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ONTOLOGY REPORT - ANNOTATIONS


Term:(+)-dexrazoxane
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Accession:CHEBI:50223 term browser browse the term
Definition:A razoxane that has formula C11H16N4O4.
Synonyms:exact_synonym: 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione
 related_synonym: (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione;   (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane;   Dextrorazoxane;   Formula=C11H16N4O4;   InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1;   InChIKey=BMKDZUISNHGIBY-ZETCQYMHSA-N;   SMILES=C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1;   dexrazoxano;   dexrazoxanum
 xref: Beilstein:6658412 "Beilstein";   Beilstein:8441732 "Beilstein";   CAS:24584-09-6 "ChemIDplus";   DrugBank:DB00380;   Drug_Central:839 "DrugCentral";   KEGG:D03730;   LINCS:LSM-5248
 xref_mesh: MESH:D064730
 xref: Wikipedia:Dexrazoxane


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(+)-dexrazoxane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:6480464
G Acad9 acyl-CoA dehydrogenase family, member 9 JBrowse link 2 122,782,051 122,806,166 RGD:6480464
G Acadm acyl-CoA dehydrogenase medium chain JBrowse link 2 260,124,418 260,148,589 RGD:6480464
G Acadsb acyl-CoA dehydrogenase, short/branched chain JBrowse link 1 201,981,362 202,022,771 RGD:6480464
G Acot2 acyl-CoA thioesterase 2 JBrowse link 6 107,460,596 107,468,324 RGD:6480464
G Acot9 acyl-CoA thioesterase 9 JBrowse link X 43,543,069 43,592,200 RGD:6480464
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6480464
G Acsl1 acyl-CoA synthetase long-chain family member 1 JBrowse link 16 48,937,456 49,003,898 RGD:6480464
G Acss1 acyl-CoA synthetase short-chain family member 1 JBrowse link 3 146,420,346 146,470,293 RGD:6480464
G Ak4 adenylate kinase 4 JBrowse link 5 120,250,318 120,309,153 RGD:6480464
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 JBrowse link 5 158,090,238 158,115,725 RGD:6480464
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 JBrowse link 6 108,146,552 108,167,185 RGD:6480464
G Anxa10 annexin A10 JBrowse link 16 29,674,699 29,741,521 RGD:6480464
G Ass1 argininosuccinate synthase 1 JBrowse link 3 10,327,411 10,375,847 RGD:6480464
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:6480464
G Atp5f1b ATP synthase F1 subunit beta JBrowse link 7 2,504,708 2,511,748 RGD:6480464
G Atp5f1e ATP synthase F1 subunit epsilon JBrowse link 3 172,563,105 172,566,007 RGD:6480464
G Atp5mf ATP synthase membrane subunit f JBrowse link 12 11,191,799 11,198,369 RGD:6480464
G Atp5pd ATP synthase peripheral stalk subunit d JBrowse link 10 103,967,340 103,972,552 RGD:6480464
G Atp5pf ATP synthase peripheral stalk subunit F6 JBrowse link 11 24,286,806 24,294,419 RGD:6480464
G Atp5po ATP synthase peripheral stalk subunit OSCP JBrowse link 11 32,081,606 32,087,918 RGD:6480464
G Atrx ATRX, chromatin remodeler JBrowse link X 76,820,110 76,979,155 RGD:6480464
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bcl2l10 BCL2 like 10 JBrowse link 8 82,288,705 82,294,750 RGD:6480464
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:6480464
G Bdh1 3-hydroxybutyrate dehydrogenase 1 JBrowse link 11 72,577,547 72,619,435 RGD:6480464
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:6480464
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:6480464
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:6480464
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:6480464
G Bphl biphenyl hydrolase like JBrowse link 17 31,498,877 31,535,172 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:6480464
G Casp14 caspase 14 JBrowse link 7 13,938,376 13,944,286 RGD:6480464
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:6480464
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Coq4 coenzyme Q4 JBrowse link 3 8,349,386 8,357,719 RGD:6480464
G Coq5 coenzyme Q5, methyltransferase JBrowse link 12 47,078,753 47,095,438 RGD:6480464
G Cox15 cytochrome c oxidase assembly homolog COX15 JBrowse link 1 263,494,850 263,511,510 RGD:6480464
G Cox17 cytochrome c oxidase copper chaperone COX17 JBrowse link 11 64,962,663 64,968,437 RGD:6480464
G Cox4i1 cytochrome c oxidase subunit 4i1 JBrowse link 19 54,245,958 54,252,198 RGD:6480464
G Cox6b1 cytochrome c oxidase subunit 6B1 JBrowse link 1 89,075,987 89,084,834 RGD:6480464
G Cox6c cytochrome c oxidase subunit 6C JBrowse link 7 74,723,177 74,735,650 RGD:6480464
G Cox7b cytochrome c oxidase subunit 7B JBrowse link X 77,065,427 77,071,676 RGD:6480464
G Cox7c cytochrome c oxidase subunit 7C JBrowse link 2 14,699,878 14,701,903 RGD:6480464
G Cox8a cytochrome c oxidase subunit 8A JBrowse link 1 222,466,575 222,468,896 RGD:6480464
G Cox8c cytochrome c oxidase subunit 8C JBrowse link 6 126,766,967 126,768,290 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1A JBrowse link 1 218,568,157 218,629,679 RGD:6480464
G Cpt1c carnitine palmitoyltransferase 1c JBrowse link 1 100,955,094 100,970,579 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Crat carnitine O-acetyltransferase JBrowse link 3 8,967,984 8,981,959 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 2 102,701,903 102,871,257 RGD:6480464
G Dapl1 death associated protein-like 1 JBrowse link 3 45,538,408 45,559,281 RGD:6480464
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:6480464
G Dbt dihydrolipoamide branched chain transacylase E2 JBrowse link 2 219,563,783 219,592,651 RGD:6480464
G Decr1 2,4-dienoyl-CoA reductase 1 JBrowse link 5 29,573,893 29,601,731 RGD:6480464
G Dffa DNA fragmentation factor subunit alpha JBrowse link 5 165,922,893 165,935,822 RGD:6480464
G Dlst dihydrolipoamide S-succinyltransferase JBrowse link 6 108,936,534 108,961,322 RGD:6480464
G Dmac2l distal membrane arm assembly complex 2 like JBrowse link 6 92,057,782 92,076,022 RGD:6480464
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 JBrowse link 2 120,503,093 120,531,782 RGD:6480464
G Ech1 enoyl-CoA hydratase 1 JBrowse link 1 87,009,798 87,015,996 RGD:6480464
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:6480464
G Faf1 Fas associated factor 1 JBrowse link 5 129,370,767 129,738,393 RGD:6480464
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:6480464
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gadd45g growth arrest and DNA-damage-inducible, gamma JBrowse link 17 13,391,474 13,393,219 RGD:6480464
G Gcdh glutaryl-CoA dehydrogenase JBrowse link 19 26,000,497 26,006,970 RGD:6480464
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial JBrowse link 1 275,843,823 275,906,880 RGD:6480464
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 4 71,621,777 71,626,096 RGD:6480464
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:6480464
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha JBrowse link 6 27,589,840 27,628,921 RGD:6480464
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase JBrowse link 5 154,294,841 154,308,582 RGD:6480464
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:6480464
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 JBrowse link 18 44,810,462 44,897,677 RGD:6480464
G Iars2 isoleucyl-tRNA synthetase 2, mitochondrial JBrowse link 13 103,229,868 103,265,019 RGD:6480464
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha JBrowse link 8 59,164,601 59,183,899 RGD:6480464
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta JBrowse link 3 122,808,564 122,813,638 RGD:6480464
G Immp2l inner mitochondrial membrane peptidase subunit 2 JBrowse link 6 60,958,351 61,859,457 RGD:6480464
G Ivd isovaleryl-CoA dehydrogenase JBrowse link 3 110,669,355 110,689,789 RGD:6480464
G Kif1b kinesin family member 1B JBrowse link 5 165,994,803 166,133,497 RGD:6480464
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:6480464
G Mccc2 methylcrotonoyl-CoA carboxylase 2 JBrowse link 2 30,175,017 30,246,028 RGD:6480464
G Mmut methylmalonyl-CoA mutase JBrowse link 9 23,323,934 23,352,144 RGD:6480464
G Mpc2 mitochondrial pyruvate carrier 2 JBrowse link 13 83,680,527 83,700,491 RGD:6480464
G Mrpl3 mitochondrial ribosomal protein L3 JBrowse link 8 113,603,533 113,626,893 RGD:6480464
G Mrpl50 mitochondrial ribosomal protein L50 JBrowse link 5 64,784,164 64,789,318 RGD:6480464
G Mt-atp8 mitochondrially encoded ATP synthase 8 JBrowse link MT 7,758 7,961 RGD:6480464
G Mt-nd2 mitochondrially encoded NADH dehydrogenase 2 JBrowse link MT 3,904 4,942 RGD:6480464
G Nadk2 NAD kinase 2, mitochondrial JBrowse link 2 58,462,588 58,504,735 RGD:6480464
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 JBrowse link 9 99,617,051 99,651,827 RGD:6480464
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 JBrowse link 18 29,585,671 29,587,760 RGD:6480464
G Ndufa4 NDUFA4, mitochondrial complex associated JBrowse link 4 38,233,680 38,240,848 RGD:6480464
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 JBrowse link 4 51,590,413 51,598,771 RGD:6480464
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 JBrowse link 3 15,362,888 15,379,386 RGD:6480464
G Ndufaf1 NADH:ubiquinone oxidoreductase complex assembly factor 1 JBrowse link 3 111,458,227 111,469,239 RGD:6480464
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 JBrowse link 4 67,378,188 67,385,267 RGD:6480464
G Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 JBrowse link 11 65,960,277 65,966,899 RGD:6480464
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 JBrowse link 19 24,701,067 24,705,405 RGD:6480464
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 1 264,298,671 264,303,712 RGD:6480464
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 13 89,606,848 89,623,506 RGD:6480464
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 JBrowse link 2 46,372,488 46,476,162 RGD:6480464
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 JBrowse link 2 26,471,173 26,471,587 RGD:6480464
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 7 12,318,776 12,326,403 RGD:6480464
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 JBrowse link 1 219,254,293 219,259,328 RGD:6480464
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 JBrowse link 9 113,875,718 113,900,169 RGD:6480464
G Ogdh oxoglutarate dehydrogenase JBrowse link 14 86,414,924 86,481,903 RGD:6480464
G Ogg1 8-oxoguanine DNA glycosylase JBrowse link 4 145,282,828 145,289,367 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pdcd1 programmed cell death 1 JBrowse link 9 101,305,742 101,319,937 RGD:6480464
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6480464
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:6480464
G Pdcd7 programmed cell death 7 JBrowse link 8 70,860,671 70,875,471 RGD:6480464
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:6480464
G Pecr peroxisomal trans-2-enoyl-CoA reductase JBrowse link 9 79,601,937 79,630,547 RGD:6480464
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K JBrowse link 4 88,694,395 88,721,374 RGD:6480464
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:6480464
G Pttg1 PTTG1 regulator of sister chromatid separation, securin JBrowse link 10 29,014,332 29,026,088 RGD:6480464
G Rad17 RAD17 checkpoint clamp loader component JBrowse link 2 30,634,353 30,664,618 RGD:6480464
G Rad51 RAD51 recombinase JBrowse link 3 110,918,240 110,942,920 RGD:6480464
G Rad9a RAD9 checkpoint clamp component A JBrowse link 1 219,443,347 219,450,574 RGD:6480464
G Ropn1 rhophilin associated tail protein 1 JBrowse link 11 69,326,785 69,355,788 RGD:6480464
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6480464
G Sdhc succinate dehydrogenase complex subunit C JBrowse link 13 89,498,047 89,518,979 RGD:6480464
G Sdhd succinate dehydrogenase complex subunit D JBrowse link 8 55,028,125 55,037,604 RGD:6480464
G Slc25a26 solute carrier family 25 member 26 JBrowse link 4 126,522,335 126,615,402 RGD:6480464
G Slc25a3 solute carrier family 25 member 3 JBrowse link 7 31,816,601 31,824,064 RGD:6480464
G Slc25a34 solute carrier family 25, member 34 JBrowse link 5 160,175,206 160,179,978 RGD:6480464
G Slc25a42 solute carrier family 25, member 42 JBrowse link 16 20,962,144 21,000,191 RGD:6480464
G Slc25a47 solute carrier family 25, member 47 JBrowse link 6 132,762,306 132,767,940 RGD:6480464
G Slc25a5 solute carrier family 25 member 5 JBrowse link X 123,404,570 123,407,637 RGD:6480464
G Spata19 spermatogenesis associated 19 JBrowse link 8 28,454,938 28,460,645 RGD:6480464
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:6480464
G Sucla2 succinate-CoA ligase ADP-forming beta subunit JBrowse link 15 55,461,695 55,516,954 RGD:6480464
G Terf1 telomeric repeat binding factor 1 JBrowse link 5 2,853,455 2,882,731 RGD:6480464
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:6480464
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:6480464
G Top2b DNA topoisomerase II beta JBrowse link 15 10,262,972 10,319,741 RGD:6480464
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:6480464
G Ucp3 uncoupling protein 3 JBrowse link 1 165,482,912 165,495,895 RGD:6480464
G Ung uracil-DNA glycosylase JBrowse link 12 48,246,593 48,255,547 RGD:6480464
G Uqcr10 ubiquinol-cytochrome c reductase, complex III subunit X JBrowse link 14 84,935,480 84,937,741 RGD:6480464
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI JBrowse link 7 12,171,146 12,175,838 RGD:6480464
G Uqcrb ubiquinol-cytochrome c reductase binding protein JBrowse link 7 71,264,501 71,269,869 RGD:6480464
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 JBrowse link 17 35,677,984 35,682,262 RGD:6480464
G Uqcrh ubiquinol-cytochrome c reductase hinge protein JBrowse link 5 134,919,040 134,927,235 RGD:6480464
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII JBrowse link 10 38,779,132 38,782,489 RGD:6480464
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:6480464
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:6480464
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:6480464
G Yars2 tyrosyl-tRNA synthetase 2 JBrowse link 11 88,882,615 88,888,377 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      biological role 19621
        immunomodulator 12647
          immunosuppressive agent 11916
            (+)-dexrazoxane 159
              dexrazoxane hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    main group molecular entity 19555
                      s-block molecular entity 19336
                        hydrogen molecular entity 19325
                          hydrides 18249
                            inorganic hydride 17113
                              pnictogen hydride 17071
                                nitrogen hydride 16891
                                  azane 16568
                                    ammonia 16565
                                      organic amino compound 16564
                                        tertiary amino compound 8523
                                          N-alkylpiperazine 2953
                                            razoxane 203
                                              (+)-dexrazoxane 159
                                                dexrazoxane hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.