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ONTOLOGY REPORT - ANNOTATIONS


Term:nitisinone
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Accession:CHEBI:50378 term browser browse the term
Definition:A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.
Synonyms:exact_synonym: 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
 related_synonym: 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione;   Formula=C14H10F3NO5;   InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2;   InChIKey=OUBCNLGXQFSTLU-UHFFFAOYSA-N;   Orfadin;   SMILES=[O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F;   nitisinona;   nitisinonum
 xref: CAS:104206-65-7 "ChemIDplus";   DrugBank:DB00348;   Drug_Central:1944 "DrugCentral";   HMDB:HMDB0014492;   KEGG:D05177
 xref_mesh: MESH:C077073
 xref: PMID:14668946 "Europe PMC";   PMID:15297036 "Europe PMC";   PMID:17152330 "Europe PMC";   PMID:17458044 "Europe PMC";   PMID:20883679 "Europe PMC";   PMID:21377430 "Europe PMC";   PMID:21620748 "Europe PMC";   PMID:21752152 "Europe PMC";   PMID:21813063 "Europe PMC";   PMID:21968107 "Europe PMC";   PMID:21968110 "Europe PMC";   PMID:22456946 "Europe PMC";   PMID:22885033 "Europe PMC";   PMID:23146787 "Europe PMC";   PMID:23203167 "Europe PMC";   PMID:23250512 "Europe PMC";   PMID:23311542 "Europe PMC";   PMID:23430914 "Europe PMC";   PMID:23430917 "Europe PMC";   PMID:23486607 "Europe PMC";   PMID:23511227 "Europe PMC";   Patent:EP186118;   Patent:US4774360;   Patent:US5006158;   Patent:US5550165;   Patent:US5668089;   Reaxys:8639943 "Reaxys";   Wikipedia:Nitisinone


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nitisinone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 6 53,497,341 53,545,101 RGD:6480464
G GCLM glutamate-cysteine ligase modifier subunit JBrowse link 1 93,885,199 93,910,370 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G HPD 4-hydroxyphenylpyruvate dioxygenase JBrowse link 12 121,839,527 121,888,611 RGD:6480464
G NQO1 NAD(P)H quinone dehydrogenase 1 JBrowse link 16 69,709,401 69,726,560 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23754
    role 23643
      biological role 23606
        xenobiotic 19300
          mesotrione 5
            nitisinone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 23754
    subatomic particle 23703
      composite particle 23703
        hadron 23703
          baryon 23703
            nucleon 23703
              atomic nucleus 23703
                atom 23703
                  main group element atom 23522
                    p-block element atom 23522
                      carbon group element atom 23232
                        carbon atom 23208
                          organic molecular entity 23208
                            organic group 21894
                              organic divalent group 21866
                                organodiyl group 21866
                                  carbonyl group 21838
                                    carbonyl compound 21838
                                      ketone 18001
                                        aromatic ketone 13241
                                          benzophenones 1122
                                            benzophenone 676
                                              mesotrione 5
                                                nitisinone 5
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