CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxyaldehyde
Accession: CHEBI:50413
browse the term
Synonyms: related_synonym: hydroxyaldehydes
alt_id: CHEBI:24671; CHEBI:5798
xref: KEGG:C06461
G
Gsta4
glutathione S-transferase alpha 4
affects binding
EXP
(E)-4-hydroxynon-2-enal binds to Gsta4 protein
RGD
PMID:11018474
RGD:1641942
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
G
Gstp1
glutathione S-transferase pi 1
affects binding
EXP
(E)-4-hydroxynon-2-enal binds to Gstp1 protein
RGD
PMID:11018474
RGD:1641942
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ABCA1 mRNA
CTD
PMID:19191707
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
G
Abcc1
ATP binding cassette subfamily C member 1
affects binding increases expression multiple interactions
ISO
4-hydroxy-2-nonenal binds to ABCC1 protein 4-hydroxy-2-nonenal results in increased expression of ABCC1 mRNA [GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:15672542 PMID:19191707 PMID:21925487
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
affects export multiple interactions
EXP ISO
ABCC2 protein affects the export of 4-hydroxy-2-nonenal metabolite 4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]
CTD
PMID:12623073 PMID:19326901
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Acta1
actin, alpha 1, skeletal muscle
affects binding
EXP
4-hydroxy-2-nonenal binds to ACTA1 protein
CTD
PMID:15886073
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
G
Actb
actin, beta
affects binding
ISO
ACTB protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
G
Actn1
actinin, alpha 1
affects binding
ISO
ACTN1 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
G
Actn4
actinin alpha 4
affects binding
ISO
ACTN4 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
G
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ADH7 mRNA
CTD
PMID:19191707
NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
G
Adi1
acireductone dioxygenase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ADI1 mRNA
CTD
PMID:19191707
NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
G
Adora1
adenosine A1 receptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ADORA1 mRNA
CTD
PMID:12419474
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Adora2b
adenosine A2B receptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ADORA2B mRNA
CTD
PMID:19191707
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Adrb2
adrenoceptor beta 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ADRB2 mRNA
CTD
PMID:19191707
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
G
Ago2
argonaute RISC catalytic component 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AGO2 mRNA
CTD
PMID:19191707
NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
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Ago3
argonaute RISC catalytic component 3
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA 4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA
CTD
PMID:19191707
NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
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Agrn
agrin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AGRN mRNA
CTD
PMID:19191707
NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
G
Agt
angiotensinogen
affects binding multiple interactions
ISO
4-hydroxy-2-nonenal binds to AGT protein modified form; AGT protein modified form binds to 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal binds to and results in increased lipidation of AGT protein modified form; [AGT protein modified form results in increased chemical synthesis of Lipid Peroxides] which results in increased abundance of 4-hydroxy-2-nonenal; [Ascorbic Acid co-treated with Copper Sulfate] promotes the reaction [AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]
CTD
PMID:20977208 PMID:26111765 PMID:31144504
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Ahsa2
activator of HSP90 ATPase homolog 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of AHSA2 mRNA
CTD
PMID:19191707
NCBI chr14:97,476,304...97,485,725
Ensembl chr14:97,476,817...97,485,657
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Aifm1
apoptosis inducing factor, mitochondria associated 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of AIFM1 mRNA
CTD
PMID:19191707
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Akna
AT-hook transcription factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AKNA mRNA
CTD
PMID:19191707
NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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Akr1a1
aldo-keto reductase family 1 member A1
increases reduction increases expression
ISO
AKR1A1 protein results in increased reduction of 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased expression of AKR1A1 mRNA
CTD
PMID:10510318 PMID:19191707
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
G
Akr1b1
aldo-keto reductase family 1 member B1
affects reduction increases reduction
ISO
AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal; AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite
CTD
PMID:9890881 PMID:10510318 PMID:11306073 PMID:21329684
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1b10
aldo-keto reductase family 1 member B10
increases reduction multiple interactions increases metabolic processing
ISO
AKR1B10 protein results in increased reduction of 4-hydroxy-2-nonenal Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]
CTD
PMID:19013440 PMID:21329684 PMID:27417252
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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Akr1c3
aldo-keto reductase family 1, member C3
increases expression increases response to substance multiple interactions
ISO
4-hydroxy-2-nonenal results in increased expression of AKR1C3 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR1C3 protein AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
CTD
PMID:22964423 PMID:30849339
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Akr7a2
aldo-keto reductase family 7, member A2
decreases response to substance affects response to substance increases response to substance multiple interactions increases expression
ISO
AKR7A2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal AKR7A2 protein affects the susceptibility to 4-hydroxy-2-nonenal AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal] 4-hydroxy-2-nonenal results in increased expression of AKR7A2 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR7A2 protein
CTD
PMID:22001351 PMID:22964423 PMID:30849339
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
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Akt1
AKT serine/threonine kinase 1
affects response to substance multiple interactions increases activity decreases phosphorylation
EXP ISO
AKT1 protein affects the susceptibility to 4-hydroxy-2-nonenal AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein] 4-hydroxy-2-nonenal results in increased activity of AKT1 protein 4-hydroxy-2-nonenal results in decreased phosphorylation of AKT1 protein
CTD
PMID:18805481 PMID:23845594 PMID:24825450
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Alb
albumin
multiple interactions
ISO
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein; [ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]; sulforaphane inhibits the reaction [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene]
CTD
PMID:33007382
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases metabolic processing multiple interactions increases oxidation
ISO
ALDH1A1 protein results in increased metabolism of 4-hydroxy-2-nonenal [APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal ALDH1A1 protein results in increased oxidation of 4-hydroxy-2-nonenal
CTD
PMID:21256123 PMID:21967605 PMID:22339434
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions increases oxidation
ISO
[APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal ALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein; ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]
CTD
PMID:21967605 PMID:22339434 PMID:25263579
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Aldh3a1
aldehyde dehydrogenase 3 family, member A1
decreases response to substance affects metabolic processing affects response to substance increases metabolic processing multiple interactions increases oxidation
ISO EXP
ALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal ALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenal ALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenal ALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenal [APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal ALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenal
CTD
PMID:11018474 PMID:11306050 PMID:15905174 PMID:21256123 PMID:21967605 PMID:22339434 More...
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
G
Aldh3b1
aldehyde dehydrogenase 3 family, member B1
affects binding decreases response to substance
ISO
4-hydroxy-2-nonenal binds to ALDH3B1 protein ALDH3B1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:20699116
NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
G
Aldh6a1
aldehyde dehydrogenase 6 family, member A1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ALDH6A1 mRNA
CTD
PMID:19191707
NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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Aldh7a1
aldehyde dehydrogenase 7 family, member A1
increases metabolic processing decreases response to substance
ISO
ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:21338592
NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
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Aldoa
aldolase, fructose-bisphosphate A
affects binding
ISO
ALDOA protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Aldoc
aldolase, fructose-bisphosphate C
multiple interactions
ISO
Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein]
CTD
PMID:20889679
NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Alox5
arachidonate 5-lipoxygenase
multiple interactions
ISO
ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]
CTD
PMID:19837106
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Alox5ap
arachidonate 5-lipoxygenase activating protein
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ALOX5AP mRNA
CTD
PMID:19191707
NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
G
Alpk1
alpha-kinase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ALPK1 mRNA
CTD
PMID:19191707
NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157
G
Als2
alsin Rho guanine nucleotide exchange factor ALS2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ALS2 mRNA
CTD
PMID:19191707
NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737
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Amph
amphiphysin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AMPH mRNA
CTD
PMID:12419474
NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315
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Anln
anillin, actin binding protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ANLN mRNA
CTD
PMID:19191707
NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
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Anp32a
acidic nuclear phosphoprotein 32 family member A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ANP32A mRNA
CTD
PMID:19191707
NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443
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Aoah
acyloxyacyl hydrolase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AOAH mRNA
CTD
PMID:19191707
NCBI chr17:43,808,110...44,049,458
Ensembl chr17:43,809,638...44,049,148
G
Aox1
aldehyde oxidase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of AOX1 mRNA
CTD
PMID:19191707
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Ap1s3
adaptor related protein complex 1 subunit sigma 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AP1S3 mRNA
CTD
PMID:19191707
NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798
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Apc
APC regulator of WNT signaling pathway
decreases expression multiple interactions affects response to substance affects oxidation
ISO
4-hydroxy-2-nonenal results in decreased expression of APC mRNA [APC protein affects the oxidation of 4-hydroxy-2-nonenal] which affects the abundance of 4-hydroxynonenoic acid; [APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of GSTA4 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal APC protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:12419474 PMID:21967605
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA
CTD
PMID:19191707
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Apoa1
apolipoprotein A1
affects binding
ISO
4-hydroxy-2-nonenal binds to APOA1 protein
CTD
PMID:18778096
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Apod
apolipoprotein D
decreases abundance
ISO
APOD protein results in decreased abundance of 4-hydroxy-2-nonenal
CTD
PMID:28182653
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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App
amyloid beta precursor protein
decreases expression multiple interactions
ISO
4-hydroxy-2-nonenal results in decreased expression of APP mRNA [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; Deferoxamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]
CTD
PMID:12419474 PMID:17964426
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Arhgap11a
Rho GTPase activating protein 11A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ARHGAP11A mRNA
CTD
PMID:19191707
NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
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Arhgap22
Rho GTPase activating protein 22
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ARHGAP22 mRNA
CTD
PMID:19191707
NCBI chr16:8,473,806...8,631,552
Ensembl chr16:8,476,306...8,631,548
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Arhgap27
Rho GTPase activating protein 27
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ARHGAP27 mRNA
CTD
PMID:19191707
NCBI chr10:88,280,470...88,313,225
Ensembl chr10:88,280,455...88,313,185
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Arhgap5
Rho GTPase activating protein 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ARHGAP5 mRNA
CTD
PMID:12419474
NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660
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Arhgdia
Rho GDP dissociation inhibitor alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ARHGDIA mRNA
CTD
PMID:12419474
NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
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Arhgef3
Rho guanine nucleotide exchange factor 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNA
CTD
PMID:19191707
NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
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Arid5a
AT-rich interaction domain 5A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ARID5A mRNA
CTD
PMID:19191707
NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
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Arrdc3
arrestin domain containing 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ARRDC3 mRNA
CTD
PMID:19191707
NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
G
Asf1b
anti-silencing function 1B histone chaperone
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ASF1B mRNA 4-hydroxy-2-nonenal results in increased expression of ASF1B mRNA
CTD
PMID:19191707
NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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Aspm
assembly factor for spindle microtubules
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ASPM mRNA
CTD
PMID:19191707
NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
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Atad5
ATPase family, AAA domain containing 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ATAD5 mRNA
CTD
PMID:19191707
NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845
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Atf3
activating transcription factor 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ATF3 protein
CTD
PMID:19041636
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atf4
activating transcription factor 4
increases expression multiple interactions
EXP
4-hydroxy-2-nonenal results in increased expression of ATF4 mRNA; 4-hydroxy-2-nonenal results in increased expression of ATF4 protein Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]
CTD
PMID:24291486
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atf6
activating transcription factor 6
increases expression multiple interactions
EXP
4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]
CTD
PMID:24291486
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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Atg5
autophagy related 5
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ATG5 mRNA
CTD
PMID:35550146
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Atg7
autophagy related 7
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ATG7 mRNA
CTD
PMID:35550146
NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
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Atm
ATM serine/threonine kinase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ATM mRNA
CTD
PMID:19191707
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atp1b3
ATPase Na+/K+ transporting subunit beta 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ATP1B3 mRNA
CTD
PMID:12419474
NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
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Atp5f1a
ATP synthase F1 subunit alpha
affects binding
ISO
4-hydroxy-2-nonenal binds to ATP5F1A protein
CTD
PMID:19374891
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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Atp6v1a
ATPase H+ transporting V1 subunit A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ATP6V1A mRNA
CTD
PMID:19191707
NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
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Atr
ATR serine/threonine kinase
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ATR mRNA 4-hydroxy-2-nonenal results in increased expression of ATR mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Avil
advillin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AVIL mRNA
CTD
PMID:19191707
NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071
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B2m
beta-2 microglobulin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of B2M mRNA
CTD
PMID:19191707
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Babam2
BRISC and BRCA1 A complex member 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BABAM2 mRNA
CTD
PMID:19191707
NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
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Bad
BCL2-associated agonist of cell death
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BAD mRNA 4-hydroxy-2-nonenal results in increased expression of BAD protein
CTD
PMID:12419474 PMID:24825450
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Batf2
basic leucine zipper ATF-like transcription factor 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BATF2 mRNA
CTD
PMID:19191707
NCBI chr 1:203,467,291...203,479,428
Ensembl chr 1:203,468,097...203,475,889
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Bax
BCL2 associated X, apoptosis regulator
decreases expression increases expression
ISO EXP
4-hydroxy-2-nonenal results in decreased expression of BAX mRNA 4-hydroxy-2-nonenal results in increased expression of BAX protein
CTD
PMID:12419474 PMID:15607904 PMID:21187080 PMID:24825450
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bbc3
Bcl-2 binding component 3
multiple interactions increases expression
EXP
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]
CTD
PMID:24291486
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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Bbx
BBX high mobility group box domain containing
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BBX mRNA
CTD
PMID:19191707
NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251
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Bcar3
BCAR3 adaptor protein, NSP family member
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BCAR3 mRNA
CTD
PMID:19191707
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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Bcl2a1
BCL2-related protein A1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BCL2A1B mRNA
CTD
PMID:19191707
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BCL2L1 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bcl2l11
Bcl2-like 11
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BCL2L11 mRNA
CTD
PMID:19191707
NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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Bcl3
BCL3, transcription coactivator
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BCL3 mRNA
CTD
PMID:19191707
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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Bcl6
BCL6, transcription repressor
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA
CTD
PMID:19191707
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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Bdnf
brain-derived neurotrophic factor
decreases expression multiple interactions
EXP
4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]
CTD
PMID:16337876
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bgn
biglycan
multiple interactions
ISO
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal
CTD
PMID:35234341
NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461
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Bhlhe40
basic helix-loop-helix family, member e40
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BHLHE40 mRNA
CTD
PMID:19191707
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Bhlhe41
basic helix-loop-helix family, member e41
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BHLHE41 mRNA
CTD
PMID:19191707
NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468
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Bid
BH3 interacting domain death agonist
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BID mRNA
CTD
PMID:19191707
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
G
Birc5
baculoviral IAP repeat-containing 5
increases expression decreases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BIRC5 mRNA 4-hydroxy-2-nonenal results in decreased expression of BIRC5 mRNA
CTD
PMID:19191707
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Blm
BLM RecQ like helicase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BLM mRNA
CTD
PMID:19191707
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Blvrb
biliverdin reductase B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BLVRB mRNA
CTD
PMID:19191707
NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
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Bmp1
bone morphogenetic protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BMP1 mRNA
CTD
PMID:12419474
NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
G
Bnip3
BCL2 interacting protein 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BNIP3 mRNA
CTD
PMID:12419474
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
G
Braf
B-Raf proto-oncogene, serine/threonine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BRAF mRNA
CTD
PMID:12419474
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
G
Bub1
BUB1 mitotic checkpoint serine/threonine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BUB1 mRNA
CTD
PMID:19191707
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
G
Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of BUB1B mRNA
CTD
PMID:19191707
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
G
Bzw1
basic leucine zipper and W2 domains 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of BZW1 mRNA
CTD
PMID:19191707
NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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C5ar1
complement C5a receptor 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of C5AR1 mRNA
CTD
PMID:19191707
NCBI chr 1:76,948,622...76,959,826
G
Cacna1a
calcium voltage-gated channel subunit alpha1 A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CACNA1A mRNA
CTD
PMID:19191707
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Cadps
calcium dependent secretion activator
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CADPS mRNA
CTD
PMID:19191707
NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
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Calca
calcitonin-related polypeptide alpha
increases secretion
EXP
4-hydroxy-2-nonenal results in increased secretion of CALCA protein
CTD
PMID:17684094
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calcoco1
calcium binding and coiled coil domain 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CALCOCO1 mRNA
CTD
PMID:19191707
NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422
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Calr3
calreticulin 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CALR3 mRNA
CTD
PMID:19191707
NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015
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Camk1d
calcium/calmodulin-dependent protein kinase ID
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CAMK1D mRNA
CTD
PMID:19191707
NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
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Cap1
cyclase associated actin cytoskeleton regulatory protein 1
affects binding
ISO
CAP1 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
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Capn2
calpain 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CAPN2 mRNA
CTD
PMID:12419474
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Capns1
calpain, small subunit 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CAPNS1 mRNA
CTD
PMID:12419474
NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795
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Capzb
capping actin protein of muscle Z-line subunit beta
affects binding
ISO
CAPZB protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
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Car12
carbonic anhydrase 12
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CAR12 mRNA
CTD
PMID:19191707
NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
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Car2
carbonic anhydrase 2
affects binding
ISO
CA2 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Carhsp1
calcium regulated heat stable protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CARHSP1 mRNA
CTD
PMID:19191707
NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
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Cask
calcium/calmodulin dependent serine protein kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CASK mRNA
CTD
PMID:12419474
NCBI chr X:8,899,500...9,243,014
Ensembl chr X:8,899,833...9,238,694
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Casp1
caspase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CASP1 mRNA
CTD
PMID:19191707
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
multiple interactions increases activity increases cleavage
ISO EXP
4-hydroxy-2-nonenal results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein] Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein] 4-hydroxy-2-nonenal results in increased cleavage of CASP3 protein
CTD
PMID:11488593 PMID:16322078 PMID:16337876 PMID:17263905 PMID:19326901 PMID:20114059 PMID:21187080 PMID:24291486 PMID:24825450 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4
caspase 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CASP4 mRNA
CTD
PMID:19191707
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp7
caspase 7
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CASP7 mRNA
CTD
PMID:19191707
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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Casp8
caspase 8
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA
CTD
PMID:12419474
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity multiple interactions
ISO EXP
4-hydroxy-2-nonenal results in increased activity of CASP9 protein pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]
CTD
PMID:16322078 PMID:17263905 PMID:21187080 PMID:24825450
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CAT mRNA
CTD
PMID:19191707 PMID:24423726
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cblb
Cbl proto-oncogene B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CBLB mRNA
CTD
PMID:12419474
NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
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Ccl17
C-C motif chemokine ligand 17
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL17 mRNA 4-hydroxy-2-nonenal results in increased expression of CCL17 mRNA
CTD
PMID:19191707
NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL2 mRNA
CTD
PMID:19191707
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl22
C-C motif chemokine ligand 22
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL22 mRNA
CTD
PMID:19191707
NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
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Ccl3
C-C motif chemokine ligand 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL3 mRNA
CTD
PMID:12419474
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL4 mRNA
CTD
PMID:19191707
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
G
Ccl5
C-C motif chemokine ligand 5
multiple interactions decreases expression
ISO
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein] 4-hydroxy-2-nonenal results in decreased expression of CCL5 mRNA
CTD
PMID:19191707 PMID:19627980
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccl7
C-C motif chemokine ligand 7
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL7 mRNA
CTD
PMID:19191707
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccl9
C-C motif chemokine ligand 9
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCL6 mRNA
CTD
PMID:19191707
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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Ccna2
cyclin A2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCNA2 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCNB1 mRNA
CTD
PMID:19191707
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnd1
cyclin D1
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CCND1] 4-hydroxy-2-nonenal results in increased expression of CCND1; 4-hydroxy-2-nonenal results in increased expression of CCND1 mRNA
CTD
PMID:16328008 PMID:19191707
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccnd2
cyclin D2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCND2 protein
CTD
PMID:15607904
NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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Ccnd3
cyclin D3
multiple interactions
ISO
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]
CTD
PMID:33007382
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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Ccnf
cyclin F
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCNF mRNA
CTD
PMID:19191707
NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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Ccng1
cyclin G1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CCNG1 mRNA
CTD
PMID:19191707
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
G
Ccng2
cyclin G2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCNG2 mRNA
CTD
PMID:19191707
NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
G
Ccnk
cyclin K
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCNK mRNA
CTD
PMID:12419474
NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
G
Ccnt1
cyclin T1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNA
CTD
PMID:12419474
NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871
G
Ccr1
C-C motif chemokine receptor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 8:123,556,286...123,561,841
G
Cd14
CD14 molecule
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CD14 mRNA
CTD
PMID:19191707
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
G
Cd300a
Cd300a molecule
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CD300A mRNA
CTD
PMID:19191707
NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
G
Cd300lb
CD300 molecule-like family member b
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CD300LB mRNA
CTD
PMID:19191707
NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790
G
Cd300lf
Cd300 molecule-like family member F
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CD300LF mRNA
CTD
PMID:19191707
NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041
G
Cd36
CD36 molecule
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CD36 mRNA
CTD
PMID:19191707
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
G
Cd40
CD40 molecule
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CD40 mRNA
CTD
PMID:19191707
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
G
Cd44
CD44 molecule
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CD44 mRNA
CTD
PMID:19191707
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
G
Cd47
Cd47 molecule
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CD47 mRNA
CTD
PMID:12419474
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
G
Cd83
CD83 molecule
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CD83 mRNA
CTD
PMID:19191707
NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
G
Cd86
CD86 molecule
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CD86 mRNA
CTD
PMID:19191707
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
G
Cdc20
cell division cycle 20
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
G
Cdc25a
cell division cycle 25A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
G
Cdc25c
cell division cycle 25C
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDC25C mRNA
CTD
PMID:19191707
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
G
Cdca2
cell division cycle associated 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDCA2 mRNA
CTD
PMID:19191707
NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
G
Cdh1
cadherin 1
multiple interactions
ISO
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in decreased expression of CDH1 protein
CTD
PMID:34503147
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Cdh2
cadherin 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNA
CTD
PMID:12419474
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
G
Cdh3
cadherin 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDH3 mRNA
CTD
PMID:12419474
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
G
Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
4-hydroxy-2-nonenal binds to and results in increased alkylation of and results in decreased activity of CDK2 protein
CTD
PMID:26910110
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
G
Cdk6
cyclin-dependent kinase 6
increases expression multiple interactions
ISO
4-hydroxy-2-nonenal results in increased expression of CDK6 mRNA [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]
CTD
PMID:19191707 PMID:33007382
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
G
Cdk9
cyclin-dependent kinase 9
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDK9 mRNA
CTD
PMID:12419474
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CDKN1A protein
CTD
PMID:15607904
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1c
cyclin-dependent kinase inhibitor 1C
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDKN1C mRNA
CTD
PMID:12419474
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
G
Cdkn2d
cyclin dependent kinase inhibitor 2D
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CDKN2D mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
G
Cebpa
CCAAT/enhancer binding protein alpha
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CEBPA mRNA
CTD
PMID:19191707
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
G
Cenpa
centromere protein A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CENPA mRNA
CTD
PMID:19191707
NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
G
Cep290
centrosomal protein 290
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CEP290 mRNA
CTD
PMID:19191707
NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392
G
Ces1d
carboxylesterase 1D
decreases activity
ISO
4-hydroxy-2-nonenal results in decreased activity of CES1 protein
CTD
PMID:21878322
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
G
Ces2h
carboxylesterase 2H
increases activity
ISO
4-hydroxy-2-nonenal results in increased activity of CES2 protein
CTD
PMID:21878322
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
G
Cfb
complement factor B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CFB mRNA
CTD
PMID:19191707
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
G
Cfl1
cofilin 1
affects binding
ISO
CFL1 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
G
Chek1
checkpoint kinase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA
CTD
PMID:19191707
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
G
Chml
CHM like Rab escort protein
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CHML mRNA
CTD
PMID:19191707
NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862
G
Cilk1
ciliogenesis associated kinase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CILK1 mRNA
CTD
PMID:19191707
NCBI chr 8:78,984,075...79,042,695
Ensembl chr 8:78,984,258...79,042,691
G
Cish
cytokine inducible SH2-containing protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CISH mRNA
CTD
PMID:19191707
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
G
Cks1b
CDC28 protein kinase regulatory subunit 1B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CKS1B mRNA
CTD
PMID:19191707
NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
G
Cks2
CDC28 protein kinase regulatory subunit 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CKS2 mRNA
CTD
PMID:19191707
NCBI chr17:13,570,611...13,575,770
G
Cldn11
claudin 11
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CLDN11 mRNA
CTD
PMID:19191707
NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
G
Clec12a
C-type lectin domain family 12, member A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CLEC12A mRNA
CTD
PMID:19191707
NCBI chr 4:162,798,125...162,816,757
Ensembl chr 4:162,798,125...162,816,753
G
Clec4a
C-type lectin domain family 4, member A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CLEC4N mRNA
CTD
PMID:19191707
NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
G
Clec4d
C-type lectin domain family 4, member D
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CLEC4D mRNA
CTD
PMID:19191707
NCBI chr 4:156,589,591...156,599,279
Ensembl chr 4:156,589,792...156,598,848
G
Clec5a
C-type lectin domain containing 5A
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CLEC5A mRNA 4-hydroxy-2-nonenal results in increased expression of CLEC5A mRNA
CTD
PMID:19191707
NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
G
Clk3
CDC-like kinase 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CLK3 mRNA
CTD
PMID:12419474
NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181
G
Col1a1
collagen type I alpha 1 chain
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of COL1A1 mRNA; 4-hydroxy-2-nonenal results in increased expression of COL1A1 protein
CTD
PMID:14672615
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
G
Comt
catechol-O-methyltransferase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of COMT mRNA
CTD
PMID:12419474
NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
G
Cp
ceruloplasmin
decreases expression affects abundance
ISO
4-hydroxy-2-nonenal results in decreased expression of CP mRNA CP protein affects the abundance of 4-hydroxy-2-nonenal
CTD
PMID:12572680 PMID:19191707
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
G
Cpe
carboxypeptidase E
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CPE mRNA
CTD
PMID:12419474
NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
G
Creb1
cAMP responsive element binding protein 1
decreases expression increases phosphorylation
ISO
4-hydroxy-2-nonenal results in decreased expression of CREB1 mRNA 4-hydroxy-2-nonenal results in increased phosphorylation of CREB1 protein
CTD
PMID:12419474 PMID:16337876
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Crebbp
CREB binding protein
multiple interactions
EXP
CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]
CTD
PMID:16337876
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
G
Creg1
cellular repressor of E1A-stimulated genes 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CREG1 mRNA
CTD
PMID:19191707
NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
G
Crot
carnitine O-octanoyltransferase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CROT mRNA
CTD
PMID:19191707
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
G
Cry1
cryptochrome circadian regulator 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CRY1 mRNA
CTD
PMID:19191707
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
G
Cry2
cryptochrome circadian regulator 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CRY2 mRNA
CTD
PMID:19191707
NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
G
Cryz
crystallin zeta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CRYZ mRNA
CTD
PMID:12419474
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
G
Csf1r
colony stimulating factor 1 receptor
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA
CTD
PMID:19191707
NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
G
Csf2
colony stimulating factor 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CSF2 mRNA
CTD
PMID:19191707
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
G
Csf3
colony stimulating factor 3
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CSF3 mRNA 4-hydroxy-2-nonenal results in increased expression of CSF3 mRNA; 4-hydroxy-2-nonenal results in increased expression of CSF3 protein
CTD
PMID:19191707
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
G
Csnk1g2
casein kinase 1, gamma 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CSNK1G2 mRNA
CTD
PMID:12419474
NCBI chr 7:9,076,739...9,095,082
Ensembl chr 7:9,076,740...9,095,052
G
Csrnp1
cysteine and serine rich nuclear protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of AXUD1 mRNA
CTD
PMID:19191707
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
G
Ctnnb1
catenin beta 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CTNNB1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 protein
CTD
PMID:12419474 PMID:24825450
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
G
Ctsd
cathepsin D
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]
CTD
PMID:35550146
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
G
Ctsl
cathepsin L
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CTSL mRNA
CTD
PMID:12419474
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
G
Cttn
cortactin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CTTN mRNA
CTD
PMID:12419474
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
G
Cux1
cut-like homeobox 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNA
CTD
PMID:12419474
NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866
G
Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions
ISO
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein]
CTD
PMID:19627980
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
G
Cxcl14
C-X-C motif chemokine ligand 14
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CXCL14 mRNA
CTD
PMID:19191707
NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
G
Cxcl3
C-X-C motif chemokine ligand 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CXCL1 mRNA
CTD
PMID:19191707
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of CXCR4 mRNA
CTD
PMID:19191707
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Cybb
cytochrome b-245 beta chain
increases abundance
ISO
CYBB protein results in increased abundance of 4-hydroxy-2-nonenal
CTD
PMID:19417757
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
G
Cycs
cytochrome c, somatic
affects localization multiple interactions
ISO EXP
4-hydroxy-2-nonenal affects the localization of CYCS protein pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]
CTD
PMID:16322078 PMID:17263905 PMID:21187080
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[CYP1A2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP1A2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal
CTD
PMID:21766881
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CYP1B1 mRNA
CTD
PMID:12419474
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
[CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2B6 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal
CTD
PMID:21766881
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
[CYP2C29 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2C29 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2C29 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal
CTD
PMID:21766881
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
multiple interactions
ISO
[CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2J2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal
CTD
PMID:21766881
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal; [CYP3A4 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid
CTD
PMID:21766881
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cysltr1
cysteinyl leukotriene receptor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA
CTD
PMID:19191707
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
G
Cyth4
cytohesin 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of CYTH4 mRNA
CTD
PMID:19191707
NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741
G
Dap
death-associated protein
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of DAP mRNA
CTD
PMID:19191707
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
G
Dapk1
death associated protein kinase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNA
CTD
PMID:12419474
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
G
Dbf4
DBF4-CDC7 kinase regulatory subunit
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DBF4 mRNA
CTD
PMID:19191707
NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066
G
Dcn
decorin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DCN mRNA
CTD
PMID:19191707
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
G
Ddit3
DNA-damage inducible transcript 3
increases expression multiple interactions
EXP
4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA; 4-hydroxy-2-nonenal results in increased expression of DDIT3 protein Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]
CTD
PMID:24291486
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ddit4
DNA-damage-inducible transcript 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DDIT4 mRNA
CTD
PMID:19191707
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
G
Ddr2
discoidin domain receptor tyrosine kinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNA
CTD
PMID:12419474
NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
G
Denr
density regulated reinitiation and release factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DENR mRNA
CTD
PMID:19191707
NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
G
Dffa
DNA fragmentation factor subunit alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DFFA mRNA
CTD
PMID:12419474
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
G
Dffb
DNA fragmentation factor subunit beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DFFB mRNA
CTD
PMID:12419474
NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
G
Dgkh
diacylglycerol kinase, eta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DGKH mRNA
CTD
PMID:19191707
NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706
G
Dhx58
DEXH-box helicase 58
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DHX58 mRNA
CTD
PMID:19191707
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
G
Dio2
iodothyronine deiodinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA
CTD
PMID:19191707
NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
G
Dlgap5
DLG associated protein 5
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DLGAP5 mRNA 4-hydroxy-2-nonenal results in increased expression of DLGAP5 mRNA
CTD
PMID:19191707
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
G
Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of DNAJB4 mRNA
CTD
PMID:19191707
NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
G
Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DNAJC3 mRNA
CTD
PMID:12419474
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
G
Dnase2
deoxyribonuclease 2, lysosomal
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of DNASE2A mRNA
CTD
PMID:19191707
NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376
G
Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DNPH1 mRNA
CTD
PMID:12419474
NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
G
Dpysl2
dihydropyrimidinase-like 2
affects binding
ISO
4-hydroxy-2-nonenal binds to DPYSL2 protein
CTD
PMID:19374891
NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
G
Drd2
dopamine receptor D2
decreases expression
EXP
4-hydroxy-2-nonenal results in decreased expression of DRD2 protein
CTD
PMID:20570720
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Dst
dystonin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of DST mRNA
CTD
PMID:12419474
NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
G
Dynlt3
dynein light chain Tctex-type 3
affects binding
ISO
DYNLT3 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr X:13,327,933...13,337,139
Ensembl chr X:13,327,892...13,337,139
G
E2f1
E2F transcription factor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of E2F1 mRNA
CTD
PMID:12419474
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
E2f2
E2F transcription factor 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of E2F2 mRNA
CTD
PMID:19191707
NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
G
E2f8
E2F transcription factor 8
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of E2F8 mRNA
CTD
PMID:19191707
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
G
Echdc3
enoyl CoA hydratase domain containing 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ECHDC3 mRNA
CTD
PMID:19191707
NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516
G
Edn1
endothelin 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA
CTD
PMID:19191707
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Eef2
eukaryotic translation elongation factor 2
decreases expression
EXP
4-hydroxy-2-nonenal results in decreased expression of EEF2 protein
CTD
PMID:16469450
NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
G
Efna4
ephrin A4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EFNA4 mRNA
CTD
PMID:12419474
NCBI chr 2:174,748,729...174,752,979
Ensembl chr 2:174,748,724...174,752,979
G
Eid3
EP300 interacting inhibitor of differentiation 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of EID3 mRNA
CTD
PMID:19191707
NCBI chr 7:20,860,073...20,861,395
G
Eif2a
eukaryotic translation initiation factor 2A
increases phosphorylation
ISO
4-hydroxy-2-nonenal results in increased phosphorylation of EIF2A protein
CTD
PMID:19041636
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
G
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA
CTD
PMID:19191707
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases phosphorylation
ISO
4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:19041636
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
G
Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
multiple interactions increases phosphorylation
EXP
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:24291486
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
G
Eif4e
eukaryotic translation initiation factor 4E
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of EIF4E mRNA
CTD
PMID:19191707
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
G
Eif4e2
eukaryotic translation initiation factor 4E family member 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of EIF4E2 mRNA
CTD
PMID:19191707
NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
increases phosphorylation
EXP
4-hydroxy-2-nonenal results in increased phosphorylation of EIF4EBP1 protein
CTD
PMID:9890986
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
G
Eif5a
eukaryotic translation initiation factor 5A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of EIF5A mRNA
CTD
PMID:19191707
NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
G
Elk1
ETS transcription factor ELK1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ELK1 mRNA
CTD
PMID:12419474
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
G
Eloc
elongin C
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ELOC mRNA
CTD
PMID:12419474
NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890
G
Elp1
elongator acetyltransferase complex subunit 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ELP1 mRNA
CTD
PMID:12419474
NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
G
Eme1
essential meiotic structure-specific endonuclease 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EME1 mRNA
CTD
PMID:19191707
NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435
G
Eno1
enolase 1
affects binding
ISO
4-hydroxy-2-nonenal binds to ENO1 protein
CTD
PMID:19374891
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
G
Ephx1
epoxide hydrolase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of EPHX1 mRNA
CTD
PMID:19191707
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Eps15
epidermal growth factor receptor pathway substrate 15
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EPS15 mRNA
CTD
PMID:12419474
NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
G
Eps8
EGFR pathway substrate 8, signaling adaptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EPS8 mRNA
CTD
PMID:12419474
NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
G
Epsti1
epithelial stromal interaction 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EPSTI1 mRNA
CTD
PMID:19191707
NCBI chr15:53,283,964...53,382,192
Ensembl chr15:53,284,216...53,382,191
G
Erbb2
erb-b2 receptor tyrosine kinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERBB2 mRNA
CTD
PMID:12419474
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
G
Erbb4
erb-b2 receptor tyrosine kinase 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNA
CTD
PMID:12419474
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
G
Ercc1
ERCC excision repair 1, endonuclease non-catalytic subunit
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERCC1 mRNA
CTD
PMID:19191707
NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
G
Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERCC2 mRNA
CTD
PMID:12419474
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
G
Ercc5
ERCC excision repair 5, endonuclease
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA
CTD
PMID:12419474
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
G
Ercc6l
ERCC excision repair 6 like, spindle assembly checkpoint helicase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERCC6L mRNA
CTD
PMID:19191707
NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756
G
Ern1
endoplasmic reticulum to nucleus signaling 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ERN1 mRNA
CTD
PMID:19191707
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
G
Espl1
extra spindle pole bodies like 1, separase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ESPL1 mRNA
CTD
PMID:19191707
NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
G
Ets1
ETS proto-oncogene 1, transcription factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ETS1 mRNA
CTD
PMID:12419474
NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
G
Ets2
ETS proto-oncogene 2, transcription factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ETS2 mRNA
CTD
PMID:12419474
NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
G
Etv3
ETS variant transcription factor 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ETV3 mRNA
CTD
PMID:12419474
NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314
G
Etv6
ETS variant transcription factor 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ETV6 mRNA
CTD
PMID:12419474
NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
G
Ezr
ezrin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of EZR mRNA
CTD
PMID:12419474
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
G
F10
coagulation factor X
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of F10 mRNA
CTD
PMID:19191707
NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
G
F2r
coagulation factor II (thrombin) receptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of F2R mRNA
CTD
PMID:12419474
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
G
F3
coagulation factor III, tissue factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of F3 mRNA
CTD
PMID:19191707
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Fancd2
FA complementation group D2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FANCD2 mRNA
CTD
PMID:19191707
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
G
Fastk
Fas-activated serine/threonine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FASTK mRNA
CTD
PMID:12419474
NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430
G
Fbxl17
F-box and leucine-rich repeat protein 17
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FBXL17 mRNA
CTD
PMID:19191707
NCBI chr 9:102,780,573...103,206,978
Ensembl chr 9:102,782,440...103,208,950
G
Fbxl20
F-box and leucine-rich repeat protein 20
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FBXL20 mRNA 4-hydroxy-2-nonenal results in increased expression of FBXL20 mRNA
CTD
PMID:19191707
NCBI chr10:83,080,568...83,143,680
Ensembl chr10:83,086,551...83,144,162
G
Fbxo15
F-box protein 15
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FBXO15 mRNA
CTD
PMID:19191707
NCBI chr18:78,319,577...78,634,695
Ensembl chr18:78,319,534...78,390,765
G
Fbxo22
F-box protein 22
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FBXO22 mRNA
CTD
PMID:19191707
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
G
Fbxo30
F-box protein 30
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FBXO30 mRNA
CTD
PMID:19191707
NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
G
Fbxo31
F-box protein 31
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FBXO31 mRNA
CTD
PMID:19191707
NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010
G
Fbxo39
F-box protein 39
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FBXO39 mRNA
CTD
PMID:19191707
NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906
G
Fbxo5
F-box protein 5
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FBXO5 mRNA 4-hydroxy-2-nonenal results in increased expression of FBXO5 mRNA
CTD
PMID:19191707
NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
G
Fcgr1a
Fc gamma receptor 1A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FCGR1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of FCGR1A mRNA
CTD
PMID:19191707
NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
G
Fcgr2b
Fc gamma receptor 2B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FCGR2B mRNA
CTD
PMID:19191707
NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
G
Fech
ferrochelatase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FECH mRNA
CTD
PMID:12419474
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
G
Fem1c
fem-1 homolog C
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FEM1C mRNA
CTD
PMID:19191707
NCBI chr18:39,232,900...39,258,692
Ensembl chr18:39,232,900...39,258,692
G
Fen1
flap structure-specific endonuclease 1
increases expression decreases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FEN1 mRNA 4-hydroxy-2-nonenal results in decreased expression of FEN1 mRNA
CTD
PMID:19191707
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
G
Fgfr1
Fibroblast growth factor receptor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA
CTD
PMID:12419474
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
G
Fgr
FGR proto-oncogene, Src family tyrosine kinase
increases expression decreases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FGR mRNA 4-hydroxy-2-nonenal results in decreased expression of FGR mRNA
CTD
PMID:19191707
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
G
Fkbp14
FKBP prolyl isomerase 14
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FKBP14 mRNA
CTD
PMID:19191707
NCBI chr 4:83,705,531...83,721,515
Ensembl chr 4:83,705,652...83,721,528
G
Fkbpl
FKBP prolyl isomerase like
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of FKBPL mRNA
CTD
PMID:19191707
NCBI chr20:4,099,845...4,101,315
Ensembl chr20:4,099,806...4,101,368
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression multiple interactions
ISO
4-hydroxy-2-nonenal results in decreased expression of FOS mRNA 4-hydroxy-2-nonenal results in decreased expression of FOS protein resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of FOS protein]
CTD
PMID:12419474 PMID:16322078
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
multiple interactions
EXP
FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]
CTD
PMID:9890986
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
G
Foxm1
forkhead box M1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FOXM1 mRNA
CTD
PMID:19191707
NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
G
Foxo3
forkhead box O3
multiple interactions
ISO
FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]]
CTD
PMID:24633890
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Foxp1
forkhead box P1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FOXP1 mRNA
CTD
PMID:19191707
NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
G
Fubp1
far upstream element binding protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of FUBP1 mRNA
CTD
PMID:12419474
NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
G
Fxn
frataxin
multiple interactions
ISO
4-hydroxy-2-nonenal affects the reaction [Ethanol affects the expression of FXN protein]
CTD
PMID:33017621
NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
G
G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of G6PDX mRNA
CTD
PMID:19191707
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gabarapl1
GABA type A receptor associated protein like 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GABARAPL1 mRNA
CTD
PMID:19191707
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression multiple interactions
ISO EXP
4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]
CTD
PMID:19191707 PMID:24291486
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gak
cyclin G associated kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GAK mRNA
CTD
PMID:12419474
NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
multiple interactions
ISO
[Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]
CTD
PMID:20889679 PMID:23696560
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
G
Gata3
GATA binding protein 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GATA3 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
G
Gatad2b
GATA zinc finger domain containing 2B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GATAD2B mRNA
CTD
PMID:19191707
NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542
G
Gatb
glutamyl-tRNA amidotransferase subunit B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GATB mRNA
CTD
PMID:19191707
NCBI chr 2:170,930,547...171,017,133
Ensembl chr 2:170,930,542...171,016,695
G
Gbp1
guanylate binding protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GBP1 mRNA
CTD
PMID:19191707
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
G
Gbp4
guanylate binding protein 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GBP3 mRNA
CTD
PMID:19191707
NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
G
Gbp5
guanylate binding protein 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GBP5 mRNA
CTD
PMID:19191707
NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression multiple interactions
ISO EXP
4-hydroxy-2-nonenal results in increased expression of GCLC mRNA 4-hydroxy-2-nonenal results in increased expression of GCLC protein NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]
CTD
PMID:19191707 PMID:24291486
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GCLM mRNA
CTD
PMID:19191707
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gen1
GEN1 Holliday junction 5' flap endonuclease
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GEN1 mRNA
CTD
PMID:19191707
NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
G
Ggnbp1
gametogenetin binding protein 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GGNBP1 mRNA
CTD
PMID:19191707
NCBI chr20:5,109,849...5,116,185
Ensembl chr20:5,099,311...5,116,183
G
Gna13
G protein subunit alpha 13
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GNA13 mRNA
CTD
PMID:19191707
NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
G
Gnaq
G protein subunit alpha q
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA
CTD
PMID:19191707
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
G
Gnas
GNAS complex locus
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GNAS mRNA
CTD
PMID:12419474
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnat3
G protein subunit alpha transducin 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GNAT3 mRNA
CTD
PMID:19191707
NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283
G
Gnb1
G protein subunit beta 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GNB1 mRNA
CTD
PMID:12419474
NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
G
Gnb2
G protein subunit beta 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GNB2 mRNA
CTD
PMID:12419474
NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019
G
Got2
glutamic-oxaloacetic transaminase 2
multiple interactions
ISO
Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein]
CTD
PMID:20889679
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Gpr183
G protein-coupled receptor 183
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GPR183 mRNA
CTD
PMID:19191707
NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
G
Gpx1
glutathione peroxidase 1
increases abundance
ISO
GPX1 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal
CTD
PMID:24296279
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx2
glutathione peroxidase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GPX2 mRNA
CTD
PMID:12419474
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gsk3b
glycogen synthase kinase 3 beta
decreases expression decreases phosphorylation
ISO
4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNA 4-hydroxy-2-nonenal results in decreased phosphorylation of GSK3B protein
CTD
PMID:12419474 PMID:24825450
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsn
gelsolin
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GSN mRNA
CTD
PMID:19191707
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
G
Gsr
glutathione-disulfide reductase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GSR mRNA
CTD
PMID:19191707
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gss
glutathione synthetase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GSS mRNA
CTD
PMID:19191707
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
G
Gsta1
glutathione S-transferase alpha 1
decreases response to substance increases expression affects metabolic processing multiple interactions
ISO EXP
GSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog [GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
CTD
PMID:9799558 PMID:11256969 PMID:15829614
NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
G
Gsta3
glutathione S-transferase alpha 3
multiple interactions
EXP
[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
CTD
PMID:11256969
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
G
Gsta4
glutathione S-transferase alpha 4
multiple interactions affects metabolic processing increases expression
ISO EXP
GSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal; GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog 4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA; 4-hydroxy-2-nonenal results in increased expression of GSTA4 protein
CTD
PMID:2619714 PMID:7878679 PMID:8142470 PMID:8203886 PMID:9461507 PMID:9799558 PMID:10514034 PMID:11162605 PMID:11256969 PMID:11302754 PMID:11488593 PMID:12600725 PMID:15829614 PMID:16005854 More...
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
G
Gsta5
glutathione S-transferase alpha 5
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA
CTD
PMID:19191707
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
G
Gstm1
glutathione S-transferase mu 1
multiple interactions affects metabolic processing
ISO EXP
[GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; [GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal GSTM1 protein affects the metabolism of 4-hydroxy-2-nonenal analog [GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
CTD
PMID:11256969 PMID:21925487
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
decreases response to substance multiple interactions affects metabolic processing
ISO EXP
GSTM2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal [GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog GSTM2 protein affects the metabolism of 4-hydroxy-2-nonenal analog
CTD
PMID:11256969 PMID:15829614
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstp1
glutathione S-transferase pi 1
multiple interactions decreases response to substance increases expression affects binding decreases expression
ISO EXP
4-hydroxy-2-nonenal binds to and results in decreased activity of GSTP1 protein GSTP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased expression of GSTP1 protein 4-hydroxy-2-nonenal analog binds to GSTP1 4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein] 4-hydroxy-2-nonenal results in increased expression of GSTP1 mRNA
CTD
PMID:9463521 PMID:11600134 PMID:15829614 PMID:18232660 PMID:19191707 PMID:20570720 More...
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gtf2b
general transcription factor IIB
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of GTF2B mRNA
CTD
PMID:12419474
NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
G
H2ax
H2A.X variant histone
multiple interactions increases expression increases phosphorylation
ISO
POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] 4-hydroxy-2-nonenal results in increased expression of H2AX protein [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein
CTD
PMID:22331492 PMID:34503147
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
decreases activity
ISO
4-hydroxy-2-nonenal results in decreased activity of H6PD protein
CTD
PMID:20211231
NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
G
Haspin
histone H3 associated protein kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HASPIN mRNA
CTD
PMID:19191707
NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512
G
Hbegf
heparin-binding EGF-like growth factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HBEGF mRNA
CTD
PMID:12419474
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
G
Hbp1
HMG-box transcription factor 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HBP1 mRNA
CTD
PMID:19191707
NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
G
Hck
HCK proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HCK mRNA
CTD
PMID:19191707
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
G
Hdc
histidine decarboxylase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HDC mRNA
CTD
PMID:19191707
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Hells
helicase, lymphoid specific
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HELLS mRNA
CTD
PMID:19191707
NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
G
Herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HERC3 mRNA
CTD
PMID:19191707
NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
G
Herc6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HERC5 mRNA
CTD
PMID:19191707
NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
G
Hgf
hepatocyte growth factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HGF mRNA
CTD
PMID:12419474
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Hint1
histidine triad nucleotide binding protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNA
CTD
PMID:12419474
NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
G
Hivep2
HIVEP zinc finger 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
G
Hivep3
HIVEP zinc finger 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HIVEP3 mRNA
CTD
PMID:19191707
NCBI chr 5:133,325,327...133,727,797
Ensembl chr 5:133,658,052...133,727,795
G
Hlx
H2.0-like homeobox
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HLX mRNA
CTD
PMID:19191707
NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
G
Hmga1
high mobility group AT-hook 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HMGA1 mRNA
CTD
PMID:12419474
NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
G
Hmga2
high mobility group AT-hook 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HMGA2 mRNA
CTD
PMID:19191707
NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO EXP
4-hydroxy-2-nonenal analog results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA; 4-hydroxy-2-nonenal results in increased expression of HMOX1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; methyl-beta-cyclodextrin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein] 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
CTD
PMID:18232660 PMID:19191707 PMID:20638469 PMID:23845594 PMID:24291486 PMID:24423726 PMID:30849339 More...
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnf4a
hepatocyte nuclear factor 4, alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HNF4A mRNA
CTD
PMID:12419474
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HPRT1 mRNA
CTD
PMID:19191707
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
G
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HSD17B11 mRNA
CTD
PMID:19191707
NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
affects binding
EXP ISO
4-hydroxy-2-nonenal binds to HSP90AA1 protein 4-hydroxy-2-nonenal analog binds to HSP90AA1
CTD
PMID:18232660 PMID:21749116
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
affects binding
EXP
4-hydroxy-2-nonenal binds to HSP90AB1 protein
CTD
PMID:21749116
NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
affects binding
ISO
4-hydroxy-2-nonenal analog binds to HSPA1A
CTD
PMID:18232660
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1b
heat shock protein family A (Hsp70) member 1B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HSPA1B mRNA
CTD
PMID:19191707
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
affects binding
ISO
4-hydroxy-2-nonenal analog binds to HSPA1L
CTD
PMID:18232660
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Hspa2
heat shock protein family A (Hsp70) member 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HSPA2 mRNA
CTD
PMID:12419474
NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
G
Hspa4l
heat shock protein family A (Hsp70) member 4 like
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HSPA4L mRNA
CTD
PMID:19191707
NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
G
Hspa5
heat shock protein family A (Hsp70) member 5
affects binding multiple interactions increases expression
ISO EXP
4-hydroxy-2-nonenal analog binds to HSPA5 Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA] 4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA; 4-hydroxy-2-nonenal results in increased expression of HSPA5 protein
CTD
PMID:18232660 PMID:24291486
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Hspa9
heat shock protein family A (Hsp70) member 9
affects binding
ISO
4-hydroxy-2-nonenal analog binds to HSPA9
CTD
PMID:18232660
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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Hspd1
heat shock protein family D (Hsp60) member 1
affects binding
ISO
4-hydroxy-2-nonenal analog binds to HSPD1
CTD
PMID:18232660
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
G
Hsph1
heat shock protein family H (Hsp110) member 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HSPH1 mRNA
CTD
PMID:19191707
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
G
Htatip2
HIV-1 Tat interactive protein 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of HTATIP2 mRNA
CTD
PMID:19191707
NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
G
Hus1
HUS1 checkpoint clamp component
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of HUS1 mRNA
CTD
PMID:19191707
NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
G
Icam1
intercellular adhesion molecule 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ICAM1 mRNA
CTD
PMID:19191707
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Id1
inhibitor of DNA binding 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ID1 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
G
Idh1
isocitrate dehydrogenase (NADP(+)) 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of IDH1 mRNA
CTD
PMID:19191707
NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
G
Ier3
immediate early response 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IER3 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
G
Ifi44l
interferon-induced protein 44-like
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IFI44L mRNA
CTD
PMID:19191707
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
G
Ifih1
interferon induced with helicase C domain 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IFIH1 mRNA
CTD
PMID:19191707
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
G
Ifit2
interferon-induced protein with tetratricopeptide repeats 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IFIT2 mRNA
CTD
PMID:19191707
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
G
Ifit3
interferon-induced protein with tetratricopeptide repeats 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IFIT3 mRNA
CTD
PMID:19191707
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
G
Ifitm2
interferon induced transmembrane protein 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IFITM2 mRNA
CTD
PMID:19191707
NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
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Ifnb1
interferon beta 1
multiple interactions
ISO
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein]
CTD
PMID:19627980
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ifng
interferon gamma
multiple interactions
ISO
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IFNG protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]
CTD
PMID:18267128 PMID:33007382
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Igf1
insulin-like growth factor 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of IGF1 mRNA
CTD
PMID:19191707
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf1r
insulin-like growth factor 1 receptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IGF1R mRNA
CTD
PMID:12419474
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
G
Ikbke
inhibitor of nuclear factor kappa B kinase subunit epsilon
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of IKBKE mRNA
CTD
PMID:19191707
NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
G
Ikzf1
IKAROS family zinc finger 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IKZF1 mRNA
CTD
PMID:19191707
NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
G
Il10
interleukin 10
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL10 mRNA
CTD
PMID:19191707
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il10ra
interleukin 10 receptor subunit alpha
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of IL10RA mRNA
CTD
PMID:19191707
NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
G
Il12rb1
interleukin 12 receptor subunit beta 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL12RB1 mRNA
CTD
PMID:12419474
NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
G
Il13ra1
interleukin 13 receptor subunit alpha 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL13RA1 mRNA
CTD
PMID:19191707
NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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Il17a
interleukin 17A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL17A mRNA
CTD
PMID:12419474
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
G
Il18
interleukin 18
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il18rap
interleukin 18 receptor accessory protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL18RAP mRNA
CTD
PMID:19191707
NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
G
Il1a
interleukin 1 alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL1A mRNA
CTD
PMID:19191707
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL1B mRNA
CTD
PMID:19191707
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rl1
interleukin 1 receptor-like 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL1RL1 mRNA
CTD
PMID:19191707
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
G
Il1rn
interleukin 1 receptor antagonist
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL1RN mRNA
CTD
PMID:19191707
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
G
Il2
interleukin 2
multiple interactions
ISO
[Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IL2 protein
CTD
PMID:18267128
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il27
interleukin 27
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL27 mRNA
CTD
PMID:19191707
NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
G
Il3
interleukin 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL3 mRNA
CTD
PMID:12419474
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
G
Il36a
interleukin 36, alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL36A mRNA
CTD
PMID:19191707
NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400
G
Il4r
interleukin 4 receptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL4RA mRNA
CTD
PMID:19191707
NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
G
Il6
interleukin 6
decreases expression multiple interactions
ISO
4-hydroxy-2-nonenal results in decreased expression of IL6 mRNA [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]
CTD
PMID:19191707 PMID:33007382
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL6R mRNA
CTD
PMID:12419474
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
G
Il6st
interleukin 6 cytokine family signal transducer
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
G
Il7r
interleukin 7 receptor
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL7R mRNA 4-hydroxy-2-nonenal results in increased expression of IL7R mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
G
Il9
interleukin 9
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IL9 mRNA
CTD
PMID:12419474
NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895
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Impact
impact RWD domain protein
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IMPACT mRNA 4-hydroxy-2-nonenal results in increased expression of IMPACT mRNA
CTD
PMID:19191707
NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569
G
Inppl1
inositol polyphosphate phosphatase-like 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of INPPL1 mRNA
CTD
PMID:19191707
NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
G
Insig2
insulin induced gene 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of INSIG2 mRNA
CTD
PMID:19191707
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
G
Irak3
interleukin-1 receptor-associated kinase 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IRAK3 mRNA
CTD
PMID:19191707
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
G
Irf3
interferon regulatory factor 3
multiple interactions
ISO
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]
CTD
PMID:19627980
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
G
Irf7
interferon regulatory factor 7
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IRF7 mRNA
CTD
PMID:19191707
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
G
Irf8
interferon regulatory factor 8
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IRF8 mRNA
CTD
PMID:19191707
NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
G
Irgm
immunity-related GTPase M
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IRGM mRNA
CTD
PMID:19191707
NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
G
Isg15
ISG15 ubiquitin-like modifier
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ISG15 mRNA
CTD
PMID:19191707
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
G
Isg20
interferon stimulated exonuclease gene 20
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ISG20 mRNA
CTD
PMID:19191707
NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
G
Itga5
integrin subunit alpha 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNA
CTD
PMID:12419474
NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
G
Itga6
integrin subunit alpha 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITGA6 mRNA
CTD
PMID:12419474
NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
G
Itga7
integrin subunit alpha 7
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITGA7 mRNA
CTD
PMID:12419474
NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450
G
Itgal
integrin subunit alpha L
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITGAL mRNA
CTD
PMID:19191707
NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
G
Itgam
integrin subunit alpha M
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITGAM mRNA
CTD
PMID:19191707
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
G
Itgb6
integrin subunit beta 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITGB6 mRNA
CTD
PMID:12419474
NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
G
Itsn1
intersectin 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ITSN1 mRNA
CTD
PMID:12419474
NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645
G
Jak2
Janus kinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of JAK2 mRNA
CTD
PMID:19191707
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
G
Jdp2
Jun dimerization protein 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of JDP2 mRNA
CTD
PMID:19191707
NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression multiple interactions increases phosphorylation affects response to substance
ISO EXP
4-hydroxy-2-nonenal results in decreased expression of JUN mRNA 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein] JUN protein affects the susceptibility to 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein]
CTD
PMID:9890986 PMID:11488593 PMID:12419474 PMID:16322078 PMID:16337876 PMID:17263905 More...
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]
CTD
PMID:9890986
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Jund
JunD proto-oncogene, AP-1 transcription factor subunit
decreases expression multiple interactions
ISO EXP
4-hydroxy-2-nonenal results in decreased expression of JUND mRNA 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]
CTD
PMID:9890986 PMID:12419474
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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Kat8
lysine acetyltransferase 8
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of KAT8 mRNA
CTD
PMID:19191707
NCBI chr 1:182,524,355...182,536,638
Ensembl chr 1:182,515,327...182,536,633
G
Kdm6b
lysine demethylase 6B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of KDM6B mRNA
CTD
PMID:19191707
NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
G
Kif11
kinesin family member 11
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of KIF11 mRNA
CTD
PMID:19191707
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
G
Kif20b
kinesin family member 20B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of KIF20B mRNA
CTD
PMID:19191707
NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
G
Kitlg
KIT ligand
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of KITL mRNA
CTD
PMID:19191707
NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
G
Klf7
KLF transcription factor 7
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of KLF7 mRNA
CTD
PMID:19191707
NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
G
Klhl6
kelch-like family member 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of KLHL6 mRNA
CTD
PMID:19191707
NCBI chr11:80,970,917...81,010,593
Ensembl chr11:80,970,917...81,009,677
G
Kpna2
karyopherin subunit alpha 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of KPNA2 mRNA
CTD
PMID:19191707
NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
G
Lamp1
lysosomal-associated membrane protein 1
increases expression multiple interactions
ISO
4-hydroxy-2-nonenal results in increased expression of LAMP1 mRNA; 4-hydroxy-2-nonenal results in increased expression of LAMP1 protein Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]
CTD
PMID:35550146
NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
G
Lat
linker for activation of T cells
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LAT mRNA
CTD
PMID:12419474
NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
G
Lcat
lecithin cholesterol acyltransferase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LCAT mRNA
CTD
PMID:12419474
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Lck
LCK proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LCK mRNA
CTD
PMID:12419474
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
G
Lif
LIF, interleukin 6 family cytokine
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LIF mRNA
CTD
PMID:19191707
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
G
Lipa
lipase A, lysosomal acid type
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of LIPA mRNA
CTD
PMID:19191707
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
G
Lipg
lipase G, endothelial type
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LIPG mRNA
CTD
PMID:19191707
NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
G
Lpar1
lysophosphatidic acid receptor 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA
CTD
PMID:19191707
NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
G
Lpin1
lipin 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of LPIN1 mRNA
CTD
PMID:19191707
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
G
Lrrc59
leucine rich repeat containing 59
affects binding
ISO
LRRC59 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533
G
Lrrfip2
LRR binding FLII interacting protein 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of LRRFIP2 mRNA
CTD
PMID:19191707
NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255
G
Ltb
lymphotoxin beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LTB mRNA
CTD
PMID:19191707
NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
G
Ly6e
lymphocyte antigen 6 family member E
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LY6E mRNA
CTD
PMID:19191707
NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
G
Ly96
lymphocyte antigen 96
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of LY96 mRNA
CTD
PMID:19191707
NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
G
Lyn
LYN proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of LYN mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
G
Maf1
MAF1 homolog, negative regulator of RNA polymerase III
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MAF1 mRNA
CTD
PMID:19191707
NCBI chr 7:108,075,173...108,078,252
Ensembl chr 7:108,075,189...108,078,249
G
Mafb
MAF bZIP transcription factor B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MAFB mRNA
CTD
PMID:19191707
NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
G
Mafg
MAF bZIP transcription factor G
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MAFG mRNA
CTD
PMID:19191707
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MAP1LC3B mRNA
CTD
PMID:19191707
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Map2k5
mitogen activated protein kinase kinase 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MAP2K5 mRNA
CTD
PMID:12419474
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
G
Map3k20
mitogen-activated protein kinase kinase kinase 20
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MAP3K20 mRNA
CTD
PMID:19191707
NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
G
Mapk1
mitogen activated protein kinase 1
decreases activity multiple interactions increases phosphorylation
ISO EXP
4-hydroxy-2-nonenal results in decreased activity of MAPK1 protein 4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein] 4-hydroxy-2-nonenal results in increased phosphorylation of MAPK1 protein 4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK1 protein
CTD
PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk14
mitogen activated protein kinase 14
multiple interactions increases expression
ISO
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; Acetylcysteine inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein] 4-hydroxy-2-nonenal results in increased expression of MAPK14 mRNA 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]
CTD
PMID:12684028 PMID:16322078 PMID:19191707
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Mapk3
mitogen activated protein kinase 3
decreases activity multiple interactions increases phosphorylation
ISO EXP
4-hydroxy-2-nonenal results in decreased activity of MAPK3 protein 4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein] 4-hydroxy-2-nonenal results in increased phosphorylation of MAPK3 protein 4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK3 protein
CTD
PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
increases activity increases phosphorylation affects response to substance multiple interactions
ISO
4-hydroxy-2-nonenal results in increased activity of MAPK8 protein 4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein MAPK8 protein affects the susceptibility to 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; GSTA4 protein inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein] 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD
PMID:11488593 PMID:12684028 PMID:15064094 PMID:16322078 PMID:17263905 PMID:24825450 More...
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
increases phosphorylation
ISO
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK9 protein
CTD
PMID:24825450
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
G
Marcksl1
MARCKS-like 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MARCKSL1 mRNA
CTD
PMID:12419474
NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817
G
Mark3
microtubule affinity regulating kinase 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MARK3 mRNA
CTD
PMID:12419474
NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647
G
Mcm4
minichromosome maintenance complex component 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MCM4 mRNA
CTD
PMID:12419474
NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
G
Mcm6
minichromosome maintenance complex component 6
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MCM6 mRNA
CTD
PMID:19191707
NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
G
Metap1d
methionyl aminopeptidase type 1D (mitochondrial)
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of METAP1D mRNA
CTD
PMID:19191707
NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981
G
Mettl14
methyltransferase 14, N6-adenosine-methyltransferase subunit
multiple interactions
ISO
METTL14 protein promotes the reaction [Doxorubicin results in increased abundance of 4-hydroxy-2-nonenal]
CTD
PMID:34648132
NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821
G
Mitf
melanocyte inducing transcription factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MITF mRNA
CTD
PMID:23489423
NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
G
Mki67
marker of proliferation Ki-67
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MKI67 mRNA
CTD
PMID:19191707
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mknk1
MAPK interacting serine/threonine kinase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MKNK1 mRNA
CTD
PMID:19191707
NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
G
Mlh1
mutL homolog 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MLH1 mRNA
CTD
PMID:12419474
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
G
Mmp1
matrix metallopeptidase 1
increases activity increases expression
ISO
4-hydroxy-2-nonenal results in increased activity of MMP1 protein 4-hydroxy-2-nonenal results in increased expression of MMP1 mRNA
CTD
PMID:14672615
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
G
Mmp2
matrix metallopeptidase 2
increases activity increases expression multiple interactions
ISO EXP
4-hydroxy-2-nonenal results in increased activity of MMP2 protein 4-hydroxy-2-nonenal results in increased expression of MMP2 mRNA 1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 4-hydroxy-2-nonenal results in increased expression of and results in increased secretion of and results in increased activity of MMP2 protein; AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]
CTD
PMID:14672615 PMID:18805481
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
decreases expression increases activity multiple interactions increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MMP9 mRNA 4-hydroxy-2-nonenal results in increased activity of MMP9 protein ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; U 75302 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein] 4-hydroxy-2-nonenal results in increased expression of MMP9 mRNA; 4-hydroxy-2-nonenal results in increased expression of MMP9 protein
CTD
PMID:19191707 PMID:19837106
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mnda
myeloid cell nuclear differentiation antigen
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of IFI16 mRNA; 4-hydroxy-2-nonenal results in decreased expression of IFI204 mRNA 4-hydroxy-2-nonenal results in decreased expression of MNDA mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201
G
Mocos
molybdenum cofactor sulfurase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MOCOS mRNA
CTD
PMID:19191707
NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
G
Mov10
Mov10 RNA helicase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MOV10 mRNA
CTD
PMID:19191707
NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
G
Ms4a6a
membrane spanning 4-domains A6A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MS4A6C mRNA
CTD
PMID:19191707
NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758
G
Msh5
mutS homolog 5
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MSH5 mRNA
CTD
PMID:19191707
NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336
G
Mt2A
metallothionein 2A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MT2 mRNA
CTD
PMID:19191707
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
G
Mthfs
methenyltetrahydrofolate synthetase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MTHFS mRNA
CTD
PMID:19191707
NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
G
Mtmr10
myotubularin related protein 10
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MTMR10 mRNA
CTD
PMID:19191707
NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
G
Mtor
mechanistic target of rapamycin kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MTOR mRNA
CTD
PMID:12419474
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Mtss1
MTSS I-BAR domain containing 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MTSS1 mRNA
CTD
PMID:19191707
NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
G
Mutyh
mutY DNA glycosylase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of MUTYH mRNA
CTD
PMID:19191707
NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146
G
Mx1
MX dynamin like GTPase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MX1 mRNA
CTD
PMID:19191707
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
G
Mxd1
max dimerization protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MXD1 mRNA
CTD
PMID:19191707
NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751
G
Mybl2
MYB proto-oncogene like 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MYBL2 mRNA
CTD
PMID:12419474
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MYC mRNA
CTD
PMID:12419474
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Mylk
myosin light chain kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of MYLK mRNA
CTD
PMID:12419474
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
G
Nab2
Ngfi-A binding protein 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NAB2 mRNA
CTD
PMID:19191707
NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
G
Napb
NSF attachment protein beta
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NAPB mRNA
CTD
PMID:19191707
NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345
G
Nbn
nibrin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NBN mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
G
Nck1
NCK adaptor protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NCK1 mRNA
CTD
PMID:12419474
NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
G
Ndc80
NDC80 kinetochore complex component
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NDC80 mRNA
CTD
PMID:19191707
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
G
Nectin1
nectin cell adhesion molecule 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NECTIN1 mRNA
CTD
PMID:12419474
NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787
G
Neil3
nei-like DNA glycosylase 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NEIL3 mRNA
CTD
PMID:19191707
NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527
G
Nek2
NIMA-related kinase 2
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NEK2 mRNA 4-hydroxy-2-nonenal results in increased expression of NEK2 mRNA
CTD
PMID:19191707
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
G
Nek3
NIMA-related kinase 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NEK3 mRNA
CTD
PMID:19191707
NCBI chr16:69,867,020...69,892,477
Ensembl chr16:69,867,047...69,892,508
G
Nek6
NIMA-related kinase 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NEK6 mRNA
CTD
PMID:19191707
NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
G
Neo1
neogenin 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NEO1 mRNA
CTD
PMID:12419474
NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348
G
Neu1
neuraminidase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NEU1 mRNA
CTD
PMID:35550146
NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745
G
Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NF2 mRNA
CTD
PMID:12419474
NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
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Nfam1
NFAT activating protein with ITAM motif 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NFAM1 mRNA
CTD
PMID:19191707
NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442
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Nfatc1
nuclear factor of activated T-cells 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NFATC1 mRNA
CTD
PMID:12419474
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nfe2l1
NFE2 like bZIP transcription factor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NFE2L1 mRNA
CTD
PMID:12419474
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
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Nfe2l2
NFE2 like bZIP transcription factor 2
decreases activity multiple interactions affects response to substance affects localization increases expression
ISO EXP
4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal] 4-hydroxy-2-nonenal affects the localization of NFE2L2 protein 4-hydroxy-2-nonenal affects the localization of and results in increased activity of NFE2L2 protein; [GSTA4 protein mutant form results in decreased glutathionylation of 4-hydroxy-2-nonenal] which results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein] 4-hydroxy-2-nonenal results in increased expression of NFE2L2 protein NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]
CTD
PMID:16322078 PMID:19880816 PMID:24291486 PMID:24423726 PMID:24633890 PMID:29108775 PMID:30849339 More...
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfic
nuclear factor I/C
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NFIC mRNA
CTD
PMID:19191707
NCBI chr 7:8,278,210...8,309,936
Ensembl chr 7:8,253,361...8,309,936
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Nfix
nuclear factor I X
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NFIX mRNA
CTD
PMID:12419474
NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
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Nfkb1
nuclear factor kappa B subunit 1
decreases expression multiple interactions
ISO EXP
4-hydroxy-2-nonenal results in decreased expression of NFKB1 mRNA 4-hydroxy-2-nonenal results in decreased activity of [NFKB1 protein binds to NFKB1 protein]; 4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]
CTD
PMID:11146106 PMID:12419474 PMID:19191707
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions increases expression
ISO
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] 4-hydroxy-2-nonenal results in increased expression of NFKBIA mRNA
CTD
PMID:19191707 PMID:19627980
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nfkbie
NFKB inhibitor epsilon
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NFKBIE mRNA
CTD
PMID:19191707
NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
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Nfkbiz
NFKB inhibitor zeta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NFKBIZ mRNA
CTD
PMID:19191707
NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
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Nfrkb
nuclear factor related to kappa B binding protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NFRKB mRNA
CTD
PMID:12419474
NCBI chr 8:29,831,802...29,863,360
Ensembl chr 8:29,831,812...29,863,359
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Nfx1
nuclear transcription factor, X-box binding 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NFX1 mRNA
CTD
PMID:12419474
NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912
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Nkiras1
NFKB inhibitor interacting Ras-like 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NKIRAS1 mRNA
CTD
PMID:19191707
NCBI chr15:7,493,531...7,503,758
Ensembl chr15:7,493,531...7,503,854
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Nlrc4
NLR family, CARD domain containing 4
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NLRC4 mRNA
CTD
PMID:19191707
NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
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Nlrp10
NLR family, pyrin domain containing 10
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NLRP10 mRNA
CTD
PMID:19191707
NCBI chr 1:162,922,806...162,930,363
Ensembl chr 1:162,922,806...162,930,363
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Nlrp3
NLR family, pyrin domain containing 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NLRP3 mRNA
CTD
PMID:19191707
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nmb
neuromedin B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NMB mRNA
CTD
PMID:12419474
NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
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Nme2
NME/NM23 nucleoside diphosphate kinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NME2 mRNA
CTD
PMID:12419474
NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
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Nos2
nitric oxide synthase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NOS2 protein
CTD
PMID:20940037
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Notch1
notch receptor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NOTCH1 mRNA
CTD
PMID:19191707
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA 4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA; 4-hydroxy-2-nonenal results in increased expression of NQO1 protein
CTD
PMID:24423726 PMID:29108775 PMID:30849339
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NR1D1 mRNA
CTD
PMID:19191707
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr1d2
nuclear receptor subfamily 1, group D, member 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NR1D2 mRNA
CTD
PMID:19191707
NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NR1I3 mRNA
CTD
PMID:12419474
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr2f6
nuclear receptor subfamily 2, group F, member 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NR2F6 mRNA
CTD
PMID:12419474
NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NR3C1 mRNA
CTD
PMID:19191707
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NR4A1 mRNA
CTD
PMID:19191707
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nrp1
neuropilin 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NRP1 mRNA
CTD
PMID:19191707
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
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Nsl1
NSL1 component of MIS12 kinetochore complex
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NSL1 mRNA
CTD
PMID:19191707
NCBI chr13:102,649,050...102,674,059
Ensembl chr13:102,649,058...102,674,054
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Nuf2
NUF2 component of NDC80 kinetochore complex
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NUF2 mRNA
CTD
PMID:19191707
NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
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Nufip1
nuclear FMR1 interacting protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NUFIP1 mRNA
CTD
PMID:19191707
NCBI chr15:51,429,518...51,460,308
Ensembl chr15:51,429,549...51,460,310
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Nup210
nucleoporin 210
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NUP210 mRNA
CTD
PMID:19191707
NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874
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Nup85
nucleoporin 85
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of NUP85 mRNA
CTD
PMID:19191707
NCBI chr10:100,806,482...100,825,029
Ensembl chr10:100,806,437...100,825,043
G
Nusap1
nucleolar and spindle associated protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of NUSAP1 mRNA
CTD
PMID:19191707
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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Oas3
2'-5'-oligoadenylate synthetase 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of OAS3 mRNA
CTD
PMID:19191707
NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
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Olr1271
olfactory receptor 1271
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of OR8D1 mRNA; 4-hydroxy-2-nonenal results in increased expression of OR8D1B mRNA
CTD
PMID:19191707
NCBI chr 8:39,127,409...39,131,889
Ensembl chr 8:39,127,352...39,131,900
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Osm
oncostatin M
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of OSM mRNA
CTD
PMID:19191707
NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
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Otub1
OTU deubiquitinase, ubiquitin aldehyde binding 1
multiple interactions
ISO
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal
CTD
PMID:35234341
NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
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P2rx5
purinergic receptor P2X 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of P2RX5 mRNA
CTD
PMID:12419474
NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423
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P2ry2
purinergic receptor P2Y2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of P2RY2 mRNA
CTD
PMID:19191707
NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
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P4hb
prolyl 4-hydroxylase subunit beta
affects metabolic processing
EXP
4-hydroxy-2-nonenal affects the metabolism of P4HB protein
CTD
PMID:16097806
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
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Pa2g4
proliferation-associated 2G4
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PA2G4 mRNA
CTD
PMID:19191707
NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
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Paip1
poly(A) binding protein interacting protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PAIP1 mRNA
CTD
PMID:12419474
NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241
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Parp1
poly (ADP-ribose) polymerase 1
increases degradation
ISO
4-hydroxy-2-nonenal results in increased degradation of PARP1 protein
CTD
PMID:11488593
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Parp12
poly (ADP-ribose) polymerase family, member 12
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PARP12 mRNA
CTD
PMID:19191707
NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685
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Pbk
PDZ binding kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PBK mRNA
CTD
PMID:19191707
NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
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Pcgf5
polycomb group ring finger 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PCGF5 mRNA
CTD
PMID:19191707
NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315
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Pcna
proliferating cell nuclear antigen
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PCNA mRNA
CTD
PMID:19191707
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pcsk2
proprotein convertase subtilisin/kexin type 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PCSK2 mRNA
CTD
PMID:12419474
NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
G
Pcyox1
prenylcysteine oxidase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PCYOX1 mRNA
CTD
PMID:19191707
NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
G
Pdcd4
programmed cell death 4
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PDCD4 mRNA
CTD
PMID:19191707
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pdgfb
platelet derived growth factor subunit B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PDGFB mRNA
CTD
PMID:19191707
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Pdia3
protein disulfide isomerase family A, member 3
affects binding
ISO
4-hydroxy-2-nonenal analog binds to PDIA3
CTD
PMID:18232660
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
G
Pdss1
decaprenyl diphosphate synthase subunit 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PDSS1 mRNA
CTD
PMID:19191707
NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730
G
Pdyn
prodynorphin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PDYN mRNA
CTD
PMID:12419474
NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
G
Penk
proenkephalin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PENK mRNA
CTD
PMID:19191707
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
G
Per1
period circadian regulator 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PER1 mRNA
CTD
PMID:19191707
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
G
Pex7
peroxisomal biogenesis factor 7
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PEX7 mRNA
CTD
PMID:19191707
NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748
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Pgd
phosphogluconate dehydrogenase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PGD mRNA
CTD
PMID:19191707
NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
G
Pglyrp3
peptidoglycan recognition protein 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PGLYRP3 mRNA
CTD
PMID:19191707
NCBI chr 2:177,479,693...177,490,769
Ensembl chr 2:177,477,407...177,490,736 Ensembl chr 2:177,477,407...177,490,736
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Pgm2l1
phosphoglucomutase 2-like 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PGM2L1 mRNA
CTD
PMID:19191707
NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902
G
Pgs1
phosphatidylglycerophosphate synthase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PGS1 mRNA
CTD
PMID:19191707
NCBI chr10:103,214,635...103,250,254
Ensembl chr10:103,214,646...103,250,254
G
Phb1
prohibitin 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PHB1 mRNA
CTD
PMID:12419474
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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Phf11
PHD finger protein 11
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PHF11 mRNA
CTD
PMID:19191707
NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009
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Phf21a
PHD finger protein 21A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PHF21A mRNA
CTD
PMID:19191707
NCBI chr 3:78,158,760...78,331,903
Ensembl chr 3:78,194,549...78,331,865
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Phgdh
phosphoglycerate dehydrogenase
affects binding
ISO
PHGDH protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
G
Phlda1
pleckstrin homology-like domain, family A, member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PHLDA1 mRNA
CTD
PMID:19191707
NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
G
Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PIK3CB mRNA
CTD
PMID:19191707
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
G
Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PIK3CD mRNA
CTD
PMID:19191707
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
G
Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PIK3R2 mRNA
CTD
PMID:12419474
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
G
Pilra
paired immunoglobin-like type 2 receptor alpha
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PILRA mRNA
CTD
PMID:19191707
NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094
G
Pin1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
affects binding increases response to substance
ISO
4-hydroxy-2-nonenal binds to PIN1 protein PIN1 protein results in increased susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:23231502
NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
G
Pkm
pyruvate kinase M1/2
affects binding multiple interactions
ISO
4-hydroxy-2-nonenal analog binds to PKM protein 4-hydroxy-2-nonenal binds to and results in decreased activity of PKM protein; 4-hydroxy-2-nonenal promotes the reaction [PKM protein binds to PKM protein]
CTD
PMID:27978618
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
G
Pla2g7
phospholipase A2 group VII
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PLA2G7 mRNA
CTD
PMID:19191707
NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
G
Plagl2
PLAG1 like zinc finger 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PLAGL2 mRNA
CTD
PMID:19191707
NCBI chr 3:141,695,322...141,708,516
Ensembl chr 3:141,695,322...141,708,503
G
Pld2
phospholipase D2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PLD2 mRNA
CTD
PMID:19191707
NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
G
Plekhm1
pleckstrin homology and RUN domain containing M1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PLEKHM1 mRNA
CTD
PMID:19191707
NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
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Plekho1
pleckstrin homology domain containing O1
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PLEKHO1 mRNA 4-hydroxy-2-nonenal results in increased expression of PLEKHO1 mRNA
CTD
PMID:19191707
NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
G
Plk1
polo-like kinase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PLK1 mRNA
CTD
PMID:19191707
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
G
Plk2
polo-like kinase 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PLK2 mRNA
CTD
PMID:19191707
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
G
Polb
DNA polymerase beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of POLB mRNA
CTD
PMID:12419474
NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
G
Pold1
DNA polymerase delta 1, catalytic subunit
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of POLD1 mRNA
CTD
PMID:12419474
NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
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Pole
DNA polymerase epsilon, catalytic subunit
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of POLE mRNA
CTD
PMID:19191707
NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
G
Polh
DNA polymerase eta
multiple interactions affects response to substance
ISO
POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] POLH protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:22331492
NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
G
Polk
DNA polymerase kappa
multiple interactions
ISO
POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
CTD
PMID:22331492
NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
G
Poll
DNA polymerase lambda
affects response to substance multiple interactions
ISO
POLL protein affects the susceptibility to 4-hydroxy-2-nonenal POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
CTD
PMID:22331492
NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662
G
Polq
DNA polymerase theta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of POLQ mRNA
CTD
PMID:19191707
NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878
G
Pon1
paraoxonase 1
multiple interactions decreases activity
ISO
4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] 4-hydroxy-2-nonenal results in decreased activity of PON1 protein
CTD
PMID:15375178
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
G
Pou2f2
POU class 2 homeobox 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of POU2F2 mRNA
CTD
PMID:19191707
NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
G
Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PPARG protein
CTD
PMID:27417252
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppid
peptidylprolyl isomerase D
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PPID mRNA
CTD
PMID:19191707
NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221
G
Ppil1
peptidylprolyl isomerase like 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PPIL1 mRNA
CTD
PMID:19191707
NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
G
Ppp1ca
protein phosphatase 1 catalytic subunit alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PPP1CA mRNA
CTD
PMID:12419474
NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression multiple interactions
EXP
4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA]
CTD
PMID:24291486
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
G
Ppp1r15b
protein phosphatase 1, regulatory subunit 15B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PPP1R15B mRNA
CTD
PMID:19191707
NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737
G
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA
CTD
PMID:12419474
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
G
Prdm1
PR/SET domain 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PRDM1 mRNA
CTD
PMID:12419474
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
G
Prdx1
peroxiredoxin 1
affects binding increases expression
ISO
4-hydroxy-2-nonenal analog binds to PRDX1 4-hydroxy-2-nonenal results in increased expression of PRDX1 mRNA
CTD
PMID:18232660 PMID:19191707
NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
G
Prkdc
protein kinase, DNA-activated, catalytic subunit
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PRKDC mRNA
CTD
PMID:12419474
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
G
Procr
protein C receptor
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PROCR mRNA
CTD
PMID:19191707
NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
G
Psmb10
proteasome 20S subunit beta 10
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PSMB10 mRNA
CTD
PMID:19191707
NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
G
Psmc3ip
PSMC3 interacting protein
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PSMC3IP mRNA
CTD
PMID:19191707
NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
G
Psmd12
proteasome 26S subunit, non-ATPase 12
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PSMD12 mRNA
CTD
PMID:19191707
NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
G
Ptger4
prostaglandin E receptor 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PTGER4 mRNA
CTD
PMID:19191707
NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
G
Ptges
prostaglandin E synthase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PTGES mRNA
CTD
PMID:19191707
NCBI chr 3:14,177,892...14,189,236
G
Ptgr1
prostaglandin reductase 1
multiple interactions decreases response to substance
EXP
[PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal PTGR1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:11524419
NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
G
Ptk2
protein tyrosine kinase 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PTK2 mRNA
CTD
PMID:12419474
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
G
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PTPN1 mRNA
CTD
PMID:12419474
NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
G
Ptpra
protein tyrosine phosphatase, receptor type, A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of PTPRA mRNA
CTD
PMID:19191707
NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
G
Pxk
PX domain containing serine/threonine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of PXK mRNA
CTD
PMID:19191707
NCBI chr15:16,759,857...16,828,452
Ensembl chr15:16,759,862...16,828,444
G
Rab11a
RAB11a, member RAS oncogene family
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RAB11A mRNA
CTD
PMID:19191707
NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
G
Rabgef1
RAB guanine nucleotide exchange factor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RABGEF1 mRNA
CTD
PMID:19191707
NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
G
Rad23a
RAD23 homolog A, nucleotide excision repair protein
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RAD23A mRNA
CTD
PMID:19191707
NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
G
Rad51
RAD51 recombinase
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RAD51 mRNA 4-hydroxy-2-nonenal results in increased expression of RAD51 mRNA
CTD
PMID:19191707
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
G
Rad54l
RAD54 like
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RAD54L mRNA
CTD
PMID:19191707
NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
G
Raet1e
retinoic acid early transcript 1E
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RAET1E mRNA
CTD
PMID:19191707
NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RAF1 mRNA
CTD
PMID:19191707
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
G
Ralbp1
ralA binding protein 1
decreases response to substance
ISO
RALBP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:15950949
NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
G
Ralgds
ral guanine nucleotide dissociation stimulator
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RALGDS mRNA
CTD
PMID:12419474
NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059
G
Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RALGPS1 mRNA
CTD
PMID:19191707
NCBI chr 3:16,433,323...16,670,276
Ensembl chr 3:16,433,742...16,669,972
G
Rara
retinoic acid receptor, alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RARA mRNA
CTD
PMID:19191707
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
G
Rarb
retinoic acid receptor, beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RARB mRNA
CTD
PMID:12419474
NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
G
Rasgef1b
RasGEF domain family, member 1B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RASGEF1B mRNA
CTD
PMID:19191707
NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741
G
Rasgrp3
RAS guanyl releasing protein 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RASGRP3 mRNA
CTD
PMID:19191707
NCBI chr 6:19,895,361...19,993,945
Ensembl chr 6:19,895,390...19,958,578
G
Rassf2
Ras association domain family member 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RASSF2 mRNA
CTD
PMID:19191707
NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
G
Rassf8
Ras association domain family member 8
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RASSF8 mRNA
CTD
PMID:19191707
NCBI chr 4:178,716,110...178,798,042
Ensembl chr 4:178,719,992...178,796,690
G
Rb1
RB transcriptional corepressor 1
decreases phosphorylation multiple interactions
ISO
4-hydroxy-2-nonenal results in decreased phosphorylation of RB1 protein [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form
CTD
PMID:15607904 PMID:33007382
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
G
Rbl1
RB transcriptional corepressor like 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RBL1 mRNA
CTD
PMID:19191707
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
G
Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RBL2 mRNA
CTD
PMID:12419474
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
G
Rel
REL proto-oncogene, NF-kB subunit
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of REL mRNA
CTD
PMID:12419474
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]
CTD
PMID:11146106
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rev1
REV1, DNA directed polymerase
multiple interactions affects response to substance
ISO
REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] REV1 protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:22331492
NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576
G
Rev3l
REV3 like, DNA directed polymerase zeta catalytic subunit
multiple interactions affects response to substance
ISO
REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] REV3L protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD
PMID:22331492
NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
G
Rffl
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RFFL mRNA
CTD
PMID:19191707
NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434
G
Rgs1
regulator of G-protein signaling 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RGS1 mRNA
CTD
PMID:19191707
NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984
G
Rig1
RNA sensor RIG-1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RIGI mRNA
CTD
PMID:19191707
NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
G
Riok3
RIO kinase 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RIOK3 mRNA
CTD
PMID:19191707
NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343
G
Rit1
Ras-like without CAAX 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RIT1 mRNA
CTD
PMID:19191707
NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455
G
Rnd1
Rho family GTPase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RND1 mRNA
CTD
PMID:19191707
NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
G
Rnf128
ring finger protein 128
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RNF128 mRNA
CTD
PMID:19191707
NCBI chr X:103,183,643...103,298,431
Ensembl chr X:103,183,831...103,298,423
G
Rnf167
ring finger protein 167
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RNF167 mRNA
CTD
PMID:19191707
NCBI chr10:55,360,603...55,364,927
Ensembl chr10:55,360,543...55,364,927
G
Rnf19b
ring finger protein 19B
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RNF19B mRNA
CTD
PMID:19191707
NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380
G
Rpp38
ribonuclease P/MRP subunit p38
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RPP38 mRNA
CTD
PMID:19191707
NCBI chr17:74,914,066...74,917,742
Ensembl chr17:74,908,932...74,927,431
G
Rps6ka2
ribosomal protein S6 kinase A2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RPS6KA2 mRNA
CTD
PMID:12419474
NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
G
Rps6kb1
ribosomal protein S6 kinase B1
increases phosphorylation
EXP
4-hydroxy-2-nonenal results in increased phosphorylation of RPS6KB1 protein
CTD
PMID:19289642
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
G
Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RSAD2 mRNA
CTD
PMID:19191707
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
G
RT1-A2
RT1 class Ia, locus A2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of H2-T23 mRNA
CTD
PMID:19191707
NCBI chr20:4,870,939...4,910,183
G
RT1-CE16
RT1 class I, locus CE16
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of H2-Q1 mRNA
CTD
PMID:19191707
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
G
Rxra
retinoid X receptor alpha
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of RXRA mRNA
CTD
PMID:19191707
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
Rxrb
retinoid X receptor beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of RXRB mRNA
CTD
PMID:12419474
NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
G
S1pr2
sphingosine-1-phosphate receptor 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of S1PR2 mRNA
CTD
PMID:19191707
NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
G
Samhd1
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
affects binding
ISO
SAMHD1 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386
G
Samsn1
SAM domain, SH3 domain and nuclear localization signals, 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SAMSN1 mRNA
CTD
PMID:19191707
NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900
G
Sass6
SAS-6 centriolar assembly protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SASS6 mRNA
CTD
PMID:19191707
NCBI chr 2:204,546,660...204,578,930
Ensembl chr 2:204,546,660...204,578,927
G
Satb1
SATB homeobox 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SATB1 mRNA
CTD
PMID:12419474
NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251
G
Sbno2
strawberry notch homolog 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SBNO2 mRNA
CTD
PMID:19191707
NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
G
Scarb1
scavenger receptor class B, member 1
multiple interactions affects binding
ISO
Tobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein]
CTD
PMID:22442701
NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
G
Selenbp1
selenium binding protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SELENBP1 mRNA
CTD
PMID:12419474
NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594
G
Serbp1
Serpine1 mRNA binding protein 1
affects binding
ISO
SERBP1 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813
G
Serpinb5
serpin family B member 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SERPINB5 mRNA
CTD
PMID:12419474
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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Serpinb9
serpin family B member 9
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SERPINB9 mRNA
CTD
PMID:19191707
NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
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Serpini1
serpin family I member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SERPINI1 mRNA
CTD
PMID:12419474
NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
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Sesn2
sestrin 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SESN2 mRNA
CTD
PMID:19191707
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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Sgk1
serum/glucocorticoid regulated kinase 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SGK1 mRNA
CTD
PMID:19191707
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Sgo1
shugoshin 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SGO1 mRNA
CTD
PMID:19191707
NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805
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Sgo2
shugoshin 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SGO2 mRNA
CTD
PMID:19191707
NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229
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Sgpl1
sphingosine-1-phosphate lyase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SGPL1 mRNA
CTD
PMID:19191707
NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084
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Shoc2
SHOC2 leucine-rich repeat scaffold protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SHOC2 mRNA
CTD
PMID:12419474
NCBI chr 1:252,958,939...253,048,820
Ensembl chr 1:252,959,723...253,047,337
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Sirt1
sirtuin 1
multiple interactions
ISO
SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]
CTD
PMID:24633890
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Sirt3
sirtuin 3
multiple interactions
ISO
4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein
CTD
PMID:21449565
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Slc25a27
solute carrier family 25, member 27
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SLC25A27 mRNA
CTD
PMID:20385226
NCBI chr 9:17,306,898...17,333,942
Ensembl chr 9:17,307,023...17,332,731
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Slc7a11
solute carrier family 7 member 11
multiple interactions
ISO
[APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal [[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal
CTD
PMID:21967605 PMID:35234341
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Slc7a2
solute carrier family 7 member 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SLC7A2 mRNA
CTD
PMID:19191707
NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
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Smad1
SMAD family member 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SMAD1 mRNA
CTD
PMID:12419474
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Smc4
structural maintenance of chromosomes 4
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SMC4 mRNA
CTD
PMID:19191707
NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
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Snapc5
small nuclear RNA activating complex, polypeptide 5
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SNAPC5 mRNA
CTD
PMID:19191707
NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964
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Socs3
suppressor of cytokine signaling 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SOCS3 mRNA
CTD
PMID:19191707
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sod2
superoxide dismutase 2
affects binding increases abundance multiple interactions decreases abundance increases expression
ISO
4-hydroxy-2-nonenal binds to SOD2 protein SOD2 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal SOD2 protein inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased abundance of 4-hydroxy-2-nonenal] SOD2 protein results in decreased abundance of 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in increased expression of SOD2 mRNA
CTD
PMID:11507057 PMID:19191707 PMID:19374891 PMID:23199288
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sp100
SP100 nuclear antigen
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SP100 mRNA
CTD
PMID:19191707
NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034
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Sp110
SP110 nuclear body protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SP110 mRNA
CTD
PMID:19191707
NCBI chr 9:86,200,503...86,225,355
Ensembl chr 9:86,200,503...86,222,670
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Sp2
Sp2 transcription factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SP2 mRNA
CTD
PMID:12419474
NCBI chr10:81,940,580...81,970,040
Ensembl chr10:81,940,587...81,970,548
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Spa17
sperm autoantigenic protein 17
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SPA17 mRNA
CTD
PMID:19191707
NCBI chr 8:37,307,432...37,318,519
Ensembl chr 8:37,307,557...37,318,639
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Spag5
sperm associated antigen 5
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SPAG5 mRNA
CTD
PMID:19191707
NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745
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Spry1
sprouty RTK signaling antagonist 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SPRY1 mRNA
CTD
PMID:19191707
NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189
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Spry2
sprouty RTK signaling antagonist 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SPRY2 mRNA
CTD
PMID:12419474
NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009
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Sqstm1
sequestosome 1
increases expression multiple interactions
ISO
4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]
CTD
PMID:19191707 PMID:35550146
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SRC mRNA
CTD
PMID:19191707
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Srp9
signal recognition particle 9
affects binding
ISO
SRP9 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720
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Srpk2
SRSF protein kinase 2
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SRPK2 mRNA
CTD
PMID:19191707
NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990
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Srxn1
sulfiredoxin 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SRXN1 mRNA
CTD
PMID:19191707 PMID:22003191
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Ssbp3
single stranded DNA binding protein 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SSBP3 mRNA
CTD
PMID:19191707
NCBI chr 5:121,691,370...121,828,035
Ensembl chr 5:121,691,393...121,827,992
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Stat1
signal transducer and activator of transcription 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of STAT1 mRNA
CTD
PMID:19191707
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of STAT3 mRNA
CTD
PMID:19191707
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stat5a
signal transducer and activator of transcription 5A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of STAT5A mRNA
CTD
PMID:19191707
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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Stat6
signal transducer and activator of transcription 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of STAT6 mRNA
CTD
PMID:12419474
NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
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Stk11
serine/threonine kinase 11
decreases activity decreases expression multiple interactions affects binding
EXP
4-hydroxy-2-nonenal results in decreased activity of STK11 protein 4-hydroxy-2-nonenal results in decreased expression of STK11 protein; 4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form resveratrol inhibits the reaction [4-hydroxy-2-nonenal binds to STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form]
CTD
PMID:19289642
NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
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Stk17b
serine/threonine kinase 17b
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of STK17B mRNA
CTD
PMID:19191707
NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031
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Stk3
serine/threonine kinase 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of STK3 mRNA
CTD
PMID:19191707
NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
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Stmn1
stathmin 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of STMN1 mRNA
CTD
PMID:19191707
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Stradb
STE20 related adaptor beta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of STRADB mRNA
CTD
PMID:19191707
NCBI chr 9:60,414,182...60,433,084
Ensembl chr 9:60,414,182...60,433,084
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Suclg1
succinate-CoA ligase GDP/ADP-forming subunit alpha
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SUCLG1 mRNA
CTD
PMID:19191707
NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
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Sumo3
small ubiquitin-like modifier 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SUMO3 mRNA
CTD
PMID:19191707
NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877 Ensembl chr20:11,007,148...11,020,877
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Suv39h1
SUV39H1 histone lysine methyltransferase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SUV39H1 mRNA
CTD
PMID:19191707
NCBI chr X:14,421,028...14,433,993
Ensembl chr X:14,421,109...14,433,982
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Suv39h1-ps1
SUV39H1 histone lysine methyltransferase, pseudogene 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of SUV39H1 mRNA
CTD
PMID:19191707
NCBI chr X:141,792,589...141,795,257
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Syp
synaptophysin
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of SYP mRNA
CTD
PMID:12419474
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Tac1
tachykinin, precursor 1
increases secretion
EXP
4-hydroxy-2-nonenal results in increased secretion of TAC1 protein
CTD
PMID:17684094
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tacc3
transforming, acidic coiled-coil containing protein 3
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TACC3 mRNA 4-hydroxy-2-nonenal results in increased expression of TACC3 mRNA
CTD
PMID:19191707
NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
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Tada3
transcriptional adaptor 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TADA3 mRNA
CTD
PMID:12419474
NCBI chr 4:146,510,213...146,521,975
Ensembl chr 4:146,510,246...146,521,590
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Tank
TRAF family member-associated NFKB activator
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TANK mRNA
CTD
PMID:12419474
NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264
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Tbc1d12
TBC1 domain family, member 12
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TBC1D12 mRNA
CTD
PMID:19191707
NCBI chr 1:236,603,597...236,685,859
Ensembl chr 1:236,603,607...236,685,859
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Tbc1d31
TBC1 domain family, member 31
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TBC1D31 mRNA
CTD
PMID:19191707
NCBI chr 7:89,427,354...89,506,894
Ensembl chr 7:89,426,780...89,506,894
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Tbc1d8b
TBC1 domain family member 8B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TBC1D8B mRNA
CTD
PMID:19191707
NCBI chr X:103,319,181...103,407,137
Ensembl chr X:103,319,340...103,407,133
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Tbl1xr1
TBL1X/Y related 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TBL1XR1 mRNA
CTD
PMID:19191707
NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055
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Tcf3
transcription factor 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TCF3 mRNA
CTD
PMID:12419474
NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
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Terf1
telomeric repeat binding factor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TERF1 mRNA
CTD
PMID:12419474
NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
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Tfdp2
transcription factor Dp-2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TFDP2 mRNA
CTD
PMID:12419474
NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682
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Tfeb
transcription factor EB
multiple interactions affects response to substance affects localization
ISO
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; 4-hydroxy-2-nonenal results in decreased phosphorylation of and affects the localization of TFEB protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA] TFEB protein affects the susceptibility to 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal affects the localization of TFEB protein; 4-hydroxy-2-nonenal affects the localization of TFEB protein mutant form
CTD
PMID:35550146
NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TGFB1 mRNA
CTD
PMID:19191707
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfbr1
transforming growth factor, beta receptor 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TGFBR1 mRNA
CTD
PMID:19191707
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
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Thra
thyroid hormone receptor alpha
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of THRA mRNA
CTD
PMID:19191707
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression decreases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TIMP1 mRNA 4-hydroxy-2-nonenal results in decreased expression of TIMP1 mRNA
CTD
PMID:14672615 PMID:19191707
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TIPARP mRNA
CTD
PMID:19191707
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tjp1
tight junction protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TJP1 mRNA
CTD
PMID:12419474
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tlr4
toll-like receptor 4
multiple interactions decreases activity
ISO
4-hydroxy-2-nonenal inhibits the reaction [TLR4 protein binds to TLR4 protein] 4-hydroxy-2-nonenal results in decreased activity of TLR4 protein 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]
CTD
PMID:19627980
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein 4-hydroxy-2-nonenal results in increased expression of TNF mRNA
CTD
PMID:19191707 PMID:19627980 PMID:33007382
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip2
TNF alpha induced protein 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TNFAIP2 mRNA
CTD
PMID:12419474
NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
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Tnfaip3
TNF alpha induced protein 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TNFAIP3 mRNA
CTD
PMID:19191707
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tnfaip8
TNF alpha induced protein 8
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TNFAIP8 mRNA 4-hydroxy-2-nonenal results in increased expression of TNFAIP8 mRNA
CTD
PMID:19191707
NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
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Tnfrsf10b
TNF receptor superfamily member 10b
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TNFRSF10B mRNA
CTD
PMID:19191707
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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Tnfrsf1a
TNF receptor superfamily member 1A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TNFRSF1A mRNA
CTD
PMID:12419474
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Top1
DNA topoisomerase I
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TOP1 mRNA
CTD
PMID:12419474
NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
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Top2a
DNA topoisomerase II alpha
decreases expression increases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA 4-hydroxy-2-nonenal results in increased expression of TOP2A mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
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Tp53
tumor protein p53
increases expression increases mutagenesis affects abundance
ISO
4-hydroxy-2-nonenal results in increased expression of TP53 mRNA; 4-hydroxy-2-nonenal results in increased expression of TP53 protein 4-hydroxy-2-nonenal results in increased mutagenesis of TP53 gene TRP53 protein affects the abundance of 4-hydroxy-2-nonenal
CTD
PMID:11050162 PMID:15607904 PMID:22229939
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53bp1
tumor protein p53 binding protein 1
multiple interactions
ISO
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] affects the expression of TP53BP1 protein
CTD
PMID:34503147
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
G
Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TRP53INP1 mRNA
CTD
PMID:19191707
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
G
Tp63
tumor protein p63
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TP63 protein
CTD
PMID:15607904
NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
G
Tp73
tumor protein p73
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TP73 protein
CTD
PMID:15607904
NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
G
Tpi1
triosephosphate isomerase 1
affects binding
ISO
4-hydroxy-2-nonenal binds to TPI1 protein
CTD
PMID:19374891
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
G
Traf3
Tnf receptor-associated factor 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TRAF3 mRNA
CTD
PMID:19191707
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
G
Traf3ip2
Traf3 interacting protein 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TRAF3IP2 mRNA
CTD
PMID:19191707
NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
G
Trib3
tribbles pseudokinase 3
increases expression multiple interactions
EXP
4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]
CTD
PMID:24291486
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
G
Trim24
tripartite motif-containing 24
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TRIM24 mRNA
CTD
PMID:12419474
NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241
G
Trip13
thyroid hormone receptor interactor 13
increases expression decreases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TRIP13 mRNA 4-hydroxy-2-nonenal results in decreased expression of TRIP13 mRNA
CTD
PMID:19191707
NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
G
Trpa1
transient receptor potential cation channel, subfamily A, member 1
multiple interactions increases activity
ISO EXP
Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein] 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]
CTD
PMID:17684094 PMID:21689654
NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
G
Trpv4
transient receptor potential cation channel, subfamily V, member 4
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TRPV4 mRNA
CTD
PMID:19191707
NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
G
Tsc1
TSC complex subunit 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TSC1 mRNA
CTD
PMID:19191707
NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
G
Tsc2
TSC complex subunit 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TSC2 mRNA
CTD
PMID:12419474
NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
G
Tsc22d3
TSC22 domain family, member 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TSC22D3 mRNA
CTD
PMID:19191707
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
G
Tsg101
tumor susceptibility 101
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TSG101 mRNA
CTD
PMID:12419474
NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
G
Tspan31
tetraspanin 31
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TSPAN31 mRNA
CTD
PMID:12419474
NCBI chr 7:62,889,552...62,892,428
Ensembl chr 7:62,889,552...62,898,388
G
Tspyl2
TSPY-like 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TSPYL2 mRNA
CTD
PMID:19191707
NCBI chr X:21,439,478...21,445,208
Ensembl chr X:21,439,478...21,445,089
G
Tuba1b
tubulin, alpha 1B
affects binding
ISO
TUBA1B protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186
G
Tuba4a
tubulin, alpha 4A
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TUBA4A mRNA
CTD
PMID:19191707
NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
G
Txn1
thioredoxin 1
decreases activity affects metabolic processing
ISO
4-hydroxy-2-nonenal results in decreased activity of TXN protein 4-hydroxy-2-nonenal affects the metabolism of TXN protein
CTD
PMID:17982132
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
G
Txnrd1
thioredoxin reductase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of TXNRD1 mRNA
CTD
PMID:19191707
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
G
Tyr
tyrosinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of TYR mRNA
CTD
PMID:23489423
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
G
Uba1
ubiquitin-like modifier activating enzyme 1
multiple interactions
ISO
4-hydroxy-2-nonenal results in increased activity of and results in increased ubiquitination of UBA1 protein
CTD
PMID:25714994
NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636
G
Ube2a
ubiquitin-conjugating enzyme E2A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of UBE2A mRNA
CTD
PMID:12419474
NCBI chr X:116,114,339...116,125,076
Ensembl chr X:116,113,875...116,125,070
G
Ube2c
ubiquitin-conjugating enzyme E2C
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of UBE2C mRNA
CTD
PMID:19191707
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
G
Ube2d3
ubiquitin-conjugating enzyme E2D 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of UBE2D3 mRNA
CTD
PMID:19191707
NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
G
Ube2i
ubiquitin-conjugating enzyme E2I
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of UBE2I mRNA
CTD
PMID:19191707
NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443 Ensembl chr10:69,701,618...69,702,443
G
Ube2l6
ubiquitin-conjugating enzyme E2L 6
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of UBE2L6 mRNA
CTD
PMID:19191707
NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048
G
Ube2t
ubiquitin-conjugating enzyme E2T
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of UBE2T mRNA
CTD
PMID:19191707
NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
G
Ube4b
ubiquitination factor E4B
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of UBE4B mRNA
CTD
PMID:19191707
NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509
G
Uchl1
ubiquitin C-terminal hydrolase L1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of UCHL1 mRNA
CTD
PMID:19191707
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
G
Uhrf1
ubiquitin-like with PHD and ring finger domains 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of UHRF1 mRNA
CTD
PMID:19191707
NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
G
Ulk1
unc-51 like autophagy activating kinase 1
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ULK1 mRNA
CTD
PMID:19191707
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
G
Usf2
upstream transcription factor 2, c-fos interacting
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of USF2 mRNA
CTD
PMID:19191707
NCBI chr 1:86,174,703...86,185,942
Ensembl chr 1:86,174,703...86,185,617
G
Usp18
ubiquitin specific peptidase 18
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of USP18 mRNA
CTD
PMID:19191707
NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
G
Usp37
ubiquitin specific peptidase 37
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of USP37 mRNA
CTD
PMID:19191707
NCBI chr 9:76,018,863...76,118,732
Ensembl chr 9:76,018,991...76,084,044
G
Uvrag
UV radiation resistance associated
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of UVRAG mRNA
CTD
PMID:19191707
NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
G
Vdac2
voltage-dependent anion channel 2
affects binding
ISO
VDAC2 protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of VEGFA mRNA
CTD
PMID:19191707
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Vim
vimentin
affects binding
ISO
VIM protein binds to 4-hydroxy-2-nonenal
CTD
PMID:20043646
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Wnt6
Wnt family member 6
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of WNT6 mRNA
CTD
PMID:19191707
NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523
G
Wsb2
WD repeat and SOCS box-containing 2
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of WSB2 mRNA
CTD
PMID:19191707
NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640
G
Xaf1
XIAP associated factor 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of XAF1 mRNA
CTD
PMID:19191707
NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
G
Xbp1
X-box binding protein 1
increases splicing
EXP
4-hydroxy-2-nonenal results in increased splicing of XBP1 mRNA
CTD
PMID:24291486
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
G
Xdh
xanthine dehydrogenase
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of XDH mRNA
CTD
PMID:19191707
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
G
Xpc
XPC complex subunit, DNA damage recognition and repair factor
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of XPC mRNA
CTD
PMID:12419474
NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
G
Ybx3
Y box binding protein 3
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of YBX3 mRNA
CTD
PMID:12419474
NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161
G
Yes1
YES proto-oncogene 1, Src family tyrosine kinase
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of YES1 mRNA
CTD
PMID:12419474
NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
G
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of YWHAH mRNA
CTD
PMID:12419474
NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
G
Zbp1
Z-DNA binding protein 1
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ZBP1 mRNA
CTD
PMID:19191707
NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870
G
Zbtb20
zinc finger and BTB domain containing 20
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ZBTB20 mRNA
CTD
PMID:19191707
NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210
G
Zbtb7c
zinc finger and BTB domain containing 7C
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ZBTB7C mRNA
CTD
PMID:19191707
NCBI chr18:69,441,616...69,765,744
Ensembl chr18:69,441,616...69,765,297
G
Zdhhc18
zinc finger DHHC-type palmitoyltransferase 18
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ZDHHC18 mRNA
CTD
PMID:19191707
NCBI chr 5:145,821,534...145,859,989
Ensembl chr 5:145,831,446...145,859,993
G
Zfp36
zinc finger protein 36
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ZFP36 mRNA
CTD
PMID:12419474 PMID:19191707
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
G
Zfp367
zinc finger protein 367
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ZFP367 mRNA
CTD
PMID:19191707
NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
G
Zmat3
zinc finger, matrin type 3
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ZMAT3 mRNA
CTD
PMID:19191707
NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
G
Zscan29
zinc finger and SCAN domain containing 29
increases expression
ISO
4-hydroxy-2-nonenal results in increased expression of ZSCAN29 mRNA
CTD
PMID:19191707
Ensembl chr 3:108,131,018...108,140,486
G
Zwilch
zwilch kinetochore protein
decreases expression
ISO
4-hydroxy-2-nonenal results in decreased expression of ZWILCH mRNA
CTD
PMID:19191707
NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
G
Abca1
ATP binding cassette subfamily A member 1
multiple interactions increases degradation
ISO
glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] glycolaldehyde results in increased degradation of ABCA1 protein glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD
PMID:15983222
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
G
Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions
EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde
CTD
PMID:21376711
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
G
Apoa1
apolipoprotein A1
multiple interactions
ISO
glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD
PMID:15983222
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
G
Cat
catalase
decreases response to substance decreases activity
EXP
CAT protein results in decreased susceptibility to glycolaldehyde glycolaldehyde results in decreased activity of CAT protein
CTD
PMID:21376711 PMID:21378371
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ctss
cathepsin S
decreases activity
ISO
glycolaldehyde results in decreased activity of CTSS protein
CTD
PMID:16671891
NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
G
Glo1
glyoxalase 1
decreases activity
EXP
glycolaldehyde results in decreased activity of GLO1 protein
CTD
PMID:21378371
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19918
role
19894
application
19729
solvent
17050
formic acid
9050
formyl group
9012
aldehyde
9012
hydroxyaldehyde
805
(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal
0
(R)-3-hydroxy-4-oxobutanoic acid
0
2,3,4,5-tetrahydroxypentanal
0
2-deoxypentose
0
2-hydroxy-2-methylpropanal
0
20-oxoleukotriene B4
0
3,4-dihydroxymandelaldehyde +
0
4-hydroxynon-2-enal +
803
4-hydroxynonenal +
803
Melanoxazal
0
S-(4-hydroxy-1-oxononan-3-yl)cysteinylglycine
0
glycolaldehydes +
6
hydroxy fatty aldehyde +
0
lactaldehyde +
0
oleanolic aldehyde
0
Path 2
CHEBI ontology
19918
subatomic particle
19916
composite particle
19916
hadron
19916
baryon
19916
nucleon
19916
atomic nucleus
19916
atom
19916
main group element atom
19866
p-block element atom
19866
carbon group element atom
19811
carbon atom
19806
organic molecular entity
19806
organic group
18995
organic divalent group
18969
organodiyl group
18969
carbonyl group
18922
carbonyl compound
18922
carboxylic acid
18646
carboacyl group
17727
univalent carboacyl group
17727
formyl group
9012
aldehyde
9012
hydroxyaldehyde
805
(2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal
0
(R)-3-hydroxy-4-oxobutanoic acid
0
2,3,4,5-tetrahydroxypentanal
0
2-deoxypentose
0
2-hydroxy-2-methylpropanal
0
20-oxoleukotriene B4
0
3,4-dihydroxymandelaldehyde +
0
4-hydroxynon-2-enal +
803
4-hydroxynonenal +
803
Melanoxazal
0
S-(4-hydroxy-1-oxononan-3-yl)cysteinylglycine
0
glycolaldehydes +
6
hydroxy fatty aldehyde +
0
lactaldehyde +
0
oleanolic aldehyde
0