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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	probe	go back to main search page
Accession:	CHEBI:50406	browse the term
Definition:	A role played by a molecular entity used to study the microscopic environment.

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Rat (515) Mouse (514) Human (535) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (12) Green Monkey (0) Naked Mole-rat (0) All
Genes (515)

1-nitropyrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily E member 1

increases expression

1-nitropyrene results in increased expression of ABCE1 mRNA

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

ATP binding cassette subfamily F member 1

increases expression

1-nitropyrene results in increased expression of ABCF1 mRNA

NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

increases expression

1-nitropyrene results in increased expression of ADAMTS1 mRNA

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

adhesion G protein-coupled receptor G6

increases expression

1-nitropyrene results in increased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adrenoceptor beta 2

multiple interactions

ADRB2 protein promotes the reaction [1-nitropyrene results in increased secretion of CXCL8 protein]

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

ALF transcription elongation factor 4

increases expression

1-nitropyrene results in increased expression of AFF4 mRNA

NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751

G

aftiphilin

increases expression

1-nitropyrene results in increased expression of AFTPH mRNA

NCBI chr14:94,871,429...94,925,625
Ensembl chr14:94,871,429...94,925,376

G

aryl hydrocarbon receptor

multiple interactions
affects response to substance

1-nitropyrene binds to and results in increased activity of AHR protein; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]
AHR affects the susceptibility to 1-nitropyrene

PMID:12117779 PMID:22044530 PMID:28186253

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldo-keto reductase family 1, member C1

multiple interactions

[AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C3

multiple interactions

[AKR1C3 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

multiple interactions

1-nitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activated leukocyte cell adhesion molecule

increases expression

1-nitropyrene results in increased expression of ALCAM mRNA

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

angiogenin

decreases expression

1-nitropyrene results in decreased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

ANTXR cell adhesion molecule 2

increases expression

1-nitropyrene results in increased expression of ANTXR2 mRNA

NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094

G

APC down-regulated 1

decreases expression

1-nitropyrene results in decreased expression of APCDD1 mRNA

NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070

G

androgen receptor

multiple interactions

1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

ARF interacting protein 1

increases expression

1-nitropyrene results in increased expression of ARFIP1 mRNA

NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

1-nitropyrene results in increased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

autophagy related 7

multiple interactions
affects response to substance
increases expression

3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
ATG7 protein affects the susceptibility to 1-nitropyrene
1-nitropyrene results in increased expression of ATG7 mRNA; 1-nitropyrene results in increased expression of ATG7 protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

G

ATP synthase peripheral stalk subunit d

multiple interactions
decreases expression

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5PD mRNA]

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATPase phospholipid transporting 8B1

increases expression

1-nitropyrene results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

BCL2-associated agonist of cell death

increases phosphorylation

1-nitropyrene results in increased phosphorylation of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

1-nitropyrene results in increased expression of BAX mRNA
TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2-related protein A1

increases expression

1-nitropyrene results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

Bcl2-like 1

decreases expression

1-nitropyrene results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

BH3 interacting domain death agonist

increases expression

1-nitropyrene results in increased expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

baculoviral IAP repeat-containing 3

increases expression

1-nitropyrene results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

bone morphogenetic protein 2

increases expression

1-nitropyrene results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

BMP-binding endothelial regulator

increases expression

1-nitropyrene results in increased expression of BMPER mRNA

NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256

G

BRCA1, DNA repair associated

decreases expression

1-nitropyrene results in decreased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

C1q and TNF related 2

decreases expression

1-nitropyrene results in decreased expression of C1QTNF2 mRNA

NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185

G

complement C1r subcomponent like

decreases expression

1-nitropyrene results in decreased expression of C1RL mRNA

NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134

G

similar to human chromosome 5 open reading frame 34

increases expression

1-nitropyrene results in increased expression of C5ORF34 mRNA

NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085

G

carbonic anhydrase 6

decreases expression

1-nitropyrene results in decreased expression of CA6 mRNA

NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644

G

caspase 2

increases activity

1-nitropyrene results in increased activity of CASP2 protein

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

multiple interactions
increases activity

1-nitropyrene results in increased cleavage of and results in increased activity of CASP3 protein; methyl-beta-cyclodextrin inhibits the reaction [1-nitropyrene results in increased activity of CASP3 protein]

PMID:17240030 PMID:21872649

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

cystathionine beta synthase

increases expression

1-nitropyrene results in increased expression of CBS mRNA

NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764

G

coiled-coil domain containing 18

increases expression

1-nitropyrene results in increased expression of CCDC18 mRNA

NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711

G

C-C motif chemokine ligand 17

decreases expression

1-nitropyrene results in decreased expression of CCL17 mRNA

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

decreases expression

1-nitropyrene results in decreased expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 20

increases expression

1-nitropyrene results in increased expression of CCL20 mRNA

PMID:19428942 PMID:19879285 PMID:21540303

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 21

decreases expression

1-nitropyrene results in decreased expression of CCL21 mRNA

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

G

C-C motif chemokine ligand 24

decreases expression

1-nitropyrene results in decreased expression of CCL24 mRNA

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 26

decreases expression

1-nitropyrene results in decreased expression of CCL26 mRNA

NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335

G

C-C motif chemokine ligand 5

increases expression

1-nitropyrene results in increased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 9

decreases expression

1-nitropyrene results in decreased expression of CCL15 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 2

increases expression

1-nitropyrene results in increased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

increases expression

1-nitropyrene results in increased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

C-C motif chemokine receptor 4

increases expression

1-nitropyrene results in increased expression of CCR4 mRNA

NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056

G

C-C motif chemokine receptor 6

decreases expression

1-nitropyrene results in decreased expression of CCR6 mRNA

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

G

C-C motif chemokine receptor 7

decreases expression

1-nitropyrene results in decreased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor 8

decreases expression

1-nitropyrene results in decreased expression of CCR8 mRNA

NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629

G

CD14 molecule

decreases expression

1-nitropyrene results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD8 subunit beta

decreases expression

1-nitropyrene results in decreased expression of CD8B1 mRNA

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

G

cadherin 1

decreases expression

1-nitropyrene results in decreased expression of CDH1 mRNA

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 13

increases expression

1-nitropyrene results in increased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cadherin 3

decreases expression

1-nitropyrene results in decreased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cyclin-dependent kinase 17

increases expression

1-nitropyrene results in increased expression of CDK17 mRNA

NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
1-nitropyrene results in increased expression of CDKN1A mRNA; 1-nitropyrene results in increased expression of CDKN1A protein

PMID:21540303 PMID:22044530

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein alpha

multiple interactions
decreases expression

[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

increases expression

1-nitropyrene results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CCAAT/enhancer binding protein delta

decreases expression

1-nitropyrene results in decreased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

CCAAT/enhancer binding protein gamma

increases expression

1-nitropyrene results in increased expression of CEBPG mRNA

NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569

G

centromere protein B

decreases expression

1-nitropyrene results in decreased expression of CENPB mRNA

NCBI chr 3:118,396,987...118,399,780
Ensembl chr 3:118,388,546...118,400,470

G

clusterin

decreases expression

1-nitropyrene results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

COMM domain containing 3

increases expression

1-nitropyrene results in increased expression of COMMD3 mRNA

NCBI chr17:81,327,444...81,331,191
Ensembl chr17:81,327,405...81,331,177

G

coronin 1C

increases expression

1-nitropyrene results in increased expression of CORO1C mRNA

NCBI chr12:42,713,024...42,785,179
Ensembl chr12:42,712,991...42,785,179

G

colony stimulating factor 2

increases expression

1-nitropyrene results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cystathionine gamma-lyase

increases expression

1-nitropyrene results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

C-X-C motif chemokine ligand 1

increases expression

1-nitropyrene results in increased expression of CXCL1 mRNA

PMID:19041380 PMID:19428942 PMID:19879285

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

increases expression

1-nitropyrene results in increased expression of CXCL10 mRNA

PMID:19428942 PMID:19879285

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

increases expression

1-nitropyrene results in increased expression of CXCL11 mRNA

PMID:19428942 PMID:19879285

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 13

decreases expression

1-nitropyrene results in decreased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 2

increases expression

1-nitropyrene results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

1-nitropyrene results in increased expression of CXCL1 mRNA

PMID:19041380 PMID:19428942 PMID:19879285

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine ligand 6

decreases expression

1-nitropyrene results in decreased expression of CXCL6 mRNA

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine receptor 2

decreases expression

1-nitropyrene results in decreased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases degradation
multiple interactions
increases stability
increases expression

1-nitropyrene results in increased degradation of CYP1A1 protein
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]
1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 protein
1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]

PMID:12117779 PMID:16280210 PMID:17240030 PMID:18493746 PMID:19961161 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects response to substance
multiple interactions

CYP1A2 affects the susceptibility to 1-nitropyrene
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene]

PMID:10727902 PMID:18493746

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression
multiple interactions
increases metabolic processing

1-nitropyrene results in increased expression of CYP1B1 mRNA; 1-nitropyrene results in increased expression of CYP1B1 protein
CYP1B1 protein promotes the reaction [1-nitropyrene results in decreased expression of GPX4 protein]; CYP1B1 protein promotes the reaction [1-nitropyrene results in decreased expression of SLC7A11 protein]; CYP1B1 protein promotes the reaction [1-nitropyrene results in increased phosphorylation of MAPK1 protein]; CYP1B1 protein promotes the reaction [1-nitropyrene results in increased phosphorylation of MAPK3 protein]
CYP1B1 protein results in increased metabolism of 1-nitropyrene

PMID:11525925 PMID:12117779 PMID:21887816 PMID:37993079

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

DNA-damage inducible transcript 3

increases expression

1-nitropyrene results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dickkopf WNT signaling pathway inhibitor 1

increases expression

1-nitropyrene results in increased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

DLC1 Rho GTPase activating protein

increases expression

1-nitropyrene results in increased expression of DLC1 mRNA

NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439

G

cyclin D binding myb-like transcription factor 1

increases expression

1-nitropyrene results in increased expression of DMTF1 mRNA

NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967

G

delta/notch-like EGF repeat containing

increases expression

1-nitropyrene results in increased expression of DNER mRNA

NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637

G

dual specificity phosphatase 10

increases expression

1-nitropyrene results in increased expression of DUSP10 mRNA

NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716

G

dual specificity phosphatase 6

increases expression

1-nitropyrene results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

early growth response 1

increases expression

1-nitropyrene results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

increases expression

1-nitropyrene results in increased expression of EHHADH mRNA

NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188

G

eukaryotic translation initiation factor 4E binding protein 1

increases expression

1-nitropyrene results in increased expression of EIF4EBP1 mRNA

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

epiregulin

increases expression

1-nitropyrene results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

endothelial cell-specific molecule 1

increases expression

1-nitropyrene results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

G

ETS variant transcription factor 5

increases expression

1-nitropyrene results in increased expression of ETV5 mRNA

NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215

G

ecotropic viral integration site 2A

increases expression

1-nitropyrene results in increased expression of EVI2A mRNA

NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843

G

exocyst complex component 5

increases expression

1-nitropyrene results in increased expression of EXOC5 mRNA

NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335

G

coagulation factor III, tissue factor

increases expression

1-nitropyrene results in increased expression of F3 mRNA

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fibroblast growth factor 5

increases expression

1-nitropyrene results in increased expression of FGF5 mRNA

NCBI chr14:11,323,827...11,346,164
Ensembl chr14:11,325,334...11,345,997

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

1-nitropyrene results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

G0/G1switch 2

increases expression

1-nitropyrene results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glycyl-tRNA synthetase 1

increases expression

1-nitropyrene results in increased expression of GARS1 mRNA

NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609

G

growth arrest-specific 1

decreases expression

1-nitropyrene results in decreased expression of GAS1 mRNA

NCBI chr17:4,482,168...4,485,153

G

guanylate binding protein 2

decreases expression

1-nitropyrene results in decreased expression of GBP2 mRNA

NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571

G

ganglioside-induced differentiation-associated-protein 1

increases expression

1-nitropyrene results in increased expression of GDAP1 mRNA

NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061

G

GLI pathogenesis-related 1

increases expression

1-nitropyrene results in increased expression of GLIPR1 mRNA

NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429

G

golgin A4

increases expression

1-nitropyrene results in increased expression of GOLGA4 mRNA

NCBI chr 8:118,208,200...118,285,003

G

glutamic--pyruvic transaminase 2

increases expression

1-nitropyrene results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 4

decreases expression
multiple interactions

1-nitropyrene results in decreased expression of GPX4 protein
CYP1B1 protein promotes the reaction [1-nitropyrene results in decreased expression of GPX4 protein]; ferrostatin-1 inhibits the reaction [1-nitropyrene results in decreased expression of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

gremlin 1, DAN family BMP antagonist

increases expression

1-nitropyrene results in increased expression of GREM1 mRNA

NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082

G

gasdermin C

decreases expression

1-nitropyrene results in decreased expression of GSDMC mRNA

NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344

G

hyaluronan binding protein 2

decreases expression

1-nitropyrene results in decreased expression of HABP2 mRNA

NCBI chr 1:255,315,870...255,350,161
Ensembl chr 1:255,315,915...255,350,160

G

heparin-binding EGF-like growth factor

increases expression

1-nitropyrene results in increased expression of HBEGF mRNA

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

hypoxia inducible factor 1 subunit alpha

increases expression

1-nitropyrene results in increased expression of HIF1A mRNA

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

high mobility group AT-hook 2

increases expression

1-nitropyrene results in increased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

heme oxygenase 1

increases expression

1-nitropyrene results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hypoxanthine phosphoribosyltransferase 1

multiple interactions

CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene]

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

affects expression
increases expression

1-nitropyrene affects the expression of HRAS mRNA
1-nitropyrene results in increased expression of HRAS mRNA

PMID:9891514 PMID:11201684 PMID:11911274

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

1-nitropyrene results in increased expression of HSPA5 protein
Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

isoleucyl-tRNA synthetase 1

increases expression

1-nitropyrene results in increased expression of IARS1 mRNA

NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237

G

intercellular adhesion molecule 1

increases expression

1-nitropyrene results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon induced transmembrane protein 1

decreases expression

1-nitropyrene results in decreased expression of IFITM1 mRNA

NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169

G

interferon-related developmental regulator 1

increases expression

1-nitropyrene results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

interleukin 10 receptor subunit beta

decreases expression

1-nitropyrene results in decreased expression of IL10RB mRNA

NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074

G

interleukin 1 alpha

increases expression

1-nitropyrene results in increased expression of IL1A mRNA

PMID:19428942 PMID:21540303

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases secretion

1-nitropyrene results in increased secretion of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 36 receptor antagonist

decreases expression

1-nitropyrene results in decreased expression of IL36RN mRNA

NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016

G

interleukin 6

increases expression
increases secretion
multiple interactions

1-nitropyrene results in increased expression of IL6 mRNA
1-nitropyrene results in increased secretion of IL6 protein
3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]

PMID:19041380 PMID:19879285 PMID:29078374

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

internexin neuronal intermediate filament protein, alpha

increases expression

1-nitropyrene results in increased expression of INA mRNA

NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330

G

inhibin subunit beta B

increases expression

1-nitropyrene results in increased expression of INHBB mRNA

NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832

G

inositol polyphosphate-4-phosphatase type II B

increases expression

1-nitropyrene results in increased expression of INPP4B mRNA

NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634

G

importin 7

increases expression

1-nitropyrene results in increased expression of IPO7 mRNA

NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938

G

interferon regulatory factor 1

increases expression

1-nitropyrene results in increased expression of IRF1 mRNA

NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166

G

integrin subunit beta 4

decreases expression

1-nitropyrene results in decreased expression of ITGB4 mRNA

NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

1-nitropyrene results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

potassium channel tetramerization domain containing 15

increases expression

1-nitropyrene results in increased expression of KCTD15 mRNA

NCBI chr 1:87,258,658...87,271,979
Ensembl chr 1:87,258,658...87,273,497

G

KRAS proto-oncogene, GTPase

multiple interactions
increases mutagenesis

[1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene; [1-nitropyrene co-treated with Polychlorinated Biphenyls] results in increased mutagenesis of KRAS gene; [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene
1-nitropyrene results in increased mutagenesis of KRAS gene

PMID:9726818 PMID:10396879 PMID:11746253 PMID:12616606

NCBI chr 4:178,185,418...178,218,484

G

keratin 34

increases expression

1-nitropyrene results in increased expression of KRT34 mRNA

NCBI chr10:84,969,988...84,974,098
Ensembl chr10:84,970,017...84,974,040

G

ligand dependent nuclear receptor corepressor

increases expression

1-nitropyrene results in increased expression of LCOR mRNA

NCBI chr 1:240,298,565...240,405,627
Ensembl chr 1:240,298,563...240,402,448

G

DNA ligase 4

increases expression

1-nitropyrene results in increased expression of LIG4 mRNA

NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040

G

lectin, mannose-binding, 1

increases expression

1-nitropyrene results in increased expression of LMAN1 mRNA

NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851

G

leucine rich repeat containing 17

decreases expression

1-nitropyrene results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845

G

lymphotoxin alpha

decreases expression

1-nitropyrene results in decreased expression of LTA mRNA

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

lymphotoxin beta

increases expression

1-nitropyrene results in increased expression of LTB mRNA

PMID:19428942 PMID:19879285

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

leucine rich adaptor protein 1-like

increases expression

1-nitropyrene results in increased expression of LURAP1L mRNA

NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438

G

MAK16 homolog

increases expression

1-nitropyrene results in increased expression of MAK16 mRNA

NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243

G

microtubule-associated protein 1 light chain 3 beta

increases expression
multiple interactions

1-nitropyrene results in increased expression of MAP1LC3B mRNA; 1-nitropyrene results in increased expression of MAP1LC3B protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

1-nitropyrene results in increased phosphorylation of MAPK1 protein
CYP1B1 protein promotes the reaction [1-nitropyrene results in increased phosphorylation of MAPK1 protein]

PMID:17240030 PMID:37993079

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases phosphorylation

1-nitropyrene results in increased phosphorylation of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

1-nitropyrene results in increased phosphorylation of MAPK3 protein
CYP1B1 protein promotes the reaction [1-nitropyrene results in increased phosphorylation of MAPK3 protein]

PMID:17240030 PMID:37993079

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 6

increases expression

1-nitropyrene results in increased expression of MAPK6 mRNA

NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720

G

mitogen-activated protein kinase 8

increases phosphorylation

1-nitropyrene results in increased phosphorylation of MAPK8 protein

PMID:17240030 PMID:37993079

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

methionyl-tRNA synthetase 1

increases expression

1-nitropyrene results in increased expression of MARS1 mRNA

NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495

G

MDM2 proto-oncogene

increases expression
multiple interactions

1-nitropyrene results in increased expression of MDM2 mRNA; 1-nitropyrene results in increased expression of MDM2 protein; 1-nitropyrene results in increased expression of MDM2 protein modified form
nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]

PMID:10837373 PMID:22044530

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

melanophilin

increases expression

1-nitropyrene results in increased expression of MLPH mRNA

NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983

G

MOB family member 4, phocein

increases expression

1-nitropyrene results in increased expression of MOB4 mRNA

NCBI chr 9:56,617,374...56,641,336
Ensembl chr 9:56,617,368...56,641,329

G

molybdenum cofactor sulfurase

increases expression

1-nitropyrene results in increased expression of MOCOS mRNA

NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187

G

motile sperm domain containing 1

increases expression

1-nitropyrene results in increased expression of MOSPD1 mRNA

NCBI chr X:133,100,200...133,127,960
Ensembl chr X:133,100,422...133,127,908
Ensembl chr 1:133,100,422...133,127,908
Ensembl chr14:133,100,422...133,127,908

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

increases expression

1-nitropyrene results in increased expression of MTHFD1L mRNA

NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905

G

myotubularin related protein 2

increases expression

1-nitropyrene results in increased expression of MTMR2 mRNA

NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172

G

MYC proto-oncogene, bHLH transcription factor

increases expression

1-nitropyrene results in increased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NADH:ubiquinone oxidoreductase subunit A1

decreases expression
multiple interactions

1-nitropyrene results in decreased expression of NDUFA1 mRNA
1-nitropyrene results in decreased expression of NDUFA1 mRNA; 1-nitropyrene results in decreased expression of NDUFA1 protein
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]

NCBI chr X:116,424,223...116,427,875
Ensembl chr X:116,424,223...116,428,633

G

NADH:ubiquinone oxidoreductase subunit A2

multiple interactions
decreases expression

3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
1-nitropyrene results in decreased expression of NDUFA2 mRNA; 1-nitropyrene results in decreased expression of NDUFA2 protein

NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076

G

NADH:ubiquinone oxidoreductase subunit C2

multiple interactions
decreases expression

[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA]

NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189

G

NADH:ubiquinone oxidoreductase subunit S4

decreases expression
multiple interactions

1-nitropyrene results in decreased expression of NDUFS4 mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]

NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846

G

NFE2 like bZIP transcription factor 2

multiple interactions

1-nitropyrene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions
increases activity

1-nitropyrene results in increased expression of NFKB1 mRNA
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]

PMID:12393170 PMID:21540303

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased expression of CXCL8 mRNA]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NOC3-like DNA replication regulator

increases expression

1-nitropyrene results in increased expression of NOC3L mRNA

NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318

G

neuregulin 1

increases expression

1-nitropyrene results in increased expression of NRG1 mRNA

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

5' nucleotidase, ecto

increases expression

1-nitropyrene results in increased expression of NT5E mRNA

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

netrin 3

decreases expression

1-nitropyrene results in decreased expression of NTN3 mRNA

NCBI chr10:13,236,905...13,240,001
Ensembl chr10:13,236,905...13,240,001

G

2'-5' oligoadenylate synthetase 1A

decreases expression

1-nitropyrene results in decreased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

2'-5'-oligoadenylate synthetase-like

increases expression

1-nitropyrene results in increased expression of OASL mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

oxysterol binding protein-like 6

increases expression

1-nitropyrene results in increased expression of OSBPL6 mRNA

NCBI chr 3:61,343,776...61,541,170
Ensembl chr 3:61,343,809...61,537,102

G

oxidation resistance 1

increases expression

1-nitropyrene results in increased expression of OXR1 mRNA

NCBI chr 7:72,528,750...72,965,666
Ensembl chr 7:72,528,786...72,965,666

G

protocadherin beta 8

decreases expression

1-nitropyrene results in decreased expression of PCDHB5 mRNA

NCBI chr18:29,065,466...29,067,805
Ensembl chr18:29,065,466...29,067,805

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

1-nitropyrene results in increased expression of PCK2 mRNA

NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283

G

platelet derived growth factor receptor beta

decreases expression

1-nitropyrene results in decreased expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

platelet-derived growth factor receptor-like

decreases expression

1-nitropyrene results in decreased expression of PDGFRL mRNA

NCBI chr16:51,347,929...51,407,850
Ensembl chr16:51,347,948...51,407,850

G

podoplanin

decreases expression

1-nitropyrene results in decreased expression of PDPN mRNA

NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656

G

phosphatidylinositol binding clathrin assembly protein

increases expression

1-nitropyrene results in increased expression of PICALM mRNA

NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

increases expression

1-nitropyrene results in increased expression of PIK3C2A mRNA

NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472

G

pirin

decreases expression

1-nitropyrene results in decreased expression of PIR mRNA

NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218

G

pleckstrin homology domain containing B1

decreases expression

1-nitropyrene results in decreased expression of PLEKHB1 mRNA

NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142

G

DNA polymerase alpha 1, catalytic subunit

increases expression

1-nitropyrene results in increased expression of POLA1 mRNA

NCBI chr X:58,034,617...58,348,612
Ensembl chr X:58,034,619...58,348,536

G

RNA polymerase II, I and III subunit E

decreases expression

1-nitropyrene results in decreased expression of POLR2E mRNA

NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643

G

protein kinase AMP-activated catalytic subunit alpha 1

increases expression

1-nitropyrene results in increased expression of PRKAA1 mRNA

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase cAMP-dependent type I regulatory subunit alpha

increases expression

1-nitropyrene results in increased expression of PRKAR1A mRNA

NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041

G

protein kinase C, eta

increases expression

1-nitropyrene results in increased expression of PRKCH mRNA

NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654

G

protein kinase, DNA-activated, catalytic subunit

increases expression

1-nitropyrene results in increased expression of PRKDC protein

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

protein arginine methyltransferase 3

increases expression

1-nitropyrene results in increased expression of PRMT3 mRNA

NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435

G

phosphoserine aminotransferase 1

increases expression

1-nitropyrene results in increased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 20S subunit beta 9

decreases expression

1-nitropyrene results in decreased expression of PSMB9 mRNA

NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512

G

proteasome 26S subunit, non-ATPase 5

increases expression

1-nitropyrene results in increased expression of PSMD5 mRNA

NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029

G

proteasome activator subunit 4

increases expression

1-nitropyrene results in increased expression of PSME4 mRNA

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

pentatricopeptide repeat domain 2

increases expression

1-nitropyrene results in increased expression of PTCD2 mRNA

NCBI chr 2:30,712,276...30,739,968
Ensembl chr 2:30,712,280...30,739,942

G

parathyroid hormone-like hormone

increases expression

1-nitropyrene results in increased expression of PTHLH mRNA

NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847

G

pleiotrophin

decreases expression

1-nitropyrene results in decreased expression of PTN mRNA

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

protein tyrosine phosphatase, receptor type, B

increases expression

1-nitropyrene results in increased expression of PTPRB mRNA

NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748

G

RAB20, member RAS oncogene family

decreases expression

1-nitropyrene results in decreased expression of RAB20 mRNA

NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529

G

RAB26, member RAS oncogene family

decreases expression

1-nitropyrene results in decreased expression of RAB26 mRNA

NCBI chr10:13,553,395...13,558,063
Ensembl chr10:13,553,395...13,558,030

G

RAB34, member RAS oncogene family

decreases expression

1-nitropyrene results in decreased expression of RAB34 mRNA

NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538

G

receptor activity modifying protein 1

decreases expression

1-nitropyrene results in decreased expression of RAMP1 mRNA

NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151

G

RAN binding protein 6

increases expression

1-nitropyrene results in increased expression of RANBP6 mRNA

NCBI chr 1:227,572,394...227,576,915
Ensembl chr 1:227,572,105...227,576,942

G

RAS p21 protein activator 2

increases expression

1-nitropyrene results in increased expression of RASA2 mRNA

NCBI chr 8:97,119,983...97,236,687
Ensembl chr 8:97,118,802...97,236,671

G

RELA proto-oncogene, NF-kB subunit

increases activity
multiple interactions

1-nitropyrene results in increased activity of RELA protein
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal oxygenase 2

increases expression

1-nitropyrene results in increased expression of RIOX2 mRNA

NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574

G

Rho family GTPase 3

increases expression

1-nitropyrene results in increased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

sacsin molecular chaperone

increases expression

1-nitropyrene results in increased expression of SACS mRNA

NCBI chr15:35,285,783...35,370,335
Ensembl chr15:35,285,782...35,370,335

G

stearoyl-CoA desaturase

decreases expression
decreases response to substance

1-nitropyrene results in decreased expression of SCD1 mRNA; 1-nitropyrene results in decreased expression of SCD1 protein
SCD1 protein results in decreased susceptibility to 1-nitropyrene

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

sodium channel epithelial 1 subunit alpha

decreases expression

1-nitropyrene results in decreased expression of SCNN1A mRNA

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

secreted and transmembrane 1B

decreases expression

1-nitropyrene results in decreased expression of SECTM1 mRNA

NCBI chr10:106,324,070...106,333,779
Ensembl chr10:106,325,203...106,333,769

G

selectin E

increases expression

1-nitropyrene results in increased expression of SELE mRNA

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

serpin family B member 8

increases expression

1-nitropyrene results in increased expression of SERPINB8 mRNA

NCBI chr13:23,626,936...23,650,277
Ensembl chr13:23,626,945...23,650,835

G

serpin family E member 1

increases expression

1-nitropyrene results in increased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

SH3 domain-containing kinase-binding protein 1

increases expression

1-nitropyrene results in increased expression of SH3KBP1 mRNA

NCBI chr X:34,877,862...35,223,013
Ensembl chr X:34,877,866...35,222,747

G

SH3 domain containing ring finger 1

increases expression

1-nitropyrene results in increased expression of SH3RF1 mRNA

NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644

G

solute carrier family 7 member 11

multiple interactions
decreases expression

CYP1B1 protein promotes the reaction [1-nitropyrene results in decreased expression of SLC7A11 protein]; ferrostatin-1 inhibits the reaction [1-nitropyrene results in decreased expression of SLC7A11 protein]

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

sarcolemma associated protein

increases expression

1-nitropyrene results in increased expression of SLMAP mRNA

NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149

G

SMAD specific E3 ubiquitin protein ligase 2

increases expression

1-nitropyrene results in increased expression of SMURF2 mRNA

NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488

G

synuclein alpha

decreases expression

1-nitropyrene results in decreased expression of SNCA mRNA

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sorting nexin 14

increases expression

1-nitropyrene results in increased expression of SNX14 mRNA

NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:89,298,114...89,390,580

G

SRY-box transcription factor 21

decreases expression

1-nitropyrene results in decreased expression of SOX21 mRNA

NCBI chr15:95,292,429...95,296,024
Ensembl chr15:95,292,265...95,296,091

G

secreted phosphoprotein 1

decreases expression

1-nitropyrene results in decreased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

stanniocalcin 2

increases expression

1-nitropyrene results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

tumor-associated calcium signal transducer 2

decreases expression

1-nitropyrene results in decreased expression of TACSTD2 mRNA

NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650

G

transgelin

increases expression

1-nitropyrene results in increased expression of TAGLN mRNA

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

threonyl-tRNA synthetase 1

increases expression

1-nitropyrene results in increased expression of TARS1 mRNA

NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717

G

Tax1 binding protein 1

increases expression

1-nitropyrene results in increased expression of TAX1BP1 mRNA

NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100

G

thrombomodulin

increases expression

1-nitropyrene results in increased expression of THBD mRNA

NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193

G

toll-like receptor 3

multiple interactions

[Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

thymopoietin

increases expression

1-nitropyrene results in increased expression of TMPO mRNA

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

thiol methyltransferase 1A

decreases expression

1-nitropyrene results in decreased expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tumor necrosis factor

increases expression
multiple interactions
increases secretion

1-nitropyrene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]
1-nitropyrene results in increased secretion of TNF protein

PMID:19041380 PMID:19428942 PMID:19879285 PMID:21540303 PMID:28633978

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

transportin 1

increases expression

1-nitropyrene results in increased expression of TNPO1 mRNA

NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375

G

DNA topoisomerase I

increases expression

1-nitropyrene results in increased expression of TOP1 mRNA

NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II beta

increases expression

1-nitropyrene results in increased expression of TOP2B mRNA

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

tumor protein p53

increases expression
increases phosphorylation
decreases expression
affects localization
affects response to substance
affects expression
multiple interactions

1-nitropyrene results in increased expression of TP53 protein; 1-nitropyrene results in increased expression of TP53 protein modified form
1-nitropyrene results in increased phosphorylation of TRP53 protein
1-nitropyrene results in decreased expression of TRP53 mRNA
1-nitropyrene results in increased expression of TRP53 mRNA
1-nitropyrene affects the localization of TRP53 protein
TP53 affects the susceptibility to 1-nitropyrene
1-nitropyrene affects the expression of TP53 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]

PMID:10837373 PMID:10928071 PMID:11201684 PMID:11911274 PMID:17240030 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tribbles pseudokinase 3

increases expression

1-nitropyrene results in increased expression of TRIB3 mRNA

NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497

G

tripartite motif-containing 23

increases expression

1-nitropyrene results in increased expression of TRIM23 mRNA

NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743

G

transient receptor potential cation channel, subfamily M, member 7

increases expression

1-nitropyrene results in increased expression of TRPM7 mRNA

NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190

G

TruB pseudouridine synthase family member 1

increases expression

1-nitropyrene results in increased expression of TRUB1 mRNA

NCBI chr 1:256,513,418...256,554,549
Ensembl chr 1:256,515,562...256,552,814

G

ubiquitin associated and SH3 domain containing, B

increases expression

1-nitropyrene results in increased expression of UBASH3B mRNA

NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201

G

ubiquitin specific peptidase 15

increases expression

1-nitropyrene results in increased expression of USP15 mRNA

NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721

G

versican

increases expression

1-nitropyrene results in increased expression of VCAN mRNA

NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637

G

vir like m6A methyltransferase associated

increases expression

1-nitropyrene results in increased expression of VIRMA mRNA

NCBI chr 5:24,961,208...25,024,660
Ensembl chr 5:24,960,778...25,023,341

G

tryptophanyl-tRNA synthetase 1

increases expression

1-nitropyrene results in increased expression of WARS1 mRNA

NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269

G

WD repeat and FYVE domain containing 3

increases expression

1-nitropyrene results in increased expression of WDFY3 mRNA

NCBI chr14:7,578,245...7,810,491
Ensembl chr14:7,606,628...7,810,482

G

Wnt family member 2

increases expression

1-nitropyrene results in increased expression of WNT2 mRNA

NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402

G

X-C motif chemokine receptor 1

decreases expression

1-nitropyrene results in decreased expression of XCR1 mRNA

NCBI chr 8:123,479,454...123,516,168
Ensembl chr 8:123,479,590...123,487,226

G

exportin for tRNA

increases expression

1-nitropyrene results in increased expression of XPOT mRNA

NCBI chr 7:57,111,536...57,152,013
Ensembl chr 7:57,111,536...57,152,099

G

zinc finger, DHHC-type containing 11

increases expression

1-nitropyrene results in increased expression of ZDHHC11 mRNA

NCBI chr 1:29,296,334...29,327,227
Ensembl chr 1:29,296,334...29,326,898

G

zinc finger E-box binding homeobox 1

increases expression

1-nitropyrene results in increased expression of ZEB1 mRNA

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

G

zinc finger protein 62

increases expression

1-nitropyrene results in increased expression of ZFP62 mRNA

NCBI chr10:33,522,618...33,539,446
Ensembl chr10:33,500,323...33,542,013

4-methylumbelliferone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects export

ABCG2 protein affects the export of Hymecromone analog

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

catalase

multiple interactions

Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

sulfotransferase family 1A member 1

increases sulfation

SULT1A1 protein results in increased sulfation of Hymecromone

NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562

G

tumor protein p53

affects activity

Hymecromone affects the activity of TP53 protein; Hymecromone metabolite affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
increases metabolic processing
increases activity
increases glucuronidation

[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; osimertinib inhibits the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:15378558 PMID:15593333 PMID:15802387 PMID:26875642 PMID:31812603 More...

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases activity
increases metabolic processing
multiple interactions
increases glucuronidation

Hymecromone results in increased activity of UGT1A3 protein
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A3 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

affects metabolic processing
increases activity
multiple interactions
increases metabolic processing
increases glucuronidation

UGT1A6 gene polymorphism affects the metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A6 protein
[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:9429234 PMID:15802387 PMID:18214896 PMID:25393417 PMID:26875642 More...

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A7C

increases glucuronidation

UGT1A7 protein results in increased glucuronidation of Hymecromone

NCBI chr 9:88,739,577...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A8

increases glucuronidation

UGT1A8 protein results in increased glucuronidation of Hymecromone

NCBI chr 9:88,727,094...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation
increases metabolic processing
increases activity
multiple interactions

UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:15378558 PMID:15802387 PMID:26875642 PMID:31812603 PMID:33290829

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A1

increases glucuronidation

UGT2A1 protein results in increased glucuronidation of Hymecromone

NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531

G

UDP glucuronosyltransferase 2 family, polypeptide B1

increases glucuronidation
increases activity
increases metabolic processing
multiple interactions

UGT2B1 protein results in increased glucuronidation of Hymecromone
UGT2B17 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
UGT2B17 protein results in increased metabolism of Hymecromone
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]

PMID:8302279 PMID:8798464 PMID:26875642 PMID:33290829

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of Hymecromone

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

G

UDP glucuronosyltransferase family 2 member B7

increases activity
increases glucuronidation
increases metabolic processing
multiple interactions

Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased glucuronidation of Hymecromone
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Androsterone inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:26875642 PMID:31812603 PMID:33290829

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

4-methylumbelliferone beta-D-glucuronide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:31812603 PMID:33290829

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

multiple interactions

[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:31812603 PMID:33290829

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

multiple interactions

[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:31812603 PMID:33290829

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

multiple interactions

[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:31812603 PMID:33290829

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 2 family, polypeptide B1

multiple interactions

[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide

NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986

G

UDP glucuronosyltransferase family 2 member B7

multiple interactions

[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]

PMID:31812603 PMID:33290829

NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604

4-methylumbelliferone sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22, member 19

multiple interactions

4-methylumbelliferyl sulfate inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]

NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538

G

solute carrier family 22, member 25

multiple interactions

4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]

NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085

4-methylumbelliferyl acetate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calreticulin

increases activity

4-methylumbelliferyl acetate results in increased activity of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

carboxylesterase 1D

multiple interactions
increases hydrolysis

Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

increases hydrolysis

CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

thioredoxin 1

increases activity

4-methylumbelliferyl acetate results in increased activity of TXN protein

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

vascular endothelial growth factor A

increases expression

4-methylumbelliferyl acetate results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

4-methylumbelliferyl beta-D-galactoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 12

decreases activity

4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 9

decreases activity

4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

4-methylumbelliferyl beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha glucosidase

multiple interactions
increases metabolic processing

GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside]

NCBI chr10:104,529,673...104,546,836
Ensembl chr10:104,529,747...104,546,836

6beta-hydroxycortisol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects chemical synthesis

CYP3A4 protein affects the chemical synthesis of 6 beta-hydroxycortisol

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

7-ethoxycoumarin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases metabolic processing

CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

7-hydroxycoumarin O(7)-glucosiduronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

UDP glucuronosyltransferase family 2 member B15

increases abundance

UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

8-anilinonaphthalene-1-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-microglobulin/bikunin precursor

affects binding

1-anilino-8-naphthalenesulfonate binds to AMBP protein

NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331

G

apolipoprotein D

affects binding

1-anilino-8-naphthalenesulfonate binds to APOD protein

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

complement C8 gamma chain

affects binding

1-anilino-8-naphthalenesulfonate binds to C8G protein

NCBI chr 3:8,320,503...8,322,087
Ensembl chr 3:8,305,920...8,323,495

G

glutathione S-transferase alpha 1

affects binding

1-anilino-8-naphthalenesulfonate binds to GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

lipocalin 1

affects binding

1-anilino-8-naphthalenesulfonate binds to LCN1 protein

NCBI chr 3:9,532,860...9,537,859
Ensembl chr 3:9,532,915...9,536,577

G

lipocalin 2

affects binding

1-anilino-8-naphthalenesulfonate binds to LCN2 protein

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

odorant binding protein 2A

affects binding

1-anilino-8-naphthalenesulfonate binds to OBP2A protein

NCBI chr 3:8,505,963...8,509,269
Ensembl chr 3:8,505,990...8,509,269

G

orosomucoid 1

affects binding

1-anilino-8-naphthalenesulfonate binds to ORM1 protein

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

progestagen associated endometrial protein

affects binding

1-anilino-8-naphthalenesulfonate binds to PAEP protein

NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430

G

prostaglandin D2 synthase

affects binding

1-anilino-8-naphthalenesulfonate binds to PTGDS protein

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

transthyretin

affects binding
multiple interactions

1-anilino-8-naphthalenesulfonate binds to TTR protein
3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]

NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008

auraptene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

cyclin A2

affects expression

aurapten affects the expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B2

affects expression

aurapten affects the expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cell division cycle 45

affects expression

aurapten affects the expression of CDC45 mRNA

NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619

G

cyclin-dependent kinase 1

affects expression

aurapten affects the expression of CDK1 mRNA

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase inhibitor 2B

affects expression

aurapten affects the expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cyclin-dependent kinase inhibitor 2C

affects expression

aurapten affects the expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

G

checkpoint kinase 1

affects expression

aurapten affects the expression of CHEK1 mRNA

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

affects expression

aurapten affects the expression of CHEK2 mRNA

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

catenin beta 1

decreases expression

aurapten results in decreased expression of CTNNB1 protein mutant form

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DNA-damage inducible transcript 3

affects expression

aurapten affects the expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dual specificity phosphatase 1

affects expression

aurapten affects the expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

E2F transcription factor 1

affects expression

aurapten affects the expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

affects expression

aurapten affects the expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

growth arrest and DNA-damage-inducible, alpha

affects expression

aurapten affects the expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

aurapten affects the expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 20B

affects expression

aurapten affects the expression of KIF20B mRNA

NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787

G

minichromosome maintenance complex component 3

affects expression

aurapten affects the expression of MCM3 mRNA

NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314

G

minichromosome maintenance complex component 6

affects expression

aurapten affects the expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

NFE2 like bZIP transcription factor 2

affects response to substance

NFE2L2 protein affects the susceptibility to aurapten

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

prostaglandin-endoperoxide synthase 2

multiple interactions

aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

ubiquitin-like with PHD and ring finger domains 1

affects expression

aurapten affects the expression of UHRF1 mRNA

NCBI chr 9:1,133,117...1,154,639
Ensembl chr 9:1,134,909...1,154,631

G

vascular endothelial growth factor A

multiple interactions

aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

carbon monoxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases activity

Carbon Monoxide results in increased activity of ABCC2 protein

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

adiponectin, C1Q and collagen domain containing

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adrenomedullin

increases expression

Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

anterior gradient 2, protein disulphide isomerase family member

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA

NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371

G

angiotensinogen

decreases response to substance

AGT protein results in decreased susceptibility to Carbon Monoxide

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]

PMID:17179207 PMID:18037988 PMID:18215737 PMID:18845810 PMID:19356108

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

increases activity
multiple interactions

Carbon Monoxide results in increased activity of ALAD protein
Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]

PMID:1032310 PMID:6740708

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

amphiregulin

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

BTB domain and CNC homolog 1

decreases phosphorylation

Carbon Monoxide results in decreased phosphorylation of BACH1 protein

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BCL2-associated agonist of cell death

multiple interactions

Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-related protein A1

multiple interactions

BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

brain-derived neurotrophic factor

multiple interactions
decreases expression

Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein
Carbon Monoxide results in decreased expression of BDNF mRNA

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

baculoviral IAP repeat-containing 3

multiple interactions

BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

caspase 3

multiple interactions
increases expression
increases activity

[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP3 mRNA]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
Carbon Monoxide results in increased expression of CASP3 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA
Carbon Monoxide results in increased activity of CASP3 protein

PMID:17173083 PMID:19356108 PMID:19520142 PMID:25562542 PMID:31268311 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 7

increases activity

Carbon Monoxide results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

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caspase 8

increases activity
multiple interactions

Carbon Monoxide results in increased activity of CASP8 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA

PMID:25562542 PMID:31268311

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

increases activity
multiple interactions
increases expression

Carbon Monoxide results in increased activity of CASP9 protein
sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 mRNA]; sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of CASP9 protein]
Carbon Monoxide results in increased expression of CASP9 mRNA; Carbon Monoxide results in increased expression of CASP9 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA

PMID:25562542 PMID:31268311 PMID:37860845

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

multiple interactions
decreases expression

CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide results in decreased expression of CAT protein
CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]

PMID:17179207 PMID:18845810 PMID:34032369

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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C-C motif chemokine ligand 1

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

CD86 molecule

decreases expression

Carbon Monoxide results in decreased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

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chloride channel accessory 1

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

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collagen type XI alpha 1 chain

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

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C-reactive protein

increases expression

Carbon Monoxide results in increased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

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C-X-C motif chemokine ligand 11

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

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cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

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cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA]

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

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cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

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cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
multiple interactions

Carbon Monoxide results in decreased activity of CYP2E1 protein
Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]

PMID:1903091 PMID:15036350

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

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dynamin 1-like

multiple interactions
increases expression

sulforaphane inhibits the reaction [Carbon Monoxide results in increased expression of DNM1L protein]

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

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dual oxidase 2

increases expression
decreases expression

Carbon Monoxide results in increased expression of DUOX2 mRNA
Carbon Monoxide results in decreased expression of DUOX2 protein

NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902

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endothelin 1

increases expression
multiple interactions

Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]

PMID:11781074 PMID:12969895 PMID:20197249

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

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early growth response 1

multiple interactions

Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

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enolase 2

increases secretion

Carbon Monoxide results in increased secretion of ENO2 protein

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

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erythropoietin

increases expression

Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

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endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Carbon Monoxide results in increased expression of ERO1A mRNA

NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478

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ezrin

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in decreased expression of EZR protein

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

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fibrinogen beta chain

multiple interactions

FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

forkhead box P3

multiple interactions

[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of FOXP3 gene; [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter

PMID:29317916 PMID:33603036

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

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GA binding protein transcription factor subunit alpha

increases expression
multiple interactions

Carbon Monoxide results in increased expression of GABPA mRNA
Carbon Monoxide results in increased expression of GABPA protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]

NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605

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GATA binding protein 4

multiple interactions

Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein]

NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636

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glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

Carbon Monoxide results in increased expression of GCLC mRNA
[NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

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G protein-coupled receptor 182

increases expression

Carbon Monoxide results in increased expression of GPR182 mRNA

NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210

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glutathione peroxidase 4

multiple interactions

Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

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glycogen synthase kinase 3 beta

multiple interactions
increases phosphorylation

Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]
Carbon Monoxide results in increased phosphorylation of GSK3B protein

PMID:18037988 PMID:18845810

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

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heme oxygenase 1

multiple interactions
increases chemical synthesis
increases expression
increases activity

Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased chemical synthesis of Carbon Monoxide
[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]

PMID:11880364 PMID:16365149 PMID:18037988 PMID:18845810 PMID:19520142 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

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heme oxygenase 2

multiple interactions
affects chemical synthesis
affects abundance

Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
HMOX2 protein affects the chemical synthesis of Carbon Monoxide
HMOX2 protein affects the abundance of Carbon Monoxide

PMID:11342580 PMID:12969895

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

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intercellular adhesion molecule 1

multiple interactions

[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:19356108 PMID:19608869

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

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interferon gamma

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IFNG gene

PMID:16365149 PMID:29621558 PMID:33603036

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

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interleukin 10

multiple interactions
increases expression

Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL10 gene
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL10 protein]]
Carbon Monoxide results in increased expression of IL10 mRNA

PMID:21444764 PMID:31732924 PMID:33603036

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

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interleukin 12B

multiple interactions

Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

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interleukin 13

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

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interleukin 17A

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

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interleukin 18

decreases response to substance
multiple interactions

Carbon Monoxide results in decreased susceptibility to IL18 protein
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

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interleukin 1 beta

decreases expression
multiple interactions
increases expression

Carbon Monoxide results in decreased expression of IL1B protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of IL1B protein]]

PMID:21444764 PMID:31732924

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 1 receptor-like 1

increases expression
multiple interactions

Carbon Monoxide results in increased expression of IL1RL1 protein
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL1RL1 protein]]

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

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interleukin 33

multiple interactions
increases expression

(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]]

NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373

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interleukin 4

decreases expression
multiple interactions

Carbon Monoxide results in decreased expression of IL4 protein
[Air Pollutants results in increased abundance of Carbon Monoxide] which affects the methylation of IL4 gene
[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein; iodopravadoline inhibits the reaction [[Carbon Monoxide co-treated with (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone] results in increased expression of IL4 protein]
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein

PMID:21444764 PMID:29621558 PMID:31732924 PMID:33603036

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

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interleukin 6

multiple interactions
increases expression

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]

PMID:18629312 PMID:19608869 PMID:19750100 PMID:31268311

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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interferon regulatory factor 8

decreases activity

Carbon Monoxide results in decreased activity of IRF8 protein

NCBI chr19:48,790,581...48,812,363
Ensembl chr19:48,790,588...48,811,829

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Kelch-like ECH-associated protein 1

multiple interactions

Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

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mitogen activated protein kinase 14

multiple interactions

MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

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myelin basic protein

affects response to substance

MBP polymorphism affects the susceptibility to Carbon Monoxide

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

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mitofusin 2

multiple interactions
decreases expression

sulforaphane affects the reaction [Carbon Monoxide results in decreased expression of MFN2 protein]; sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of MFN2 mRNA]
Carbon Monoxide results in decreased expression of MFN2 mRNA; Carbon Monoxide results in decreased expression of MFN2 protein

NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342

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microRNA 1224

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA

NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986

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microRNA 186

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA

NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891

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microRNA 21

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

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microRNA 342

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA

NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367

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microRNA 374b

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA

NCBI chr X:68,591,732...68,591,799
Ensembl chr X:68,591,732...68,591,799

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microRNA 615

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA

NCBI chr 7:134,151,887...134,151,978
Ensembl chr 7:134,151,887...134,151,978

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microRNA 93

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA

NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221

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microRNA let-7i

multiple interactions

[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA

NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571

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matrix metallopeptidase 9

increases expression

Carbon Monoxide results in increased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

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mannose receptor, C type 1

multiple interactions

[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein; iodopravadoline inhibits the reaction [[(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone co-treated with Carbon Monoxide] results in increased expression of MRC1 protein]

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

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N-myc downstream regulated 1

multiple interactions

Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein]

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
increases localization
decreases phosphorylation

Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of NFE2L2 mRNA; Carbon Monoxide results in increased expression of NFE2L2 protein
[NFE2L2 protein co-treated with Carbon Monoxide] results in increased expression of GCLC mRNA; Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]; NFE2L2 protein inhibits the reaction [Carbon Monoxide results in decreased expression of CAT protein]; NFE2L2 protein promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 mRNA]
Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein

PMID:18845810 PMID:25348283 PMID:34032369

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

affects expression
multiple interactions

Carbon Monoxide affects the expression of NGF mRNA
Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions
decreases expression

Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Carbon Monoxide results in decreased expression of NOS2 protein

PMID:12201358 PMID:22046279

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide A

increases expression

Carbon Monoxide results in increased expression of NPPA mRNA

NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351

G

nuclear respiratory factor 1

multiple interactions
increases expression
increases localization

AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]
Carbon Monoxide results in increased expression of NRF1 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
Carbon Monoxide results in increased expression of NRF1 mRNA

PMID:17179207 PMID:18845810

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

neurotrophin 3

decreases expression
multiple interactions

Carbon Monoxide results in decreased expression of NTF3 mRNA
Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

platelet and endothelial cell adhesion molecule 1

increases expression

[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

phospholipase A2 group VII

affects expression

Carbon Monoxide affects the expression of PLA2G7

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

G

DNA polymerase gamma, catalytic subunit

increases expression

Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

G

peroxisome proliferator-activated receptor gamma

multiple interactions

[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

increases expression
multiple interactions

Carbon Monoxide results in increased expression of PPARGC1A mRNA
Carbon Monoxide results in increased expression of PPARGC1A protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

proteoglycan 2, pro eosinophil major basic protein

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA

NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions
decreases expression

sulforaphane inhibits the reaction [Carbon Monoxide results in decreased expression of PRKAA2 mRNA]

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

phosphatase and tensin homolog

multiple interactions

Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

REL proto-oncogene, NF-kB subunit

multiple interactions

[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

selectin P

increases expression

Carbon Monoxide results in increased expression of SELP protein modified form

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

surfactant protein D

multiple interactions

[[Vehicle Emissions results in increased abundance of Air Pollutants] which results in increased abundance of Carbon Monoxide] which results in increased expression of SFTPD protein

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

superoxide dismutase 1

decreases expression

Carbon Monoxide results in decreased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
increases expression

Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of SOD2 protein

PMID:17179207 PMID:18037988 PMID:18845810

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sclerostin domain containing 1

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA

NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579

G

transcription factor A, mitochondrial

increases expression
multiple interactions

Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

tumor necrosis factor

multiple interactions
increases expression
decreases expression
decreases response to substance

(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; iodopravadoline inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [Carbon Monoxide results in increased expression of TNF protein]]
Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
Carbon Monoxide results in decreased susceptibility to TNF protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in decreased expression of TNF protein

CTD
RGD

PMID:11880364 PMID:17173083 PMID:19356108 PMID:19608869 PMID:21444764 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1B

increases expression

Carbon Monoxide results in increased expression of TNFRSF1B protein modified form

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF superfamily member 4

multiple interactions

[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA

NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788

G

uncoupling protein 2

multiple interactions

UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

vasodilator-stimulated phosphoprotein

decreases phosphorylation

Carbon Monoxide results in decreased phosphorylation of VASP protein

NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061

G

vascular cell adhesion molecule 1

multiple interactions

Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]

PMID:19356108 PMID:19608869

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

xanthine dehydrogenase

increases activity
increases metabolic processing

Carbon Monoxide results in increased activity of XDH protein
Carbon Monoxide results in increased metabolism of XDH protein

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

chlortetracycline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity

Chlortetracycline results in decreased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutathione S-transferase pi 1

multiple interactions

Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

coumaphos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein

PMID:30625376 PMID:33844597

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

androgen receptor

multiple interactions

Coumaphos inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

estrogen receptor 1

multiple interactions

Coumaphos binds to and results in increased activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

Coumaphos binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

glycerol-3-phosphate acyltransferase 3

increases expression

Coumaphos results in increased expression of GPAT3 mRNA

NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490

G

LIF, interleukin 6 family cytokine

increases expression

Coumaphos results in increased expression of LIF mRNA

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Coumaphos binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Coumaphos binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

retinoic acid receptor, alpha

increases activity

Coumaphos results in increased activity of RARA protein

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

solute carrier family 7 member 11

increases expression

Coumaphos results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

thyroid hormone receptor beta

multiple interactions

Coumaphos binds to and results in increased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

tumor protein p53

affects activity

Coumaphos metabolite affects the activity of TP53 protein

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

filipin III

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Filipin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]
Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]

PMID:12614848 PMID:17172471

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome b-245 beta chain

multiple interactions

Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

desmin

multiple interactions

Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

heat shock protein family B (small) member 1

multiple interactions

Filipin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein]

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

intercellular adhesion molecule 1

multiple interactions

Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

Janus kinase 1

multiple interactions

Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein]

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

mitogen-activated protein kinase kinase 6

multiple interactions

Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein]

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen activated protein kinase kinase kinase 7

multiple interactions

Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein]

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

multiple interactions

Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

neutrophil cytosolic factor 1

multiple interactions

Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NPHS2 stomatin family member, podocin

multiple interactions

Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]

NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313

G

prion protein

increases secretion
decreases expression
multiple interactions

Filipin results in increased secretion of PRNP protein
Filipin results in decreased expression of PRNP protein alternative form
[Copper co-treated with Filipin] results in increased cleavage of PRNP protein; Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]

PMID:11994310 PMID:19597535

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of SRC protein]

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

vascular cell adhesion molecule 1

multiple interactions

Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

fluorescein 5-isothiocyanate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 7

affects binding

Fluorescein-5-isothiocyanate binds to ABCB7 protein

NCBI chr X:69,295,598...69,436,775
Ensembl chr X:69,295,552...69,436,858

G

aldo-keto reductase family 1, member C2

increases expression

Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

annexin A4

affects binding

Fluorescein-5-isothiocyanate binds to ANXA4 protein

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

Rho GTPase activating protein 6

affects binding

Fluorescein-5-isothiocyanate binds to ARHGAP6 protein

NCBI chr X:24,953,464...25,490,003
Ensembl chr X:24,953,464...25,488,663

G

5-azacytidine induced 2

affects binding

Fluorescein-5-isothiocyanate binds to AZI2 protein

NCBI chr 8:117,773,248...117,797,844
Ensembl chr 8:117,773,279...117,797,847

G

capping actin protein of muscle Z-line subunit beta

affects binding

Fluorescein-5-isothiocyanate binds to CAPZB protein

NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409

G

CD109 molecule

affects binding

Fluorescein-5-isothiocyanate binds to CD109 protein

NCBI chr 8:79,454,480...79,569,195
Ensembl chr 8:79,454,480...79,569,194

G

CD180 molecule

affects binding

Fluorescein-5-isothiocyanate binds to CD180 protein

NCBI chr 2:33,855,940...33,870,046
Ensembl chr 2:33,855,991...33,899,936

G

CD86 molecule

increases expression

Fluorescein-5-isothiocyanate results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

CD93 molecule

affects binding

Fluorescein-5-isothiocyanate binds to CD93 protein

NCBI chr 3:135,891,859...135,898,378
Ensembl chr 3:135,891,859...135,898,378

G

cell division cycle 20

affects binding

Fluorescein-5-isothiocyanate binds to CDC20 protein

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

COPI coat complex subunit alpha

affects binding

Fluorescein-5-isothiocyanate binds to COPA protein

NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DDB1 and CUL4 associated factor 4

affects binding

Fluorescein-5-isothiocyanate binds to DCAF4 protein

NCBI chr 6:103,154,847...103,180,992
Ensembl chr 6:103,154,867...103,180,982

G

DOT1 like histone lysine methyltransferase

affects binding

Fluorescein-5-isothiocyanate binds to DOT1L protein

NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475

G

elaC ribonuclease Z 1

affects binding

Fluorescein-5-isothiocyanate binds to ELAC1 protein

NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936

G

ectonucleotide pyrophosphatase/phosphodiesterase 7

affects binding

Fluorescein-5-isothiocyanate binds to ENPP7 protein

NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589

G

fibronectin leucine rich transmembrane protein 3

affects binding

Fluorescein-5-isothiocyanate binds to FLRT3 protein

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

fibronectin 1

affects binding

Fluorescein-5-isothiocyanate binds to FN1 protein

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

heme oxygenase 1

increases expression
multiple interactions

Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 5

affects binding

Fluorescein-5-isothiocyanate binds to HSPA5 protein

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 9

affects binding

Fluorescein-5-isothiocyanate binds to HSPA9 protein

NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292

G

interferon gamma

multiple interactions

[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IFNG protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein

PMID:29198882 PMID:36870414

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects binding

Fluorescein-5-isothiocyanate binds to IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

IKAROS family zinc finger 4

affects binding

Fluorescein-5-isothiocyanate binds to IKZF4 protein

NCBI chr 7:1,063,283...1,102,940
Ensembl chr 7:1,056,890...1,084,341

G

interleukin 17A

multiple interactions

[Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17 receptor E

affects binding

Fluorescein-5-isothiocyanate binds to IL17RE protein

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 31 receptor A

affects binding

Fluorescein-5-isothiocyanate binds to IL31RA protein

NCBI chr 2:44,118,748...44,189,943
Ensembl chr 2:44,122,624...44,183,767

G

interleukin 4

multiple interactions
increases expression

[Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tributyrin] results in increased secretion of IL4 protein; [Fluorescein-5-isothiocyanate co-treated with tricaproin] results in increased secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]]

PMID:27871981 PMID:29198882 PMID:36870414

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

Ly6/Plaur domain containing 3

affects binding

Fluorescein-5-isothiocyanate binds to LYPD3 protein

NCBI chr 1:80,226,449...80,230,901
Ensembl chr 1:80,226,449...80,230,901

G

MAF bZIP transcription factor F

increases expression

Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

G

mitogen-activated protein kinase kinase kinase 20

affects binding

Fluorescein-5-isothiocyanate binds to MAP3K20 protein

NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions
increases phosphorylation

Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

metallothionein 2A

increases expression

Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

myosin binding protein C1

affects binding

Fluorescein-5-isothiocyanate binds to MYBPC1 protein

NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957

G

NFE2 like bZIP transcription factor 2

multiple interactions

[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]

PMID:20491607 PMID:27871981

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

phospholipase C, epsilon 1

affects binding

Fluorescein-5-isothiocyanate binds to PLCE1 protein

NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438

G

periostin

affects binding

Fluorescein-5-isothiocyanate binds to POSTN protein

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

PPARG related coactivator 1

affects binding

Fluorescein-5-isothiocyanate binds to PPRC1 protein

NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587

G

protein kinase C, beta

increases expression

Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

pleckstrin and Sec7 domain containing 4

affects binding

Fluorescein-5-isothiocyanate binds to PSD4 protein

NCBI chr 3:7,137,069...7,173,571
Ensembl chr 3:7,137,155...7,173,571

G

proteasome 26S subunit, non-ATPase 14

affects binding

Fluorescein-5-isothiocyanate binds to PSMD14 protein

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sodium voltage-gated channel alpha subunit 5

affects binding

Fluorescein-5-isothiocyanate binds to SCN5A protein

NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769

G

SKI family transcriptional corepressor 1

affects binding

Fluorescein-5-isothiocyanate binds to SKOR1 protein

NCBI chr 8:63,599,153...63,609,727
Ensembl chr 8:63,599,165...63,607,756

G

solute carrier family 10 member 1

multiple interactions
increases uptake

Taurocholic Acid promotes the reaction [SLC10A1 protein results in increased uptake of Fluorescein-5-isothiocyanate]

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 38, member 10

affects binding

Fluorescein-5-isothiocyanate binds to SLC38A10 protein

NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

signal transducer and activator of transcription 5A

multiple interactions
increases phosphorylation

diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]]

NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866

G

signal transducer and activator of transcription 6

increases phosphorylation
multiple interactions

Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

transient receptor potential cation channel, subfamily A, member 1

affects binding

Fluorescein-5-isothiocyanate binds to TRPA1 protein

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

thymic stromal lymphopoietin

increases expression
multiple interactions

Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

thioredoxin 1

increases expression

Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

ubiquitin specific peptidase 3

affects binding

Fluorescein-5-isothiocyanate binds to USP3 protein

NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111

N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

pyrene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 2, lysosomal

affects expression
multiple interactions

pyrene affects the expression of ACP2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein

NCBI chr 3:77,175,022...77,185,180
Ensembl chr 3:77,175,895...77,185,680

G

aryl hydrocarbon receptor

multiple interactions
affects binding
affects response to substance
increases activity

pyrene binds to and results in increased activity of AHR protein; pyrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
pyrene binds to AHR protein
[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA; [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A6A mRNA; AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]
pyrene results in increased activity of AHR protein
[benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased expression of AHR mRNA; [pyrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; fluoranthene promotes the reaction [pyrene results in increased activity of AHR protein]; pyrene promotes the reaction [fluoranthene results in increased activity of AHR protein]

PMID:3024361 PMID:12850102 PMID:17618724 PMID:17665671 PMID:28710019 More...

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions

[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]

PMID:28710019 PMID:30980910

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

aldehyde dehydrogenase 3 family, member A1

decreases expression

pyrene results in decreased expression of ALDH3A1 mRNA

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

androgen receptor

multiple interactions

[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; pyrene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; pyrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein]

PMID:18324785 PMID:26022396 PMID:30980910 PMID:33049310

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects expression

[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
pyrene affects the expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

caspase 3

increases expression
multiple interactions
increases activity

pyrene results in increased expression of CASP3 mRNA
pyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]
pyrene results in increased activity of CASP3 protein
pyrene results in increased expression of CASP3 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein

PMID:19815060 PMID:28803881 PMID:31368503 PMID:35908932

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity

pyrene results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

cyclin A2

multiple interactions
decreases expression

[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
pyrene results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

multiple interactions
increases expression

[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
pyrene results in increased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Cd63 molecule

decreases expression

pyrene results in decreased expression of CD63 protein

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

Cd81 molecule

decreases expression

pyrene results in decreased expression of CD81 protein

NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660

G

cyclin dependent kinase 2

multiple interactions
increases expression

[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
pyrene results in increased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

catechol-O-methyltransferase

multiple interactions

[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
affects expression

[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
pyrene affects the expression of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases expression
increases expression
increases activity
increases hydroxylation

[Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of CYP1A1 mRNA; [fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
pyrene results in decreased expression of CYP1A1 mRNA
pyrene results in increased expression of CYP1A1 mRNA; pyrene results in increased expression of CYP1A1 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA
pyrene results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of pyrene

PMID:7750161 PMID:15016593 PMID:15566942 PMID:16906435 PMID:25956473 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases hydroxylation
increases expression
multiple interactions

CYP1A2 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1A2 mRNA
pyrene results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of CYP1A2 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of and results in increased activity of CYP1A2 protein

PMID:7750161 PMID:15016593 PMID:17618724 PMID:26160115 PMID:30240548

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases hydroxylation
multiple interactions
decreases expression
increases expression

CYP1B1 protein results in increased hydroxylation of pyrene
pyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]
pyrene results in decreased expression of CYP1B1 mRNA
pyrene results in increased expression of CYP1B1 protein
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; pyrene binds to and results in decreased activity of CYP1B1 protein; pyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]

PMID:15016593 PMID:15566942 PMID:19365803 PMID:19563207 PMID:30248327 More...

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases expression

pyrene results in increased expression of CYP2B1 mRNA

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

pyrene results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

pyrene results in increased expression of CYP2B6 mRNA
pyrene results in increased expression of CYP2B10 mRNA
NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]
[fluoranthene co-treated with Benzo(a)pyrene] inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with Benzo(a)pyrene] inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with fluoranthene] results in increased expression of CYP2B6 mRNA; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]

PMID:17618724 PMID:26160115 PMID:33249052

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

affects expression

pyrene affects the expression of CYP2C11 mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects expression

pyrene affects the expression of CYP2C6 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

pyrene results in decreased expression of CYP2E1 mRNA

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

increases expression

pyrene results in increased expression of CYP3A23-3A1 mRNA

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

estrogen receptor 1

multiple interactions

[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; pyrene binds to and results in increased activity of ESR1 protein

PMID:30980910 PMID:33049310

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

pyrene binds to and results in increased activity of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

gap junction protein, beta 1

decreases expression

pyrene results in decreased expression of GJB1 protein

NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925

G

glutathione S-transferase alpha 1

decreases expression

pyrene results in decreased expression of GSTA1 mRNA

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase mu 1

multiple interactions
increases expression

[Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of GSTM1 protein
pyrene results in increased expression of GSTM1 mRNA

PMID:25956473 PMID:26160115

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase, mu 5

increases expression

pyrene results in increased expression of GSTM3 mRNA

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

H2A.X variant histone

multiple interactions

[pyrene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein; [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

heat shock protein family A (Hsp70) member 1A

increases expression

pyrene results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

intercellular adhesion molecule 1

increases expression

pyrene results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

affects activity

pyrene affects the activity of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 4

increases expression

pyrene results in increased expression of IL4 mRNA; pyrene results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

nuclear factor kappa B subunit 2

multiple interactions

[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NAD(P)H quinone dehydrogenase 1

increases activity

pyrene results in increased activity of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

pyrene binds to and results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
increases expression
decreases expression
increases activity
increases response to substance

AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]; NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione]; NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]; pyrene affects the localization of and results in increased activity of NR1I3 protein
pyrene results in decreased expression of NR1I3 mRNA
pyrene results in increased activity of NR1I3 protein
NR1I3 results in increased susceptibility to pyrene
[Benzo(a)pyrene co-treated with fluoranthene] inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; [Benzo(a)pyrene co-treated with pyrene] inhibits the reaction [fluoranthene results in increased expression of NR1I3 mRNA]; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; fluoranthene inhibits the reaction [pyrene results in increased expression of NR1I3 mRNA]; pyrene inhibits the reaction [fluoranthene results in increased expression of NR1I3 mRNA]

PMID:17618724 PMID:26160115 PMID:28927721 PMID:30240548 PMID:33249052

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

poly (ADP-ribose) polymerase 1

increases cleavage

pyrene results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 6 interacting protein

increases expression

pyrene results in increased expression of PDCD6IP protein

NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773

G

progesterone receptor

multiple interactions

pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

phosphatidylinositol glycan anchor biosynthesis, class A

increases mutagenesis

pyrene results in increased mutagenesis of PIGA

NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804

G

peroxisome proliferator-activated receptor gamma

multiple interactions

pyrene binds to and results in increased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Docosahexaenoic Acids co-treated with pyrene] results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

toll-like receptor 3

multiple interactions

[Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

tumor necrosis factor

multiple interactions

TNF protein promotes the reaction [pyrene results in increased expression of CXCL8 mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions
increases expression

pyrene inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein]

PMID:22120587 PMID:35908932

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor susceptibility 101

increases expression

pyrene results in increased expression of TSG101 protein

NCBI chr 1:97,412,689...97,442,589
Ensembl chr 1:97,410,848...97,442,554

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions

[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

decreases expression
multiple interactions

pyrene results in decreased expression of UGT1A6 mRNA
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA

PMID:15566942 PMID:26160115

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

scopoletin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acyltransferase 1A

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA]

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA carboxylase alpha

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein]

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA oxidase 1

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA synthetase long-chain family member 1

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA]

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adiponectin receptor 2

multiple interactions
increases expression

Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]
scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats

CTD
RGD

PMID:26115886 PMID:26115886

NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355

G

activating transcription factor 4

decreases expression

Scopoletin results in decreased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2 associated X, apoptosis regulator

multiple interactions

Scopoletin inhibits the reaction [Glucose results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Scopoletin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

Scopoletin inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]; Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
Scopoletin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]

PMID:34979142 PMID:37619648

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

Scopoletin inhibits the reaction [Glucose results in increased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cell death-inducing DFFA-like effector a

multiple interactions

Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA]

NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481

G

cytochrome c, somatic

multiple interactions

Scopoletin inhibits the reaction [Glucose results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

DNA-damage inducible transcript 3

multiple interactions

Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA]; Scopoletin inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

fatty acid synthase

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

glutamic--pyruvic transaminase

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

[Glycochenodeoxycholic Acid co-treated with Scopoletin] results in increased expression of HSPA5 mRNA; [Scopoletin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA
Scopoletin results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

interleukin 10

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 6

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lipase E, hormone sensitive type

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

mitogen activated protein kinase 1

multiple interactions

Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK3 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Scopoletin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK8 protein]; Scopoletin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein]

PMID:34979142 PMID:37619648

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MYD88, innate immune signal transduction adaptor

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

poly (ADP-ribose) polymerase 1

multiple interactions

Scopoletin inhibits the reaction [Glucose results in decreased expression of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

patatin-like phospholipase domain containing 2

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA]

NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805

G

peroxisome proliferator activated receptor alpha

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

sterol regulatory element binding transcription factor 1

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

TIR domain containing adaptor molecule 1

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA]

NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147

G

toll-like receptor 4

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Scopoletin

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of Scopoletin

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A6

increases glucuronidation

UGT1A6 protein results in increased glucuronidation of Scopoletin

NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Scopoletin

PMID:15044611 PMID:15802387

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

UGT2B15 protein results in increased metabolism of Scopoletin

NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589

G

XPC complex subunit, DNA damage recognition and repair factor

affects response to substance

XPC protein affects the susceptibility to Scopoletin

NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010

scopolin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin degrading enzyme

multiple interactions

scopolin binds to and affects the activity of IDE protein

NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440

G

uroporphyrinogen decarboxylase

multiple interactions

scopolin binds to and affects the activity of UROD protein

NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808

umbelliferone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

multiple interactions

7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

aldo-keto reductase family 1, member C3

multiple interactions
increases expression

7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]
7-hydroxycoumarin results in increased expression of AKR1C3 mRNA; 7-hydroxycoumarin results in increased expression of AKR1C3 protein

PMID:22964423 PMID:28263721

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 7, member A2

multiple interactions
increases expression

7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
7-hydroxycoumarin results in increased expression of AKR7A2 mRNA; 7-hydroxycoumarin results in increased expression of AKR7A2 protein

PMID:22964423 PMID:28263721 PMID:30849339

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

aldo-keto reductase family 7 member A3

increases expression

7-hydroxycoumarin results in increased expression of AKR7A3 mRNA

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

activating transcription factor 4

decreases expression

7-hydroxycoumarin results in decreased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

7-hydroxycoumarin results in increased expression of BAX protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]]; 7-hydroxycoumarin inhibits the reaction [Glycerol results in increased expression of BAX protein]

PMID:15964220 PMID:34409680

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

7-hydroxycoumarin results in decreased expression of BCL2 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]]; 7-hydroxycoumarin inhibits the reaction [Glycerol results in decreased expression of BCL2 protein]

PMID:15964220 PMID:34409680

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases activity

7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased activity of CASP3 protein]
7-hydroxycoumarin results in increased activity of CASP3 protein

PMID:34979142 PMID:37704181

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

7-hydroxycoumarin results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cAMP responsive element binding protein 1

increases expression
multiple interactions

7-hydroxycoumarin results in increased expression of CREB1 mRNA
7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CREB1 mRNA]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytoglobin

multiple interactions
increases expression

7-hydroxycoumarin inhibits the reaction [Cisplatin results in decreased expression of CYGB protein]
7-hydroxycoumarin results in increased expression of CYGB protein

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[CYP1A2 protein results in increased metabolism of coumarin] which results in increased abundance of 7-hydroxycoumarin

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

DNA-damage inducible transcript 3

multiple interactions

7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased expression of DDIT3 mRNA]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

forkhead box O3

multiple interactions

7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of FOXO3 mRNA]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

hepatitis A virus cellular receptor 1

multiple interactions

7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein]

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

[7-hydroxycoumarin co-treated with Palmitic Acid] results in increased expression of HSPA5 mRNA
7-hydroxycoumarin results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

multiple interactions

7-hydroxycoumarin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

7-hydroxycoumarin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Janus kinase 2

multiple interactions

7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 mRNA]; 7-hydroxycoumarin inhibits the reaction [Streptozocin results in increased expression of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

mitogen activated protein kinase 1

multiple interactions

7-hydroxycoumarin inhibits the reaction [Glycochenodeoxycholic Acid results in increased phosphorylation of MAPK1 protein]; 7-hydroxycoumarin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G