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ONTOLOGY REPORT - ANNOTATIONS


Term:nitisinone
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Accession:CHEBI:50378 term browser browse the term
Definition:A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.
Synonyms:exact_synonym: 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
 related_synonym: 2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione;   Formula=C14H10F3NO5;   InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2;   InChIKey=OUBCNLGXQFSTLU-UHFFFAOYSA-N;   Orfadin;   SMILES=[O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F;   nitisinona;   nitisinonum
 xref: CAS:104206-65-7 "ChemIDplus";   DrugBank:DB00348;   Drug_Central:1944 "DrugCentral";   HMDB:HMDB0014492;   KEGG:D05177
 xref_mesh: MESH:C077073
 xref: PMID:14668946 "Europe PMC";   PMID:15297036 "Europe PMC";   PMID:17152330 "Europe PMC";   PMID:17458044 "Europe PMC";   PMID:20883679 "Europe PMC";   PMID:21377430 "Europe PMC";   PMID:21620748 "Europe PMC";   PMID:21752152 "Europe PMC";   PMID:21813063 "Europe PMC";   PMID:21968107 "Europe PMC";   PMID:21968110 "Europe PMC";   PMID:22456946 "Europe PMC";   PMID:22885033 "Europe PMC";   PMID:23146787 "Europe PMC";   PMID:23203167 "Europe PMC";   PMID:23250512 "Europe PMC";   PMID:23311542 "Europe PMC";   PMID:23430914 "Europe PMC";   PMID:23430917 "Europe PMC";   PMID:23486607 "Europe PMC";   PMID:23511227 "Europe PMC";   Patent:EP186118;   Patent:US4774360;   Patent:US5006158;   Patent:US5550165;   Patent:US5668089;   Reaxys:8639943 "Reaxys";   Wikipedia:Nitisinone


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nitisinone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hpd 4-hydroxyphenylpyruvate dioxygenase JBrowse link 12 38,828,606 38,839,956 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    role 19680
      biological role 19678
        xenobiotic 18334
          mesotrione 5
            nitisinone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      ketone 15917
                                        aromatic ketone 11831
                                          benzophenones 1124
                                            benzophenone 680
                                              mesotrione 5
                                                nitisinone 5
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