Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:probe
go back to main search page
Accession:CHEBI:50406 term browser browse the term
Definition:A role played by a molecular entity used to study the microscopic environment.


show annotations for term's descendants           Sort by:
 
1-nitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCE1 mRNA CTD PMID:19041380 NCBI chr19:31,867,960...31,892,863
Ensembl chr19:31,867,981...31,892,863
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCF1 mRNA CTD PMID:19428942 NCBI chr20:3,309,914...3,322,828
Ensembl chr20:3,309,899...3,322,825
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO 1-nitropyrene results in increased expression of ADAMTS1 mRNA CTD PMID:19041380 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 increases expression ISO 1-nitropyrene results in increased expression of ADGRG6 mRNA CTD PMID:19041380 NCBI chr 1:8,593,342...8,751,540
Ensembl chr 1:8,593,075...8,751,198
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO ADRB2 protein promotes the reaction [1-nitropyrene results in increased secretion of CXCL8 protein] CTD PMID:24904980 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO 1-nitropyrene results in increased expression of AFF4 mRNA CTD PMID:19041380 NCBI chr10:38,692,167...38,773,021
Ensembl chr10:38,692,211...38,773,021
JBrowse link
G Aftph aftiphilin increases expression ISO 1-nitropyrene results in increased expression of AFTPH mRNA CTD PMID:19041380 NCBI chr14:104,921,633...104,975,763
Ensembl chr14:104,922,282...104,960,141
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance
ISO 1-nitropyrene binds to and results in increased activity of AHR protein; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]
AHR affects the susceptibility to 1-nitropyrene
CTD PMID:12117779, PMID:22044530, PMID:28186253 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 1-nitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17240030 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO 1-nitropyrene results in increased expression of ALCAM mRNA CTD PMID:19041380 NCBI chr11:50,780,735...50,985,083
Ensembl chr11:50,781,127...50,985,083
JBrowse link
G Ang angiogenin decreases expression ISO 1-nitropyrene results in decreased expression of ANG mRNA CTD PMID:19041380 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO 1-nitropyrene results in increased expression of ANTXR2 mRNA CTD PMID:19041380 NCBI chr14:13,191,716...13,331,286
Ensembl chr14:13,192,347...13,274,978
JBrowse link
G Apcdd1 APC down-regulated 1 decreases expression ISO 1-nitropyrene results in decreased expression of APCDD1 mRNA CTD PMID:19041380 NCBI chr18:58,270,398...58,300,982
Ensembl chr18:58,270,410...58,301,002
JBrowse link
G Ar androgen receptor multiple interactions ISO 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO 1-nitropyrene results in increased expression of ARFIP1 mRNA CTD PMID:19041380 NCBI chr 2:183,503,250...183,582,798
Ensembl chr 2:183,504,330...183,582,553
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO 1-nitropyrene results in increased expression of ASNS mRNA CTD PMID:19041380 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atg7 autophagy related 7 multiple interactions
affects response to substance
increases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
ATG7 protein affects the susceptibility to 1-nitropyrene
1-nitropyrene results in increased expression of ATG7 mRNA; 1-nitropyrene results in increased expression of ATG7 protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:29078374 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of ATP5H mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5H mRNA]
CTD PMID:29078374 NCBI chr10:103,967,340...103,972,552
Ensembl chr10:103,967,312...103,972,668
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO 1-nitropyrene results in increased expression of ATP8B1 mRNA CTD PMID:19041380 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of BAD protein CTD PMID:17240030 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of BAX mRNA
TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]
CTD PMID:10837373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 1-nitropyrene results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 1-nitropyrene results in decreased expression of BCL2L1 protein CTD PMID:17240030 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO 1-nitropyrene results in increased expression of BID protein CTD PMID:17240030 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO 1-nitropyrene results in increased expression of BIRC3 mRNA CTD PMID:21540303 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO 1-nitropyrene results in increased expression of BMP2 mRNA CTD PMID:21540303 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO 1-nitropyrene results in increased expression of BMPER mRNA CTD PMID:19041380 NCBI chr 8:24,369,916...24,615,484
Ensembl chr 8:24,369,916...24,615,479
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO 1-nitropyrene results in decreased expression of BRCA1 mRNA CTD PMID:21540303 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G C1qtnf2 C1q and TNF related 2 decreases expression ISO 1-nitropyrene results in decreased expression of C1QTNF2 mRNA CTD PMID:19041380 NCBI chr10:29,067,102...29,084,035
Ensembl chr10:29,067,102...29,084,035
JBrowse link
G C1rl complement C1r subcomponent like decreases expression ISO 1-nitropyrene results in decreased expression of C1RL mRNA CTD PMID:19041380 NCBI chr 4:157,108,190...157,122,689
Ensembl chr 4:157,107,469...157,123,446
JBrowse link
G Ca6 carbonic anhydrase 6 decreases expression ISO 1-nitropyrene results in decreased expression of CA6 mRNA CTD PMID:19041380 NCBI chr 5:167,226,246...167,244,786
Ensembl chr 5:167,226,246...167,244,786
JBrowse link
G Casp2 caspase 2 increases activity ISO 1-nitropyrene results in increased activity of CASP2 protein CTD PMID:21872649 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP3 protein; methyl-beta-cyclodextrin inhibits the reaction [1-nitropyrene results in increased activity of CASP3 protein] CTD PMID:17240030, PMID:21872649 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cbs cystathionine beta synthase increases expression ISO 1-nitropyrene results in increased expression of CBS mRNA CTD PMID:19041380 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Ccdc18 coiled-coil domain containing 18 increases expression ISO 1-nitropyrene results in increased expression of CCDC18 mRNA CTD PMID:19041380 NCBI chr14:1,664,620...1,701,269
NCBI chr14:2,510,184...2,612,070
Ensembl chr14:2,509,363...2,610,929
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO 1-nitropyrene results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO 1-nitropyrene results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:58,181,025...58,182,969
Ensembl chr 5:58,181,026...58,183,017
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO 1-nitropyrene results in increased expression of CCL20 mRNA CTD PMID:19428942, PMID:19879285, PMID:21540303 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO 1-nitropyrene results in decreased expression of CCL21 mRNA CTD PMID:19428942 NCBI chr 5:58,197,678...58,198,782
Ensembl chr 5:58,197,680...58,198,782
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO 1-nitropyrene results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 decreases expression ISO 1-nitropyrene results in decreased expression of CCL26 mRNA CTD PMID:19428942 NCBI chr12:24,157,182...24,161,870
Ensembl chr12:24,158,766...24,161,869
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 1-nitropyrene results in increased expression of CCL5 mRNA CTD PMID:19879285 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO 1-nitropyrene results in increased expression of CCN2 mRNA CTD PMID:19041380 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 1-nitropyrene results in increased expression of CCND1 mRNA CTD PMID:19041380 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO 1-nitropyrene results in increased expression of CCR4 mRNA CTD PMID:19428942 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO 1-nitropyrene results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO 1-nitropyrene results in decreased expression of CCR7 mRNA CTD PMID:19428942 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO 1-nitropyrene results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456
JBrowse link
G Cd14 CD14 molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD14 mRNA CTD PMID:19041380 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd8b CD8b molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD8B1 mRNA CTD PMID:19041380 NCBI chr 4:99,185,960...99,201,887
Ensembl chr 4:99,185,885...99,202,023
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 1-nitropyrene results in decreased expression of CDH1 mRNA CTD PMID:19041380 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh13 cadherin 13 increases expression ISO 1-nitropyrene results in increased expression of CDH13 mRNA CTD PMID:19041380 NCBI chr19:50,848,793...51,971,618
Ensembl chr19:50,848,736...51,972,103
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO 1-nitropyrene results in decreased expression of CDH3 mRNA CTD PMID:19041380 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdk17 cyclin-dependent kinase 17 increases expression ISO 1-nitropyrene results in increased expression of CDK17 mRNA CTD PMID:19041380 NCBI chr 7:34,001,506...34,088,418
Ensembl chr 7:34,001,506...34,079,616
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
1-nitropyrene results in increased expression of CDKN1A mRNA; 1-nitropyrene results in increased expression of CDKN1A protein
CTD PMID:21540303, PMID:22044530 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression
ISO [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein] CTD PMID:29078374 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO 1-nitropyrene results in increased expression of CEBPB mRNA CTD PMID:19428942 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO 1-nitropyrene results in decreased expression of CEBPD mRNA CTD PMID:19041380 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO 1-nitropyrene results in increased expression of CEBPG mRNA CTD PMID:19041380 NCBI chr 1:91,286,956...91,297,459
Ensembl chr 1:91,287,917...91,296,656
JBrowse link
G Cenpb centromere protein B decreases expression ISO 1-nitropyrene results in decreased expression of CENPB mRNA CTD PMID:19041380 NCBI chr 3:123,720,888...123,723,520
Ensembl chr 3:123,721,486...123,723,524
JBrowse link
G Clu clusterin decreases expression ISO 1-nitropyrene results in decreased expression of CLU mRNA CTD PMID:19041380 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of COMMD3 mRNA CTD PMID:19041380 NCBI chr17:85,356,042...85,359,835
Ensembl chr17:85,356,042...85,359,833
JBrowse link
G Coro1c coronin 1C increases expression ISO 1-nitropyrene results in increased expression of CORO1C mRNA CTD PMID:19041380 NCBI chr12:48,481,741...48,554,054
Ensembl chr12:48,481,750...48,554,052
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 1-nitropyrene results in increased expression of CSF2 mRNA CTD PMID:21540303 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO 1-nitropyrene results in increased expression of CTH mRNA CTD PMID:19041380 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380, PMID:19428942, PMID:19879285 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO 1-nitropyrene results in increased expression of CXCL10 mRNA CTD PMID:19428942, PMID:19879285 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 1-nitropyrene results in increased expression of CXCL11 mRNA CTD PMID:19428942, PMID:19879285 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 1-nitropyrene results in increased expression of CXCL2 mRNA CTD PMID:19041380 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380, PMID:19428942, PMID:19879285 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL6 mRNA CTD PMID:19428942 NCBI chr14:18,860,201...18,920,839
Ensembl chr14:18,860,264...18,862,407
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO 1-nitropyrene results in decreased expression of CXCR2 mRNA CTD PMID:19428942 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases degradation
multiple interactions
increases stability
increases expression
ISO
EXP
1-nitropyrene results in increased degradation of CYP1A1 protein
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]
1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 protein
1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]
CTD PMID:12117779, PMID:16280210, PMID:17240030, PMID:18493746, PMID:19961161, PMID:22044530 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects response to substance
multiple interactions
ISO
EXP
CYP1A2 affects the susceptibility to 1-nitropyrene
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene]
CTD PMID:10727902, PMID:18493746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
ISO 1-nitropyrene results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of 1-nitropyrene
CTD PMID:11525925, PMID:12117779, PMID:21887816 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 1-nitropyrene results in increased expression of DDIT3 mRNA CTD PMID:19041380 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO 1-nitropyrene results in increased expression of DKK1 mRNA CTD PMID:19041380 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression ISO 1-nitropyrene results in increased expression of DLC1 mRNA CTD PMID:19041380 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 increases expression ISO 1-nitropyrene results in increased expression of DMTF1 mRNA CTD PMID:19041380 NCBI chr 4:21,862,297...21,902,798
Ensembl chr 4:21,862,313...21,902,762
JBrowse link
G Dner delta/notch-like EGF repeat containing increases expression ISO 1-nitropyrene results in increased expression of DNER mRNA CTD PMID:19041380 NCBI chr 9:91,965,866...92,291,172
Ensembl chr 9:91,965,866...92,291,220
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 1-nitropyrene results in increased expression of DUSP10 mRNA CTD PMID:19041380 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO 1-nitropyrene results in increased expression of DUSP6 mRNA CTD PMID:19041380 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egr1 early growth response 1 increases expression ISO 1-nitropyrene results in increased expression of EGR1 mRNA CTD PMID:21540303 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO 1-nitropyrene results in increased expression of EHHADH mRNA CTD PMID:19041380 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of EIF4EBP1 mRNA CTD PMID:19041380 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Ereg epiregulin increases expression ISO 1-nitropyrene results in increased expression of EREG mRNA CTD PMID:21887816 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Esm1 endothelial cell-specific molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ESM1 mRNA CTD PMID:19041380 NCBI chr 2:45,104,392...45,113,130
Ensembl chr 2:45,104,305...45,113,131
JBrowse link
G Etv5 ETS variant transcription factor 5 increases expression ISO 1-nitropyrene results in increased expression of ETV5 mRNA CTD PMID:19041380 NCBI chr11:82,194,657...82,252,145
Ensembl chr11:82,194,657...82,252,139
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO 1-nitropyrene results in increased expression of EVI2A mRNA CTD PMID:19041380 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948
JBrowse link
G Exoc5 exocyst complex component 5 increases expression ISO 1-nitropyrene results in increased expression of EXOC5 mRNA CTD PMID:19041380 NCBI chr15:25,888,757...25,933,302
Ensembl chr15:25,887,070...25,933,268
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-nitropyrene results in increased expression of F3 mRNA CTD PMID:19041380 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO 1-nitropyrene results in increased expression of FGF5 mRNA CTD PMID:19041380 NCBI chr14:12,974,921...12,996,046
Ensembl chr14:12,974,921...12,995,584
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of FOS mRNA CTD PMID:21540303 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO 1-nitropyrene results in increased expression of G0S2 mRNA CTD PMID:19041380 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G Gars glycyl-tRNA synthetase increases expression ISO 1-nitropyrene results in increased expression of GARS1 mRNA CTD PMID:19041380 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO 1-nitropyrene results in decreased expression of GAS1 mRNA CTD PMID:19041380 NCBI chr17:4,846,116...4,849,350
Ensembl chr17:4,846,789...4,847,940
JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of GBP2 mRNA CTD PMID:19041380 NCBI chr 2:248,276,795...248,293,784
Ensembl chr 2:248,276,709...248,293,784
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 increases expression ISO 1-nitropyrene results in increased expression of GDAP1 mRNA CTD PMID:19041380 NCBI chr 5:1,328,963...1,347,946
Ensembl chr 5:1,328,913...1,347,921
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO 1-nitropyrene results in increased expression of GLIPR1 mRNA CTD PMID:19041380 NCBI chr 7:54,767,828...54,778,823
Ensembl chr 7:54,767,827...54,778,848
JBrowse link
G Golga4 golgin A4 increases expression ISO 1-nitropyrene results in increased expression of GOLGA4 mRNA CTD PMID:19041380 NCBI chr 8:127,171,221...127,248,938
Ensembl chr 8:127,171,537...127,248,538
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO 1-nitropyrene results in increased expression of GPT2 mRNA CTD PMID:19041380 NCBI chr19:22,599,003...22,633,529
Ensembl chr19:22,590,881...22,632,071
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO 1-nitropyrene results in increased expression of GREM1 mRNA CTD PMID:19041380 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Gsdmc gasdermin C decreases expression ISO 1-nitropyrene results in decreased expression of GSDMC mRNA CTD PMID:19041380 NCBI chr 7:104,474,418...104,492,373
Ensembl chr 7:104,474,418...104,486,710
JBrowse link
G Habp2 hyaluronan binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of HABP2 mRNA CTD PMID:19041380 NCBI chr 1:277,068,715...277,104,567
Ensembl chr 1:277,068,761...277,104,566
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 1-nitropyrene results in increased expression of HBEGF mRNA CTD PMID:19041380 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 1-nitropyrene results in increased expression of HIF1A mRNA CTD PMID:19041380 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO 1-nitropyrene results in increased expression of HMGA2 mRNA CTD PMID:19041380 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1-nitropyrene results in increased expression of HMOX1 protein CTD PMID:28633978 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene] CTD PMID:10727902 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749
JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression
increases expression
EXP
ISO
1-nitropyrene affects the expression of HRAS mRNA
1-nitropyrene results in increased expression of HRAS mRNA
CTD PMID:9891514, PMID:11201684, PMID:11911274 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of HSPA5 protein
Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]
CTD PMID:19460413 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of IARS1 mRNA CTD PMID:19041380 NCBI chr17:15,356,016...15,402,680
Ensembl chr17:15,355,529...15,402,649
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ICAM1 mRNA CTD PMID:21540303 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO 1-nitropyrene results in increased expression of IFRD1 mRNA CTD PMID:19041380 NCBI chr 6:60,132,025...60,151,354
Ensembl chr 6:60,132,024...60,151,420
JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO 1-nitropyrene results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:31,560,301...31,582,457
Ensembl chr11:31,560,530...31,582,457
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-nitropyrene results in increased expression of IL1A mRNA CTD PMID:19428942, PMID:21540303 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1-nitropyrene results in increased secretion of IL1B protein CTD PMID:19041380 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO 1-nitropyrene results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:1,385,256...1,392,275
Ensembl chr 3:1,385,654...1,392,275
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions
ISO 1-nitropyrene results in increased expression of IL6 mRNA
1-nitropyrene results in increased secretion of IL6 protein
3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:19041380, PMID:19879285, PMID:29078374 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha increases expression ISO 1-nitropyrene results in increased expression of INA mRNA CTD PMID:19041380 NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO 1-nitropyrene results in increased expression of INHBB mRNA CTD PMID:19041380 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B increases expression ISO 1-nitropyrene results in increased expression of INPP4B mRNA CTD PMID:19041380 NCBI chr19:29,592,889...30,341,528
Ensembl chr19:29,597,905...29,968,424
JBrowse link
G Ipo7 importin 7 increases expression ISO 1-nitropyrene results in increased expression of IPO7 mRNA CTD PMID:19041380 NCBI chr 1:174,655,939...174,696,173
Ensembl chr 1:174,655,939...174,696,173
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO 1-nitropyrene results in increased expression of IRF1 mRNA CTD PMID:21540303 NCBI chr10:39,109,530...39,116,532
Ensembl chr10:39,109,522...39,116,531
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO 1-nitropyrene results in decreased expression of ITGB4 mRNA CTD PMID:19041380 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of JUN mRNA CTD PMID:21540303 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kctd15 potassium channel tetramerization domain containing 15 increases expression ISO 1-nitropyrene results in increased expression of KCTD15 mRNA CTD PMID:19041380 NCBI chr 1:90,506,697...90,522,217
Ensembl chr 1:90,506,697...90,520,344
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases mutagenesis
ISO [1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene; [1-nitropyrene co-treated with Polychlorinated Biphenyls] results in increased mutagenesis of KRAS gene; [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene
1-nitropyrene results in increased mutagenesis of KRAS gene
CTD PMID:9726818, PMID:10396879, PMID:11746253, PMID:12616606 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt34 keratin 34 increases expression ISO 1-nitropyrene results in increased expression of KRT34 mRNA CTD PMID:19041380 NCBI chr10:87,950,364...87,954,055
Ensembl chr10:87,950,001...87,954,055
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor increases expression ISO 1-nitropyrene results in increased expression of LCOR mRNA CTD PMID:19041380 NCBI chr 1:260,775,091...260,839,549
Ensembl chr 1:260,732,485...260,830,854
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO 1-nitropyrene results in increased expression of LIG4 mRNA CTD PMID:19041380 NCBI chr16:85,331,771...85,339,496
Ensembl chr16:85,331,866...85,337,769
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO 1-nitropyrene results in increased expression of LMAN1 mRNA CTD PMID:19041380 NCBI chr18:61,683,377...61,707,344
Ensembl chr18:61,685,117...61,707,317
JBrowse link
G Lrrc17 leucine rich repeat containing 17 decreases expression ISO 1-nitropyrene results in decreased expression of LRRC17 mRNA CTD PMID:19041380 NCBI chr 4:10,108,184...10,138,652
Ensembl chr 4:10,108,192...10,138,652
JBrowse link
G Lta lymphotoxin alpha decreases expression ISO 1-nitropyrene results in decreased expression of LTA mRNA CTD PMID:19428942 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ltb lymphotoxin beta increases expression ISO 1-nitropyrene results in increased expression of LTB mRNA CTD PMID:19428942, PMID:19879285 NCBI chr20:5,184,631...5,186,476
Ensembl chr20:5,184,515...5,186,503
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression ISO 1-nitropyrene results in increased expression of LURAP1L mRNA CTD PMID:19041380 NCBI chr 5:98,468,039...98,515,126
Ensembl chr 5:98,469,047...98,515,125
JBrowse link
G Mak16 MAK16 homolog increases expression ISO 1-nitropyrene results in increased expression of MAK16 mRNA CTD PMID:19041380 NCBI chr16:64,729,254...64,737,807
Ensembl chr16:64,729,221...64,737,807
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MAP1LC3B mRNA; 1-nitropyrene results in increased expression of MAP1LC3B protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]
CTD PMID:29078374 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK1 protein CTD PMID:17240030 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK3 protein CTD PMID:17240030 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression ISO 1-nitropyrene results in increased expression of MAPK6 mRNA CTD PMID:19041380 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK8 protein CTD PMID:17240030 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of MARS1 mRNA CTD PMID:19041380 NCBI chr 7:70,585,011...70,602,425
Ensembl chr 7:70,585,013...70,602,310
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MDM2 mRNA; 1-nitropyrene results in increased expression of MDM2 protein; 1-nitropyrene results in increased expression of MDM2 protein modified form
nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373, PMID:22044530 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mettl7a methyltransferase like 7A decreases expression ISO 1-nitropyrene results in decreased expression of METTL7A mRNA CTD PMID:19041380 NCBI chr 7:141,973,447...142,021,344
Ensembl chr 7:141,973,553...141,981,432
JBrowse link
G Mlph melanophilin increases expression ISO 1-nitropyrene results in increased expression of MLPH mRNA CTD PMID:19041380 NCBI chr 9:98,072,965...98,108,429
Ensembl chr 9:98,073,038...98,108,433
JBrowse link
G Mob4 MOB family member 4, phocein increases expression ISO 1-nitropyrene results in increased expression of MOB4 mRNA CTD PMID:19041380 NCBI chr 9:61,720,583...61,744,532
Ensembl chr 9:61,720,583...61,744,531
JBrowse link
G Mocos molybdenum cofactor sulfurase increases expression ISO 1-nitropyrene results in increased expression of MOCOS mRNA CTD PMID:19041380 NCBI chr18:16,590,086...16,636,312
Ensembl chr18:16,590,197...16,636,084
JBrowse link
G Mospd1 motile sperm domain containing 1 increases expression ISO 1-nitropyrene results in increased expression of MOSPD1 mRNA CTD PMID:19041380 NCBI chr  X:157,745,939...157,774,505
Ensembl chr  X:157,759,624...157,773,108
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO 1-nitropyrene results in increased expression of MTHFD1L mRNA CTD PMID:19041380 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
G Mtmr2 myotubularin related protein 2 increases expression ISO 1-nitropyrene results in increased expression of MTMR2 mRNA CTD PMID:19041380 NCBI chr 8:12,283,471...12,334,014
Ensembl chr 8:12,284,528...12,333,316
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1-nitropyrene results in increased expression of MYC mRNA CTD PMID:10928071 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFA1 mRNA
1-nitropyrene results in decreased expression of NDUFA1 mRNA; 1-nitropyrene results in decreased expression of NDUFA1 protein
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
CTD PMID:29078374 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions
decreases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
1-nitropyrene results in decreased expression of NDUFA2 mRNA; 1-nitropyrene results in decreased expression of NDUFA2 protein
CTD PMID:29078374 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions
decreases expression
ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA] CTD PMID:29078374 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFS4 mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]
CTD PMID:29078374 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 1-nitropyrene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28633978 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
increases activity
ISO 1-nitropyrene results in increased expression of NFKB1 mRNA
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]
CTD PMID:12393170, PMID:21540303 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased expression of CXCL8 mRNA] CTD PMID:12393170 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Noc3l NOC3-like DNA replication regulator increases expression ISO 1-nitropyrene results in increased expression of NOC3L mRNA CTD PMID:19041380 NCBI chr 1:257,469,538...257,498,844
Ensembl chr 1:257,469,538...257,498,844
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO 1-nitropyrene results in increased expression of NRG1 mRNA CTD PMID:19041380 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO 1-nitropyrene results in increased expression of NT5E mRNA CTD PMID:19041380 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Ntn3 netrin 3 decreases expression ISO 1-nitropyrene results in decreased expression of NTN3 mRNA CTD PMID:19041380 NCBI chr10:13,577,725...13,580,821
Ensembl chr10:13,577,725...13,580,821
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO 1-nitropyrene results in decreased expression of OAS1 mRNA CTD PMID:19041380 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression ISO 1-nitropyrene results in increased expression of OASL mRNA CTD PMID:19041380 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Osbpl6 oxysterol binding protein-like 6 increases expression ISO 1-nitropyrene results in increased expression of OSBPL6 mRNA CTD PMID:19041380 NCBI chr 3:63,257,646...63,455,105
Ensembl chr 3:63,353,178...63,454,967
JBrowse link
G Oxr1 oxidation resistance 1 increases expression ISO 1-nitropyrene results in increased expression of OXR1 mRNA CTD PMID:19041380 NCBI chr 7:80,351,774...80,788,094
Ensembl chr 7:80,351,774...80,788,094
JBrowse link
G Pcdhb8 protocadherin beta 8 decreases expression ISO 1-nitropyrene results in decreased expression of PCDHB5 mRNA CTD PMID:19041380 NCBI chr18:30,435,119...30,437,458
Ensembl chr18:30,435,119...30,437,458
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO 1-nitropyrene results in increased expression of PCK2 mRNA CTD PMID:19041380 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRB mRNA CTD PMID:19041380 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Pdgfrl platelet-derived growth factor receptor-like decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRL mRNA CTD PMID:19041380 NCBI chr16:54,386,269...54,450,426
Ensembl chr16:54,386,288...54,450,426
JBrowse link
G Pdpn podoplanin decreases expression ISO 1-nitropyrene results in decreased expression of PDPN mRNA CTD PMID:19041380 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO 1-nitropyrene results in increased expression of PICALM mRNA CTD PMID:19041380 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO 1-nitropyrene results in increased expression of PIK3C2A mRNA CTD PMID:19041380 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pir pirin decreases expression ISO 1-nitropyrene results in decreased expression of PIR mRNA CTD PMID:19041380 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 decreases expression ISO 1-nitropyrene results in decreased expression of PLEKHB1 mRNA CTD PMID:19041380 NCBI chr 1:165,665,905...165,683,753
Ensembl chr 1:165,665,909...165,680,206
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of POLA1 mRNA CTD PMID:19041380 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Polr2e RNA polymerase II, I and III subunit E decreases expression ISO 1-nitropyrene results in decreased expression of POLR2E mRNA CTD PMID:19041380 NCBI chr 7:12,532,785...12,536,797
Ensembl chr 7:12,532,895...12,536,791
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO 1-nitropyrene results in increased expression of PRKAA1 mRNA CTD PMID:19041380 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha increases expression ISO 1-nitropyrene results in increased expression of PRKAR1A mRNA CTD PMID:19041380 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkch protein kinase C, eta increases expression ISO 1-nitropyrene results in increased expression of PRKCH mRNA CTD PMID:19041380 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of PRKDC protein CTD PMID:28633978 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Prmt3 protein arginine methyltransferase 3 increases expression ISO 1-nitropyrene results in increased expression of PRMT3 mRNA CTD PMID:19041380 NCBI chr 1:105,113,595...105,200,253
Ensembl chr 1:105,113,595...105,200,470
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO 1-nitropyrene results in increased expression of PSAT1 mRNA CTD PMID:19041380 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression ISO 1-nitropyrene results in decreased expression of PSMB9 mRNA CTD PMID:19041380 NCBI chr20:3,973,424...3,978,845
Ensembl chr20:3,973,420...3,978,845
JBrowse link
G Psmd5 proteasome 26S subunit, non-ATPase 5 increases expression ISO 1-nitropyrene results in increased expression of PSMD5 mRNA CTD PMID:19041380 NCBI chr 3:13,916,199...13,937,031
Ensembl chr 3:13,916,203...13,933,658
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO 1-nitropyrene results in increased expression of PSME4 mRNA CTD PMID:19041380 NCBI chr14:115,166,165...115,269,041
Ensembl chr14:115,166,416...115,269,056
JBrowse link
G Ptcd2 pentatricopeptide repeat domain 2 increases expression ISO 1-nitropyrene results in increased expression of PTCD2 mRNA CTD PMID:19041380 NCBI chr 2:29,570,581...29,598,328
Ensembl chr 2:29,570,538...29,598,277
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 1-nitropyrene results in increased expression of PTHLH mRNA CTD PMID:19041380 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Ptn pleiotrophin decreases expression ISO 1-nitropyrene results in decreased expression of PTN mRNA CTD PMID:19041380 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B increases expression ISO 1-nitropyrene results in increased expression of PTPRB mRNA CTD PMID:19041380 NCBI chr 7:59,326,484...59,431,114
Ensembl chr 7:59,326,518...59,425,718
JBrowse link
G Rab20 RAB20, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB20 mRNA CTD PMID:19041380 NCBI chr16:83,358,116...83,382,326
Ensembl chr16:83,358,116...83,382,326
JBrowse link
G Rab26 RAB26, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB26 mRNA CTD PMID:19041380 NCBI chr10:13,894,271...13,898,578
Ensembl chr10:13,893,290...13,898,855
JBrowse link
G Rab34 RAB34, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB34 mRNA CTD PMID:19041380 NCBI chr10:65,448,111...65,452,178
Ensembl chr10:65,448,950...65,452,177
JBrowse link
G Ramp1 receptor activity modifying protein 1 decreases expression ISO 1-nitropyrene results in decreased expression of RAMP1 mRNA CTD PMID:19041380 NCBI chr 9:98,313,632...98,364,206
Ensembl chr 9:98,313,632...98,364,205
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression ISO 1-nitropyrene results in increased expression of RANBP6 mRNA CTD PMID:19041380 NCBI chr 1:247,980,976...247,985,553
Ensembl chr 1:247,982,180...247,985,497
JBrowse link
G Rasa2 RAS p21 protein activator 2 increases expression ISO 1-nitropyrene results in increased expression of RASA2 mRNA CTD PMID:19041380 NCBI chr 8:104,417,827...104,542,313
Ensembl chr 8:104,414,567...104,542,317
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO 1-nitropyrene results in increased activity of RELA protein
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]
CTD PMID:12393170 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1306227 similar to 4833420G17Rik protein increases expression ISO 1-nitropyrene results in increased expression of C5ORF34 mRNA CTD PMID:19041380 NCBI chr 2:52,333,396...52,355,044
Ensembl chr 2:52,333,396...52,355,042
JBrowse link
G Riox2 ribosomal oxygenase 2 increases expression ISO 1-nitropyrene results in increased expression of RIOX2 mRNA CTD PMID:19041380 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO 1-nitropyrene results in increased expression of RND3 mRNA CTD PMID:19041380 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Sacs sacsin molecular chaperone increases expression ISO 1-nitropyrene results in increased expression of SACS mRNA CTD PMID:19041380 NCBI chr15:41,448,078...41,530,412
Ensembl chr15:41,448,064...41,530,398
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
decreases response to substance
ISO 1-nitropyrene results in decreased expression of SCD1 mRNA; 1-nitropyrene results in decreased expression of SCD1 protein
SCD1 protein results in decreased susceptibility to 1-nitropyrene
CTD PMID:21872649 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression ISO 1-nitropyrene results in decreased expression of SCNN1A mRNA CTD PMID:19041380 NCBI chr 4:157,834,339...157,860,472
Ensembl chr 4:157,836,912...157,860,049
JBrowse link
G Sectm1b secreted and transmembrane 1B decreases expression ISO 1-nitropyrene results in decreased expression of SECTM1 mRNA CTD PMID:19041380 NCBI chr10:110,251,363...110,260,577
Ensembl chr10:110,251,363...110,259,985
JBrowse link
G Sele selectin E increases expression ISO 1-nitropyrene results in increased expression of SELE mRNA CTD PMID:21540303 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO 1-nitropyrene results in increased expression of SERPINB8 mRNA CTD PMID:19041380 NCBI chr13:27,876,662...27,914,038
Ensembl chr13:27,889,345...27,914,006
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO 1-nitropyrene results in increased expression of SERPINE1 mRNA CTD PMID:19041380 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of SH3KBP1 mRNA CTD PMID:19041380 NCBI chr  X:37,790,004...38,196,365
Ensembl chr  X:37,790,586...38,196,204
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 increases expression ISO 1-nitropyrene results in increased expression of SH3RF1 mRNA CTD PMID:19041380 NCBI chr16:32,062,425...32,227,526
Ensembl chr16:32,062,336...32,227,491
JBrowse link
G Slmap sarcolemma associated protein increases expression ISO 1-nitropyrene results in increased expression of SLMAP mRNA CTD PMID:19041380 NCBI chr16:2,112,271...2,227,336
Ensembl chr16:2,112,274...2,227,309
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 increases expression ISO 1-nitropyrene results in increased expression of SMURF2 mRNA CTD PMID:19041380 NCBI chr10:95,018,050...95,118,107
Ensembl chr10:95,018,059...95,062,987
JBrowse link
G Snca synuclein alpha decreases expression ISO 1-nitropyrene results in decreased expression of SNCA mRNA CTD PMID:19041380 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Snx14 sorting nexin 14 increases expression ISO 1-nitropyrene results in increased expression of SNX14 mRNA CTD PMID:19041380 NCBI chr 8:96,018,943...96,088,405
Ensembl chr 8:96,023,445...96,088,405
JBrowse link
G Sox21 SRY-box transcription factor 21 decreases expression ISO 1-nitropyrene results in decreased expression of SOX21 mRNA CTD PMID:19041380 NCBI chr15:103,438,674...103,441,405
Ensembl chr15:103,440,212...103,441,030
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 1-nitropyrene results in decreased expression of SPP1 mRNA CTD PMID:19428942 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO 1-nitropyrene results in increased expression of STC2 mRNA CTD PMID:19041380 NCBI chr10:16,542,909...16,552,675
Ensembl chr10:16,542,882...16,553,295
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO 1-nitropyrene results in decreased expression of TACSTD2 mRNA CTD PMID:19041380 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
JBrowse link
G Tagln transgelin increases expression ISO 1-nitropyrene results in increased expression of TAGLN mRNA CTD PMID:19041380 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of TARS1 mRNA CTD PMID:19041380 NCBI chr 2:61,394,632...61,414,115
Ensembl chr 2:61,394,770...61,414,102
JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of TAX1BP1 mRNA CTD PMID:19041380 NCBI chr 4:82,776,720...82,832,586
Ensembl chr 4:82,776,746...82,833,773
JBrowse link
G Thbd thrombomodulin increases expression ISO 1-nitropyrene results in increased expression of THBD mRNA CTD PMID:19041380 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene CTD PMID:23458896 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tmpo thymopoietin increases expression ISO 1-nitropyrene results in increased expression of TMPO mRNA CTD PMID:19041380 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO 1-nitropyrene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]
1-nitropyrene results in increased secretion of TNF protein
CTD PMID:19041380, PMID:19428942, PMID:19879285, PMID:21540303, PMID:28633978 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnpo1 transportin 1 increases expression ISO 1-nitropyrene results in increased expression of TNPO1 mRNA CTD PMID:19041380 NCBI chr 2:29,056,219...29,126,882
Ensembl chr 2:29,056,219...29,121,104
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO 1-nitropyrene results in increased expression of TOP1 mRNA CTD PMID:19041380 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top2b DNA topoisomerase II beta increases expression ISO 1-nitropyrene results in increased expression of TOP2B mRNA CTD PMID:19041380 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
decreases expression
affects localization
affects response to substance
affects expression
multiple interactions
ISO
EXP
1-nitropyrene results in increased expression of TP53 protein; 1-nitropyrene results in increased expression of TP53 protein modified form
1-nitropyrene results in increased phosphorylation of TRP53 protein
1-nitropyrene results in decreased expression of TRP53 mRNA
1-nitropyrene results in increased expression of TRP53 mRNA
1-nitropyrene affects the localization of TRP53 protein
TP53 affects the susceptibility to 1-nitropyrene
1-nitropyrene affects the expression of TP53 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373, PMID:10928071, PMID:11201684, PMID:11911274, PMID:17240030, PMID:22044530 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 1-nitropyrene results in increased expression of TRIB3 mRNA CTD PMID:19041380 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim23 tripartite motif-containing 23 increases expression ISO 1-nitropyrene results in increased expression of TRIM23 mRNA CTD PMID:19041380 NCBI chr 2:34,255,300...34,288,140
Ensembl chr 2:34,255,305...34,288,139
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO 1-nitropyrene results in increased expression of TRPM7 mRNA CTD PMID:19041380 NCBI chr 3:119,258,189...119,347,084
Ensembl chr 3:119,259,467...119,330,345
JBrowse link
G Trub1 TruB pseudouridine synthase family member 1 increases expression ISO 1-nitropyrene results in increased expression of TRUB1 mRNA CTD PMID:19041380 NCBI chr 1:278,311,362...278,418,347
Ensembl chr 1:278,311,244...278,418,336
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B increases expression ISO 1-nitropyrene results in increased expression of UBASH3B mRNA CTD PMID:19041380 NCBI chr 8:45,224,053...45,375,450
Ensembl chr 8:45,223,992...45,375,435
JBrowse link
G Usp15 ubiquitin specific peptidase 15 increases expression ISO 1-nitropyrene results in increased expression of USP15 mRNA CTD PMID:19041380 NCBI chr 7:66,595,707...66,687,707
Ensembl chr 7:66,595,742...66,687,278
JBrowse link
G Vcan versican increases expression ISO 1-nitropyrene results in increased expression of VCAN mRNA CTD PMID:19041380 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Virma vir like m6A methyltransferase associated increases expression ISO 1-nitropyrene results in increased expression of VIRMA mRNA CTD PMID:19041380 NCBI chr 5:25,042,743...25,121,403
Ensembl chr 5:25,042,710...25,120,264
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of WARS1 mRNA CTD PMID:19041380 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Wdfy3 WD repeat and FYVE domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of WDFY3 mRNA CTD PMID:19041380 NCBI chr14:9,169,409...9,384,835
Ensembl chr14:9,141,512...9,381,870
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO 1-nitropyrene results in increased expression of WNT2 mRNA CTD PMID:21540303 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO 1-nitropyrene results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:132,911,474...132,919,110
Ensembl chr 8:132,911,486...132,919,110
JBrowse link
G Xpot exportin for tRNA increases expression ISO 1-nitropyrene results in increased expression of XPOT mRNA CTD PMID:19041380 NCBI chr 7:63,688,646...63,728,988
Ensembl chr 7:63,690,053...63,728,988
JBrowse link
G Zdhhc11 zinc finger, DHHC-type containing 11 increases expression ISO 1-nitropyrene results in increased expression of ZDHHC11 mRNA CTD PMID:19041380 NCBI chr 1:31,906,049...31,936,603
Ensembl chr 1:31,906,064...31,936,537
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO 1-nitropyrene results in increased expression of ZEB1 mRNA CTD PMID:19041380 NCBI chr17:54,656,627...54,714,920
Ensembl chr17:54,658,463...54,714,914
JBrowse link
G Zfp62 zinc finger protein 62 increases expression ISO 1-nitropyrene results in increased expression of ZFP62 mRNA CTD PMID:19041380 NCBI chr10:34,477,108...34,493,941
Ensembl chr10:34,489,940...34,493,088
JBrowse link
4-methylumbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects export ISO ABCG2 protein affects the export of Hymecromone analog CTD PMID:15598971 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Cat catalase multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Hymecromone inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of Hymecromone CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions
increases metabolic processing
increases activity
increases glucuronidation
ISO [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Estradiol promotes the reaction [UGT1A1 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A1 protein]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:15378558, PMID:15593333, PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases activity
increases metabolic processing
multiple interactions
increases glucuronidation
ISO Hymecromone results in increased activity of UGT1A3 protein
UGT1A3 protein results in increased metabolism of Hymecromone
[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A3 protein]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
UGT1A3 protein results in increased glucuronidation of Hymecromone
CTD PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
increases activity
multiple interactions
increases glucuronidation
EXP
ISO
UGT1A6 gene polymorphism affects the metabolism of Hymecromone
UGT1A6 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A6 protein
[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; bisphenol A inhibits the reaction [UGT1A6 protein results in increased glucuronidation of Hymecromone]; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A6 protein]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:9429234, PMID:15802387, PMID:18214896, PMID:25393417, PMID:26875642, PMID:31812603 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of Hymecromone CTD PMID:15502008 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation
increases metabolic processing
multiple interactions
increases activity
EXP
ISO
UGT1A8 protein results in increased glucuronidation of Hymecromone
UGT1A8 protein results in increased metabolism of Hymecromone
[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A8 protein]; Propofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:15378558, PMID:15502008, PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
increases metabolic processing
increases activity
multiple interactions
ISO UGT1A9 protein results in increased glucuronidation of Hymecromone
UGT1A9 protein results in increased metabolism of Hymecromone
Hymecromone results in increased activity of UGT1A9 protein
[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT1A9 protein]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:15378558, PMID:15802387, PMID:26875642, PMID:31812603 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases glucuronidation ISO UGT2A1 protein results in increased glucuronidation of Hymecromone CTD PMID:21164388 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation
increases activity
increases metabolic processing
multiple interactions
EXP
ISO
UGT2B1 protein results in increased glucuronidation of Hymecromone
Hymecromone results in increased activity of UGT2B17 protein
UGT2B17 protein results in increased metabolism of Hymecromone
licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B17 protein]
CTD PMID:8302279, PMID:8798464, PMID:26875642 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Hymecromone CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases activity
increases metabolic processing
multiple interactions
ISO Hymecromone results in increased activity of UGT2B7 protein
UGT2B7 protein results in increased metabolism of Hymecromone
[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; licochalcone A inhibits the reaction [Hymecromone results in increased activity of UGT2B7 protein]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
CTD PMID:26875642, PMID:31812603 NCBI chr14:22,597,103...22,619,968 JBrowse link
4-methylumbelliferone beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 multiple interactions ISO [UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A8 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide] CTD PMID:31812603 NCBI chr14:22,597,103...22,619,968 JBrowse link
4-methylumbelliferone sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP 4-methylumbelliferyl sulfate inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:18441515 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
4-methylumbelliferyl beta-D-galactoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca12 carbonic anhydrase 12 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA12 protein CTD PMID:22077347 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Ca9 carbonic anhydrase 9 decreases activity ISO 4-methylumbelliferyl-galactopyranoside analog results in decreased activity of CA9 protein CTD PMID:22077347 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa glucosidase, alpha, acid multiple interactions
increases metabolic processing
ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr10:108,395,873...108,412,999
Ensembl chr10:108,395,860...108,413,059
JBrowse link
7-ethoxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing ISO CYP2E1 protein results in increased metabolism of 7-ethoxycoumarin CTD PMID:18385292 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
7-hydroxycoumarin O(7)-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases abundance EXP UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
8-anilinonaphthalene-1-sulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambp alpha-1-microglobulin/bikunin precursor affects binding ISO 1-anilino-8-naphthalenesulfonate binds to AMBP protein CTD PMID:16461020 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Apod apolipoprotein D affects binding ISO 1-anilino-8-naphthalenesulfonate binds to APOD protein CTD PMID:16461020 NCBI chr11:72,705,204...72,726,263
Ensembl chr11:72,705,129...72,726,301
JBrowse link
G C8g complement C8 gamma chain affects binding ISO 1-anilino-8-naphthalenesulfonate binds to C8G protein CTD PMID:16461020 NCBI chr 3:2,724,616...2,727,616
Ensembl chr 3:2,724,616...2,727,616
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to GSTA1 protein CTD PMID:14690442 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Lcn1 lipocalin 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN1 protein CTD PMID:16461020 NCBI chr 3:4,233,111...4,236,960
Ensembl chr 3:4,233,111...4,236,960
JBrowse link
G Lcn2 lipocalin 2 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to LCN2 protein CTD PMID:16461020 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Obp2a odorant binding protein 2A affects binding ISO 1-anilino-8-naphthalenesulfonate binds to OBP2A protein CTD PMID:16461020 NCBI chr 3:2,908,684...2,913,362
Ensembl chr 3:2,910,083...2,913,362
JBrowse link
G Orm1 orosomucoid 1 affects binding ISO 1-anilino-8-naphthalenesulfonate binds to ORM1 protein CTD PMID:16461020 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Paep progestagen associated endometrial protein affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PAEP protein CTD PMID:16461020 NCBI chr 3:2,935,396...2,938,883 JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO 1-anilino-8-naphthalenesulfonate binds to PTGDS protein CTD PMID:16461020 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Ttr transthyretin affects binding
multiple interactions
ISO 1-anilino-8-naphthalenesulfonate binds to TTR protein
3,3'-dichlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 3,4-dichlorinated biphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; 4-chlorobiphenyl metabolite inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]; Thyroxine inhibits the reaction [1-anilino-8-naphthalenesulfonate binds to TTR protein]
CTD PMID:23584369 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
auraptene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; aurapten promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ccna2 cyclin A2 affects expression ISO aurapten affects the expression of CCNA2 mRNA CTD PMID:23320178 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb2 cyclin B2 affects expression ISO aurapten affects the expression of CCNB2 mRNA CTD PMID:23320178 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cdc45 cell division cycle 45 affects expression ISO aurapten affects the expression of CDC45 mRNA CTD PMID:23320178 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects expression ISO aurapten affects the expression of CDK1 mRNA CTD PMID:23320178 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B affects expression ISO aurapten affects the expression of CDKN2B mRNA CTD PMID:23320178 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression ISO aurapten affects the expression of CDKN2C mRNA CTD PMID:23320178 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Chek1 checkpoint kinase 1 affects expression ISO aurapten affects the expression of CHEK1 mRNA CTD PMID:23320178 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 affects expression ISO aurapten affects the expression of CHEK2 mRNA CTD PMID:23320178 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression EXP aurapten results in decreased expression of CTNNB1 protein mutant form CTD PMID:16012713 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:20865247 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects expression ISO aurapten affects the expression of DDIT3 mRNA CTD PMID:23320178 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dusp1 dual specificity phosphatase 1 affects expression ISO aurapten affects the expression of DUSP1 mRNA CTD PMID:23320178 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO aurapten affects the expression of E2F1 mRNA CTD PMID:23320178 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f2 E2F transcription factor 2 affects expression ISO aurapten affects the expression of E2F2 mRNA CTD PMID:23320178 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha affects expression ISO aurapten affects the expression of GADD45A mRNA CTD PMID:23320178 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects expression ISO aurapten affects the expression of JUN mRNA CTD PMID:23320178 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kif20b kinesin family member 20B affects expression ISO aurapten affects the expression of KIF20B mRNA CTD PMID:23320178 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 affects expression ISO aurapten affects the expression of MCM3 mRNA CTD PMID:23320178 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 affects expression ISO aurapten affects the expression of MCM6 mRNA CTD PMID:23320178 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance ISO NFE2L2 protein affects the susceptibility to aurapten CTD PMID:19150646 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of PTGS2 mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] CTD PMID:20865247 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Uhrf1 ubiquitin-like with PHD and ring finger domains 1 affects expression ISO aurapten affects the expression of UHRF1 mRNA CTD PMID:23320178 NCBI chr 9:10,738,211...10,758,403
Ensembl chr 9:10,738,222...10,757,954
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO aurapten inhibits the reaction [DDT results in increased expression of VEGFA mRNA]; aurapten inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:20865247 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
carbon monoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases activity EXP Carbon Monoxide results in increased activity of ABCC2 protein CTD PMID:13678533 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein
[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein; Carbon Monoxide results in increased expression of ADIPOQ protein
CTD PMID:19356108 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adm adrenomedullin increases expression EXP Carbon Monoxide results in increased expression of ADM mRNA; Carbon Monoxide results in increased expression of ADM protein CTD PMID:10666155 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of AGR2 mRNA CTD PMID:29621558 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Agt angiotensinogen decreases response to substance ISO AGT protein results in decreased susceptibility to Carbon Monoxide CTD PMID:18174886 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein; Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207, PMID:18037988, PMID:18215737, PMID:18845810, PMID:19356108 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alad aminolevulinate dehydratase increases activity
multiple interactions
EXP Carbon Monoxide results in increased activity of ALAD protein
Carbon Monoxide inhibits the reaction [[Phenobarbital co-treated with bromobenzene] results in decreased activity of ALAD protein]
CTD PMID:1032310, PMID:6740708 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Areg amphiregulin multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of AREG mRNA CTD PMID:29621558 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Bach1 BTB domain and CNC homolog 1 decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of BACH1 protein CTD PMID:18845810 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of BAD protein] CTD PMID:18037988 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Carbon Monoxide results in decreased expression of and results in decreased secretion of BDNF protein
Carbon Monoxide results in decreased expression of BDNF mRNA
CTD PMID:27113706 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein; Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [Hemin inhibits the reaction [Carbon Monoxide results in increased cleavage of and results in increased activity of CASP3 protein]]
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP3 mRNA
Carbon Monoxide results in increased activity of CASP3 protein
CTD PMID:17173083, PMID:19356108, PMID:19520142, PMID:25562542, PMID:31268311 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity EXP Carbon Monoxide results in increased activity of CASP7 protein CTD PMID:25562542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP8 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP8 mRNA
CTD PMID:25562542, PMID:31268311 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
EXP
ISO
Carbon Monoxide results in increased activity of CASP9 protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of CASP9 mRNA
CTD PMID:25562542, PMID:31268311 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO
EXP
CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of AKT1 protein]
CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]; CAT protein inhibits the reaction [Carbon Monoxide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17179207, PMID:18845810 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of CCL1 mRNA CTD PMID:29621558 NCBI chr10:69,534,976...69,537,836
Ensembl chr10:69,534,933...69,537,882
JBrowse link
G Cd86 CD86 molecule decreases expression EXP Carbon Monoxide results in decreased expression of CD86 protein CTD PMID:12201358 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Clca1 chloride channel accessory 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CLCA1 mRNA CTD PMID:29621558 NCBI chr 2:250,897,980...250,923,711
Ensembl chr 2:250,897,969...250,923,744
JBrowse link
G Col11a1 collagen type XI alpha 1 chain multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of COL11A1 mRNA CTD PMID:29621558 NCBI chr 2:216,863,423...217,056,523
Ensembl chr 2:216,863,428...217,056,523
JBrowse link
G Crp C-reactive protein increases expression ISO Carbon Monoxide results in increased expression of CRP protein CTD PMID:18629312 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of CXCL11 mRNA CTD PMID:29621558 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP1A1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Carbon Monoxide promotes the reaction [1-ethynylpyrene results in increased expression of CYP1B1 mRNA] CTD PMID:10581206 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Carbon Monoxide inhibits the reaction [CYP2B1 protein results in increased reduction of sodium chromate(VI)] CTD PMID:1903091 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
ISO
EXP
Carbon Monoxide results in decreased activity of CYP2E1 protein
Carbon Monoxide inhibits the reaction [CYP2E1 protein results in increased reduction of sodium chromate(VI)]
CTD PMID:1903091, PMID:15036350 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Duox2 dual oxidase 2 increases expression
decreases expression
EXP Carbon Monoxide results in increased expression of DUOX2 mRNA
Carbon Monoxide results in decreased expression of DUOX2 protein
CTD PMID:29223502 NCBI chr 3:114,218,187...114,237,808
Ensembl chr 3:114,218,193...114,235,933
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
EXP
ISO
Carbon Monoxide results in increased expression of EDN1 mRNA; Carbon Monoxide results in increased expression of EDN1 protein
Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
CTD PMID:11781074, PMID:12969895, PMID:20197249 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]; Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]] CTD PMID:22046279 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Epo erythropoietin increases expression EXP Carbon Monoxide results in increased expression of EPO mRNA; Carbon Monoxide results in increased expression of EPO protein CTD PMID:9263988 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression EXP Carbon Monoxide results in increased expression of ERO1A mRNA CTD PMID:12752442 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:19750100 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO [Air Pollutants results in increased abundance of Carbon Monoxide] which results in increased methylation of FOXP3 promoter CTD PMID:29317916 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Gabpa GA binding protein transcription factor subunit alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of GABPA mRNA
Carbon Monoxide results in increased expression of GABPA protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]
CTD PMID:17179207 NCBI chr11:24,293,845...24,322,822
Ensembl chr11:24,263,281...24,322,815
JBrowse link
G Gata4 GATA binding protein 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased activity of GATA4 protein] CTD PMID:18037988 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Gpr182 G protein-coupled receptor 182 increases expression EXP Carbon Monoxide results in increased expression of GPR182 mRNA CTD PMID:10666155 NCBI chr 7:71,044,786...71,048,713
Ensembl chr 7:71,045,543...71,048,383
JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein] CTD PMID:18037988 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]
Carbon Monoxide results in increased phosphorylation of GSK3B protein
CTD PMID:18037988, PMID:18845810 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases chemical synthesis
increases expression
increases activity
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]; HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]
HMOX1 protein results in increased chemical synthesis of Carbon Monoxide
[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in increased expression of HMOX1 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; Hemin promotes the reaction [Carbon Monoxide results in increased expression of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]
CTD PMID:11880364, PMID:16365149, PMID:18037988, PMID:18845810, PMID:19520142, PMID:21444764, PMID:25348283, PMID:29165873 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
affects chemical synthesis
affects abundance
EXP Carbon Monoxide deficiency promotes the reaction [HMOX2 mutant form results in increased expression of EDN1 protein]
HMOX2 protein affects the chemical synthesis of Carbon Monoxide
HMOX2 protein affects the abundance of Carbon Monoxide
CTD PMID:11342580, PMID:12969895 NCBI chr10:10,990,034...11,035,493
Ensembl chr10:10,990,034...11,035,484
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD PMID:19356108, PMID:19608869 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IFNG protein; Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]]; Carbon Monoxide inhibits the reaction [IFNG protein results in decreased expression of HMOX1 protein] CTD PMID:16365149, PMID:29621558 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
ISO Carbon Monoxide promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; HMOX1 protein affects the reaction [Carbon Monoxide results in increased secretion of IL10 protein]
Carbon Monoxide results in increased expression of IL10 mRNA
CTD PMID:21444764 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Carbon Monoxide inhibits the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]] CTD PMID:16365149 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in decreased expression of IL13 mRNA CTD PMID:29621558 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL17A protein CTD PMID:29621558 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 decreases response to substance
multiple interactions
ISO Carbon Monoxide results in decreased susceptibility to IL18 protein
Carbon Monoxide inhibits the reaction [IL18 protein results in decreased phosphorylation of AKT1 protein]; Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein]
CTD PMID:18215737 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Carbon Monoxide results in decreased expression of IL1B protein CTD PMID:21444764 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il22 interleukin 22 multiple interactions
increases expression
ISO HMOX1 protein promotes the reaction [Carbon Monoxide results in increased expression of IL22 mRNA]; tin protoporphyrin IX inhibits the reaction [Carbon Monoxide results in increased expression of IL22 mRNA] CTD PMID:21444764 NCBI chr 7:61,236,037...61,240,502
Ensembl chr 7:61,236,037...61,240,502
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Carbon Monoxide results in decreased expression of IL4 protein
[Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of IL4 protein
CTD PMID:21444764, PMID:29621558 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of IL6 protein; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; FGB gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein]; IL6 gene SNP affects the reaction [Carbon Monoxide results in increased expression of IL6 protein] CTD PMID:18629312, PMID:19608869, PMID:19750100, PMID:31268311 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf8 interferon regulatory factor 8 decreases activity ISO Carbon Monoxide results in decreased activity of IRF8 protein CTD PMID:16365149 NCBI chr19:54,314,859...54,336,643
Ensembl chr19:54,314,865...54,336,640
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein] CTD PMID:18845810 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]] CTD PMID:11880364 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mir1224 microRNA 1224 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR1224 mRNA CTD PMID:31268311 NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
JBrowse link
G Mir186 microRNA 186 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR186 mRNA CTD PMID:31268311 NCBI chr 2:263,873,759...263,873,844
Ensembl chr 2:263,873,759...263,873,844
JBrowse link
G Mir21 microRNA 21 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR21 mRNA CTD PMID:31268311 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir342 microRNA 342 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR342 mRNA CTD PMID:31268311 NCBI chr 6:132,561,169...132,561,267
Ensembl chr 6:132,561,169...132,561,267
JBrowse link
G Mir374b microRNA 374b multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR374B mRNA CTD PMID:31268311 NCBI chr  X:74,443,648...74,443,715
Ensembl chr  X:74,443,648...74,443,715
JBrowse link
G Mir615 microRNA 615 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR615 mRNA CTD PMID:31268311 NCBI chr 7:144,629,019...144,629,110
Ensembl chr 7:144,629,019...144,629,110
JBrowse link
G Mir93 microRNA 93 multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIR93 mRNA CTD PMID:31268311 NCBI chr12:19,307,543...19,307,629
Ensembl chr12:19,307,543...19,307,629
JBrowse link
G Mirlet7i microRNA let-7i multiple interactions ISO [Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased expression of MIRLET7I mRNA CTD PMID:31268311 NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO Carbon Monoxide results in increased expression of MMP9 mRNA CTD PMID:20197249 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 mRNA]; Carbon Monoxide inhibits the reaction [Oxygen deficiency results in increased expression of NDRG1 protein] CTD PMID:11006124 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
increases localization
decreases phosphorylation
ISO
EXP
Carbon Monoxide inhibits the reaction [NFE2L2 protein binds to KEAP1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]; CAT protein inhibits the reaction [Carbon Monoxide results in increased localization of NFE2L2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased activity of HMOX1 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of NFE2L2 protein
Edaravone promotes the reaction [Carbon Monoxide results in increased expression of NFE2L2 protein]
Carbon Monoxide results in increased expression of NFE2L2 mRNA
Carbon Monoxide results in decreased phosphorylation of NFE2L2 protein
CTD PMID:18845810, PMID:25348283 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor affects expression
multiple interactions
EXP Carbon Monoxide affects the expression of NGF mRNA
Carbon Monoxide results in decreased expression of and affects the secretion of NGF protein
CTD PMID:27113706 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Carbon Monoxide results in decreased expression of NOS2 protein
CTD PMID:12201358, PMID:22046279 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein CTD PMID:19356108 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A increases expression EXP Carbon Monoxide results in increased expression of NPPA mRNA CTD PMID:11781074 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
increases expression
increases localization
ISO
EXP
AKT1 protein affects the reaction [Carbon Monoxide results in increased localization of NRF1 protein]; Carbon Monoxide promotes the reaction [NFE2L2 protein binds to NRF1 promoter]
Carbon Monoxide results in increased expression of NRF1 protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
Carbon Monoxide results in increased expression of NRF1 mRNA
CTD PMID:17179207, PMID:18845810 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ntf3 neurotrophin 3 decreases expression
multiple interactions
EXP Carbon Monoxide results in decreased expression of NTF3 mRNA
Carbon Monoxide results in decreased expression of and results in decreased secretion of NTF3 protein
CTD PMID:27113706 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression EXP [Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased expression of PECAM1 protein CTD PMID:19356108 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pla2g7 phospholipase A2 group VII affects expression ISO Carbon Monoxide affects the expression of PLA2G7 CTD PMID:21356620 NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression ISO Carbon Monoxide results in increased expression of POLG mRNA; Carbon Monoxide results in increased expression of POLG protein CTD PMID:17179207 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein; Acetylcysteine inhibits the reaction [[Carbon Monoxide results in increased abundance of Reactive Oxygen Species] which results in increased sumoylation of PPARG protein]; PPARG protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] CTD PMID:22046279 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of PPARGC1A mRNA
Carbon Monoxide results in increased expression of PPARGC1A protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein]; Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]
CTD PMID:17179207 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prg2 proteoglycan 2 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of PRG2 mRNA CTD PMID:29621558 NCBI chr 3:72,385,678...72,389,245
Ensembl chr 3:72,385,666...72,389,276
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Carbon Monoxide inhibits the reaction [IL18 protein results in increased expression of PTEN protein] CTD PMID:18215737 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Selp selectin P increases expression ISO Carbon Monoxide results in increased expression of SELP protein modified form CTD PMID:18629312 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Carbon Monoxide results in decreased expression of SOD1 protein CTD PMID:18629312 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases expression
ISO
EXP
Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Carbon Monoxide results in increased expression of SOD2 mRNA]
Carbon Monoxide results in increased expression of SOD2 protein
CTD PMID:17179207, PMID:18037988, PMID:18845810 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sostdc1 sclerostin domain containing 1 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of SOSTDC1 mRNA CTD PMID:29621558 NCBI chr 6:55,812,820...55,816,994
Ensembl chr 6:55,812,747...55,817,066
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions
ISO
EXP
Carbon Monoxide results in increased expression of TFAM mRNA; Carbon Monoxide results in increased expression of TFAM protein
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein]; Carbon Monoxide promotes the reaction [GABPA protein binds to TFAM promoter]; Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]; CAT protein inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to TFAM promoter]]
CTD PMID:17179207 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
decreases response to substance
EXP
ISO
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased activity of CASP3 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; [Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Carbon Monoxide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
Carbon monoxide decreases expression of Tnf mRNA in reperfused liver nonparenchymal cells
Carbon Monoxide results in decreased susceptibility to TNF protein
[Air Pollutants results in increased abundance of [Particulate Matter co-treated with Carbon co-treated with Sulfur Dioxide co-treated with Nitrogen Oxides co-treated with Carbon Monoxide]] which results in increased secretion of TNF protein; [HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein; [RELA protein co-treated with REL protein] inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of IL6 protein]; Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; MAPK14 protein affects the reaction [BCL2A1 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; MAPK14 protein affects the reaction [BIRC3 protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]]; RELA protein inhibits the reaction [NFKBIA protein inhibits the reaction [[HMOX1 protein results in increased chemical synthesis of Carbon Monoxide] which results in decreased susceptibility to TNF protein]]
Carbon Monoxide results in decreased expression of TNF protein
CTD PMID:11880364, PMID:17173083, PMID:19356108, PMID:19608869, PMID:21444764, PMID:31268311, PMID:18972563 RGD:15023490 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO Carbon Monoxide results in increased expression of TNFRSF1B protein modified form CTD PMID:18629312 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Tnfsf4 TNF superfamily member 4 multiple interactions ISO [Air Pollutants results in increased abundance of [Carbon Monoxide co-treated with Nitrogen Oxides co-treated with Sulfur Dioxide]] which results in increased expression of TNFSF4 mRNA CTD PMID:29621558 NCBI chr13:79,269,973...79,293,775
Ensembl chr13:79,269,973...79,293,778
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]; UCP2 protein promotes the reaction [Carbon Monoxide results in increased abundance of Reactive Oxygen Species] CTD PMID:22046279 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases phosphorylation ISO Carbon Monoxide results in decreased phosphorylation of VASP protein CTD PMID:26582457 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP
Carbon Monoxide inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
[Carbon Monoxide results in increased expression of ADIPOQ protein] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
CTD PMID:19356108, PMID:19608869 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Xdh xanthine dehydrogenase increases activity
increases metabolic processing
EXP Carbon Monoxide results in increased activity of XDH protein
Carbon Monoxide results in increased metabolism of XDH protein
CTD PMID:1447108 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity ISO Chlortetracycline results in decreased activity of CAT protein CTD PMID:30768968 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Chlortetracycline inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
coumaphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Coumaphos metabolite results in decreased activity of ACHE protein; Coumaphos results in decreased activity of ACHE protein CTD PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Coumaphos results in increased expression of GPAT3 mRNA CTD PMID:26198647 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Coumaphos results in increased expression of LIF mRNA CTD PMID:26198647 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Rara retinoic acid receptor, alpha increases activity ISO Coumaphos results in increased activity of RARA protein CTD PMID:20143881 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Coumaphos results in increased expression of SLC7A11 mRNA CTD PMID:26198647 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
filipin III term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Filipin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]
Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]
CTD PMID:12614848, PMID:17172471 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein] CTD PMID:20036696 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA] CTD PMID:29724254 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA] CTD PMID:29724254 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Des desmin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions ISO Filipin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HSPB1 protein] CTD PMID:21457723 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] CTD PMID:19632255 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; Filipin inhibits the reaction [Iron results in increased activity of [CHUK protein binds to IKBKB protein]] CTD PMID:17172471 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of JAK1 protein] CTD PMID:19632255 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein] CTD PMID:17172471 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased activity of MAP3K7 protein] CTD PMID:17172471 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein] CTD PMID:17172471 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein] CTD PMID:17172471 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein] CTD PMID:20036696 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Prnp prion protein increases secretion
decreases expression
multiple interactions
ISO Filipin results in increased secretion of PRNP protein
Filipin results in decreased expression of PRNP protein alternative form
[Copper co-treated with Filipin] results in increased cleavage of PRNP protein; Filipin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]
CTD PMID:11994310, PMID:19597535 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of SRC protein] CTD PMID:19632255 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Filipin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein] CTD PMID:19632255 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
fluorescein 5-isothiocyanate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ABCB7 protein CTD PMID:27129696 NCBI chr  X:75,150,511...75,291,950
Ensembl chr  X:75,150,608...75,291,938
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Anxa4 annexin A4 affects binding ISO Fluorescein-5-isothiocyanate binds to ANXA4 protein CTD PMID:27129696 NCBI chr 4:118,538,775...118,595,591
Ensembl chr 4:118,538,777...118,595,580
JBrowse link
G Arhgap6 Rho GTPase activating protein 6 affects binding ISO Fluorescein-5-isothiocyanate binds to ARHGAP6 protein CTD PMID:27129696 NCBI chr  X:26,314,561...26,845,242
Ensembl chr  X:26,315,878...26,376,467
JBrowse link
G Azi2 5-azacytidine induced 2 affects binding ISO Fluorescein-5-isothiocyanate binds to AZI2 protein CTD PMID:27129696 NCBI chr 8:126,411,030...126,435,581
Ensembl chr 8:126,411,829...126,434,579
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to CAPZB protein CTD PMID:27129696 NCBI chr 5:157,642,742...157,742,487
Ensembl chr 5:157,642,751...157,742,478
JBrowse link
G Cd109 CD109 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD109 protein CTD PMID:27129696 NCBI chr 8:85,951,420...86,065,411
Ensembl chr 8:85,951,191...86,065,409
JBrowse link
G Cd180 CD180 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD180 protein CTD PMID:27129696 NCBI chr 2:32,820,275...32,833,223
Ensembl chr 2:32,820,322...32,833,125
JBrowse link
G Cd86 CD86 molecule increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cd93 CD93 molecule affects binding ISO Fluorescein-5-isothiocyanate binds to CD93 protein CTD PMID:27129696 NCBI chr 3:142,778,798...142,783,774
Ensembl chr 3:142,778,770...142,783,774
JBrowse link
G Cdc20 cell division cycle 20 affects binding ISO Fluorescein-5-isothiocyanate binds to CDC20 protein CTD PMID:27129696 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Copa COPI coat complex subunit alpha affects binding ISO Fluorescein-5-isothiocyanate binds to COPA protein CTD PMID:27129696 NCBI chr13:90,467,285...90,508,894
Ensembl chr13:90,467,265...90,508,932
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 affects binding ISO Fluorescein-5-isothiocyanate binds to DCAF4 protein CTD PMID:27129696 NCBI chr 6:107,001,763...107,027,466
Ensembl chr 6:107,001,763...107,027,456
JBrowse link
G Dot1l DOT1 like histone lysine methyltransferase affects binding ISO Fluorescein-5-isothiocyanate binds to DOT1L protein CTD PMID:27129696 NCBI chr 7:11,786,105...11,824,742
Ensembl chr 7:11,786,105...11,824,742
JBrowse link
G Elac1 elaC ribonuclease Z 1 affects binding ISO Fluorescein-5-isothiocyanate binds to ELAC1 protein CTD PMID:27129696 NCBI chr18:69,706,522...69,723,869
Ensembl chr18:69,706,522...69,723,869
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 affects binding ISO Fluorescein-5-isothiocyanate binds to ENPP7 protein CTD PMID:27129696 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 affects binding ISO Fluorescein-5-isothiocyanate binds to FLRT3 protein CTD PMID:27129696 NCBI chr 3:134,684,446...134,696,586
Ensembl chr 3:134,683,065...134,696,654
JBrowse link
G Fn1 fibronectin 1 affects binding ISO Fluorescein-5-isothiocyanate binds to FN1 protein CTD PMID:27129696 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of HMOX1 protein
[Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of HMOX1 protein
CTD PMID:27871981 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA5 protein CTD PMID:27129696 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding ISO Fluorescein-5-isothiocyanate binds to HSPA9 protein CTD PMID:27129696 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IFNG protein CTD PMID:29198882 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta affects binding ISO Fluorescein-5-isothiocyanate binds to IKBKB protein CTD PMID:27129696 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikzf4 IKAROS family zinc finger 4 affects binding ISO Fluorescein-5-isothiocyanate binds to IKZF4 protein CTD PMID:27129696 NCBI chr 7:3,061,422...3,098,142
Ensembl chr 7:3,061,469...3,074,359
JBrowse link
G Il17re interleukin 17 receptor E affects binding ISO Fluorescein-5-isothiocyanate binds to IL17RE protein CTD PMID:27129696 NCBI chr 4:145,413,157...145,426,608
Ensembl chr 4:145,413,230...145,426,603
JBrowse link
G Il31ra interleukin 31 receptor A affects binding ISO Fluorescein-5-isothiocyanate binds to IL31RA protein CTD PMID:27129696 NCBI chr 2:44,333,347...44,408,005
Ensembl chr 2:44,336,006...44,394,709
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [Dibutyl Phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; [dibutyrylglycerol analog co-treated with Fluorescein-5-isothiocyanate] affects the secretion of IL4 protein; [tributyrin co-treated with Fluorescein-5-isothiocyanate] results in increased secretion of IL4 protein; diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of IL4 protein]] CTD PMID:27871981, PMID:29198882 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lypd3 Ly6/Plaur domain containing 3 affects binding ISO Fluorescein-5-isothiocyanate binds to LYPD3 protein CTD PMID:27129696 NCBI chr 1:81,499,856...81,504,306
Ensembl chr 1:81,499,821...81,504,318
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 affects binding ISO Fluorescein-5-isothiocyanate binds to MAP3K20 protein CTD PMID:27129696 NCBI chr 3:58,965,025...59,120,507
Ensembl chr 3:58,965,552...59,067,369
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK1 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK1 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:27129696 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK3 protein
Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK3 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD PMID:27129696 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK8 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK8 protein
CTD PMID:27129696 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO Fluorescein-5-isothiocyanate inhibits the reaction [Dinitrofluorobenzene results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]
Fluorescein-5-isothiocyanate results in increased phosphorylation of MAPK9 protein
CTD PMID:27129696 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mt2A metallothionein 2A increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mybpc1 myosin binding protein C1 affects binding ISO Fluorescein-5-isothiocyanate binds to MYBPC1 protein CTD PMID:27129696 NCBI chr 7:29,086,159...29,171,909
Ensembl chr 7:29,086,156...29,171,783
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO [Melatonin co-treated with diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased expression of NFE2L2 protein CTD PMID:27871981 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of NQO1 mRNA
Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein
diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]; Melatonin inhibits the reaction [diisodecyl phthalate inhibits the reaction [Fluorescein-5-isothiocyanate results in increased expression of NQO1 protein]]
CTD PMID:20491607, PMID:27871981 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Plce1 phospholipase C, epsilon 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PLCE1 protein CTD PMID:27129696 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Postn periostin affects binding ISO Fluorescein-5-isothiocyanate binds to POSTN protein CTD PMID:27129696 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Pprc1 PPARG related coactivator 1 affects binding ISO Fluorescein-5-isothiocyanate binds to PPRC1 protein CTD PMID:27129696 NCBI chr 1:265,809,892...265,826,319
Ensembl chr 1:265,809,754...265,826,306
JBrowse link
G Prkcb protein kinase C, beta increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of PRKCB protein CTD PMID:31958493 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Psd4 pleckstrin and Sec7 domain containing 4 affects binding ISO Fluorescein-5-isothiocyanate binds to PSD4 protein CTD PMID:27129696 NCBI chr 3:1,478,432...1,515,094
Ensembl chr 3:1,478,525...1,514,934
JBrowse link
G Psmd14 proteasome 26S subunit, non-ATPase 14 affects binding ISO Fluorescein-5-isothiocyanate binds to PSMD14 protein CTD PMID:27129696 NCBI chr 3:47,578,449...47,673,330
Ensembl chr 3:47,578,384...47,673,338
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein; Melatonin inhibits the reaction [[diisodecyl phthalate co-treated with Fluorescein-5-isothiocyanate] results in increased phosphorylation of RELA protein] CTD PMID:27871981 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 affects binding ISO Fluorescein-5-isothiocyanate binds to SCN5A protein CTD PMID:27129696 NCBI chr 8:128,169,191...128,266,681
Ensembl chr 8:128,169,191...128,266,639
JBrowse link
G Skor1 SKI family transcriptional corepressor 1 affects binding ISO Fluorescein-5-isothiocyanate binds to SKOR1 protein CTD PMID:27129696 NCBI chr 8:68,029,930...68,040,504
Ensembl chr 8:68,030,621...68,038,533
JBrowse link
G Slc38a10 solute carrier family 38, member 10 affects binding ISO Fluorescein-5-isothiocyanate binds to SLC38A10 protein CTD PMID:27129696 NCBI chr10:109,284,054...109,333,907
Ensembl chr10:109,284,957...109,333,899
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT3 protein]] CTD PMID:27871981 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
increases phosphorylation
ISO diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT5 protein]] CTD PMID:27871981 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases phosphorylation
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased phosphorylation of STAT6 protein]]
CTD PMID:27871981 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 affects binding ISO Fluorescein-5-isothiocyanate binds to TRPA1 protein CTD PMID:27129696 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions
ISO Fluorescein-5-isothiocyanate results in increased expression of TSLP protein
diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]; Melatonin inhibits the reaction [diisodecyl phthalate promotes the reaction [Fluorescein-5-isothiocyanate results in increased expression of TSLP protein]]
CTD PMID:27871981 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO Fluorescein-5-isothiocyanate results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Usp3 ubiquitin specific peptidase 3 affects binding ISO Fluorescein-5-isothiocyanate binds to USP3 protein CTD PMID:27129696 NCBI chr 8:72,207,970...72,284,871
Ensembl chr 8:72,207,972...72,284,873
JBrowse link
N-\{6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoyl\}sphingosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine CTD PMID:21436125 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal affects expression
multiple interactions
ISO pyrene affects the expression of ACP2 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of ACP2 protein
CTD PMID:28803881 NCBI chr 3:80,020,346...80,030,365
Ensembl chr 3:80,021,440...80,030,363
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects binding
affects response to substance
increases activity
EXP
ISO
pyrene binds to and results in increased activity of AHR protein; pyrene inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
pyrene binds to AHR protein
[AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA; [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A6A mRNA; AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]
pyrene results in increased activity of AHR protein
[benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene co-treated with pyrene] results in increased activity of AHR protein; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [indeno(1,2,3-cd)pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene] promotes the reaction [pyrene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with pyrene] promotes the reaction [fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [chrysene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(k)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benzo(j)fluoranthene results in increased activity of AHR protein]; [benz(a)anthracene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [Benzo(a)pyrene co-treated with benzo(j)fluoranthene co-treated with benzo(k)fluoranthene co-treated with chrysene co-treated with indeno(1,2,3-cd)pyrene co-treated with fluoranthene co-treated with pyrene] promotes the reaction [benz(a)anthracene results in increased activity of AHR protein]; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein; [pyrene co-treated with Benzo(a)pyrene] results in increased activity of AHR protein; [pyrene co-treated with naphthalene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; [pyrene co-treated with phenanthrene] inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; fluoranthene promotes the reaction [pyrene results in increased activity of AHR protein]; pyrene promotes the reaction [fluoranthene results in increased activity of AHR protein]
CTD PMID:3024361, PMID:12850102, PMID:17618724, PMID:17665671, PMID:28710019, PMID:29502740, PMID:30980910 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHRR protein; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AHR protein]; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein] CTD PMID:28710019, PMID:30980910 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329
JBrowse link
G Ar androgen receptor multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of AR protein]; pyrene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; pyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785, PMID:26022396, PMID:30980910 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of ARNT protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of ARNT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ARNT mRNA CTD PMID:28710019 NCBI chr 2:196,594,178...196,651,486
Ensembl chr 2:196,594,303...196,651,179
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of BAX protein
pyrene affects the expression of BAX protein
CTD PMID:28803881 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
EXP
ISO
pyrene results in increased expression of CASP3 mRNA
pyrene results in increased activity of CASP3 protein
pyrene results in increased expression of CASP3 protein
[naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CASP3 protein
CTD PMID:19815060, PMID:28803881, PMID:31368503 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity EXP pyrene results in increased activity of CASP7 protein CTD PMID:31368503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in decreased expression of CCNA2 protein
pyrene results in decreased expression of CCNA2 protein
CTD PMID:28803881 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CCND1 protein
pyrene results in increased expression of CCND1 protein
CTD PMID:28803881 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd63 Cd63 molecule decreases expression EXP pyrene results in decreased expression of CD63 protein CTD PMID:31368503 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Cd81 Cd81 molecule decreases expression EXP pyrene results in decreased expression of CD81 protein CTD PMID:31368503 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
increases expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] results in increased expression of CDK2 protein
pyrene results in increased expression of CDK2 protein
CTD PMID:28803881 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of COMT mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of and affects the activity of COMT protein CTD PMID:28710019 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects expression
ISO [naphthalene co-treated with anthracene co-treated with phenanthrene co-treated with pyrene] affects the expression of CYP19A1 protein
pyrene affects the expression of CYP19A1 protein
CTD PMID:28803881 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases activity
increases hydroxylation
ISO
EXP
[Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 mRNA; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] affects the expression of CYP1A1 protein; [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein; [phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; AHRR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in decreased expression of CYP1A1 protein]
pyrene results in increased expression of CYP1A1 mRNA
pyrene results in increased expression of CYP1A1 mRNA; pyrene results in increased expression of CYP1A1 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA
pyrene results in increased activity of CYP1A1 protein
CYP1A1 protein results in increased hydroxylation of pyrene
CTD PMID:7750161, PMID:15016593, PMID:15566942, PMID:16906435, PMID:25956473, PMID:26160115, PMID:28710019, PMID:30240548, PMID:30980910 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases hydroxylation
increases expression
multiple interactions
ISO
EXP
CYP1A2 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1A2 mRNA
pyrene results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of CYP1A2 protein
[fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A2 mRNA; pyrene results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:7750161, PMID:15016593, PMID:17618724, PMID:26160115, PMID:30240548 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases hydroxylation
increases expression
multiple interactions
ISO CYP1B1 protein results in increased hydroxylation of pyrene
pyrene results in increased expression of CYP1B1 protein
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; pyrene binds to and results in decreased activity of CYP1B1 protein; pyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
CTD PMID:15016593, PMID:15566942, PMID:19365803, PMID:19563207, PMID:30248327 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO
EXP
NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]
pyrene results in increased expression of CYP2B1 mRNA
CTD PMID:17618724, PMID:26160115, PMID:30240548 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pyrene results in increased expression of CYP2B2 mRNA CTD PMID:30240548 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO pyrene results in increased expression of CYP2B6 mRNA
[pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD PMID:26160115 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects expression EXP pyrene affects the expression of CYP2C11 mRNA CTD PMID:30240548 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects expression EXP pyrene affects the expression of CYP2C6V1 mRNA CTD PMID:30240548 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP pyrene results in decreased expression of CYP2E1 mRNA CTD PMID:30240548 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP pyrene results in increased expression of CYP3A23-3A1 mRNA CTD PMID:30240548 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein; AHR protein affects the reaction [[naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of ESR1 protein] CTD PMID:30980910 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP pyrene results in decreased expression of GJB1 protein CTD PMID:25268939 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression
ISO [Docosahexaenoic Acids co-treated with pyrene] results in decreased expression of GSTM1 protein
pyrene results in increased expression of GSTM1 mRNA
CTD PMID:25956473, PMID:26160115 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO pyrene results in increased expression of GSTM3 mRNA CTD PMID:26160115 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO pyrene results in increased expression of HSPA1A mRNA CTD PMID:22367790 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO pyrene results in increased expression of ICAM1 protein CTD PMID:22313677 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma affects activity ISO pyrene affects the activity of IFNG protein CTD PMID:9258441 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il4 interleukin 4 increases expression ISO pyrene results in increased expression of IL4 mRNA; pyrene results in increased expression of IL4 protein CTD PMID:10756232 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [naphthalene co-treated with phenanthrene co-treated with anthracene co-treated with fluoranthene co-treated with pyrene] results in increased expression of NFKB2 protein CTD PMID:30980910 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP pyrene results in increased activity of NQO1 protein CTD PMID:16906435 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
decreases expression
increases activity
increases response to substance
increases expression
ISO
EXP
AHR gene mutant form promotes the reaction [pyrene results in increased expression of NR1I3 mRNA]; NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione]; NR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]; pyrene affects the localization of and results in increased activity of NR1I3 protein
pyrene results in decreased expression of NR1I3 mRNA
pyrene results in increased activity of NR1I3 protein
NR1I3 results in increased susceptibility to pyrene
[pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA
CTD PMID:17618724, PMID:26160115, PMID:28927721, PMID:30240548 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO pyrene results in increased cleavage of PARP1 protein CTD PMID:21132278 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein increases expression EXP pyrene results in increased expression of PDCD6IP protein CTD PMID:31368503 NCBI chr 8:121,916,233...121,973,145
Ensembl chr 8:121,916,185...121,973,125
JBrowse link
G Pgr progesterone receptor multiple interactions ISO pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A increases mutagenesis EXP pyrene results in increased mutagenesis of PIGA CTD PMID:22923490 NCBI chr  X:31,786,823...31,799,751
Ensembl chr  X:31,786,194...31,799,560
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Docosahexaenoic Acids co-treated with pyrene] results in increased expression of PTGS2 mRNA CTD PMID:25956473 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases expression
ISO pyrene results in increased expression of and results in increased activity of SULT1A1 protein
pyrene results in increased expression of SULT1A1 mRNA
CTD PMID:17618724, PMID:26160115 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene CTD PMID:23458896 NCBI chr16:50,016,466...50,031,011
Ensembl chr16:50,016,857...50,031,214
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [pyrene results in increased expression of CXCL8 mRNA] CTD PMID:18434080 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO pyrene promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 protein] CTD PMID:22120587 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsg101 tumor susceptibility 101 increases expression EXP pyrene results in increased expression of TSG101 protein CTD PMID:31368503 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO [AHR affects the susceptibility to pyrene] which affects the expression of UGT1A1 mRNA CTD PMID:17618724 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression
multiple interactions
ISO pyrene results in decreased expression of UGT1A6 mRNA
[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of UGT1A6 mRNA
CTD PMID:15566942, PMID:26160115 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
scopoletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACAA1A mRNA] CTD PMID:26115886 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased phosphorylation of ACACA protein] CTD PMID:26115886 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA] CTD PMID:26115886 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ACSL1 mRNA] CTD PMID:26115886 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOQ protein] CTD PMID:26115886 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
increases expression
EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 mRNA]; Scopoletin inhibits the reaction [Ethanol results in decreased expression of ADIPOR2 protein]
scopoletin increases expression of adipor2 mRNA and protein in epididymal white adipose tissue of alcohol fed rats
CTD PMID:26115886, PMID:26115886 RGD:25330099 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions EXP Scopoletin inhibits the reaction [Alcohols affects the expression of CIDEA mRNA] CTD PMID:26115886 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of FASN mRNA] CTD PMID:26115886 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased activity of GPT protein] CTD PMID:26115886 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26115886 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:26115886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein] CTD PMID:26115886 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of MYD88 mRNA] CTD PMID:26115886 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of PNPLA2 mRNA] CTD PMID:26115886 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA] CTD PMID:26115886 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA] CTD PMID:26115886 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TICAM1 mRNA] CTD PMID:26115886 NCBI chr 9:10,780,185...10,790,280 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TLR4 mRNA] CTD PMID:26115886 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:26115886 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Scopoletin CTD PMID:15802387 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Scopoletin CTD PMID:15044611, PMID:15802387 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Scopoletin CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor affects response to substance ISO XPC protein affects the susceptibility to Scopoletin CTD PMID:22280988 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
scopolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ide insulin degrading enzyme multiple interactions ISO scopolin binds to and affects the activity of IDE protein CTD PMID:23146021 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495
JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO scopolin binds to and affects the activity of UROD protein CTD PMID:23209648 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
umbelliferone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein] CTD PMID:24661945 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases expression
ISO 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; 7-hydroxycoumarin inhibits the reaction [AKR1C3 mutant form results in increased susceptibility to Hydrogen Peroxide]
7-hydroxycoumarin results in increased expression of AKR1C3 mRNA; 7-hydroxycoumarin results in increased expression of AKR1C3 protein
CTD PMID:22964423, PMID:28263721 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 multiple interactions
increases expression
ISO 7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]
7-hydroxycoumarin results in increased expression of AKR7A2 mRNA; 7-hydroxycoumarin results in increased expression of AKR7A2 protein
CTD PMID:22964423, PMID:28263721, PMID:30849339 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression ISO 7-hydroxycoumarin results in increased expression of AKR7A3 mRNA CTD PMID:28263721 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 7-hydroxycoumarin results in increased expression of BAX protein CTD PMID:15964220 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 7-hydroxycoumarin results in decreased expression of BCL2 protein CTD PMID:15964220 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cat catalase multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein] CTD PMID:24661945 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 7-hydroxycoumarin results in decreased expression of CCND1 protein CTD PMID:11679177 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO 7-hydroxycoumarin inhibits the reaction [Dietary Fats results in increased activity of CYP2E1 protein] CTD PMID:24661945 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP 7-hydroxycoumarin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] CTD PMID:26995004 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation
ISO [4-aminobenzhydrazide results in decreased activity of MPO protein] which affects the susceptibility to 7-hydroxycoumarin
MPO protein results in increased oxidation of 7-hydroxycoumarin
CTD PMID:23994743 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
ISO 7-hydroxycoumarin results in increased expression of and affects the localization of NFE2L2 protein
7-hydroxycoumarin results in increased expression of NFE2L2 mRNA
CTD PMID:28263721 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO
EXP
SULT1A1 protein results in increased sulfation of 7-hydroxycoumarin CTD PMID:11181495 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
EXP UGT1A6 gene polymorphism affects the metabolism of 7-hydroxycoumarin
UGT1A6 protein results in increased metabolism of 7-hydroxycoumarin
CTD PMID:9429234 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases glucuronidation EXP UGT1A7 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:95,233,957...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation EXP UGT1A8 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15502008 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 7-hydroxycoumarin CTD PMID:15044611 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of 7-hydroxycoumarin CTD PMID:7574722 NCBI chr14:22,553,633...22,591,461
Ensembl chr14:22,553,650...22,591,461
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        probe 484
          6beta-hydroxycortisol 0
          6beta-hydroxycortisone 0
          [(ppy)2Ir(mbpy-monoacid)]Cl 0
          carbon monoxide 95
          erythromycin-[N-methyl-(14)C] 0
          fluorescent probe + 417
          peptide probe + 0
          spin probe 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.