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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:potassium channel modulator
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Accession:CHEBI:50510 term browser browse the term


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2-aminoethoxydiphenylborane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased expression of BAX protein] CTD PMID:29883672 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in decreased expression of BCL2 protein] CTD PMID:29883672 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP12 caspase 12 (gene/pseudogene) multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased cleavage of CASP12 protein] CTD PMID:29883672 NCBI chr11:104,885,718...104,898,460
Ensembl chr11:104,885,718...104,898,670
JBrowse link
G CASP3 caspase 3 multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [cadmium acetate results in increased cleavage of CASP3 protein] CTD PMID:29883672 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CD28 CD28 molecule multiple interactions EXP 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Calcium]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Nitric Oxide]; 2-aminoethoxydiphenylborane inhibits the reaction [CD28 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:14607919 NCBI chr 2:203,706,509...203,739,756
Ensembl chr 2:203,706,475...203,738,912
JBrowse link
G GRM1 glutamate metabotropic receptor 1 multiple interactions ISO 2-aminoethoxydiphenylborane inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM1 protein] CTD PMID:14622174 NCBI chr 6:146,027,634...146,437,601
Ensembl chr 6:146,027,646...146,437,601
JBrowse link
4-aminopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1B adrenoceptor alpha 1B multiple interactions ISO 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] CTD PMID:18480251 NCBI chr 5:159,916,482...159,989,205
Ensembl chr 5:159,865,080...159,973,012
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO 4-Aminopyridine results in increased expression of BAX mRNA CTD PMID:24378259 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 decreases expression ISO 4-Aminopyridine results in decreased expression of BIRC2 mRNA CTD PMID:24378259 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 decreases expression ISO 4-Aminopyridine results in decreased expression of BIRC3 mRNA CTD PMID:24378259 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BMF Bcl2 modifying factor increases expression ISO 4-Aminopyridine results in increased expression of BMF mRNA CTD PMID:24378259 NCBI chr15:40,087,890...40,108,879
Ensembl chr15:40,087,890...40,108,892
JBrowse link
G C1orf159 chromosome 1 open reading frame 159 increases expression ISO 4-Aminopyridine results in increased expression of C1ORF159 mRNA CTD PMID:24378259 NCBI chr 1:1,081,823...1,116,089
Ensembl chr 1:1,081,818...1,116,361
JBrowse link
G CASP3 caspase 3 increases activity ISO 4-Aminopyridine results in increased activity of CASP3 protein CTD PMID:24378259 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases activity ISO 4-Aminopyridine results in increased activity of CASP7 protein CTD PMID:24378259 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP9 caspase 9 increases activity ISO 4-Aminopyridine results in increased activity of CASP9 protein CTD PMID:24378259 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CD40 CD40 molecule increases expression ISO 4-Aminopyridine results in increased expression of CD40 mRNA CTD PMID:24378259 NCBI chr20:46,118,242...46,129,858
Ensembl chr20:46,118,278...46,129,863
JBrowse link
G CD40LG CD40 ligand increases expression ISO 4-Aminopyridine results in increased expression of CD40LG mRNA CTD PMID:24378259 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CTSB cathepsin B increases expression ISO 4-Aminopyridine results in increased expression of CTSB mRNA CTD PMID:24378259 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,448
Ensembl chr 8:11,842,524...11,869,448
JBrowse link
G DPYSL4 dihydropyrimidinase like 4 increases expression ISO 4-Aminopyridine results in increased expression of DPYSL4 mRNA CTD PMID:24378259 NCBI chr10:132,184,983...132,205,759
Ensembl chr10:132,186,948...132,205,759
JBrowse link
G GAD2 glutamate decarboxylase 2 increases expression
multiple interactions
ISO 4-Aminopyridine results in increased expression of GAD2 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]
CTD PMID:25917026 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558
JBrowse link
G GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 decreases expression ISO 4-Aminopyridine results in decreased expression of GALNT5 mRNA CTD PMID:24378259 NCBI chr 2:157,257,656...157,318,491
Ensembl chr 2:157,257,705...157,318,491
JBrowse link
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein CTD PMID:19911010 NCBI chr19:48,393,668...48,444,937
Ensembl chr19:48,394,875...48,444,931
JBrowse link
G HDAC5 histone deacetylase 5 multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein CTD PMID:15773917 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G JPH3 junctophilin 3 increases expression ISO 4-Aminopyridine results in increased expression of JPH3 mRNA CTD PMID:24378259 NCBI chr16:87,601,835...87,698,156
Ensembl chr16:87,601,835...87,698,156
JBrowse link
G KCNA10 potassium voltage-gated channel subfamily A member 10 multiple interactions EXP 4-Aminopyridine inhibits the reaction [KCNA10 protein results in increased transport of Potassium] CTD PMID:10836990 NCBI chr 1:110,517,217...110,519,175
Ensembl chr 1:110,517,217...110,519,175
JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 increases expression
multiple interactions
ISO 4-Aminopyridine results in increased expression of KCND3 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]
CTD PMID:25917026 NCBI chr 1:111,770,662...111,989,668
Ensembl chr 1:111,770,662...111,989,155
Ensembl chr 1:111,770,662...111,989,155
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP 4-Aminopyridine results in decreased activity of KCNH2 protein CTD PMID:19915712 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNIP1 potassium voltage-gated channel interacting protein 1 decreases expression
increases expression
multiple interactions
ISO 4-Aminopyridine results in decreased expression of KCNIP1 mRNA
4-Aminopyridine results in increased expression of KCNIP1 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]
CTD PMID:24378259 PMID:25917026 NCBI chr 5:170,353,055...170,736,632
Ensembl chr 5:170,353,487...170,736,632
JBrowse link
G MAG myelin associated glycoprotein decreases expression ISO 4-Aminopyridine results in decreased expression of MAG mRNA CTD PMID:24378259 NCBI chr19:35,292,161...35,313,807
Ensembl chr19:35,292,125...35,313,807
JBrowse link
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases expression ISO 4-Aminopyridine results in increased expression of MAP1LC3A mRNA CTD PMID:24378259 NCBI chr20:34,546,823...34,560,345
Ensembl chr20:34,546,854...34,560,345
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
4-Aminopyridine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]
CTD PMID:19911010 PMID:22759588 PMID:28132918 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
4-Aminopyridine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]
CTD PMID:19911010 PMID:22759588 PMID:28132918 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G NCOR2 nuclear receptor corepressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] CTD PMID:15773917 NCBI chr12:124,324,415...124,567,612
Ensembl chr12:124,324,415...124,567,589
JBrowse link
G RARA retinoic acid receptor alpha multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643
JBrowse link
G S100A7A S100 calcium binding protein A7A decreases expression ISO 4-Aminopyridine results in decreased expression of S100A7A mRNA CTD PMID:24378259 NCBI chr 1:153,416,520...153,423,222
Ensembl chr 1:153,416,520...153,423,222
JBrowse link
G SYN1 synapsin I affects response to substance
multiple interactions
increases response to substance
increases expression
ISO SYN1 protein affects the susceptibility to 4-Aminopyridine
ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]
SYN1 results in increased susceptibility to 4-Aminopyridine
CTD PMID:22759588 PMID:28132918 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857
JBrowse link
G TRAF2 TNF receptor associated factor 2 increases expression ISO 4-Aminopyridine results in increased expression of TRAF2 mRNA CTD PMID:24378259 NCBI chr 9:136,881,933...136,926,615
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
barium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO [barium chloride results in increased abundance of Barium] which results in decreased activity of ACHE protein CTD PMID:31407482 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ALB albumin multiple interactions
increases secretion
ISO Plant Extracts inhibits the reaction [barium chloride results in increased secretion of ALB protein] CTD PMID:26732703 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G CAT catalase multiple interactions
decreases activity
ISO [barium chloride results in increased abundance of Barium] which results in decreased activity of CAT protein; Plant Extracts inhibits the reaction [barium chloride results in decreased activity of CAT protein] CTD PMID:26732703 PMID:31407482 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions
ISO barium chloride results in increased expression of IL1B mRNA
Plant Extracts inhibits the reaction [barium chloride results in increased expression of IL1B mRNA]
CTD PMID:26732703 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
ISO barium chloride results in increased expression of IL6 mRNA
[barium chloride results in increased abundance of Barium] which results in increased expression of IL6 protein; Plant Extracts inhibits the reaction [barium chloride results in increased expression of IL6 mRNA]
CTD PMID:26732703 PMID:31407482 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 multiple interactions EXP barium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] CTD PMID:16909339 NCBI chr21:34,446,688...34,512,210
Ensembl chr21:34,446,688...34,512,210
JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 multiple interactions ISO barium chloride inhibits the reaction [KCNJ2 protein results in increased transport of Potassium] CTD PMID:11087224 NCBI chr17:70,169,532...70,180,044
Ensembl chr17:70,168,673...70,180,044
Ensembl chr17:70,168,673...70,180,044
JBrowse link
G KCNK3 potassium two pore domain channel subfamily K member 3 decreases activity ISO barium chloride results in decreased activity of KCNK3 protein CTD PMID:16020457 NCBI chr 2:26,692,722...26,733,420
Ensembl chr 2:26,692,690...26,733,420
JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 multiple interactions EXP barium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] CTD PMID:16909339 NCBI chr11:2,445,008...2,849,110
Ensembl chr11:2,444,684...2,849,105
Ensembl chr11:2,444,684...2,849,105
JBrowse link
G MT1A metallothionein 1A increases expression
multiple interactions
ISO barium chloride results in increased expression of MT1 mRNA
Plant Extracts inhibits the reaction [barium chloride results in increased expression of MT1 mRNA]
CTD PMID:26732703 NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
JBrowse link
G MT2A metallothionein 2A increases expression
multiple interactions
ISO barium chloride results in increased expression of MT2A mRNA
Plant Extracts inhibits the reaction [barium chloride results in increased expression of MT2A mRNA]
CTD PMID:26732703 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G SERPINE1 serpin family E member 1 increases secretion ISO barium chloride results in increased secretion of SERPINE1 protein CTD PMID:21596853 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SOD2 superoxide dismutase 2 decreases expression
multiple interactions
ISO barium chloride results in decreased expression of SOD2 mRNA
Plant Extracts inhibits the reaction [barium chloride results in decreased expression of SOD2 mRNA]
CTD PMID:26732703 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STX1A syntaxin 1A multiple interactions
affects localization
ISO Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]; STX1A protein modified form inhibits the reaction [Propofol inhibits the reaction [barium chloride affects the localization of STX1A protein]] CTD PMID:29320738 NCBI chr 7:73,699,210...73,719,673
Ensembl chr 7:73,699,206...73,719,672
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [barium chloride results in increased expression of TNF mRNA] CTD PMID:26732703 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TSC22D3 TSC22 domain family member 3 multiple interactions ISO [barium chloride results in increased abundance of Barium] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA] CTD PMID:29957541 NCBI chr  X:107,713,221...107,777,329
Ensembl chr  X:107,713,221...107,777,342
JBrowse link
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,347...75,787,575
JBrowse link
G ACAN aggrecan decreases expression EXP Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA] CTD PMID:29170048 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACOX1 acyl-CoA oxidase 1 multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACTA2 actin alpha 2, smooth muscle decreases expression ISO Berberine results in decreased expression of ACTA2 protein CTD PMID:17973934 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G AHR aryl hydrocarbon receptor increases activity ISO
EXP
Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein
CTD PMID:23954465 PMID:30138605 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AKT2 AKT serine/threonine kinase 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr19:40,230,317...40,285,531
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ALB albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AURKB aurora kinase B decreases expression EXP Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G AURKC aurora kinase C increases expression EXP Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr19:57,230,317...57,235,550
Ensembl chr19:57,230,802...57,235,548
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Niacinamide] results in increased expression of BAX protein; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]
CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression
multiple interactions
EXP Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA
CTD PMID:26712469 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]
CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions
increases expression
EXP [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA
CTD PMID:26712469 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression
multiple interactions
EXP Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]
CTD PMID:26478571 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 affects binding EXP Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
EXP
ISO
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA
CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 increases activity EXP Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases cleavage
multiple interactions
EXP
ISO
Berberine results in increased cleavage of CASP9 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein
CTD PMID:16505103 PMID:26712469 PMID:30138605 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein] CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein] CTD PMID:16391493 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 decreases expression EXP Berberine results in decreased expression of CCND1 protein CTD PMID:16505103 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 decreases expression EXP Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCNT1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr12:48,688,458...48,716,707
Ensembl chr12:48,688,458...48,716,998
JBrowse link
G CD36 CD36 molecule multiple interactions
increases expression
EXP
ISO
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein
CTD PMID:28038998 PMID:29408570 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CDH2 cadherin 2 decreases expression EXP Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:27,932,878...28,177,130
Ensembl chr18:27,932,879...28,177,946
Ensembl chr18:27,932,879...28,177,946
JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Berberine results in decreased expression of CDK4 protein CTD PMID:16505103 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,594
Ensembl chr 7:92,604,921...92,836,594
JBrowse link
G CDK9 cyclin dependent kinase 9 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 9:127,786,034...127,790,792
Ensembl chr 9:127,785,679...127,790,792
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C increases expression EXP Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr11:2,883,218...2,885,775
Ensembl chr11:2,883,213...2,885,775
Ensembl chr11:2,883,213...2,885,775
JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA
CTD PMID:20564506 PMID:26478571 NCBI chr19:33,299,934...33,302,564
Ensembl chr19:33,299,934...33,302,534
JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression
affects phosphorylation
multiple interactions
EXP
ISO
Berberine results in increased expression of CEBPB mRNA
Berberine affects the phosphorylation of CEBPB protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
CTD PMID:28038998 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CHEK1 checkpoint kinase 1 increases expression EXP Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr11:125,624,910...125,676,255
Ensembl chr11:125,625,665...125,676,255
JBrowse link
G CHEK2 checkpoint kinase 2 increases expression EXP Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G COL10A1 collagen type X alpha 1 chain increases expression EXP Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr 6:116,118,909...116,219,937
Ensembl chr 6:116,118,909...116,158,747
JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression EXP Berberine results in increased expression of COL1A1 mRNA CTD PMID:26478571 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression EXP Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREBBP CREB binding protein increases expression EXP Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CTNNB1 catenin beta 1 increases expression
multiple interactions
EXP Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]
CTD PMID:26478571 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493 PMID:28916288 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic affects localization EXP Berberine affects the localization of CYCS protein CTD PMID:16505103 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr10:102,830,531...102,837,413
Ensembl chr10:102,830,531...102,837,472
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA
CTD PMID:22342832 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
CTD PMID:22342832 PMID:25455889 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
decreases expression
decreases activity
EXP
ISO
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 mRNA]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]
Berberine results in decreased expression of CYP3A4 mRNA; Berberine results in decreased expression of CYP3A4 protein
CTD PMID:21524698 PMID:30086269 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DKK1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions EXP DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases expression EXP Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G DNMT3B DNA methyltransferase 3 beta decreases expression EXP Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr20:32,762,385...32,809,356
Ensembl chr20:32,762,385...32,809,356
JBrowse link
G DZIP3 DAZ interacting zinc finger protein 3 increases expression EXP Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr 3:108,589,490...108,694,840
Ensembl chr 3:108,589,705...108,694,840
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G EP300 E1A binding protein p300 increases expression EXP Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESRRA estrogen related receptor alpha multiple interactions EXP Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr11:64,305,524...64,316,743
Ensembl chr11:64,305,497...64,316,743
Ensembl chr11:64,305,497...64,316,743
JBrowse link
G FABP4 fatty acid binding protein 4 decreases expression
increases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]
CTD PMID:26478571 PMID:29408570 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
increases expression
ISO
EXP
[Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein
CTD PMID:20564506 PMID:20656010 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand increases expression EXP Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA] CTD PMID:30138605 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641
JBrowse link
G FOXO3 forkhead box O3 multiple interactions EXP [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G GDF5 growth differentiation factor 5 decreases expression EXP Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr20:35,433,347...35,454,749
Ensembl chr20:35,433,347...35,454,746
JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]
CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO
EXP
Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]
CTD PMID:20462044 PMID:23954465 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G H2AC11 H2A clustered histone 11 decreases expression EXP Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr 6:27,133,043...27,133,535
Ensembl chr 6:27,133,042...27,135,291
JBrowse link
G H2AC12 H2A clustered histone 12 decreases expression EXP Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr 6:27,147,106...27,147,562
Ensembl chr 6:27,147,129...27,147,515
Ensembl chr 6:27,147,129...27,147,515
JBrowse link
G H2AC14 H2A clustered histone 14 decreases expression EXP Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr 6:27,814,302...27,814,777
Ensembl chr 6:27,814,354...27,814,740
Ensembl chr 6:27,814,354...27,814,740
JBrowse link
G H2AC15 H2A clustered histone 15 decreases expression EXP Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr 6:27,837,880...27,838,375
Ensembl chr 6:27,837,947...27,838,339
Ensembl chr 6:27,837,947...27,838,339
JBrowse link
G H2AC17 H2A clustered histone 17 decreases expression EXP Berberine results in decreased expression of H2AC17 mRNA CTD PMID:27311644 NCBI chr 6:27,892,699...27,893,185
Ensembl chr 6:27,892,757...27,893,149
Ensembl chr 6:27,892,757...27,893,149
JBrowse link
G H2AC18 H2A clustered histone 18 decreases expression EXP Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 1:149,842,218...149,842,750
Ensembl chr 1:149,842,188...149,842,736
JBrowse link
G H2AC4 H2A clustered histone 4 decreases expression EXP Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr 6:26,033,092...26,033,618
Ensembl chr 6:26,033,176...26,033,568
Ensembl chr 6:26,033,176...26,033,568
JBrowse link
G H2AC6 H2A clustered histone 6 decreases expression EXP Berberine results in decreased expression of H2AC6 mRNA CTD PMID:27311644 NCBI chr 6:26,124,172...26,124,690
Ensembl chr 6:26,124,145...26,139,116
JBrowse link
G H2AC8 H2A clustered histone 8 decreases expression EXP Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr 6:26,216,921...26,217,483
Ensembl chr 6:26,216,975...26,217,483
JBrowse link
G H2AW H2A.W histone decreases expression EXP Berberine results in decreased expression of H2AW mRNA CTD PMID:27311644 NCBI chr 1:228,457,364...228,457,873
Ensembl chr 1:228,456,979...228,457,873
JBrowse link
G H2AX H2A.X variant histone increases expression
decreases expression
multiple interactions
EXP Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G H2BC11 H2B clustered histone 11 decreases expression EXP Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 6:27,132,316...27,132,795
Ensembl chr 6:27,125,897...27,132,750
Ensembl chr 6:27,125,897...27,132,750
JBrowse link
G H2BC12 H2B clustered histone 12 decreases expression EXP Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr 6:27,138,293...27,146,858
Ensembl chr 6:27,146,418...27,146,798
Ensembl chr 6:27,146,418...27,146,798
JBrowse link
G H2BC13 H2B clustered histone 13 decreases expression EXP Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr 6:27,807,479...27,807,929
Ensembl chr 6:27,807,444...27,807,931
JBrowse link
G H2BC14 H2B clustered histone 14 decreases expression EXP Berberine results in decreased expression of H2BC14 mRNA CTD PMID:27311644 NCBI chr 6:27,815,022...27,815,489
Ensembl chr 6:27,815,044...27,815,424
Ensembl chr 6:27,815,044...27,815,424
JBrowse link
G H2BC15 H2B clustered histone 15 decreases expression EXP Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr 6:27,838,569...27,839,110
Ensembl chr 6:27,837,760...27,865,798
JBrowse link
G H2BC17 H2B clustered histone 17 decreases expression EXP Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr 6:27,893,425...27,893,891
Ensembl chr 6:27,893,463...27,893,843
Ensembl chr 6:27,893,463...27,893,843
JBrowse link
G H2BC4 H2B clustered histone 4 decreases expression EXP Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr 6:26,113,170...26,123,926
Ensembl chr 6:26,114,873...26,123,926
JBrowse link
G H2BC5 H2B clustered histone 5 decreases expression EXP Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr 6:26,158,008...26,171,349
Ensembl chr 6:26,158,146...26,171,349
JBrowse link
G H2BC6 H2B clustered histone 6 decreases expression EXP Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr 6:26,183,761...26,184,230
Ensembl chr 6:26,172,059...26,184,655
JBrowse link
G H2BC7 H2B clustered histone 7 decreases expression EXP Berberine results in decreased expression of H2BC7 mRNA CTD PMID:27311644 NCBI chr 6:26,199,516...26,199,988
Ensembl chr 6:26,199,520...26,200,715
JBrowse link
G H2BC8 H2B clustered histone 8 decreases expression EXP Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr 6:26,216,200...26,216,688
Ensembl chr 6:26,215,159...26,216,692
JBrowse link
G H2BC9 H2B clustered histone 9 decreases expression EXP Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr 6:26,251,614...26,252,075
Ensembl chr 6:26,251,651...26,253,710
JBrowse link
G H2BW2 H2B.W histone 2 decreases expression EXP Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:104,039,753...104,042,454
Ensembl chr  X:104,039,916...104,042,454
Ensembl chr  X:104,039,916...104,042,454
JBrowse link
G H3-3A H3.3 histone A decreases expression EXP Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:226,061,831...226,072,019
Ensembl chr 1:226,061,851...226,073,212
Ensembl chr 1:226,061,851...226,073,212
Ensembl chr 1:226,061,851...226,073,212
JBrowse link
G H3-4 H3.4 histone decreases expression EXP Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,325
Ensembl chr 1:228,424,845...228,425,325
JBrowse link
G H3C1 H3 clustered histone 1 decreases expression EXP Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr 6:26,020,451...26,020,958
Ensembl chr 6:26,020,490...26,020,900
Ensembl chr 6:26,020,490...26,020,900
JBrowse link
G H3C10 H3 clustered histone 10 decreases expression EXP Berberine results in decreased expression of H3C10 mRNA CTD PMID:27311644 NCBI chr 6:27,810,051...27,810,536
Ensembl chr 6:27,810,064...27,811,300
JBrowse link
G H3C12 H3 clustered histone 12 decreases expression EXP Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr 6:27,890,315...27,890,826
Ensembl chr 6:27,890,382...27,893,106
Ensembl chr 6:27,890,382...27,893,106
JBrowse link
G H3C2 H3 clustered histone 2 decreases expression EXP Berberine results in decreased expression of H3C2 mRNA CTD PMID:27311644 NCBI chr 6:26,031,589...26,032,099
Ensembl chr 6:26,031,594...26,032,099
Ensembl chr 6:26,031,594...26,032,099
JBrowse link
G H3C4 H3 clustered histone 4 decreases expression EXP Berberine results in decreased expression of H3C4 mRNA CTD PMID:27311644 NCBI chr 6:26,196,784...26,199,293
Ensembl chr 6:26,196,840...26,197,250
Ensembl chr 6:26,196,840...26,197,250
JBrowse link
G H3C7 H3 clustered histone 7 decreases expression EXP Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr 6:26,250,142...26,250,635
Ensembl chr 6:26,250,195...26,250,605
Ensembl chr 6:26,250,195...26,250,605
JBrowse link
G H3C8 H3 clustered histone 8 decreases expression EXP Berberine results in decreased expression of H3C8 mRNA CTD PMID:27311644 NCBI chr 6:26,270,918...26,271,413
Ensembl chr 6:26,269,405...26,271,815
JBrowse link
G H4C14 H4 clustered histone 14 decreases expression EXP Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr 1:149,832,657...149,833,052
Ensembl chr 1:149,832,659...149,839,767
JBrowse link
G H4C2 H4 clustered histone 2 decreases expression EXP Berberine results in decreased expression of H4C2 mRNA CTD PMID:27311644 NCBI chr 6:26,026,896...26,027,283
Ensembl chr 6:26,026,815...26,027,252
JBrowse link
G H4C3 H4 clustered histone 3 decreases expression EXP Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr 6:26,103,933...26,104,337
Ensembl chr 6:26,103,876...26,104,310
Ensembl chr 6:26,103,876...26,104,310
JBrowse link
G H4C8 H4 clustered histone 8 decreases expression EXP Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr 6:26,285,126...26,285,534
Ensembl chr 6:26,277,609...26,285,638
JBrowse link
G H4C9 H4 clustered histone 9 decreases expression EXP Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr 6:27,139,282...27,139,678
Ensembl chr 6:27,138,588...27,139,881
JBrowse link
G HAT1 histone acetyltransferase 1 increases expression EXP Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:171,922,425...171,983,686
Ensembl chr 2:171,922,448...171,983,686
JBrowse link
G HDAC2 histone deacetylase 2 decreases expression EXP Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
JBrowse link
G HDAC5 histone deacetylase 5 increases expression EXP Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr17:44,076,753...44,123,651
Ensembl chr17:44,076,746...44,123,702
JBrowse link
G HDAC8 histone deacetylase 8 decreases expression EXP Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:72,329,516...72,573,099
Ensembl chr  X:72,329,516...72,573,101
JBrowse link
G HDAC9 histone deacetylase 9 decreases expression
increases expression
EXP Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA
CTD PMID:27311644 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416
JBrowse link
G HGF hepatocyte growth factor multiple interactions
increases expression
ISO
EXP
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein
CTD PMID:29408570 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP Berberine results in increased expression of HMOX1 protein
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]
CTD PMID:23954465 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha multiple interactions ISO Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]
CTD PMID:18563319 PMID:25455889 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression EXP Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945
JBrowse link
G IFNG interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1R insulin like growth factor 1 receptor multiple interactions
increases expression
EXP Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein
CTD PMID:23954465 NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530
JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression
ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA
CTD PMID:21867779 PMID:30138605 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO
Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]
CTD PMID:16391493 PMID:29170048 PMID:30138605 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 increases expression ISO Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL23A interleukin 23 subunit alpha multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr12:56,334,159...56,340,410
Ensembl chr12:56,334,174...56,340,410
JBrowse link
G IL4 interleukin 4 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA
CTD PMID:21867779 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO
EXP
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]
Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]
CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGA1 integrin subunit alpha 1 increases expression EXP Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr 5:52,787,916...52,959,209
Ensembl chr 5:52,787,916...52,959,209
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit affects localization
multiple interactions
ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]
CTD PMID:18294404 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions
ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]
CTD PMID:30086269 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KDM1A lysine demethylase 1A increases expression EXP Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
G KDM4A lysine demethylase 4A increases expression EXP Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 1:43,650,149...43,705,518
Ensembl chr 1:43,650,149...43,705,518
JBrowse link
G KDM5B lysine demethylase 5B increases expression EXP Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:202,724,495...202,809,470
Ensembl chr 1:202,724,495...202,808,487
Ensembl chr 1:202,724,495...202,808,487
JBrowse link
G KDM6A lysine demethylase 6A increases expression EXP Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:44,873,182...45,112,779
Ensembl chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
Ensembl chr  X:44,873,188...45,112,779
JBrowse link
G KDM6B lysine demethylase 6B increases expression EXP Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr17:7,834,210...7,854,796
Ensembl chr17:7,839,904...7,854,796
JBrowse link
G KMT5A lysine methyltransferase 5A increases expression EXP Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr12:123,384,132...123,409,353
Ensembl chr12:123,383,773...123,409,353
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]
CTD PMID:18640378 PMID:20564506 NCBI chr19:11,089,432...11,133,820
Ensembl chr19:11,089,462...11,133,820
Ensembl chr19:11,089,462...11,133,820
JBrowse link
G MAP3K5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr 6:136,557,046...136,793,098
Ensembl chr 6:136,557,046...136,792,477
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]
CTD PMID:18294404 PMID:20462044 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,551...46,028,334
Ensembl chr17:45,894,551...46,028,334
JBrowse link
G MCM2 minichromosome maintenance complex component 2 multiple interactions ISO Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 3:127,598,411...127,622,436
Ensembl chr 3:127,598,410...127,622,436
JBrowse link
G MIR19A microRNA 19a decreases expression EXP Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr13:91,350,891...91,350,972
Ensembl chr13:91,350,891...91,350,972
JBrowse link
G MIR92A1 microRNA 92a-1 decreases expression EXP Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391
JBrowse link
G MMP13 matrix metallopeptidase 13 increases expression EXP Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G MMP14 matrix metallopeptidase 14 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:22,836,585...22,847,758
Ensembl chr14:22,836,560...22,849,027
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]
CTD PMID:18294404 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,563,761...99,623,999
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
affects localization
ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase multiple interactions
decreases expression
EXP [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr 7:106,248,298...106,284,983
Ensembl chr 7:106,248,298...106,286,326
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
increases activity
multiple interactions
EXP
ISO
Berberine results in increased expression of NFE2L2 protein
Berberine results in increased activity of NFE2L2 protein
Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]
CTD PMID:23523906 PMID:23954465 PMID:30818834 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:21963898 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NGF nerve growth factor multiple interactions EXP Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]
CTD PMID:21095217 PMID:23523906 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver] RGD PMID:31432116 RGD:25823187 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:21524698 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G NSD2 nuclear receptor binding SET domain protein 2 decreases expression EXP Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 4:1,871,393...1,982,207
Ensembl chr 4:1,871,393...1,982,207
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions
decreases expression
ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OMD osteomodulin increases expression EXP Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr 9:92,412,380...92,424,471
Ensembl chr 9:92,414,245...92,424,461
JBrowse link
G P2RX7 purinergic receptor P2X 7 multiple interactions EXP Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr12:121,132,819...121,188,032
Ensembl chr12:121,132,819...121,188,032
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein
CTD PMID:16505103 PMID:26712469 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases response to substance
increases expression
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
PPARG mRNA results in increased susceptibility to Berberine
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine results in increased expression of PPARG mRNA
Berberine results in decreased expression of PPARG mRNA
CTD PMID:20564506 PMID:26478571 PMID:29408570 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRG4 proteoglycan 4 decreases expression EXP Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:186,296,273...186,314,567
Ensembl chr 1:186,296,279...186,314,562
Ensembl chr 1:186,296,279...186,314,562
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr 5:40,759,379...40,798,195
Ensembl chr 5:40,759,379...40,798,374
JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions
decreases activity
ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
G PRMT1 protein arginine methyltransferase 1 decreases expression EXP Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr19:49,676,166...49,688,447
Ensembl chr19:49,675,786...49,689,029
JBrowse link
G PRMT2 protein arginine methyltransferase 2 increases expression EXP Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr21:46,635,156...46,665,685
Ensembl chr21:46,635,595...46,665,124
JBrowse link
G PRMT5 protein arginine methyltransferase 5 increases expression EXP Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:22,920,526...22,929,392
Ensembl chr14:22,920,525...22,929,408
JBrowse link
G PRMT6 protein arginine methyltransferase 6 increases expression EXP Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 1:107,056,674...107,059,294
Ensembl chr 1:107,056,674...107,067,636
JBrowse link
G PRMT7 protein arginine methyltransferase 7 increases expression EXP Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr16:68,310,982...68,360,876
Ensembl chr16:68,310,974...68,358,584
Ensembl chr16:68,310,974...68,358,584
JBrowse link
G PRMT8 protein arginine methyltransferase 8 increases expression EXP Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr12:3,381,349...3,593,973
Ensembl chr12:3,381,349...3,593,973
JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases expression
ISO ((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]
Berberine results in increased expression of PTEN protein
CTD PMID:29408570 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RBP4 retinol binding protein 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr10:93,591,694...93,601,744
Ensembl chr10:93,591,687...93,601,744
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein] CTD PMID:23523906 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RLN1 relaxin 1 affects binding
increases expression
multiple interactions
ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA
CTD PMID:22363579 NCBI chr 9:5,334,930...5,339,876
Ensembl chr 9:5,334,930...5,339,876
JBrowse link
G RPS6 ribosomal protein S6 decreases phosphorylation EXP Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions
increases expression
EXP CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SETD1B SET domain containing 1B, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr12:121,803,665...121,832,656
Ensembl chr12:121,804,180...121,832,584
Ensembl chr12:121,804,180...121,832,584
JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 3:47,016,431...47,164,113
Ensembl chr 3:47,016,429...47,164,113
Ensembl chr 3:47,016,429...47,164,113
JBrowse link
G SETD3 SET domain containing 3, actin histidine methyltransferase increases expression EXP Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr14:99,397,746...99,486,458
Ensembl chr14:99,397,748...99,480,889
JBrowse link
G SETD5 SET domain containing 5 increases expression EXP Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 3:9,397,615...9,478,154
Ensembl chr 3:9,397,615...9,479,240
JBrowse link
G SETD6 SET domain containing 6, protein lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr16:58,515,479...58,523,842
Ensembl chr16:58,515,479...58,521,181
Ensembl chr16:58,515,479...58,521,181
JBrowse link
G SETD7 SET domain containing 7, histone lysine methyltransferase increases expression EXP Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 4:139,492,974...139,556,219
Ensembl chr 4:139,495,941...139,606,699
JBrowse link
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 increases expression EXP Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 1:150,926,263...150,964,737
Ensembl chr 1:150,926,263...150,964,744
JBrowse link
G SETDB2 SET domain bifurcated histone lysine methyltransferase 2 increases expression EXP Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr13:49,444,274...49,495,003
Ensembl chr13:49,444,374...49,495,003
JBrowse link
G SI sucrase-isomaltase decreases expression
multiple interactions
EXP
ISO
Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]
CTD PMID:20229011 NCBI chr 3:164,978,898...165,078,496
Ensembl chr 3:164,978,898...165,078,496
JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions
EXP Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]
CTD PMID:26712469 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 multiple interactions EXP [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SIRT3 sirtuin 3 multiple interactions
increases expression
decreases expression
EXP [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein
CTD PMID:26712469 PMID:27311644 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC27A5 solute carrier family 27 member 5 decreases expression EXP Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr19:58,498,333...58,512,028
Ensembl chr19:58,479,512...58,512,413
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SLC6A19 solute carrier family 6 member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr 5:1,201,595...1,225,111
Ensembl chr 5:1,201,595...1,225,111
JBrowse link
G SMYD3 SET and MYND domain containing 3 affects expression EXP Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:245,749,342...246,507,279
Ensembl chr 1:245,749,342...246,507,312
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA] CTD PMID:21095217 PMID:22775417 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]
CTD PMID:22775417 PMID:24751971 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression EXP Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416
JBrowse link
G SP7 Sp7 transcription factor increases expression EXP Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SPARC secreted protein acidic and cysteine rich increases expression EXP Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr 5:151,661,096...151,686,915
Ensembl chr 5:151,661,096...151,686,975
JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression
multiple interactions
EXP Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]
CTD PMID:26478571 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression
ISO
EXP
Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA
CTD PMID:20564506 PMID:26478571 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G TERT telomerase reverse transcriptase decreases activity EXP Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression
multiple interactions
ISO Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
CTD PMID:17973934 PMID:23523906 PMID:30138605 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA] CTD PMID:21963898 PMID:30240693 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
increases expression
EXP
ISO
Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 PMID:25600690 PMID:28533128 PMID:29170048 PMID:30240693 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TOP1 DNA topoisomerase I decreases activity EXP Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487
JBrowse link
G TOP2A DNA topoisomerase II alpha multiple interactions
affects response to substance
EXP TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine
CTD PMID:23747414 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein
CTD PMID:20656010 PMID:26712469 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRAF1 TNF receptor associated factor 1 increases expression EXP Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 9:120,902,393...120,929,171
Ensembl chr 9:120,902,393...120,929,173
JBrowse link
G TRAF2 TNF receptor associated factor 2 multiple interactions ISO Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 9:136,881,933...136,926,615
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
G TSTD1 thiosulfate sulfurtransferase like domain containing 1 increases expression EXP Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:161,037,631...161,038,964
Ensembl chr 1:161,037,631...161,038,977
JBrowse link
G UBE2A ubiquitin conjugating enzyme E2 A decreases expression EXP Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:119,574,563...119,584,423
Ensembl chr  X:119,574,536...119,591,083
JBrowse link
G UBE2B ubiquitin conjugating enzyme E2 B decreases expression EXP Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr 5:134,371,569...134,392,108
Ensembl chr 5:134,371,469...134,392,108
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA] CTD PMID:28533128 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G VEGFC vascular endothelial growth factor C increases expression EXP Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922
JBrowse link
dofetilide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FKBP1B FKBP prolyl isomerase 1B multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B mRNA]; dofetilide inhibits the reaction [Isoproterenol results in decreased expression of FKBP1B protein] CTD PMID:20723002 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects binding
EXP [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 protein; Acids inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; dofetilide analog inhibits the reaction [Astemizole binds to KCNH2 protein]; dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]; dofetilide binds to and results in decreased activity of KCNH2 protein; dofetilide inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium affects the reaction [dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]]; Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium promotes the reaction [dofetilide binds to KCNH2 protein] CTD PMID:9395068 PMID:10828461 PMID:15272206 PMID:15821840 PMID:15961988 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18701618 PMID:20071423 PMID:21158687 PMID:24052561 PMID:24200993 PMID:24830940 PMID:30561737 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G NCF2 neutrophil cytosolic factor 2 multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of NCF2 protein] CTD PMID:20723002 NCBI chr 1:183,555,562...183,590,914
Ensembl chr 1:183,555,563...183,590,876
Ensembl chr 1:183,555,563...183,590,876
JBrowse link
G PRKCE protein kinase C epsilon multiple interactions ISO dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE mRNA]; dofetilide inhibits the reaction [Isoproterenol results in increased expression of PRKCE protein] CTD PMID:20723002 NCBI chr 2:45,651,315...46,187,990
Ensembl chr 2:45,651,345...46,187,990
JBrowse link
ezogabine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C affects activity EXP ezogabine affects the activity of CACNA1C protein CTD PMID:28641963 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,786...2,697,950
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 affects activity EXP ezogabine affects the activity of KCNH2 protein CTD PMID:28641963 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 multiple interactions
affects activity
ISO
EXP
ezogabine affects the reaction [[Potassium results in increased activity of KCNQ2 protein] which results in increased import of Thallium]
ezogabine affects the activity of KCNQ2 protein
CTD PMID:15634793 PMID:26627826 NCBI chr20:63,400,208...63,472,655
Ensembl chr20:63,400,210...63,472,677
Ensembl chr20:63,400,210...63,472,677
JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 decreases response to substance
affects activity
EXP KCNQ3 protein mutant form results in decreased susceptibility to ezogabine
ezogabine affects the activity of KCNQ3 protein
CTD PMID:26627826 NCBI chr 8:132,120,858...132,481,095
Ensembl chr 8:132,120,859...132,481,095
JBrowse link
G KCNQ4 potassium voltage-gated channel subfamily Q member 4 multiple interactions
increases activity
EXP [ezogabine results in increased activity of KCNQ4 protein] which results in increased export of Rubidium; [ezogabine results in increased activity of KCNQ4 protein] which results in increased import of Thallium CTD PMID:16904708 PMID:21782781 NCBI chr 1:40,783,787...40,840,457
Ensembl chr 1:40,783,787...40,840,452
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 affects activity EXP ezogabine affects the activity of SCN5A protein CTD PMID:28641963 NCBI chr 3:38,548,061...38,649,687
Ensembl chr 3:38,548,057...38,649,687
Ensembl chr 3:38,548,057...38,649,687
JBrowse link
nicorandil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC9 ATP binding cassette subfamily C member 9 increases activity ISO Nicorandil results in increased activity of ABCC9 protein CTD PMID:22622455 NCBI chr12:21,797,389...21,941,863
Ensembl chr12:21,797,401...21,942,529
JBrowse link
G AGT angiotensinogen multiple interactions ISO Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein] CTD PMID:22622455 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of BAX protein] CTD PMID:31376360 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] CTD PMID:31376360 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CAT catalase multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:31376360 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CTSD cathepsin D multiple interactions ISO [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of CTSD protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of CTSD protein] CTD PMID:11829124 PMID:14499179 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G GAL galanin and GMAP prepropeptide multiple interactions ISO [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in decreased activity of GAL protein]; [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GAL protein] CTD PMID:11829124 PMID:14499179 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GUSB glucuronidase beta multiple interactions ISO [Nicorandil co-treated with Amlodipine] inhibits the reaction [Isoproterenol results in increased activity of GUSB protein] CTD PMID:11829124 PMID:14499179 NCBI chr 7:65,960,684...65,982,230
Ensembl chr 7:65,960,684...65,982,215
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of HAVCR1 protein] CTD PMID:31376360 NCBI chr 5:157,028,383...157,069,633
Ensembl chr 5:157,029,413...157,059,119
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression ISO Nicorandil results in decreased expression of HMOX1 protein CTD PMID:22622455 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of IL1B protein] CTD PMID:31376360 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G MPO myeloperoxidase multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of MPO protein] CTD PMID:31376360 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein] CTD PMID:31376360 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of NFKB1 protein] CTD PMID:31376360 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G SOD2 superoxide dismutase 2 increases expression ISO Nicorandil results in increased expression of SOD2 protein CTD PMID:22622455 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TLR4 protein] CTD PMID:31376360 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Nicorandil inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:31376360 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G XDH xanthine dehydrogenase multiple interactions
decreases expression
ISO Nicorandil inhibits the reaction [AGT protein modified form results in increased expression of XDH protein]
Nicorandil results in decreased expression of XDH protein
CTD PMID:22622455 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
NS 1619 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions EXP NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]] CTD PMID:21413024 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G FLT1 fms related receptor tyrosine kinase 1 multiple interactions EXP NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]; paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]] CTD PMID:25371888 NCBI chr13:28,300,346...28,495,128
Ensembl chr13:28,300,346...28,495,145
JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions EXP NS 1619 binds to and results in increased activity of KCNMA1 protein; NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr10:76,869,602...77,637,969
Ensembl chr10:76,869,601...77,638,369
JBrowse link
G KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 multiple interactions EXP NS 1619 inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; NS 1619 inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]] CTD PMID:21413024 NCBI chr 5:170,374,671...170,389,367
Ensembl chr 5:170,374,671...170,389,634
JBrowse link
quinidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects transport
increases transport
affects binding
affects response to substance
decreases expression
multiple interactions
EXP
ISO
ABCB1 protein affects the transport of Quinidine
ABCB1 protein results in increased transport of Quinidine
Quinidine binds to ABCB1 protein
ABCB1A protein affects the susceptibility to Quinidine
Quinidine results in decreased expression of ABCB1 protein
methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of Quinidine]
CTD PMID:15502009 PMID:15616150 PMID:20196146 PMID:23976943 PMID:26995013 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ACADM acyl-CoA dehydrogenase medium chain decreases expression ISO Quinidine results in decreased expression of ACADM mRNA CTD PMID:17522070 NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,347...75,787,575
JBrowse link
G ADRA1A adrenoceptor alpha 1A affects binding
multiple interactions
EXP Quinidine binds to ADRA1A protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr 8:26,738,113...26,870,994
Ensembl chr 8:26,748,150...26,867,278
JBrowse link
G ADRA1B adrenoceptor alpha 1B affects binding
multiple interactions
EXP Quinidine binds to ADRA1B protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr 5:159,916,482...159,989,205
Ensembl chr 5:159,865,080...159,973,012
JBrowse link
G ADRA1D adrenoceptor alpha 1D affects binding
multiple interactions
EXP Quinidine binds to ADRA1D protein
[Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]; Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate]
CTD PMID:9570190 NCBI chr20:4,220,630...4,249,287
Ensembl chr20:4,220,630...4,249,287
JBrowse link
G ALDOA aldolase, fructose-bisphosphate A increases expression ISO Quinidine results in increased expression of ALDOA mRNA CTD PMID:17522070 NCBI chr16:30,064,279...30,070,420
Ensembl chr16:30,064,164...30,070,457
Ensembl chr16:30,064,164...30,070,457
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Quinidine results in increased expression of ASNS mRNA CTD PMID:15342952 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G CAT catalase increases expression ISO Quinidine results in increased expression of CAT protein CTD PMID:12708743 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Quinidine results in increased expression of CDKN1A protein CTD PMID:12243503 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 increases expression ISO Quinidine results in increased expression of CEACAM1 mRNA CTD PMID:17522070 NCBI chr19:42,507,306...42,528,482
Ensembl chr19:42,507,304...42,561,234
JBrowse link
G CYB5R3 cytochrome b5 reductase 3 decreases expression ISO Quinidine results in decreased expression of CYB5R3 mRNA CTD PMID:17522070 NCBI chr22:42,617,840...42,649,392
Ensembl chr22:42,617,840...42,649,392
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases activity
EXP
ISO
Quinidine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Quinidine results in decreased activity of CYP1A1 protein
CTD PMID:18420780 PMID:18493746 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions
decreases activity
EXP Quinidine affects the reaction [CYP1A2 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP1A2 protein
CTD PMID:15916432 PMID:19053182 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity ISO Quinidine results in decreased activity of CYP1B1 protein CTD PMID:18420780 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A7 cytochrome P450 family 2 subfamily A member 7 decreases activity ISO Quinidine results in decreased activity of CYP2A4 protein CTD PMID:18420780 NCBI chr19:40,875,439...40,885,951
Ensembl chr19:40,875,439...40,882,752
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 decreases activity ISO Quinidine results in decreased activity of CYP2B10 protein CTD PMID:18420780 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
decreases activity
EXP
ISO
Quinidine affects the reaction [CYP2C19 protein results in increased oxidation of 4-amino-2-phenoxymethanesulfonanilide]
Quinidine results in decreased activity of CYP2C6V1 protein
CTD PMID:12814958 PMID:19053182 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity ISO Quinidine results in decreased activity of CYP2C29 protein CTD PMID:18420780 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity ISO Quinidine results in decreased activity of CYP2C9 protein CTD PMID:18420780 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 increases metabolic processing
decreases activity
multiple interactions
EXP
ISO
CYP2D6 protein results in increased metabolism of Quinidine
Quinidine results in decreased activity of CYP2D6 protein
[Quinidine results in decreased activity of CYP2D6 protein] which results in decreased glutathionylation of Duloxetine Hydrochloride
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of 4-hydroxy-N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased hydroxylation of N-desmethyltamoxifen; [Quinidine results in decreased activity of CYP2D6 protein] which results in decreased metabolism of Dextromethorphan; Quinidine binds to and results in decreased activity of CYP2D6 protein; Quinidine inhibits the reaction [3-(2-(N,N-diethyl-N-methylammonium)ethyl)-7-methoxy-4-methylcoumarin results in increased metabolism of CYP2D6 protein]; Quinidine inhibits the reaction [[CYP2D6 protein results in increased metabolism of 7-methoxy-4-(aminomethyl)coumarin] which results in increased chemical synthesis of Coumarins]; Quinidine inhibits the reaction [CYP2D6 protein affects the metabolism of 1-(3-chlorophenyl)piperazine]; Quinidine inhibits the reaction [CYP2D6 protein results in increased chemical synthesis of Dextrorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased hydrolysis of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of bufuralol]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of tegaserod]; Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein]
Quinidine results in decreased activity of CYP2D6 gene mutant form; Quinidine results in decreased activity of CYP2D6 protein
CTD PMID:8819299 PMID:11377097 PMID:11560869 PMID:11673748 PMID:12464242 PMID:12467917 PMID:12569440 PMID:12814958 PMID:14652237 PMID:15155557 PMID:15306208 PMID:15860655 PMID:16035375 PMID:16595712 PMID:17702393 PMID:18238857 PMID:18420780 PMID:19230594 PMID:19328226 PMID:20345925 PMID:20590588 PMID:20669986 PMID:21277363 PMID:21336516 PMID:21915887 PMID:23850985 PMID:24167220 PMID:26599973 PMID:28119166 PMID:28887089 PMID:31515991 PMID:32198085 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity ISO Quinidine results in decreased activity of CYP2E1 protein CTD PMID:18420780 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects metabolic processing
multiple interactions
EXP CYP3A4 protein affects the metabolism of Quinidine
Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758]; Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CTD PMID:2271712 PMID:15784650 PMID:19230594 PMID:19299527 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DEPP1 DEPP1 autophagy regulator increases expression EXP Quinidine results in increased expression of DEPP1 mRNA CTD PMID:17567588 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Quinidine results in increased expression of FABP1 mRNA CTD PMID:17567588 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FGA fibrinogen alpha chain increases expression ISO Quinidine results in increased expression of FGA mRNA CTD PMID:17522070 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,128...154,590,745
JBrowse link
G FGB fibrinogen beta chain increases expression ISO Quinidine results in increased expression of FGB mRNA CTD PMID:17522070 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807
Ensembl chr 4:154,563,011...154,572,807
JBrowse link
G GSTM1 glutathione S-transferase mu 1 decreases activity EXP Quinidine results in decreased activity of GSTM1 protein CTD PMID:11807801 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM3 glutathione S-transferase mu 3 decreases expression ISO Quinidine results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
decreases activity
EXP Quinidine inhibits the reaction [GSTP1 protein affects the metabolism of and results in decreased activity of Ethacrynic Acid]
Quinidine results in decreased activity of GSTP1 protein
CTD PMID:11807801 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G HIBADH 3-hydroxyisobutyrate dehydrogenase increases expression ISO Quinidine results in increased expression of HIBADH mRNA CTD PMID:17522070 NCBI chr 7:27,525,440...27,662,903
Ensembl chr 7:27,525,442...27,662,883
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions EXP Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G INHBE inhibin subunit beta E increases expression EXP Quinidine results in increased expression of INHBE mRNA CTD PMID:15342952 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
JBrowse link
G KCNH1 potassium voltage-gated channel subfamily H member 1 multiple interactions EXP Quinidine inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein] CTD PMID:17520698 NCBI chr 1:210,678,314...211,134,148
Ensembl chr 1:210,676,823...211,134,165
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects activity
affects binding
affects localization
affects response to substance
decreases response to substance
EXP [Quinidine results in decreased activity of KCNH2 protein] which results in decreased import of Thallium; Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]
Quinidine affects the activity of KCNH2 protein
Quinidine binds to KCNH2 protein
Quinidine affects the localization of KCNH2 protein mutant form
KCNH2 gene SNP affects the susceptibility to Quinidine
KCNH2 gene mutant form results in decreased susceptibility to Quinidine
CTD PMID:11741928 PMID:12695533 PMID:15671647 PMID:15673388 PMID:15821840 PMID:16960444 PMID:17042915 PMID:18057881 PMID:18701618 PMID:18724381 PMID:19583963 PMID:21158687 PMID:21362439 PMID:22020101 PMID:24052561 PMID:28551711 NCBI chr 7:150,944,956...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 multiple interactions ISO Quinidine affects the reaction [KCNK1 protein results in increased transport of Potassium]; Quinidine inhibits the reaction [KCNK1 protein results in increased transport of Sodium] CTD PMID:16847696 NCBI chr 1:233,614,106...233,672,514
Ensembl chr 1:233,614,106...233,672,514
JBrowse link
G KCNK18 potassium two pore domain channel subfamily K member 18 multiple interactions EXP Quinidine inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr10:117,197,489...117,210,299
Ensembl chr10:117,197,489...117,210,299
JBrowse link
G KCNK9 potassium two pore domain channel subfamily K member 9 multiple interactions ISO Quinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:10734076 NCBI chr 8:139,600,838...139,703,135
Ensembl chr 8:139,600,838...139,704,109
JBrowse link
G LBP lipopolysaccharide binding protein increases expression ISO Quinidine results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr20:38,346,482...38,377,013
Ensembl chr20:38,346,482...38,377,013
JBrowse link
G LIPC lipase C, hepatic type decreases expression ISO Quinidine results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr15:58,410,457...58,569,844
Ensembl chr15:58,410,569...58,569,844
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression ISO Quinidine results in decreased expression of MYC mRNA CTD PMID:17522070 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression EXP Quinidine results in increased expression of NUPR1 mRNA CTD PMID:17567588 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,174
Ensembl chr16:28,532,708...28,539,174
JBrowse link
G OTC ornithine transcarbamylase decreases expression ISO Quinidine results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:38,352,528...38,421,446
Ensembl chr  X:38,352,586...38,421,446
JBrowse link
G PKLR pyruvate kinase L/R decreases expression ISO Quinidine results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 1:155,289,293...155,301,438
Ensembl chr 1:155,289,293...155,301,438
JBrowse link
G PTMA prothymosin alpha decreases expression ISO Quinidine results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 2:231,708,525...231,713,551
Ensembl chr 2:231,706,895...231,713,541
Ensembl chr 2:231,706,895...231,713,541
JBrowse link
G S100A9 S100 calcium binding protein A9 increases expression ISO Quinidine results in increased expression of S100A9 mRNA CTD PMID:17522070 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 affects response to substance ISO SCN5A gene mutant form affects the susceptibility to Quinidine CTD PMID:17805561 NCBI chr 3:38,548,061...38,649,687
Ensembl chr 3:38,548,057...38,649,687
Ensembl chr 3:38,548,057...38,649,687
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions ISO
EXP
[Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Phenylephrine; [Quinidine analog results in decreased activity of SLC22A1 protein] which results in decreased import of Synephrine
Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Quercetin]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of retrorsine]
CTD PMID:16141367 PMID:21140131 PMID:23831208 PMID:24799337 PMID:24947867 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:16141367 PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC22A3 solute carrier family 22 member 3 multiple interactions EXP Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 NCBI chr 6:160,348,378...160,454,982
Ensembl chr 6:160,348,378...160,452,577
JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases expression EXP Quinidine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...7,936,187
JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity
multiple interactions
EXP Quinidine results in decreased activity of SLC47A1 protein
Quinidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16928787 PMID:22419765 NCBI chr17:19,533,854...19,579,034
Ensembl chr17:19,495,385...19,579,034
JBrowse link
G SLC47A2 solute carrier family 47 member 2 multiple interactions EXP Quinidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr17:19,678,313...19,719,598
Ensembl chr17:19,678,288...19,718,979
JBrowse link
G TAGLN transgelin decreases expression EXP Quinidine results in decreased expression of TAGLN mRNA CTD PMID:17567588 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression ISO Quinidine results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:47,582,408...47,586,789
Ensembl chr  X:47,582,408...47,586,789
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A decreases expression ISO Quinidine results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFRSF8 TNF receptor superfamily member 8 decreases expression EXP Quinidine results in decreased expression of TNFRSF8 protein CTD PMID:12441127 NCBI chr 1:12,063,303...12,144,213
Ensembl chr 1:12,063,303...12,144,207
JBrowse link
G TP53 tumor protein p53 decreases expression ISO Quinidine results in decreased expression of TP53 mRNA CTD PMID:17522070 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
tolbutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases activity
multiple interactions
EXP Tolbutamide results in decreased activity of ABCB1 protein
Tolbutamide inhibits the reaction [ABCB1 protein results in increased uptake of quinidinium]
CTD PMID:32305507 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein]; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein] CTD PMID:9568693 PMID:18025464 PMID:22209866 NCBI chr11:17,392,498...17,476,849
Ensembl chr11:17,392,498...17,476,879
JBrowse link
G ALB albumin affects binding EXP Tolbutamide binds to ALB protein CTD PMID:19596536 PMID:20435530 PMID:20956006 PMID:20974553 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G CCND1 cyclin D1 increases expression ISO Tolbutamide results in increased expression of CCND1 protein CTD PMID:16718685 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND3 cyclin D3 increases expression ISO Tolbutamide results in increased expression of CCND3 protein CTD PMID:16718685 NCBI chr 6:41,934,933...42,048,894
Ensembl chr 6:41,934,933...42,050,357
Ensembl chr 6:41,934,933...42,050,357
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein] CTD PMID:16718685 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression ISO Tolbutamide results in increased expression of CDKN1B protein CTD PMID:16718685 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 increases metabolic processing
multiple interactions
EXP
ISO
CYP2C18 results in increased metabolism of Tolbutamide
[CYP2C55 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:15301741 PMID:30503582 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases metabolic processing
increases hydroxylation
multiple interactions
EXP CYP2C19 protein results in increased metabolism of Tolbutamide
CYP2C19 protein results in increased hydroxylation of Tolbutamide
[CYP2C19 protein results in increased hydroxylation of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CTD PMID:18511451 PMID:30500380 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C23P cytochrome P450 family 2 subfamily C member 23, pseudogene multiple interactions
increases metabolic processing
ISO [CYP2C23 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide CTD PMID:30503582 NCBI chr10:100,105,754...100,140,151
Ensembl chr10:100,105,754...100,140,151
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases hydroxylation EXP CYP2C8 protein results in increased hydroxylation of Tolbutamide CTD PMID:15843491 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions
increases metabolic processing
increases hydroxylation
increases chemical synthesis
affects metabolic processing
affects hydroxylation
decreases hydroxylation
decreases metabolic processing
increases hydrolysis
EXP
ISO
[CYP2C9 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide; Acetone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; acetonitrile promotes the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 gene mutant form inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; CYP2C9 protein binds to and affects the metabolism of Tolbutamide; Fenitrothion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; phenthoate inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; pranlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; profenofos inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased hydrolysis of Tolbutamide]; Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Ticlopidine inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]; Tolbutamide inhibits the reaction [CYP2C9 protein affects the metabolism of Diclofenac]; zafirlukast inhibits the reaction [CYP2C9 protein results in increased metabolism of Tolbutamide]
CYP2C66 protein results in increased metabolism of Tolbutamide
[CYP2C66 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C65 protein results in increased metabolism of Tolbutamide
[CYP2C65 protein results in increased metabolism of Tolbutamide] which results in increased chemical synthesis of 4'-hydroxytolbutamide
CYP2C9 protein results in increased chemical synthesis of Tolbutamide metabolite
CYP2C9 gene polymorphism affects the metabolism of Tolbutamide; CYP2C9 gene SNP affects the metabolism of Tolbutamide; CYP2C9 protein affects the metabolism of Tolbutamide
CYP2C9 protein affects the hydroxylation of Tolbutamide
CYP2C9 gene SNP results in decreased hydroxylation of Tolbutamide
CYP2C9 gene polymorphism results in decreased metabolism of Tolbutamide
CTD PMID:2025243 PMID:9110362 PMID:9170147 PMID:9522436 PMID:10208645 PMID:10611138 PMID:11377097 PMID:11875364 PMID:12426520 PMID:12433797 PMID:12464242 PMID:12467917 PMID:15045499 PMID:15155557 PMID:15327588 PMID:15370959 PMID:15626586 PMID:15843491 PMID:15856409 PMID:16081671 PMID:16124035 PMID:17267297 PMID:17565714 PMID:17702393 PMID:19082874 PMID:19715737 PMID:21915887 PMID:22634058 PMID:23850985 PMID:25994031 PMID:26255664 PMID:26763401 PMID:30503582 PMID:32198085 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G GCG glucagon increases secretion ISO Tolbutamide results in increased secretion of GCG protein CTD PMID:15919803 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions
increases expression
ISO GJA1 promotes the reaction [Tolbutamide results in increased expression of CDKN1A protein]; Tolbutamide promotes the reaction [Bucladesine results in increased expression of GJA1 protein]
Tolbutamide results in increased expression of GJA1 protein
CTD PMID:11741589 PMID:16718685 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G HK1 hexokinase 1 increases expression ISO Tolbutamide results in increased expression of HK1 protein CTD PMID:11835228 NCBI chr10:69,269,991...69,401,882
Ensembl chr10:69,269,984...69,401,884
JBrowse link
G INS insulin multiple interactions
increases secretion
EXP ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9032110 PMID:9568693 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 multiple interactions
decreases activity
EXP [KCNJ11 mutant form co-treated with ABCC8 mutant form] results in decreased susceptibility to Tolbutamide; Tolbutamide inhibits the reaction [ABCC8 protein mutant form results in increased activity of KCNJ11 protein]
Tolbutamide results in decreased activity of KCNJ11 protein
CTD PMID:18025464 PMID:22209866 NCBI chr11:17,385,246...17,389,346
Ensembl chr11:17,385,859...17,389,331
JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression ISO Tolbutamide results in decreased expression of MKI67 protein CTD PMID:16718685 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423
JBrowse link
G PDCD4 programmed cell death 4 decreases expression
increases expression
EXP Tolbutamide results in decreased expression of PDCD4 mRNA
Tolbutamide results in increased expression of PDCD4 mRNA
CTD PMID:21873647 NCBI chr10:110,871,928...110,900,006
Ensembl chr10:110,871,795...110,900,006
JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation ISO Tolbutamide results in decreased phosphorylation of RB1 protein CTD PMID:16718685 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression ISO Tolbutamide results in increased expression of SLC2A1 mRNA; Tolbutamide results in increased expression of SLC2A1 protein CTD PMID:2682625 PMID:11835228 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
Ensembl chr 1:42,925,353...42,958,893
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 decreases expression EXP Tolbutamide results in decreased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TP53 tumor protein p53 increases expression ISO Tolbutamide results in increased expression of TP53 mRNA CTD PMID:16426753 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPD52 tumor protein D52 decreases expression
increases expression
EXP Tolbutamide results in decreased expression of TPD52 mRNA
Tolbutamide results in increased expression of TPD52 mRNA
CTD PMID:21873647 NCBI chr 8:79,918,717...80,171,564
Ensembl chr 8:80,034,745...80,231,232
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase decreases expression ISO Tolbutamide results in decreased expression of UGDH protein CTD PMID:4270849 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311
JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases expression ISO Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 affects expression ISO Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr 8:142,910,559...142,917,843
Ensembl chr 8:142,910,559...142,917,843
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions
increases metabolic processing
EXP Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]
CYP2C8 protein results in increased metabolism of Torsemide
CTD PMID:15304522 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases hydroxylation
affects metabolic processing
increases metabolic processing
EXP
ISO
CYP2C9 protein results in increased hydroxylation of Torsemide
CYP2C11 protein affects the metabolism of Torsemide
CYP2C9 protein results in increased metabolism of Torsemide
CTD PMID:9110362 PMID:15890479 PMID:19082874 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G NPPA natriuretic peptide A decreases expression ISO Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions ISO Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr 4:148,078,764...148,444,698
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G REN renin increases expression ISO Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324
JBrowse link
G SLC12A2 solute carrier family 12 member 2 multiple interactions
decreases activity
EXP Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
Torsemide results in decreased activity of SLC12A2 protein
CTD PMID:29959396 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
G TGFB1 transforming growth factor beta 1 affects expression
decreases expression
ISO Torsemide affects the expression of TGFB1 protein
Torsemide results in decreased expression of TGFB1 protein
CTD PMID:18001696 PMID:18154949 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
trans-piceid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects export EXP ABCC2 protein affects the export of polydatin CTD PMID:15686436 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G AGT angiotensinogen multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of MYH7 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein] CTD PMID:25488910 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AHR aryl hydrocarbon receptor decreases localization
multiple interactions
EXP polydatin results in decreased localization of AHR protein
polydatin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
CTD PMID:21756928 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator increases localization EXP polydatin results in increased localization of ARNT protein CTD PMID:21756928 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO
EXP
cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of BCL2 mRNA]
polydatin inhibits the reaction [Dopamine results in decreased expression of BCL2 protein]
CTD PMID:27481074 PMID:28980048 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CAT catalase multiple interactions ISO cyclopamine inhibits the reaction [polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]]; polydatin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased activity of CAT protein]
polydatin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]
CTD PMID:27481074 PMID:29130132 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
decreases secretion
decreases expression
EXP polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; polydatin inhibits the reaction [PD168393 results in increased expression of CCL2 mRNA]
polydatin results in decreased secretion of CCL2 protein
polydatin results in decreased expression of CCL2 mRNA
CTD PMID:21756928 PMID:21967610 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCND1 cyclin D1 multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA] CTD PMID:27481074 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND2 mRNA] CTD PMID:27481074 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions
decreases secretion
decreases expression
EXP [polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin inhibits the reaction [PD168393 results in increased expression of CXCL10 mRNA]
polydatin results in decreased secretion of CXCL10 protein
polydatin results in decreased expression of CXCL10 mRNA
CTD PMID:21756928 PMID:21967610 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases secretion
decreases expression
EXP [polydatin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
polydatin results in increased secretion of CXCL8 protein
polydatin results in decreased expression of CXCL8 mRNA
CTD PMID:21756928 PMID:21967610 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of CYBB protein] CTD PMID:25488910 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression EXP polydatin results in increased expression of CYP1A1 mRNA CTD PMID:21756928 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP polydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21967610 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G ESR2 estrogen receptor 2 multiple interactions ISO ESR2 gene mutant form inhibits the reaction [polydatin results in increased expression of SOD2 protein] CTD PMID:24361291 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase decreases activity EXP polydatin results in decreased activity of G6PD protein CTD PMID:25130191 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GLI1 GLI family zinc finger 1 multiple interactions ISO cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]]; cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein]]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of GLI1 mRNA]; polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased localization of GLI1 protein] CTD PMID:27481074 NCBI chr12:57,459,785...57,472,451
Ensembl chr12:57,459,785...57,472,268
JBrowse link
G HLCS holocarboxylase synthetase decreases activity EXP polydatin results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr21:36,748,625...36,990,255
Ensembl chr21:36,748,626...36,990,236
Ensembl chr21:36,748,626...36,990,236
JBrowse link
G IFNG interferon gamma multiple interactions EXP polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein] CTD PMID:21756928 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B mRNA] CTD PMID:29130132 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL4 interleukin 4 multiple interactions ISO polydatin inhibits the reaction [OVAL protein results in increased secretion of IL4 protein] CTD PMID:23840142 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression
EXP polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
polydatin results in decreased expression of IL6 mRNA
CTD PMID:21756928 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions EXP
ISO
polydatin inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]
polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein]
CTD PMID:31705858 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G LCT lactase increases hydrolysis ISO LCT protein results in increased hydrolysis of polydatin analog CTD PMID:17009167 NCBI chr 2:135,787,850...135,837,195
Ensembl chr 2:135,787,850...135,837,184
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
EXP polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [polydatin results in increased phosphorylation of MAPK1 protein]
polydatin results in decreased phosphorylation of MAPK1 protein
CTD PMID:21756928 PMID:28980048 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation
EXP polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [polydatin results in increased phosphorylation of MAPK3 protein]
polydatin results in decreased phosphorylation of MAPK3 protein
CTD PMID:21756928 PMID:28980048 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK7 mitogen-activated protein kinase 7 multiple interactions
increases phosphorylation
EXP XMD 8-92 inhibits the reaction [polydatin results in increased phosphorylation of MAPK7 protein] CTD PMID:28980048 NCBI chr17:19,377,721...19,383,544
Ensembl chr17:19,377,721...19,383,544
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of MYH7 mRNA] CTD PMID:25488910 NCBI chr14:23,412,740...23,435,677
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP
ISO
[polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein; NFE2L2 protein affects the reaction [[polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]
polydatin inhibits the reaction [TSHR protein results in decreased expression of NFE2L2 protein]
CTD PMID:31705858 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 mRNA]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NOX4 protein] CTD PMID:25488910 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased expression of NPPA protein]; polydatin inhibits the reaction [AGT protein modified form results in increased expression of NPPA mRNA]; polydatin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:25449040 PMID:25488910 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO
NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]; polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]
polydatin inhibits the reaction [TSHR protein results in decreased expression of NQO1 protein]
CTD PMID:31705858 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G ORAI1 ORAI calcium release-activated calcium modulator 1 affects response to substance ISO ORAI1 protein affects the susceptibility to polydatin CTD PMID:22959927 NCBI chr12:121,626,550...121,642,040
Ensembl chr12:121,626,550...121,642,677
JBrowse link
G PDE5A phosphodiesterase 5A decreases activity EXP polydatin results in decreased activity of PDE5A protein CTD PMID:15769121 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804
JBrowse link
G PPP1R12A protein phosphatase 1 regulatory subunit 12A multiple interactions ISO polydatin inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of PPP1R12A protein]; polydatin inhibits the reaction [Phenylephrine results in increased phosphorylation of PPP1R12A protein] CTD PMID:25449040 NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity ISO polydatin results in decreased activity of PTGS1 protein CTD PMID:11962253 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity
EXP
ISO
[polydatin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA
polydatin results in decreased activity of PTGS2 protein
CTD PMID:11962253 PMID:21756928 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA mRNA]
CTD PMID:21756928 PMID:29130132 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RHOA ras homolog family member A multiple interactions ISO polydatin inhibits the reaction [Phenylephrine results in increased activity of RHOA protein] CTD PMID:25449040 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,145...49,412,998
Ensembl chr 3:49,359,145...49,412,998
JBrowse link
G SHH sonic hedgehog signaling molecule multiple interactions ISO polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and results in increased secretion of SHH protein] CTD PMID:27481074 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463
JBrowse link
G SLC22A1 solute carrier family 22 member 1 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 NCBI chr 6:160,121,808...160,160,590
Ensembl chr 6:160,121,815...160,158,718
JBrowse link
G SLC22A12 solute carrier family 22 member 12 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 NCBI chr11:64,591,219...64,603,250
Ensembl chr11:64,590,641...64,602,353
JBrowse link
G SLC22A4 solute carrier family 22 member 4 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:22865646 NCBI chr 5:132,294,384...132,344,199
Ensembl chr 5:132,294,394...132,344,190
JBrowse link
G SLC22A5 solute carrier family 22 member 5 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein] CTD PMID:22865646 NCBI chr 5:132,369,704...132,395,614
Ensembl chr 5:132,369,752...132,395,614
Ensembl chr 5:132,369,752...132,395,614
JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein] CTD PMID:22865646 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC2A9 solute carrier family 2 member 9 multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein] CTD PMID:22865646 NCBI chr 4:9,771,125...10,040,270
Ensembl chr 4:9,771,153...10,054,936
JBrowse link
G SLC5A1 solute carrier family 5 member 1 affects uptake EXP SLC5A1 protein affects the uptake of polydatin CTD PMID:15686436 NCBI chr22:32,043,050...32,113,029
Ensembl chr22:32,043,261...32,113,029
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases expression
EXP
ISO
polydatin results in increased expression of and results in increased activity of SOD2 protein
polydatin results in increased expression of SOD2 protein
ESR2 gene mutant form inhibits the reaction [polydatin results in increased expression of SOD2 protein]; fulvestrant inhibits the reaction [polydatin results in increased expression of SOD2 protein]
CTD PMID:24361291 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TGFA transforming growth factor alpha multiple interactions EXP [polydatin co-treated with TGFA protein] results in increased expression of CXCL10 mRNA; [polydatin co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; polydatin inhibits the reaction [TGFA protein affects the localization of EGFR protein] CTD PMID:21756928 PMID:21967610 NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO polydatin inhibits the reaction [AGT protein modified form results in increased expression of TGFB1 protein] CTD PMID:25488910 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; polydatin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; polydatin promotes the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]
polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]
polydatin results in decreased expression of TNF mRNA
CTD PMID:21756928 PMID:29130132 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO polydatin inhibits the reaction [Arsenic Trioxide results in increased expression of TP53 mRNA] CTD PMID:29130132 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TSHR thyroid stimulating hormone receptor multiple interactions ISO polydatin inhibits the reaction [TSHR protein results in decreased expression of NFE2L2 protein]; polydatin inhibits the reaction [TSHR protein results in decreased expression of NQO1 protein]; polydatin inhibits the reaction [TSHR protein results in increased expression of KEAP1 protein] CTD PMID:31705858 NCBI chr14:80,954,989...81,146,306
Ensembl chr14:80,954,989...81,146,302
Ensembl chr14:80,954,989...81,146,302
JBrowse link
G TUG1 taurine up-regulated 1 decreases expression EXP polydatin results in decreased expression of TUG1 mRNA CTD PMID:30974157 NCBI chr22:30,969,211...30,979,395
Ensembl chr22:30,969,245...30,979,395
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases hydrolysis EXP UGT1A1 protein results in increased hydrolysis of polydatin metabolite CTD PMID:17009167 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link
G UMOD uromodulin multiple interactions ISO polydatin inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein] CTD PMID:22865646 NCBI chr16:20,333,051...20,356,301
Ensembl chr16:20,333,052...20,356,301
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 24382
    role 24293
      biological role 24260
        biophysical role 13240
          membrane transport modulator 13007
            potassium channel modulator 374
              ezogabine 6
              potassium channel blocker + 325
              potassium channel opener + 25
              trans-piceid 57
paths to the root