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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 5.99.1.2 (DNA topoisomerase) inhibitor
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Accession:CHEBI:50276 term browser browse the term
Definition:A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC 5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA.
Synonyms:related_synonym: DNA topoisomerase inhibitor;   DNA topoisomerase inhibitors;   EC 5.99.1.2 (DNA topoisomerase) inhibitors;   EC 5.99.1.2 inhibitor;   EC 5.99.1.2 inhibitors;   topoisomerase I (EC 5.99.1.2) inhibitor;   topoisomerase I (EC 5.99.1.2) inhibitors;   topoisomerase I inhibitor;   topoisomerase I inhibitors;   type I DNA topoisomerase inhibitor;   type I DNA topoisomerase inhibitors


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      CHEBI ontology 19786
        role 19732
          biological role 19732
            biochemical role 19333
              enzyme inhibitor 18267
                EC 5.* (isomerase) inhibitor 6682
                  EC 5.99.* (other isomerases) inhibitor 6502
                    EC 5.99.1.* (miscellaneous isomerase) inhibitor 6502
                      topoisomerase inhibitor 6502
                        EC 5.99.1.2 (DNA topoisomerase) inhibitor 3763
                          (R)-homocamptothecin + 0
                          (S)-scoulerine + 0
                          SN-38 + 701
                          amarogentin 3
                          camptothecin 220
                          diflomotecan 0
                          dihydrobetulinic acid 0
                          disulfiram 579
                          ellagic acid + 131
                          feruloylagmatine + 0
                          irinotecan 701
                          irinotecan hydrochloride (anhydrous) + 0
                          irinotecan hydrochloride hydrate 0
                          kaempferol 3-O-(5-O-acetyl-alpha-D-apiofuranosyl)-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-galactopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-[alpha-L-rhamnopyranosyl(1->2)-beta-D-glucopyranosyl]-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-alpha-L-arabinopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-galactopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          kaempferol 3-O-beta-D-glucopyranosyl-7-O-alpha-L-rhamnopyranoside 0
                          lucanthone + 195
                          manoalide 3
                          methyl brevifolincarboxylate 0
                          morin 90
                          rubitecan 17
                          saintopin 0
                          topopyrone A 0
                          topopyrone B 0
                          topopyrone C 0
                          topopyrone D 0
                          topotecan 2700
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