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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ergostanoid
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Accession:CHEBI:50403 term browser browse the term
Synonyms:related_synonym: ergostanoids


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ergosta-4,6,8(14),22-tetraen-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of ACTA2 protein] CTD PMID:28578904 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Agt angiotensinogen multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of VIM protein]
ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of SYNPO protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:28578904 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of CCL2 protein] CTD PMID:28578904 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of CDH1 protein] CTD PMID:28578904 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of COL3A1 protein] CTD PMID:28578904 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein] CTD PMID:28578904 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein] CTD PMID:28578904 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein] CTD PMID:28578904 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Podxl podocalyxin-like multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of PTGS2 protein] CTD PMID:28578904 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of SNAI1 protein] CTD PMID:28578904 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Synpo synaptopodin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of SYNPO protein] CTD PMID:28578904 NCBI chr18:55,863,081...55,921,412
Ensembl chr18:55,865,467...55,916,220
JBrowse link
G Vim vimentin multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of VIM protein] CTD PMID:28578904 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:95,133,221...95,180,574
Ensembl chr 3:95,133,713...95,180,564
JBrowse link
ergosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CASP1 protein] CTD PMID:25833014 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of CCL2 protein] CTD PMID:25833014 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cyp51 cytochrome P450, family 51 multiple interactions ISO CYP51A1 gene inhibits the reaction [Fluconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Ketoconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Voriconazole results in decreased chemical synthesis of Ergosterol] CTD PMID:18694951 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of ICAM1 protein] CTD PMID:25833014 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein; [Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of IL1B protein]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of IL1B mRNA] CTD PMID:25833014 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of MAPK14 mRNA] CTD PMID:25833014 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of NLRP3 protein] CTD PMID:25833014 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of OLR1 protein] CTD PMID:25833014 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of PYCARD protein] CTD PMID:25833014 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA; [Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA mRNA]; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of RELA protein] CTD PMID:25833014 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in decreased expression of SIRT1 mRNA] CTD PMID:25833014 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Vwf von Willebrand factor multiple interactions EXP [Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein; resveratrol inhibits the reaction [[Cholesterol co-treated with Ergosterol] results in increased expression of and results in increased secretion of VWF protein] CTD PMID:25833014 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
ergosterol peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO ergosterol-5,8-peroxide results in increased activity of CASP3 protein CTD PMID:20100469 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
withaferin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO withaferin A inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]] CTD PMID:20438634 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of ADAM17 protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein] CTD PMID:21266191 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO withaferin A results in decreased expression of and results in decreased phosphorylation of BAD protein CTD PMID:20438634 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO withaferin A results in decreased expression of BCL2 protein CTD PMID:20438634, PMID:21256832, PMID:21964475 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA] CTD PMID:20438634 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bcl2l11 BCL2 like 11 decreases expression ISO withaferin A results in decreased expression of BCL2L11 protein CTD PMID:20438634 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA] CTD PMID:20438634 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA] CTD PMID:20438634 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects binding
multiple interactions
increases expression
ISO withaferin A binds to CDKN1A protein
withaferin A results in increased expression of and affects the localization of CDKN1A protein
withaferin A results in increased expression of CDKN1A mRNA
CTD PMID:22973447 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2aip CDKN2A interacting protein decreases expression ISO withaferin A results in decreased expression of CDKN2AIP protein CTD PMID:22973447 NCBI chr16:47,664,864...47,670,935
Ensembl chr16:47,665,816...47,669,093
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 affects response to substance
multiple interactions
increases expression
ISO DDIT3 mRNA affects the susceptibility to withaferin A
Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT3 protein]
CTD PMID:21266191 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [withaferin A results in increased expression of DDIT4 protein] CTD PMID:21266191 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression ISO withaferin A results in decreased expression of DNMT1 mRNA; withaferin A results in decreased expression of DNMT1 protein CTD PMID:23593078 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO withaferin A results in decreased expression of DNMT3A mRNA CTD PMID:23593078 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO withaferin A results in decreased expression of DNMT3B mRNA CTD PMID:23593078 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO withaferin A results in increased phosphorylation of EIF2A protein CTD PMID:21266191 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Ezr ezrin multiple interactions ISO [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of EZR protein CTD PMID:25236891 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO withaferin A results in decreased expression of HDAC1 protein CTD PMID:23593078 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of HNRNPK protein; withaferin A binds to and results in decreased activity of HNRNPK protein CTD PMID:25236891 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 affects binding
multiple interactions
ISO withaferin A binds to HSPA9 protein
[6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of HSPA9 protein; [withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD PMID:22973447, PMID:25236891 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL6 protein] CTD PMID:20438634 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of MAPK1 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:24019090, PMID:24632454, PMID:25236891 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of MAPK3 protein; Acetylcysteine inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090, PMID:24632454, PMID:25236891 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO withaferin A results in increased phosphorylation of MAPK8 protein CTD PMID:21964475 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression
ISO MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein]
withaferin A results in increased expression of MCL1 protein
CTD PMID:24019090 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mecp2 methyl CpG binding protein 2 decreases expression ISO withaferin A results in decreased expression of MECP2 protein CTD PMID:23593078 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased expression of MMP2 protein CTD PMID:25236891 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects binding ISO withaferin A binds to NFE2L2 protein CTD PMID:22973447 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:20438634 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]; MCL1 mutant form promotes the reaction [withaferin A results in increased cleavage of PARP1 protein] CTD PMID:20438634, PMID:24019090 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Procr protein C receptor multiple interactions ISO withaferin A inhibits the reaction [IL1B protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]] CTD PMID:24632454 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO withaferin A inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprostone]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:21396905 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein] CTD PMID:20438634 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK1 protein]; SOD2 protein inhibits the reaction [withaferin A results in increased phosphorylation of MAPK3 protein] CTD PMID:24019090 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of and results in increased activity of STAT1 protein] CTD PMID:21396905 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:21396905 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity
ISO withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]
withaferin A results in decreased activity of TNF protein
CTD PMID:20438634, PMID:24632454 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA] CTD PMID:20438634 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tp53 tumor protein p53 increases expression
affects binding
multiple interactions
ISO withaferin A results in increased expression of TP53 mRNA
withaferin A binds to TP53 protein
[withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]] which affects the localization of and results in increased activity of TP53 protein; withaferin A inhibits the reaction [HSPA9 protein binds to TP53 protein]
CTD PMID:22973447 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO withaferin A results in decreased expression of TUBA1A mRNA CTD PMID:24297176 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression ISO withaferin A results in decreased expression of TUBB mRNA CTD PMID:24297176 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO [6,7-epoxy-5,17-dihydroxy-1-oxowitha-2,24-dienolide co-treated with withaferin A] results in decreased secretion of VEGFA protein; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]
withaferin A results in decreased expression of VEGFA protein
CTD PMID:20438634, PMID:25236891 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
increases splicing
ISO withaferin A results in increased expression of XBP1 protein
withaferin A results in increased splicing of XBP1 mRNA
CTD PMID:21266191 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          carbon atom 19588
            organic molecular entity 19588
              lipid 17055
                steroid 12793
                  ergostanoid 67
                    (20S)-5-ergostene-3beta,7alpha,16beta,20-tetrol 0
                    (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                    (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                    (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                    (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                    (22E,24R)-ergosta-7,22-diene-3beta,6beta-diol 0
                    (22E,24R)-ergosta-7,22-diene-6beta-methoxy-3beta,5alpha-diol 0
                    (22E,24S)-5alpha,8alpha-epidioxy-24-methylcholesta-6,22-dien-3beta-ol 0
                    (22E,24S)-5alpha,8alpha-epidioxy-24-methylcholesta-6,9,22-trien-3beta -ol 0
                    (22S,24R)-3alpha-ureido-ergosta-4,6,8(14),22-tetraene 0
                    (3beta,5alpha)-ergosta-8,22-dien-3-ol 0
                    17alpha-hydroxywithanolide D 0
                    2,3-dihydro-3beta-O-sulfate withaferin A 0
                    2,3-dihydro-3beta-methoxy withaferin A 0
                    2,3-dihydrowithaferin A 0
                    20-hydroxytubocapsanolide A 0
                    23-hydroxytubocapsanolide A 0
                    24-epicampesterol 0
                    24-methylenecholesta-1,4-dien-3-one 0
                    3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                    3beta,11alpha-dihydroxyergosta-8,24(28)-dien-7-one 0
                    3beta-hydroxyergosta-8,24(28)-dien-7-one 0
                    4alpha-Methylfecosterol 0
                    5,7,24(28)-Ergostatrienol 0
                    9alpha,11alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one 0
                    Camphoratin H 0
                    Camphoratin I 0
                    Camphoratin J 0
                    Ergosterol D 0
                    Halistanol sulfate 0
                    Hatomasterol 0
                    Lichesterol 0
                    Stylisterol A 0
                    Stylisterol B 0
                    Stylisterol C 0
                    antcin A 0
                    blazein 0
                    brassicasterol + 0
                    cerevisterol 0
                    crinosterol 0
                    dehydroergosterol 0
                    episterol + 0
                    ergosta-4,6,8(14),22-tetraen-3-one 15
                    ergosta-5,7-dien-3beta-ol 0
                    ergostane ester + 0
                    ergostane sterol 0
                    ergosterol + 13
                    ergosterol peroxide 1
                    fungisterol 0
                    ganodesterone 0
                    methyl 4alpha-methylergost-8,24(28)-diene-3,11-dion-26-oate 0
                    minabeolide 1 0
                    minabeolide 2 0
                    paraminabeolide A 0
                    paraminabeolide B 0
                    paraminabeolide C 0
                    paraminabeolide D 0
                    paraminabeolide E 0
                    paraminabeolide F 0
                    sinularia glycoside 0
                    sitoindoside IX 0
                    tubocapsanolide A + 0
                    tubocapsanolide F 0
                    viscosalactone B 0
                    withaferin A + 45
                    withalongolide A 0
                    withalongolide B 0
                    withalongolide C 0
                    withalongolide D 0
                    withalongolide E 0
                    withalongolide G 0
                    withalongolide H 0
                    withalongolide I 0
                    withalongolide J 0
                    withanolide D + 0
                    zhankuic acid A + 0
                    zhankuic acid A methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic polycyclic compound 16393
                                  steroid 12793
                                    steroid fundamental parent 12407
                                      ergostane 67
                                        ergostanoid 67
                                          (20S)-5-ergostene-3beta,7alpha,16beta,20-tetrol 0
                                          (22E,24R)-3beta,5alpha,9alpha-trihydroxyergosta-7,22-dien-6-one 0
                                          (22E,24R)-3beta,5alpha-dihydroxyergosta-7,22-dien-6-one 0
                                          (22E,24R)-ergosta-5alpha,6alpha-epoxide-8,22-diene-3beta,7alpha-diol 0
                                          (22E,24R)-ergosta-7,22-diene-3,6-dione 0
                                          (22E,24R)-ergosta-7,22-diene-3beta,6beta-diol 0
                                          (22E,24R)-ergosta-7,22-diene-6beta-methoxy-3beta,5alpha-diol 0
                                          (22E,24S)-5alpha,8alpha-epidioxy-24-methylcholesta-6,22-dien-3beta-ol 0
                                          (22E,24S)-5alpha,8alpha-epidioxy-24-methylcholesta-6,9,22-trien-3beta -ol 0
                                          (22S,24R)-3alpha-ureido-ergosta-4,6,8(14),22-tetraene 0
                                          (3beta,5alpha)-ergosta-8,22-dien-3-ol 0
                                          17alpha-hydroxywithanolide D 0
                                          2,3-dihydro-3beta-O-sulfate withaferin A 0
                                          2,3-dihydro-3beta-methoxy withaferin A 0
                                          2,3-dihydrowithaferin A 0
                                          20-hydroxytubocapsanolide A 0
                                          23-hydroxytubocapsanolide A 0
                                          24-epicampesterol 0
                                          24-methylenecholesta-1,4-dien-3-one 0
                                          3alpha,6alpha-epoxy-4beta,5beta,27-trihydroxy-1-oxowitha-24-enolide 0
                                          3beta,11alpha-dihydroxyergosta-8,24(28)-dien-7-one 0
                                          3beta-hydroxyergosta-8,24(28)-dien-7-one 0
                                          4alpha-Methylfecosterol 0
                                          5,7,24(28)-Ergostatrienol 0
                                          9alpha,11alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one 0
                                          Camphoratin H 0
                                          Camphoratin I 0
                                          Camphoratin J 0
                                          Ergosterol D 0
                                          Halistanol sulfate 0
                                          Hatomasterol 0
                                          Lichesterol 0
                                          Stylisterol A 0
                                          Stylisterol B 0
                                          Stylisterol C 0
                                          antcin A 0
                                          blazein 0
                                          brassicasterol + 0
                                          cerevisterol 0
                                          crinosterol 0
                                          dehydroergosterol 0
                                          episterol + 0
                                          ergosta-4,6,8(14),22-tetraen-3-one 15
                                          ergosta-5,7-dien-3beta-ol 0
                                          ergostane ester + 0
                                          ergostane sterol 0
                                          ergosterol + 13
                                          ergosterol peroxide 1
                                          fungisterol 0
                                          ganodesterone 0
                                          methyl 4alpha-methylergost-8,24(28)-diene-3,11-dion-26-oate 0
                                          minabeolide 1 0
                                          minabeolide 2 0
                                          paraminabeolide A 0
                                          paraminabeolide B 0
                                          paraminabeolide C 0
                                          paraminabeolide D 0
                                          paraminabeolide E 0
                                          paraminabeolide F 0
                                          sinularia glycoside 0
                                          sitoindoside IX 0
                                          tubocapsanolide A + 0
                                          tubocapsanolide F 0
                                          viscosalactone B 0
                                          withaferin A + 45
                                          withalongolide A 0
                                          withalongolide B 0
                                          withalongolide C 0
                                          withalongolide D 0
                                          withalongolide E 0
                                          withalongolide G 0
                                          withalongolide H 0
                                          withalongolide I 0
                                          withalongolide J 0
                                          withanolide D + 0
                                          zhankuic acid A + 0
                                          zhankuic acid A methyl ester 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.