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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:citronellol
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Accession:CHEBI:50462 term browser browse the term
Definition:A monoterpenoid that is oct-6-ene substituted by a hydroxy group at position 1 and methyl groups at positions 3 and 7.
Synonyms:exact_synonym: 3,7-dimethyloct-6-en-1-ol
 related_synonym: 2,3-Dihydrogeraniol;   2,6-Dimethyl-2-octen-8-ol;   3,7-Dimethyl-6-octen-1-ol;   Cephrol;   Elenol;   Formula=C10H20O;   InChI=1S/C10H20O/c1-9(2)5-4-6-10(3)7-8-11/h5,10-11H,4,6-8H2,1-3H3;   InChIKey=QMVPMAAFGQKVCJ-UHFFFAOYSA-N;   SMILES=CC(CCO)CCC=C(C)C;   beta-Citronellol
 xref: Beilstein:1362474;   CAS:106-22-9
 xref_mesh: MESH:C007078
 xref: PMID:20964319;   Reaxys:1362474;   Wikipedia:Citronellol



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citronellol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO citronellol results in decreased activity of ABCB1 protein
[citronellol results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; citronellol inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
CTD PMID:15890377 PMID:16904803 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CCL3 mRNA] CTD PMID:31926054 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Fbp1 fructose-bisphosphatase 1 multiple interactions EXP citronellol inhibits the reaction [Streptozocin results in increased activity of FBP1 protein] CTD PMID:26944432 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP citronellol inhibits the reaction [Streptozocin results in increased activity of G6PC1 protein] CTD PMID:26944432 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP citronellol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein] CTD PMID:26944432 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A decreases activity ISO citronellol results in decreased activity of HTR3A protein CTD PMID:26456648 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Il10 interleukin 10 multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IL10 protein] CTD PMID:31926054 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 protein] CTD PMID:31926054 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
citronellol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NFKBIA mRNA]
CTD PMID:20506077 PMID:31926054 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO
EXP
citronellol results in decreased expression of NOS2 protein
citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NOS2 protein]
CTD PMID:20506077 PMID:31926054 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Olr1513 olfactory receptor 1513 affects binding ISO citronellol binds to OLFR43 protein
citronellol binds to OR1A1 protein
CTD PMID:17601748 NCBI chr10:59,058,941...59,059,879
Ensembl chr10:59,052,828...59,060,676
JBrowse link
G Olr1514 olfactory receptor 1514 affects binding ISO citronellol binds to OR1A2 protein CTD PMID:17601748 NCBI chr10:59,070,239...59,071,183
Ensembl chr10:59,069,404...59,075,457
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity ISO citronellol results in increased activity of PPARA protein CTD PMID:21597168 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
ISO citronellol results in increased activity of PPARG protein
citronellol inhibits the reaction [PPARG protein results in increased expression of PTGS2 mRNA]
CTD PMID:21597168 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
citronellol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; citronellol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 protein]
citronellol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; citronellol inhibits the reaction [PPARG protein results in increased expression of PTGS2 mRNA]
CTD PMID:20506077 PMID:21597168 PMID:31926054 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RELA protein] CTD PMID:31926054 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP citronellol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF protein] CTD PMID:31926054 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO citronellol binds to and results in increased activity of TRPV1 protein CTD PMID:20686244 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of citronellol CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
citronellol acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 affects activity ISO citronellyl acetate affects the activity of TRPM8 protein CTD PMID:23562495 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects activity ISO citronellyl acetate affects the activity of TRPV1 protein CTD PMID:23562495 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biochemical role 19671
          metabolite 19631
            eukaryotic metabolite 19358
              plant metabolite 17795
                citronellol 20
                  (R)-(+)-citronellol 0
                  (S)-(-)-citronellol 0
                  citronellol acetate 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            organic hydride 18675
                              organic fundamental parent 18657
                                hydrocarbon 18408
                                  terpene 13630
                                    monoterpene 3110
                                      monoterpenoid 1233
                                        citronellol 20
                                          (R)-(+)-citronellol 0
                                          (S)-(-)-citronellol 0
                                          citronellol acetate 2
paths to the root