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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:milbemycin
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Accession:CHEBI:50345 term browser browse the term
Synonyms:related_synonym: milbemycins
 xref_mesh: MESH:C027837
 xref: Wikipedia:Milbemycin


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milbemycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
decreases expression
ISO moxidectin results in decreased activity of ABCB1A protein
moxidectin results in decreased expression of ABCB1 protein
CTD PMID:17134887, PMID:21458446 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases export
multiple interactions
ISO ABCG2 protein results in increased export of moxidectin
tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of moxidectin]
CTD PMID:19428349 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; moxidectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666, PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            prokaryotic metabolite 18357
              bacterial metabolite 18357
                milbemycin 4
                  5-Oxoavermectin "2a" aglycone 0
                  5-Oxoavermectin "2b" aglycone 0
                  6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone 0
                  LL-F28249 beta 0
                  LSM-1593 0
                  LSM-1662 0
                  LSM-5397 0
                  VM 44857 0
                  VM 44864 0
                  VM 44865 0
                  VM 44866 0
                  milbemycin A3 + 0
                  milbemycin A4 + 0
                  milbemycin D 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic ester 14077
                                        lactone 5979
                                          macrocyclic lactone 1731
                                            macrolide 1598
                                              avermectin analogue 4
                                                milbemycin 4
                                                  5-Oxoavermectin "2a" aglycone 0
                                                  5-Oxoavermectin "2b" aglycone 0
                                                  6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone 0
                                                  LL-F28249 beta 0
                                                  LSM-1593 0
                                                  LSM-1662 0
                                                  LSM-5397 0
                                                  VM 44857 0
                                                  VM 44864 0
                                                  VM 44865 0
                                                  VM 44866 0
                                                  milbemycin A3 + 0
                                                  milbemycin A4 + 0
                                                  milbemycin D 0
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