Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3',4',7-trihydroxyisoflavone
go back to main search page
Accession:CHEBI:50399 term browser browse the term
Definition:A 7-hydroxyisoflavone that is daidzein substituted by a hydroxy group at position 3'.
Synonyms:exact_synonym: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one
 related_synonym: 3'-hydroxydaidzein;   3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-2-3-10-14(6-9)20-7-11(15(10)19)8-1-4-12(17)13(18)5-8/h1-7,16-18H;   InChIKey=DDKGKOOLFLYZDL-UHFFFAOYSA-N;   SMILES=OC1=CC=C2C(OC=C(C2=O)C2=CC=C(O)C(O)=C2)=C1
 alt_id: CHEBI:33177;   CHEBI:34315
 xref: Beilstein:251800;   CAS:485-63-2;   HMDB:HMDB0041655;   KEGG:C14313;   KNApSAcK:C00009384;   LIPID_MAPS_instance:LMPK12050055
 xref_mesh: MESH:C061213
 xref: PDBeChem:47X;   PMID:19577190;   PMID:20185308;   PMID:21378167;   PMID:22497114;   PMID:23265084;   PMID:26322379;   Reaxys:251800



show annotations for term's descendants           Sort by:
 
3',4',7-trihydroxyisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO 3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA
3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]
CTD PMID:22914566 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases expression
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA] CTD PMID:22914566 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression
ISO 3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA] CTD PMID:22914566 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA
3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of BAX mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of BAX mRNA]
CTD PMID:22914566 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP3 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP3 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP3 mRNA] CTD PMID:22914566 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of CASP9 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased activity of CASP9 protein]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of CASP9 mRNA] CTD PMID:22914566 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA] CTD PMID:22914566 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO 3',4',7-trihydroxyisoflavone promotes the reaction [Epirubicin results in increased expression of TP53 mRNA]; Epirubicin promotes the reaction [3',4',7-trihydroxyisoflavone results in increased expression of TP53 mRNA] CTD PMID:22914566 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          metabolite 19623
            3',4',7-trihydroxyisoflavone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      ketone 17091
                                        cyclic ketone 15644
                                          isoflavones 3757
                                            hydroxyisoflavone 3690
                                              7-hydroxyisoflavones 3668
                                                daidzein 251
                                                  3',4',7-trihydroxyisoflavone 8
paths to the root