CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: milbemycin
Accession: CHEBI:50345
browse the term
Synonyms: related_synonym: milbemycins
xref_mesh: MESH:C027837
xref: Wikipedia:Milbemycin
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity decreases expression
ISO
moxidectin results in decreased activity of ABCB1A protein moxidectin results in decreased expression of ABCB1 protein
CTD
PMID:17134887 PMID:21458446
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcg2
ATP binding cassette subfamily G member 2
increases export multiple interactions
ISO
ABCG2 protein results in increased export of moxidectin tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of moxidectin]
CTD
PMID:19428349
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Ano1
anoctamin 1
decreases activity
ISO
moxidectin results in decreased activity of ANO1 protein
CTD
PMID:32201246
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
CTD
PMID:27773686
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; moxidectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666 PMID:27773686
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression
ISO
nemadectin results in decreased expression of ABCB1 mRNA; nemadectin results in decreased expression of ABCB1 protein
CTD
PMID:20487225
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity multiple interactions
ISO
selamectin results in decreased activity of ABCB1A protein [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to selamectin
CTD
PMID:17134887 PMID:19161460
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb1b
ATP-binding cassette, sub-family B member 1B
multiple interactions
ISO
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to selamectin
CTD
PMID:19161460
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
G
Ano1
anoctamin 1
decreases activity
ISO
selamectin results in decreased activity of ANO1 protein
CTD
PMID:32201246
NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
G
Cdh1
cadherin 1
increases expression
ISO
selamectin results in increased expression of CDH1
CTD
PMID:26078298
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
G
Esr1
estrogen receptor 1
increases expression
ISO
selamectin results in increased expression of ESR1
CTD
PMID:26078298
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Mxd1
max dimerization protein 1
multiple interactions
ISO
selamectin inhibits the reaction [MXD1 protein binds to SIN3A protein]
CTD
PMID:26078298
NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
CTD
PMID:27773686
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; selamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; selamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
CTD
PMID:25257666 PMID:27773686
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
G
Sin3a
SIN3 transcription regulator family member A
multiple interactions
ISO
selamectin inhibits the reaction [MXD1 protein binds to SIN3A protein]
CTD
PMID:26078298
NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19918
role
19894
biological role
19892
biochemical role
19588
metabolite
19574
prokaryotic metabolite
18616
bacterial metabolite
18616
milbemycin
10
(1R,4S,4'S,5'S,6R,6'S,8R,10E,13R,14E,16Z,20R,21R,24S)-4',21,24-trihydroxy-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2,18-dione
0
(1S,4R,4'S,5'S,6'S,7R,8R,9S,10E,12E,14R,16E,19R,21R)-4',8,9-trihydroxy-10-(hydroxymethyl)-7-methoxy-5',6,14,16-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-5,10,12,16-tetraene-21,2'-oxane]-3-one
0
(1S,5'R,6'R,10Z,12Z,14S,15S,16Z,19R,21S)-6'-[(2S)-butan-2-yl]-7,15-dihydroxy-5',6,10,14,16-pentamethylspiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-4(9),5,7,10,12,16-hexaene-21,2'-oxane]-3,4'-dione
0
27-formaldehyde-milbemycin beta14
0
4,25-diethyl-4,25-demethyl-milbemycin beta3
0
5-Oxoavermectin "2a" aglycone
0
5-Oxoavermectin "2b" aglycone
0
5-Oxoavermectin ''2a'' aglycone
0
6,8a-Seco-6,8a-deoxy-2,5-didehydroaverme
0
6,8a-Seco-6,8a-deoxy-5-oxoavermectin''2b''aglycone
0
6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone
0
Delta-2-Ivermectin B1a
0
Doramectin congener 1
0
Doramectin congener 3
0
Ivermectin B1 aglycone
0
Ivermectin monosaccharide
0
LL-F28249 beta
0
LL-F28249alpha
0
LL-F28249gamma
0
LSM-1593
0
LSM-1662
0
LSM-5397
0
Milbemycin A3 oxime
0
Milbemycin A4 oxime
0
Milbemycin J
0
Milbemycin K
0
Milbemycin alpha20
0
Milbemycin alpha21
0
Milbemycin alpha22
0
Milbemycin alpha23
0
Milbemycin alpha24
0
Milbemycin alpha25
0
Milbemycin alpha26
0
Milbemycin alpha27
0
Milbemycin alpha28
0
Milbemycin alpha29
0
Milbemycin alpha30
0
Milbemycin beta10
0
Milbemycin beta11
0
Milbemycin beta12
0
Milbemycin beta13
0
Milbemycin beta14
0
Milbemycin beta3
0
Milbemycin beta9
0
Milbemycin oxime
0
Moxidectin
0
Nemadectin
1
Selamectin
9
Tenvermectin C
0
Tenvermectin D
0
UK-78,624
0
UK-78614
0
UK-78618
0
UK-78621
0
UK-78629
0
UK-78630
0
UK-79465
0
VM 44857
0
VM 44864
0
VM 44865
0
VM 44866
0
VM-44857
0
VM-44864
0
VM-44865
0
VM-44866
0
VM44867
0
VM44868
0
VM47704
0
VM48130
0
VM48633
0
VM48640
0
VM48641
0
VM48642
0
VM54168
0
VM54339
0
[(3'R,4S,5'R,6S,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-3',21,24-trihydroxy-5',11,13,22-tetramethyl-12-(2-methylpropanoyloxy)-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-4'-yl] 2-methylpropanoate
0
[(4S,5'S,6R,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-12-yl] 2-methylpropanoate
0
epi-Ivermectin B1a
0
milbemycin A3 +
0
milbemycin A4 +
0
milbemycin D
0
Path 2
CHEBI ontology
19918
subatomic particle
19916
composite particle
19916
hadron
19916
baryon
19916
nucleon
19916
atomic nucleus
19916
atom
19916
main group element atom
19866
p-block element atom
19866
carbon group element atom
19811
carbon atom
19806
organic molecular entity
19806
organic group
18995
organic divalent group
18969
organodiyl group
18969
carbonyl group
18922
carbonyl compound
18922
carboxylic ester
16506
lactone
12533
macrocyclic lactone
5926
macrolide
5864
avermectin analogue
10
milbemycin
10
(1R,4S,4'S,5'S,6R,6'S,8R,10E,13R,14E,16Z,20R,21R,24S)-4',21,24-trihydroxy-5',11,13,22-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2,18-dione
0
(1S,4R,4'S,5'S,6'S,7R,8R,9S,10E,12E,14R,16E,19R,21R)-4',8,9-trihydroxy-10-(hydroxymethyl)-7-methoxy-5',6,14,16-tetramethyl-6'-[(E)-4-methylpent-2-en-2-yl]spiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-5,10,12,16-tetraene-21,2'-oxane]-3-one
0
(1S,5'R,6'R,10Z,12Z,14S,15S,16Z,19R,21S)-6'-[(2S)-butan-2-yl]-7,15-dihydroxy-5',6,10,14,16-pentamethylspiro[2,20-dioxatricyclo[17.3.1.04,9]tricosa-4(9),5,7,10,12,16-hexaene-21,2'-oxane]-3,4'-dione
0
27-formaldehyde-milbemycin beta14
0
4,25-diethyl-4,25-demethyl-milbemycin beta3
0
5-Oxoavermectin "2a" aglycone
0
5-Oxoavermectin "2b" aglycone
0
5-Oxoavermectin ''2a'' aglycone
0
6,8a-Seco-6,8a-deoxy-2,5-didehydroaverme
0
6,8a-Seco-6,8a-deoxy-5-oxoavermectin''2b''aglycone
0
6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone
0
Delta-2-Ivermectin B1a
0
Doramectin congener 1
0
Doramectin congener 3
0
Ivermectin B1 aglycone
0
Ivermectin monosaccharide
0
LL-F28249 beta
0
LL-F28249alpha
0
LL-F28249gamma
0
LSM-1593
0
LSM-1662
0
LSM-5397
0
Milbemycin A3 oxime
0
Milbemycin A4 oxime
0
Milbemycin J
0
Milbemycin K
0
Milbemycin alpha20
0
Milbemycin alpha21
0
Milbemycin alpha22
0
Milbemycin alpha23
0
Milbemycin alpha24
0
Milbemycin alpha25
0
Milbemycin alpha26
0
Milbemycin alpha27
0
Milbemycin alpha28
0
Milbemycin alpha29
0
Milbemycin alpha30
0
Milbemycin beta10
0
Milbemycin beta11
0
Milbemycin beta12
0
Milbemycin beta13
0
Milbemycin beta14
0
Milbemycin beta3
0
Milbemycin beta9
0
Milbemycin oxime
0
Moxidectin
0
Nemadectin
1
Selamectin
9
Tenvermectin C
0
Tenvermectin D
0
UK-78,624
0
UK-78614
0
UK-78618
0
UK-78621
0
UK-78629
0
UK-78630
0
UK-79465
0
VM 44857
0
VM 44864
0
VM 44865
0
VM 44866
0
VM-44857
0
VM-44864
0
VM-44865
0
VM-44866
0
VM44867
0
VM44868
0
VM47704
0
VM48130
0
VM48633
0
VM48640
0
VM48641
0
VM48642
0
VM54168
0
VM54339
0
[(3'R,4S,5'R,6S,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-3',21,24-trihydroxy-5',11,13,22-tetramethyl-12-(2-methylpropanoyloxy)-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-4'-yl] 2-methylpropanoate
0
[(4S,5'S,6R,6'S,8R,10E,13S,14E,16E,20R,21R,24S)-6'-[(E)-but-2-en-2-yl]-21,24-dihydroxy-5',11,13,22-tetramethyl-2-oxospiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-12-yl] 2-methylpropanoate
0
epi-Ivermectin B1a
0
milbemycin A3 +
0
milbemycin A4 +
0
milbemycin D
0