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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.1.1 (alcohol dehydrogenase) inhibitor
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Accession:CHEBI:50269 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of alcohol dehydrogenase (EC 1.1.1.1).
Synonyms:related_synonym: ADH inhibitor;   ADH inhibitors;   EC 1.1.1.1 inhibitor;   EC 1.1.1.1 inhibitors;   NAD-dependent alcohol dehydrogenase inhibitor;   NAD-dependent alcohol dehydrogenase inhibitors;   NAD-specific aromatic alcohol dehydrogenase inhibitor;   NAD-specific aromatic alcohol dehydrogenase inhibitors;   NADH-alcohol dehydrogenase inhibitor;   NADH-alcohol dehydrogenase inhibitors;   NADH-aldehyde dehydrogenase inhibitor;   NADH-aldehyde dehydrogenase inhibitors;   alcohol dehydrogenase (EC 1.1.1.1) inhibitors;   alcohol dehydrogenase (NAD) inhibitor;   alcohol dehydrogenase (NAD) inhibitors;   alcohol dehydrogenase inhibitor;   alcohol dehydrogenase inhibitors;   alcohol:NAD+ oxidoreductase inhibitor;   alcohol:NAD+ oxidoreductase inhibitors;   aldehyde reductase inhibitor;   aldehyde reductase inhibitors;   aliphatic alcohol dehydrogenase inhibitor;   aliphatic alcohol dehydrogenase inhibitors;   ethanol dehydrogenase inhibitor;   ethanol dehydrogenase inhibitors;   primary alcohol dehydrogenase inhibitor;   primary alcohol dehydrogenase inhibitors;   yeast alcohol dehydrogenase inhibitor;   yeast alcohol dehydrogenase inhibitors
 xref: Wikipedia:Alcohol_dehydrogenase


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fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1C (class I), gamma polypeptide decreases activity
multiple interactions		 ISO fomepizole results in decreased activity of ADH1 protein
fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]		 CTD PMID:7943667 PMID:21167143 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein] CTD PMID:29739258 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen affects the localization of BAX protein] CTD PMID:29739258 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 mRNA]; Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 protein] CTD PMID:19280452 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA] CTD PMID:9540844 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA] CTD PMID:20116195 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases activity
decreases activity		 ISO
EXP		 [Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride; Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
fomepizole results in increased expression of CYP2E1 protein
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride; fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]
fomepizole results in increased activity of CYP2E1 protein		 CTD PMID:1538706 PMID:3113478 PMID:3782137 PMID:8074729 PMID:8531136 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP fomepizole promotes the reaction [Ethanol results in increased expression of CYP4A1 protein]
fomepizole results in increased expression of CYP4A1 protein		 CTD PMID:20116195 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Fomepizole inhibits the reaction [Acetaminophen affects the localization of DIABLO protein] CTD PMID:29739258 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]]
Fomepizole inhibits the reaction [Acetaminophen results in increased activity of GPT protein]; Fomepizole inhibits the reaction [leupeptin promotes the reaction [Acetaminophen results in increased activity of GPT protein]]		 CTD PMID:11394713 PMID:29739258 PMID:33458793 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] CTD PMID:16737972 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 EXP Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; fomepizole inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:20116195 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein] CTD PMID:24492484 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:18317950 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:18317950 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects binding
multiple interactions		 ISO Fomepizole binds to MAPK8 protein
Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]		 CTD PMID:29739258 PMID:30903181 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects binding ISO Fomepizole binds to MAPK9 protein CTD PMID:30903181 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA] CTD PMID:20116195 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdyn prodynorphin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA] CTD PMID:17934066 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA] CTD PMID:17934066 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] CTD PMID:17030193 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP fomepizole inhibits the reaction [allyl alcohol affects the localization of PRKCD protein] CTD PMID:12755590 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA] CTD PMID:20116195 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA] CTD PMID:20116195 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20026
      biological role 20025
        biochemical role 19665
          enzyme inhibitor 18607
            EC 1.* (oxidoreductase) inhibitor 17180
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 5856
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 4155
                  EC 1.1.1.1 (alcohol dehydrogenase) inhibitor 31
                    dodecanedioic acid + 0
                    fomepizole 31
paths to the root