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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydroxyaldehyde
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Accession:CHEBI:50413 term browser browse the term
Synonyms:related_synonym: hydroxyaldehydes
 alt_id: CHEBI:24671;   CHEBI:5798
 xref: KEGG:C06461



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(E)-4-hydroxynon-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta4 glutathione S-transferase alpha 4 affects binding EXP (E)-4-hydroxynon-2-enal binds to Gsta4 protein RGD PMID:11018474 RGD:1641942 NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects binding EXP (E)-4-hydroxynon-2-enal binds to Gstp1 protein RGD PMID:11018474 RGD:1641942 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
4-hydroxynon-2-enal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ABCA1 mRNA CTD PMID:19191707 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects binding
increases expression
multiple interactions
ISO 4-hydroxy-2-nonenal binds to ABCC1 protein
4-hydroxy-2-nonenal results in increased expression of ABCC1 mRNA
[GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:15672542 PMID:19191707 PMID:21925487 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
multiple interactions
EXP
ISO
ABCC2 protein affects the export of 4-hydroxy-2-nonenal metabolite
4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]; Ascorbic Acid inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [ABCC2 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein]]
CTD PMID:12623073 PMID:19326901 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle affects binding EXP 4-hydroxy-2-nonenal binds to ACTA1 protein CTD PMID:15886073 NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Actb actin, beta affects binding ISO ACTB protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Actn1 actinin, alpha 1 affects binding ISO ACTN1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Actn4 actinin alpha 4 affects binding ISO ACTN4 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ADH7 mRNA CTD PMID:19191707 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Adi1 acireductone dioxygenase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ADI1 mRNA CTD PMID:19191707 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
JBrowse link
G Adora1 adenosine A1 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ADORA1 mRNA CTD PMID:12419474 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2b adenosine A2B receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ADORA2B mRNA CTD PMID:19191707 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ADRB2 mRNA CTD PMID:19191707 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Ago2 argonaute RISC catalytic component 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AGO2 mRNA CTD PMID:19191707 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Ago3 argonaute RISC catalytic component 3 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of AGO3 mRNA
4-hydroxy-2-nonenal results in increased expression of AGO3 mRNA
CTD PMID:19191707 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
JBrowse link
G Agrn agrin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AGRN mRNA CTD PMID:19191707 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
JBrowse link
G Agt angiotensinogen affects binding
multiple interactions
ISO 4-hydroxy-2-nonenal binds to AGT protein modified form; AGT protein modified form binds to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in increased lipidation of AGT protein modified form; [AGT protein modified form results in increased chemical synthesis of Lipid Peroxides] which results in increased abundance of 4-hydroxy-2-nonenal; [Ascorbic Acid co-treated with Copper Sulfate] promotes the reaction [AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; AGT protein modified form results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]
CTD PMID:20977208 PMID:26111765 PMID:31144504 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahsa2 activator of HSP90 ATPase homolog 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of AHSA2 mRNA CTD PMID:19191707 NCBI chr14:97,476,304...97,485,725
Ensembl chr14:97,476,817...97,485,657
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of AIFM1 mRNA CTD PMID:19191707 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akna AT-hook transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AKNA mRNA CTD PMID:19191707 NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases reduction
increases expression
ISO AKR1A1 protein results in increased reduction of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of AKR1A1 mRNA
CTD PMID:10510318 PMID:19191707 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 affects reduction
increases reduction
ISO AKR1B1 protein affects the reduction of 4-hydroxy-2-nonenal
AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal; AKR1B1 protein results in increased reduction of 4-hydroxy-2-nonenal metabolite
CTD PMID:9890881 PMID:10510318 PMID:11306073 PMID:21329684 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases reduction
multiple interactions
increases metabolic processing
ISO AKR1B10 protein results in increased reduction of 4-hydroxy-2-nonenal
Oleanolic Acid inhibits the reaction [AKR1B10 protein results in increased metabolism of 4-hydroxy-2-nonenal]
CTD PMID:19013440 PMID:21329684 PMID:27417252 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression
increases response to substance
multiple interactions
ISO 4-hydroxy-2-nonenal results in increased expression of AKR1C3 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR1C3 protein
AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
CTD PMID:22964423 PMID:30849339 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases response to substance
affects response to substance
increases response to substance
multiple interactions
increases expression
ISO AKR7A2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
AKR7A2 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal
7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal results in increased expression of AKR7A2 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR7A2 protein
CTD PMID:22001351 PMID:22964423 PMID:30849339 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects response to substance
multiple interactions
increases activity
decreases phosphorylation
EXP
ISO
AKT1 protein affects the susceptibility to 4-hydroxy-2-nonenal
AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]
4-hydroxy-2-nonenal results in increased activity of AKT1 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of AKT1 protein
CTD PMID:18805481 PMID:23845594 PMID:24825450 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alb albumin multiple interactions ISO [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein; [ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein]; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]; sulforaphane inhibits the reaction [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] CTD PMID:33007382 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases metabolic processing
multiple interactions
increases oxidation
ISO ALDH1A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH1A1 protein results in increased oxidation of 4-hydroxy-2-nonenal
CTD PMID:21256123 PMID:21967605 PMID:22339434 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions
increases oxidation
ISO [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein; ALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]
CTD PMID:21967605 PMID:22339434 PMID:25263579 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 decreases response to substance
affects metabolic processing
affects response to substance
increases metabolic processing
multiple interactions
increases oxidation
ISO
EXP
ALDH3A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein affects the susceptibility to 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
[APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
ALDH3A1 protein results in increased oxidation of 4-hydroxy-2-nonenal
CTD PMID:11018474 PMID:11306050 PMID:15905174 PMID:21256123 PMID:21967605 More... NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding
decreases response to substance
ISO 4-hydroxy-2-nonenal binds to ALDH3B1 protein
ALDH3B1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:20699116 NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ALDH6A1 mRNA CTD PMID:19191707 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 increases metabolic processing
decreases response to substance
ISO ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal
ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:21338592 NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A affects binding ISO ALDOA protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Aldoc aldolase, fructose-bisphosphate C multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to ALDOA protein] CTD PMID:20889679 NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ALOX5AP mRNA CTD PMID:19191707 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Alpk1 alpha-kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ALPK1 mRNA CTD PMID:19191707 NCBI chr 2:216,126,939...216,247,180
Ensembl chr 2:216,128,825...216,247,157
JBrowse link
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ALS2 mRNA CTD PMID:19191707 NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737
JBrowse link
G Amph amphiphysin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AMPH mRNA CTD PMID:12419474 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315
JBrowse link
G Anln anillin, actin binding protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ANLN mRNA CTD PMID:19191707 NCBI chr 8:20,858,227...20,921,602
Ensembl chr 8:20,858,228...20,921,538
JBrowse link
G Anp32a acidic nuclear phosphoprotein 32 family member A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ANP32A mRNA CTD PMID:19191707 NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443
JBrowse link
G Aoah acyloxyacyl hydrolase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AOAH mRNA CTD PMID:19191707 NCBI chr17:43,808,110...44,049,458
Ensembl chr17:43,809,638...44,049,148
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of AOX1 mRNA CTD PMID:19191707 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Ap1s3 adaptor related protein complex 1 subunit sigma 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AP1S3 mRNA CTD PMID:19191707 NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798
JBrowse link
G Apc APC regulator of WNT signaling pathway decreases expression
multiple interactions
affects response to substance
affects oxidation
ISO 4-hydroxy-2-nonenal results in decreased expression of APC mRNA
[APC protein affects the oxidation of 4-hydroxy-2-nonenal] which affects the abundance of 4-hydroxynonenoic acid; [APC protein mutant form results in increased expression of ALDH1A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of ALDH3A1 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of GSTA4 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal; [APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
APC protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD PMID:12419474 PMID:21967605 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of APEX1 mRNA CTD PMID:19191707 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoa1 apolipoprotein A1 affects binding ISO 4-hydroxy-2-nonenal binds to APOA1 protein CTD PMID:18778096 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apod apolipoprotein D decreases abundance ISO APOD protein results in decreased abundance of 4-hydroxy-2-nonenal CTD PMID:28182653 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G App amyloid beta precursor protein decreases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased expression of APP mRNA
[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; [APP protein modified form inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide]] which results in increased chemical synthesis of 4-hydroxy-2-nonenal; Deferoxamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]
CTD PMID:12419474 PMID:17964426 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGAP11A mRNA CTD PMID:19191707 NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
JBrowse link
G Arhgap22 Rho GTPase activating protein 22 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ARHGAP22 mRNA CTD PMID:19191707 NCBI chr16:8,473,806...8,631,552
Ensembl chr16:8,476,306...8,631,548
JBrowse link
G Arhgap27 Rho GTPase activating protein 27 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ARHGAP27 mRNA CTD PMID:19191707 NCBI chr10:88,280,470...88,313,225
Ensembl chr10:88,280,455...88,313,185
JBrowse link
G Arhgap5 Rho GTPase activating protein 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGAP5 mRNA CTD PMID:12419474 NCBI chr 6:69,975,904...70,039,299
Ensembl chr 6:69,976,214...70,037,660
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGDIA mRNA CTD PMID:12419474 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Arhgef3 Rho guanine nucleotide exchange factor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNA CTD PMID:19191707 NCBI chr16:2,301,573...2,581,951
Ensembl chr16:2,300,138...2,581,945
JBrowse link
G Arid5a AT-rich interaction domain 5A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ARID5A mRNA CTD PMID:19191707 NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ARRDC3 mRNA CTD PMID:19191707 NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of ASF1B mRNA
4-hydroxy-2-nonenal results in increased expression of ASF1B mRNA
CTD PMID:19191707 NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
JBrowse link
G Aspm assembly factor for spindle microtubules decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ASPM mRNA CTD PMID:19191707 NCBI chr13:51,074,849...51,123,755
Ensembl chr13:51,074,849...51,123,755
JBrowse link
G Atad5 ATPase family, AAA domain containing 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ATAD5 mRNA CTD PMID:19191707 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATF3 protein CTD PMID:19041636 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of ATF4 mRNA; 4-hydroxy-2-nonenal results in increased expression of ATF4 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]
CTD PMID:24291486 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]
CTD PMID:24291486 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atg5 autophagy related 5 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATG5 mRNA CTD PMID:35550146 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATG7 mRNA CTD PMID:35550146 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATM mRNA CTD PMID:19191707 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ATP1B3 mRNA CTD PMID:12419474 NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects binding ISO 4-hydroxy-2-nonenal binds to ATP5F1A protein CTD PMID:19374891 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ATP6V1A mRNA CTD PMID:19191707 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G Atr ATR serine/threonine kinase decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of ATR mRNA
4-hydroxy-2-nonenal results in increased expression of ATR mRNA
CTD PMID:12419474 PMID:19191707 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Avil advillin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AVIL mRNA CTD PMID:19191707 NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071
JBrowse link
G B2m beta-2 microglobulin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of B2M mRNA CTD PMID:19191707 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BABAM2 mRNA CTD PMID:19191707 NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of BAD mRNA
4-hydroxy-2-nonenal results in increased expression of BAD protein
CTD PMID:12419474 PMID:24825450 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Batf2 basic leucine zipper ATF-like transcription factor 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BATF2 mRNA CTD PMID:19191707 NCBI chr 1:203,467,291...203,479,428
Ensembl chr 1:203,468,097...203,475,889
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO
EXP
4-hydroxy-2-nonenal results in decreased expression of BAX mRNA
4-hydroxy-2-nonenal results in increased expression of BAX protein
CTD PMID:12419474 PMID:15607904 PMID:21187080 PMID:24825450 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions
increases expression
EXP 4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of BBC3 mRNA] CTD PMID:24291486 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bbx BBX high mobility group box domain containing increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BBX mRNA CTD PMID:19191707 NCBI chr11:50,381,249...50,628,934
Ensembl chr11:50,381,247...50,623,251
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCL2A1B mRNA CTD PMID:19191707 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCL2L1 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BCL2L11 mRNA CTD PMID:19191707 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcl3 BCL3, transcription coactivator decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BCL3 mRNA CTD PMID:19191707 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BCL6 mRNA CTD PMID:19191707 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA
CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA]
CTD PMID:16337876 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bgn biglycan multiple interactions ISO [[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal CTD PMID:35234341 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BHLHE40 mRNA CTD PMID:19191707 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BHLHE41 mRNA CTD PMID:19191707 NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BID mRNA CTD PMID:19191707 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of BIRC5 mRNA
4-hydroxy-2-nonenal results in decreased expression of BIRC5 mRNA
CTD PMID:19191707 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Blm BLM RecQ like helicase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BLM mRNA CTD PMID:19191707 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Blvrb biliverdin reductase B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BLVRB mRNA CTD PMID:19191707 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BMP1 mRNA CTD PMID:12419474 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776
JBrowse link
G Bnip3 BCL2 interacting protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BNIP3 mRNA CTD PMID:12419474 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BRAF mRNA CTD PMID:12419474 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BUB1 mRNA CTD PMID:19191707 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of BUB1B mRNA CTD PMID:19191707 NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of BZW1 mRNA CTD PMID:19191707 NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
JBrowse link
G C5ar1 complement C5a receptor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of C5AR1 mRNA CTD PMID:19191707 NCBI chr 1:76,948,622...76,959,826 JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CACNA1A mRNA CTD PMID:19191707 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cadps calcium dependent secretion activator increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CADPS mRNA CTD PMID:19191707 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion EXP 4-hydroxy-2-nonenal results in increased secretion of CALCA protein CTD PMID:17684094 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CALCOCO1 mRNA CTD PMID:19191707 NCBI chr 7:133,834,705...133,849,515
Ensembl chr 7:133,834,707...133,849,422
JBrowse link
G Calr3 calreticulin 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CALR3 mRNA CTD PMID:19191707 NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CAMK1D mRNA CTD PMID:19191707 NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 affects binding ISO CAP1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Capn2 calpain 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CAPN2 mRNA CTD PMID:12419474 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Capns1 calpain, small subunit 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CAPNS1 mRNA CTD PMID:12419474 NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO CAPZB protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
JBrowse link
G Car12 carbonic anhydrase 12 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CAR12 mRNA CTD PMID:19191707 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Car2 carbonic anhydrase 2 affects binding ISO CA2 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CARHSP1 mRNA CTD PMID:19191707 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASK mRNA CTD PMID:12419474 NCBI chr  X:8,899,500...9,243,014
Ensembl chr  X:8,899,833...9,238,694
JBrowse link
G Casp1 caspase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP1 mRNA CTD PMID:19191707 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO
EXP
4-hydroxy-2-nonenal results in increased cleavage of and results in increased activity of CASP3 protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP3 protein]
4-hydroxy-2-nonenal results in increased cleavage of CASP3 protein
CTD PMID:11488593 PMID:16322078 PMID:16337876 PMID:17263905 PMID:19326901 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP4 mRNA CTD PMID:19191707 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP7 mRNA CTD PMID:19191707 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CASP8 mRNA CTD PMID:12419474 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased activity of CASP9 protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of CASP9 protein]
CTD PMID:16322078 PMID:17263905 PMID:21187080 PMID:24825450 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CAT mRNA CTD PMID:19191707 PMID:24423726 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cblb Cbl proto-oncogene B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CBLB mRNA CTD PMID:12419474 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of CCL17 mRNA
4-hydroxy-2-nonenal results in increased expression of CCL17 mRNA
CTD PMID:19191707 NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL22 mRNA CTD PMID:19191707 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL3 mRNA CTD PMID:12419474 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL4 mRNA CTD PMID:19191707 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]
4-hydroxy-2-nonenal results in decreased expression of CCL5 mRNA
CTD PMID:19191707 PMID:19627980 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL7 mRNA CTD PMID:19191707 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNA2 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNB1 mRNA CTD PMID:19191707 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CCND1]
4-hydroxy-2-nonenal results in increased expression of CCND1; 4-hydroxy-2-nonenal results in increased expression of CCND1 mRNA
CTD PMID:16328008 PMID:19191707 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCND2 protein CTD PMID:15607904 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CCND3 protein] CTD PMID:33007382 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccnf cyclin F decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNF mRNA CTD PMID:19191707 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Ccng1 cyclin G1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CCNG1 mRNA CTD PMID:19191707 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccng2 cyclin G2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNG2 mRNA CTD PMID:19191707 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccnk cyclin K decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNK mRNA CTD PMID:12419474 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191
JBrowse link
G Ccnt1 cyclin T1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCNT1 mRNA CTD PMID:12419474 NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CCR1 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Cd14 CD14 molecule increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD14 mRNA CTD PMID:19191707 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd300a Cd300a molecule increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD300A mRNA CTD PMID:19191707 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
G Cd300lb CD300 molecule-like family member b increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD300LB mRNA CTD PMID:19191707 NCBI chr10:99,964,801...99,974,790
Ensembl chr10:99,964,801...99,974,790
JBrowse link
G Cd300lf Cd300 molecule-like family member F decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD300LF mRNA CTD PMID:19191707 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041
JBrowse link
G Cd36 CD36 molecule increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CD36 mRNA CTD PMID:19191707 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd40 CD40 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD40 mRNA CTD PMID:19191707 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Cd44 CD44 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD44 mRNA CTD PMID:19191707 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd47 Cd47 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD47 mRNA CTD PMID:12419474 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
JBrowse link
G Cd83 CD83 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD83 mRNA CTD PMID:19191707 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cd86 CD86 molecule decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CD86 mRNA CTD PMID:19191707 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDC20 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDC25A mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDC25C mRNA CTD PMID:19191707 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdca2 cell division cycle associated 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDCA2 mRNA CTD PMID:19191707 NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in decreased expression of CDH1 protein CTD PMID:34503147 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDH2 mRNA CTD PMID:12419474 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDH3 mRNA CTD PMID:12419474 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO 4-hydroxy-2-nonenal binds to and results in increased alkylation of and results in decreased activity of CDK2 protein CTD PMID:26910110 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in increased expression of CDK6 mRNA
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of CDK6 protein]
CTD PMID:19191707 PMID:33007382 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDK9 mRNA CTD PMID:12419474 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CDKN1A protein CTD PMID:15607904 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDKN1C mRNA CTD PMID:12419474 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CDKN2D mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CEBPA mRNA CTD PMID:19191707 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cenpa centromere protein A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CENPA mRNA CTD PMID:19191707 NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
JBrowse link
G Cep290 centrosomal protein 290 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CEP290 mRNA CTD PMID:19191707 NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO 4-hydroxy-2-nonenal results in decreased activity of CES1 protein CTD PMID:21878322 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H increases activity ISO 4-hydroxy-2-nonenal results in increased activity of CES2 protein CTD PMID:21878322 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cfb complement factor B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CFB mRNA CTD PMID:19191707 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfl1 cofilin 1 affects binding ISO CFL1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CHEK1 mRNA CTD PMID:19191707 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chml CHM like Rab escort protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CHML mRNA CTD PMID:19191707 NCBI chr13:87,609,647...87,619,868
Ensembl chr13:87,589,298...87,619,862
JBrowse link
G Cilk1 ciliogenesis associated kinase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CILK1 mRNA CTD PMID:19191707 NCBI chr 8:78,984,075...79,042,695
Ensembl chr 8:78,984,258...79,042,691
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CISH mRNA CTD PMID:19191707 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CKS1B mRNA CTD PMID:19191707 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CKS2 mRNA CTD PMID:19191707 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Cldn11 claudin 11 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CLDN11 mRNA CTD PMID:19191707 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Clec12a C-type lectin domain family 12, member A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CLEC12A mRNA CTD PMID:19191707 NCBI chr 4:162,798,125...162,816,757
Ensembl chr 4:162,798,125...162,816,753
JBrowse link
G Clec4a C-type lectin domain family 4, member A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CLEC4N mRNA CTD PMID:19191707 NCBI chr 4:156,340,439...156,434,212
Ensembl chr 4:156,414,688...156,432,402
JBrowse link
G Clec4d C-type lectin domain family 4, member D increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CLEC4D mRNA CTD PMID:19191707 NCBI chr 4:156,589,591...156,599,279
Ensembl chr 4:156,589,792...156,598,848
JBrowse link
G Clec5a C-type lectin domain containing 5A decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of CLEC5A mRNA
4-hydroxy-2-nonenal results in increased expression of CLEC5A mRNA
CTD PMID:19191707 NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859
JBrowse link
G Clk3 CDC-like kinase 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CLK3 mRNA CTD PMID:12419474 NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO 4-hydroxy-2-nonenal results in increased expression of COL1A1 mRNA; 4-hydroxy-2-nonenal results in increased expression of COL1A1 protein CTD PMID:14672615 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Comt catechol-O-methyltransferase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of COMT mRNA CTD PMID:12419474 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cp ceruloplasmin decreases expression
affects abundance
ISO 4-hydroxy-2-nonenal results in decreased expression of CP mRNA
CP protein affects the abundance of 4-hydroxy-2-nonenal
CTD PMID:12572680 PMID:19191707 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpe carboxypeptidase E decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CPE mRNA CTD PMID:12419474 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
increases phosphorylation
ISO 4-hydroxy-2-nonenal results in decreased expression of CREB1 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of CREB1 protein
CTD PMID:12419474 PMID:16337876 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions EXP CREBBP protein inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of BDNF mRNA] CTD PMID:16337876 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CREG1 mRNA CTD PMID:19191707 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CROT mRNA CTD PMID:19191707 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CRY1 mRNA CTD PMID:19191707 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CRY2 mRNA CTD PMID:19191707 NCBI chr 3:78,374,995...78,405,001
Ensembl chr 3:78,374,995...78,404,965
JBrowse link
G Cryz crystallin zeta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CRYZ mRNA CTD PMID:12419474 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Csf1r colony stimulating factor 1 receptor increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CSF1R mRNA CTD PMID:19191707 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of CSF3 mRNA
4-hydroxy-2-nonenal results in increased expression of CSF3 mRNA; 4-hydroxy-2-nonenal results in increased expression of CSF3 protein
CTD PMID:19191707 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Csnk1g2 casein kinase 1, gamma 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CSNK1G2 mRNA CTD PMID:12419474 NCBI chr 7:9,076,739...9,095,082
Ensembl chr 7:9,076,740...9,095,052
JBrowse link
G Csrnp1 cysteine and serine rich nuclear protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of AXUD1 mRNA CTD PMID:19191707 NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of CTNNB1 protein CTD PMID:12419474 PMID:24825450 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA] CTD PMID:35550146 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CTSL mRNA CTD PMID:12419474 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cttn cortactin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CTTN mRNA CTD PMID:12419474 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cux1 cut-like homeobox 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CUX1 mRNA CTD PMID:12419474 NCBI chr12:20,107,062...20,425,868
Ensembl chr12:20,107,311...20,425,866
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein] CTD PMID:19627980 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CXCL14 mRNA CTD PMID:19191707 NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CXCL1 mRNA CTD PMID:19191707 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of CXCR4 mRNA CTD PMID:19191707 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cybb cytochrome b-245 beta chain increases abundance ISO CYBB protein results in increased abundance of 4-hydroxy-2-nonenal CTD PMID:19417757 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal affects the localization of CYCS protein
pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal affects the localization of CYCS protein]
CTD PMID:16322078 PMID:17263905 PMID:21187080 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP1A2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CYP1B1 mRNA CTD PMID:12419474 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [CYP2B6 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2B6 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2B6 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C29 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2C29 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2C29 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO [CYP2J2 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid; [CYP2J2 protein results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; CYP2J2 protein results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal CTD PMID:21766881 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1,4-dihydroxy-2-nonene; [CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of and results in increased oxidation of 4-hydroxy-2-nonenal; [CYP3A4 protein results in increased oxidation of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 4-hydroxy-2-nonenoic acid CTD PMID:21766881 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CYSLTR1 mRNA CTD PMID:19191707 NCBI chr  X:71,661,421...71,690,012
Ensembl chr  X:71,663,821...71,690,121
JBrowse link
G Cyth4 cytohesin 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of CYTH4 mRNA CTD PMID:19191707 NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741
JBrowse link
G Dap death-associated protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of DAP mRNA CTD PMID:19191707 NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DAPK1 mRNA CTD PMID:12419474 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dbf4 DBF4-CDC7 kinase regulatory subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DBF4 mRNA CTD PMID:19191707 NCBI chr 4:25,676,570...25,701,152
Ensembl chr 4:25,676,634...25,701,066
JBrowse link
G Dcn decorin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DCN mRNA CTD PMID:19191707 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA; 4-hydroxy-2-nonenal results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of DDIT3 mRNA]
CTD PMID:24291486 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DDIT4 mRNA CTD PMID:19191707 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DDR2 mRNA CTD PMID:12419474 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Denr density regulated reinitiation and release factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DENR mRNA CTD PMID:19191707 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
JBrowse link
G Dffa DNA fragmentation factor subunit alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DFFA mRNA CTD PMID:12419474 NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Dffb DNA fragmentation factor subunit beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DFFB mRNA CTD PMID:12419474 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628
JBrowse link
G Dgkh diacylglycerol kinase, eta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DGKH mRNA CTD PMID:19191707 NCBI chr15:53,981,079...54,150,470
Ensembl chr15:53,991,481...54,150,706
JBrowse link
G Dhx58 DEXH-box helicase 58 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DHX58 mRNA CTD PMID:19191707 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DIO2 mRNA CTD PMID:19191707 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of DLGAP5 mRNA
4-hydroxy-2-nonenal results in increased expression of DLGAP5 mRNA
CTD PMID:19191707 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of DNAJB4 mRNA CTD PMID:19191707 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DNAJC3 mRNA CTD PMID:12419474 NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal increases expression ISO 4-hydroxy-2-nonenal results in increased expression of DNASE2A mRNA CTD PMID:19191707 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DNPH1 mRNA CTD PMID:12419474 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 affects binding ISO 4-hydroxy-2-nonenal binds to DPYSL2 protein CTD PMID:19374891 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP 4-hydroxy-2-nonenal results in decreased expression of DRD2 protein CTD PMID:20570720 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dst dystonin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of DST mRNA CTD PMID:12419474 NCBI chr 9:36,135,657...36,529,617
Ensembl chr 9:36,135,284...36,529,615
JBrowse link
G Dynlt3 dynein light chain Tctex-type 3 affects binding ISO DYNLT3 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr  X:13,327,933...13,337,139
Ensembl chr  X:13,327,892...13,337,139
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of E2F1 mRNA CTD PMID:12419474 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of E2F2 mRNA CTD PMID:19191707 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of E2F8 mRNA CTD PMID:19191707 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Echdc3 enoyl CoA hydratase domain containing 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ECHDC3 mRNA CTD PMID:19191707 NCBI chr17:72,070,697...72,093,519
Ensembl chr17:72,070,668...72,093,516
JBrowse link
G Edn1 endothelin 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EDN1 mRNA CTD PMID:19191707 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 decreases expression EXP 4-hydroxy-2-nonenal results in decreased expression of EEF2 protein CTD PMID:16469450 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Efna4 ephrin A4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EFNA4 mRNA CTD PMID:12419474 NCBI chr 2:174,748,729...174,752,979
Ensembl chr 2:174,748,724...174,752,979
JBrowse link
G Eid3 EP300 interacting inhibitor of differentiation 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EID3 mRNA CTD PMID:19191707 NCBI chr 7:20,860,073...20,861,395 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO 4-hydroxy-2-nonenal results in increased phosphorylation of EIF2A protein CTD PMID:19041636 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EIF2AK2 mRNA CTD PMID:19191707 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO 4-hydroxy-2-nonenal results in increased phosphorylation of EIF2AK3 protein CTD PMID:19041636 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of EIF2S1 protein] CTD PMID:24291486 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EIF4E mRNA CTD PMID:19191707 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EIF4E2 mRNA CTD PMID:19191707 NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases phosphorylation EXP 4-hydroxy-2-nonenal results in increased phosphorylation of EIF4EBP1 protein CTD PMID:9890986 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EIF5A mRNA CTD PMID:19191707 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
JBrowse link
G Elk1 ETS transcription factor ELK1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ELK1 mRNA CTD PMID:12419474 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Eloc elongin C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ELOC mRNA CTD PMID:12419474 NCBI chr 5:2,661,527...2,677,893
Ensembl chr 5:2,661,724...2,677,890
JBrowse link
G Elp1 elongator acetyltransferase complex subunit 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ELP1 mRNA CTD PMID:12419474 NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762
JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EME1 mRNA CTD PMID:19191707 NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435
JBrowse link
G Eno1 enolase 1 affects binding ISO 4-hydroxy-2-nonenal binds to ENO1 protein CTD PMID:19374891 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of EPHX1 mRNA CTD PMID:19191707 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EPS15 mRNA CTD PMID:12419474 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221
JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EPS8 mRNA CTD PMID:12419474 NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
JBrowse link
G Epsti1 epithelial stromal interaction 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EPSTI1 mRNA CTD PMID:19191707 NCBI chr15:53,283,964...53,382,192
Ensembl chr15:53,284,216...53,382,191
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERBB2 mRNA CTD PMID:12419474 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERBB4 mRNA CTD PMID:12419474 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC1 mRNA CTD PMID:19191707 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC2 mRNA CTD PMID:12419474 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC5 mRNA CTD PMID:12419474 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
JBrowse link
G Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERCC6L mRNA CTD PMID:19191707 NCBI chr  X:67,245,414...67,261,222
Ensembl chr  X:67,245,414...67,280,756
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ERN1 mRNA CTD PMID:19191707 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ESPL1 mRNA CTD PMID:19191707 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETS1 mRNA CTD PMID:12419474 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETS2 mRNA CTD PMID:12419474 NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
JBrowse link
G Etv3 ETS variant transcription factor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETV3 mRNA CTD PMID:12419474 NCBI chr 2:172,965,461...172,980,320
Ensembl chr 2:172,965,588...172,980,314
JBrowse link
G Etv6 ETS variant transcription factor 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ETV6 mRNA CTD PMID:12419474 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
JBrowse link
G Ezr ezrin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of EZR mRNA CTD PMID:12419474 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
JBrowse link
G F10 coagulation factor X increases expression ISO 4-hydroxy-2-nonenal results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of F2R mRNA CTD PMID:12419474 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of F3 mRNA CTD PMID:19191707 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fancd2 FA complementation group D2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FANCD2 mRNA CTD PMID:19191707 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fastk Fas-activated serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FASTK mRNA CTD PMID:12419474 NCBI chr 4:10,732,273...10,736,332
Ensembl chr 4:10,732,256...10,737,430
JBrowse link
G Fbxl17 F-box and leucine-rich repeat protein 17 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXL17 mRNA CTD PMID:19191707 NCBI chr 9:102,780,573...103,206,978
Ensembl chr 9:102,782,440...103,208,950
JBrowse link
G Fbxl20 F-box and leucine-rich repeat protein 20 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of FBXL20 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXL20 mRNA
CTD PMID:19191707 NCBI chr10:83,080,568...83,143,680
Ensembl chr10:83,086,551...83,144,162
JBrowse link
G Fbxo15 F-box protein 15 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FBXO15 mRNA CTD PMID:19191707 NCBI chr18:78,319,577...78,634,695
Ensembl chr18:78,319,534...78,390,765
JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXO22 mRNA CTD PMID:19191707 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXO30 mRNA CTD PMID:19191707 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
JBrowse link
G Fbxo31 F-box protein 31 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FBXO31 mRNA CTD PMID:19191707 NCBI chr19:49,624,813...49,656,052
Ensembl chr19:49,627,686...49,656,010
JBrowse link
G Fbxo39 F-box protein 39 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FBXO39 mRNA CTD PMID:19191707 NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906
JBrowse link
G Fbxo5 F-box protein 5 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of FBXO5 mRNA
4-hydroxy-2-nonenal results in increased expression of FBXO5 mRNA
CTD PMID:19191707 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fcgr1a Fc gamma receptor 1A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FCGR1 mRNA; 4-hydroxy-2-nonenal results in decreased expression of FCGR1A mRNA CTD PMID:19191707 NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994
JBrowse link
G Fcgr2b Fc gamma receptor 2B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FCGR2B mRNA CTD PMID:19191707 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fech ferrochelatase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FECH mRNA CTD PMID:12419474 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
JBrowse link
G Fem1c fem-1 homolog C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FEM1C mRNA CTD PMID:19191707 NCBI chr18:39,232,900...39,258,692
Ensembl chr18:39,232,900...39,258,692
JBrowse link
G Fen1 flap structure-specific endonuclease 1 increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of FEN1 mRNA
4-hydroxy-2-nonenal results in decreased expression of FEN1 mRNA
CTD PMID:19191707 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FGFR1 mRNA CTD PMID:12419474 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of FGR mRNA
4-hydroxy-2-nonenal results in decreased expression of FGR mRNA
CTD PMID:19191707 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Fkbp14 FKBP prolyl isomerase 14 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FKBP14 mRNA CTD PMID:19191707 NCBI chr 4:83,705,531...83,721,515
Ensembl chr 4:83,705,652...83,721,528
JBrowse link
G Fkbpl FKBP prolyl isomerase like increases expression ISO 4-hydroxy-2-nonenal results in increased expression of FKBPL mRNA CTD PMID:19191707 NCBI chr20:4,099,845...4,101,315
Ensembl chr20:4,099,806...4,101,368
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased expression of FOS mRNA
4-hydroxy-2-nonenal results in decreased expression of FOS protein
resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of FOS protein]
CTD PMID:12419474 PMID:16322078 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]] CTD PMID:9890986 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FOXM1 mRNA CTD PMID:19191707 NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO FOXO3 protein inhibits the reaction [SRT1720 inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]] CTD PMID:24633890 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp1 forkhead box P1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FOXP1 mRNA CTD PMID:19191707 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258
JBrowse link
G Fubp1 far upstream element binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of FUBP1 mRNA CTD PMID:12419474 NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
JBrowse link
G Fxn frataxin multiple interactions ISO 4-hydroxy-2-nonenal affects the reaction [Ethanol affects the expression of FXN protein] CTD PMID:33017621 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of G6PDX mRNA CTD PMID:19191707 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GABARAPL1 mRNA CTD PMID:19191707 NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GADD45A mRNA]
CTD PMID:19191707 PMID:24291486 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gak cyclin G associated kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GAK mRNA CTD PMID:12419474 NCBI chr14:1,089,853...1,164,098
Ensembl chr14:1,089,866...1,216,398
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO [Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]] which results in decreased activity of GAPDH protein; [Hydroxyurea results in increased abundance of Free Radicals] promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein]; Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GAPDH protein] CTD PMID:20889679 PMID:23696560 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GATA3 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Gatad2b GATA zinc finger domain containing 2B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GATAD2B mRNA CTD PMID:19191707 NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542
JBrowse link
G Gatb glutamyl-tRNA amidotransferase subunit B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GATB mRNA CTD PMID:19191707 NCBI chr 2:170,930,547...171,017,133
Ensembl chr 2:170,930,542...171,016,695
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GBP1 mRNA CTD PMID:19191707 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131
JBrowse link
G Gbp4 guanylate binding protein 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GBP3 mRNA CTD PMID:19191707 NCBI chr 2:231,304,910...231,318,883
Ensembl chr 2:231,305,244...231,318,879
JBrowse link
G Gbp5 guanylate binding protein 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GBP5 mRNA CTD PMID:19191707 NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased expression of GCLC mRNA
4-hydroxy-2-nonenal results in increased expression of GCLC protein
NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]
CTD PMID:19191707 PMID:24291486 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GCLM mRNA CTD PMID:19191707 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GEN1 mRNA CTD PMID:19191707 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401
JBrowse link
G Ggnbp1 gametogenetin binding protein 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GGNBP1 mRNA CTD PMID:19191707 NCBI chr20:5,109,849...5,116,185
Ensembl chr20:5,099,311...5,116,183
JBrowse link
G Gna13 G protein subunit alpha 13 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNA13 mRNA CTD PMID:19191707 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774
JBrowse link
G Gnaq G protein subunit alpha q increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GNAQ mRNA CTD PMID:19191707 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gnas GNAS complex locus decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNAS mRNA CTD PMID:12419474 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnat3 G protein subunit alpha transducin 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GNAT3 mRNA CTD PMID:19191707 NCBI chr 4:17,162,500...17,212,283
Ensembl chr 4:17,162,490...17,212,283
JBrowse link
G Gnb1 G protein subunit beta 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNB1 mRNA CTD PMID:12419474 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
JBrowse link
G Gnb2 G protein subunit beta 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GNB2 mRNA CTD PMID:12419474 NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions ISO Hydroxyurea promotes the reaction [4-hydroxy-2-nonenal binds to GOT2 protein] CTD PMID:20889679 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpr183 G protein-coupled receptor 183 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GPR183 mRNA CTD PMID:19191707 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559
JBrowse link
G Gpx1 glutathione peroxidase 1 increases abundance ISO GPX1 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal CTD PMID:24296279 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GPX2 mRNA CTD PMID:12419474 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
decreases phosphorylation
ISO 4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNA
4-hydroxy-2-nonenal results in decreased phosphorylation of GSK3B protein
CTD PMID:12419474 PMID:24825450 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSN mRNA CTD PMID:19191707 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSR mRNA CTD PMID:19191707 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSS mRNA CTD PMID:19191707 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases response to substance
increases expression
affects metabolic processing
multiple interactions
ISO
EXP
GSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA
GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
CTD PMID:9799558 PMID:11256969 PMID:15829614 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions EXP [GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog CTD PMID:11256969 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions
affects metabolic processing
increases expression
ISO
EXP
GSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal
GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal; GSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog
4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA; 4-hydroxy-2-nonenal results in increased expression of GSTA4 protein
CTD PMID:2619714 PMID:7878679 PMID:8142470 PMID:8203886 PMID:9461507 More... NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA CTD PMID:19191707 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
affects metabolic processing
ISO
EXP
[GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; [GSTM1 protein co-treated with ABCC1 protein] results in increased susceptibility to 4-hydroxy-2-nonenal
GSTM1 protein affects the metabolism of 4-hydroxy-2-nonenal analog
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
CTD PMID:11256969 PMID:21925487 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases response to substance
multiple interactions
affects metabolic processing
ISO
EXP
GSTM2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog
GSTM2 protein affects the metabolism of 4-hydroxy-2-nonenal analog
CTD PMID:11256969 PMID:15829614 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
decreases response to substance
increases expression
affects binding
decreases expression
ISO
EXP
4-hydroxy-2-nonenal binds to and results in decreased activity of GSTP1 protein
GSTP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of GSTP1 protein
4-hydroxy-2-nonenal analog binds to GSTP1
4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein
Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]
4-hydroxy-2-nonenal results in increased expression of GSTP1 mRNA
CTD PMID:9463521 PMID:11600134 PMID:15829614 PMID:18232660 PMID:19191707 More... NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gtf2b general transcription factor IIB decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of GTF2B mRNA CTD PMID:12419474 NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
increases phosphorylation
ISO POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]; REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
4-hydroxy-2-nonenal results in increased expression of H2AX protein
[procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein
CTD PMID:22331492 PMID:34503147 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) decreases activity ISO 4-hydroxy-2-nonenal results in decreased activity of H6PD protein CTD PMID:20211231 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Haspin histone H3 associated protein kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HASPIN mRNA CTD PMID:19191707 NCBI chr10:57,747,731...57,750,518
Ensembl chr10:57,747,573...57,750,512
JBrowse link
G Hbegf heparin-binding EGF-like growth factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HBEGF mRNA CTD PMID:12419474 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hbp1 HMG-box transcription factor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HBP1 mRNA CTD PMID:19191707 NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HCK mRNA CTD PMID:19191707 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hdc histidine decarboxylase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HDC mRNA CTD PMID:19191707 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hells helicase, lymphoid specific decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HELLS mRNA CTD PMID:19191707 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HERC3 mRNA CTD PMID:19191707 NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HERC5 mRNA CTD PMID:19191707 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HGF mRNA CTD PMID:12419474 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HINT1 mRNA CTD PMID:12419474 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568
JBrowse link
G Hivep2 HIVEP zinc finger 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HIVEP2 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993
JBrowse link
G Hivep3 HIVEP zinc finger 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HIVEP3 mRNA CTD PMID:19191707 NCBI chr 5:133,325,327...133,727,797
Ensembl chr 5:133,658,052...133,727,795
JBrowse link
G Hlx H2.0-like homeobox decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HLX mRNA CTD PMID:19191707 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
JBrowse link
G Hmga1 high mobility group AT-hook 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HMGA1 mRNA CTD PMID:12419474 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HMGA2 mRNA CTD PMID:19191707 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal analog results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1; 4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA; 4-hydroxy-2-nonenal results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; methyl-beta-cyclodextrin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]
CTD PMID:18232660 PMID:19191707 PMID:20638469 PMID:23845594 PMID:24291486 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HNF4A mRNA CTD PMID:12419474 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HPRT1 mRNA CTD PMID:19191707 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSD17B11 mRNA CTD PMID:19191707 NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 affects binding EXP
ISO
4-hydroxy-2-nonenal binds to HSP90AA1 protein
4-hydroxy-2-nonenal analog binds to HSP90AA1
CTD PMID:18232660 PMID:21749116 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding EXP 4-hydroxy-2-nonenal binds to HSP90AB1 protein CTD PMID:21749116 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPA1A CTD PMID:18232660 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSPA1B mRNA CTD PMID:19191707 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPA1L CTD PMID:18232660 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HSPA2 mRNA CTD PMID:12419474 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa4l heat shock protein family A (Hsp70) member 4 like increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSPA4L mRNA CTD PMID:19191707 NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects binding
multiple interactions
increases expression
ISO
EXP
4-hydroxy-2-nonenal analog binds to HSPA5
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA]
4-hydroxy-2-nonenal results in increased expression of HSPA5 mRNA; 4-hydroxy-2-nonenal results in increased expression of HSPA5 protein
CTD PMID:18232660 PMID:24291486 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPA9 CTD PMID:18232660 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects binding ISO 4-hydroxy-2-nonenal analog binds to HSPD1 CTD PMID:18232660 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HSPH1 mRNA CTD PMID:19191707 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of HTATIP2 mRNA CTD PMID:19191707 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Hus1 HUS1 checkpoint clamp component decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of HUS1 mRNA CTD PMID:19191707 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ICAM1 mRNA CTD PMID:19191707 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ID1 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IDH1 mRNA CTD PMID:19191707 NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
JBrowse link
G Ier3 immediate early response 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IER3 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFI44L mRNA CTD PMID:19191707 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFIH1 mRNA CTD PMID:19191707 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFIT2 mRNA CTD PMID:19191707 NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFIT3 mRNA CTD PMID:19191707 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Ifitm2 interferon induced transmembrane protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFITM2 mRNA CTD PMID:19191707 NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 protein] CTD PMID:19627980 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions ISO [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein; [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IFNG protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IFNG protein] CTD PMID:18267128 PMID:33007382 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IGF1 mRNA CTD PMID:19191707 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IGF1R mRNA CTD PMID:12419474 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IKBKE mRNA CTD PMID:19191707 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Ikzf1 IKAROS family zinc finger 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IKZF1 mRNA CTD PMID:19191707 NCBI chr14:86,255,065...86,340,839
Ensembl chr14:86,255,065...86,342,416
JBrowse link
G Il10 interleukin 10 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL10 mRNA CTD PMID:19191707 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of IL10RA mRNA CTD PMID:19191707 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL12RB1 mRNA CTD PMID:12419474 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL13RA1 mRNA CTD PMID:19191707 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681
JBrowse link
G Il17a interleukin 17A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL17A mRNA CTD PMID:12419474 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL18 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL18RAP mRNA CTD PMID:19191707 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1B mRNA CTD PMID:19191707 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL1RN mRNA CTD PMID:19191707 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Trichloroethylene co-treated with 4-hydroxy-2-nonenal analog] results in increased expression of IL2 protein CTD PMID:18267128 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il27 interleukin 27 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL27 mRNA CTD PMID:19191707 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582
JBrowse link
G Il3 interleukin 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL3 mRNA CTD PMID:12419474 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il36a interleukin 36, alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL36A mRNA CTD PMID:19191707 NCBI chr 3:6,996,851...7,001,400
Ensembl chr 3:6,996,851...7,001,400
JBrowse link
G Il4r interleukin 4 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL4RA mRNA CTD PMID:19191707 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased expression of IL6 mRNA
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein; sulforaphane inhibits the reaction [[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of IL6 protein]
CTD PMID:19191707 PMID:33007382 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL6R mRNA CTD PMID:12419474 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Il7r interleukin 7 receptor decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of IL7R mRNA
4-hydroxy-2-nonenal results in increased expression of IL7R mRNA
CTD PMID:12419474 PMID:19191707 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Il9 interleukin 9 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IL9 mRNA CTD PMID:12419474 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895
JBrowse link
G Impact impact RWD domain protein decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of IMPACT mRNA
4-hydroxy-2-nonenal results in increased expression of IMPACT mRNA
CTD PMID:19191707 NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of INPPL1 mRNA CTD PMID:19191707 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Insig2 insulin induced gene 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of INSIG2 mRNA CTD PMID:19191707 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IRAK3 mRNA CTD PMID:19191707 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of IRF3 protein]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein] CTD PMID:19627980 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IRF7 mRNA CTD PMID:19191707 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irf8 interferon regulatory factor 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IRF8 mRNA CTD PMID:19191707 NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Irgm immunity-related GTPase M decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IRGM mRNA CTD PMID:19191707 NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ISG15 mRNA CTD PMID:19191707 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ISG20 mRNA CTD PMID:19191707 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNA CTD PMID:12419474 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITGA6 mRNA CTD PMID:12419474 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Itga7 integrin subunit alpha 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITGA7 mRNA CTD PMID:12419474 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450
JBrowse link
G Itgal integrin subunit alpha L decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITGAL mRNA CTD PMID:19191707 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732
JBrowse link
G Itgam integrin subunit alpha M decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITGAM mRNA CTD PMID:19191707 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb6 integrin subunit beta 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITGB6 mRNA CTD PMID:12419474 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671
JBrowse link
G Itsn1 intersectin 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ITSN1 mRNA CTD PMID:12419474 NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of JAK2 mRNA CTD PMID:19191707 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jdp2 Jun dimerization protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of JDP2 mRNA CTD PMID:19191707 NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
increases phosphorylation
affects response to substance
ISO
EXP
4-hydroxy-2-nonenal results in decreased expression of JUN mRNA
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]; Quercetin inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of JUN protein]
JUN protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]; 4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein; pyrazolanthrone inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUN protein]]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of and results in increased phosphorylation of JUN protein]
CTD PMID:9890986 PMID:11488593 PMID:12419474 PMID:16322078 PMID:16337876 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]] CTD PMID:9890986 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in decreased expression of JUND mRNA
4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]; FOSL1 protein affects the reaction [4-hydroxy-2-nonenal results in increased activity of [JUN protein binds to JUND protein binds to JUNB protein]]
CTD PMID:9890986 PMID:12419474 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kat8 lysine acetyltransferase 8 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of KAT8 mRNA CTD PMID:19191707 NCBI chr 1:182,524,355...182,536,638
Ensembl chr 1:182,515,327...182,536,633
JBrowse link
G Kdm6b lysine demethylase 6B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of KDM6B mRNA CTD PMID:19191707 NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794
JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of KIF11 mRNA CTD PMID:19191707 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif20b kinesin family member 20B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of KIF20B mRNA CTD PMID:19191707 NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
JBrowse link
G Kitlg KIT ligand increases expression ISO 4-hydroxy-2-nonenal results in increased expression of KITL mRNA CTD PMID:19191707 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
JBrowse link
G Klf7 KLF transcription factor 7 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of KLF7 mRNA CTD PMID:19191707 NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Klhl6 kelch-like family member 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of KLHL6 mRNA CTD PMID:19191707 NCBI chr11:80,970,917...81,010,593
Ensembl chr11:80,970,917...81,009,677
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of KPNA2 mRNA CTD PMID:19191707 NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 increases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in increased expression of LAMP1 mRNA; 4-hydroxy-2-nonenal results in increased expression of LAMP1 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]
CTD PMID:35550146 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G Lat linker for activation of T cells decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LAT mRNA CTD PMID:12419474 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
JBrowse link
G Lcat lecithin cholesterol acyltransferase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LCAT mRNA CTD PMID:12419474 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LCK mRNA CTD PMID:12419474 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lif LIF, interleukin 6 family cytokine decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LIF mRNA CTD PMID:19191707 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lipa lipase A, lysosomal acid type increases expression ISO 4-hydroxy-2-nonenal results in increased expression of LIPA mRNA CTD PMID:19191707 NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
JBrowse link
G Lipg lipase G, endothelial type decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LIPG mRNA CTD PMID:19191707 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of LPAR1 mRNA CTD PMID:19191707 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Lpin1 lipin 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of LPIN1 mRNA CTD PMID:19191707 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
JBrowse link
G Lrrc59 leucine rich repeat containing 59 affects binding ISO LRRC59 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533
JBrowse link
G Lrrfip2 LRR binding FLII interacting protein 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of LRRFIP2 mRNA CTD PMID:19191707 NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255
JBrowse link
G Ltb lymphotoxin beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LTB mRNA CTD PMID:19191707 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LY6E mRNA CTD PMID:19191707 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
JBrowse link
G Ly96 lymphocyte antigen 96 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of LY96 mRNA CTD PMID:19191707 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of LYN mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Maf1 MAF1 homolog, negative regulator of RNA polymerase III increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MAF1 mRNA CTD PMID:19191707 NCBI chr 7:108,075,173...108,078,252
Ensembl chr 7:108,075,189...108,078,249
JBrowse link
G Mafb MAF bZIP transcription factor B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MAFB mRNA CTD PMID:19191707 NCBI chr 3:148,998,111...149,000,031
Ensembl chr 3:148,998,122...149,000,031
JBrowse link
G Mafg MAF bZIP transcription factor G increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MAFG mRNA CTD PMID:19191707 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MAP1LC3B mRNA CTD PMID:19191707 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MAP2K5 mRNA CTD PMID:12419474 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MAP3K20 mRNA CTD PMID:19191707 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases activity
multiple interactions
increases phosphorylation
ISO
EXP
4-hydroxy-2-nonenal results in decreased activity of MAPK1 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK1 protein
4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK1 protein
CTD PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases expression
ISO 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; Acetylcysteine inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits the reaction [[4-hydroxy-2-nonenal co-treated with Hydrogen Peroxide] results in increased activity of MAPK14 protein]; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]
4-hydroxy-2-nonenal results in increased expression of MAPK14 mRNA
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK14 protein]
CTD PMID:12684028 PMID:16322078 PMID:19191707 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases activity
multiple interactions
increases phosphorylation
ISO
EXP
4-hydroxy-2-nonenal results in decreased activity of MAPK3 protein
4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; 4-hydroxy-2-nonenal results in increased activity of [MAPK1 protein co-treated with MAPK3 protein]; 4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK3 protein
4-hydroxy-2-nonenal results in increased activity of and results in increased phosphorylation of MAPK3 protein
CTD PMID:16322078 PMID:17263905 PMID:23845594 PMID:24291486 PMID:24423726 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity
increases phosphorylation
affects response to substance
multiple interactions
ISO 4-hydroxy-2-nonenal results in increased activity of MAPK8 protein
4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein
MAPK8 protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; GSTA4 protein inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]
4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein; Hydrogen Peroxide promotes the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]
CTD PMID:11488593 PMID:12684028 PMID:15064094 PMID:16322078 PMID:17263905 More... NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO 4-hydroxy-2-nonenal results in increased phosphorylation of MAPK9 protein CTD PMID:24825450 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Marcksl1 MARCKS-like 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MARCKSL1 mRNA CTD PMID:12419474 NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817
JBrowse link
G Mark3 microtubule affinity regulating kinase 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MARK3 mRNA CTD PMID:12419474 NCBI chr 6:130,626,612...130,716,245
Ensembl chr 6:130,627,482...130,716,647
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MCM4 mRNA CTD PMID:12419474 NCBI chr11:85,258,443...85,272,144
Ensembl chr11:85,258,443...85,272,144
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MCM6 mRNA CTD PMID:19191707 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
JBrowse link
G Metap1d methionyl aminopeptidase type 1D (mitochondrial) increases expression ISO 4-hydroxy-2-nonenal results in increased expression of METAP1D mRNA CTD PMID:19191707 NCBI chr 3:56,279,471...56,354,518
Ensembl chr 3:56,279,493...56,351,981
JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase subunit multiple interactions ISO METTL14 protein promotes the reaction [Doxorubicin results in increased abundance of 4-hydroxy-2-nonenal] CTD PMID:34648132 NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MITF mRNA CTD PMID:23489423 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MKI67 mRNA CTD PMID:19191707 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MKNK1 mRNA CTD PMID:19191707 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
JBrowse link
G Mlh1 mutL homolog 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MLH1 mRNA CTD PMID:12419474 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases activity
increases expression
ISO 4-hydroxy-2-nonenal results in increased activity of MMP1 protein
4-hydroxy-2-nonenal results in increased expression of MMP1 mRNA
CTD PMID:14672615 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
increases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in increased activity of MMP2 protein
4-hydroxy-2-nonenal results in increased expression of MMP2 mRNA
1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2]; 4-hydroxy-2-nonenal results in increased expression of and results in increased secretion of and results in increased activity of MMP2 protein; AKT1 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2 protein]
CTD PMID:14672615 PMID:18805481 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
increases activity
multiple interactions
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of MMP9 mRNA
4-hydroxy-2-nonenal results in increased activity of MMP9 protein
ALOX5 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; MK-886 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]; U 75302 inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP9 protein]
4-hydroxy-2-nonenal results in increased expression of MMP9 mRNA; 4-hydroxy-2-nonenal results in increased expression of MMP9 protein
CTD PMID:19191707 PMID:19837106 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mnda myeloid cell nuclear differentiation antigen decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of IFI16 mRNA; 4-hydroxy-2-nonenal results in decreased expression of IFI204 mRNA
4-hydroxy-2-nonenal results in decreased expression of MNDA mRNA
CTD PMID:12419474 PMID:19191707 NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201
JBrowse link
G Mocos molybdenum cofactor sulfurase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MOCOS mRNA CTD PMID:19191707 NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mov10 Mov10 RNA helicase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MOV10 mRNA CTD PMID:19191707 NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
JBrowse link
G Ms4a6a membrane spanning 4-domains A6A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MS4A6C mRNA CTD PMID:19191707 NCBI chr 1:208,401,465...208,414,831
Ensembl chr 1:208,401,466...208,414,758
JBrowse link
G Msh5 mutS homolog 5 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MSH5 mRNA CTD PMID:19191707 NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336
JBrowse link
G Mt2A metallothionein 2A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MT2 mRNA CTD PMID:19191707 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MTHFS mRNA CTD PMID:19191707 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089
JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:117,859,355...117,910,839
Ensembl chr 1:117,859,267...117,910,849
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MTOR mRNA CTD PMID:12419474 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mtss1 MTSS I-BAR domain containing 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MTSS1 mRNA CTD PMID:19191707 NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
JBrowse link
G Mutyh mutY DNA glycosylase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of MUTYH mRNA CTD PMID:19191707 NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146
JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MX1 mRNA CTD PMID:19191707 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Mxd1 max dimerization protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MXD1 mRNA CTD PMID:19191707 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MYBL2 mRNA CTD PMID:12419474 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MYC mRNA CTD PMID:12419474 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Mylk myosin light chain kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of MYLK mRNA CTD PMID:12419474 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Nab2 Ngfi-A binding protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NAB2 mRNA CTD PMID:19191707 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
JBrowse link
G Napb NSF attachment protein beta increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NAPB mRNA CTD PMID:19191707 NCBI chr 3:136,132,248...136,179,280
Ensembl chr 3:136,133,428...136,179,345
JBrowse link
G Nbn nibrin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NBN mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nck1 NCK adaptor protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NCK1 mRNA CTD PMID:12419474 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
G Ndc80 NDC80 kinetochore complex component decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NDC80 mRNA CTD PMID:19191707 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NECTIN1 mRNA CTD PMID:12419474 NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787
JBrowse link
G Neil3 nei-like DNA glycosylase 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NEIL3 mRNA CTD PMID:19191707 NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of NEK2 mRNA
4-hydroxy-2-nonenal results in increased expression of NEK2 mRNA
CTD PMID:19191707 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link
G Nek3 NIMA-related kinase 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NEK3 mRNA CTD PMID:19191707 NCBI chr16:69,867,020...69,892,477
Ensembl chr16:69,867,047...69,892,508
JBrowse link
G Nek6 NIMA-related kinase 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NEK6 mRNA CTD PMID:19191707 NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
JBrowse link
G Neo1 neogenin 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NEO1 mRNA CTD PMID:12419474 NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348
JBrowse link
G Neu1 neuraminidase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NEU1 mRNA CTD PMID:35550146 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NF2 mRNA CTD PMID:12419474 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Nfam1 NFAT activating protein with ITAM motif 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NFAM1 mRNA CTD PMID:19191707 NCBI chr 7:114,139,318...114,175,395
Ensembl chr 7:114,139,345...114,175,442
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NFATC1 mRNA CTD PMID:12419474 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NFE2L1 mRNA CTD PMID:12419474 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases activity
multiple interactions
affects response to substance
affects localization
increases expression
ISO
EXP
4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein
AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]
4-hydroxy-2-nonenal affects the localization of NFE2L2 protein
4-hydroxy-2-nonenal affects the localization of and results in increased activity of NFE2L2 protein; [GSTA4 protein mutant form results in decreased glutathionylation of 4-hydroxy-2-nonenal] which results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; NFE2L2 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of NFE2L2 protein]
4-hydroxy-2-nonenal results in increased expression of NFE2L2 protein
NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]
CTD PMID:16322078 PMID:19880816 PMID:24291486 PMID:24423726 PMID:24633890 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfic nuclear factor I/C increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NFIC mRNA CTD PMID:19191707 NCBI chr 7:8,278,210...8,309,936
Ensembl chr 7:8,253,361...8,309,936
JBrowse link
G Nfix nuclear factor I X decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NFIX mRNA CTD PMID:12419474 NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression
multiple interactions
ISO
EXP
4-hydroxy-2-nonenal results in decreased expression of NFKB1 mRNA
4-hydroxy-2-nonenal results in decreased activity of [NFKB1 protein binds to NFKB1 protein]; 4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein]
CTD PMID:11146106 PMID:12419474 PMID:19191707 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression
ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
4-hydroxy-2-nonenal results in increased expression of NFKBIA mRNA
CTD PMID:19191707 PMID:19627980 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbie NFKB inhibitor epsilon increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NFKBIE mRNA CTD PMID:19191707 NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437
JBrowse link
G Nfkbiz NFKB inhibitor zeta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NFKBIZ mRNA CTD PMID:19191707 NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
JBrowse link
G Nfrkb nuclear factor related to kappa B binding protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NFRKB mRNA CTD PMID:12419474 NCBI chr 8:29,831,802...29,863,360
Ensembl chr 8:29,831,812...29,863,359
JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NFX1 mRNA CTD PMID:12419474 NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912
JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NKIRAS1 mRNA CTD PMID:19191707 NCBI chr15:7,493,531...7,503,758
Ensembl chr15:7,493,531...7,503,854
JBrowse link
G Nlrc4 NLR family, CARD domain containing 4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NLRC4 mRNA CTD PMID:19191707 NCBI chr 6:20,991,785...21,018,254
Ensembl chr 6:20,995,266...21,018,248
JBrowse link
G Nlrp10 NLR family, pyrin domain containing 10 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NLRP10 mRNA CTD PMID:19191707 NCBI chr 1:162,922,806...162,930,363
Ensembl chr 1:162,922,806...162,930,363
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NLRP3 mRNA CTD PMID:19191707 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nmb neuromedin B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NMB mRNA CTD PMID:12419474 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NME2 mRNA CTD PMID:12419474 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NOS2 protein CTD PMID:20940037 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NOTCH1 mRNA CTD PMID:19191707 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA
4-hydroxy-2-nonenal results in increased expression of NQO1 mRNA; 4-hydroxy-2-nonenal results in increased expression of NQO1 protein
CTD PMID:24423726 PMID:29108775 PMID:30849339 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NR1D1 mRNA CTD PMID:19191707 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NR1D2 mRNA CTD PMID:19191707 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NR1I3 mRNA CTD PMID:12419474 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr2f6 nuclear receptor subfamily 2, group F, member 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NR2F6 mRNA CTD PMID:12419474 NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NR3C1 mRNA CTD PMID:19191707 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NR4A1 mRNA CTD PMID:19191707 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nrp1 neuropilin 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NRP1 mRNA CTD PMID:19191707 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Nsl1 NSL1 component of MIS12 kinetochore complex decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NSL1 mRNA CTD PMID:19191707 NCBI chr13:102,649,050...102,674,059
Ensembl chr13:102,649,058...102,674,054
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NUF2 mRNA CTD PMID:19191707 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
JBrowse link
G Nufip1 nuclear FMR1 interacting protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NUFIP1 mRNA CTD PMID:19191707 NCBI chr15:51,429,518...51,460,308
Ensembl chr15:51,429,549...51,460,310
JBrowse link
G Nup210 nucleoporin 210 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NUP210 mRNA CTD PMID:19191707 NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874
JBrowse link
G Nup85 nucleoporin 85 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of NUP85 mRNA CTD PMID:19191707 NCBI chr10:100,806,482...100,825,029
Ensembl chr10:100,806,437...100,825,043
JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of NUSAP1 mRNA CTD PMID:19191707 NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of OAS3 mRNA CTD PMID:19191707 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
JBrowse link
G Olr1271 olfactory receptor 1271 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of OR8D1 mRNA; 4-hydroxy-2-nonenal results in increased expression of OR8D1B mRNA CTD PMID:19191707 NCBI chr 8:39,127,409...39,131,889
Ensembl chr 8:39,127,352...39,131,900
JBrowse link
G Osm oncostatin M decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of OSM mRNA CTD PMID:19191707 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 multiple interactions ISO [[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal CTD PMID:35234341 NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
JBrowse link
G P2rx5 purinergic receptor P2X 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of P2RX5 mRNA CTD PMID:12419474 NCBI chr10:57,777,737...57,789,426
Ensembl chr10:57,777,819...57,789,423
JBrowse link
G P2ry2 purinergic receptor P2Y2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of P2RY2 mRNA CTD PMID:19191707 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta affects metabolic processing EXP 4-hydroxy-2-nonenal affects the metabolism of P4HB protein CTD PMID:16097806 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Pa2g4 proliferation-associated 2G4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PA2G4 mRNA CTD PMID:19191707 NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PAIP1 mRNA CTD PMID:12419474 NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation ISO 4-hydroxy-2-nonenal results in increased degradation of PARP1 protein CTD PMID:11488593 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp12 poly (ADP-ribose) polymerase family, member 12 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PARP12 mRNA CTD PMID:19191707 NCBI chr 4:67,826,548...67,885,356
Ensembl chr 4:67,839,237...67,883,685
JBrowse link
G Pbk PDZ binding kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PBK mRNA CTD PMID:19191707 NCBI chr15:40,022,873...40,034,014
Ensembl chr15:40,023,002...40,034,014
JBrowse link
G Pcgf5 polycomb group ring finger 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PCGF5 mRNA CTD PMID:19191707 NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PCNA mRNA CTD PMID:19191707 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PCSK2 mRNA CTD PMID:12419474 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pcyox1 prenylcysteine oxidase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PCYOX1 mRNA CTD PMID:19191707 NCBI chr 4:118,832,114...118,842,951
Ensembl chr 4:118,830,638...118,842,951
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PDCD4 mRNA CTD PMID:19191707 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdgfb platelet derived growth factor subunit B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 affects binding ISO 4-hydroxy-2-nonenal analog binds to PDIA3 CTD PMID:18232660 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PDSS1 mRNA CTD PMID:19191707 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730
JBrowse link
G Pdyn prodynorphin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PDYN mRNA CTD PMID:12419474 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334
JBrowse link
G Penk proenkephalin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PENK mRNA CTD PMID:19191707 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Per1 period circadian regulator 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PER1 mRNA CTD PMID:19191707 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pex7 peroxisomal biogenesis factor 7 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PEX7 mRNA CTD PMID:19191707 NCBI chr 1:14,582,698...14,646,686
Ensembl chr 1:14,582,699...14,646,748
JBrowse link
G Pgd phosphogluconate dehydrogenase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PGD mRNA CTD PMID:19191707 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Pglyrp3 peptidoglycan recognition protein 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PGLYRP3 mRNA CTD PMID:19191707 NCBI chr 2:177,479,693...177,490,769
Ensembl chr 2:177,477,407...177,490,736
Ensembl chr 2:177,477,407...177,490,736
JBrowse link
G Pgm2l1 phosphoglucomutase 2-like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PGM2L1 mRNA CTD PMID:19191707 NCBI chr 1:154,571,410...154,620,901
Ensembl chr 1:154,571,766...154,620,902
JBrowse link
G Pgs1 phosphatidylglycerophosphate synthase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PGS1 mRNA CTD PMID:19191707 NCBI chr10:103,214,635...103,250,254
Ensembl chr10:103,214,646...103,250,254
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PHB1 mRNA CTD PMID:12419474 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Phf11 PHD finger protein 11 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PHF11 mRNA CTD PMID:19191707 NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009
JBrowse link
G Phf21a PHD finger protein 21A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PHF21A mRNA CTD PMID:19191707 NCBI chr 3:78,158,760...78,331,903
Ensembl chr 3:78,194,549...78,331,865
JBrowse link
G Phgdh phosphoglycerate dehydrogenase affects binding ISO PHGDH protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PIK3CB mRNA CTD PMID:19191707 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PIK3CD mRNA CTD PMID:19191707 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PIK3R2 mRNA CTD PMID:12419474 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PILRA mRNA CTD PMID:19191707 NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 affects binding
increases response to substance
ISO 4-hydroxy-2-nonenal binds to PIN1 protein
PIN1 protein results in increased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:23231502 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Pkm pyruvate kinase M1/2 affects binding
multiple interactions
ISO 4-hydroxy-2-nonenal analog binds to PKM protein
4-hydroxy-2-nonenal binds to and results in decreased activity of PKM protein; 4-hydroxy-2-nonenal promotes the reaction [PKM protein binds to PKM protein]
CTD PMID:27978618 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
G Pla2g7 phospholipase A2 group VII increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PLA2G7 mRNA CTD PMID:19191707 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476
JBrowse link
G Plagl2 PLAG1 like zinc finger 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PLAGL2 mRNA CTD PMID:19191707 NCBI chr 3:141,695,322...141,708,516
Ensembl chr 3:141,695,322...141,708,503
JBrowse link
G Pld2 phospholipase D2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PLD2 mRNA CTD PMID:19191707 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:88,313,837...88,366,182
Ensembl chr10:88,314,651...88,362,412
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of PLEKHO1 mRNA
4-hydroxy-2-nonenal results in increased expression of PLEKHO1 mRNA
CTD PMID:19191707 NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785
JBrowse link
G Plk1 polo-like kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PLK1 mRNA CTD PMID:19191707 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Polb DNA polymerase beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of POLB mRNA CTD PMID:12419474 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Pold1 DNA polymerase delta 1, catalytic subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of POLD1 mRNA CTD PMID:12419474 NCBI chr 1:95,025,462...95,041,559
Ensembl chr 1:95,025,499...95,036,465
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit increases expression ISO 4-hydroxy-2-nonenal results in increased expression of POLE mRNA CTD PMID:19191707 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
JBrowse link
G Polh DNA polymerase eta multiple interactions
affects response to substance
ISO POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
POLH protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD PMID:22331492 NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
JBrowse link
G Polk DNA polymerase kappa multiple interactions ISO POLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] CTD PMID:22331492 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
JBrowse link
G Poll DNA polymerase lambda affects response to substance
multiple interactions
ISO POLL protein affects the susceptibility to 4-hydroxy-2-nonenal
POLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
CTD PMID:22331492 NCBI chr 1:244,400,202...244,408,762
Ensembl chr 1:244,400,204...244,408,662
JBrowse link
G Polq DNA polymerase theta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of POLQ mRNA CTD PMID:19191707 NCBI chr11:63,673,796...63,775,905
Ensembl chr11:63,673,816...63,775,878
JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases activity
ISO 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; 4-hydroxy-2-nonenal inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]
4-hydroxy-2-nonenal results in decreased activity of PON1 protein
CTD PMID:15375178 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pou2f2 POU class 2 homeobox 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of POU2F2 mRNA CTD PMID:19191707 NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PPARG protein CTD PMID:27417252 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppid peptidylprolyl isomerase D increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PPID mRNA CTD PMID:19191707 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221
JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PPIL1 mRNA CTD PMID:19191707 NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PPP1CA mRNA CTD PMID:12419474 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of PPP1R15A mRNA]
CTD PMID:24291486 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PPP1R15B mRNA CTD PMID:19191707 NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA CTD PMID:12419474 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prdm1 PR/SET domain 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PRDM1 mRNA CTD PMID:12419474 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prdx1 peroxiredoxin 1 affects binding
increases expression
ISO 4-hydroxy-2-nonenal analog binds to PRDX1
4-hydroxy-2-nonenal results in increased expression of PRDX1 mRNA
CTD PMID:18232660 PMID:19191707 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PRKDC mRNA CTD PMID:12419474 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Procr protein C receptor increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PROCR mRNA CTD PMID:19191707 NCBI chr 3:144,254,596...144,258,863
Ensembl chr 3:144,254,380...144,258,903
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PSMB10 mRNA CTD PMID:19191707 NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
JBrowse link
G Psmc3ip PSMC3 interacting protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PSMC3IP mRNA CTD PMID:19191707 NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PSMD12 mRNA CTD PMID:19191707 NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PTGER4 mRNA CTD PMID:19191707 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PTGES mRNA CTD PMID:19191707 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgr1 prostaglandin reductase 1 multiple interactions
decreases response to substance
EXP [PTGR1 protein co-treated with NADP] affects the reduction of 4-hydroxy-2-nonenal
PTGR1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal
CTD PMID:11524419 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PTK2 mRNA CTD PMID:12419474 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PTPN1 mRNA CTD PMID:12419474 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of PTPRA mRNA CTD PMID:19191707 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728
JBrowse link
G Pxk PX domain containing serine/threonine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of PXK mRNA CTD PMID:19191707 NCBI chr15:16,759,857...16,828,452
Ensembl chr15:16,759,862...16,828,444
JBrowse link
G Rab11a RAB11a, member RAS oncogene family increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RAB11A mRNA CTD PMID:19191707 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RABGEF1 mRNA CTD PMID:19191707 NCBI chr12:26,459,190...26,503,790
Ensembl chr12:26,460,175...26,503,744
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RAD23A mRNA CTD PMID:19191707 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
JBrowse link
G Rad51 RAD51 recombinase decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of RAD51 mRNA
4-hydroxy-2-nonenal results in increased expression of RAD51 mRNA
CTD PMID:19191707 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rad54l RAD54 like decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RAD54L mRNA CTD PMID:19191707 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070
JBrowse link
G Raet1e retinoic acid early transcript 1E increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RAET1E mRNA CTD PMID:19191707 NCBI chr 1:1,662,665...1,664,609
Ensembl chr 1:1,807,644...1,812,755
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RAF1 mRNA CTD PMID:19191707 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ralbp1 ralA binding protein 1 decreases response to substance ISO RALBP1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal CTD PMID:15950949 NCBI chr 9:105,456,425...105,493,235
Ensembl chr 9:105,456,425...105,492,707
JBrowse link
G Ralgds ral guanine nucleotide dissociation stimulator decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RALGDS mRNA CTD PMID:12419474 NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059
JBrowse link
G Ralgps1 Ral GEF with PH domain and SH3 binding motif 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RALGPS1 mRNA CTD PMID:19191707 NCBI chr 3:16,433,323...16,670,276
Ensembl chr 3:16,433,742...16,669,972
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RARA mRNA CTD PMID:19191707 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Rarb retinoic acid receptor, beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RARB mRNA CTD PMID:12419474 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rasgef1b RasGEF domain family, member 1B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RASGEF1B mRNA CTD PMID:19191707 NCBI chr14:9,859,512...10,380,044
Ensembl chr14:9,860,247...10,379,741
JBrowse link
G Rasgrp3 RAS guanyl releasing protein 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RASGRP3 mRNA CTD PMID:19191707 NCBI chr 6:19,895,361...19,993,945
Ensembl chr 6:19,895,390...19,958,578
JBrowse link
G Rassf2 Ras association domain family member 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RASSF2 mRNA CTD PMID:19191707 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Rassf8 Ras association domain family member 8 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RASSF8 mRNA CTD PMID:19191707 NCBI chr 4:178,716,110...178,798,042
Ensembl chr 4:178,719,992...178,796,690
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
multiple interactions
ISO 4-hydroxy-2-nonenal results in decreased phosphorylation of RB1 protein
[[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased expression of RB1 protein modified form
CTD PMID:15607904 PMID:33007382 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RBL1 mRNA CTD PMID:19191707 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RBL2 mRNA CTD PMID:12419474 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of REL mRNA CTD PMID:12419474 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 4-hydroxy-2-nonenal results in decreased activity of [RELA protein binds to NFKB1 protein] CTD PMID:11146106 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rev1 REV1, DNA directed polymerase multiple interactions
affects response to substance
ISO REV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
REV1 protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD PMID:22331492 NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576
JBrowse link
G Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit multiple interactions
affects response to substance
ISO REV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein]
REV3L protein affects the susceptibility to 4-hydroxy-2-nonenal
CTD PMID:22331492 NCBI chr20:43,131,841...43,290,102
Ensembl chr20:43,132,363...43,290,099
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RFFL mRNA CTD PMID:19191707 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G Rgs1 regulator of G-protein signaling 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RGS1 mRNA CTD PMID:19191707 NCBI chr13:56,018,546...56,022,889
Ensembl chr13:56,018,554...56,022,984
JBrowse link
G Rig1 RNA sensor RIG-1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RIGI mRNA CTD PMID:19191707 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Riok3 RIO kinase 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RIOK3 mRNA CTD PMID:19191707 NCBI chr18:3,327,776...3,353,350
Ensembl chr18:3,327,776...3,353,343
JBrowse link
G Rit1 Ras-like without CAAX 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RIT1 mRNA CTD PMID:19191707 NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455
JBrowse link
G Rnd1 Rho family GTPase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RND1 mRNA CTD PMID:19191707 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rnf128 ring finger protein 128 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RNF128 mRNA CTD PMID:19191707 NCBI chr  X:103,183,643...103,298,431
Ensembl chr  X:103,183,831...103,298,423
JBrowse link
G Rnf167 ring finger protein 167 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RNF167 mRNA CTD PMID:19191707 NCBI chr10:55,360,603...55,364,927
Ensembl chr10:55,360,543...55,364,927
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RNF19B mRNA CTD PMID:19191707 NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380
JBrowse link
G Rpp38 ribonuclease P/MRP subunit p38 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RPP38 mRNA CTD PMID:19191707 NCBI chr17:74,914,066...74,917,742
Ensembl chr17:74,908,932...74,927,431
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RPS6KA2 mRNA CTD PMID:12419474 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation EXP 4-hydroxy-2-nonenal results in increased phosphorylation of RPS6KB1 protein CTD PMID:19289642 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RSAD2 mRNA CTD PMID:19191707 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE16 RT1 class I, locus CE16 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of RXRA mRNA CTD PMID:19191707 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Rxrb retinoid X receptor beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of RXRB mRNA CTD PMID:12419474 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of S1PR2 mRNA CTD PMID:19191707 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G Samhd1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 affects binding ISO SAMHD1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 3:145,761,549...145,794,420
Ensembl chr 3:145,761,558...145,794,386
JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SAMSN1 mRNA CTD PMID:19191707 NCBI chr11:14,484,523...14,534,900
Ensembl chr11:14,483,893...14,534,900
JBrowse link
G Sass6 SAS-6 centriolar assembly protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SASS6 mRNA CTD PMID:19191707 NCBI chr 2:204,546,660...204,578,930
Ensembl chr 2:204,546,660...204,578,927
JBrowse link
G Satb1 SATB homeobox 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SATB1 mRNA CTD PMID:12419474 NCBI chr 9:4,677,817...4,773,061
Ensembl chr 9:4,680,920...4,753,251
JBrowse link
G Sbno2 strawberry notch homolog 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SBNO2 mRNA CTD PMID:19191707 NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
affects binding
ISO Tobacco Smoke Pollution promotes the reaction [4-hydroxy-2-nonenal binds to SCARB1 protein] CTD PMID:22442701 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SELENBP1 mRNA CTD PMID:12419474 NCBI chr 2:182,494,004...182,504,594
Ensembl chr 2:182,493,978...182,504,594
JBrowse link
G Serbp1 Serpine1 mRNA binding protein 1 affects binding ISO SERBP1 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813
JBrowse link
G Serpinb5 serpin family B member 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SERPINB5 mRNA CTD PMID:12419474 NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
JBrowse link
G Serpinb9 serpin family B member 9 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SERPINB9 mRNA CTD PMID:19191707 NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230
JBrowse link
G Serpini1 serpin family I member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SERPINI1 mRNA CTD PMID:12419474 NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135
JBrowse link
G Sesn2 sestrin 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SESN2 mRNA CTD PMID:19191707 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SGK1 mRNA CTD PMID:19191707 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgo1 shugoshin 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SGO1 mRNA CTD PMID:19191707 NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805
JBrowse link
G Sgo2 shugoshin 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SGO2 mRNA CTD PMID:19191707 NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SGPL1 mRNA CTD PMID:19191707 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084
JBrowse link
G Shoc2 SHOC2 leucine-rich repeat scaffold protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SHOC2 mRNA CTD PMID:12419474 NCBI chr 1:252,958,939...253,048,820
Ensembl chr 1:252,959,723...253,047,337
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO SIRT1 protein inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of 4-hydroxy-2-nonenal] CTD PMID:24633890 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO 4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein CTD PMID:21449565 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
JBrowse link
G Slc25a27 solute carrier family 25, member 27 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SLC25A27 mRNA CTD PMID:20385226 NCBI chr 9:17,306,898...17,333,942
Ensembl chr 9:17,307,023...17,332,731
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO [APC protein mutant form results in increased expression of SLC7A11 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal
[[BGN mRNA alternative form binds to OTUB1 protein] which binds to and results in decreased ubiquitination of and results in increased stability of SLC7A11 protein] which results in decreased abundance of 4-hydroxy-2-nonenal
CTD PMID:21967605 PMID:35234341 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slc7a2 solute carrier family 7 member 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SLC7A2 mRNA CTD PMID:19191707 NCBI chr16:51,417,478...51,470,784
Ensembl chr16:51,417,493...51,470,784
JBrowse link
G Smad1 SMAD family member 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SMAD1 mRNA CTD PMID:12419474 NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
JBrowse link
G Snapc5 small nuclear RNA activating complex, polypeptide 5 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SNAPC5 mRNA CTD PMID:19191707 NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SOCS3 mRNA CTD PMID:19191707 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod2 superoxide dismutase 2 affects binding
increases abundance
multiple interactions
decreases abundance
increases expression
ISO 4-hydroxy-2-nonenal binds to SOD2 protein
SOD2 gene mutant form results in increased abundance of 4-hydroxy-2-nonenal
SOD2 protein inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased abundance of 4-hydroxy-2-nonenal]
SOD2 protein results in decreased abundance of 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal results in increased expression of SOD2 mRNA
CTD PMID:11507057 PMID:19191707 PMID:19374891 PMID:23199288 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sp100 SP100 nuclear antigen decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SP100 mRNA CTD PMID:19191707 NCBI chr 9:86,310,990...86,377,036
Ensembl chr 9:86,311,032...86,377,034
JBrowse link
G Sp110 SP110 nuclear body protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SP110 mRNA CTD PMID:19191707 NCBI chr 9:86,200,503...86,225,355
Ensembl chr 9:86,200,503...86,222,670
JBrowse link
G Sp2 Sp2 transcription factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SP2 mRNA CTD PMID:12419474 NCBI chr10:81,940,580...81,970,040
Ensembl chr10:81,940,587...81,970,548
JBrowse link
G Spa17 sperm autoantigenic protein 17 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SPA17 mRNA CTD PMID:19191707 NCBI chr 8:37,307,432...37,318,519
Ensembl chr 8:37,307,557...37,318,639
JBrowse link
G Spag5 sperm associated antigen 5 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SPAG5 mRNA CTD PMID:19191707 NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SPRY1 mRNA CTD PMID:19191707 NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SPRY2 mRNA CTD PMID:12419474 NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions
ISO 4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]
CTD PMID:19191707 PMID:35550146 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SRC mRNA CTD PMID:19191707 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srp9 signal recognition particle 9 affects binding ISO SRP9 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720
JBrowse link
G Srpk2 SRSF protein kinase 2 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SRPK2 mRNA CTD PMID:19191707 NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SRXN1 mRNA CTD PMID:19191707 PMID:22003191 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Ssbp3 single stranded DNA binding protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SSBP3 mRNA CTD PMID:19191707 NCBI chr 5:121,691,370...121,828,035
Ensembl chr 5:121,691,393...121,827,992
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of STAT1 mRNA CTD PMID:19191707 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of STAT3 mRNA CTD PMID:19191707 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of STAT5A mRNA CTD PMID:19191707 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat6 signal transducer and activator of transcription 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of STAT6 mRNA CTD PMID:12419474 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Stk11 serine/threonine kinase 11 decreases activity
decreases expression
multiple interactions
affects binding
EXP 4-hydroxy-2-nonenal results in decreased activity of STK11 protein
4-hydroxy-2-nonenal results in decreased expression of STK11 protein; 4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form
resveratrol inhibits the reaction [4-hydroxy-2-nonenal binds to STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased activity of STK11 protein]; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of STK11 protein modified form]
CTD PMID:19289642 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Stk17b serine/threonine kinase 17b decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of STK17B mRNA CTD PMID:19191707 NCBI chr 9:55,307,485...55,338,085
Ensembl chr 9:55,307,668...55,338,031
JBrowse link
G Stk3 serine/threonine kinase 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of STK3 mRNA CTD PMID:19191707 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stmn1 stathmin 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of STMN1 mRNA CTD PMID:19191707 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Stradb STE20 related adaptor beta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of STRADB mRNA CTD PMID:19191707 NCBI chr 9:60,414,182...60,433,084
Ensembl chr 9:60,414,182...60,433,084
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SUCLG1 mRNA CTD PMID:19191707 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Sumo3 small ubiquitin-like modifier 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SUMO3 mRNA CTD PMID:19191707 NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877
Ensembl chr20:11,007,148...11,020,877
JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SUV39H1 mRNA CTD PMID:19191707 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982
JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of SUV39H1 mRNA CTD PMID:19191707 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Syp synaptophysin decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of SYP mRNA CTD PMID:12419474 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP 4-hydroxy-2-nonenal results in increased secretion of TAC1 protein CTD PMID:17684094 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of TACC3 mRNA
4-hydroxy-2-nonenal results in increased expression of TACC3 mRNA
CTD PMID:19191707 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219
JBrowse link
G Tada3 transcriptional adaptor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TADA3 mRNA CTD PMID:12419474 NCBI chr 4:146,510,213...146,521,975
Ensembl chr 4:146,510,246...146,521,590
JBrowse link
G Tank TRAF family member-associated NFKB activator decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TANK mRNA CTD PMID:12419474 NCBI chr 3:46,114,230...46,190,270
Ensembl chr 3:46,114,274...46,190,264
JBrowse link
G Tbc1d12 TBC1 domain family, member 12 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TBC1D12 mRNA CTD PMID:19191707 NCBI chr 1:236,603,597...236,685,859
Ensembl chr 1:236,603,607...236,685,859
JBrowse link
G Tbc1d31 TBC1 domain family, member 31 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TBC1D31 mRNA CTD PMID:19191707 NCBI chr 7:89,427,354...89,506,894
Ensembl chr 7:89,426,780...89,506,894
JBrowse link
G Tbc1d8b TBC1 domain family member 8B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TBC1D8B mRNA CTD PMID:19191707 NCBI chr  X:103,319,181...103,407,137
Ensembl chr  X:103,319,340...103,407,133
JBrowse link
G Tbl1xr1 TBL1X/Y related 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TBL1XR1 mRNA CTD PMID:19191707 NCBI chr 2:104,788,950...104,929,055
Ensembl chr 2:104,801,721...104,929,055
JBrowse link
G Tcf3 transcription factor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TCF3 mRNA CTD PMID:12419474 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314
JBrowse link
G Terf1 telomeric repeat binding factor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TERF1 mRNA CTD PMID:12419474 NCBI chr 5:3,443,103...3,472,377
Ensembl chr 5:3,443,106...3,472,340
JBrowse link
G Tfdp2 transcription factor Dp-2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TFDP2 mRNA CTD PMID:12419474 NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682
JBrowse link
G Tfeb transcription factor EB multiple interactions
affects response to substance
affects localization
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; 4-hydroxy-2-nonenal results in decreased phosphorylation of and affects the localization of TFEB protein; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal affects the localization of TFEB protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of CTSD mRNA]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of LAMP1 protein]; TFEB protein affects the reaction [4-hydroxy-2-nonenal results in increased expression of SQSTM1 mRNA]
TFEB protein affects the susceptibility to 4-hydroxy-2-nonenal
4-hydroxy-2-nonenal affects the localization of TFEB protein; 4-hydroxy-2-nonenal affects the localization of TFEB protein mutant form
CTD PMID:35550146 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TGFB1 mRNA CTD PMID:19191707 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TGFBR1 mRNA CTD PMID:19191707 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of THRA mRNA CTD PMID:19191707 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of TIMP1 mRNA
4-hydroxy-2-nonenal results in decreased expression of TIMP1 mRNA
CTD PMID:14672615 PMID:19191707 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TIPARP mRNA CTD PMID:19191707 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Tjp1 tight junction protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TJP1 mRNA CTD PMID:12419474 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
decreases activity
ISO 4-hydroxy-2-nonenal inhibits the reaction [TLR4 protein binds to TLR4 protein]
4-hydroxy-2-nonenal results in decreased activity of TLR4 protein
4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]
CTD PMID:19627980 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; [[ALB protein binds to 4-hydroxy-2-nonenal] which results in increased susceptibility to Trichloroethylene] which results in increased secretion of TNF protein
4-hydroxy-2-nonenal results in increased expression of TNF mRNA
CTD PMID:19191707 PMID:19627980 PMID:33007382 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TNFAIP2 mRNA CTD PMID:12419474 NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TNFAIP3 mRNA CTD PMID:19191707 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of TNFAIP8 mRNA
4-hydroxy-2-nonenal results in increased expression of TNFAIP8 mRNA
CTD PMID:19191707 NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TNFRSF10B mRNA CTD PMID:19191707 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TNFRSF1A mRNA CTD PMID:12419474 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Top1 DNA topoisomerase I decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TOP1 mRNA CTD PMID:12419474 NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression
increases expression
ISO 4-hydroxy-2-nonenal results in decreased expression of TOP2A mRNA
4-hydroxy-2-nonenal results in increased expression of TOP2A mRNA
CTD PMID:12419474 PMID:19191707 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Tp53 tumor protein p53 increases expression
increases mutagenesis
affects abundance
ISO 4-hydroxy-2-nonenal results in increased expression of TP53 mRNA; 4-hydroxy-2-nonenal results in increased expression of TP53 protein
4-hydroxy-2-nonenal results in increased mutagenesis of TP53 gene
TRP53 protein affects the abundance of 4-hydroxy-2-nonenal
CTD PMID:11050162 PMID:15607904 PMID:22229939 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions ISO [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] affects the expression of TP53BP1 protein CTD PMID:34503147 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TRP53INP1 mRNA CTD PMID:19191707 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
JBrowse link
G Tp63 tumor protein p63 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TP63 protein CTD PMID:15607904 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tp73 tumor protein p73 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TP73 protein CTD PMID:15607904 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects binding ISO 4-hydroxy-2-nonenal binds to TPI1 protein CTD PMID:19374891 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Traf3 Tnf receptor-associated factor 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TRAF3 mRNA CTD PMID:19191707 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TRAF3IP2 mRNA CTD PMID:19191707 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions
EXP 4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA
4-phenylbutylamine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of TRIB3 mRNA]
CTD PMID:24291486 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim24 tripartite motif-containing 24 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TRIM24 mRNA CTD PMID:12419474 NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression
decreases expression
ISO 4-hydroxy-2-nonenal results in increased expression of TRIP13 mRNA
4-hydroxy-2-nonenal results in decreased expression of TRIP13 mRNA
CTD PMID:19191707 NCBI chr 1:29,357,093...29,402,078
Ensembl chr 1:29,357,130...29,402,074
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions
increases activity
ISO
EXP
Ruthenium Red inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]; TRPA1 gene mutant form inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [4-hydroxy-2-nonenal results in increased activity of TRPA1 protein]
CTD PMID:17684094 PMID:21689654 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TRPV4 mRNA CTD PMID:19191707 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Tsc1 TSC complex subunit 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TSC1 mRNA CTD PMID:19191707 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674
JBrowse link
G Tsc2 TSC complex subunit 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TSC2 mRNA CTD PMID:12419474 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TSC22D3 mRNA CTD PMID:19191707 NCBI chr  X:104,217,898...104,277,886
Ensembl chr  X:104,217,925...104,276,861
JBrowse link
G Tsg101 tumor susceptibility 101 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TSG101 mRNA CTD PMID:12419474 NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554
JBrowse link
G Tspan31 tetraspanin 31 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TSPAN31 mRNA CTD PMID:12419474 NCBI chr 7:62,889,552...62,892,428
Ensembl chr 7:62,889,552...62,898,388
JBrowse link
G Tspyl2 TSPY-like 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TSPYL2 mRNA CTD PMID:19191707 NCBI chr  X:21,439,478...21,445,208
Ensembl chr  X:21,439,478...21,445,089
JBrowse link
G Tuba1b tubulin, alpha 1B affects binding ISO TUBA1B protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:76,709,617...76,714,327
Ensembl chr 9:76,709,614...76,713,918
JBrowse link
G Txn1 thioredoxin 1 decreases activity
affects metabolic processing
ISO 4-hydroxy-2-nonenal results in decreased activity of TXN protein
4-hydroxy-2-nonenal affects the metabolism of TXN protein
CTD PMID:17982132 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of TXNRD1 mRNA CTD PMID:19191707 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Tyr tyrosinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of TYR mRNA CTD PMID:23489423 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO 4-hydroxy-2-nonenal results in increased activity of and results in increased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636
JBrowse link
G Ube2a ubiquitin-conjugating enzyme E2A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of UBE2A mRNA CTD PMID:12419474 NCBI chr  X:116,114,339...116,125,076
Ensembl chr  X:116,113,875...116,125,070
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of UBE2C mRNA CTD PMID:19191707 NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of UBE2D3 mRNA CTD PMID:19191707 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:223,868,730...223,898,081
JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I increases expression ISO 4-hydroxy-2-nonenal results in increased expression of UBE2I mRNA CTD PMID:19191707 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:69,701,618...69,702,443
Ensembl chr10:69,701,618...69,702,443
JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of UBE2L6 mRNA CTD PMID:19191707 NCBI chr 3:69,873,025...69,888,042
Ensembl chr 3:69,873,424...69,888,048
JBrowse link
G Ube2t ubiquitin-conjugating enzyme E2T increases expression ISO 4-hydroxy-2-nonenal results in increased expression of UBE2T mRNA CTD PMID:19191707 NCBI chr13:46,403,352...46,413,854
Ensembl chr13:46,403,375...46,414,835
JBrowse link
G Ube4b ubiquitination factor E4B increases expression ISO 4-hydroxy-2-nonenal results in increased expression of UBE4B mRNA CTD PMID:19191707 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509
JBrowse link
G Uchl1 ubiquitin C-terminal hydrolase L1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of UCHL1 mRNA CTD PMID:19191707 NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of UHRF1 mRNA CTD PMID:19191707 NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ULK1 mRNA CTD PMID:19191707 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Usf2 upstream transcription factor 2, c-fos interacting decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of USF2 mRNA CTD PMID:19191707 NCBI chr 1:86,174,703...86,185,942
Ensembl chr 1:86,174,703...86,185,617
JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of USP18 mRNA CTD PMID:19191707 NCBI chr 4:154,471,634...154,499,154
Ensembl chr 4:154,471,592...154,499,144
JBrowse link
G Usp37 ubiquitin specific peptidase 37 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of USP37 mRNA CTD PMID:19191707 NCBI chr 9:76,018,863...76,118,732
Ensembl chr 9:76,018,991...76,084,044
JBrowse link
G Uvrag UV radiation resistance associated decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of UVRAG mRNA CTD PMID:19191707 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
JBrowse link
G Vdac2 voltage-dependent anion channel 2 affects binding ISO VDAC2 protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of VEGFA mRNA CTD PMID:19191707 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vim vimentin affects binding ISO VIM protein binds to 4-hydroxy-2-nonenal CTD PMID:20043646 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt6 Wnt family member 6 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of WNT6 mRNA CTD PMID:19191707 NCBI chr 9:76,329,882...76,343,523
Ensembl chr 9:76,329,882...76,343,523
JBrowse link
G Wsb2 WD repeat and SOCS box-containing 2 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of WSB2 mRNA CTD PMID:19191707 NCBI chr12:39,217,645...39,238,634
Ensembl chr12:39,217,648...39,238,640
JBrowse link
G Xaf1 XIAP associated factor 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of XAF1 mRNA CTD PMID:19191707 NCBI chr10:56,917,378...56,929,791
Ensembl chr10:56,917,121...56,929,770
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing EXP 4-hydroxy-2-nonenal results in increased splicing of XBP1 mRNA CTD PMID:24291486 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xdh xanthine dehydrogenase increases expression ISO 4-hydroxy-2-nonenal results in increased expression of XDH mRNA CTD PMID:19191707 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of XPC mRNA CTD PMID:12419474 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
JBrowse link
G Ybx3 Y box binding protein 3 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of YBX3 mRNA CTD PMID:12419474 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of YES1 mRNA CTD PMID:12419474 NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of YWHAH mRNA CTD PMID:12419474 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
G Zbp1 Z-DNA binding protein 1 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ZBP1 mRNA CTD PMID:19191707 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:161,993,351...162,003,870
JBrowse link
G Zbtb20 zinc finger and BTB domain containing 20 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ZBTB20 mRNA CTD PMID:19191707 NCBI chr11:57,052,129...57,791,214
Ensembl chr11:57,072,880...57,510,210
JBrowse link
G Zbtb7c zinc finger and BTB domain containing 7C increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ZBTB7C mRNA CTD PMID:19191707 NCBI chr18:69,441,616...69,765,744
Ensembl chr18:69,441,616...69,765,297
JBrowse link
G Zdhhc18 zinc finger DHHC-type palmitoyltransferase 18 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ZDHHC18 mRNA CTD PMID:19191707 NCBI chr 5:145,821,534...145,859,989
Ensembl chr 5:145,831,446...145,859,993
JBrowse link
G Zfp36 zinc finger protein 36 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ZFP36 mRNA CTD PMID:12419474 PMID:19191707 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfp367 zinc finger protein 367 decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ZFP367 mRNA CTD PMID:19191707 NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ZMAT3 mRNA CTD PMID:19191707 NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863
JBrowse link
G Zscan29 zinc finger and SCAN domain containing 29 increases expression ISO 4-hydroxy-2-nonenal results in increased expression of ZSCAN29 mRNA CTD PMID:19191707 Ensembl chr 3:108,131,018...108,140,486 JBrowse link
G Zwilch zwilch kinetochore protein decreases expression ISO 4-hydroxy-2-nonenal results in decreased expression of ZWILCH mRNA CTD PMID:19191707 NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
JBrowse link
glycolaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases degradation
ISO glycolaldehyde inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]
glycolaldehyde results in increased degradation of ABCA1 protein
glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein]
CTD PMID:15983222 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions EXP [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde CTD PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO glycolaldehyde inhibits the reaction [ABCA1 protein binds to APOA1 protein] CTD PMID:15983222 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Cat catalase decreases response to substance
decreases activity
EXP CAT protein results in decreased susceptibility to glycolaldehyde
glycolaldehyde results in decreased activity of CAT protein
CTD PMID:21376711 PMID:21378371 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ctss cathepsin S decreases activity ISO glycolaldehyde results in decreased activity of CTSS protein CTD PMID:16671891 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Glo1 glyoxalase 1 decreases activity EXP glycolaldehyde results in decreased activity of GLO1 protein CTD PMID:21378371 NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        solvent 17050
          formic acid 9050
            formyl group 9012
              aldehyde 9012
                hydroxyaldehyde 805
                  (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal 0
                  (R)-3-hydroxy-4-oxobutanoic acid 0
                  2,3,4,5-tetrahydroxypentanal 0
                  2-deoxypentose 0
                  2-hydroxy-2-methylpropanal 0
                  20-oxoleukotriene B4 0
                  3,4-dihydroxymandelaldehyde + 0
                  4-hydroxynon-2-enal + 803
                  4-hydroxynonenal + 803
                  Melanoxazal 0
                  S-(4-hydroxy-1-oxononan-3-yl)cysteinylglycine 0
                  glycolaldehydes + 6
                  hydroxy fatty aldehyde + 0
                  lactaldehyde + 0
                  oleanolic aldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            formyl group 9012
                                              aldehyde 9012
                                                hydroxyaldehyde 805
                                                  (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal 0
                                                  (R)-3-hydroxy-4-oxobutanoic acid 0
                                                  2,3,4,5-tetrahydroxypentanal 0
                                                  2-deoxypentose 0
                                                  2-hydroxy-2-methylpropanal 0
                                                  20-oxoleukotriene B4 0
                                                  3,4-dihydroxymandelaldehyde + 0
                                                  4-hydroxynon-2-enal + 803
                                                  4-hydroxynonenal + 803
                                                  Melanoxazal 0
                                                  S-(4-hydroxy-1-oxononan-3-yl)cysteinylglycine 0
                                                  glycolaldehydes + 6
                                                  hydroxy fatty aldehyde + 0
                                                  lactaldehyde + 0
                                                  oleanolic aldehyde 0
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