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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:platelet glycoprotein-IIb/IIIa receptor antagonist
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Accession:CHEBI:50433 term browser browse the term
Definition:Antagonist of platelet surface glycoprotein-IIb/IIIa which has a key role in hemostasis and thrombosis such as platelet adhesion and aggregation.
Synonyms:related_synonym: GPIIb/IIIa antagonist;   GPIIb/IIIa antagonists;   fibrinogen receptor antagonist;   fibrinogen receptor antagonists;   glycoprotein-IIb/IIIa receptor antagonist;   glycoprotein-IIb/IIIa receptor antagonists;   platelet glycoprotein-IIb/IIIa receptor antagonists
 xref: Wikipedia:Glycoprotein_IIb/IIIa_inhibitors



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prasugrel hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of BDNF protein] CTD PMID:34174262 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of CREB1 protein] CTD PMID:34174262 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Mir22 microRNA 22 multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MIR22 mRNA] CTD PMID:34174262 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased sumoylation of NFKBIA protein] CTD PMID:34174262 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Prasugrel Hydrochloride binds to and results in decreased activity of P2RY12 protein CTD PMID:17681285 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SIRT1 protein] CTD PMID:34174262 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of UBE2I protein] CTD PMID:34174262 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        pharmacological role 18974
          antagonist 17005
            platelet glycoprotein-IIb/IIIa receptor antagonist 7
              fradafiban + 0
              lefradafiban 0
              prasugrel 0
              prasugrel hydrochloride 7
              tirofiban + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      application 19546
        pharmaceutical 19425
          drug 19425
            hematologic agent 4673
              platelet aggregation inhibitor 3510
                platelet glycoprotein-IIb/IIIa receptor antagonist 7
                  fradafiban + 0
                  lefradafiban 0
                  prasugrel 0
                  prasugrel hydrochloride 7
                  tirofiban + 0
paths to the root