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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:milbemycin
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Accession:CHEBI:50345 term browser browse the term
Synonyms:related_synonym: milbemycins
 xref_mesh: MESH:C027837
 xref: Wikipedia:Milbemycin



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milbemycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
decreases expression
ISO moxidectin results in decreased activity of ABCB1A protein
moxidectin results in decreased expression of ABCB1 protein
CTD PMID:17134887 PMID:21458446 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases export
multiple interactions
ISO ABCG2 protein results in increased export of moxidectin
tryptoquivaline inhibits the reaction [ABCG2 protein results in increased export of moxidectin]
CTD PMID:19428349 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ano1 anoctamin 1 decreases activity ISO moxidectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO moxidectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; moxidectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; moxidectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
Selamectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions
ISO selamectin results in decreased activity of ABCB1A protein
[ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to selamectin
CTD PMID:17134887 PMID:19161460 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions ISO [ABCB1A protein co-treated with ABCB1B protein] affects the susceptibility to selamectin CTD PMID:19161460 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Ano1 anoctamin 1 decreases activity ISO selamectin results in decreased activity of ANO1 protein CTD PMID:32201246 NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069
JBrowse link
G Cdh1 cadherin 1 increases expression ISO selamectin results in increased expression of CDH1 CTD PMID:26078298 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO selamectin results in increased expression of ESR1 CTD PMID:26078298 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Mxd1 max dimerization protein 1 multiple interactions ISO selamectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO selamectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; selamectin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; selamectin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions ISO selamectin inhibits the reaction [MXD1 protein binds to SIN3A protein] CTD PMID:26078298 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      biological role 19757
        biochemical role 19377
          metabolite 19352
            prokaryotic metabolite 18418
              bacterial metabolite 18418
                milbemycin 10
                  5-Oxoavermectin "2a" aglycone 0
                  5-Oxoavermectin "2b" aglycone 0
                  6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone 0
                  LL-F28249 beta 0
                  LSM-1593 0
                  LSM-1662 0
                  LSM-5397 0
                  Selamectin 9
                  VM 44857 0
                  VM 44864 0
                  VM 44865 0
                  VM 44866 0
                  milbemycin A3 + 0
                  milbemycin A4 + 0
                  milbemycin D 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic ester 15892
                                        lactone 11245
                                          macrocyclic lactone 5531
                                            macrolide 5479
                                              avermectin analogue 10
                                                milbemycin 10
                                                  5-Oxoavermectin "2a" aglycone 0
                                                  5-Oxoavermectin "2b" aglycone 0
                                                  6,8a-seco-6,8a-deoxy-5-oxoavermectin "2a" aglycone 0
                                                  LL-F28249 beta 0
                                                  LSM-1593 0
                                                  LSM-1662 0
                                                  LSM-5397 0
                                                  Selamectin 9
                                                  VM 44857 0
                                                  VM 44864 0
                                                  VM 44865 0
                                                  VM 44866 0
                                                  milbemycin A3 + 0
                                                  milbemycin A4 + 0
                                                  milbemycin D 0
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