CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2-amino-2-oxoethyl group
Accession: CHEBI:50330
browse the term
Synonyms: exact_synonym: 2-amino-2-oxoethyl
related_synonym: Formula=C2H4NO; SMILES=C(=O)(C*)N; asparagine side-chain
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Egf
epidermal growth factor
multiple interactions
EXP
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine]
CTD
PMID:22689575
NCBI chr 2:68,820,616...68,895,537
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions decreases activity
ISO
Saquinavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Saquinavir results in decreased activity of ABCB11 protein
CTD
PMID:20829430 PMID:23956101 PMID:24014644
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
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Abcb1a
ATP binding cassette subfamily B member 1A
increases export affects uptake affects export
ISO
ABCB1 protein results in increased export of Saquinavir ABCB1A protein affects the uptake of Saquinavir ABCB1 protein affects the export of Saquinavir
CTD
PMID:10562306 PMID:15832500 PMID:18535159
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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Abcb1b
ATP-binding cassette, subfamily B (MDR/TAP), member 1B
affects uptake
ISO
ABCB1B protein affects the uptake of Saquinavir
CTD
PMID:10562306
NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
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Abcc1
ATP binding cassette subfamily C member 1
increases export
ISO
ABCC1 protein results in increased export of Saquinavir
CTD
PMID:18535159
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Abcc2
ATP binding cassette subfamily C member 2
affects export multiple interactions increases export
ISO
ABCC2 protein affects the export of Saquinavir montelukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]; verlukast inhibits the reaction [ABCC2 protein results in increased export of Saquinavir]
CTD
PMID:15832500 PMID:18535159 PMID:19952419
NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
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Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression multiple interactions
ISO
Saquinavir results in decreased expression of ADIPOQ mRNA; Saquinavir results in decreased expression of ADIPOQ protein [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ADIPOQ mRNA; rosiglitazone inhibits the reaction [Saquinavir results in decreased secretion of ADIPOQ protein]
CTD
PMID:15865214 PMID:16931933
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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Aebp1
AE binding protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of AEBP1 mRNA
CTD
PMID:16931933
NCBI chr14:86,101,253...86,111,323
Ensembl chr14:86,101,277...86,111,306
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Alb
albumin
affects binding
ISO
Saquinavir binds to ALB protein
CTD
PMID:15814459 PMID:16336266
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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Alox5ap
arachidonate 5-lipoxygenase activating protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ALOX5AP mRNA
CTD
PMID:16931933
NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
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Arpp21
cAMP regulated phosphoprotein 21
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ARPP21 mRNA
CTD
PMID:16931933
NCBI chr 8:120,323,895...120,492,790
Ensembl chr 8:120,323,897...120,446,507
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Asic2
acid sensing ion channel subunit 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ASIC2 mRNA
CTD
PMID:16931933
NCBI chr10:68,247,800...69,347,223
Ensembl chr10:68,248,655...68,517,564
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Atf6
activating transcription factor 6
increases expression
ISO
Saquinavir results in increased expression of ATF6 protein
CTD
PMID:19147209
NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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C1r
complement C1r
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C1R mRNA
CTD
PMID:16931933
NCBI chr 4:157,126,060...157,136,825
Ensembl chr 4:157,125,998...157,136,829
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C3ar1
complement C3a receptor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA
CTD
PMID:16931933
NCBI chr 4:155,681,767...155,691,240
Ensembl chr 4:155,684,029...155,690,869
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Casp9
caspase 9
increases cleavage
ISO
Saquinavir results in increased cleavage of CASP9 protein
CTD
PMID:19147209
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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Cd36
CD36 molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CD36 mRNA
CTD
PMID:16931933
NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
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Cfd
complement factor D
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CFD mRNA
CTD
PMID:16931933
NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
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Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CIDEC mRNA
CTD
PMID:16931933
NCBI chr 4:145,377,482...145,390,497
Ensembl chr 4:145,377,431...145,390,497
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Clcn3
chloride voltage-gated channel 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of CLCN3 mRNA
CTD
PMID:16931933
NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
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Cybb
cytochrome b-245 beta chain
multiple interactions
ISO
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]
CTD
PMID:14871405
NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
Saquinavir results in increased expression of CYP1A1 mRNA
CTD
PMID:9860486
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
decreases activity multiple interactions increases metabolic processing
ISO
Saquinavir results in decreased activity of CYP3A4 protein Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein] CYP3A4 protein results in increased metabolism of Saquinavir
CTD
PMID:11824416 PMID:15523003
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Dcn
decorin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DCN mRNA
CTD
PMID:16931933
NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
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Dusp3
dual specificity phosphatase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of DUSP3 mRNA
CTD
PMID:16931933
NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
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Elovl3
ELOVL fatty acid elongase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ELOVL3 mRNA
CTD
PMID:16931933
NCBI chr 1:265,883,353...265,887,181
Ensembl chr 1:265,883,355...265,887,226
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Esr2
estrogen receptor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of ESR2 mRNA
CTD
PMID:16931933
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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Etv6
ETS variant transcription factor 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of ETV6 mRNA
CTD
PMID:16931933
NCBI chr 4:167,754,684...167,992,370
Ensembl chr 4:167,754,525...167,992,168
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Fads2
fatty acid desaturase 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of FADS2 mRNA
CTD
PMID:16931933
NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
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Faim
Fas apoptotic inhibitory molecule
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of FAIM mRNA
CTD
PMID:16931933
NCBI chr 8:107,225,119...107,247,228
Ensembl chr 8:107,225,212...107,241,224 Ensembl chr 8:107,225,212...107,241,224
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G0s2
G0/G1switch 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of G0S2 mRNA
CTD
PMID:16931933
NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
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Ganc
glucosidase, alpha; neutral C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of GANC mRNA
CTD
PMID:16931933
NCBI chr 3:112,173,907...112,226,886
Ensembl chr 3:112,173,907...112,226,023
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Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of GUCY1B1 mRNA
CTD
PMID:16931933
NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
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Hadh
hydroxyacyl-CoA dehydrogenase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of HADH mRNA
CTD
PMID:16931933
NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
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Hcn1
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of HCN1 mRNA
CTD
PMID:16931933
NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO
Saquinavir results in increased expression of HSPA5 protein
CTD
PMID:19147209
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
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Ikzf4
IKAROS family zinc finger 4
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of IKZF4 mRNA
CTD
PMID:16931933
NCBI chr 7:3,061,422...3,098,142
Ensembl chr 7:3,061,469...3,074,359
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Il6
interleukin 6
increases expression multiple interactions
ISO
Saquinavir results in increased expression of IL6 mRNA; Saquinavir results in increased expression of IL6 protein rosiglitazone inhibits the reaction [Saquinavir results in increased expression of IL6 mRNA] Saquinavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:15388451 PMID:15865214
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Ins2
insulin 2
multiple interactions
ISO
Saquinavir inhibits the reaction [INS protein results in increased import of Glucose]
CTD
PMID:11786383
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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Klhl28
kelch-like family member 28
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of KLHL28 mRNA
CTD
PMID:16931933
NCBI chr 6:86,680,826...86,713,370
Ensembl chr 6:86,684,413...86,713,370
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Lamc2
laminin subunit gamma 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of LAMC2 mRNA
CTD
PMID:16931933
NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
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Lef1
lymphoid enhancer binding factor 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEF1 mRNA
CTD
PMID:16931933
NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
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Lep
leptin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of LEP mRNA
CTD
PMID:16931933
NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
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Lpl
lipoprotein lipase
decreases activity decreases expression
ISO
Saquinavir results in decreased activity of LPL protein Saquinavir results in decreased expression of LPL mRNA
CTD
PMID:11741158 PMID:11786383
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
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Me1
malic enzyme 1
decreases expression
ISO
Saquinavir results in decreased expression of ME1 mRNA
CTD
PMID:11741158
NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
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Mgat4c
MGAT4 family, member C
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MGAT4C mRNA
CTD
PMID:16931933
NCBI chr 7:43,249,369...44,024,278
Ensembl chr 7:44,009,069...44,024,456
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Mrap
melanocortin 2 receptor accessory protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of MRAP mRNA
CTD
PMID:16931933
NCBI chr11:30,904,733...30,915,225
Ensembl chr11:30,904,733...30,915,225
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Myod1
myogenic differentiation 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of MYOD1 mRNA
CTD
PMID:16931933
NCBI chr 1:102,396,538...102,399,248
Ensembl chr 1:102,396,538...102,399,248
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Nap1l5
nucleosome assembly protein 1-like 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NAP1L5 mRNA
CTD
PMID:16931933
NCBI chr 4:89,149,314...89,152,511
Ensembl chr 4:89,149,317...89,151,184
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Noct
nocturnin
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of NOCT mRNA
CTD
PMID:16931933
NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
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Notch4
notch receptor 4
multiple interactions decreases expression
EXP
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of NOTCH4 protein] Saquinavir results in decreased expression of NOTCH4 protein
CTD
PMID:20722969
NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
NR1I2 gene promotes the reaction [Rifampin results in increased metabolism of Saquinavir]
CTD
PMID:18799805
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Nup210
nucleoporin 210
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of NUP210 mRNA
CTD
PMID:16931933
NCBI chr 4:122,643,952...122,741,322
Ensembl chr 4:122,644,135...122,741,110
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Oaz3
ornithine decarboxylase antizyme 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of OAZ3 mRNA
CTD
PMID:16931933
NCBI chr 2:195,675,925...195,678,859
Ensembl chr 2:195,676,048...195,678,848
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Pcdh15
protocadherin related 15
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PCDH15 mRNA
CTD
PMID:16931933
NCBI chr20:14,952,213...15,334,745
Ensembl chr20:14,952,213...15,334,745
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Pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA
CTD
PMID:16931933
NCBI chr17:70,632,778...70,713,736
Ensembl chr17:70,684,134...70,713,726
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Phf6
PHD finger protein 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PHF6 mRNA
CTD
PMID:16931933
NCBI chr X:158,698,353...158,739,855
Ensembl chr X:158,698,356...158,739,838 Ensembl chr X:158,698,356...158,739,838
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Pidd1
p53-induced death domain protein 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIDD1 mRNA
CTD
PMID:16931933
NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
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Piwil2
piwi-like RNA-mediated gene silencing 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PIWIL2 mRNA
CTD
PMID:16931933
NCBI chr15:52,037,693...52,116,277
Ensembl chr15:52,037,693...52,116,001
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Pon1
paraoxonase 1
decreases activity
EXP
Saquinavir results in decreased activity of PON1 protein
CTD
PMID:27378623
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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Porcn
porcupine O-acyltransferase
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PPN mRNA
CTD
PMID:16931933
NCBI chr X:15,035,569...15,048,440
Ensembl chr X:15,035,569...15,048,440
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Pou5f1
POU class 5 homeobox 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of POU5F1 mRNA
CTD
PMID:16931933
NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
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Prdm1
PR/SET domain 1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of PRDM1 mRNA
CTD
PMID:16931933
NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
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Reep6
receptor accessory protein 6
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of REEP6 mRNA
CTD
PMID:16931933
NCBI chr 7:12,240,059...12,246,814
Ensembl chr 7:12,240,060...12,246,729
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RGD1562378
histone H4 variant H4-v.1
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of H4C9 mRNA
CTD
PMID:16931933
NCBI chr 4:170,762,862...170,763,962
Ensembl chr 4:170,763,605...170,763,916
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Rnf151
ring finger protein 151
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of RNF151 mRNA
CTD
PMID:16931933
NCBI chr10:14,083,538...14,088,011
Ensembl chr10:14,083,538...14,085,855
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Rpain
RPA interacting protein
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA
CTD
PMID:16931933
NCBI chr10:57,606,287...57,613,834
Ensembl chr10:57,606,650...57,613,747
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RT1-CE5
RT1 class I, locus CE5
affects expression
ISO
Saquinavir affects the expression of HLA-F mRNA
CTD
PMID:25811541
NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
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RT1-DOa
RT1 class II, locus DOa
affects expression
ISO
Saquinavir affects the expression of HLA-DOA mRNA
CTD
PMID:25811541
NCBI chr20:3,889,106...3,892,360
Ensembl chr20:3,889,370...3,892,449
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S100a8
S100 calcium binding protein A8
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of S100A8 mRNA
CTD
PMID:16931933
NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
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Slco1a4
solute carrier organic anion transporter family, member 1a4
affects uptake
ISO
SLCO1A2 protein affects the uptake of Saquinavir
CTD
PMID:15832500
NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
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Sod2
superoxide dismutase 2
multiple interactions
ISO
Saquinavir inhibits the reaction [Morphine results in increased expression of SOD2 protein]
CTD
PMID:14871405
NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
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Spink5
serine peptidase inhibitor, Kazal type 5
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of SPINK5 mRNA
CTD
PMID:16931933
NCBI chr18:35,118,300...35,190,458
Ensembl chr18:35,121,967...35,191,069 Ensembl chr 1:35,121,967...35,191,069
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Sv2b
synaptic vesicle glycoprotein 2b
affects response to substance
ISO
SV2B gene SNP affects the susceptibility to Saquinavir
CTD
PMID:25622337
NCBI chr 1:136,664,199...136,842,247
Ensembl chr 1:136,664,204...136,842,247
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Timp2
TIMP metallopeptidase inhibitor 2
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TIMP2 mRNA
CTD
PMID:16931933
NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
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Tjp1
tight junction protein 1
multiple interactions decreases expression
EXP
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; [Saquinavir co-treated with Nicotine] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]; Vitamin E inhibits the reaction [[Nicotine co-treated with Saquinavir] results in decreased expression of TJP1 protein] Saquinavir results in decreased expression of TJP1 protein
CTD
PMID:20722969
NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
Saquinavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Saquinavir results in increased expression of TNF mRNA; Saquinavir results in increased expression of TNF protein rosiglitazone inhibits the reaction [Saquinavir results in increased expression of TNF mRNA]
CTD
PMID:15388451 PMID:15865214
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Trim42
tripartite motif-containing 42
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of TRIM42 mRNA
CTD
PMID:16931933
NCBI chr 8:105,205,041...105,226,541
Ensembl chr 8:105,204,993...105,226,588
G
Wnt10a
Wnt family member 10A
multiple interactions
ISO
[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of WNT10A mRNA
CTD
PMID:16931933
NCBI chr 9:82,053,581...82,066,047
Ensembl chr 9:82,053,581...82,066,047
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