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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxydicarboxylic acid
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Accession:CHEBI:50263 term browser browse the term
Definition:Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.
Synonyms:related_synonym: 2-hydroxydicarboxylic acids;   Formula=C3H4O5(CH2)n
 alt_id: CHEBI:1154;   CHEBI:19636
 xref: KEGG:C03668
 cyclic_relationship: is_conjugate_acid_of CHEBI:167114


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2-hydroxyglutaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH2 protein CTD PMID:28269980 NCBI chr 5:114,261,987...114,268,782
Ensembl chr 5:114,261,987...114,266,279 		JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase decreases activity ISO alpha-hydroxyglutarate results in decreased activity of ALKBH3 protein CTD PMID:28269980 NCBI chr 2:93,810,979...93,841,099
Ensembl chr 2:93,810,895...93,841,152 		JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase increases metabolic processing ISO D2HGDH protein results in increased metabolism of alpha-hydroxyglutarate CTD PMID:15609246 NCBI chr 1:93,752,531...93,781,583
Ensembl chr 1:93,752,631...93,780,070 		JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO [epigallocatechin gallate results in decreased expression of GLUD1 protein] which results in decreased abundance of alpha-hydroxyglutarate CTD PMID:31857147 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222 		JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble affects abundance ISO IDH1 gene mutant form affects the abundance of alpha-hydroxyglutarate CTD PMID:22057236 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions		 EXP IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate]		 CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G L2hgdh L-2-hydroxyglutarate dehydrogenase increases abundance ISO L2HGDH gene mutant form results in increased abundance of alpha-hydroxyglutarate CTD PMID:25800467 NCBI chr12:69,737,210...69,771,648
Ensembl chr12:69,737,207...69,771,647 		JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle, aorta affects expression EXP diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression EXP diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr 2:113,877,763...113,883,356
Ensembl chr 2:113,877,763...113,884,029 		JBrowse link
G Actn3 actinin alpha 3 affects expression EXP diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr19:4,911,244...4,927,937
Ensembl chr19:4,911,244...4,927,937 		JBrowse link
G Adcy1 adenylate cyclase 1 affects expression EXP diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506 		JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression EXP diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459 		JBrowse link
G Agt angiotensinogen affects expression EXP diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP diethyl malate affects the expression of ALDH1A7 mRNA CTD PMID:24814887 NCBI chr19:20,670,318...20,704,920
Ensembl chr19:20,670,317...20,704,926 		JBrowse link
G C3 complement component 3 affects expression EXP diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit affects expression EXP diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr 2:14,608,672...14,993,622
Ensembl chr 2:14,607,899...14,992,719 		JBrowse link
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit affects expression EXP diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 2:52,318,332...52,566,816
Ensembl chr 2:52,318,337...52,566,843 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
affects expression		 EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Cbr2 carbonyl reductase 2 affects expression EXP diethyl malate affects the expression of CBR2 mRNA CTD PMID:24814887 NCBI chr11:120,620,311...120,622,851
Ensembl chr11:120,620,315...120,622,940 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 affects expression EXP diethyl malate affects the expression of CCL20 mRNA CTD PMID:24814887 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccl6 C-C motif chemokine ligand 6 affects expression EXP diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression EXP diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351 		JBrowse link
G Ccl9 C-C motif chemokine ligand 9 affects expression EXP diethyl malate affects the expression of CCL9 mRNA CTD PMID:24814887 NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462 		JBrowse link
G Col11a1 collagen, type XI, alpha 1 affects expression EXP diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367 		JBrowse link
G Col2a1 collagen, type II, alpha 1 affects expression EXP diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Col3a1 collagen, type III, alpha 1 affects expression EXP diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Col6a1 collagen, type VI, alpha 1 affects expression EXP diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr10:76,544,626...76,561,869
Ensembl chr10:76,544,626...76,562,002 		JBrowse link
G Comp cartilage oligomeric matrix protein affects expression EXP diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr 8:70,826,186...70,834,721
Ensembl chr 8:70,826,208...70,834,716 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions		 EXP diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]		 CTD PMID:24814887 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 affects expression EXP diethyl malate affects the expression of CXCL5 mRNA CTD PMID:24814887 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression EXP diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 affects expression EXP diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815 		JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression EXP diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr 9:66,065,364...66,179,524
Ensembl chr 9:66,065,505...66,179,524 		JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects expression EXP diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779 		JBrowse link
G Dhx58 DExH-box helicase 58 affects expression EXP diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr11:100,585,710...100,595,165
Ensembl chr11:100,585,710...100,595,097 		JBrowse link
G Edar ectodysplasin-A receptor affects expression EXP diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr10:58,436,602...58,511,518
Ensembl chr10:58,436,611...58,511,476 		JBrowse link
G Ednra endothelin receptor type A affects expression EXP diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr 8:78,389,658...78,451,081
Ensembl chr 8:78,389,660...78,451,093 		JBrowse link
G Epas1 endothelial PAS domain protein 1 affects expression EXP diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G Epha7 Eph receptor A7 affects expression EXP diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 4:28,811,840...28,969,391
Ensembl chr 4:28,813,131...28,967,499 		JBrowse link
G Ephb2 Eph receptor B2 affects expression EXP diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299 		JBrowse link
G Ephb6 Eph receptor B6 affects expression EXP diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443 		JBrowse link
G Fgf10 fibroblast growth factor 10 affects expression EXP diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651 		JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions
affects expression		 EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects expression EXP diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Fst follistatin affects expression EXP diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr13:114,588,798...114,595,522
Ensembl chr13:114,588,826...114,595,487 		JBrowse link
G Fzd2 frizzled class receptor 2 affects expression EXP diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884 		JBrowse link
G Fzd7 frizzled class receptor 7 affects expression EXP diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 1:59,521,306...59,526,114
Ensembl chr 1:59,521,583...59,526,114 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression EXP diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions
affects expression		 EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Ggt6 gamma-glutamyltransferase 6 affects expression EXP diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr11:72,326,067...72,329,392
Ensembl chr11:72,326,352...72,329,226 		JBrowse link
G Gli2 GLI-Kruppel family member GLI2 affects expression EXP diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349 		JBrowse link
G Gnao1 guanine nucleotide binding protein, alpha O affects expression EXP diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr 8:94,537,213...94,696,016
Ensembl chr 8:94,536,594...94,696,016 		JBrowse link
G Gng7 guanine nucleotide binding protein (G protein), gamma 7 affects expression EXP diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr10:80,784,463...80,850,742
Ensembl chr10:80,784,458...80,850,779 		JBrowse link
G Gsr glutathione reductase affects expression EXP diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gss glutathione synthetase multiple interactions
affects expression		 EXP S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730 		JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 affects expression
multiple interactions		 EXP diethyl malate affects the expression of GSTA1 mRNA; diethyl malate affects the expression of GSTA3 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]; S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA3 mRNA]		 CTD PMID:24814887 NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 affects expression EXP diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 affects expression EXP diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G H2-DMb1 histocompatibility 2, class II, locus Mb1 affects expression EXP diethyl malate affects the expression of H2-DMB1 mRNA CTD PMID:24814887 NCBI chr17:34,372,165...34,379,203
Ensembl chr17:34,372,046...34,379,204 		JBrowse link
G H2-M3 histocompatibility 2, M region locus 3 affects expression EXP diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G Hck hemopoietic cell kinase affects expression EXP diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr 2:152,950,388...152,993,361
Ensembl chr 2:152,950,388...152,993,361 		JBrowse link
G Hgf hepatocyte growth factor affects expression EXP diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression EXP diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Il15 interleukin 15 affects expression EXP diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr 8:83,058,253...83,129,883
Ensembl chr 8:83,058,261...83,129,851 		JBrowse link
G Il18 interleukin 18 affects expression EXP diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 affects expression EXP diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr 7:110,467,464...110,582,116
Ensembl chr 7:110,467,473...110,581,668 		JBrowse link
G Irf7 interferon regulatory factor 7 affects expression EXP diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression EXP diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253 		JBrowse link
G Itga11 integrin alpha 11 affects expression EXP diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr 9:62,585,137...62,691,618
Ensembl chr 9:62,585,108...62,691,264 		JBrowse link
G Itga3 integrin alpha 3 affects expression EXP diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr11:94,935,301...94,967,637
Ensembl chr11:94,935,300...94,967,627 		JBrowse link
G Kcnmb4 potassium large conductance calcium-activated channel, subfamily M, beta member 4 affects expression EXP diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr10:116,251,951...116,309,787
Ensembl chr10:116,253,766...116,309,783 		JBrowse link
G Lama1 laminin, alpha 1 affects expression EXP diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642 		JBrowse link
G Lama4 laminin, alpha 4 affects expression EXP diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 affects phosphorylation
multiple interactions		 EXP diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]		 CTD PMID:24814887 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 affects phosphorylation
multiple interactions		 EXP diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]		 CTD PMID:24814887 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Myl9 myosin, light polypeptide 9, regulatory affects expression EXP diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578 		JBrowse link
G Odc1 ornithine decarboxylase, structural 1 affects expression EXP diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr12:17,594,906...17,601,503
Ensembl chr12:17,594,795...17,601,506 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide affects expression
multiple interactions		 EXP diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]		 CTD PMID:24814887 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pdgfd platelet-derived growth factor, D polypeptide affects expression EXP diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr 9:6,168,377...6,534,284
Ensembl chr 9:6,168,584...6,378,850 		JBrowse link
G Pf4 platelet factor 4 affects expression EXP diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 affects expression EXP diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr11:3,280,731...3,292,971
Ensembl chr11:3,280,401...3,292,971 		JBrowse link
G Plxnc1 plexin C1 affects expression EXP diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr10:94,626,728...94,780,875
Ensembl chr10:94,626,728...94,780,697 		JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I affects expression EXP diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr19:30,541,887...31,742,675
Ensembl chr19:30,541,889...31,742,433 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase affects expression EXP diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ramp2 receptor (calcitonin) activity modifying protein 2 affects expression EXP diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr11:101,137,160...101,139,076
Ensembl chr11:101,136,854...101,150,372 		JBrowse link
G Rgs3 regulator of G-protein signaling 3 affects expression EXP diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 4:62,478,079...62,621,256
Ensembl chr 4:62,478,084...62,622,238 		JBrowse link
G Rigi RNA sensor RIG-I affects expression EXP diethyl malate affects the expression of RIGI mRNA CTD PMID:24814887 NCBI chr 4:40,203,775...40,239,843
Ensembl chr 4:40,203,773...40,239,828 		JBrowse link
G Runx1t1 RUNX1 translocation partner 1 affects expression EXP diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 4:13,742,628...13,895,056
Ensembl chr 4:13,743,436...13,893,649 		JBrowse link
G Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B affects expression EXP diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 9:107,474,868...107,486,440
Ensembl chr 9:107,474,873...107,486,428 		JBrowse link
G Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G affects expression EXP diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr19:44,976,838...44,991,836
Ensembl chr19:44,977,540...44,991,836 		JBrowse link
G Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A affects expression EXP diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr15:32,244,959...32,696,487
Ensembl chr15:32,244,956...32,696,487 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression EXP diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression
multiple interactions		 EXP diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]		 CTD PMID:24814887 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186 		JBrowse link
G Thbs1 thrombospondin 1 affects expression EXP diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thbs2 thrombospondin 2 affects expression EXP diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr17:14,885,762...14,914,524
Ensembl chr17:14,885,762...14,914,497 		JBrowse link
G Tnc tenascin C affects expression EXP diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) affects expression EXP diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Tnnt1 troponin T1, skeletal, slow affects expression EXP diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr 7:4,507,568...4,518,974
Ensembl chr 7:4,507,569...4,519,381 		JBrowse link
G Tslp thymic stromal lymphopoietin affects expression EXP diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
malic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein] CTD PMID:24732427 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial decreases abundance
multiple interactions		 EXP IDH2 protein mutant form results in decreased abundance of malic acid
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid]		 CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) increases expression ISO malic acid deficiency results in increased expression of MDH1 mRNA CTD PMID:26811028 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid CTD PMID:28223344 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO malic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      group 22072
        inorganic group 21029
          oxo group 20172
            organic oxo compound 20172
              carbonyl compound 20172
                dicarboxylic acids and O-substituted derivatives 11349
                  dicarboxylic acid 11343
                    2-hydroxydicarboxylic acid 102
                      (2E,4Z)-2-hydroxymuconic acid 0
                      (2Z,4E)-2-hydroxymuconic acid 0
                      (R)-2-ethylmalic acid 0
                      (R)-3,3-dimethylmalic acid 0
                      2,3-dimethylmalic acid + 0
                      2-(omega-methylthio)alkylmalic acid + 0
                      2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
                      2-hydroxyadipic acid + 0
                      2-hydroxyglutaric acid + 7
                      2-hydroxyoctanedioic acid 0
                      2-phosphinomethylmalic acid 0
                      3-(omega-methylthio)alkylmalic acid + 0
                      3-ethylmalic acid 0
                      3-isopropylmalic acid + 0
                      5-dehydro-4-deoxy-D-glucaric acid 0
                      citramalic acid + 0
                      dihydroxyfumaric acid 0
                      malic acid + 96
                      phosphinomethylisomalic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbonyl compound 20172
                                    dicarboxylic acids and O-substituted derivatives 11349
                                      dicarboxylic acid 11343
                                        2-hydroxydicarboxylic acid 102
                                          (2E,4Z)-2-hydroxymuconic acid 0
                                          (2Z,4E)-2-hydroxymuconic acid 0
                                          (R)-2-ethylmalic acid 0
                                          (R)-3,3-dimethylmalic acid 0
                                          2,3-dimethylmalic acid + 0
                                          2-(omega-methylthio)alkylmalic acid + 0
                                          2-hydroxy-3-(2-methylidenecyclopropyl)butanedioic acid 0
                                          2-hydroxyadipic acid + 0
                                          2-hydroxyglutaric acid + 7
                                          2-hydroxyoctanedioic acid 0
                                          2-phosphinomethylmalic acid 0
                                          3-(omega-methylthio)alkylmalic acid + 0
                                          3-ethylmalic acid 0
                                          3-isopropylmalic acid + 0
                                          5-dehydro-4-deoxy-D-glucaric acid 0
                                          citramalic acid + 0
                                          dihydroxyfumaric acid 0
                                          malic acid + 96
                                          phosphinomethylisomalic acid 0
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