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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.1.1.4 (phospholipase A2) inhibitor
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Accession:CHEBI:50469 term browser browse the term
Definition:An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of phospholipase A2 (EC 3.1.1.4).
Synonyms:related_synonym: EC 3.1.1.4 inhibitor;   EC 3.1.1.4 inhibitors;   lecithinase A inhibitor;   lecithinase A inhibitors;   phosphatidase inhibitor;   phosphatidase inhibitors;   phosphatidolipase inhibitor;   phosphatidolipase inhibitors;   phosphatidylcholine 2-acylhydrolase inhibitor;   phosphatidylcholine 2-acylhydrolase inhibitors;   phospholipase A inhibitor;   phospholipase A inhibitors;   phospholipase A2 (EC 3.1.1.4) inhibitors;   phospholipase A2 inhibitor;   phospholipase A2 inhibitors
 alt_id: MESH:D064801
 xref_mesh: MESH:D064801


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EC 3.1.1.4 (phospholipase A2) inhibitor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 decreases secretion EXP Phospholipase A2 Inhibitors results in decreased secretion of IL6 protein CTD PMID:19765281 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions
decreases expression		 ISO Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]
Phospholipase A2 Inhibitors results in decreased expression of MMP1 mRNA		 CTD PMID:19765281 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein]
Phospholipase A2 Inhibitors results in decreased expression of MMP2 mRNA		 CTD PMID:19765281 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
decreases expression		 ISO Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]
Phospholipase A2 Inhibitors results in decreased expression of MMP3 mRNA		 CTD PMID:19765281 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein]
Phospholipase A2 Inhibitors results in decreased expression of MMP9 mRNA		 CTD PMID:19765281 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) multiple interactions
decreases expression		 ISO Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]; Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein]
Phospholipase A2 Inhibitors results in decreased expression of PLA2G2A mRNA		 CTD PMID:19765281 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO Phospholipase A2 Inhibitors results in decreased secretion of TNF protein CTD PMID:19765281 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
AACOCF3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO
EXP		 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL8 mRNA]
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CXCL15 mRNA]		 CTD PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:18938131 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid] CTD PMID:19014389 NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Ins1 insulin I multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [BL 11282 promotes the reaction [Glucose results in increased secretion of INS1 protein]] CTD PMID:17922229 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II increases secretion
multiple interactions		 ISO arachidonyltrifluoromethane results in increased secretion of INS protein
arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein]		 CTD PMID:17192482 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Lep leptin multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LEP mRNA] CTD PMID:19063610 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:15231676 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15231676 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) multiple interactions EXP
ISO		 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PLA2G4A protein]
arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA]		 CTD PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 1:149,705,369...149,837,041
Ensembl chr 1:149,705,369...149,837,041 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PPARG mRNA] CTD PMID:19063610 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of PTGS2 protein]; arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]] CTD PMID:18938131 PMID:19063610 PMID:19162293 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G S100a11 S100 calcium binding protein A11 multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [S100A11 mutant form results in increased susceptibility to Cisplatin]; arachidonyltrifluoromethane inhibits the reaction [S100A11 mutant form results in increased susceptibility to oxaliplatin] CTD PMID:25940438 NCBI chr 3:93,427,803...93,433,595
Ensembl chr 3:93,427,795...93,433,594 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] CTD PMID:19063610 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [TNF protein results in increased expression of SOD2] CTD PMID:11264281 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO arachidonyltrifluoromethane inhibits the reaction [TNF protein results in increased expression of SOD2] CTD PMID:11264281 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP		 arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]
arachidonyltrifluoromethane promotes the reaction [Nifedipine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]]		 CTD PMID:19063610 PMID:19162293 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
berberine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 increases expression EXP berberine increases expression of abca1 protein in mouse liver and human hepatocytes RGD PMID:29505790 RGD:19165131 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A increases expression ISO Berberine results in increased expression of ABCB1A mRNA CTD PMID:20410605 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B increases expression ISO Berberine results in increased expression of ABCB1B mRNA CTD PMID:20410605 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACADM mRNA] CTD PMID:25455889 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Acan aggrecan decreases expression ISO Berberine results in decreased expression of ACAN mRNA CTD PMID:26478571 NCBI chr 7:78,702,974...78,764,847
Ensembl chr 7:78,703,231...78,764,847 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Berberine inhibits the reaction [acetamiprid results in increased activity of ACHE protein]
Berberine results in decreased activity of ACHE protein		 CTD PMID:29170048 PMID:33844597 PMID:37350525 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:25455889 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta decreases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of ACTA2 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of ACTA2 mRNA]		 CTD PMID:17973934 PMID:37839514 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Berberine inhibits the reaction [Clozapine results in increased expression of ADIPOQ mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of AGER mRNA] CTD PMID:35121005 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Ahr aryl-hydrocarbon receptor increases activity ISO Berberine results in increased activity of AHR protein CTD PMID:16046213 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO Berberine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]
Berberine results in decreased phosphorylation of AKT1 protein
Berberine inhibits the reaction [Thioacetamide results in increased phosphorylation of AKT1 protein]
Berberine results in increased phosphorylation of AKT1 protein		 CTD PMID:23954465 PMID:30138605 PMID:33325633 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in decreased expression of AKT2 mRNA] CTD PMID:20462044 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251 		JBrowse link
G Alb albumin multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in decreased expression of ALB protein] CTD PMID:30138605 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Aurkb aurora kinase B decreases expression ISO Berberine results in decreased expression of AURKB mRNA CTD PMID:27311644 NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490 		JBrowse link
G Aurkc aurora kinase C increases expression ISO Berberine results in increased expression of AURKC mRNA CTD PMID:27311644 NCBI chr 7:6,998,346...7,006,090
Ensembl chr 7:6,998,299...7,006,090 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression		 ISO [Berberine co-treated with Thioacetamide] results in increased expression of BAX mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of BAX mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of BAX protein]
Berberine results in increased expression of BAX mRNA; Berberine results in increased expression of BAX protein
[Berberine co-treated with Cisplatin] results in increased expression of BAX protein; [Berberine co-treated with Niacinamide] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased expression of BAX protein]; SRT1720 inhibits the reaction [Berberine results in increased expression of BAX protein]		 CTD PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
multiple interactions		 ISO Berberine results in increased expression of BBC3 mRNA
[Berberine co-treated with Niacinamide] results in increased expression of BBC3 mRNA		 CTD PMID:26712469 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
increases expression
multiple interactions		 ISO Berberine results in decreased expression of BCL2 mRNA; Berberine results in decreased expression of BCL2 protein
Berberine results in increased expression of BCL2 protein
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BCL2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of BCL2 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of BCL2 mRNA]
[Berberine co-treated with Cisplatin] results in decreased expression of BCL2 protein; [Berberine co-treated with Niacinamide] results in decreased expression of BCL2 protein; Berberine inhibits the reaction [Glucose results in decreased expression of BCL2 protein]		 CTD PMID:16505103 PMID:20656010 PMID:23954465 PMID:24751971 PMID:25600690 More... NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO Berberine results in decreased expression of BCL2L1 protein CTD PMID:16505103 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression		 ISO [Berberine co-treated with Niacinamide] results in increased expression of BCL2L11 mRNA
Berberine results in increased expression of BCL2L11 mRNA		 CTD PMID:26712469 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of BECN1 mRNA] CTD PMID:35439518 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression
multiple interactions		 ISO Berberine results in increased expression of BGLAP mRNA; Berberine results in increased expression of BGLAP protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]		 CTD PMID:26478571 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 affects binding ISO Berberine binds to BIRC5 promoter CTD PMID:17968851 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions
increases expression		 ISO [Cisplatin co-treated with Berberine] results in increased expression of BNIP3 protein
Berberine results in increased expression of BNIP3 protein		 CTD PMID:36070022 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like multiple interactions
increases expression		 ISO [Cisplatin co-treated with Berberine] results in increased expression of BNIP3L protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine results in increased expression of BNIP3L protein		 CTD PMID:36070022 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
increases expression		 ISO
EXP		 [Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of CASP3 protein]; Berberine results in increased cleavage of and results in increased activity of CASP3 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]
Berberine increases activity of CASP3 protein in colon epithelial cells
Berberine results in increased cleavage of CASP3 protein
[Berberine co-treated with Thioacetamide] results in increased expression of CASP3 mRNA; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of CASP3 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased activity of CASP3 protein]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of CASP3 mRNA]
Berberine results in increased activity of CASP3 protein
Berberine results in increased expression of CASP3 mRNA		 CTD
RGD		 PMID:16505103 PMID:20656010 PMID:25600690 PMID:26712469 PMID:30138605 More... RGD:152995489 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases activity ISO Berberine results in increased activity of CASP8 protein CTD PMID:20656010 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO
EXP		 Berberine results in increased cleavage of CASP9 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of CASP9 protein]
[Berberine co-treated with Thioacetamide] results in increased expression of CASP9 mRNA
[Berberine co-treated with Niacinamide] results in increased cleavage of CASP9 protein		 CTD PMID:16505103 PMID:26712469 PMID:30138605 PMID:37839514 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Berberine inhibits the reaction [acetamiprid results in decreased activity of CAT protein]; Berberine inhibits the reaction [Bortezomib results in decreased expression of CAT protein]; Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Berberine inhibits the reaction [Thioacetamide results in decreased activity of CAT protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of CAT protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of CAT protein]		 CTD PMID:20828602 PMID:24751971 PMID:25600690 PMID:30138605 PMID:33460233 More... NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of CCL2 protein]		 CTD PMID:16391493 PMID:35691465 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of CCND1 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]		 CTD PMID:16505103 PMID:33325633 PMID:36822301 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Berberine results in decreased expression of CCND2 protein CTD PMID:16505103 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Berberine results in decreased expression of CCNE1 protein CTD PMID:16505103 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr15:98,436,570...98,468,340
Ensembl chr15:98,436,570...98,468,804 		JBrowse link
G Cd36 CD36 molecule multiple interactions
increases expression		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of CD36 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased expression of CD36 protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of CD36 mRNA]; Berberine results in increased expression of and affects the localization of CD36 protein; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]
Berberine results in increased expression of CD36 mRNA; Berberine results in increased expression of CD36 protein		 CTD PMID:28038998 PMID:29408570 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Berberine inhibits the reaction [Particulate Matter results in decreased expression of CDH1 mRNA] CTD PMID:37839514 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Berberine results in decreased expression of CDH2 mRNA CTD PMID:26478571 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Berberine results in decreased expression of CDK2 protein CTD PMID:16505103 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of CDK4 protein
Berberine inhibits the reaction [CDK4 mRNA binds to CCND1 mRNA]		 CTD PMID:16505103 PMID:36822301 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdk6 cyclin dependent kinase 6 decreases expression ISO Berberine results in decreased expression of CDK6 protein CTD PMID:16505103 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Cdk9 cyclin dependent kinase 9 multiple interactions ISO Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 2:32,595,794...32,608,098
Ensembl chr 2:32,595,796...32,603,088 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Berberine results in increased expression of CDKN1A protein CTD PMID:16505103 PMID:23747414 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Berberine results in increased expression of CDKN1B protein CTD PMID:16505103 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdkn1c cyclin dependent kinase inhibitor 1C increases expression ISO Berberine results in increased expression of CDKN1C mRNA CTD PMID:26478571 NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of CEBPA protein]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Berberine results in decreased expression of CEBPA mRNA; Berberine results in decreased expression of CEBPA protein		 CTD PMID:20564506 PMID:26478571 PMID:37511356 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta affects phosphorylation
increases expression
multiple interactions		 EXP
ISO		 Berberine affects the phosphorylation of CEBPB protein
Berberine results in increased expression of CEBPB mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Berberine results in increased phosphorylation of CEBPB protein]; CEBPB protein promotes the reaction [Berberine results in increased expression of CD36 mRNA]		 CTD PMID:28038998 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Berberine results in increased expression of CHEK1 protein modified form CTD PMID:23747414 NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO Berberine results in increased expression of CHEK2 protein modified form CTD PMID:23747414 NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011 		JBrowse link
G Col10a1 collagen, type X, alpha 1 increases expression ISO Berberine results in increased expression of COL10A1 mRNA CTD PMID:26478571 NCBI chr10:34,265,977...34,273,081
Ensembl chr10:34,265,977...34,273,081 		JBrowse link
G Col1a1 collagen, type I, alpha 1 increases expression
multiple interactions		 ISO
EXP		 Berberine results in increased expression of COL1A1 mRNA
Berberine inhibits the reaction [Particulate Matter results in increased expression of COL1A1 mRNA]		 CTD PMID:26478571 PMID:37839514 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col2a1 collagen, type II, alpha 1 decreases expression ISO Berberine results in decreased expression of COL2A1 mRNA CTD PMID:26478571 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions EXP Berberine inhibits the reaction [Particulate Matter results in increased expression of COL3A1 mRNA] CTD PMID:37839514 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4I1 multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of COX4I1 mRNA] CTD PMID:37350525 NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA] CTD PMID:25455889 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in decreased expression of CREB1 protein] CTD PMID:35121005 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crebbp CREB binding protein increases expression ISO Berberine results in increased expression of CREBBP mRNA CTD PMID:27311644 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Ctnnb1 catenin beta 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of CTNNB1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of BGLAP protein]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]		 CTD PMID:26478571 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsd cathepsin D decreases cleavage
multiple interactions		 ISO Berberine results in decreased cleavage of CTSD protein
GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSD protein]		 CTD PMID:36070022 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctsl cathepsin L decreases cleavage
multiple interactions		 ISO Berberine results in decreased cleavage of CTSL protein
Acetylcysteine inhibits the reaction [Berberine results in decreased cleavage of CTSL protein]; GSK2795039 affects the reaction [Berberine results in decreased cleavage of CTSL protein]		 CTD PMID:36070022 NCBI chr13:64,509,704...64,518,586
Ensembl chr13:64,507,151...64,518,704 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of CXCL8 protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein] CTD PMID:16391493 PMID:28916288 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein] CTD PMID:36070022 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO Berberine affects the localization of CYCS protein
[Berberine co-treated with Cisplatin] results in increased expression of CYCS protein		 CTD PMID:16505103 PMID:36070022 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP17A1 mRNA] CTD PMID:20462044 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased activity of CYP1A1 protein
Berberine results in increased expression of CYP1A1 mRNA
Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]		 CTD PMID:16046213 PMID:22342832 PMID:24583342 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA] CTD PMID:22342832 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA]
Berberine results in increased expression of CYP2B10 mRNA		 CTD PMID:22342832 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 multiple interactions
increases expression		 EXP Berberine promotes the reaction [Phenobarbital results in increased expression of CYP2B9 mRNA]; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]
Berberine results in increased expression of CYP2B9 mRNA		 CTD PMID:22342832 NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions		 EXP Berberine results in decreased expression of CYP2E1 mRNA
Berberine inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]; Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]		 CTD PMID:22342832 PMID:25455889 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
decreases expression		 EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of CYP3A11 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP3A11 mRNA]
Berberine results in decreased expression of CYP3A11 mRNA		 CTD PMID:22342832 NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774 		JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 multiple interactions
decreases expression		 EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A10 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A10 mRNA]
Berberine results in decreased expression of CYP4A10 mRNA		 CTD PMID:22342832 NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846 		JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
decreases expression		 EXP Berberine inhibits the reaction [Clofibrate results in increased expression of CYP4A14 mRNA]; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A14 mRNA]
Berberine results in decreased expression of CYP4A14 mRNA		 CTD PMID:22342832 NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO DKK1 protein inhibits the reaction [Berberine results in increased expression of BGLAP protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of CTNNB1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein] CTD PMID:26478571 NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO Berberine results in decreased expression of DNMT1 mRNA CTD PMID:27311644 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression ISO Berberine results in decreased expression of DNMT3B mRNA CTD PMID:27311644 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650 		JBrowse link
G Dzip3 DAZ interacting protein 3, zinc finger increases expression ISO Berberine results in increased expression of DZIP3 mRNA CTD PMID:27311644 NCBI chr16:48,744,591...48,814,505
Ensembl chr16:48,744,595...48,814,528 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein] CTD PMID:33325633 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Berberine results in decreased expression of EGFR protein CTD PMID:33325633 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Berberine results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein CTD PMID:23363784 NCBI chr 8:27,750,355...27,765,684
Ensembl chr 8:27,750,357...27,766,702 		JBrowse link
G Ep300 E1A binding protein p300 increases expression ISO Berberine results in increased expression of EP300 mRNA CTD PMID:27311644 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Berberine results in decreased expression of ERBB2 protein]; Berberine results in decreased expression of and results in increased ubiquitination of ERBB2 protein CTD PMID:33325633 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Berberine inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Berberine inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,888,345...6,899,182
Ensembl chr19:6,888,345...6,899,208 		JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte decreases expression
increases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of FABP4 mRNA
Berberine results in increased expression of FABP4 mRNA
15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of FABP4 mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of FABP4 mRNA]		 CTD PMID:26478571 PMID:29408570 NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 EXP
ISO		 [Clozapine co-treated with Berberine] results in decreased expression of FAS mRNA; Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA]
Berberine results in increased expression of FAS mRNA; Berberine results in increased expression of FAS protein		 CTD PMID:20564506 PMID:20656010 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fasl Fas ligand increases expression ISO Berberine results in increased expression of FASLG mRNA; Berberine results in increased expression of FASLG protein CTD PMID:20656010 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO
EXP		 Berberine inhibits the reaction [Thioacetamide results in increased expression of FN1 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of FN1 mRNA]		 CTD PMID:30138605 PMID:37839514 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO1 protein; Berberine results in increased expression of and results in increased acetylation of FOXO1 protein CTD PMID:26712469 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of FOXO3 protein; Berberine results in increased expression of and results in increased acetylation of FOXO3 protein CTD PMID:26712469 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fundc1 FUN14 domain containing 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of FUNDC1 protein
[Cisplatin co-treated with Berberine] results in increased expression of FUNDC1 protein; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]		 CTD PMID:36070022 NCBI chr  X:17,386,206...17,438,600
Ensembl chr  X:17,422,803...17,438,564 		JBrowse link
G Gata2 GATA binding protein 2 increases expression EXP Berberine results in increased expression of GATA2 mRNA CTD PMID:37511356 NCBI chr 6:88,170,873...88,184,014
Ensembl chr 6:88,170,873...88,184,014 		JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Berberine results in increased expression of GATA3 mRNA CTD PMID:37511356 NCBI chr 2:9,861,889...9,894,845
Ensembl chr 2:9,861,889...9,894,845 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GCLC mRNA] CTD PMID:35121005 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GCLM mRNA] CTD PMID:35121005 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Berberine results in decreased expression of GDF5 mRNA CTD PMID:26478571 NCBI chr 2:155,782,943...155,787,204
Ensembl chr 2:155,782,943...155,787,287 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of GFAP mRNA] CTD PMID:35121005 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions EXP
ISO		 Berberine inhibits the reaction [Ethanol results in increased activity of GPT protein]
Berberine inhibits the reaction [Mercuric Chloride results in increased activity of GPT protein]; Berberine inhibits the reaction [Thioacetamide results in increased activity of GPT protein]		 CTD PMID:24751971 PMID:25455889 PMID:30138605 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of GPX1 mRNA] CTD PMID:24751971 PMID:33460233 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation		 EXP
ISO		 Berberine inhibits the reaction [Dexamethasone results in decreased expression of GSK3B mRNA]
Berberine results in increased phosphorylation of GSK3B protein
Berberine inhibits the reaction [Glucose results in decreased phosphorylation of GSK3B protein]		 CTD PMID:20462044 PMID:23954465 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]; Berberine inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein] CTD PMID:24751971 PMID:25600690 PMID:33460233 PMID:35439518 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G H2ac10 H2A clustered histone 10 decreases expression ISO Berberine results in decreased expression of H2AC14 mRNA CTD PMID:27311644 NCBI chr13:23,718,045...23,718,548
Ensembl chr13:23,718,076...23,718,474 		JBrowse link
G H2ac12 H2A clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2AC12 mRNA CTD PMID:27311644 NCBI chr13:22,219,292...22,219,813
Ensembl chr13:22,219,334...22,219,738 		JBrowse link
G H2ac13 H2A clustered histone 13 decreases expression ISO Berberine results in decreased expression of H2AC8 mRNA CTD PMID:27311644 NCBI chr13:21,900,582...21,901,029
Ensembl chr13:21,900,592...21,900,984 		JBrowse link
G H2ac18 H2A clustered histone 18 decreases expression ISO Berberine results in decreased expression of H2AC18 mRNA CTD PMID:27311644 NCBI chr 3:96,152,853...96,153,439
Ensembl chr 3:96,152,813...96,153,398 		JBrowse link
G H2ac22 H2A clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2AC11 mRNA CTD PMID:27311644 NCBI chr13:21,970,944...21,971,418
Ensembl chr13:21,970,996...21,971,388 		JBrowse link
G H2ac25 H2A clustered histone 25 decreases expression ISO Berberine results in decreased expression of H2AC25 mRNA CTD PMID:27311644 NCBI chr11:58,845,511...58,846,018
Ensembl chr11:58,845,511...58,847,656 		JBrowse link
G H2ac4 H2A clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2AC4 mRNA CTD PMID:27311644 NCBI chr13:23,935,061...23,935,577
Ensembl chr13:23,935,109...23,935,581 		JBrowse link
G H2ac6 H2A clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2AC15 mRNA CTD PMID:27311644 NCBI chr13:23,867,456...23,867,942
Ensembl chr13:23,865,450...23,867,931 		JBrowse link
G H2ax H2A.X variant histone increases expression
decreases expression
multiple interactions		 ISO Berberine results in increased expression of H2AX protein modified form
Berberine results in decreased expression of H2AX mRNA; Berberine results in decreased expression of H2AX protein
TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]		 CTD PMID:23363784 PMID:23747414 PMID:27311644 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Berberine results in decreased expression of H2BC12 mRNA CTD PMID:27311644 NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515 		JBrowse link
G H2bc14 H2B clustered histone 14 decreases expression ISO Berberine results in decreased expression of H2BC5 mRNA CTD PMID:27311644 NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737 		JBrowse link
G H2bc15 H2B clustered histone 15 decreases expression ISO Berberine results in decreased expression of H2BC15 mRNA CTD PMID:27311644 NCBI chr13:21,938,246...21,938,723
Ensembl chr13:21,938,293...21,938,673 		JBrowse link
G H2bc21 H2B clustered histone 21 decreases expression ISO Berberine results in decreased expression of H2BC11 mRNA CTD PMID:27311644 NCBI chr 3:96,128,435...96,131,057
Ensembl chr 3:96,128,435...96,131,054 		JBrowse link
G H2bc22 H2B clustered histone 22 decreases expression ISO Berberine results in decreased expression of H2BC17 mRNA CTD PMID:27311644 NCBI chr13:21,971,652...21,985,731
Ensembl chr13:21,971,631...21,973,383 		JBrowse link
G H2bc4 H2B clustered histone 4 decreases expression ISO Berberine results in decreased expression of H2BC4 mRNA CTD PMID:27311644 NCBI chr13:23,868,182...23,876,805
Ensembl chr13:23,868,182...23,876,891 		JBrowse link
G H2bc6 H2B clustered histone 6 decreases expression ISO Berberine results in decreased expression of H2BC6 mRNA CTD PMID:27311644 NCBI chr13:23,767,653...23,805,091
Ensembl chr13:23,767,653...23,805,107 		JBrowse link
G H2bc7 H2B clustered histone 7 decreases expression ISO Berberine results in decreased expression of H2BC13 mRNA CTD PMID:27311644 NCBI chr13:23,757,934...23,758,381
Ensembl chr13:23,757,910...23,758,370 		JBrowse link
G H2bc8 H2B clustered histone 8 decreases expression ISO Berberine results in decreased expression of H2BC8 mRNA CTD PMID:27311644 NCBI chr13:23,755,574...23,756,037
Ensembl chr13:23,755,570...23,756,187 		JBrowse link
G H2bc9 H2B clustered histone 9 decreases expression ISO Berberine results in decreased expression of H2BC9 mRNA CTD PMID:27311644 NCBI chr13:23,727,093...23,727,614
Ensembl chr13:23,725,884...23,727,562 		JBrowse link
G H2bw2 H2B.W histone 2 decreases expression ISO Berberine results in decreased expression of H2BW2 mRNA CTD PMID:27311644 NCBI chr  X:135,828,074...135,829,122
Ensembl chr  X:135,828,074...135,829,125 		JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Berberine results in decreased expression of H3C1 mRNA CTD PMID:27311644 NCBI chr13:23,945,868...23,946,369
Ensembl chr13:23,945,836...23,946,369 		JBrowse link
G H3c11 H3 clustered histone 11 decreases expression ISO Berberine results in decreased expression of H3C7 mRNA CTD PMID:27311644 NCBI chr13:21,967,085...21,967,567
Ensembl chr13:21,967,130...21,967,540 		JBrowse link
G H3c8 H3 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H3C12 mRNA CTD PMID:27311644 NCBI chr13:23,719,588...23,720,079
Ensembl chr13:23,719,592...23,720,121 		JBrowse link
G H3f3a H3.3 histone A decreases expression ISO Berberine results in decreased expression of H3-3A mRNA CTD PMID:27311644 NCBI chr 1:180,630,125...180,641,127
Ensembl chr 1:180,628,397...180,641,508 		JBrowse link
G H3f4 H3.4 histone, cluster member decreases expression ISO Berberine results in decreased expression of H3-4 mRNA CTD PMID:27311644 NCBI chr11:58,852,537...58,853,099
Ensembl chr11:58,852,599...58,853,364 		JBrowse link
G H4c12 H4 clustered histone 12 decreases expression ISO Berberine results in decreased expression of H4C8 mRNA CTD PMID:27311644 NCBI chr13:21,934,315...21,934,723
Ensembl chr13:21,934,364...21,934,675 		JBrowse link
G H4c14 H4 clustered histone 14 decreases expression ISO Berberine results in decreased expression of H4C3 mRNA CTD PMID:27311644 NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627 		JBrowse link
G H4c2 H4 clustered histone 2 decreases expression ISO Berberine results in decreased expression of H4C14 mRNA CTD PMID:27311644 NCBI chr13:23,940,920...23,941,369
Ensembl chr13:23,940,996...23,941,392 		JBrowse link
G H4c8 H4 clustered histone 8 decreases expression ISO Berberine results in decreased expression of H4C9 mRNA CTD PMID:27311644 NCBI chr13:23,715,214...23,715,648
Ensembl chr13:23,715,220...23,715,689 		JBrowse link
G Hat1 histone aminotransferase 1 increases expression ISO Berberine results in increased expression of HAT1 mRNA CTD PMID:27311644 NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966 		JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO Berberine results in decreased expression of HDAC2 mRNA CTD PMID:27311644 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hdac5 histone deacetylase 5 increases expression ISO Berberine results in increased expression of HDAC5 mRNA CTD PMID:27311644 NCBI chr11:102,085,244...102,120,968
Ensembl chr11:102,085,258...102,120,992 		JBrowse link
G Hdac8 histone deacetylase 8 decreases expression ISO Berberine results in decreased expression of HDAC8 mRNA CTD PMID:27311644 NCBI chr  X:101,328,244...101,549,005
Ensembl chr  X:101,328,245...101,548,965 		JBrowse link
G Hdac9 histone deacetylase 9 decreases expression
increases expression		 ISO Berberine results in decreased expression of HDAC9 mRNA
Berberine results in increased expression of HDAC9 mRNA		 CTD PMID:27311644 NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions
increases expression		 ISO
EXP		 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF mRNA]; 15-deoxyprostaglandin J2 promotes the reaction [Berberine results in increased expression of HGF protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Berberine results in increased expression of HGF protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF mRNA]; Berberine promotes the reaction [15-deoxyprostaglandin J2 results in increased expression of HGF protein]; Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein]; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
Berberine inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]
Berberine results in increased expression of HGF mRNA; Berberine results in increased expression of HGF protein		 CTD PMID:29408570 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Berberine results in increased expression of HMOX1 protein
Berberine results in increased expression of HMOX1 mRNA; Berberine results in increased expression of HMOX1 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of HMOX1 protein]
Berberine inhibits the reaction [Bortezomib results in increased expression of HMOX1 mRNA]
Berberine promotes the reaction [Glucose results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]		 CTD PMID:23954465 PMID:35121005 PMID:37511356 PMID:37839514 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnf4a hepatic nuclear factor 4, alpha multiple interactions ISO
EXP		 Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A mRNA]; Berberine inhibits the reaction [Fructose results in decreased expression of HNF4A protein]
Berberine inhibits the reaction [Ethanol results in decreased expression of HNF4 protein]		 CTD PMID:18563319 PMID:25455889 NCBI chr 2:163,348,731...163,414,827
Ensembl chr 2:163,348,728...163,414,830 		JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha decreases expression ISO Berberine results in decreased expression of IDH3A mRNA CTD PMID:30818834 NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Berberine inhibits the reaction [Thioacetamide results in increased expression of IFNG mRNA] CTD PMID:30138605 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Igf1r insulin-like growth factor I receptor multiple interactions
increases expression		 ISO Berberine inhibits the reaction [Glucose results in decreased expression of IGF1R protein]
Berberine results in increased expression of IGF1R protein		 CTD PMID:23954465 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 decreases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of IGF2BP3 protein
Berberine inhibits the reaction [[Dextran Sulfate co-treated with azomethane] results in increased expression of IGF2BP3 protein]
[Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein; Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein]; Cycloheximide promotes the reaction [Berberine results in decreased expression of IGF2BP3 protein]		 CTD PMID:36822301 NCBI chr 6:49,062,152...49,200,225
Ensembl chr 6:49,062,157...49,191,891 		JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression		 EXP
ISO		 Berberine affects the reaction [Lipopolysaccharides affects the expression of IL10 mRNA]
[Berberine co-treated with Thioacetamide] results in increased expression of IL10 mRNA
Berberine results in increased expression of IL10 mRNA		 CTD PMID:21867779 PMID:30138605 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Berberine inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL1B mRNA]		 CTD PMID:16391493 PMID:29170048 PMID:30138605 PMID:35121005 PMID:35691465 More... NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 increases expression EXP Berberine results in increased expression of IL2 mRNA CTD PMID:21867779 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il23a interleukin 23, alpha subunit p19 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein] CTD PMID:30240693 NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA]
Berberine results in increased expression of IL4 mRNA		 CTD PMID:21867779 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of IL6 protein]; Berberine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]; Berberine inhibits the reaction [Mustard Gas results in increased secretion of IL6 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]		 CTD PMID:28916288 PMID:29170048 PMID:30138605 PMID:30240693 PMID:34427876 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga1 integrin alpha 1 increases expression ISO Berberine results in increased expression of ITGA1 mRNA CTD PMID:26478571 NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500 		JBrowse link
G Itgb4 integrin beta 4 increases expression ISO berberine increases expression of ITGB4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr11:115,865,556...115,899,238
Ensembl chr11:115,865,535...115,899,238 		JBrowse link
G Jun jun proto-oncogene affects localization
multiple interactions		 ISO Berberine affects the localization of JUN protein
arsenic trioxide promotes the reaction [Berberine affects the localization of JUN protein]		 CTD PMID:18294404 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity
multiple interactions		 ISO Berberine results in decreased activity of KCNH2 protein
Berberine promotes the reaction [Atorvastatin results in decreased activity of KCNH2 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of KCNH2 protein]		 CTD PMID:30086269 NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602 		JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A increases expression ISO Berberine results in increased expression of KDM1A mRNA CTD PMID:27311644 NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034 		JBrowse link
G Kdm4a lysine (K)-specific demethylase 4A increases expression ISO Berberine results in increased expression of KDM4A mRNA CTD PMID:27311644 NCBI chr 4:117,994,154...118,037,216
Ensembl chr 4:117,994,154...118,037,240 		JBrowse link
G Kdm5b lysine demethylase 5B increases expression ISO Berberine results in increased expression of KDM5B mRNA CTD PMID:27311644 NCBI chr 1:134,487,916...134,560,621
Ensembl chr 1:134,487,909...134,563,023 		JBrowse link
G Kdm6a lysine (K)-specific demethylase 6A increases expression ISO Berberine results in increased expression of KDM6A mRNA CTD PMID:27311644 NCBI chr  X:18,027,101...18,147,061
Ensembl chr  X:18,028,814...18,146,175 		JBrowse link
G Kdm6b KDM1 lysine (K)-specific demethylase 6B increases expression ISO Berberine results in increased expression of KDM6B mRNA CTD PMID:27311644 NCBI chr11:69,289,334...69,311,188
Ensembl chr11:69,289,334...69,304,501 		JBrowse link
G Kmt5a lysine methyltransferase 5A increases expression ISO Berberine results in increased expression of KMT5A mRNA CTD PMID:27311644 NCBI chr 5:124,577,980...124,600,371
Ensembl chr 5:124,577,993...124,600,371 		JBrowse link
G Kpna4 karyopherin subunit alpha 4 multiple interactions ISO Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]] CTD PMID:34427876 NCBI chr 3:68,979,554...69,034,425
Ensembl chr 3:68,974,482...69,034,446 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of LDLR mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA]
Berberine results in increased expression of LDLR mRNA
Berberine promotes the reaction [Simvastatin results in increased expression of LDLR mRNA]; Simvastatin promotes the reaction [Berberine results in increased expression of LDLR mRNA]		 CTD PMID:18640378 PMID:20564506 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases localization		 ISO [Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein; Berberine results in increased expression of and results in increased lipidation of MAP1LC3B protein; BNIP3L protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]; FUNDC1 protein affects the reaction [[Berberine co-treated with Cisplatin] results in increased lipidation of MAP1LC3B protein]
Berberine inhibits the reaction [Chlorpyrifos results in decreased expression of MAP1LC3B mRNA]
Berberine results in increased localization of MAP1LC3B protein		 CTD PMID:35439518 PMID:36070022 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein] CTD PMID:30240693 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO Berberine results in decreased phosphorylation of MAPK1 protein CTD PMID:18294404 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO
EXP		 Berberine results in decreased phosphorylation of MAPK3 protein
Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]		 CTD PMID:18294404 PMID:20462044 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased phosphorylation of MAPK8 protein] CTD PMID:36070022 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] CTD PMID:29170048 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions EXP Berberine inhibits the reaction [Dexamethasone results in increased expression of MCM2 mRNA] CTD PMID:20462044 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762 		JBrowse link
G Mir142 microRNA 142 multiple interactions ISO Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MIR142 mRNA]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of KPNA4 protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]] CTD PMID:34427876 NCBI chr11:87,647,690...87,647,753
Ensembl chr11:87,647,690...87,647,753 		JBrowse link
G Mir19a microRNA 19a decreases expression ISO Berberine results in decreased expression of MIR19A mRNA CTD PMID:29687521 NCBI chr14:115,281,432...115,281,513
Ensembl chr14:115,281,432...115,281,513 		JBrowse link
G Mir21a microRNA 21a decreases expression ISO berberine decreases expression of MIR21 RNA in colon epithelial cell RGD PMID:29564000 RGD:152995489 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir92-1 microRNA 92-1 decreases expression ISO Berberine results in decreased expression of MIR92A1 mRNA CTD PMID:29687521 NCBI chr14:115,281,859...115,281,938
Ensembl chr14:115,281,859...115,281,938 		JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Berberine results in increased expression of MMP13 mRNA CTD PMID:26478571 NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) multiple interactions
decreases expression		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein] CTD PMID:18294404 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
decreases expression		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; Arsenic Trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; Berberine promotes the reaction [Arsenic Trioxide results in decreased activity of MMP2 protein]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]
Berberine results in decreased expression of MMP2 protein
arsenic trioxide promotes the reaction [Berberine results in decreased activity of MMP2 protein]; arsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP2 protein]; Berberine promotes the reaction [arsenic trioxide results in decreased activity of MMP2 protein]		 CTD PMID:18294404 PMID:33325633 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
multiple interactions		 ISO Berberine results in decreased activity of MMP9 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]		 CTD PMID:33325633 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of MPO protein] CTD PMID:21963898 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of COX1 mRNA] CTD PMID:37350525 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872 		JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of ND1 mRNA] CTD PMID:37350525 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707 		JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial multiple interactions ISO Berberine inhibits the reaction [acetamiprid results in decreased expression of ND2 mRNA] CTD PMID:37350525 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR mRNA]; Berberine inhibits the reaction [Chlorpyrifos results in increased expression of MTOR protein] CTD PMID:35439518 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of MTTP protein] CTD PMID:25455889 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Myc myelocytomatosis oncogene multiple interactions
affects localization		 ISO arsenic trioxide promotes the reaction [Berberine affects the localization of MYC protein] CTD PMID:18294404 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase multiple interactions
decreases expression		 ISO [Berberine co-treated with Niacinamide] results in decreased expression of NAMPT protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of NAMPT protein] CTD PMID:26712469 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF1 protein] CTD PMID:36070022 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to NCF2 protein] CTD PMID:36070022 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions
increases activity		 ISO
EXP		 Berberine results in increased expression of NFE2L2 protein
Berberine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]
Berberine results in increased activity of NFE2L2 protein
Berberine inhibits the reaction [Bortezomib results in increased expression of NFE2L2 mRNA]; Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]
NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]		 CTD PMID:23523906 PMID:23954465 PMID:30818834 PMID:35121005 PMID:37839514 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of NFKB1 mRNA] CTD PMID:35121005 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP
ISO		 Berberine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of NFKBIA protein]]		 CTD PMID:21963898 PMID:34427876 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Berberine inhibits the reaction [Glucose results in decreased expression of NGF protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] CTD PMID:23954465 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Berberine inhibits the reaction [Bortezomib results in increased expression of NLRP3 mRNA] CTD PMID:35121005 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP
ISO		 Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
Berberine inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]		 CTD PMID:21095217 PMID:23523906 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions ISO Berberine reverses reaction [Carbontetrachloride decreases Nqo1 mRNA in liver]
Berberine inhibits the reaction [Bortezomib results in increased expression of NQO1 mRNA]		 CTD
RGD		 PMID:35121005 PMID:31432116 RGD:25823187 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases localization ISO Berberine increases localization of NR1H3 protein in macrophage nucleus RGD PMID:20506155 RGD:401827279 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Berberine results in increased activity of NR1I2 protein
[Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:21524698 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Berberine results in increased activity of NR1I3 protein CTD PMID:30818834 NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 decreases expression ISO Berberine results in decreased expression of NSD2 mRNA CTD PMID:27311644 NCBI chr 5:33,974,286...34,055,310
Ensembl chr 5:33,978,069...34,055,319 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 multiple interactions
decreases expression		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased expression of ODC1 protein] CTD PMID:18294404 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Omd osteomodulin increases expression ISO Berberine results in increased expression of OMD mRNA CTD PMID:26478571 NCBI chr13:49,735,938...49,746,088
Ensembl chr13:49,735,938...49,746,298 		JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 multiple interactions ISO Berberine affects the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased activity of P2RX7 protein] CTD PMID:21320518 NCBI chr 5:122,781,990...122,830,399
Ensembl chr 5:122,781,974...122,829,495 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions		 ISO Berberine results in increased cleavage of PARP1 protein
[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein; [Berberine co-treated with Niacinamide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Berberine co-treated with Cisplatin] results in increased cleavage of PARP1 protein]		 CTD PMID:16505103 PMID:26712469 PMID:36070022 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Berberine increases expression of PDCD4 protein in colon epithelial cells RGD PMID:29564000 RGD:152995489 NCBI chr19:53,880,662...53,926,024
Ensembl chr19:53,880,662...53,918,291 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression EXP Berberine results in increased expression of PDK4 mRNA CTD PMID:37511356 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:25455889 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta increases activity
increases expression		 EXP Berberine results in increased activity of PPARD protein
Berberine results in increased expression of PPARD mRNA; Berberine results in increased expression of PPARD protein		 CTD PMID:37511356 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
increases response to substance
increases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of PPARG protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
Berberine results in decreased expression of PPARG mRNA; Berberine results in decreased expression of PPARG protein
15-deoxyprostaglandin J2 promotes the reaction [Berberine affects the localization of and results in increased activity of PPARG protein]; Berberine inhibits the reaction [Bleomycin binds to PPARG protein]; Berberine promotes the reaction [15-deoxyprostaglandin J2 affects the localization of and results in increased activity of PPARG protein]; Berberine results in increased activity of and affects the localization of PPARG protein; PPARG mRNA promotes the reaction [Berberine results in increased expression of HGF protein]
PPARG mRNA results in increased susceptibility to Berberine
Berberine results in increased expression of PPARG mRNA		 CTD PMID:20564506 PMID:26478571 PMID:29408570 PMID:37511356 PMID:37839514 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions EXP Berberine inhibits the reaction [Ethanol results in decreased expression of PPARGC1A mRNA] CTD PMID:25455889 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prg4 proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) decreases expression ISO Berberine results in decreased expression of PRG4 mRNA CTD PMID:26478571 NCBI chr 1:150,325,163...150,341,916
Ensembl chr 1:150,325,163...150,341,916 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases phosphorylation EXP Berberine results in increased phosphorylation of PRKAA1 protein CTD PMID:28298333 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCA protein]; Berberine results in decreased activity of and affects the localization of PRKCA protein CTD PMID:18294404 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions
decreases activity		 ISO arsenic trioxide promotes the reaction [Berberine results in decreased activity of PRKCE protein]; Berberine results in decreased activity of and affects the localization of PRKCE protein CTD PMID:18294404 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases expression ISO Berberine results in decreased expression of PRMT1 mRNA CTD PMID:27311644 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992 		JBrowse link
G Prmt2 protein arginine N-methyltransferase 2 increases expression ISO Berberine results in increased expression of PRMT2 mRNA CTD PMID:27311644 NCBI chr10:76,043,060...76,073,699
Ensembl chr10:76,043,056...76,073,699 		JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 increases expression ISO Berberine results in increased expression of PRMT5 mRNA CTD PMID:27311644 NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982 		JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 increases expression ISO Berberine results in increased expression of PRMT6 mRNA CTD PMID:27311644 NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314 		JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 increases expression ISO Berberine results in increased expression of PRMT7 mRNA CTD PMID:27311644 NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426 		JBrowse link
G Prmt8 protein arginine N-methyltransferase 8 increases expression ISO Berberine results in increased expression of PRMT8 mRNA CTD PMID:27311644 NCBI chr 6:127,665,972...127,746,430
Ensembl chr 6:127,665,974...127,746,435 		JBrowse link
G Pten phosphatase and tensin homolog increases expression
multiple interactions		 EXP Berberine results in increased expression of PTEN protein
((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide) inhibits the reaction [Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN mRNA]; Berberine inhibits the reaction [Bleomycin results in decreased expression of PTEN protein]		 CTD PMID:29408570 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein] CTD PMID:21095217 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rac2 Rac family small GTPase 2 multiple interactions ISO Berberine promotes the reaction [CYBB protein binds to NCF1 protein binds to NCF2 protein binds to RAC2 protein]; Berberine promotes the reaction [CYBB protein binds to RAC2 protein]; Berberine results in increased expression of and results in increased activity of RAC2 protein CTD PMID:36070022 NCBI chr15:78,443,369...78,456,983
Ensembl chr15:78,443,367...78,456,983 		JBrowse link
G Rbp4 retinol binding protein 4, plasma multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr19:38,105,068...38,113,769
Ensembl chr19:38,105,077...38,113,729 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Berberine inhibits the reaction [Bleomycin affects the localization of and results in increased expression of RELA protein]
Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of RELA protein]]		 CTD PMID:23523906 PMID:34427876 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rln1 relaxin 1 affects binding
increases expression
multiple interactions		 ISO Berberine binds to RLN1 promoter
Berberine results in increased expression of RLN1 mRNA
[Berberine binds to RLN1 promoter] which results in increased expression of RLN1 mRNA		 CTD PMID:22363579 NCBI chr19:29,309,155...29,312,070
Ensembl chr19:29,308,570...29,312,070 		JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO Berberine results in decreased phosphorylation of RPS6 protein CTD PMID:23363784 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions
increases expression		 ISO CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [Berberine results in increased expression of RUNX2 mRNA] CTD PMID:26478571 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684 		JBrowse link
G Setd1b SET domain containing 1B increases expression ISO Berberine results in increased expression of SETD1B mRNA CTD PMID:27311644 NCBI chr 5:123,280,109...123,306,693
Ensembl chr 5:123,280,256...123,306,692 		JBrowse link
G Setd2 SET domain containing 2 increases expression ISO Berberine results in increased expression of SETD2 mRNA CTD PMID:27311644 NCBI chr 9:110,361,368...110,447,703
Ensembl chr 9:110,361,665...110,447,701 		JBrowse link
G Setd3 SET domain containing 3 increases expression ISO Berberine results in increased expression of SETD3 mRNA CTD PMID:27311644 NCBI chr12:108,072,690...108,145,616
Ensembl chr12:108,072,690...108,145,573 		JBrowse link
G Setd5 SET domain containing 5 increases expression ISO Berberine results in increased expression of SETD5 mRNA CTD PMID:27311644 NCBI chr 6:113,054,326...113,130,393
Ensembl chr 6:113,054,326...113,130,396 		JBrowse link
G Setd6 SET domain containing 6 increases expression ISO Berberine results in increased expression of SETD6 mRNA CTD PMID:27311644 NCBI chr 8:96,442,211...96,448,135
Ensembl chr 8:96,442,509...96,445,638 		JBrowse link
G Setd7 SET domain containing (lysine methyltransferase) 7 increases expression ISO Berberine results in increased expression of SETD7 mRNA CTD PMID:27311644 NCBI chr 3:51,422,740...51,468,519
Ensembl chr 3:51,422,740...51,468,300 		JBrowse link
G Setdb1 SET domain, bifurcated 1 increases expression ISO Berberine results in increased expression of SETDB1 mRNA CTD PMID:27311644 NCBI chr 3:95,230,836...95,264,513
Ensembl chr 3:95,230,836...95,264,513 		JBrowse link
G Setdb2 SET domain, bifurcated 2 increases expression ISO Berberine results in increased expression of SETDB2 mRNA CTD PMID:27311644 NCBI chr14:59,639,458...59,678,329
Ensembl chr14:59,639,458...59,678,333 		JBrowse link
G Sirt1 sirtuin 1 decreases expression
multiple interactions		 ISO Berberine results in decreased expression of SIRT1 mRNA; Berberine results in decreased expression of SIRT1 protein
Berberine inhibits the reaction [Bortezomib results in decreased expression of SIRT1 protein]
[Berberine co-treated with Niacinamide] results in decreased expression of SIRT1 protein; SRT1720 inhibits the reaction [Berberine results in decreased expression of SIRT1 protein]		 CTD PMID:26712469 PMID:35121005 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT2 protein CTD PMID:26712469 NCBI chr 7:28,466,192...28,488,086
Ensembl chr 7:28,466,160...28,488,086 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression		 ISO [Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein
Berberine results in increased expression of SIRT3 mRNA
Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 protein		 CTD PMID:26712469 PMID:27311644 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Sis sucrase isomaltase decreases expression
multiple interactions		 ISO Berberine results in decreased expression of SI mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA]		 CTD PMID:20229011 NCBI chr 3:72,795,890...72,875,196
Ensembl chr 3:72,795,890...72,875,196 		JBrowse link
G Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 decreases expression ISO Berberine results in decreased expression of SLC27A5 mRNA CTD PMID:28038998 NCBI chr 7:12,722,273...12,732,119
Ensembl chr 7:12,722,273...12,732,119 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions ISO Berberine inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein] CTD PMID:19080170 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 multiple interactions ISO Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 mRNA]; Berberine affects the reaction [Lipopolysaccharides affects the expression of SLC6A19 protein] CTD PMID:21073932 NCBI chr13:73,827,864...73,848,899
Ensembl chr13:73,827,864...73,852,984 		JBrowse link
G Smyd3 SET and MYND domain containing 3 affects expression ISO Berberine affects the expression of SMYD3 mRNA CTD PMID:27311644 NCBI chr 1:178,779,525...179,345,618
Ensembl chr 1:178,779,525...179,345,606 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 mRNA]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOCS3 protein] CTD PMID:37839514 NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP
ISO		 Berberine inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]; Berberine inhibits the reaction [Particulate Matter results in decreased expression of SOD1 protein]; Berberine inhibits the reaction [Streptozocin affects the expression of SOD1 mRNA]
Berberine inhibits the reaction [Chlorpyrifos results in decreased activity of SOD1 protein]		 CTD PMID:21095217 PMID:22775417 PMID:35439518 PMID:37839514 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP
ISO		 Berberine inhibits the reaction [Streptozocin affects the expression of SOD2 mRNA]
Berberine inhibits the reaction [acetamiprid results in decreased expression of SOD2 mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in decreased expression of SOD2 mRNA]		 CTD PMID:22775417 PMID:24751971 PMID:33460233 PMID:37350525 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 decreases expression ISO Berberine results in decreased expression of SOX9 mRNA CTD PMID:26478571 NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586 		JBrowse link
G Sp7 Sp7 transcription factor 7 increases expression ISO Berberine results in increased expression of SP7 mRNA CTD PMID:26478571 NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617 		JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein increases expression ISO Berberine results in increased expression of SPARC mRNA CTD PMID:26478571 NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression
multiple interactions		 ISO Berberine results in increased expression of SPP1 mRNA; Berberine results in increased expression of SPP1 protein
CTNNB1 mutant form inhibits the reaction [Berberine results in increased expression of SPP1 protein]; DKK1 protein inhibits the reaction [Berberine results in increased expression of SPP1 protein]		 CTD PMID:26478571 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Berberine results in increased expression of SQSTM1 protein CTD PMID:36070022 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
decreases expression		 EXP
ISO		 Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Clozapine results in increased expression of SREBF1 protein]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Berberine results in decreased expression of SREBF1 mRNA		 CTD PMID:20564506 PMID:26478571 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP		 Berberine inhibits the reaction [Bortezomib results in increased expression of STAT3 mRNA]
Berberine inhibits the reaction [Particulate Matter results in increased expression of STAT3 mRNA]		 CTD PMID:35121005 PMID:37839514 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tert telomerase reverse transcriptase decreases activity ISO Berberine results in decreased activity of TERT protein CTD PMID:25265580 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 ISO
EXP		 Berberine results in decreased expression of TGFB1 protein
Berberine inhibits the reaction [Particulate Matter results in increased expression of TGFB1 mRNA]
Berberine inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Berberine inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]		 CTD PMID:17973934 PMID:23523906 PMID:30138605 PMID:37839514 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP
ISO		 Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]
Berberine inhibits the reaction [Bortezomib results in increased expression of TLR4 protein]		 CTD PMID:21963898 PMID:30240693 PMID:35121005 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO
EXP		 Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]; Berberine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Berberine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Berberine inhibits the reaction [TNF protein results in increased secretion of CCL2 protein]; Berberine inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; KPNA4 protein inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; LINC00943 inhibits the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]; MIR142 affects the reaction [Berberine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF protein]]
Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; Berberine inhibits the reaction [Bleomycin results in increased expression of TNF protein]; Berberine inhibits the reaction [Bortezomib results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Mercuric Chloride results in increased expression of TNF protein]
Berberine results in increased secretion of TNF protein
Berberine results in increased expression of TNF mRNA
Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in decreased expression of and results in increased phosphorylation of MAP3K5 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL23A mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of IL6 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TLR4 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL23A protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of IL6 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TLR4 protein]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]; Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Berberine inhibits the reaction [Dietary Fats results in increased secretion of TNF protein]; Berberine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Berberine inhibits the reaction [Particulate Matter results in increased expression of TNF protein]		 CTD PMID:16391493 PMID:20656010 PMID:21095217 PMID:21867779 PMID:23523906 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Top1 topoisomerase (DNA) I decreases activity ISO Berberine results in decreased activity of TOP1 protein CTD PMID:23747414 NCBI chr 2:160,487,901...160,564,684
Ensembl chr 2:160,487,808...160,564,684 		JBrowse link
G Top2a topoisomerase (DNA) II alpha multiple interactions
affects response to substance		 ISO TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form]
TOP2A protein affects the susceptibility to Berberine		 CTD PMID:23747414 NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015 		JBrowse link
G Traf1 TNF receptor-associated factor 1 increases expression ISO Berberine results in increased expression of TRAF1 protein CTD PMID:20656010 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784 		JBrowse link
G Traf2 TNF receptor-associated factor 2 multiple interactions EXP Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased expression of TRAF2 mRNA]; Berberine inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with TNF protein] results in increased secretion of TRAF2 protein] CTD PMID:30240693 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Trim21 tripartite motif-containing 21 multiple interactions ISO Berberine promotes the reaction [IGF2BP3 protein binds to TRIM21 protein] CTD PMID:36822301 NCBI chr 7:102,207,127...102,214,689
Ensembl chr 7:102,207,128...102,214,693 		JBrowse link
G Trp53 transformation related protein 53 increases expression
multiple interactions		 ISO Berberine results in increased expression of TP53 mRNA; Berberine results in increased expression of TP53 protein
[Berberine co-treated with Niacinamide] results in increased expression of and results in increased acetylation of TP53 protein; Berberine results in increased phosphorylation of and results in increased acetylation of TP53 protein		 CTD PMID:20656010 PMID:26712469 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tstd1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 increases expression ISO Berberine results in increased expression of TSTD1 mRNA CTD PMID:27311644 NCBI chr 1:171,246,601...171,247,920
Ensembl chr 1:171,246,440...171,247,920 		JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO Berberine results in decreased expression of UBE2A mRNA CTD PMID:27311644 NCBI chr  X:36,137,948...36,147,875
Ensembl chr  X:36,064,828...36,147,875 		JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B decreases expression ISO Berberine results in decreased expression of UBE2B mRNA CTD PMID:27311644 NCBI chr11:51,875,965...51,894,972
Ensembl chr11:51,876,324...51,891,589 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) multiple interactions
increases expression		 EXP Berberine inhibits the reaction [Benzo(a)pyrene results in increased expression of UCP2 mRNA]
Berberine results in increased expression of UCP2 mRNA		 CTD PMID:28533128 PMID:37511356 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Berberine results in decreased expression of VEGFA protein CTD PMID:33325633 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Berberine results in increased expression of VEGFC mRNA CTD PMID:26478571 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131 		JBrowse link
manoalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO manoalide inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO manoalide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
N-(p-amylcinnamoyl)anthranilic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP
ISO		 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP3 protein]]		 CTD PMID:33309544 PMID:35395232 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP8 protein]] CTD PMID:35395232 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO		 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]
4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin results in increased activity of CASP9 protein]]		 CTD PMID:33309544 PMID:35395232 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Slc13a2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 multiple interactions ISO [4-amylcinnamoylanthranilic acid results in decreased activity of SLC13A2 protein] which results in decreased susceptibility to diethylene glycol metabolite CTD PMID:21856646 NCBI chr11:78,288,102...78,313,107
Ensembl chr11:78,287,913...78,313,043 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions
decreases activity		 ISO
EXP		 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Eicosapentaenoic Acid promotes the reaction [Cisplatin promotes the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]]]
4-amylcinnamoylanthranilic acid results in decreased activity of TRPM2 protein
4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; 4-amylcinnamoylanthranilic acid inhibits the reaction [Adenosine Diphosphate Ribose results in increased activity of TRPM2 protein]		 CTD PMID:18204483 PMID:30229906 PMID:33309544 PMID:34958835 PMID:35395232 NCBI chr10:77,743,556...77,805,746
Ensembl chr10:77,743,556...77,806,397 		JBrowse link
scalaradial term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:7575673 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP scalaradial inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein] CTD PMID:8113982 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO scalaradial inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; scalaradial inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:7575673 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO scalaradial inhibits the reaction [IL1B protein results in increased expression of TNF protein]; scalaradial inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:7575673 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
varespladib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F10 coagulation factor X multiple interactions ISO varespladib inhibits the reaction [micrurus venom results in decreased activity of F10 protein] CTD PMID:33197555 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO [Antivenins co-treated with varespladib] inhibits the reaction [micrurus venom results in increased expression of GPT protein] CTD PMID:34774704 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) decreases activity
multiple interactions		 ISO varespladib results in decreased activity of PLA2G2A protein
varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane A2 metabolite]; varespladib inhibits the reaction [PLA2G2A protein results in increased abundance of Thromboxane B2]		 CTD PMID:10027849 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
varespladib methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP1 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:19765281 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP2 protein] CTD PMID:19765281 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:19765281 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP9 protein] CTD PMID:19765281 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) multiple interactions ISO varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein] CTD PMID:19765281 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          enzyme inhibitor 19894
            EC 3.* (hydrolase) inhibitor 19243
              EC 3.1.* (ester hydrolase) inhibitor 15185
                EC 3.1.1.* (carboxylic ester hydrolase) inhibitor 12635
                  EC 3.1.1.4 (phospholipase A2) inhibitor 280
                    1-(all-cis-docosa-7,10,13,16-tetraenoyl)glycerol 0
                    AACOCF3 19
                    N-(p-amylcinnamoyl)anthranilic acid 5
                    alminoprofen 0
                    berberine 266
                    dysidine 0
                    manoalide 3
                    ochnaflavone 0
                    papyriflavonol A 0
                    scalaradial 4
                    thioetheramide PC 0
                    trans-benzylideneacetone 0
                    varespladib + 8
                    varespladib methyl 6
paths to the root