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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 1.1.1.1 (alcohol dehydrogenase) inhibitor
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Accession:CHEBI:50269 term browser browse the term
Definition:An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of alcohol dehydrogenase (EC 1.1.1.1).
Synonyms:related_synonym: ADH inhibitor;   ADH inhibitors;   EC 1.1.1.1 inhibitor;   EC 1.1.1.1 inhibitors;   NAD-dependent alcohol dehydrogenase inhibitor;   NAD-dependent alcohol dehydrogenase inhibitors;   NAD-specific aromatic alcohol dehydrogenase inhibitor;   NAD-specific aromatic alcohol dehydrogenase inhibitors;   NADH-alcohol dehydrogenase inhibitor;   NADH-alcohol dehydrogenase inhibitors;   NADH-aldehyde dehydrogenase inhibitor;   NADH-aldehyde dehydrogenase inhibitors;   alcohol dehydrogenase (EC 1.1.1.1) inhibitors;   alcohol dehydrogenase (NAD) inhibitor;   alcohol dehydrogenase (NAD) inhibitors;   alcohol dehydrogenase inhibitor;   alcohol dehydrogenase inhibitors;   alcohol:NAD+ oxidoreductase inhibitor;   alcohol:NAD+ oxidoreductase inhibitors;   aldehyde reductase inhibitor;   aldehyde reductase inhibitors;   aliphatic alcohol dehydrogenase inhibitor;   aliphatic alcohol dehydrogenase inhibitors;   ethanol dehydrogenase inhibitor;   ethanol dehydrogenase inhibitors;   primary alcohol dehydrogenase inhibitor;   primary alcohol dehydrogenase inhibitors;   yeast alcohol dehydrogenase inhibitor;   yeast alcohol dehydrogenase inhibitors
 xref: Wikipedia:Alcohol_dehydrogenase

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dodecanedioic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO dodecanedioic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:243,728,500...243,740,907
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1 alcohol dehydrogenase 1 (class I) decreases activity
multiple interactions		 ISO fomepizole results in decreased activity of ADH1 protein
fomepizole inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]		 CTD PMID:7943667 PMID:21167143 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO fomepizole inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:21167143 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 mRNA]; Fomepizole inhibits the reaction [Ethanol results in increased expression of CCN2 protein] CTD PMID:19280452 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of COL1A1 mRNA] CTD PMID:9540844 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of CXCL2 mRNA] CTD PMID:20116195 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
increases expression
increases activity		 ISO
EXP		 [Fomepizole results in decreased activity of CYP2E1 protein] which results in decreased metabolism of vinyl fluoride; Fomepizole inhibits the reaction [[CYP2E1 protein results in increased metabolism of Ethanol] which results in increased abundance of Reactive Oxygen Species]; Fomepizole inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Fomepizole inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein]; Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of 2,6-xylidine metabolite]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 6-hydroxychlorzoxazone]; Fomepizole inhibits the reaction [CYP2E1 protein results in increased metabolism of Chlorzoxazone]
fomepizole results in increased expression of CYP2E1 protein
fomepizole results in increased activity of CYP2E1 protein
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride
[fomepizole results in decreased activity of CYP2E1 protein] which results in decreased uptake of vinyl fluoride; fomepizole promotes the reaction [CYP2E1 protein results in increased metabolism of methylformamide]		 CTD PMID:1538706 PMID:3113478 PMID:3782137 PMID:8074729 PMID:8531136 PMID:9073601 PMID:9143349 PMID:11409937 PMID:18845238 PMID:21336516 PMID:21915887 PMID:24561005 PMID:33253783 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP fomepizole promotes the reaction [Ethanol results in increased expression of CYP4A1 protein]
fomepizole results in increased expression of CYP4A1 protein		 CTD PMID:20116195 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP fomepizole inhibits the reaction [Caffeine promotes the reaction [allyl alcohol results in increased activity of GPT protein]] CTD PMID:11394713 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of HAMP mRNA] CTD PMID:16737972 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression		 EXP Ethanol inhibits the reaction [fomepizole results in decreased expression of IL4 mRNA]; fomepizole inhibits the reaction [Ethanol results in decreased expression of IL4 mRNA] CTD PMID:20116195 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein] CTD PMID:24492484 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK1 protein] CTD PMID:18317950 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased phosphorylation of MAPK3 protein] CTD PMID:18317950 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects binding
multiple interactions		 ISO Fomepizole binds to MAPK8 protein
Fomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]		 CTD PMID:30903181 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 affects binding ISO Fomepizole binds to MAPK9 protein CTD PMID:30903181 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of OPRK1 mRNA] CTD PMID:17934066 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA] CTD PMID:20116195 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381 		JBrowse link
G Pdyn prodynorphin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA] CTD PMID:17934066 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671 		JBrowse link
G Penk proenkephalin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of PENK mRNA] CTD PMID:17934066 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837 		JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO fomepizole inhibits the reaction [Ethanol results in decreased expression of POMC mRNA] CTD PMID:17934066 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in decreased activity of PPARA protein] CTD PMID:11022051 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fomepizole inhibits the reaction [Ethanol inhibits the reaction [rosiglitazone results in increased activity of PPARG protein]] CTD PMID:17030193 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP fomepizole inhibits the reaction [allyl alcohol affects the localization of PRKCD protein] CTD PMID:12755590 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA] CTD PMID:20116195 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trib3 tribbles pseudokinase 3 multiple interactions EXP fomepizole inhibits the reaction [Ethanol results in increased expression of TRIB3 mRNA] CTD PMID:20116195 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        biochemical role 19323
          enzyme inhibitor 18261
            EC 1.* (oxidoreductase) inhibitor 16651
              EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor 5830
                EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 4121
                  EC 1.1.1.1 (alcohol dehydrogenase) inhibitor 29
                    dodecanedioic acid + 1
                    fomepizole 28
paths to the root