16:92,345,982...92,359,468 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 multiple interactions ISO barium chloride inhibits the reaction [KCNJ2 protein results in increased transport of Potassium] CTD PMID:11087224 NCBI chr11:111,066,164...111,076,825
Ensembl chr11:111,066,164...111,076,821 		JBrowse link
G Kcnk3 potassium channel, subfamily K, member 3 decreases activity ISO barium chloride results in decreased activity of KCNK3 protein CTD PMID:16020457 NCBI chr 5:30,588,170...30,625,270
Ensembl chr 5:30,588,170...30,625,271 		JBrowse link
G Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 multiple interactions ISO barium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] CTD PMID:16909339 NCBI chr 7:143,106,877...143,427,050
Ensembl chr 7:143,106,362...143,427,042 		JBrowse link
G Mt1 metallothionein 1 increases expression
multiple interactions		 ISO barium chloride results in increased expression of MT1 mRNA
Plant Extracts inhibits the reaction [barium chloride results in increased expression of MT1 mRNA]		 CTD PMID:26732703 NCBI chr 8:94,178,883...94,180,327
Ensembl chr 8:94,179,082...94,180,327 		JBrowse link
G Mt2 metallothionein 2 increases expression
multiple interactions		 ISO barium chloride results in increased expression of MT2A mRNA
Plant Extracts inhibits the reaction [barium chloride results in increased expression of MT2A mRNA]		 CTD PMID:26732703 NCBI chr 8:94,172,618...94,173,567
Ensembl chr 8:94,172,664...94,173,568 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 increases secretion ISO barium chloride results in increased secretion of SERPINE1 protein CTD PMID:21596853 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases expression
multiple interactions		 ISO barium chloride results in decreased expression of SOD2 mRNA
Plant Extracts inhibits the reaction [barium chloride results in decreased expression of SOD2 mRNA]		 CTD PMID:26732703 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Stx1a syntaxin 1A (brain) affects localization
multiple interactions		 ISO barium chloride affects the localization of STX1A protein
Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]]		 CTD PMID:29320738 NCBI chr 5:135,023,482...135,051,100
Ensembl chr 5:135,023,482...135,051,100 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO Plant Extracts inhibits the reaction [barium chloride results in increased expression of TNF mRNA] CTD PMID:26732703 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Tsc22d3 TSC22 domain family, member 3 multiple interactions EXP [barium chloride results in increased abundance of Barium] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:29957541 NCBI chr  X:140,539,528...140,600,522
Ensembl chr  X:140,539,528...140,600,659 		JBrowse link
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B increases expression ISO Berberine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632 		JBrowse link
G Acan aggrecan decreases expression ISO Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr 7:79,053,226...79,115,099
Ensembl chr 7:79,053,483...79,115,099 		JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA] CTD PMID:29170048 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr11:116,171,883...116,199,045
Ensembl chr11:116,171,888...116,199,045 		JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta decreases expression ISO Berberine results in decreased expression of ACTA2 protein CTD PMID:17973934 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028 		JBrowse link
G Ahr aryl-hydrocarbon receptor increases activity ISO Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
increases phosphorylation		 ISO Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein		 CTD PMID:23954465 PMID:30138605 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826 		JBrowse link
G Alb albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602 		JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664 		JBrowse link
G Aurkc aurora kinase C increases expression ISO Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr 7:6,995,347...7,003,091
Ensembl chr 7:6,995,300...7,003,091 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 ISO [Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Niacinamide] results in increased expression of BAX protein; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]		 CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
multiple interactions		 ISO Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA		 CTD PMID:26712469 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
increases expression
multiple interactions		 ISO Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]		 CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728 		JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) multiple interactions
increases expression		 ISO [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA		 CTD PMID:26712469 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547 		JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression
multiple interactions		 ISO Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]		 CTD PMID:26478571 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression		 ISO [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA		 CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp8 caspase 8 increases activity ISO Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO Berberine results in increased cleavage of CASP9 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein		 CTD PMID:16505103 PMID:26712469 PMID:30138605 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein] CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] CTD PMID:16391493 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Berberine results in decreased expression of CCND1 protein CTD PMID:16505103 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr 7:38,097,984...38,107,490
Ensembl chr 7:38,097,984...38,107,534 		JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr15:98,538,690...98,567,736
Ensembl chr15:98,538,689...98,570,923 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein		 CTD PMID:28038998 PMID:29408570 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246 		JBrowse link
G Cdk2 cyclin-dependent kinase 2 decreases expression ISO Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Berberine results in decreased expression of CDK4 protein CTD PMID:16505103 NCBI chr10:127,063,535...127,067,288
Ensembl chr10:127,063,534...127,067,920 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 5:3,341,004...3,531,008
Ensembl chr 5:3,341,485...3,531,008 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 2:32,705,782...32,712,784
Ensembl chr 2:32,705,784...32,713,076 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) increases expression ISO Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr 7:143,458,339...143,461,059
Ensembl chr 7:143,458,339...143,461,050 		JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions
decreases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA		 CTD PMID:20564506 PMID:26478571 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928 		JBrowse link
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta affects phosphorylation
increases expression
multiple interactions		 EXP
ISO		 Berberine affects the phosphorylation of CEBPB protein
Berberine results in increased expression of CEBPB mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]		 CTD PMID:28038998 NCBI chr 2:167,688,915...167,690,432
Ensembl chr 2:167,688,915...167,690,418 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145 		JBrowse link
G Col10a1 collagen, type X, alpha 1 increases expression ISO Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr10:34,389,981...34,397,085
Ensembl chr10:34,389,981...34,397,085 		JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression ISO Berberine results in increased expression of COL1A1 mRNA CTD PMID:26478571 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042 		JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:4,081,334...4,213,957
Ensembl chr16:4,081,328...4,213,997 		JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]		 CTD PMID:26478571 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493 PMID:28916288 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Berberine affects the localization of CYCS protein CTD PMID:16505103 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr19:46,667,165...46,673,000
Ensembl chr19:46,667,165...46,673,172 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]		 CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA		 CTD PMID:22342832 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624 		JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 multiple interactions
increases expression		 EXP Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B9 mRNA]; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]
Berberine results in increased expression of CYP2B9 mRNA		 CTD PMID:22342832 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions		 EXP Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]		 CTD PMID:22342832 PMID:25455889 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
decreases expression		 EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP3A11 mRNA]
Berberine results in decreased expression of CYP3A11 mRNA		 CTD PMID:22342832 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions
decreases expression		 EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A10 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A10 mRNA]
Berberine results in decreased expression of CYP4A10 mRNA		 CTD PMID:22342832 NCBI chr 4:115,518,287...115,533,649
Ensembl chr 4:115,518,264...115,533,649 		JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
decreases expression		 EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A14 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A14 mRNA]
Berberine results in decreased expression of CYP4A14 mRNA		 CTD PMID:22342832 NCBI chr 4:115,486,200...115,496,158
Ensembl chr 4:115,486,200...115,496,142 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr19:30,545,876...30,549,496
Ensembl chr19:30,545,863...30,549,665 		JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases expression ISO Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888 		JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression ISO Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730 		JBrowse link
G Dzip3 DAZ interacting protein 3, zinc finger increases expression ISO Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr16:48,924,228...48,994,142
Ensembl chr16:48,924,232...48,994,165 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674 		JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,910,977...6,922,048
Ensembl chr19:6,910,977...6,921,813
Ensembl chr19:6,910,977...6,921,813 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression
increases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]		 CTD PMID:26478571 PMID:29408570 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576 		JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
increases expression		 EXP
ISO		 [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein		 CTD PMID:20564506 PMID:20656010 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772 		JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) increases expression ISO Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA] CTD PMID:30138605 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755 		JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr 2:155,941,023...155,945,367
Ensembl chr 2:155,941,023...155,945,367 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP
ISO		 Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]		 CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 EXP
ISO		 Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]		 CTD PMID:20462044 PMID:23954465 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163 		JBrowse link
G H2ac10 H2A clustered histone 10 decreases expression ISO Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr13:23,533,875...23,534,378
Ensembl chr13:23,533,906...23,534,304 		JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr13:22,035,122...22,035,643
Ensembl chr13:22,035,164...22,035,568 		JBrowse link
G H2ac13 H2A clustered histone 13 decreases expression ISO Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr13:21,716,412...21,716,859
Ensembl chr13:21,716,422...21,716,814 		JBrowse link
G H2ac18 H2A clustered histone 18 decreases expression ISO Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 3:96,245,497...96,246,052
Ensembl chr 3:96,245,497...96,246,082 		JBrowse link
G H2ac22 H2A clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr13:21,786,774...21,787,248
Ensembl chr13:21,786,826...21,787,218 		JBrowse link
G H2ac4 H2A clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr13:23,751,088...23,751,592
Ensembl chr13:23,751,126...23,751,598 		JBrowse link
G H2ac6 H2A clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr13:23,683,473...23,683,959
Ensembl chr13:23,681,467...23,683,948 		JBrowse link
G H2ac7 H2A clustered histone 7 decreases expression ISO Berberine results in decreased expression of H2AC17 mRNA CTD PMID:27311644 NCBI chr13:23,574,381...23,574,915
Ensembl chr13:23,574,381...23,574,952 		JBrowse link
G H2aw H2A.W histone decreases expression ISO Berberine results in decreased expression of H2AW mRNA CTD PMID:27311644 NCBI chr11:58,954,685...58,955,192
Ensembl chr11:58,954,685...58,956,830 		JBrowse link
G H2ax H2A.X variant histone increases expression
decreases expression
multiple interactions		 ISO Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]		 CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077 		JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr13:22,035,821...22,036,320
Ensembl chr13:22,035,870...22,036,345 		JBrowse link
G H2bc14 H2B clustered histone 14 decreases expression ISO Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr13:21,722,044...21,722,526
Ensembl chr13:21,722,044...21,722,567 		JBrowse link
G H2bc15 H2B clustered histone 15 decreases expression ISO Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr13:21,754,076...21,754,553
Ensembl chr13:21,754,123...21,754,503 		JBrowse link
G H2bc21 H2B clustered histone 21 decreases expression ISO Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 3:96,221,072...96,223,738
Ensembl chr 3:96,221,119...96,223,738 		JBrowse link
G H2bc22 H2B clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr13:21,787,483...21,801,561
Ensembl chr13:21,787,461...21,789,213 		JBrowse link
G H2bc4 H2B clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr13:23,684,199...23,692,480
Ensembl chr13:23,684,199...23,692,908 		JBrowse link
G H2bc6 H2B clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr13:23,583,670...23,621,124
Ensembl chr13:23,583,670...23,621,124 		JBrowse link
G H2bc7 H2B clustered histone 7 decreases expression ISO Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr13:23,573,760...23,574,207
Ensembl chr13:23,573,736...23,574,196 		JBrowse link
G H2bc8 H2B clustered histone 8 decreases expression ISO Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr13:23,571,400...23,571,863
Ensembl chr13:23,571,396...23,572,013 		JBrowse link
G H2bw2 H2B.W histone 2 decreases expression ISO Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:136,927,325...136,928,373
Ensembl chr  X:136,927,325...136,928,376 		JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Berberine results in decreased expression of H3C10 mRNA CTD PMID:27311644 NCBI chr13:23,761,885...23,762,386
Ensembl chr13:23,761,853...23,762,386 		JBrowse link
G H3c11 H3 clustered histone 11 decreases expression ISO Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr13:21,782,915...21,783,397
Ensembl chr13:21,782,960...21,783,370 		JBrowse link
G H3c8 H3 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr13:23,535,418...23,535,909
Ensembl chr13:23,535,422...23,535,951 		JBrowse link
G H3f3a H3.3 histone A decreases expression ISO Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:180,802,560...180,813,605
Ensembl chr 1:180,800,832...180,813,943 		JBrowse link
G H3f4 H3.4 histone decreases expression ISO Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr11:58,961,711...58,962,273
Ensembl chr11:58,961,812...58,962,222 		JBrowse link
G H4c12 H4 clustered histone 12 decreases expression ISO Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr13:21,750,145...21,750,553
Ensembl chr13:21,750,194...21,750,505 		JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr 3:96,262,934...96,263,317
Ensembl chr 3:96,261,682...96,263,311 		JBrowse link
G H4c3 H4 clustered histone 3 decreases expression ISO Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr13:23,698,084...23,698,458
Ensembl chr13:23,697,635...23,698,454 		JBrowse link
G H4c8 H4 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr13:23,531,044...23,531,478
Ensembl chr13:23,531,050...23,531,519 		JBrowse link
G Hat1 histone aminotransferase 1 increases expression ISO Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:71,389,260...71,441,622
Ensembl chr 2:71,388,958...71,441,622 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889 		JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr11:102,195,747...102,230,172
Ensembl chr11:102,194,432...102,230,166 		JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:102,284,638...102,505,381
Ensembl chr  X:102,284,639...102,505,359 		JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
increases expression		 ISO Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA		 CTD PMID:27311644 NCBI chr12:34,047,580...34,917,095
Ensembl chr12:34,047,580...34,917,095 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein		 CTD PMID:29408570 NCBI chr 5:16,553,495...16,619,439
Ensembl chr 5:16,553,495...16,620,152 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of HMOX1 protein
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]		 CTD PMID:23954465 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha multiple interactions ISO
EXP		 Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]		 CTD PMID:18563319 PMID:25455889 NCBI chr 2:163,506,811...163,572,907
Ensembl chr 2:163,506,808...163,572,910 		JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha decreases expression ISO Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 9:54,586,511...54,604,662
Ensembl chr 9:54,586,334...54,604,661 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892 		JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein		 CTD PMID:23954465 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 EXP
ISO		 Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA		 CTD PMID:21867779 PMID:30138605 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]		 CTD PMID:16391493 PMID:29170048 PMID:30138605 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il2 interleukin 2 increases expression EXP Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr10:128,296,140...128,298,084
Ensembl chr10:128,296,139...128,298,752 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA		 CTD PMID:21867779 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]
Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]		 CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Itga1 integrin alpha 1 increases expression ISO Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr13:114,958,079...115,101,964
Ensembl chr13:114,953,096...115,101,964 		JBrowse link
G Jun jun proto-oncogene affects localization
multiple interactions		 ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]		 CTD PMID:18294404 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions		 ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]		 CTD PMID:30086269 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A increases expression ISO Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 4:136,550,533...136,602,787
Ensembl chr 4:136,550,540...136,602,723 		JBrowse link
G Kdm4a lysine (K)-specific demethylase 4A increases expression ISO Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 4:118,136,957...118,180,090
Ensembl chr 4:118,136,957...118,180,043 		JBrowse link
G Kdm5b lysine (K)-specific demethylase 5B increases expression ISO Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:134,560,178...134,632,878
Ensembl chr 1:134,560,171...134,635,285 		JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A increases expression ISO Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:18,160,862...18,279,936
Ensembl chr  X:18,162,575...18,279,936 		JBrowse link
G Kdm6b KDM1 lysine (K)-specific demethylase 6B increases expression ISO Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr11:69,398,508...69,420,367
Ensembl chr11:69,398,508...69,413,675 		JBrowse link
G Kmt5a lysine methyltransferase 5A increases expression ISO Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr 5:124,439,930...124,462,311
Ensembl chr 5:124,439,930...124,462,308 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]		 CTD PMID:18640378 PMID:20564506 NCBI chr 9:21,723,576...21,749,919
Ensembl chr 9:21,723,483...21,749,919 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]		 CTD PMID:18294404 PMID:20462044 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780 		JBrowse link
G Mir19a microRNA 19a decreases expression ISO Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr14:115,044,000...115,044,081
Ensembl chr14:115,044,000...115,044,081 		JBrowse link
G Mir92-1 microRNA 92-1 decreases expression ISO Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr14:115,044,427...115,044,506
Ensembl chr14:115,044,427...115,044,506 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions
decreases expression		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:54,431,598...54,442,456
Ensembl chr14:54,431,612...54,445,364 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]		 CTD PMID:18294404 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 3:138,089,855...138,143,418
Ensembl chr 3:138,089,854...138,144,968 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
affects localization		 ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression		 ISO [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr12:32,820,335...32,853,369
Ensembl chr12:32,819,545...32,853,349 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
increases activity
multiple interactions		 ISO Berberine results in increased expression of NFE2L2 protein
Berberine results in increased activity of NFE2L2 protein
Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]		 CTD PMID:23523906 PMID:23954465 PMID:30818834 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:21963898 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 3:102,469,919...102,521,013
Ensembl chr 3:102,469,919...102,521,013 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]		 CTD PMID:21095217 PMID:23523906 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver] RGD PMID:31432116 RGD:25823187 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:21524698 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 decreases expression ISO Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 5:33,820,676...33,897,966
Ensembl chr 5:33,820,725...33,897,975 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions
decreases expression		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr12:17,544,808...17,551,502
Ensembl chr12:17,544,794...17,551,505 		JBrowse link
G Omd osteomodulin increases expression ISO Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr13:49,582,462...49,592,612
Ensembl chr13:49,582,462...49,592,822 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions ISO Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions		 ISO Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein		 CTD PMID:16505103 PMID:26712469 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases response to substance
increases expression
decreases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
PPARG mRNA results in increased susceptibility to Berberine
Berberine results in increased expression of PPARG mRNA
Berberine results in decreased expression of PPARG mRNA		 CTD PMID:20564506 PMID:26478571 PMID:29408570 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726 		JBrowse link
G Prg4 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) decreases expression ISO Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:150,449,412...150,466,221
Ensembl chr 1:150,449,412...150,466,165 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation EXP Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr15:5,143,861...5,181,899
Ensembl chr15:5,143,861...5,181,899 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases activity		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919 		JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases expression ISO Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr 7:44,976,755...44,986,420
Ensembl chr 7:44,975,989...44,986,568 		JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 increases expression ISO Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr10:76,207,226...76,237,865
Ensembl chr10:76,207,222...76,237,865 		JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 increases expression ISO Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:54,507,182...54,517,470
Ensembl chr14:54,507,187...54,517,525 		JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 increases expression ISO Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 3:110,246,104...110,250,999
Ensembl chr 3:110,246,109...110,250,998 		JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 increases expression ISO Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr 8:106,211,054...106,251,694
Ensembl chr 8:106,210,936...106,252,794 		JBrowse link
G Prmt8 protein arginine N-methyltransferase 8 increases expression ISO Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr 6:127,689,009...127,769,467
Ensembl chr 6:127,689,011...127,769,472 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 EXP Berberine results in increased expression of PTEN protein
((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]		 CTD PMID:29408570 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Rbp4 retinol binding protein 4, plasma multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr19:38,116,620...38,125,321
Ensembl chr19:38,116,629...38,125,281 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein] CTD PMID:23523906 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G Rln1 relaxin 1 affects binding
increases expression
multiple interactions		 ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA		 CTD PMID:22363579 NCBI chr19:29,331,755...29,334,670
Ensembl chr19:29,331,170...29,334,670 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412 		JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions
increases expression		 ISO CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797 		JBrowse link
G Setd1b SET domain containing 1B increases expression ISO Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr 5:123,142,040...123,168,630
Ensembl chr 5:123,142,193...123,168,629 		JBrowse link
G Setd2 SET domain containing 2 increases expression ISO Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 9:110,532,500...110,618,633
Ensembl chr 9:110,532,597...110,618,633 		JBrowse link
G Setd3 SET domain containing 3 increases expression ISO Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr12:108,106,431...108,179,345
Ensembl chr12:108,106,431...108,179,314 		JBrowse link
G Setd5 SET domain containing 5 increases expression ISO Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 6:113,077,262...113,153,432
Ensembl chr 6:113,077,365...113,153,435 		JBrowse link
G Setd6 SET domain containing 6 increases expression ISO Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr 8:95,715,634...95,721,507
Ensembl chr 8:95,715,881...95,719,010 		JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 increases expression ISO Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 3:51,515,318...51,560,823
Ensembl chr 3:51,515,319...51,560,879 		JBrowse link
G Setdb1 SET domain, bifurcated 1 increases expression ISO Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 3:95,323,525...95,357,202
Ensembl chr 3:95,323,525...95,357,202 		JBrowse link
G Setdb2 SET domain, bifurcated 2 increases expression ISO Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr14:59,402,009...59,440,880
Ensembl chr14:59,402,009...59,440,884 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]		 CTD PMID:26712469 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr 7:28,766,752...28,788,665
Ensembl chr 7:28,766,735...28,788,661 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression		 ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein		 CTD PMID:26712469 PMID:27311644 NCBI chr 7:140,863,663...140,882,309
Ensembl chr 7:140,863,666...140,882,309 		JBrowse link
G Sis sucrase isomaltase (alpha-glucosidase) decreases expression
multiple interactions		 ISO Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]		 CTD PMID:20229011 NCBI chr 3:72,888,557...72,967,863
Ensembl chr 3:72,888,557...72,967,863 		JBrowse link
G Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 decreases expression ISO Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr 7:12,988,346...12,998,192
Ensembl chr 7:12,988,346...12,998,192 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr11:69,942,286...69,948,216
Ensembl chr11:69,942,539...69,948,188 		JBrowse link
G Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr13:73,679,745...73,700,780
Ensembl chr13:73,679,745...73,704,865 		JBrowse link
G Smyd3 SET and MYND domain containing 3 affects expression ISO Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:178,951,960...179,518,053
Ensembl chr 1:178,951,960...179,518,041 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA] CTD PMID:21095217 PMID:22775417 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP
ISO		 Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]		 CTD PMID:22775417 PMID:24751971 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760 		JBrowse link
G Sp7 Sp7 transcription factor 7 increases expression ISO Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr15:102,356,603...102,367,035
Ensembl chr15:102,356,606...102,367,182 		JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein increases expression ISO Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr11:55,394,159...55,420,080
Ensembl chr11:55,394,500...55,423,183 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]		 CTD PMID:26478571 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA		 CTD PMID:20564506 PMID:26478571 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr13:73,626,911...73,649,843
Ensembl chr13:73,626,911...73,649,843 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]		 CTD PMID:17973934 PMID:23523906 PMID:30138605 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:21963898 PMID:30240693 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO
EXP		 Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]		 CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 PMID:25600690 PMID:28533128 PMID:29170048 PMID:30240693 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Top1 topoisomerase (DNA) I decreases activity ISO Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 2:160,645,897...160,722,764
Ensembl chr 2:160,645,888...160,722,764 		JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions
affects response to substance		 ISO TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine		 CTD PMID:23747414 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 2:34,941,750...34,961,812
Ensembl chr 2:34,941,750...34,961,772 		JBrowse link
G Traf2 TNF receptor-associated factor 2 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 2:25,517,982...25,546,940
Ensembl chr 2:25,517,982...25,546,940 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein		 CTD PMID:20656010 PMID:26712469 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 increases expression ISO Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:171,419,033...171,420,352
Ensembl chr 1:171,418,872...171,420,352 		JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:36,874,295...36,884,222
Ensembl chr  X:36,873,900...36,884,222 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr11:51,985,138...52,004,145
Ensembl chr11:51,985,497...52,000,762 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions EXP Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA] CTD PMID:28533128 NCBI chr 7:100,493,337...100,499,629
Ensembl chr 7:100,493,337...100,502,020 		JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 8:54,077,532...54,186,454
Ensembl chr 8:54,077,606...54,187,096 		JBrowse link
dofetilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1b FK506 binding protein 1b multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein] CTD PMID:20723002 NCBI chr12:4,833,176...4,841,573
Ensembl chr12:4,833,174...4,841,591 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions
decreases activity
affects binding		 ISO [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 protein; Acids inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]; dofetilide binds to and results in decreased activity of KCNH2 protein; dofetilide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium affects the reaction [dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]]; Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium promotes the reaction [dofetilide binds to KCNH2 protein] CTD PMID:9395068 PMID:10828461 PMID:15272206 PMID:15821840 PMID:15961988 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18701618 PMID:20071423 PMID:21158687 PMID:24052561 PMID:24200993 PMID:24830940 PMID:30561737 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein] CTD PMID:20723002 NCBI chr 1:152,800,153...152,836,990
Ensembl chr 1:152,800,194...152,836,991 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein] CTD PMID:20723002 NCBI chr17:86,167,785...86,657,919
Ensembl chr17:86,167,785...86,657,919 		JBrowse link
ezogabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit affects activity ISO ezogabine affects the activity of CACNA1C protein CTD PMID:28641963 NCBI chr 6:118,587,240...119,197,384
Ensembl chr 6:118,587,240...119,196,890
Ensembl chr 6:118,587,240...119,196,890 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 affects activity ISO ezogabine affects the activity of KCNH2 protein CTD PMID:28641963 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 multiple interactions
affects activity		 EXP
ISO		 ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]
ezogabine affects the activity of KCNQ2 protein		 CTD PMID:15634793 PMID:26627826 NCBI chr 2:181,075,579...181,135,580
Ensembl chr 2:181,075,579...181,135,300 		JBrowse link
G Kcnq3 potassium voltage-gated channel, subfamily Q, member 3 affects activity
decreases response to substance		 ISO ezogabine affects the activity of KCNQ3 protein
KCNQ3 protein mutant form results in decreased susceptibility to ezogabine		 CTD PMID:26627826 NCBI chr15:65,986,374...66,286,636
Ensembl chr15:65,986,387...66,286,642 		JBrowse link
G Kcnq4 potassium voltage-gated channel, subfamily Q, member 4 multiple interactions
increases activity		 ISO [ezogabine results in increased activity of KCNQ4 protein] which results in increased export of Rubidium; [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of Thallium CTD PMID:16904708 PMID:21782781 NCBI chr 4:120,696,134...120,747,491
Ensembl chr 4:120,696,138...120,748,612 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha affects activity ISO ezogabine affects the activity of SCN5A protein CTD PMID:28641963 NCBI chr 9:119,483,404...119,579,030
Ensembl chr 9:119,483,408...119,579,016 		JBrowse link
nicorandil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 increases activity EXP Nicorandil results in increased activity of ABCC9 protein CTD PMID:22622455 NCBI chr 6:142,587,862...142,702,766
Ensembl chr 6:142,587,862...142,702,315 		JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions EXP Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein] CTD PMID:22622455 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706 		JBrowse link
G Bax BCL2-associated X protein multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:31376360 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:31376360 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Cat catalase multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:31376360 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Ctsd cathepsin D multiple interactions ISO [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr 7:142,375,910...142,387,827
Ensembl chr 7:142,375,911...142,388,038 		JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions ISO [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr19:3,409,915...3,414,544
Ensembl chr19:3,409,915...3,414,544 		JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr 5:129,989,011...130,003,049
Ensembl chr 5:129,989,011...130,003,049 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:31376360 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO Nicorandil results in decreased expression of HMOX1 protein CTD PMID:22622455 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:31376360 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of MPO protein] CTD PMID:31376360 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] CTD PMID:31376360 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein] CTD PMID:31376360 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression ISO Nicorandil results in increased expression of SOD2 protein CTD PMID:22622455 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein] CTD PMID:31376360 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:31376360 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
decreases expression		 EXP
ISO		 Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein]
Nicorandil results in decreased expression of XDH protein		 CTD PMID:22622455 NCBI chr17:73,883,895...73,950,397
Ensembl chr17:73,883,895...73,950,196 		JBrowse link
NS 1619 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]] CTD PMID:21413024 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions ISO NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011 		JBrowse link
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 multiple interactions ISO NS 1619 binds to and results in increased activity of KCNMA1 protein; NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr14:23,292,288...24,005,110
Ensembl chr14:23,289,431...24,014,491 		JBrowse link
G Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 multiple interactions ISO NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr11:33,962,955...33,973,641
Ensembl chr11:33,963,013...33,973,641 		JBrowse link
quinidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects transport
increases transport
affects binding
affects response to substance
decreases expression
multiple interactions		 ISO
EXP		 ABCB1 protein affects the transport of Quinidine
ABCB1 protein results in increased transport of Quinidine
Quinidine binds to ABCB1 protein
ABCB1A protein affects the susceptibility to Quinidine
Quinidine results in decreased expression of ABCB1 protein
methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]		 CTD PMID:15502009 PMID:15616150 PMID:20196146 PMID:23976943 PMID:26995013 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B affects response to substance
affects activity		 EXP
ISO		 ABCB1B protein affects the susceptibility to Quinidine
Quinidine affects the activity of ABCB1B protein		 CTD PMID:12626638 PMID:15502009 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain decreases expression ISO Quinidine results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a affects binding
multiple interactions		 ISO Quinidine binds to ADRA1A protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr14:66,635,251...66,771,240
Ensembl chr14:66,635,251...66,771,168 		JBrowse link
G Adra1b adrenergic receptor, alpha 1b affects binding
multiple interactions		 ISO Quinidine binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr11:43,774,605...43,901,250
Ensembl chr11:43,774,606...43,901,210 		JBrowse link
G Adra1d adrenergic receptor, alpha 1d affects binding
multiple interactions		 ISO Quinidine binds to ADRA1D protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]		 CTD PMID:9570190 NCBI chr 2:131,545,357...131,562,497
Ensembl chr 2:131,545,850...131,562,283 		JBrowse link
G Aldoa aldolase A, fructose-bisphosphate increases expression ISO Quinidine results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr 7:126,795,234...126,800,994
Ensembl chr 7:126,795,234...126,800,751
Ensembl chr 7:126,795,234...126,800,751 		JBrowse link
G Asns asparagine synthetase increases expression ISO Quinidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254 		JBrowse link
G Cat catalase increases expression EXP Quinidine results in increased expression of CAT protein CTD PMID:12708743 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) increases expression ISO Quinidine results in increased expression of CDKN1A protein CTD PMID:12243503 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 increases expression ISO Quinidine results in increased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr 7:25,461,702...25,477,647
Ensembl chr 7:25,461,707...25,477,603 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 decreases expression ISO Quinidine results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr15:83,153,495...83,176,440
Ensembl chr15:83,153,494...83,172,592 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO
EXP		 Quinidine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Quinidine results in decreased activity of CYP1A1 protein		 CTD PMID:18420780 PMID:18493746 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Quinidine affects the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP1A2 protein		 CTD PMID:15916432 PMID:19053182 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity EXP Quinidine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061 		JBrowse link
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 decreases activity EXP Quinidine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr 7:26,307,192...26,315,088
Ensembl chr 7:26,307,169...26,315,088 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 decreases activity EXP Quinidine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity EXP Quinidine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 multiple interactions
decreases activity		 ISO Quinidine affects the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP2C6V1 protein		 CTD PMID:12814958 PMID:19053182 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases activity EXP Quinidine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 multiple interactions
decreases activity
increases metabolic processing		 ISO
EXP		 [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride
Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]
CYP2D6 protein results in increased metabolism of Quinidine		 CTD PMID:8819299 PMID:11377097 PMID:11560869 PMID:11673748 PMID:12464242 PMID:12467917 PMID:12569440 PMID:12814958 PMID:14652237 PMID:15155557 PMID:15306208 PMID:15860655 PMID:16035375 PMID:16595712 PMID:17702393 PMID:18238857 PMID:18420780 PMID:19230594 PMID:19328226 PMID:20345925 PMID:20590588 PMID:20669986 PMID:21277363 PMID:21336516 PMID:21915887 PMID:23850985 PMID:24167220 PMID:26599973 PMID:28119166 PMID:28887089 PMID:31515991 PMID:32198085 NCBI chr15:82,370,527...82,380,260
Ensembl chr15:82,370,527...82,380,260 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP Quinidine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 decreases activity EXP Quinidine results in decreased activity of CYP3A11 protein CTD PMID:18420780 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964 		JBrowse link
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 decreases activity EXP Quinidine results in decreased activity of CYP3A4 protein CTD PMID:18420780 NCBI chr 5:145,773,983...145,805,891
Ensembl chr 5:145,773,983...145,805,874 		JBrowse link
G Depp1 DEPP1 autophagy regulator increases expression ISO Quinidine results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr 6:116,650,684...116,652,847
Ensembl chr 6:116,650,609...116,652,794 		JBrowse link
G Fabp1 fatty acid binding protein 1, liver increases expression ISO Quinidine results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 6:71,199,879...71,205,034
Ensembl chr 6:71,199,827...71,205,023 		JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Quinidine results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 3:83,026,153...83,033,627
Ensembl chr 3:83,026,076...83,033,627 		JBrowse link
G Fgb fibrinogen beta chain increases expression ISO Quinidine results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 3:83,042,246...83,049,863
Ensembl chr 3:83,040,141...83,049,863 		JBrowse link
G Gstm1 glutathione S-transferase, mu 1 decreases activity ISO Quinidine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression ISO Quinidine results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 3:107,895,854...107,898,685
Ensembl chr 3:107,895,821...107,898,686 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
decreases activity		 ISO Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinidine results in decreased activity of GSTP1 protein		 CTD PMID:11807801 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase increases expression ISO Quinidine results in increased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 6:52,546,230...52,640,300
Ensembl chr 6:52,546,228...52,640,389 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042 		JBrowse link
G Inhbe inhibin beta-E increases expression ISO Quinidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr10:127,349,402...127,351,848
Ensembl chr10:127,348,857...127,354,411 		JBrowse link
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 multiple interactions ISO Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 1:192,189,144...192,510,159
Ensembl chr 1:192,190,774...192,510,159 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 multiple interactions
decreases activity
affects activity
affects binding
affects localization
affects response to substance
decreases response to substance		 ISO [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]
Quinidine affects the activity of KCNH2 protein
Quinidine binds to KCNH2 protein
Quinidine affects the localization of KCNH2 protein mutant form
KCNH2 gene SNP affects the susceptibility to Quinidine
KCNH2 gene mutant form results in decreased susceptibility to Quinidine		 CTD PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18701618 PMID:18724381 PMID:19583963 PMID:21158687 PMID:21362439 PMID:22020101 PMID:24052561 PMID:28551711 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604 		JBrowse link
G Kcnk1 potassium channel, subfamily K, member 1 multiple interactions EXP Quinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]; Quinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium] CTD PMID:16847696 NCBI chr 8:125,993,655...126,030,685
Ensembl chr 8:125,995,170...126,030,685 		JBrowse link
G Kcnk18 potassium channel, subfamily K, member 18 multiple interactions ISO Quinidine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr19:59,219,648...59,237,370
Ensembl chr19:59,219,214...59,237,374 		JBrowse link
G Kcnk9 potassium channel, subfamily K, member 9 multiple interactions ISO Quinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr15:72,501,873...72,548,614
Ensembl chr15:72,501,089...72,546,340 		JBrowse link
G Lbp lipopolysaccharide binding protein increases expression ISO Quinidine results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 2:158,306,493...158,332,852
Ensembl chr 2:158,306,493...158,332,852 		JBrowse link
G Lipc lipase, hepatic decreases expression ISO Quinidine results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 9:70,798,128...70,952,221
Ensembl chr 9:70,798,128...70,952,226 		JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO Quinidine results in decreased expression of MYC mRNA CTD PMID:17522070 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374 		JBrowse link
G Nupr1 nuclear protein transcription regulator 1 increases expression ISO Quinidine results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861 		JBrowse link
G Otc ornithine transcarbamylase decreases expression ISO Quinidine results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:10,252,230...10,321,024
Ensembl chr  X:10,252,305...10,321,024 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell decreases expression ISO Quinidine results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 3:89,136,122...89,146,815
Ensembl chr 3:89,136,142...89,146,784 		JBrowse link
G Ptma prothymosin alpha decreases expression ISO Quinidine results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 1:86,526,557...86,530,712
Ensembl chr 1:86,526,726...86,530,712 		JBrowse link
G S100a9 S100 calcium binding protein A9 (calgranulin B) increases expression ISO Quinidine results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 3:90,692,630...90,695,721
Ensembl chr 3:90,692,632...90,695,721 		JBrowse link
G Scn5a sodium channel, voltage-gated, type V, alpha affects response to substance EXP SCN5A gene mutant form affects the susceptibility to Quinidine CTD PMID:17805561 NCBI chr 9:119,483,404...119,579,030
Ensembl chr 9:119,483,408...119,579,016 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions ISO [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]		 CTD PMID:16141367 PMID:21140131 PMID:23831208 PMID:24799337 PMID:24947867 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829 		JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16141367 PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488 		JBrowse link
G Slc22a3 solute carrier family 22 (organic cation transporter), member 3 multiple interactions ISO Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 NCBI chr17:12,419,972...12,507,704
Ensembl chr17:12,418,960...12,507,704 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 decreases expression ISO Quinidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:122,727,809...122,802,363
Ensembl chr 6:122,727,809...122,801,640 		JBrowse link
G Slc47a1 solute carrier family 47, member 1 decreases activity
multiple interactions		 ISO Quinidine results in decreased activity of SLC47A1 protein
Quinidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]		 CTD PMID:16928787 PMID:22419765 NCBI chr11:61,343,400...61,378,842
Ensembl chr11:61,343,401...61,378,345 		JBrowse link
G Slc47a2 solute carrier family 47, member 2 multiple interactions ISO Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr11:61,301,627...61,342,860
Ensembl chr11:61,301,631...61,342,860 		JBrowse link
G Tagln transgelin decreases expression ISO Quinidine results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr 9:45,929,628...45,936,058
Ensembl chr 9:45,929,619...45,936,058 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 increases expression ISO Quinidine results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a decreases expression ISO Quinidine results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 6:125,349,723...125,362,483
Ensembl chr 6:125,349,362...125,362,484 		JBrowse link
G Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 decreases expression ISO Quinidine results in decreased expression of TNFRSF8 protein CTD PMID:12441127 NCBI chr 4:145,267,132...145,315,164
Ensembl chr 4:145,267,137...145,315,164 		JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO Quinidine results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
tolbutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A decreases activity
multiple interactions		 ISO Tolbutamide results in decreased activity of ABCB1 protein
Tolbutamide inhibits the reaction [ABCB1 protein results in increased uptake of quinidinium]		 CTD PMID:32305507 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575 		JBrowse link
G Abcc8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 multiple interactions ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] CTD PMID:9568693 PMID:18025464 PMID:22209866 NCBI chr 7:46,104,523...46,180,039
Ensembl chr 7:46,104,523...46,180,033 		JBrowse link
G Alb albumin affects binding ISO Tolbutamide binds to ALB protein CTD PMID:19596536 PMID:20435530 PMID:20956006 PMID:20974553 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Tolbutamide results in increased expression of CCND1 protein CTD PMID:16718685 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Ccnd3 cyclin D3 increases expression ISO Tolbutamide results in increased expression of CCND3 protein CTD PMID:16718685 NCBI chr17:47,505,051...47,599,689
Ensembl chr17:47,505,051...47,599,691 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression		 ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein] CTD PMID:16718685 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Tolbutamide results in increased expression of CDKN1B protein CTD PMID:16718685 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513 		JBrowse link
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 increases metabolic processing
multiple interactions		 EXP CYP2C23 protein results in increased metabolism of Tolbutamide
[CYP2C23 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:44,005,022...44,029,256
Ensembl chr19:44,005,022...44,029,208 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Tolbutamide CTD PMID:15843491 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases metabolic processing
multiple interactions
increases hydroxylation		 ISO CYP2C19 protein results in increased metabolism of Tolbutamide
[CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:18511451 PMID:30500380 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075 		JBrowse link
G Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 multiple interactions
increases metabolic processing		 EXP [CYP2C39 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,347,346...39,569,568
Ensembl chr19:39,510,862...39,568,529 		JBrowse link
G Cyp2c40 cytochrome P450, family 2, subfamily c, polypeptide 40 increases metabolic processing
multiple interactions		 EXP CYP2C40 protein results in increased metabolism of Tolbutamide
[CYP2C40 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:39,767,073...39,812,814
Ensembl chr19:39,767,071...39,812,814 		JBrowse link
G Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 increases metabolic processing
multiple interactions		 EXP CYP2C50 protein results in increased metabolism of Tolbutamide
[CYP2C50 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:40,089,679...40,113,955
Ensembl chr19:40,089,688...40,113,950 		JBrowse link
G Cyp2c54 cytochrome P450, family 2, subfamily c, polypeptide 54 increases metabolic processing
multiple interactions		 EXP CYP2C54 protein results in increased metabolism of Tolbutamide
[CYP2C54 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:40,037,939...40,073,845
Ensembl chr19:40,037,940...40,073,827 		JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 increases metabolic processing
multiple interactions		 ISO
EXP		 CYP2C18 results in increased metabolism of Tolbutamide
CYP2C55 protein results in increased metabolism of Tolbutamide
[CYP2C55 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:15301741 PMID:30503582 NCBI chr19:39,006,940...39,042,690
Ensembl chr19:39,007,019...39,042,693 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 decreases hydroxylation
increases metabolic processing
multiple interactions
increases hydroxylation
increases hydrolysis
affects hydroxylation
affects metabolic processing
decreases metabolic processing
increases chemical synthesis		 ISO
EXP		 CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C65 protein results in increased metabolism of Tolbutamide
[CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased hydroxylation of Tolbutamide
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite		 CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 PMID:10611138 PMID:11377097 PMID:11875364 PMID:12426520 PMID:12433797 PMID:12464242 PMID:12467917 PMID:15045499 PMID:15155557 PMID:15327588 PMID:15370959 PMID:15626586 PMID:15843491 PMID:15856409 PMID:16081671 PMID:16124035 PMID:17267297 PMID:17565714 PMID:17702393 PMID:19082874 PMID:19715737 PMID:21915887 PMID:22634058 PMID:23850985 PMID:25994031 PMID:26255664 PMID:26763401 PMID:30503582 PMID:32198085 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 decreases hydroxylation
increases metabolic processing
multiple interactions
increases hydroxylation
increases hydrolysis
affects hydroxylation
affects metabolic processing
decreases metabolic processing
increases chemical synthesis		 ISO
EXP		 CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C66 protein results in increased metabolism of Tolbutamide
[CYP2C66 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased hydroxylation of Tolbutamide
CYP2C9 protein results in increased metabolism of Tolbutamide
CYP2C9 protein results in increased hydrolysis of Tolbutamide
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite		 CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 PMID:10611138 PMID:11377097 PMID:11875364 PMID:12426520 PMID:12433797 PMID:12464242 PMID:12467917 PMID:15045499 PMID:15155557 PMID:15327588 PMID:15370959 PMID:15626586 PMID:15843491 PMID:15856409 PMID:16081671 PMID:16124035 PMID:17267297 PMID:17565714 PMID:17702393 PMID:19082874 PMID:19715737 PMID:21915887 PMID:22634058 PMID:23850985 PMID:25994031 PMID:26255664 PMID:26763401 PMID:30503582 PMID:32198085 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072 		JBrowse link
G Cyp2c67 cytochrome P450, family 2, subfamily c, polypeptide 67 increases metabolic processing
multiple interactions		 EXP CYP2C67 protein results in increased metabolism of Tolbutamide
[CYP2C67 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:39,608,844...39,649,079
Ensembl chr19:39,608,842...39,649,051 		JBrowse link
G Cyp2c68 cytochrome P450, family 2, subfamily c, polypeptide 68 multiple interactions
increases metabolic processing		 EXP [CYP2C68 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,688,836...39,741,101
Ensembl chr19:39,688,834...39,741,054 		JBrowse link
G Cyp2c69 cytochrome P450, family 2, subfamily c, polypeptide 69 multiple interactions
increases metabolic processing		 EXP [CYP2C69 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr19:39,842,660...39,886,769
Ensembl chr19:39,842,814...39,886,799 		JBrowse link
G Cyp2c70 cytochrome P450, family 2, subfamily c, polypeptide 70 increases metabolic processing
multiple interactions		 EXP CYP2C70 protein results in increased metabolism of Tolbutamide
[CYP2C70 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide		 CTD PMID:30503582 NCBI chr19:40,153,361...40,187,286
Ensembl chr19:40,153,353...40,187,333 		JBrowse link
G Gcg glucagon increases secretion ISO Tolbutamide results in increased secretion of GCG protein CTD PMID:15919803 NCBI chr 2:62,474,530...62,483,653
Ensembl chr 2:62,474,530...62,483,650 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases expression		 ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein]; Tolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]
Tolbutamide results in increased expression of GJA1 protein		 CTD PMID:11741589 PMID:16718685 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513 		JBrowse link
G Hk1 hexokinase 1 increases expression EXP Tolbutamide results in increased expression of HK1 protein CTD PMID:11835228 NCBI chr10:62,268,855...62,379,920
Ensembl chr10:62,268,855...62,379,908 		JBrowse link
G Ins1 insulin I affects secretion EXP Tolbutamide affects the secretion of INS1 protein CTD PMID:9366569 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476 		JBrowse link
G Ins2 insulin II multiple interactions
increases secretion		 ISO ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9032110 PMID:9568693 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381 		JBrowse link
G Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 multiple interactions
decreases activity		 ISO [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]
Tolbutamide results in decreased activity of KCNJ11 protein		 CTD PMID:18025464 PMID:22209866 NCBI chr 7:46,097,123...46,100,952
Ensembl chr 7:46,093,953...46,100,764 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 decreases expression ISO Tolbutamide results in decreased expression of MKI67 protein CTD PMID:16718685 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361 		JBrowse link
G Pdcd4 programmed cell death 4 decreases expression
increases expression		 ISO Tolbutamide results in decreased expression of PDCD4 mRNA
Tolbutamide results in increased expression of PDCD4 mRNA		 CTD PMID:21873647 NCBI chr19:53,892,231...53,937,592
Ensembl chr19:53,892,231...53,929,860 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tolbutamide results in decreased phosphorylation of RB1 protein CTD PMID:16718685 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression EXP Tolbutamide results in increased expression of SLC2A1 mRNA; Tolbutamide results in increased expression of SLC2A1 protein CTD PMID:2682625 PMID:11835228 NCBI chr 4:119,108,745...119,137,330
Ensembl chr 4:119,108,711...119,137,983 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 decreases expression ISO Tolbutamide results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr10:19,000,910...19,015,410
Ensembl chr10:19,000,910...19,015,657 		JBrowse link
G Tpd52 tumor protein D52 decreases expression
increases expression		 ISO Tolbutamide results in decreased expression of TPD52 mRNA
Tolbutamide results in increased expression of TPD52 mRNA		 CTD PMID:21873647 NCBI chr 3:8,926,530...9,005,393
Ensembl chr 3:8,925,593...9,004,723 		JBrowse link
G Trp53 transformation related protein 53 increases expression ISO Tolbutamide results in increased expression of TP53 mRNA CTD PMID:16426753 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Ugdh UDP-glucose dehydrogenase decreases expression ISO Tolbutamide results in decreased expression of UGDH protein CTD PMID:4270849 NCBI chr 5:65,413,207...65,435,842
Ensembl chr 5:65,413,221...65,435,949 		JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) increases expression ISO Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 affects expression ISO Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr15:74,834,892...74,841,643
Ensembl chr15:74,834,125...74,841,643 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713 		JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene affects metabolic processing ISO CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases hydroxylation
increases metabolic processing		 ISO CYP2C9 protein results in increased hydroxylation of Torsemide
CYP2C9 protein results in increased metabolism of Torsemide		 CTD PMID:9110362 PMID:19082874 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing
increases hydroxylation		 ISO CYP2C9 protein results in increased metabolism of Torsemide
CYP2C9 protein results in increased hydroxylation of Torsemide		 CTD PMID:9110362 PMID:19082874 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072 		JBrowse link
G Nppa natriuretic peptide type A decreases expression ISO Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr 8:76,898,083...77,245,012
Ensembl chr 8:76,899,442...77,245,012 		JBrowse link
G Ren1 renin 1 structural increases expression ISO Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 decreases activity
multiple interactions		 ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:29959396 NCBI chr18:57,878,512...57,946,821
Ensembl chr18:57,878,678...57,946,821 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
decreases expression		 ISO Torsemide affects the expression of TGFB1 protein
Torsemide results in decreased expression of TGFB1 protein		 CTD PMID:18001696 PMID:18154949 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
trans-piceid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects export ISO ABCC2 protein affects the export of polydatin CTD PMID:15686436 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676 		JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of MYH7 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein] CTD PMID:25488910 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706 		JBrowse link
G Ahr aryl-hydrocarbon receptor decreases localization
multiple interactions		 ISO polydatin results in decreased localization of AHR protein
polydatin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]		 CTD PMID:21756928 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator increases localization ISO polydatin results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 3:95,434,367...95,497,240
Ensembl chr 3:95,434,388...95,497,240 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP
ISO		 cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]
polydatin inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]		 CTD PMID:27481074 PMID:28980048 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 cyclopamine inhibits the reaction [polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]
polydatin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]		 CTD PMID:27481074 PMID:29130132 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions
decreases secretion
decreases expression		 ISO polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; polydatin inhibits the reaction [PD168393 results in increased expression of CCL2 mRNA]
polydatin results in decreased secretion of CCL2 protein
polydatin results in decreased expression of CCL2 mRNA		 CTD PMID:21756928 PMID:21967610 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA] CTD PMID:27481074 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925 		JBrowse link
G Ccnd2 cyclin D2 multiple interactions EXP cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA] CTD PMID:27481074 NCBI chr 6:127,125,162...127,152,188
Ensembl chr 6:127,125,162...127,152,193 		JBrowse link
G Cxcl10 chemokine (C-X-C motif) ligand 10 multiple interactions
decreases secretion
decreases expression		 ISO [polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin inhibits the reaction [PD168393 results in increased expression of CXCL10 mRNA]
polydatin results in decreased secretion of CXCL10 protein
polydatin results in decreased expression of CXCL10 mRNA		 CTD PMID:21756928 PMID:21967610 NCBI chr 5:92,346,638...92,348,889
Ensembl chr 5:92,346,638...92,348,889 		JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 multiple interactions
decreases expression
increases secretion		 ISO [polydatin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
polydatin results in decreased expression of CXCL8 mRNA
polydatin results in increased secretion of CXCL8 protein		 CTD PMID:21756928 PMID:21967610 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein] CTD PMID:25488910 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO polydatin results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO polydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions EXP ESR2 gene mutant form inhibits the reaction [polydatin results in increased expression of SOD2 protein] CTD PMID:24361291 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked decreases activity ISO polydatin results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194 		JBrowse link
G Gli1 GLI-Kruppel family member GLI1 multiple interactions EXP cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein] CTD PMID:27481074 NCBI chr10:127,329,882...127,341,579
Ensembl chr10:127,329,882...127,341,974 		JBrowse link
G Hlcs holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) decreases activity ISO polydatin results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr16:94,129,306...94,315,239
Ensembl chr16:94,128,882...94,313,571 		JBrowse link
G Ifng interferon gamma multiple interactions ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA] CTD PMID:29130132 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO polydatin inhibits the reaction [OVAL protein results in increased secretion of IL4 protein] CTD PMID:23840142 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
polydatin results in decreased expression of IL6 mRNA		 CTD PMID:21756928 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions ISO
EXP		 polydatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]
polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein]		 CTD PMID:31705858 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361 		JBrowse link
G Lct lactase increases hydrolysis ISO LCT protein results in increased hydrolysis of polydatin analog CTD PMID:17009167 NCBI chr 1:128,284,756...128,328,318
Ensembl chr 1:128,284,756...128,328,318 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [polydatin results in increased phosphorylation of MAPK1 protein]
polydatin results in decreased phosphorylation of MAPK1 protein		 CTD PMID:21756928 PMID:28980048 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation		 ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [polydatin results in increased phosphorylation of MAPK3 protein]
polydatin results in decreased phosphorylation of MAPK3 protein		 CTD PMID:21756928 PMID:28980048 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions
increases phosphorylation		 ISO XMD 8-92 inhibits the reaction [polydatin results in increased phosphorylation of MAPK7 protein] CTD PMID:28980048 NCBI chr11:61,488,812...61,494,267
Ensembl chr11:61,488,812...61,494,406 		JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of MYH7 mRNA] CTD PMID:25488910 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO
EXP		 [polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein; NFE2L2 protein affects the reaction [[polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]
polydatin inhibits the reaction [TSHR protein results in decreased expression of NFE2L2 protein]		 CTD PMID:31705858 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 protein] CTD PMID:25488910 NCBI chr 7:87,244,430...87,398,710
Ensembl chr 7:87,246,096...87,398,710 		JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:25449040 PMID:25488910 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO
EXP		 NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]; polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
polydatin inhibits the reaction [TSHR protein results in decreased expression of NQO1 protein]		 CTD PMID:31705858 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 affects response to substance EXP ORAI1 protein affects the susceptibility to polydatin CTD PMID:22959927 NCBI chr 5:123,015,074...123,030,452
Ensembl chr 5:123,015,074...123,030,456 		JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific decreases activity ISO polydatin results in decreased activity of PDE5A protein CTD PMID:15769121 NCBI chr 3:122,729,158...122,859,374
Ensembl chr 3:122,728,947...122,859,374 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions ISO polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:25449040 NCBI chr10:108,162,092...108,279,985
Ensembl chr10:108,162,193...108,284,475 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP polydatin results in decreased activity of PTGS1 protein CTD PMID:11962253 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity		 ISO
EXP		 [polydatin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA
polydatin results in decreased activity of PTGS2 protein		 CTD PMID:11962253 PMID:21756928 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA mRNA]		 CTD PMID:21756928 PMID:29130132 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein] CTD PMID:25449040 NCBI chr 9:108,306,160...108,337,943
Ensembl chr 9:108,306,129...108,337,934 		JBrowse link
G Shh sonic hedgehog multiple interactions EXP polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein] CTD PMID:27481074 NCBI chr 5:28,456,840...28,467,101
Ensembl chr 5:28,456,815...28,467,256 		JBrowse link
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 NCBI chr17:12,648,874...12,675,838
Ensembl chr17:12,648,869...12,675,829 		JBrowse link
G Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 NCBI chr19:6,535,854...6,543,070
Ensembl chr19:6,535,845...6,543,032 		JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:22865646 NCBI chr11:53,983,115...54,030,040
Ensembl chr11:53,983,123...54,028,090 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein] CTD PMID:22865646 NCBI chr11:53,864,542...53,891,796
Ensembl chr11:53,864,542...53,891,660 		JBrowse link
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein] CTD PMID:22865646 NCBI chr19:8,617,996...8,628,299
Ensembl chr19:8,618,039...8,628,299 		JBrowse link
G Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein] CTD PMID:22865646 NCBI chr 5:38,349,272...38,503,147
Ensembl chr 5:38,349,273...38,503,143 		JBrowse link
G Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 affects uptake ISO SLC5A1 protein affects the uptake of polydatin CTD PMID:15686436 NCBI chr 5:33,104,219...33,162,699
Ensembl chr 5:33,104,219...33,162,870 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
increases expression		 ISO
EXP		 polydatin results in increased expression of and results in increased activity of SOD2 protein
polydatin results in increased expression of SOD2 protein
ESR2 gene mutant form inhibits the reaction [polydatin results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [polydatin results in increased expression of SOD2 protein]		 CTD PMID:24361291 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO [polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA; [polydatin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; polydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928 PMID:21967610 NCBI chr 6:86,195,038...86,275,744
Ensembl chr 6:86,195,223...86,275,719 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein] CTD PMID:25488910 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]
polydatin results in decreased expression of TNF mRNA		 CTD PMID:21756928 PMID:29130132 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions ISO polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA] CTD PMID:29130132 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873 		JBrowse link
G Tshr thyroid stimulating hormone receptor multiple interactions EXP polydatin inhibits the reaction [TSHR protein results in decreased expression of NFE2L2 protein]; polydatin inhibits the reaction [TSHR protein results in decreased expression of NQO1 protein]; polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein] CTD PMID:31705858 NCBI chr12:91,400,993...91,540,509
Ensembl chr12:91,384,563...91,549,808 		JBrowse link
G Tug1 taurine upregulated gene 1 decreases expression ISO polydatin results in decreased expression of TUG1 mRNA CTD PMID:30974157 NCBI chr11:3,639,785...3,648,814
Ensembl chr11:3,639,785...3,649,673 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases hydrolysis ISO UGT1A1 protein results in increased hydrolysis of polydatin metabolite CTD PMID:17009167 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997 		JBrowse link
G Umod uromodulin multiple interactions EXP polydatin inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein] CTD PMID:22865646 NCBI chr 7:119,462,708...119,479,262
Ensembl chr 7:119,462,711...119,479,282 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    role 21539
      biological role 21537
        biophysical role 12820
          membrane transport modulator 12588
            potassium channel modulator 381
              ezogabine 6
              potassium channel blocker + 332
              potassium channel opener + 25
              trans-piceid 57
paths to the root